Select genomic region:
Overview
14.1
21.1
28.1
35.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_FQTY01000024.1 (Tissierella praeacuta DSM 18095)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 14.1 | ranthipeptide | 4,773 | 26,197 |

NZ_FQTY01000001.1 (Tissierella praeacuta DSM 18095)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 21.1 | terpene-precursor | 228,114 | 248,974 |

NZ_FQTY01000005.1 (Tissierella praeacuta DSM 18095)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 28.1 | cyclic-lactone-autoinducer | 130,296 | 151,010 |

NZ_FQTY01000002.1 (Tissierella praeacuta DSM 18095)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 35.1 | lanthipeptide-class-ii | 406,491 | 429,721 |

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 14.1 | ranthipeptide | 4,773 | 26,197 |
Region 21.1 | terpene-precursor | 228,114 | 248,974 |
Region 28.1 | cyclic-lactone-autoinducer | 130,296 | 151,010 |
Region 35.1 | lanthipeptide-class-ii | 406,491 | 429,721 |

No secondary metabolite regions were found in these records:
  NZ_FQTY01000043.1 (Tissierella praeacuta DSM 18095)
  NZ_FQTY01000042.1 (Tissierella praeacuta DSM 18095)
  NZ_FQTY01000041.1 (Tissierella praeacuta DSM 18095)
  NZ_FQTY01000039.1 (Tissierella praeacuta DSM 18095)
  NZ_FQTY01000037.1 (Tissierella praeacuta DSM 18095)
  NZ_FQTY01000038.1 (Tissierella praeacuta DSM 18095)
  NZ_FQTY01000036.1 (Tissierella praeacuta DSM 18095)
  NZ_FQTY01000032.1 (Tissierella praeacuta DSM 18095)
  NZ_FQTY01000033.1 (Tissierella praeacuta DSM 18095)
  NZ_FQTY01000031.1 (Tissierella praeacuta DSM 18095)
  NZ_FQTY01000030.1 (Tissierella praeacuta DSM 18095)
  NZ_FQTY01000029.1 (Tissierella praeacuta DSM 18095)
  NZ_FQTY01000027.1 (Tissierella praeacuta DSM 18095)
  NZ_FQTY01000023.1 (Tissierella praeacuta DSM 18095)
  NZ_FQTY01000009.1 (Tissierella praeacuta DSM 18095)
  NZ_FQTY01000035.1 (Tissierella praeacuta DSM 18095)
  NZ_FQTY01000018.1 (Tissierella praeacuta DSM 18095)
  NZ_FQTY01000011.1 (Tissierella praeacuta DSM 18095)
  NZ_FQTY01000017.1 (Tissierella praeacuta DSM 18095)
  NZ_FQTY01000026.1 (Tissierella praeacuta DSM 18095)
  NZ_FQTY01000007.1 (Tissierella praeacuta DSM 18095)
  NZ_FQTY01000019.1 (Tissierella praeacuta DSM 18095)
  NZ_FQTY01000006.1 (Tissierella praeacuta DSM 18095)
  NZ_FQTY01000040.1 (Tissierella praeacuta DSM 18095)
  NZ_FQTY01000034.1 (Tissierella praeacuta DSM 18095)
  NZ_FQTY01000025.1 (Tissierella praeacuta DSM 18095)
  NZ_FQTY01000008.1 (Tissierella praeacuta DSM 18095)
  NZ_FQTY01000004.1 (Tissierella praeacuta DSM 18095)
  NZ_FQTY01000010.1 (Tissierella praeacuta DSM 18095)
  NZ_FQTY01000003.1 (Tissierella praeacuta DSM 18095)
  NZ_FQTY01000021.1 (Tissierella praeacuta DSM 18095)
  NZ_FQTY01000012.1 (Tissierella praeacuta DSM 18095)
  NZ_FQTY01000014.1 (Tissierella praeacuta DSM 18095)
  NZ_FQTY01000013.1 (Tissierella praeacuta DSM 18095)
  NZ_FQTY01000015.1 (Tissierella praeacuta DSM 18095)
  NZ_FQTY01000028.1 (Tissierella praeacuta DSM 18095)
  NZ_FQTY01000020.1 (Tissierella praeacuta DSM 18095)
  NZ_FQTY01000022.1 (Tissierella praeacuta DSM 18095)
  NZ_FQTY01000016.1 (Tissierella praeacuta DSM 18095)

Compact view
NZ_FQTY01000024.1 - Region 1 - ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,773 - 26,197 nt. (total: 21,425 nt) Show pHMM detection rules used
Region on contig edge.
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: hydrolase
BUB33_RS14635: metallo-beta-lactamase family protein

smcogs
  SMCOG1170: metallo-beta-lactamase family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002306.2 |  | 0.47 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000684.4 |  | 0.34 | PKS | asperthecin | Aspergillus nidulans FGSC A4
BGC0001860.4 |  | 0.32 | ribosomal | thiomuracin | Thermobispora bispora DSM 43833
BGC0000613.5 |  | 0.32 | ribosomal | thiomuracin A | Nonomuraea sp. Bp3714-39
BGC0002257.2 |  | 0.32 | PKS | rufoschweinitzin | Xylaria schweinitzii
BGC0001155.5 |  | 0.30 | ribosomal | GE2270 | Planobispora rosea
BGC0000604.4 |  | 0.30 | ribosomal | GE2270A | Nonomuraea sp. WU8817
BGC0002713.2 |  | 0.30 | NRPS | mevalagmapeptide A, mevalagmapeptide B, mevalagmapeptide C, mevalagmapeptide D | Photorhabdus laumondii subsp. laumondii
BGC0001591.4 |  | 0.29 | other (other) | fatty acid enol ester, N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0000689.3 |  | 0.29 | saccharide | 2-deoxystreptamine | Micromonospora echinospora

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002306.2 |  | 0.47 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000684.4 |  | 0.34 | PKS | asperthecin | Aspergillus nidulans FGSC A4
BGC0001860.4 |  | 0.32 | ribosomal | thiomuracin | Thermobispora bispora DSM 43833
BGC0000613.5 |  | 0.32 | ribosomal | thiomuracin A | Nonomuraea sp. Bp3714-39
BGC0002257.2 |  | 0.32 | PKS | rufoschweinitzin | Xylaria schweinitzii
BGC0001155.5 |  | 0.30 | ribosomal | GE2270 | Planobispora rosea
BGC0000604.4 |  | 0.30 | ribosomal | GE2270A | Nonomuraea sp. WU8817
BGC0002713.2 |  | 0.30 | NRPS | mevalagmapeptide A, mevalagmapeptide B, mevalagmapeptide C, mevalagmapeptide D | Photorhabdus laumondii subsp. laumondii
BGC0001591.4 |  | 0.29 | other (other) | fatty acid enol ester, N-tetradecanoyl tyrosine | uncultured bacterium CSLC2
BGC0000689.3 |  | 0.29 | saccharide | 2-deoxystreptamine | Micromonospora echinospora

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 14.70 out of 18.16
Confidence: strong
Additional weak hits (1):
CsoR
Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 19.72 out of 32.38
Confidence: weak
RREFinder
TFBS Finder
RRE predictions
RREfinder results sidepanel.

ranthipeptide protocluster (4772...26197)
BUB33_RS14660
  RRE type: Ranthipeptide_rSAM_RRE
  Location: 6 - 101
  Score: 75.7

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator

NZ_FQTY01000001.1 - Region 1 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 228,114 - 248,974 nt. (total: 20,861 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Ligases: synthase synthetase
BUB33_RS01325: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

BUB33_RS01365: polyprenol-monophosphomannose synthase ppm1

smcogs
  SMCOG1123: polyprenol-monophosphomannose synthase ppm1

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0001605.3 |  | 0.31 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0000678.5 |  | 0.31 | terpene | pentalenolactone | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000528.5 |  | 0.31 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000665.5 |  | 0.31 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0000648.3 |  | 0.31 | terpene | carotenoid | Myxococcus xanthus
BGC0000515.4 |  | 0.29 | ribosomal | geobacillin I | Geobacillus thermodenitrificans NG80-2
BGC0002346.3 |  | 0.29 | ribosomal | kyamicin | Saccharopolyspora sp.

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0001605.3 |  | 0.31 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0000678.5 |  | 0.31 | terpene | pentalenolactone | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000528.5 |  | 0.31 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000665.5 |  | 0.31 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0000648.3 |  | 0.31 | terpene | carotenoid | Myxococcus xanthus
BGC0000515.4 |  | 0.29 | ribosomal | geobacillin I | Geobacillus thermodenitrificans NG80-2
BGC0002346.3 |  | 0.29 | ribosomal | kyamicin | Saccharopolyspora sp.

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
BUB33_RS01325: PT_FPPS_like
Domain 1 (30 - 285): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  IPP, DMAPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 25.09 out of 28.19
Confidence: strong
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ZuR variant 1 | Zinc-responsive repressor

NZ_FQTY01000005.1 - Region 1 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 130,296 - 151,010 nt. (total: 20,715 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
BUB33_RS07685: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002306.2 |  | 0.51 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000888.5 |  | 0.49 | other (other) | bacilysin | Bacillus sp. CS93
BGC0001184.4 |  | 0.44 | other (other) | bacilysin | Bacillus velezensis FZB42
BGC0002493.3 |  | 0.43 | NRPS | parabactin | Paracoccus denitrificans PD1222
BGC0002404.2 |  | 0.42 | other (other) | falcarindiol | Solanum lycopersicum
BGC0000571.3 |  | 0.42 | ribosomal | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0000600.3 |  | 0.41 | ribosomal | thurincin H | Bacillus thuringiensis
BGC0000617.5 |  | 0.40 | ribosomal | coagulin | Bacillus coagulans
BGC0001639.3 |  | 0.40 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0001638.4 |  | 0.40 | ribosomal | klebsazolicin | Klebsiella pneumoniae subsp. ozaenae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002306.2 |  | 0.51 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000888.5 |  | 0.49 | other (other) | bacilysin | Bacillus sp. CS93
BGC0001184.4 |  | 0.44 | other (other) | bacilysin | Bacillus velezensis FZB42
BGC0002493.3 |  | 0.43 | NRPS | parabactin | Paracoccus denitrificans PD1222
BGC0002404.2 |  | 0.42 | other (other) | falcarindiol | Solanum lycopersicum
BGC0000571.3 |  | 0.42 | ribosomal | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0000600.3 |  | 0.41 | ribosomal | thurincin H | Bacillus thuringiensis
BGC0000617.5 |  | 0.40 | ribosomal | coagulin | Bacillus coagulans
BGC0001639.3 |  | 0.40 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0001638.4 |  | 0.40 | ribosomal | klebsazolicin | Klebsiella pneumoniae subsp. ozaenae

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.54 out of 18.46
Confidence: medium
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 28.14 out of 28.14
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.38 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.94 out of 29.38
Confidence: medium
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 25.44 out of 28.14
Confidence: medium
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 25.44 out of 28.14
Confidence: medium
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 25.44 out of 28.14
Confidence: medium
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.76 out of 23.05
Confidence: medium
Additional weak hits (3):
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.62 out of 32.74
Confidence: weak
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.71 out of 26.85
Confidence: weak
CsoR
Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 20.67 out of 32.38
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsR | Pleiotropic regulatory for antibiotic production
FuR variant 1 | Ferric Uptake Regulator
PerR | Peroxide regulator
RpoN | Regulator of nitrogen assimilation and virulence
ToxT | Regulator of MSHA biosynthesis

NZ_FQTY01000002.1 - Region 1 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 406,491 - 429,721 nt. (total: 23,231 nt) Show pHMM detection rules used
Region on contig edge.
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
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Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: cyclase
BUB33_RS04610: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000504.5 |  | 0.53 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000539.5 |  | 0.51 | ribosomal | nukacin ISK-1 | Staphylococcus warneri
BGC0001210.5 |  | 0.51 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000554.4 |  | 0.50 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000558.5 |  | 0.49 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000500.5 |  | 0.47 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000528.5 |  | 0.47 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000626.3 |  | 0.46 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000521.3 |  | 0.45 | ribosomal | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0000525.5 |  | 0.45 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000504.5 |  | 0.53 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000539.5 |  | 0.51 | ribosomal | nukacin ISK-1 | Staphylococcus warneri
BGC0001210.5 |  | 0.51 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000554.4 |  | 0.50 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000558.5 |  | 0.49 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000500.5 |  | 0.47 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000528.5 |  | 0.47 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000626.3 |  | 0.46 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000521.3 |  | 0.45 | ribosomal | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0000525.5 |  | 0.45 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for BUB33_RS04610

BUB33_RS04605
Leader:
MSKKIENWKKSIYLKSENNDNPAGDIFRELSDNEIDGIMAGG
Core:
T A N S Y C H C Y S N K D S C G H G C T I T T E C P V A T V I C C
Core with dehydrations:
Dhb A N Dha Y Cys H Cys Y Dha N K D Dha Cys G H G Cys Dhb I Dhb Dhb E Cys P V A Dhb V I Cys Cys

#### antiSMASH-DB 4.0 matches for BUB33_RS04605

100.0%
NZ_FQTY01000002.1:
Lanthipeptides: BUB33_RS04605_lanthipeptide
1
T A N S Y C H C Y S N K D S C G H G C T I T T E C P V A T V I C C
33
T A N S Y C H C Y S N K D S C G H G C T I T T E C P V A T V I C C
1
T A N S Y C H C Y S N K D S C G H G C T I T T E C P V A T V I C C
33
85.3%
NZ_LR595858.1:
Lanthipeptides: FQT45_RS03330_lanthipeptide
1
T A N S Y C H C Y S N K D S C G H G C T I T T E C P V A T V I C C
33
T A N S Y C H C Y S K D S C G G C T I T T E C P+A T+I C C
2
T A N S Y C H C Y S G K D S C G R G C T I T T E C P I A T I I C C
34
82.4%
NZ_GG666304.1:
Lanthipeptides: HMPREF0077_RS09155_lanthipeptide
1
T A N S Y C H C Y S N K D S C G H G C T I T T E C P V A T V I C C
33
T A N++C H C Y S K D S C G H G C T I T T E C P A T+I C C
2
T A N T H C H C Y S G K D S C G H G C T I T T E C P F A T L I C C
34
with 49 more sequence matches
Only the first 10 are displayed here.
79.4%
NZ_JADNMH010000005.1:
Lanthipeptides: I2E99_RS07105_lanthipeptide
1
T A N S Y C H C Y S N K D S C G H G C T I T T E C P V A T V I C C
33
T A N+Y C H C Y S K D S C G C T I T T E C P+A T V+C C
2
T A N T Y C H C Y S G K D S C G R R C T I T T E C P I A T V V C C
34
73.5%
NZ_JADPCZ010000011.1 and 1 other:
NZ_OW659477.1 Lanthipeptides: NMG62_RS06660_lanthipeptide
Lanthipeptides: I4W03_RS06785_lanthipeptide
1
T A N S Y C H C Y S N K D S C G H G C T I T T E C P V A T V I C C
33
T A N+Y C H C Y S K S C G C T+T T E C P+A T+I C C
2
T A N T Y C H C Y S G K H S C G R A C T V T T E C P I A T I I C C
34
72.7%
NC_011900.1 and 2 others:
NZ_NCVD01000002.1 Lanthipeptides: B7702_RS00350_lanthipeptide NZ_NCVL01000015.1 Lanthipeptides: B7694_RS04515_lanthipeptide
Lanthipeptides: SPN23F_RS06435_lanthipeptide
1
T A N S Y C H C Y S N K D S C G H G C T I T T E C P V A T V I C C
33
T A S Y C C Y S + S C G G C T I T T E C P T I C C
1
T A R S Y C A C Y S G E H S C G R G C T I T T E C P F L T F I C C
33
72.7%
NZ_CP102135.1:
Lanthipeptides: NQZ98_RS01500_lanthipeptide
1
T A N S Y C H C Y S N K D S C G H G C T I T T E C P V A T V I C C
33
T A S Y C C Y S + S C G G C T I T T E C P T I C C
1
T A R S Y C G C Y S G E H S C G R G C T I T T E C P F L T F I C C
33
72.7%
NZ_JVCZ01000028.1:
Lanthipeptides: ADG88_RS11420_lanthipeptide
1
T A N S Y C H C Y S N K D S C G H G C T I T T E C P V A T V I C C
33
T A S Y C C Y S ++S C G G C T I T T E C P T I C C
1
T A R S Y C A C Y S G E N S C G R G C T I T T E C P F L T F I C C
33
69.7%
NZ_CP040409.1 and 4 others:
NZ_CP040411.1 Lanthipeptides: FE334_RS06825_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS09430_lanthipeptide NZ_JH601103.1 Lanthipeptides: HMPREF9703_RS02710_lanthipeptide NZ_NAQX01000046.1 Lanthipeptides: B8A46_RS06295_lanthipeptide
Lanthipeptides: FE336_RS08590_lanthipeptide
1
T A N S Y C H C Y S N K D S C G H G C T I T T E C P V A T V I C C
33
T A N+Y C C Y S + S C G C T I T E C P V T V C C
1
T A N T Y C R C Y S G R H S C G R A C T I T A E C P V F T V A C C
33
58.8%
NZ_JAESIP010000017.1 and 3 others:
NZ_LT907978.1 Lanthipeptides: EHLA_RS12685_lanthipeptide NZ_QRYY01000029.1 Lanthipeptides: DWW21_RS18370_lanthipeptide NZ_SPFW01000044.1 Lanthipeptides: FGQ81_RS16590_lanthipeptide
Lanthipeptides: JMK14_RS12260_lanthipeptide
1
T A N S Y C H C Y S N K D S C G H G C T I T T E C P V A T V I C C
33
T A N++C+C Y S S C G C T T E C P+ T+I C C
2
T A N T H C N C Y S E D A S C G R L C T G T A E C P I M T I I C C
34
47.1%
NZ_LMFO01000023.1:
Lanthipeptides: allorf_629531_629758_lanthipeptide
1
T A N S Y C H C Y S N K D S C G H G C T I T T E C P V A T V I C
32
+ N+Y C Y S + S C G+ C T T T E C P + C
3
S P N T Y N S C Y S K Q K S C G N F C T F T T E C P F L S F C C
34
36.4%
NZ_CP114875.1:
Lanthipeptides: O4Z47_RS14375_lanthipeptide
10
S N K D S C G H G C T I T T E C P-V A T V I C C
33
+ K+S G C T+T+E C +A T +C C
3
T K K N S S G D I C T L T S E C D H L A T W V C C
27
33.3%
NZ_CP086242.1 and 1 other:
NZ_CP086245.1 Lanthipeptides: LL037_RS25615_lanthipeptide
Lanthipeptides: LL038_RS25355_lanthipeptide
14
S C G H G C T I T T E C P V A T V I C C
33
S G C T T T E C + I C C
2
S S G A I C T A T T E C T Y F S A I C C
21

#### MIBiG 4.0 matches for BUB33_RS04605

18.2%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
16
G H G C T I T T E C
25
G C T+T E C
14
G A Y C T L T V E C
23
18.2%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
16
G H G C T I T T E C
25
G C T+T E C
16
G G W C T L T K E C
25
10.3%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
19
C T I T T E C
25
C T++ E C
28
C T L S K E C
34
BUB33_RS16535
Leader:
MAAYCDDINGDNDTSTVVAGS
Core:
S G K E A E V K F L C C V L I A N T P V N V K K L K F M R G E F S Y E R K
Core with dehydrations:
Dha G K E A E V K F L Cys Cys V L I A N Dhb P V N V K K L K F M R G E F Dha Y E R K

#### antiSMASH-DB 4.0 matches for BUB33_RS16535

100.0%
NZ_FQTY01000002.1:
Lanthipeptides: BUB33_RS16535_lanthipeptide
1
S G K E A E V K F L C C V L I A N T P V N V K K L K F M R G E F S Y E R K
37
S G K E A E V K F L C C V L I A N T P V N V K K L K F M R G E F S Y E R K
1
S G K E A E V K F L C C V L I A N T P V N V K K L K F M R G E F S Y E R K
37

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.91 out of 26.06
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.30 out of 27.78
Confidence: strong
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 23.16 out of 26.33
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 14.70 out of 18.16
Confidence: strong
Additional weak hits (2):
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.54 out of 25.75
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.02 out of 30.22
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

BUB33_RS04605 - Class II
  Cleavage pHMM score: -3.10
  RODEO score: 0
  Monoisotopic mass: 3339.4 Da
  Molecular weight: 3341.8 Da
  Number of bridges: 7
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3359.8 Da N = 1
BUB33_RS16535 - Class II
  Cleavage pHMM score: -6.30
  RODEO score: 0
  Monoisotopic mass: 4207.3 Da
  Molecular weight: 4210.0 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4228.0 Da N = 1

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
AbrC3 | Antibiotic production activator
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MogR | Repressor of flagellar motility genes