GCF_900128955.1 - 4 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_FQTY01000024.1 (Tissierella praeacuta DSM 18095)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 14.1	ranthipeptide	4,773	26,197

NZ_FQTY01000001.1 (Tissierella praeacuta DSM 18095)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 21.1	terpene-precursor	228,114	248,974

NZ_FQTY01000005.1 (Tissierella praeacuta DSM 18095)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 28.1	cyclic-lactone-autoinducer	130,296	151,010

NZ_FQTY01000002.1 (Tissierella praeacuta DSM 18095)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 35.1	lanthipeptide-class-ii	406,491	429,721

Region	Type	From	To	Most similar known cluster
Region 14.1	ranthipeptide	4,773	26,197
Region 21.1	terpene-precursor	228,114	248,974
Region 28.1	cyclic-lactone-autoinducer	130,296	151,010
Region 35.1	lanthipeptide-class-ii	406,491	429,721

No secondary metabolite regions were found in these records:: NZ_FQTY01000043.1 (Tissierella praeacuta DSM 18095); NZ_FQTY01000042.1 (Tissierella praeacuta DSM 18095); NZ_FQTY01000041.1 (Tissierella praeacuta DSM 18095); NZ_FQTY01000039.1 (Tissierella praeacuta DSM 18095); NZ_FQTY01000037.1 (Tissierella praeacuta DSM 18095); NZ_FQTY01000038.1 (Tissierella praeacuta DSM 18095); NZ_FQTY01000036.1 (Tissierella praeacuta DSM 18095); NZ_FQTY01000032.1 (Tissierella praeacuta DSM 18095); NZ_FQTY01000033.1 (Tissierella praeacuta DSM 18095); NZ_FQTY01000031.1 (Tissierella praeacuta DSM 18095); NZ_FQTY01000030.1 (Tissierella praeacuta DSM 18095); NZ_FQTY01000029.1 (Tissierella praeacuta DSM 18095); NZ_FQTY01000027.1 (Tissierella praeacuta DSM 18095); NZ_FQTY01000023.1 (Tissierella praeacuta DSM 18095); NZ_FQTY01000009.1 (Tissierella praeacuta DSM 18095); NZ_FQTY01000035.1 (Tissierella praeacuta DSM 18095); NZ_FQTY01000018.1 (Tissierella praeacuta DSM 18095); NZ_FQTY01000011.1 (Tissierella praeacuta DSM 18095); NZ_FQTY01000017.1 (Tissierella praeacuta DSM 18095); NZ_FQTY01000026.1 (Tissierella praeacuta DSM 18095); NZ_FQTY01000007.1 (Tissierella praeacuta DSM 18095); NZ_FQTY01000019.1 (Tissierella praeacuta DSM 18095); NZ_FQTY01000006.1 (Tissierella praeacuta DSM 18095); NZ_FQTY01000040.1 (Tissierella praeacuta DSM 18095); NZ_FQTY01000034.1 (Tissierella praeacuta DSM 18095); NZ_FQTY01000025.1 (Tissierella praeacuta DSM 18095); NZ_FQTY01000008.1 (Tissierella praeacuta DSM 18095); NZ_FQTY01000004.1 (Tissierella praeacuta DSM 18095); NZ_FQTY01000010.1 (Tissierella praeacuta DSM 18095); NZ_FQTY01000003.1 (Tissierella praeacuta DSM 18095); NZ_FQTY01000021.1 (Tissierella praeacuta DSM 18095); NZ_FQTY01000012.1 (Tissierella praeacuta DSM 18095); NZ_FQTY01000014.1 (Tissierella praeacuta DSM 18095); NZ_FQTY01000013.1 (Tissierella praeacuta DSM 18095); NZ_FQTY01000015.1 (Tissierella praeacuta DSM 18095); NZ_FQTY01000028.1 (Tissierella praeacuta DSM 18095); NZ_FQTY01000020.1 (Tissierella praeacuta DSM 18095); NZ_FQTY01000022.1 (Tissierella praeacuta DSM 18095); NZ_FQTY01000016.1 (Tissierella praeacuta DSM 18095)

Compact view

NZ_FQTY01000024.1 - Region 1 - ranthipeptide

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Location: 4,773 - 26,197 nt. (total: 21,425 nt) Show pHMM detection rules used

Region on contig edge.

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: hydrolase

BUB33_RS14635: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002306.2	0.47	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000684.4	0.34	PKS	asperthecin	Aspergillus nidulans FGSC A4
BGC0001860.4	0.32	ribosomal	thiomuracin	Thermobispora bispora DSM 43833
BGC0000613.5	0.32	ribosomal	thiomuracin A	Nonomuraea sp. Bp3714-39
BGC0002257.2	0.32	PKS	rufoschweinitzin	Xylaria schweinitzii
BGC0001155.5	0.30	ribosomal	GE2270	Planobispora rosea
BGC0000604.4	0.30	ribosomal	GE2270A	Nonomuraea sp. WU8817
BGC0002713.2	0.30	NRPS	mevalagmapeptide A, mevalagmapeptide B, mevalagmapeptide C, mevalagmapeptide D	Photorhabdus laumondii subsp. laumondii
BGC0001591.4	0.29	other (other)	fatty acid enol ester, N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0000689.3	0.29	saccharide	2-deoxystreptamine	Micromonospora echinospora

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002306.2	0.47	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000684.4	0.34	PKS	asperthecin	Aspergillus nidulans FGSC A4
BGC0001860.4	0.32	ribosomal	thiomuracin	Thermobispora bispora DSM 43833
BGC0000613.5	0.32	ribosomal	thiomuracin A	Nonomuraea sp. Bp3714-39
BGC0002257.2	0.32	PKS	rufoschweinitzin	Xylaria schweinitzii
BGC0001155.5	0.30	ribosomal	GE2270	Planobispora rosea
BGC0000604.4	0.30	ribosomal	GE2270A	Nonomuraea sp. WU8817
BGC0002713.2	0.30	NRPS	mevalagmapeptide A, mevalagmapeptide B, mevalagmapeptide C, mevalagmapeptide D	Photorhabdus laumondii subsp. laumondii
BGC0001591.4	0.29	other (other)	fatty acid enol ester, N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0000689.3	0.29	saccharide	2-deoxystreptamine	Micromonospora echinospora

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 14.70 out of 18.16

Confidence: strong

Additional weak hits (1):

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 19.72 out of 32.38

Confidence: weak

RREFinder

TFBS Finder

RRE predictions

: RRE type: Ranthipeptide_rSAM_RRE; Location: 6 - 101; Score: 75.7

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator

NZ_FQTY01000001.1 - Region 1 - terpene-precursor

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Location: 228,114 - 248,974 nt. (total: 20,861 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: synthase synthetase

BUB33_RS01325: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

BUB33_RS01365: polyprenol-monophosphomannose synthase ppm1

smcogs: SMCOG1123: polyprenol-monophosphomannose synthase ppm1

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0001605.3	0.31	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0000678.5	0.31	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000528.5	0.31	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000665.5	0.31	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0000648.3	0.31	terpene	carotenoid	Myxococcus xanthus
BGC0000515.4	0.29	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0002346.3	0.29	ribosomal	kyamicin	Saccharopolyspora sp.

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0001605.3	0.31	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0000678.5	0.31	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000528.5	0.31	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000665.5	0.31	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0000648.3	0.31	terpene	carotenoid	Myxococcus xanthus
BGC0000515.4	0.29	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0002346.3	0.29	ribosomal	kyamicin	Saccharopolyspora sp.

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

BUB33_RS01325: PT_FPPS_like

Domain 1 (30 - 285): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: IPP, DMAPP → FPP

Transcription Factor Binding Sites

Binding sites found:

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 25.09 out of 28.19

Confidence: strong

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
ZuR variant 1	Zinc-responsive repressor

NZ_FQTY01000005.1 - Region 1 - cyclic-lactone-autoinducer

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Location: 130,296 - 151,010 nt. (total: 20,715 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

BUB33_RS07685: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002306.2	0.51	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000888.5	0.49	other (other)	bacilysin	Bacillus sp. CS93
BGC0001184.4	0.44	other (other)	bacilysin	Bacillus velezensis FZB42
BGC0002493.3	0.43	NRPS	parabactin	Paracoccus denitrificans PD1222
BGC0002404.2	0.42	other (other)	falcarindiol	Solanum lycopersicum
BGC0000571.3	0.42	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454
BGC0000600.3	0.41	ribosomal	thurincin H	Bacillus thuringiensis
BGC0000617.5	0.40	ribosomal	coagulin	Bacillus coagulans
BGC0001639.3	0.40	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0001638.4	0.40	ribosomal	klebsazolicin	Klebsiella pneumoniae subsp. ozaenae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002306.2	0.51	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000888.5	0.49	other (other)	bacilysin	Bacillus sp. CS93
BGC0001184.4	0.44	other (other)	bacilysin	Bacillus velezensis FZB42
BGC0002493.3	0.43	NRPS	parabactin	Paracoccus denitrificans PD1222
BGC0002404.2	0.42	other (other)	falcarindiol	Solanum lycopersicum
BGC0000571.3	0.42	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454
BGC0000600.3	0.41	ribosomal	thurincin H	Bacillus thuringiensis
BGC0000617.5	0.40	ribosomal	coagulin	Bacillus coagulans
BGC0001639.3	0.40	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0001638.4	0.40	ribosomal	klebsazolicin	Klebsiella pneumoniae subsp. ozaenae

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.54 out of 18.46

Confidence: medium

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 28.14 out of 28.14

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.38 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.94 out of 29.38

Confidence: medium

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 25.44 out of 28.14

Confidence: medium

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 25.44 out of 28.14

Confidence: medium

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 25.44 out of 28.14

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.76 out of 23.05

Confidence: medium

Additional weak hits (3):

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.62 out of 32.74

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.71 out of 26.85

Confidence: weak

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 20.67 out of 32.38

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
FuR variant 1	Ferric Uptake Regulator
PerR	Peroxide regulator
RpoN	Regulator of nitrogen assimilation and virulence
ToxT	Regulator of MSHA biosynthesis

NZ_FQTY01000002.1 - Region 1 - lanthipeptide-class-ii

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Location: 406,491 - 429,721 nt. (total: 23,231 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

BUB33_RS04610: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.53	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000539.5	0.51	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0001210.5	0.51	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000554.4	0.50	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000558.5	0.49	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0000500.5	0.47	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000528.5	0.47	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000626.3	0.46	ribosomal	thuricin	Bacillus thuringiensis
BGC0000521.3	0.45	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000525.5	0.45	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.53	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000539.5	0.51	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0001210.5	0.51	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000554.4	0.50	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000558.5	0.49	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0000500.5	0.47	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000528.5	0.47	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000626.3	0.46	ribosomal	thuricin	Bacillus thuringiensis
BGC0000521.3	0.45	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000525.5	0.45	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for BUB33_RS04610

BUB33_RS04605

Leader:

MSKKIENWKKSIYLKSENNDNPAGDIFRELSDNEIDGIMAGG

Core:

TANSYCHCYSNKDSCGHGCTITTECPVATVICC

Core with dehydrations:

DhbANDhaYCysHCysYDhaNKDDhaCysGHGCysDhbIDhbDhbECysPVADhbVICysCys

antiSMASH-DB 4.0 matches for BUB33_RS04605

100.0%

NZ_FQTY01000002.1:

Lanthipeptides: BUB33_RS04605_lanthipeptide

TANSYCHCYSNKDSCGHGCTITTECPVATVICC

85.3%

NZ_LR595858.1:

Lanthipeptides: FQT45_RS03330_lanthipeptide

TANSYCHCYSNKDSCGHGCTITTECPVATVICC

TANSYCHCYS KDSCG GCTITTECP+AT+ICC

TANSYCHCYSGKDSCGRGCTITTECPIATIICC

82.4%

NZ_GG666304.1:

Lanthipeptides: HMPREF0077_RS09155_lanthipeptide

TANSYCHCYSNKDSCGHGCTITTECPVATVICC

TAN++CHCYS KDSCGHGCTITTECP AT+ICC

TANTHCHCYSGKDSCGHGCTITTECPFATLICC

with 49 more sequence matches

Only the first 10 are displayed here.

79.4%

NZ_JADNMH010000005.1:

Lanthipeptides: I2E99_RS07105_lanthipeptide

TANSYCHCYSNKDSCGHGCTITTECPVATVICC

TAN+YCHCYS KDSCG CTITTECP+ATV+CC

TANTYCHCYSGKDSCGRRCTITTECPIATVVCC

73.5%

NZ_JADPCZ010000011.1and 1 other:

NZ_OW659477.1 Lanthipeptides: NMG62_RS06660_lanthipeptide

Lanthipeptides: I4W03_RS06785_lanthipeptide

TANSYCHCYSNKDSCGHGCTITTECPVATVICC

TAN+YCHCYS K SCG CT+TTECP+AT+ICC

TANTYCHCYSGKHSCGRACTVTTECPIATIICC

72.7%

NC_011900.1and 2 others:

NZ_NCVD01000002.1 Lanthipeptides: B7702_RS00350_lanthipeptideNZ_NCVL01000015.1 Lanthipeptides: B7694_RS04515_lanthipeptide

Lanthipeptides: SPN23F_RS06435_lanthipeptide

TANSYCHCYSNKDSCGHGCTITTECPVATVICC

TA SYC CYS + SCG GCTITTECP T ICC

TARSYCACYSGEHSCGRGCTITTECPFLTFICC

72.7%

NZ_CP102135.1:

Lanthipeptides: NQZ98_RS01500_lanthipeptide

TANSYCHCYSNKDSCGHGCTITTECPVATVICC

TA SYC CYS + SCG GCTITTECP T ICC

TARSYCGCYSGEHSCGRGCTITTECPFLTFICC

72.7%

NZ_JVCZ01000028.1:

Lanthipeptides: ADG88_RS11420_lanthipeptide

TANSYCHCYSNKDSCGHGCTITTECPVATVICC

TA SYC CYS ++SCG GCTITTECP T ICC

TARSYCACYSGENSCGRGCTITTECPFLTFICC

69.7%

NZ_CP040409.1and 4 others:

NZ_CP040411.1 Lanthipeptides: FE334_RS06825_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS09430_lanthipeptideNZ_JH601103.1 Lanthipeptides: HMPREF9703_RS02710_lanthipeptideNZ_NAQX01000046.1 Lanthipeptides: B8A46_RS06295_lanthipeptide

Lanthipeptides: FE336_RS08590_lanthipeptide

TANSYCHCYSNKDSCGHGCTITTECPVATVICC

TAN+YC CYS + SCG CTIT ECPV TV CC

TANTYCRCYSGRHSCGRACTITAECPVFTVACC

58.8%

NZ_JAESIP010000017.1and 3 others:

NZ_LT907978.1 Lanthipeptides: EHLA_RS12685_lanthipeptideNZ_QRYY01000029.1 Lanthipeptides: DWW21_RS18370_lanthipeptideNZ_SPFW01000044.1 Lanthipeptides: FGQ81_RS16590_lanthipeptide

Lanthipeptides: JMK14_RS12260_lanthipeptide

TANSYCHCYSNKDSCGHGCTITTECPVATVICC

TAN++C+CYS SCG CT T ECP+ T+ICC

TANTHCNCYSEDASCGRLCTGTAECPIMTIICC

47.1%

NZ_LMFO01000023.1:

Lanthipeptides: allorf_629531_629758_lanthipeptide

TANSYCHCYSNKDSCGHGCTITTECPVATVIC

+ N+Y CYS + SCG+ CT TTECP + C

SPNTYNSCYSKQKSCGNFCTFTTECPFLSFCC

36.4%

NZ_CP114875.1:

Lanthipeptides: O4Z47_RS14375_lanthipeptide

SNKDSCGHGCTITTECP-VATVICC

+ K+S G CT+T+EC +AT +CC

TKKNSSGDICTLTSECDHLATWVCC

33.3%

NZ_CP086242.1and 1 other:

NZ_CP086245.1 Lanthipeptides: LL037_RS25615_lanthipeptide

Lanthipeptides: LL038_RS25355_lanthipeptide

SCGHGCTITTECPVATVICC

S G CT TTEC + ICC

SSGAICTATTECTYFSAICC

MIBiG 4.0 matches for BUB33_RS04605

18.2%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

GHGCTITTEC

G CT+T EC

GAYCTLTVEC

18.2%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

GHGCTITTEC

G CT+T EC

GGWCTLTKEC

10.3%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

CTITTEC

CT++ EC

CTLSKEC

BUB33_RS16535

Leader:

MAAYCDDINGDNDTSTVVAGS

Core:

SGKEAEVKFLCCVLIANTPVNVKKLKFMRGEFSYERK

Core with dehydrations:

DhaGKEAEVKFLCysCysVLIANDhbPVNVKKLKFMRGEFDhaYERK

antiSMASH-DB 4.0 matches for BUB33_RS16535

100.0%

NZ_FQTY01000002.1:

Lanthipeptides: BUB33_RS16535_lanthipeptide

SGKEAEVKFLCCVLIANTPVNVKKLKFMRGEFSYERK

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.91 out of 26.06

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.30 out of 27.78

Confidence: strong

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 23.16 out of 26.33

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 14.70 out of 18.16

Confidence: strong

Additional weak hits (2):

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.54 out of 25.75

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.02 out of 30.22

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

BUB33_RS04605 - Class II

Cleavage pHMM score: -3.10

RODEO score: 0

Monoisotopic mass: 3339.4 Da

Molecular weight: 3341.8 Da

Number of bridges: 7

Alternative weights: (assuming N unmodified Ser/Thr residues); 3359.8 Da N = 1

BUB33_RS16535 - Class II

Cleavage pHMM score: -6.30

RODEO score: 0

Monoisotopic mass: 4207.3 Da

Molecular weight: 4210.0 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 4228.0 Da N = 1

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
AbrC3	Antibiotic production activator
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MogR	Repressor of flagellar motility genes