GCF_902362415.1 - 9 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CABIWO010000001.1 (Paraclostridium bifermentans)

Region	Type	From	To
Region 1.1	cyclic-lactone-autoinducer	69,644	90,428
Region 1.2	terpene-precursor	145,611	166,498
Region 1.3	terpene	988,343	1,009,002
Region 1.4	cyclic-lactone-autoinducer	1,722,664	1,743,248
Region 1.5	RiPP-like	1,960,838	1,973,102

NZ_CABIWO010000002.1 (Paraclostridium bifermentans)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 2.1	ranthipeptide	153,966	175,626

NZ_CABIWO010000004.1 (Paraclostridium bifermentans)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 4.1	cyclic-lactone-autoinducer,ranthipeptide	29,987	60,209	Low	thurincin H	ribosomal:RiPP

NZ_CABIWO010000009.1 (Paraclostridium bifermentans)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 9.1	RRE-containing	1	14,307

NZ_CABIWO010000014.1 (Paraclostridium bifermentans)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 14.1	cyclic-lactone-autoinducer,lanthipeptide-class-i	880	28,568

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	cyclic-lactone-autoinducer	69,644	90,428
Region 1.2	terpene-precursor	145,611	166,498
Region 1.3	terpene	988,343	1,009,002
Region 1.4	cyclic-lactone-autoinducer	1,722,664	1,743,248
Region 1.5	RiPP-like	1,960,838	1,973,102
Region 2.1	ranthipeptide	153,966	175,626
Region 4.1	cyclic-lactone-autoinducer,ranthipeptide	29,987	60,209	Low	thurincin H	ribosomal:RiPP
Region 9.1	RRE-containing	1	14,307
Region 14.1	cyclic-lactone-autoinducer,lanthipeptide-class-i	880	28,568

No secondary metabolite regions were found in these records:: NZ_CABIWO010000003.1 (Paraclostridium bifermentans); NZ_CABIWO010000005.1 (Paraclostridium bifermentans); NZ_CABIWO010000006.1 (Paraclostridium bifermentans); NZ_CABIWO010000007.1 (Paraclostridium bifermentans); NZ_CABIWO010000008.1 (Paraclostridium bifermentans); NZ_CABIWO010000010.1 (Paraclostridium bifermentans); NZ_CABIWO010000011.1 (Paraclostridium bifermentans); NZ_CABIWO010000012.1 (Paraclostridium bifermentans); NZ_CABIWO010000013.1 (Paraclostridium bifermentans); NZ_CABIWO010000015.1 (Paraclostridium bifermentans); NZ_CABIWO010000016.1 (Paraclostridium bifermentans); NZ_CABIWO010000017.1 (Paraclostridium bifermentans); NZ_CABIWO010000018.1 (Paraclostridium bifermentans); NZ_CABIWO010000019.1 (Paraclostridium bifermentans); NZ_CABIWO010000020.1 (Paraclostridium bifermentans); NZ_CABIWO010000021.1 (Paraclostridium bifermentans); NZ_CABIWO010000022.1 (Paraclostridium bifermentans)

Compact view

NZ_CABIWO010000001.1 - Region 1 - cyclic-lactone-autoinducer

Download region GenBank file

Download region SVG

Location: 69,644 - 90,428 nt. (total: 20,785 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

FY209_RS00395: diguanylate cyclase

smcogs: SMCOG1025: diguanylate cyclase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000527.5	0.39	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000188.5	0.38	other (other)	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0000559.4	0.37	ribosomal	subtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000043.5	0.37	PKS	curacin A	Moorea producens 19L
BGC0001789.3	0.36	ribosomal	suicin 90-1330	Streptococcus suis
BGC0000537.3	0.36	ribosomal	nisin U	Streptococcus uberis
BGC0000515.4	0.36	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0000536.3	0.36	ribosomal	nisin Q	Lactococcus lactis
BGC0000535.4	0.35	ribosomal	nisin A	Lactococcus lactis subsp. lactis
BGC0000310.5	0.35	NRPS	bacitracin	Bacillus licheniformis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000527.5	0.39	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000188.5	0.38	other (other)	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0000559.4	0.37	ribosomal	subtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000043.5	0.37	PKS	curacin A	Moorea producens 19L
BGC0001789.3	0.36	ribosomal	suicin 90-1330	Streptococcus suis
BGC0000537.3	0.36	ribosomal	nisin U	Streptococcus uberis
BGC0000515.4	0.36	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0000536.3	0.36	ribosomal	nisin Q	Lactococcus lactis
BGC0000535.4	0.35	ribosomal	nisin A	Lactococcus lactis subsp. lactis
BGC0000310.5	0.35	NRPS	bacitracin	Bacillus licheniformis

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.61 out of 32.93

Confidence: medium

Additional weak hits (2):

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.61 out of 30.97

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.20 out of 27.04

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
LexA variant 3	Repressor of DNA damage response

NZ_CABIWO010000001.1 - Region 2 - terpene-precursor

Download region GenBank file

Download region SVG

Location: 145,611 - 166,498 nt. (total: 20,888 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: synthase synthetase

FY209_RS00810: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

FY209_RS00820: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.48	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.45	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002283.2	0.45	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.45	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000665.5	0.37	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0000043.5	0.37	PKS	curacin A	Moorea producens 19L
BGC0000630.3	0.36	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0001594.3	0.35	other (other)	fischerindole L	Fischerella muscicola UTEX 1829
BGC0000666.5	0.35	terpene	xiamycin A	Streptomyces sp. SCSIO 02999

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.48	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.45	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002283.2	0.45	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.45	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000665.5	0.37	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0000043.5	0.37	PKS	curacin A	Moorea producens 19L
BGC0000630.3	0.36	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0001594.3	0.35	other (other)	fischerindole L	Fischerella muscicola UTEX 1829
BGC0000666.5	0.35	terpene	xiamycin A	Streptomyces sp. SCSIO 02999

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

FY209_RS00810: PT_FPPS_like

Domain 1 (32 - 294): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (2):

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.69 out of 30.98

Confidence: weak

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 15.81 out of 18.46

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description

NZ_CABIWO010000001.1 - Region 3 - terpene

Download region GenBank file

Download region SVG

Location: 988,343 - 1,009,002 nt. (total: 20,660 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

FY209_RS04745: aldehyde oxidase and xanthine dehydrogenase

smcogs: SMCOG1293: aldehyde oxidase and xanthine dehydrogenase

FY209_RS04805: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: aminotransferase

FY209_RS04765: aminotransferase

smcogs: SMCOG1019: aminotransferase

FY209_RS04775: aminotransferase

smcogs: SMCOG1019: aminotransferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001928.2	0.42	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0001903.3	0.41	other (other)	neocarazostatin A	Streptomyces sp. MA37
BGC0000487.5	0.39	ribosomal	carnocyclin	Carnobacterium maltaromaticum
BGC0000916.5	0.39	other (other)	molybdenum cofactor	Staphylococcus carnosus
BGC0000671.3	0.39	terpene	momilactone B	Oryza sativa Japonica Group
BGC0002496.3	0.39	NRPS	serratiochelin A, serratiochelin C, serratiochelin B	Serratia plymuthica
BGC0000204.5	0.38	PKS	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200
BGC0000218.5	0.38	PKS	doxorubicin	Streptomyces peucetius
BGC0000433.5	0.37	NRPS	surfactin	Bacillus velezensis FZB42
BGC0001987.2	0.37	PKS	koreenceine A, koreenceine B, koreenceine C, koreenceine D	Pseudomonas koreensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001928.2	0.42	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0001903.3	0.41	other (other)	neocarazostatin A	Streptomyces sp. MA37
BGC0000487.5	0.39	ribosomal	carnocyclin	Carnobacterium maltaromaticum
BGC0000916.5	0.39	other (other)	molybdenum cofactor	Staphylococcus carnosus
BGC0000671.3	0.39	terpene	momilactone B	Oryza sativa Japonica Group
BGC0002496.3	0.39	NRPS	serratiochelin A, serratiochelin C, serratiochelin B	Serratia plymuthica
BGC0000204.5	0.38	PKS	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200
BGC0000218.5	0.38	PKS	doxorubicin	Streptomyces peucetius
BGC0000433.5	0.37	NRPS	surfactin	Bacillus velezensis FZB42
BGC0001987.2	0.37	PKS	koreenceine A, koreenceine B, koreenceine C, koreenceine D	Pseudomonas koreensis

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

No product predictions

Genes with terpene domains:

FY209_RS04770: TS_Pyr4

Domain 1 (6 - 182): Pyr4 type terpene synthase

Subtype: unknown

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.06 out of 19.26

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.76 out of 23.05

Confidence: medium

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.96 out of 29.25

Confidence: medium

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.87 out of 21.55

Confidence: medium

Additional weak hits (3):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.73 out of 30.25

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.97 out of 36.54

Confidence: weak

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 15.52 out of 18.46

Confidence: weak

Terpene

TFBS Finder

Glossary

No acronyms to display

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
ArcA	Repressor of carbon oxidation
CRP	Cyclic AMP receptor protein
SypG	Regulator of biofilm formation and host colonization
ToxT	Regulator of MSHA biosynthesis

NZ_CABIWO010000001.1 - Region 4 - cyclic-lactone-autoinducer

Download region GenBank file

Download region SVG

Location: 1,722,664 - 1,743,248 nt. (total: 20,585 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

FY209_RS08235: dihydropteridine reductase

smcogs: SMCOG1159: dihydropteridine reductase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001727.3	0.40	ribosomal	paenilan	Paenibacillus polymyxa E681
BGC0000527.5	0.40	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000547.5	0.39	ribosomal	salivaricin 9	Streptococcus salivarius
BGC0000506.4	0.37	ribosomal	entianin	Bacillus subtilis subsp. spizizenii
BGC0000559.4	0.37	ribosomal	subtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000515.4	0.36	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0000536.3	0.35	ribosomal	nisin Q	Lactococcus lactis
BGC0001789.3	0.35	ribosomal	suicin 90-1330	Streptococcus suis
BGC0000537.3	0.35	ribosomal	nisin U	Streptococcus uberis
BGC0000535.4	0.35	ribosomal	nisin A	Lactococcus lactis subsp. lactis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001727.3	0.40	ribosomal	paenilan	Paenibacillus polymyxa E681
BGC0000527.5	0.40	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000547.5	0.39	ribosomal	salivaricin 9	Streptococcus salivarius
BGC0000506.4	0.37	ribosomal	entianin	Bacillus subtilis subsp. spizizenii
BGC0000559.4	0.37	ribosomal	subtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000515.4	0.36	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0000536.3	0.35	ribosomal	nisin Q	Lactococcus lactis
BGC0001789.3	0.35	ribosomal	suicin 90-1330	Streptococcus suis
BGC0000537.3	0.35	ribosomal	nisin U	Streptococcus uberis
BGC0000535.4	0.35	ribosomal	nisin A	Lactococcus lactis subsp. lactis

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.66 out of 29.38

Confidence: medium

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.47 out of 21.55

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.55 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.84 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.28 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.84 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.80 out of 29.38

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.75 out of 28.19

Confidence: medium

Additional weak hits (9):

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.59 out of 22.40

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 15.77 out of 19.52

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.58 out of 19.52

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 27.74 out of 36.54

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.16 out of 27.55

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.00 out of 30.98

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 17.59 out of 23.43

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.58 out of 19.52

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 23.40 out of 36.53

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
FuR variant 1	Ferric Uptake Regulator
ZuR variant 1	Zinc-responsive repressor

NZ_CABIWO010000001.1 - Region 5 - RiPP-like

Download region GenBank file

Download region SVG

Location: 1,960,838 - 1,973,102 nt. (total: 12,265 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: deaminase

FY209_RS09340: ornithine cyclodeaminase

smcogs: SMCOG1158: ornithine cyclodeaminase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002674.2	0.46	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0000504.5	0.43	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000617.5	0.43	ribosomal	coagulin	Bacillus coagulans
BGC0002579.2	0.42	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0001210.5	0.40	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000517.4	0.39	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0000624.3	0.39	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0002577.2	0.39	ribosomal	lactococcin G	Lactococcus lactis
BGC0000521.3	0.38	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000619.3	0.38	ribosomal	gassericin T	Lactobacillus gasseri

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002674.2	0.46	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0000504.5	0.43	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000617.5	0.43	ribosomal	coagulin	Bacillus coagulans
BGC0002579.2	0.42	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0001210.5	0.40	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000517.4	0.39	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0000624.3	0.39	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0002577.2	0.39	ribosomal	lactococcin G	Lactococcus lactis
BGC0000521.3	0.38	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000619.3	0.38	ribosomal	gassericin T	Lactobacillus gasseri

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.78 out of 20.97

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.03 out of 20.97

Confidence: medium

Additional weak hits (2):

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 17.06 out of 30.11

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.71 out of 30.97

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A

NZ_CABIWO010000002.1 - Region 1 - ranthipeptide

Download region GenBank file

Download region SVG

Location: 153,966 - 175,626 nt. (total: 21,661 nt) Show pHMM detection rules used

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: hydrolase

FY209_RS11455: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002407.3	0.31	other (other), saccharide	angustmycin A, angustmycin C	Streptomyces angustmyceticus
BGC0001387.5	0.31	other (other)	nucleocidin	Streptomyces calvus
BGC0002713.2	0.30	NRPS	mevalagmapeptide A, mevalagmapeptide B, mevalagmapeptide C, mevalagmapeptide D	Photorhabdus laumondii subsp. laumondii
BGC0000689.3	0.27	saccharide	2-deoxystreptamine	Micromonospora echinospora
BGC0002621.2	0.27	other (other)	angustmycin A, angustmycin B, angustmycin C, aristeromycin, arabinofuranosyladenine	Streptomyces angustmyceticus
BGC0001822.4	0.27	NRPS	vioprolide A, vioprolide B, vioprolide C, vioprolide D	Cystobacter sp.
BGC0001591.4	0.27	other (other)	fatty acid enol ester, N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0002597.2	0.25	NRPS, PKS	Nocuolactylate A, Nocuolactylate B, Nocuolactylate C	Nodularia sp. LEGE 06071
BGC0000027.4	0.25	PKS	ankaflavin, monascin, rubropunctatine, monascorubrin	Monascus pilosus
BGC0001704.3	0.25	other (other)	nocuolin A	Nodularia sp. HBU26

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002407.3	0.31	other (other), saccharide	angustmycin A, angustmycin C	Streptomyces angustmyceticus
BGC0001387.5	0.31	other (other)	nucleocidin	Streptomyces calvus
BGC0002713.2	0.30	NRPS	mevalagmapeptide A, mevalagmapeptide B, mevalagmapeptide C, mevalagmapeptide D	Photorhabdus laumondii subsp. laumondii
BGC0000689.3	0.27	saccharide	2-deoxystreptamine	Micromonospora echinospora
BGC0002621.2	0.27	other (other)	angustmycin A, angustmycin B, angustmycin C, aristeromycin, arabinofuranosyladenine	Streptomyces angustmyceticus
BGC0001822.4	0.27	NRPS	vioprolide A, vioprolide B, vioprolide C, vioprolide D	Cystobacter sp.
BGC0001591.4	0.27	other (other)	fatty acid enol ester, N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0002597.2	0.25	NRPS, PKS	Nocuolactylate A, Nocuolactylate B, Nocuolactylate C	Nodularia sp. LEGE 06071
BGC0000027.4	0.25	PKS	ankaflavin, monascin, rubropunctatine, monascorubrin	Monascus pilosus
BGC0001704.3	0.25	other (other)	nocuolin A	Nodularia sp. HBU26

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.88 out of 28.14

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.10 out of 27.55

Confidence: medium

Additional weak hits (3):

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 21.71 out of 33.73

Confidence: weak

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 21.05 out of 27.18

Confidence: weak

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 19.55 out of 27.18

Confidence: weak

RREFinder

TFBS Finder

RRE predictions

: RRE type: Ranthipeptide_rSAM_RRE; Location: 1 - 99; Score: 96.9

TFBS definitions

Regulator	Description
GnfM	Regulator of nitrogen-fixation genes
PerR	Peroxide regulator

NZ_CABIWO010000004.1 - Region 1 - cyclic-lactone-autoinducer,ranthipeptide

Download region GenBank file

Download region SVG

Location: 29,987 - 60,209 nt. (total: 30,223 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: hydrolase

FY209_RS13360: amidohydrolase

smcogs: SMCOG1244: amidohydrolase

Isomerases: mutase

FY209_RS13280: phosphoglycerate mutase

smcogs: SMCOG1101: phosphoglycerate mutase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002667.2	0.36	ribosomal	estericin A	Clostridium estertheticum
BGC0000600.3	0.33	ribosomal	thurincin H	Bacillus thuringiensis
BGC0000599.5	0.32	ribosomal	thuricin CD α, thuricin CD β	Bacillus thuringiensis
BGC0002575.2	0.27	ribosomal	cochonodin I	Streptococcus suis
BGC0002700.2	0.26	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0000488.4	0.26	ribosomal	circularin A	Clostridium beijerinckii
BGC0000616.4	0.24	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0002111.3	0.24	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0000552.3	0.23	ribosomal	SmbA, SmbB	Streptococcus mutans
BGC0000497.3	0.23	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002667.2	0.51	ribosomal	estericin A	Clostridium estertheticum
BGC0002306.2	0.50	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000600.3	0.49	ribosomal	thurincin H	Bacillus thuringiensis
BGC0002116.3	0.49	ribosomal	darobactin A	Photorhabdus khanii HGB 1456
BGC0000599.5	0.46	ribosomal	thuricin CD α, thuricin CD β	Bacillus thuringiensis
BGC0000513.3	0.45	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000589.5	0.44	ribosomal	microcin M	Escherichia coli Nissle 1917
BGC0002575.2	0.43	ribosomal	cochonodin I	Streptococcus suis
BGC0000488.4	0.43	ribosomal	circularin A	Clostridium beijerinckii
BGC0002700.2	0.42	ribosomal	bacinapeptin	Bacillus nakamurai

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 14.33 out of 18.16

Confidence: medium

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.70 out of 29.25

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.27 out of 28.19

Confidence: medium

Additional weak hits (3):

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 14.56 out of 30.12

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.62 out of 32.93

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.58 out of 19.52

Confidence: weak

RREFinder

TFBS Finder

RRE predictions

: RRE type: Thurincin_rSAM_RRE; Location: 26 - 96; Score: 49.6; RRE type: Subtilosin_rSAM_RRE; Location: 36 - 97; Score: 30.8
: RRE type: Thurincin_rSAM_RRE; Location: 26 - 96; Score: 49.6; RRE type: Subtilosin_rSAM_RRE; Location: 36 - 97; Score: 30.8

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
SypG	Regulator of biofilm formation and host colonization
ZuR variant 1	Zinc-responsive repressor

NZ_CABIWO010000009.1 - Region 1 - RRE-containing

Download region GenBank file

Download region SVG

Location: 1 - 14,307 nt. (total: 14,307 nt) Show pHMM detection rules used

Region on contig edge.

RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000486.4	0.40	ribosomal	butyrivibriocin AR10	Butyrivibrio fibrisolvens
BGC0001684.3	0.37	other (other)	N-acyloxyacyl glutamine	Klebsiella variicola
BGC0002700.2	0.36	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0000489.3	0.34	ribosomal	enterocin AS-48	Enterococcus faecalis
BGC0002111.3	0.34	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0002447.3	0.31	ribosomal	cerecyclin	Bacillus cereus
BGC0001391.3	0.29	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000555.3	0.27	ribosomal	staphylococcin C55 α, staphylococcin C55 β	Staphylococcus aureus
BGC0002663.2	0.25	ribosomal	amyloliquecidin GF610	Bacillus amyloliquefaciens UMAF6639
BGC0002669.2	0.24	ribosomal	TVA-YJ-2	Streptomyces sp. NRRL S-87

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000486.4	0.40	ribosomal	butyrivibriocin AR10	Butyrivibrio fibrisolvens
BGC0001684.3	0.37	other (other)	N-acyloxyacyl glutamine	Klebsiella variicola
BGC0002700.2	0.36	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0000489.3	0.34	ribosomal	enterocin AS-48	Enterococcus faecalis
BGC0002111.3	0.34	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0002447.3	0.31	ribosomal	cerecyclin	Bacillus cereus
BGC0001391.3	0.29	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000555.3	0.27	ribosomal	staphylococcin C55 α, staphylococcin C55 β	Staphylococcus aureus
BGC0002663.2	0.25	ribosomal	amyloliquecidin GF610	Bacillus amyloliquefaciens UMAF6639
BGC0002669.2	0.24	ribosomal	TVA-YJ-2	Streptomyces sp. NRRL S-87

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 22.67 out of 26.33

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.36 out of 29.38

Confidence: medium

Additional weak hits (6):

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 17.32 out of 29.51

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 19.97 out of 25.88

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.43 out of 32.74

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 13.14 out of 30.12

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 18.24 out of 30.11

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 13.89 out of 30.12

Confidence: weak

RREFinder

TFBS Finder

RRE predictions

: RRE type: PqqD_RRE; Location: 40 - 98; Score: 40.9; RRE type: Stand_Alone_Lasso_RRE; Location: 30 - 99; Score: 37.7; RRE type: Thurincin_rSAM_RRE; Location: 39 - 94; Score: 36.3

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
FuR variant 1	Ferric Uptake Regulator

NZ_CABIWO010000014.1 - Region 1 - cyclic-lactone-autoinducer,lanthipeptide-class-i

Download region GenBank file

Download region SVG

Location: 880 - 28,568 nt. (total: 27,689 nt) Show pHMM detection rules used

Region on contig edge.

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)
lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase dehydratase

FY209_RS17160: Lantibiotic dehydratase domain protein

smcogs: SMCOG1155: Lantibiotic dehydratase domain protein

FY209_RS17170: Lanthionine synthetase C family protein

smcogs: SMCOG1140: Lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002576.2	0.87	ribosomal	mechercharmycin	Thermoactinomyces sp.
BGC0001289.5	0.51	ribosomal	penisin	Paenibacillus ehimensis
BGC0000515.4	0.46	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0000542.3	0.46	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000541.5	0.46	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0002323.2	0.41	ribosomal	nisin J	Staphylococcus capitis
BGC0000556.5	0.40	ribosomal	streptin	Streptococcus pyogenes
BGC0000506.4	0.39	ribosomal	entianin	Bacillus subtilis subsp. spizizenii
BGC0000560.5	0.38	ribosomal	subtilomycin	Bacillus subtilis
BGC0000559.4	0.37	ribosomal	subtilin	Bacillus subtilis subsp. spizizenii ATCC 6633

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002576.2	0.74	ribosomal	mechercharmycin	Thermoactinomyces sp.
BGC0001289.5	0.59	ribosomal	penisin	Paenibacillus ehimensis
BGC0000542.3	0.57	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000541.5	0.57	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000515.4	0.54	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0002323.2	0.54	ribosomal	nisin J	Staphylococcus capitis
BGC0000506.4	0.52	ribosomal	entianin	Bacillus subtilis subsp. spizizenii
BGC0000556.5	0.51	ribosomal	streptin	Streptococcus pyogenes
BGC0000560.5	0.51	ribosomal	subtilomycin	Bacillus subtilis
BGC0000559.4	0.51	ribosomal	subtilin	Bacillus subtilis subsp. spizizenii ATCC 6633

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for FY209_RS17160

FY209_RS17155

Leader:

MNKDFDLNLKMDKAPSNDGKQGI

Core:

TSVAYCTPGCVTGQLCGSSECGLTRNCTGSIACA

Core with dehydrations:

DhbDhaVAYCysDhbPGCysVDhbGQLCysGDhaDhaECysGLDhbRNCysDhbGDhaIACysA

antiSMASH-DB 4.0 matches for FY209_RS17155

100.0%

NZ_CABIWO010000014.1:

Lanthipeptides: FY209_RS17155_lanthipeptide

1

TSVAYCTPGCVTGQLCGSSECGLTRNCTGSIACA

34

TSVAYCTPGCVTGQLCGSSECGLTRNCTGSIACA

1

TSVAYCTPGCVTGQLCGSSECGLTRNCTGSIACA

34

74.3%

NZ_CP029639.1:

Lanthipeptides: DMB88_RS07755_lanthipeptide

1

TSVAYCTPGCVTGQLCGSSECGLTRNCTGSIACA

34

TSVAYCTPGC TG CGSSECGLTR CT + CA

2

TSVAYCTPGCNTGSTCGSSECGLTRQCTNTWLCA

35

74.3%

NZ_CP075910.1and 3 others:

NZ_CP075971.1 Lanthipeptides: KLF29_RS14850_lanthipeptideNZ_CP075982.1 Lanthipeptides: KLF51_RS14900_lanthipeptideNZ_CP075994.1 Lanthipeptides: KLF26_RS16110_lanthipeptide

Lanthipeptides: KLF45_RS14835_lanthipeptide

1

TSVAYCTPGCVTGQLCGSSECGLTRNCTGSIACA

34

TSVAYCTPGC+TG+LCGSSECGLTR+CT + C+

2

TSVAYCTPGCLTGELCGSSECGLTRSCTNTWLCS

35

with 88 more sequence matches

Only the first 10 are displayed here.

71.4%

NZ_QLLI01000019.1:

Lanthipeptides: DET54_RS28075_lanthipeptide

1

TSVAYCTPGCVTGQLCGSSECGLTRNCTGSIAC

33

TSVAYCTPGC TG CG+SECGLTRNCT + C

2

TSVAYCTPGCNTGSTCGTSECGLTRNCTNTWLC

34

65.7%

NZ_CP070896.1and 2 others:

NZ_CP070896.1 Lanthipeptides: JWH23_RS09310_lanthipeptideNZ_CP070896.1 Lanthipeptides: JWH23_RS09310_lanthipeptide

Lanthipeptides: JWH23_RS09310_lanthipeptide

2

SVAYCTPGCVTGQLCGSSECGLTRNCTGSIAC

33

SVAYCTPGC+TG CG+SECG+TRNCT + C

3

SVAYCTPGCLTGTTCGTSECGMTRNCTNTWLC

34

50.0%

NC_022237.1and 1 other:

NZ_JUZI01000019.1 Lanthipeptides: ADI02_RS09325_lanthipeptide

Lanthipeptides: SII_RS05025_lanthipeptide

1

TSVAYCTPGCVTGQLCGSSECGLTRNCTGSIA

32

TSV CTPGCVTG L G + T NC I+

2

TSVFMCTPGCVTGALMGCNLQTATCNCHVHIS

33

48.6%

NZ_CP073683.1and 1 other:

NZ_CP092779.1 Lanthipeptides: MJ749_RS08075_lanthipeptide

Lanthipeptides: KAI37_RS08180_lanthipeptide

1

TSVAYCTPGCVTGQLCGSSECG

22

TSV CTPGC+TG CGSSECG

2

TSVFACTPGCITGPNCGSSECG

23

47.1%

NZ_KE951497.1:

Lanthipeptides: allorf_8519_8683_lanthipeptide

1

TSVAYCTPGCVTGQL-CGSSECGLTRNCTGSIAC

33

TS CTPGC TG + C +++C T C+ S+AC

2

TSKFLCTPGCPTGGIACFTTQC--TNGCSISVAC

33

45.7%

NZ_CP013655.1and 2 others:

NZ_CP013655.1 Lanthipeptides: ATZ35_RS03635_lanthipeptideNZ_CP013655.1 Lanthipeptides: ATZ35_RS03630_lanthipeptide

Lanthipeptides: ATZ35_RS03640_lanthipeptide

1

TSVAYCTPGCVTGQLCGSSECGLTRNCTGSI

31

TS + CTPGCVTG L G + +T NC+ I

2

TSKSLCTPGCVTGVLMGCALKTITCNCSVGI

32

44.1%

NZ_CP085954.1:

Lanthipeptides: LK411_RS13585_lanthipeptide

1

TSVAYCTPGCVTGQL-CGSSECGLTRNCT

28

TS + CTPGC TG L C + C T CT

2

TSKSLCTPGCPTGALGCFTQNCDPTNGCT

30

42.9%

NZ_CP025696.1and 1 other:

NZ_LNZF01000001.1 Lanthipeptides: AVK83_RS25720_lanthipeptide

Lanthipeptides: C0638_RS24580_lanthipeptide

1

TSVAYCTPGCVTGQLCGSSECG

22

TS CT GC+TG CGSSECG

2

TSWFACTGGCLTGSNCGSSECG

23

42.9%

NZ_FNDP01000013.1and 1 other:

NZ_FNDP01000013.1 Lanthipeptides: BLP54_RS11225_lanthipeptide

Lanthipeptides: BLP54_RS11220_lanthipeptide

1

TSVAYCTPGCVTGQLCGSSECGLTRNCT

28

TS + CTPGCVTG L G + T NC+

4

TSKSLCTPGCVTGLLMGCAGSSATCNCS

31

42.9%

NZ_FNDP01000013.1:

Lanthipeptides: BLP54_RS11230_lanthipeptide

1

TSVAYCTPGCVTGQLCGSSECGLTRNCT

28

TS + CTPGCVTG L G + T NC+

4

TSKSLCTPGCVTGVLMGCNNKTATCNCS

31

MIBiG 4.0 matches for FY209_RS17155

32.4%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

1

TSVAYCTPGCVTGQLCG

17

TS++ CTPGC TG L G

2

TSISLCTPGCKTGALMG

18

11.8%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

21

CGLTRNC

27

C LT+ C

19

CTLTKEC

25

7.7%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

21

CGLTRNC

27

C L++ C

28

CTLSKEC

34

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.76 out of 23.05

Confidence: medium

Additional weak hits (5):

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 15.69 out of 19.52

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.13 out of 19.52

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 18.24 out of 30.11

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 18.24 out of 30.11

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 21.08 out of 30.11

Confidence: weak

Lanthipeptides

RREFinder

TFBS Finder

Core peptide predictions

FY209_RS17155 - Class I

Cleavage pHMM score: 1.20

RODEO score: 22

Monoisotopic mass: 3150.4 Da

Molecular weight: 3152.6 Da

Number of bridges: 6

Alternative weights: (assuming N unmodified Ser/Thr residues); 3170.6 Da N = 1; 3188.6 Da N = 2; 3206.6 Da N = 3

RRE predictions

: RRE type: Lanthipeptide_LanB_RRE; Location: 158 - 240; Score: 40.2
: RRE type: Lanthipeptide_LanB_RRE; Location: 158 - 240; Score: 40.2

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production