Select genomic region:
Overview
1.1
1.2
1.3
1.4
1.5
2.1
4.1
9.1
14.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CABIWO010000001.1 (Paraclostridium bifermentans)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | cyclic-lactone-autoinducer | 69,644 | 90,428 |
Region 1.2 | terpene-precursor | 145,611 | 166,498 |  |
Region 1.3 | terpene | 988,343 | 1,009,002 |
Region 1.4 | cyclic-lactone-autoinducer | 1,722,664 | 1,743,248 |
Region 1.5 | RiPP-like | 1,960,838 | 1,973,102 |

NZ_CABIWO010000002.1 (Paraclostridium bifermentans)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 2.1 | ranthipeptide | 153,966 | 175,626 |

NZ_CABIWO010000004.1 (Paraclostridium bifermentans)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 4.1 | cyclic-lactone-autoinducer,ranthipeptide | 29,987 | 60,209 | Low | thurincin H | ribosomal:RiPP

NZ_CABIWO010000009.1 (Paraclostridium bifermentans)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 9.1 | RRE-containing | 1 | 14,307 |

NZ_CABIWO010000014.1 (Paraclostridium bifermentans)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 14.1 | cyclic-lactone-autoinducer,lanthipeptide-class-i | 880 | 28,568 |

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | cyclic-lactone-autoinducer | 69,644 | 90,428 |
Region 1.2 | terpene-precursor | 145,611 | 166,498 |  |
Region 1.3 | terpene | 988,343 | 1,009,002 |
Region 1.4 | cyclic-lactone-autoinducer | 1,722,664 | 1,743,248 |
Region 1.5 | RiPP-like | 1,960,838 | 1,973,102 |
Region 2.1 | ranthipeptide | 153,966 | 175,626 |
Region 4.1 | cyclic-lactone-autoinducer,ranthipeptide | 29,987 | 60,209 | Low | thurincin H | ribosomal:RiPP
Region 9.1 | RRE-containing | 1 | 14,307 |
Region 14.1 | cyclic-lactone-autoinducer,lanthipeptide-class-i | 880 | 28,568 |

No secondary metabolite regions were found in these records:
  NZ_CABIWO010000003.1 (Paraclostridium bifermentans)
  NZ_CABIWO010000005.1 (Paraclostridium bifermentans)
  NZ_CABIWO010000006.1 (Paraclostridium bifermentans)
  NZ_CABIWO010000007.1 (Paraclostridium bifermentans)
  NZ_CABIWO010000008.1 (Paraclostridium bifermentans)
  NZ_CABIWO010000010.1 (Paraclostridium bifermentans)
  NZ_CABIWO010000011.1 (Paraclostridium bifermentans)
  NZ_CABIWO010000012.1 (Paraclostridium bifermentans)
  NZ_CABIWO010000013.1 (Paraclostridium bifermentans)
  NZ_CABIWO010000015.1 (Paraclostridium bifermentans)
  NZ_CABIWO010000016.1 (Paraclostridium bifermentans)
  NZ_CABIWO010000017.1 (Paraclostridium bifermentans)
  NZ_CABIWO010000018.1 (Paraclostridium bifermentans)
  NZ_CABIWO010000019.1 (Paraclostridium bifermentans)
  NZ_CABIWO010000020.1 (Paraclostridium bifermentans)
  NZ_CABIWO010000021.1 (Paraclostridium bifermentans)
  NZ_CABIWO010000022.1 (Paraclostridium bifermentans)

Compact view
NZ_CABIWO010000001.1 - Region 1 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 69,644 - 90,428 nt. (total: 20,785 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: cyclase
FY209_RS00395: diguanylate cyclase

smcogs
  SMCOG1025: diguanylate cyclase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000527.5 |  | 0.39 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0000188.5 |  | 0.38 | other (other) | saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2 | Cylindrospermopsis raciborskii T3
BGC0000559.4 |  | 0.37 | ribosomal | subtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000043.5 |  | 0.37 | PKS | curacin A | Moorea producens 19L
BGC0001789.3 |  | 0.36 | ribosomal | suicin 90-1330 | Streptococcus suis
BGC0000537.3 |  | 0.36 | ribosomal | nisin U | Streptococcus uberis
BGC0000515.4 |  | 0.36 | ribosomal | geobacillin I | Geobacillus thermodenitrificans NG80-2
BGC0000536.3 |  | 0.36 | ribosomal | nisin Q | Lactococcus lactis
BGC0000535.4 |  | 0.35 | ribosomal | nisin A | Lactococcus lactis subsp. lactis
BGC0000310.5 |  | 0.35 | NRPS | bacitracin | Bacillus licheniformis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000527.5 |  | 0.39 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0000188.5 |  | 0.38 | other (other) | saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2 | Cylindrospermopsis raciborskii T3
BGC0000559.4 |  | 0.37 | ribosomal | subtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000043.5 |  | 0.37 | PKS | curacin A | Moorea producens 19L
BGC0001789.3 |  | 0.36 | ribosomal | suicin 90-1330 | Streptococcus suis
BGC0000537.3 |  | 0.36 | ribosomal | nisin U | Streptococcus uberis
BGC0000515.4 |  | 0.36 | ribosomal | geobacillin I | Geobacillus thermodenitrificans NG80-2
BGC0000536.3 |  | 0.36 | ribosomal | nisin Q | Lactococcus lactis
BGC0000535.4 |  | 0.35 | ribosomal | nisin A | Lactococcus lactis subsp. lactis
BGC0000310.5 |  | 0.35 | NRPS | bacitracin | Bacillus licheniformis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.61 out of 32.93
Confidence: medium
Additional weak hits (2):
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.61 out of 30.97
Confidence: weak
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.20 out of 27.04
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
LexA variant 3 | Repressor of DNA damage response

NZ_CABIWO010000001.1 - Region 2 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 145,611 - 166,498 nt. (total: 20,888 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Ligases: synthase synthetase
FY209_RS00810: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

FY209_RS00820: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.48 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.45 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002283.2 |  | 0.45 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.45 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0000665.5 |  | 0.37 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0000043.5 |  | 0.37 | PKS | curacin A | Moorea producens 19L
BGC0000630.3 |  | 0.36 | terpene | (2R,3S,3'S)-2-hydroxyastaxanthin | Paracoccus haeundaensis
BGC0001594.3 |  | 0.35 | other (other) | fischerindole L | Fischerella muscicola UTEX 1829
BGC0000666.5 |  | 0.35 | terpene | xiamycin A | Streptomyces sp. SCSIO 02999

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.48 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.45 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002283.2 |  | 0.45 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.45 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0000665.5 |  | 0.37 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0000043.5 |  | 0.37 | PKS | curacin A | Moorea producens 19L
BGC0000630.3 |  | 0.36 | terpene | (2R,3S,3'S)-2-hydroxyastaxanthin | Paracoccus haeundaensis
BGC0001594.3 |  | 0.35 | other (other) | fischerindole L | Fischerella muscicola UTEX 1829
BGC0000666.5 |  | 0.35 | terpene | xiamycin A | Streptomyces sp. SCSIO 02999

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
FY209_RS00810: PT_FPPS_like
Domain 1 (32 - 294): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  DMAPP, IPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
No hits above weak threshold.
Weak hits (2):
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.69 out of 30.98
Confidence: weak
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 15.81 out of 18.46
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---

NZ_CABIWO010000001.1 - Region 3 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 988,343 - 1,009,002 nt. (total: 20,660 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
FY209_RS04745: aldehyde oxidase and xanthine dehydrogenase

smcogs
  SMCOG1293: aldehyde oxidase and xanthine dehydrogenase

FY209_RS04805: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: aminotransferase
FY209_RS04765: aminotransferase

smcogs
  SMCOG1019: aminotransferase

FY209_RS04775: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001928.2 |  | 0.42 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0001903.3 |  | 0.41 | other (other) | neocarazostatin A | Streptomyces sp. MA37
BGC0000487.5 |  | 0.39 | ribosomal | carnocyclin | Carnobacterium maltaromaticum
BGC0000916.5 |  | 0.39 | other (other) | molybdenum cofactor | Staphylococcus carnosus
BGC0000671.3 |  | 0.39 | terpene | momilactone B | Oryza sativa Japonica Group
BGC0002496.3 |  | 0.39 | NRPS | serratiochelin A, serratiochelin C, serratiochelin B | Serratia plymuthica
BGC0000204.5 |  | 0.38 | PKS | benastatin A, benastatin B, BE-43767, TAN1532B | Streptomyces sp. A2991200
BGC0000218.5 |  | 0.38 | PKS | doxorubicin | Streptomyces peucetius
BGC0000433.5 |  | 0.37 | NRPS | surfactin | Bacillus velezensis FZB42
BGC0001987.2 |  | 0.37 | PKS | koreenceine A, koreenceine B, koreenceine C, koreenceine D | Pseudomonas koreensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001928.2 |  | 0.42 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0001903.3 |  | 0.41 | other (other) | neocarazostatin A | Streptomyces sp. MA37
BGC0000487.5 |  | 0.39 | ribosomal | carnocyclin | Carnobacterium maltaromaticum
BGC0000916.5 |  | 0.39 | other (other) | molybdenum cofactor | Staphylococcus carnosus
BGC0000671.3 |  | 0.39 | terpene | momilactone B | Oryza sativa Japonica Group
BGC0002496.3 |  | 0.39 | NRPS | serratiochelin A, serratiochelin C, serratiochelin B | Serratia plymuthica
BGC0000204.5 |  | 0.38 | PKS | benastatin A, benastatin B, BE-43767, TAN1532B | Streptomyces sp. A2991200
BGC0000218.5 |  | 0.38 | PKS | doxorubicin | Streptomyces peucetius
BGC0000433.5 |  | 0.37 | NRPS | surfactin | Bacillus velezensis FZB42
BGC0001987.2 |  | 0.37 | PKS | koreenceine A, koreenceine B, koreenceine C, koreenceine D | Pseudomonas koreensis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:
No product predictions
Genes with terpene domains:
FY209_RS04770: TS_Pyr4
Domain 1 (6 - 182): Pyr4 type terpene synthase
Subtype: unknown
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.06 out of 19.26
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.76 out of 23.05
Confidence: medium
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.96 out of 29.25
Confidence: medium
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.87 out of 21.55
Confidence: medium
Additional weak hits (3):
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.73 out of 30.25
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.97 out of 36.54
Confidence: weak
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 15.52 out of 18.46
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.
No acronyms to display
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsR | Pleiotropic regulatory for antibiotic production
ArcA | Repressor of carbon oxidation
CRP | Cyclic AMP receptor protein
SypG | Regulator of biofilm formation and host colonization
ToxT | Regulator of MSHA biosynthesis

NZ_CABIWO010000001.1 - Region 4 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,722,664 - 1,743,248 nt. (total: 20,585 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
FY209_RS08235: dihydropteridine reductase

smcogs
  SMCOG1159: dihydropteridine reductase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001727.3 |  | 0.40 | ribosomal | paenilan | Paenibacillus polymyxa E681
BGC0000527.5 |  | 0.40 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0000547.5 |  | 0.39 | ribosomal | salivaricin 9 | Streptococcus salivarius
BGC0000506.4 |  | 0.37 | ribosomal | entianin | Bacillus subtilis subsp. spizizenii
BGC0000559.4 |  | 0.37 | ribosomal | subtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000515.4 |  | 0.36 | ribosomal | geobacillin I | Geobacillus thermodenitrificans NG80-2
BGC0000536.3 |  | 0.35 | ribosomal | nisin Q | Lactococcus lactis
BGC0001789.3 |  | 0.35 | ribosomal | suicin 90-1330 | Streptococcus suis
BGC0000537.3 |  | 0.35 | ribosomal | nisin U | Streptococcus uberis
BGC0000535.4 |  | 0.35 | ribosomal | nisin A | Lactococcus lactis subsp. lactis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001727.3 |  | 0.40 | ribosomal | paenilan | Paenibacillus polymyxa E681
BGC0000527.5 |  | 0.40 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0000547.5 |  | 0.39 | ribosomal | salivaricin 9 | Streptococcus salivarius
BGC0000506.4 |  | 0.37 | ribosomal | entianin | Bacillus subtilis subsp. spizizenii
BGC0000559.4 |  | 0.37 | ribosomal | subtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000515.4 |  | 0.36 | ribosomal | geobacillin I | Geobacillus thermodenitrificans NG80-2
BGC0000536.3 |  | 0.35 | ribosomal | nisin Q | Lactococcus lactis
BGC0001789.3 |  | 0.35 | ribosomal | suicin 90-1330 | Streptococcus suis
BGC0000537.3 |  | 0.35 | ribosomal | nisin U | Streptococcus uberis
BGC0000535.4 |  | 0.35 | ribosomal | nisin A | Lactococcus lactis subsp. lactis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.66 out of 29.38
Confidence: medium
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.47 out of 21.55
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.55 out of 29.38
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.84 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.28 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.84 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.80 out of 29.38
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.75 out of 28.19
Confidence: medium
Additional weak hits (9):
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.59 out of 22.40
Confidence: weak
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 15.77 out of 19.52
Confidence: weak
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.58 out of 19.52
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 27.74 out of 36.54
Confidence: weak
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.16 out of 27.55
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.00 out of 30.98
Confidence: weak
BldD
Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 17.59 out of 23.43
Confidence: weak
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.58 out of 19.52
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 23.40 out of 36.53
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArcA | Repressor of carbon oxidation
FuR variant 1 | Ferric Uptake Regulator
ZuR variant 1 | Zinc-responsive repressor

NZ_CABIWO010000001.1 - Region 5 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,960,838 - 1,973,102 nt. (total: 12,265 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: deaminase
FY209_RS09340: ornithine cyclodeaminase

smcogs
  SMCOG1158: ornithine cyclodeaminase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002674.2 |  | 0.46 | ribosomal | enterocin F4-9 | Enterococcus faecalis
BGC0000504.5 |  | 0.43 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000617.5 |  | 0.43 | ribosomal | coagulin | Bacillus coagulans
BGC0002579.2 |  | 0.42 | ribosomal | carnobacteriocin XY | Carnobacterium maltaromaticum
BGC0001210.5 |  | 0.40 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000517.4 |  | 0.39 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000624.3 |  | 0.39 | ribosomal | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0002577.2 |  | 0.39 | ribosomal | lactococcin G | Lactococcus lactis
BGC0000521.3 |  | 0.38 | ribosomal | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0000619.3 |  | 0.38 | ribosomal | gassericin T | Lactobacillus gasseri

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002674.2 |  | 0.46 | ribosomal | enterocin F4-9 | Enterococcus faecalis
BGC0000504.5 |  | 0.43 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000617.5 |  | 0.43 | ribosomal | coagulin | Bacillus coagulans
BGC0002579.2 |  | 0.42 | ribosomal | carnobacteriocin XY | Carnobacterium maltaromaticum
BGC0001210.5 |  | 0.40 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000517.4 |  | 0.39 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000624.3 |  | 0.39 | ribosomal | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0002577.2 |  | 0.39 | ribosomal | lactococcin G | Lactococcus lactis
BGC0000521.3 |  | 0.38 | ribosomal | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0000619.3 |  | 0.38 | ribosomal | gassericin T | Lactobacillus gasseri

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.78 out of 20.97
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.03 out of 20.97
Confidence: medium
Additional weak hits (2):
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 17.06 out of 30.11
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.71 out of 30.97
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A

NZ_CABIWO010000002.1 - Region 1 - ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 153,966 - 175,626 nt. (total: 21,661 nt) Show pHMM detection rules used
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: hydrolase
FY209_RS11455: metallo-beta-lactamase family protein

smcogs
  SMCOG1170: metallo-beta-lactamase family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002407.3 |  | 0.31 | other (other), saccharide | angustmycin A, angustmycin C | Streptomyces angustmyceticus
BGC0001387.5 |  | 0.31 | other (other) | nucleocidin | Streptomyces calvus
BGC0002713.2 |  | 0.30 | NRPS | mevalagmapeptide A, mevalagmapeptide B, mevalagmapeptide C, mevalagmapeptide D | Photorhabdus laumondii subsp. laumondii
BGC0000689.3 |  | 0.27 | saccharide | 2-deoxystreptamine | Micromonospora echinospora
BGC0002621.2 |  | 0.27 | other (other) | angustmycin A, angustmycin B, angustmycin C, aristeromycin, arabinofuranosyladenine | Streptomyces angustmyceticus
BGC0001822.4 |  | 0.27 | NRPS | vioprolide A, vioprolide B, vioprolide C, vioprolide D | Cystobacter sp.
BGC0001591.4 |  | 0.27 | other (other) | fatty acid enol ester, N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0002597.2 |  | 0.25 | NRPS, PKS | Nocuolactylate A, Nocuolactylate B, Nocuolactylate C | Nodularia sp. LEGE 06071
BGC0000027.4 |  | 0.25 | PKS | ankaflavin, monascin, rubropunctatine, monascorubrin | Monascus pilosus
BGC0001704.3 |  | 0.25 | other (other) | nocuolin A | Nodularia sp. HBU26

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002407.3 |  | 0.31 | other (other), saccharide | angustmycin A, angustmycin C | Streptomyces angustmyceticus
BGC0001387.5 |  | 0.31 | other (other) | nucleocidin | Streptomyces calvus
BGC0002713.2 |  | 0.30 | NRPS | mevalagmapeptide A, mevalagmapeptide B, mevalagmapeptide C, mevalagmapeptide D | Photorhabdus laumondii subsp. laumondii
BGC0000689.3 |  | 0.27 | saccharide | 2-deoxystreptamine | Micromonospora echinospora
BGC0002621.2 |  | 0.27 | other (other) | angustmycin A, angustmycin B, angustmycin C, aristeromycin, arabinofuranosyladenine | Streptomyces angustmyceticus
BGC0001822.4 |  | 0.27 | NRPS | vioprolide A, vioprolide B, vioprolide C, vioprolide D | Cystobacter sp.
BGC0001591.4 |  | 0.27 | other (other) | fatty acid enol ester, N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0002597.2 |  | 0.25 | NRPS, PKS | Nocuolactylate A, Nocuolactylate B, Nocuolactylate C | Nodularia sp. LEGE 06071
BGC0000027.4 |  | 0.25 | PKS | ankaflavin, monascin, rubropunctatine, monascorubrin | Monascus pilosus
BGC0001704.3 |  | 0.25 | other (other) | nocuolin A | Nodularia sp. HBU26

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.88 out of 28.14
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.10 out of 27.55
Confidence: medium
Additional weak hits (3):
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 21.71 out of 33.73
Confidence: weak
NrdR
Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 21.05 out of 27.18
Confidence: weak
NrdR
Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 19.55 out of 27.18
Confidence: weak
RREFinder
TFBS Finder
RRE predictions
RREfinder results sidepanel.

ranthipeptide protocluster (153965...175626)
FY209_RS11420
  RRE type: Ranthipeptide_rSAM_RRE
  Location: 1 - 99
  Score: 96.9

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
GnfM | Regulator of nitrogen-fixation genes
PerR | Peroxide regulator

NZ_CABIWO010000004.1 - Region 1 - cyclic-lactone-autoinducer,ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 29,987 - 60,209 nt. (total: 30,223 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: hydrolase
FY209_RS13360: amidohydrolase

smcogs
  SMCOG1244: amidohydrolase

Isomerases: mutase
FY209_RS13280: phosphoglycerate mutase

smcogs
  SMCOG1101: phosphoglycerate mutase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0002667.2 |  |  | 0.36 | ribosomal | estericin A | Clostridium estertheticum
BGC0000600.3 |  |  | 0.33 | ribosomal | thurincin H | Bacillus thuringiensis
BGC0000599.5 |  |  | 0.32 | ribosomal | thuricin CD α, thuricin CD β | Bacillus thuringiensis
BGC0002575.2 |  |  | 0.27 | ribosomal | cochonodin I | Streptococcus suis
BGC0002700.2 |  |  | 0.26 | ribosomal | bacinapeptin | Bacillus nakamurai
BGC0000488.4 |  |  | 0.26 | ribosomal | circularin A | Clostridium beijerinckii
BGC0000616.4 |  |  | 0.24 | ribosomal | amylocyclicin | Bacillus velezensis FZB42
BGC0002111.3 |  |  | 0.24 | ribosomal | andalusicin A, andalusicin B | Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0000552.3 |  |  | 0.23 | ribosomal | SmbA, SmbB | Streptococcus mutans
BGC0000497.3 |  |  | 0.23 | ribosomal | BHT-Aα, BHT-Aβ | Streptococcus ratti

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002667.2 |  | 0.51 | ribosomal | estericin A | Clostridium estertheticum
BGC0002306.2 |  | 0.50 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000600.3 |  | 0.49 | ribosomal | thurincin H | Bacillus thuringiensis
BGC0002116.3 |  | 0.49 | ribosomal | darobactin A | Photorhabdus khanii HGB 1456
BGC0000599.5 |  | 0.46 | ribosomal | thuricin CD α, thuricin CD β | Bacillus thuringiensis
BGC0000513.3 |  | 0.45 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0000589.5 |  | 0.44 | ribosomal | microcin M | Escherichia coli Nissle 1917
BGC0002575.2 |  | 0.43 | ribosomal | cochonodin I | Streptococcus suis
BGC0000488.4 |  | 0.43 | ribosomal | circularin A | Clostridium beijerinckii
BGC0002700.2 |  | 0.42 | ribosomal | bacinapeptin | Bacillus nakamurai

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 14.33 out of 18.16
Confidence: medium
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.70 out of 29.25
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.27 out of 28.19
Confidence: medium
Additional weak hits (3):
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 14.56 out of 30.12
Confidence: weak
RicR
Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.62 out of 32.93
Confidence: weak
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.58 out of 19.52
Confidence: weak
RREFinder
TFBS Finder
RRE predictions
RREfinder results sidepanel.

cyclic-lactone-autoinducer protocluster (29986...50710)
FY209_RS13260
  RRE type: Thurincin_rSAM_RRE
  Location: 26 - 96
  Score: 49.6
  RRE type: Subtilosin_rSAM_RRE
  Location: 36 - 97
  Score: 30.8
ranthipeptide protocluster (31177...60209)
FY209_RS13260
  RRE type: Thurincin_rSAM_RRE
  Location: 26 - 96
  Score: 49.6
  RRE type: Subtilosin_rSAM_RRE
  Location: 36 - 97
  Score: 30.8

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
SypG | Regulator of biofilm formation and host colonization
ZuR variant 1 | Zinc-responsive repressor

NZ_CABIWO010000009.1 - Region 1 - RRE-containing
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 14,307 nt. (total: 14,307 nt) Show pHMM detection rules used
Region on contig edge.
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RRE-containing | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000486.4 |  | 0.40 | ribosomal | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0001684.3 |  | 0.37 | other (other) | N-acyloxyacyl glutamine | Klebsiella variicola
BGC0002700.2 |  | 0.36 | ribosomal | bacinapeptin | Bacillus nakamurai
BGC0000489.3 |  | 0.34 | ribosomal | enterocin AS-48 | Enterococcus faecalis
BGC0002111.3 |  | 0.34 | ribosomal | andalusicin A, andalusicin B | Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0002447.3 |  | 0.31 | ribosomal | cerecyclin | Bacillus cereus
BGC0001391.3 |  | 0.29 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni
BGC0000555.3 |  | 0.27 | ribosomal | staphylococcin C55 α, staphylococcin C55 β | Staphylococcus aureus
BGC0002663.2 |  | 0.25 | ribosomal | amyloliquecidin GF610 | Bacillus amyloliquefaciens UMAF6639
BGC0002669.2 |  | 0.24 | ribosomal | TVA-YJ-2 | Streptomyces sp. NRRL S-87

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000486.4 |  | 0.40 | ribosomal | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0001684.3 |  | 0.37 | other (other) | N-acyloxyacyl glutamine | Klebsiella variicola
BGC0002700.2 |  | 0.36 | ribosomal | bacinapeptin | Bacillus nakamurai
BGC0000489.3 |  | 0.34 | ribosomal | enterocin AS-48 | Enterococcus faecalis
BGC0002111.3 |  | 0.34 | ribosomal | andalusicin A, andalusicin B | Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0002447.3 |  | 0.31 | ribosomal | cerecyclin | Bacillus cereus
BGC0001391.3 |  | 0.29 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni
BGC0000555.3 |  | 0.27 | ribosomal | staphylococcin C55 α, staphylococcin C55 β | Staphylococcus aureus
BGC0002663.2 |  | 0.25 | ribosomal | amyloliquecidin GF610 | Bacillus amyloliquefaciens UMAF6639
BGC0002669.2 |  | 0.24 | ribosomal | TVA-YJ-2 | Streptomyces sp. NRRL S-87

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 22.67 out of 26.33
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.36 out of 29.38
Confidence: medium
Additional weak hits (6):
DosR
Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 17.32 out of 29.51
Confidence: weak
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 19.97 out of 25.88
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.43 out of 32.74
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 13.14 out of 30.12
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 18.24 out of 30.11
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 13.89 out of 30.12
Confidence: weak
RREFinder
TFBS Finder
RRE predictions
RREfinder results sidepanel.

RRE-containing protocluster (0...14307)
FY209_RS16035
  RRE type: PqqD_RRE
  Location: 40 - 98
  Score: 40.9
  RRE type: Stand_Alone_Lasso_RRE
  Location: 30 - 99
  Score: 37.7
  RRE type: Thurincin_rSAM_RRE
  Location: 39 - 94
  Score: 36.3

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
FuR variant 1 | Ferric Uptake Regulator

NZ_CABIWO010000014.1 - Region 1 - cyclic-lactone-autoinducer,lanthipeptide-class-i
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 880 - 28,568 nt. (total: 27,689 nt) Show pHMM detection rules used
Region on contig edge.
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)
lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: cyclase dehydratase
FY209_RS17160: Lantibiotic dehydratase domain protein

smcogs
  SMCOG1155: Lantibiotic dehydratase domain protein

FY209_RS17170: Lanthionine synthetase C family protein

smcogs
  SMCOG1140: Lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | lanthipeptide-class-i | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0002576.2 |  |  | 0.87 | ribosomal | mechercharmycin | Thermoactinomyces sp.
BGC0001289.5 |  |  | 0.51 | ribosomal | penisin | Paenibacillus ehimensis
BGC0000515.4 |  |  | 0.46 | ribosomal | geobacillin I | Geobacillus thermodenitrificans NG80-2
BGC0000542.3 |  |  | 0.46 | ribosomal | paenicidin B | Paenibacillus terrae
BGC0000541.5 |  |  | 0.46 | ribosomal | paenicidin A | Paenibacillus polymyxa
BGC0002323.2 |  |  | 0.41 | ribosomal | nisin J | Staphylococcus capitis
BGC0000556.5 |  |  | 0.40 | ribosomal | streptin | Streptococcus pyogenes
BGC0000506.4 |  |  | 0.39 | ribosomal | entianin | Bacillus subtilis subsp. spizizenii
BGC0000560.5 |  |  | 0.38 | ribosomal | subtilomycin | Bacillus subtilis
BGC0000559.4 |  |  | 0.37 | ribosomal | subtilin | Bacillus subtilis subsp. spizizenii ATCC 6633

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002576.2 |  | 0.74 | ribosomal | mechercharmycin | Thermoactinomyces sp.
BGC0001289.5 |  | 0.59 | ribosomal | penisin | Paenibacillus ehimensis
BGC0000542.3 |  | 0.57 | ribosomal | paenicidin B | Paenibacillus terrae
BGC0000541.5 |  | 0.57 | ribosomal | paenicidin A | Paenibacillus polymyxa
BGC0000515.4 |  | 0.54 | ribosomal | geobacillin I | Geobacillus thermodenitrificans NG80-2
BGC0002323.2 |  | 0.54 | ribosomal | nisin J | Staphylococcus capitis
BGC0000506.4 |  | 0.52 | ribosomal | entianin | Bacillus subtilis subsp. spizizenii
BGC0000556.5 |  | 0.51 | ribosomal | streptin | Streptococcus pyogenes
BGC0000560.5 |  | 0.51 | ribosomal | subtilomycin | Bacillus subtilis
BGC0000559.4 |  | 0.51 | ribosomal | subtilin | Bacillus subtilis subsp. spizizenii ATCC 6633

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for FY209_RS17160

FY209_RS17155
Leader:
MNKDFDLNLKMDKAPSNDGKQGI
Core:
T S V A Y C T P G C V T G Q L C G S S E C G L T R N C T G S I A C A
Core with dehydrations:
Dhb Dha V A Y Cys Dhb P G Cys V Dhb G Q L Cys G Dha Dha E Cys G L Dhb R N Cys Dhb G Dha I A Cys A

#### antiSMASH-DB 4.0 matches for FY209_RS17155

100.0%
NZ_CABIWO010000014.1:
Lanthipeptides: FY209_RS17155_lanthipeptide
1
T S V A Y C T P G C V T G Q L C G S S E C G L T R N C T G S I A C A
34
T S V A Y C T P G C V T G Q L C G S S E C G L T R N C T G S I A C A
1
T S V A Y C T P G C V T G Q L C G S S E C G L T R N C T G S I A C A
34
74.3%
NZ_CP029639.1:
Lanthipeptides: DMB88_RS07755_lanthipeptide
1
T S V A Y C T P G C V T G Q L C G S S E C G L T R N C T G S I A C A
34
T S V A Y C T P G C T G C G S S E C G L T R C T + C A
2
T S V A Y C T P G C N T G S T C G S S E C G L T R Q C T N T W L C A
35
74.3%
NZ_CP075910.1 and 3 others:
NZ_CP075971.1 Lanthipeptides: KLF29_RS14850_lanthipeptide NZ_CP075982.1 Lanthipeptides: KLF51_RS14900_lanthipeptide NZ_CP075994.1 Lanthipeptides: KLF26_RS16110_lanthipeptide
Lanthipeptides: KLF45_RS14835_lanthipeptide
1
T S V A Y C T P G C V T G Q L C G S S E C G L T R N C T G S I A C A
34
T S V A Y C T P G C+T G+L C G S S E C G L T R+C T + C+
2
T S V A Y C T P G C L T G E L C G S S E C G L T R S C T N T W L C S
35
with 88 more sequence matches
Only the first 10 are displayed here.
71.4%
NZ_QLLI01000019.1:
Lanthipeptides: DET54_RS28075_lanthipeptide
1
T S V A Y C T P G C V T G Q L C G S S E C G L T R N C T G S I A C
33
T S V A Y C T P G C T G C G+S E C G L T R N C T + C
2
T S V A Y C T P G C N T G S T C G T S E C G L T R N C T N T W L C
34
65.7%
NZ_CP070896.1 and 2 others:
NZ_CP070896.1 Lanthipeptides: JWH23_RS09310_lanthipeptide NZ_CP070896.1 Lanthipeptides: JWH23_RS09310_lanthipeptide
Lanthipeptides: JWH23_RS09310_lanthipeptide
2
S V A Y C T P G C V T G Q L C G S S E C G L T R N C T G S I A C
33
S V A Y C T P G C+T G C G+S E C G+T R N C T + C
3
S V A Y C T P G C L T G T T C G T S E C G M T R N C T N T W L C
34
50.0%
NC_022237.1 and 1 other:
NZ_JUZI01000019.1 Lanthipeptides: ADI02_RS09325_lanthipeptide
Lanthipeptides: SII_RS05025_lanthipeptide
1
T S V A Y C T P G C V T G Q L C G S S E C G L T R N C T G S I A
32
T S V C T P G C V T G L G + T N C I+
2
T S V F M C T P G C V T G A L M G C N L Q T A T C N C H V H I S
33
48.6%
NZ_CP073683.1 and 1 other:
NZ_CP092779.1 Lanthipeptides: MJ749_RS08075_lanthipeptide
Lanthipeptides: KAI37_RS08180_lanthipeptide
1
T S V A Y C T P G C V T G Q L C G S S E C G
22
T S V C T P G C+T G C G S S E C G
2
T S V F A C T P G C I T G P N C G S S E C G
23
47.1%
NZ_KE951497.1:
Lanthipeptides: allorf_8519_8683_lanthipeptide
1
T S V A Y C T P G C V T G Q L-C G S S E C G L T R N C T G S I A C
33
T S C T P G C T G + C +++C T C+ S+A C
2
T S K F L C T P G C P T G G I A C F T T Q C--T N G C S I S V A C
33
45.7%
NZ_CP013655.1 and 2 others:
NZ_CP013655.1 Lanthipeptides: ATZ35_RS03635_lanthipeptide NZ_CP013655.1 Lanthipeptides: ATZ35_RS03630_lanthipeptide
Lanthipeptides: ATZ35_RS03640_lanthipeptide
1
T S V A Y C T P G C V T G Q L C G S S E C G L T R N C T G S I
31
T S + C T P G C V T G L G + +T N C+ I
2
T S K S L C T P G C V T G V L M G C A L K T I T C N C S V G I
32
44.1%
NZ_CP085954.1:
Lanthipeptides: LK411_RS13585_lanthipeptide
1
T S V A Y C T P G C V T G Q L-C G S S E C G L T R N C T
28
T S + C T P G C T G L C + C T C T
2
T S K S L C T P G C P T G A L G C F T Q N C D P T N G C T
30
42.9%
NZ_CP025696.1 and 1 other:
NZ_LNZF01000001.1 Lanthipeptides: AVK83_RS25720_lanthipeptide
Lanthipeptides: C0638_RS24580_lanthipeptide
1
T S V A Y C T P G C V T G Q L C G S S E C G
22
T S C T G C+T G C G S S E C G
2
T S W F A C T G G C L T G S N C G S S E C G
23
42.9%
NZ_FNDP01000013.1 and 1 other:
NZ_FNDP01000013.1 Lanthipeptides: BLP54_RS11225_lanthipeptide
Lanthipeptides: BLP54_RS11220_lanthipeptide
1
T S V A Y C T P G C V T G Q L C G S S E C G L T R N C T
28
T S + C T P G C V T G L G + T N C+
4
T S K S L C T P G C V T G L L M G C A G S S A T C N C S
31
42.9%
NZ_FNDP01000013.1:
Lanthipeptides: BLP54_RS11230_lanthipeptide
1
T S V A Y C T P G C V T G Q L C G S S E C G L T R N C T
28
T S + C T P G C V T G L G + T N C+
4
T S K S L C T P G C V T G V L M G C N N K T A T C N C S
31

#### MIBiG 4.0 matches for FY209_RS17155

32.4%
BGC0000535.4 (ADJ56352.1):
Lanthipeptide: nisin A
1
T S V A Y C T P G C V T G Q L C G
17
T S++ C T P G C T G L G
2
T S I S L C T P G C K T G A L M G
18
11.8%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
21
C G L T R N C
27
C L T+ C
19
C T L T K E C
25
7.7%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
21
C G L T R N C
27
C L++ C
28
C T L S K E C
34

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.76 out of 23.05
Confidence: medium
Additional weak hits (5):
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 15.69 out of 19.52
Confidence: weak
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.13 out of 19.52
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 18.24 out of 30.11
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 18.24 out of 30.11
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 21.08 out of 30.11
Confidence: weak
Lanthipeptides
RREFinder
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

FY209_RS17155 - Class I
  Cleavage pHMM score: 1.20
  RODEO score: 22
  Monoisotopic mass: 3150.4 Da
  Molecular weight: 3152.6 Da
  Number of bridges: 6
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3170.6 Da N = 1
    3188.6 Da N = 2
    3206.6 Da N = 3

RRE predictions
RREfinder results sidepanel.

cyclic-lactone-autoinducer protocluster (879...21609)
FY209_RS17160
  RRE type: Lanthipeptide_LanB_RRE
  Location: 158 - 240
  Score: 40.2
lanthipeptide-class-i protocluster (2422...28568)
FY209_RS17160
  RRE type: Lanthipeptide_LanB_RRE
  Location: 158 - 240
  Score: 40.2

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsR | Pleiotropic regulatory for antibiotic production