GCF_028532705.1 - 6 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP116962.1 (Enterococcus faecalis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	lanthipeptide-class-ii	324,027	347,011
Region 1.2	lassopeptide	995,063	1,019,444	Low	cochonodin I	ribosomal:RiPP
Region 1.3	cyclic-lactone-autoinducer	1,399,349	1,420,077
Region 1.4	RiPP-like	1,761,086	1,771,967
Region 1.5	terpene-precursor	2,242,162	2,263,043
Region 1.6	lanthipeptide-class-ii	2,700,575	2,723,556	High	cytolysin ClyLl/cytolysin ClyLs	ribosomal:RiPP:Lanthipeptide

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	lanthipeptide-class-ii	324,027	347,011
Region 1.2	lassopeptide	995,063	1,019,444	Low	cochonodin I	ribosomal:RiPP
Region 1.3	cyclic-lactone-autoinducer	1,399,349	1,420,077
Region 1.4	RiPP-like	1,761,086	1,771,967
Region 1.5	terpene-precursor	2,242,162	2,263,043
Region 1.6	lanthipeptide-class-ii	2,700,575	2,723,556	High	cytolysin ClyLl/cytolysin ClyLs	ribosomal:RiPP:Lanthipeptide

No secondary metabolite regions were found in these records:: NZ_CP116966.1 (Enterococcus faecalis); NZ_CP116963.1 (Enterococcus faecalis); NZ_CP116964.1 (Enterococcus faecalis); NZ_CP116965.1 (Enterococcus faecalis)

Compact view

NZ_CP116962.1 - Region 1 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 324,027 - 347,011 nt. (total: 22,985 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: deacetylase

PO880_RS01510: acetylornithine deacetylase

smcogs: SMCOG1247: acetylornithine deacetylase

Lyases: cyclase

PO880_RS01560: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.56	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000500.5	0.51	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000516.4	0.49	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000623.3	0.48	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000558.5	0.48	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0000521.3	0.48	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0002698.2	0.46	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000626.3	0.45	ribosomal	thuricin	Bacillus thuringiensis
BGC0001210.5	0.45	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0001407.5	0.44	ribosomal	bicereucin	Bacillus cereus SJ1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.56	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000500.5	0.51	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000516.4	0.49	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000623.3	0.48	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000558.5	0.48	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0000521.3	0.48	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0002698.2	0.46	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000626.3	0.45	ribosomal	thuricin	Bacillus thuringiensis
BGC0001210.5	0.45	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0001407.5	0.44	ribosomal	bicereucin	Bacillus cereus SJ1

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for PO880_RS01560

PO880_RS01550

Leader:

MEAEKIVGM

Core:

QFEDLSKEEMNFIAGGNNNARISPTIVTPVTPYTSYVASAAGSAALSAVSGLVSYTKKCF

Core with dehydrations:

QFEDLDhaKEEMNFIAGGNNNARIDhaPDhbIVDhbPVDhbPYDhbDhaYVADhaAAGDhaAALDhaAVDhaGLVDhaYDhbKKCysF

antiSMASH-DB 4.0 matches for PO880_RS01550

100.0%

NC_021023.1and 10 others:

NZ_CABGJL010000002.1 Lanthipeptides: FN048_RS03100_lanthipeptideNZ_CABGPX010000017.1 Lanthipeptides: FN189_RS10930_lanthipeptideNZ_CABGTR010000003.1 Lanthipeptides: FN307_RS09560_lanthipeptideNZ_CP097048.1 Lanthipeptides: M2906_RS12945_lanthipeptideNZ_CP116962.1 Lanthipeptides: PO880_RS01550_lanthipeptideNZ_GG670379.1 Lanthipeptides: EFDG_RS12820_lanthipeptideNZ_GL454198.1 Lanthipeptides: HMPREF9500_RS14730_lanthipeptideNZ_JTKS01000015.1 Lanthipeptides: QI17_RS10290_lanthipeptideNZ_KB944666.1 Lanthipeptides: WMS_RS03550_lanthipeptideNZ_KZ845971.1 Lanthipeptides: EB55_RS12320_lanthipeptide

Lanthipeptides: ENT_RS13925_lanthipeptide

1

QFEDLSKEEMNFIAGGNNNARISPTIVTPVTPYTSYVASAAGSAALSAVSGLVSYTKKCF

60

QFEDLSKEEMNFIAGGNNNARISPTIVTPVTPYTSYVASAAGSAALSAVSGLVSYTKKCF

1

QFEDLSKEEMNFIAGGNNNARISPTIVTPVTPYTSYVASAAGSAALSAVSGLVSYTKKCF

60

35.0%

NZ_GG730336.1:

Lanthipeptides: SAUG_RS08755_lanthipeptide

16

GNNNARISPTIVTPVTPYTSYVASAAGSAALSAVSGLVSYTKKCF

60

G + +PTI +P TPY ++ A +SAVSGLVSYTK C

2

GTVEPQATPTIASPFTPYAIEISIGA---TVSAVSGLVSYTKDCL

43

30.0%

NZ_FPCC01000026.1:

Lanthipeptides: BM377_RS12905_lanthipeptide

2

FEDLSKEEMNFIAG-GNNNARISPTIVTPVTPYTSYVASAAGSAALSAVS

50

FEDL+ E+M G G+ +A +P I+ P S A + ALS +S

2

FEDLNTEDMQNTQGAGDVDAETTPVIM----PICSPSAVVNPTLALSLIS

47

with 25 more sequence matches

Only the first 10 are displayed here.

28.3%

NZ_FPCC01000026.1:

Lanthipeptides: BM377_RS12900_lanthipeptide

2

FEDLSKEEM-NFIAGGNNNARISPTI--VTPVTPYTS

35

FEDL+ E+M N GG+ NA TI +T V P S

2

FEDLNTEDMQNTQGGGDVNAETIVTISNLTLVGPIVS

38

28.3%

NZ_JACSPZ010000014.1:

Lanthipeptides: H9635_RS18390_lanthipeptide

30

VTPYTSYVASAAGSA------ALSAVSGLVSYTKKCF

60

V P+T+ + SAA + A+SA+SGLVSY K C

4

VEPHTTPILSAATKSSKKCLGAISAISGLVSYNKDCL

40

27.4%

NZ_CP011152.1and 1 other:

NZ_CP011152.1 Lanthipeptides: WR47_RS28810_lanthipeptide

Lanthipeptides: WR47_RS28810_lanthipeptide

2

FEDLSKEEM-NFIAGGNNNARISPT-IVTPVTPYTSYVASAAGSAALSAVSGLVSYTKKC

59

E++ E+ N + G+ A S I+TP TP S G A + TK+C

6

LEEIQGNELLNAVGAGDVQANTSTVQILTPRTPIISNTLGNKGHAC--------TITKEC

57

26.7%

NC_021023.1and 9 others:

NZ_CABGJL010000002.1 Lanthipeptides: FN048_RS03095_lanthipeptideNZ_CABGPX010000017.1 Lanthipeptides: FN189_RS10935_lanthipeptideNZ_CABGTR010000003.1 Lanthipeptides: FN307_RS09565_lanthipeptideNZ_CP097048.1 Lanthipeptides: M2906_RS12940_lanthipeptideNZ_CP116962.1 Lanthipeptides: PO880_RS01555_lanthipeptideNZ_GG670379.1 Lanthipeptides: EFDG_RS12825_lanthipeptideNZ_GL454198.1 Lanthipeptides: HMPREF9500_RS14725_lanthipeptideNZ_KB944666.1 Lanthipeptides: WMS_RS03545_lanthipeptideNZ_KZ845971.1 Lanthipeptides: EB55_RS12315_lanthipeptide

Lanthipeptides: ENT_RS13920_lanthipeptide

17

NNNARISPTIVTPVTPYTSYVASAAGSAALSAVS

50

N+NARISPTI+ S +S GS LSA +

1

NDNARISPTIILSAATVASAASSFVGSYTLSAFT

34

26.7%

NZ_BMSZ01000006.1and 4 others:

NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12790_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS18195_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19730_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19730_lanthipeptide

Lanthipeptides: IE135_RS12790_lanthipeptide

20

ARISPTIVTPVTPYTSYVASAAGSAALSAVSGLVSYTKKC

59

A I+PTIV P T T+ + A SAA+ TK+C

6

AGITPTIV-PATAVTTVIVGA--SAAMQGGCPTSGCTKRC

42

26.7%

NZ_CP026035.1:

Lanthipeptides: C2H96_RS00305_lanthipeptide

31

TPYTSYVASAAG-------SAALSAVSGLVSYTKKCF

60

TP S V SA G S SA+SG+VS+ K C

8

TPAVSAVLSAVGRSTRLCISGIGSAISGIVSHNKDCL

44

26.7%

NZ_FPCC01000026.1:

Lanthipeptides: BM377_RS12915_lanthipeptide

2

FEDLSKEEMNFIAGGNNNARISPTIVTPVTPYTSYVASAAGSAALSAVSGLVSYTKKCF

60

+EDL+ E+M G + + T+ +T A S +SG +S KKC

2

YEDLNTEDMQNTQGAGDTE--AETVSLAIT-----------GAIASVISGAISL-KKCV

46

26.7%

NZ_KN125582.1:

Lanthipeptides: DJ91_RS27550_lanthipeptide

19

NARISPTIVTPVTPYTSYVASAAGSAALSAVSGLVSYTKKCF

60

+ R PT++ S ++SA ++ +SA+SGLVSY K C

4

DTRTHPTVIV-----VSRISSAKCASTISAISGLVSYNKDCL

40

25.0%

NZ_CP011152.1and 3 others:

NZ_CP011152.1 Lanthipeptides: WR47_RS28830_lanthipeptideNZ_CP011152.1 Lanthipeptides: WR47_RS28835_lanthipeptideNZ_CP011152.1 Lanthipeptides: WR47_RS28830_lanthipeptide

Lanthipeptides: WR47_RS28835_lanthipeptide

27

VTP-VTPYTSYVASAAGSAALSAVSGLVSYTKKC

59

VTP TP + +A+AAG A +SAV + + KC

3

VTPQATPTVTILATAAGGAVISAVLPTLKCSSKC

36

25.0%

NZ_CP094446.1:

Lanthipeptides: L3476_RS23825_lanthipeptide

25

TIVTPVTPYTSYVASAAGSAALSAVSGLVSYTKKCF

60

TIV+ VT + SA GSA +SG++S+ K C

11

TIVSAVTRSSKPCISAIGSA----ISGIISHNKDCL

42

MIBiG 4.0 matches for PO880_RS01550

11.7%

BGC0002130.3 (QKI29070.1):

Lanthipeptide: cacaoidin

29

PVTPYTSYVASAAGSAAL

46

P T Y S AS + +A+

4

PCTIYASVSASISATASW

21

6.7%

BGC0000582.4 (ADR72962.1):

Linaridin: cypemycin

28

TPVTP

32

TP TP

2

TPATP

6

PO880_RS01555

Leader:

MDEKQLDSLVGQKFEDLSKEEMNFIAGG

Core:

NDNARISPTIILSAATVASAASSFVGSYTLSAFTKCR

Core with dehydrations:

NDNARIDhaPDhbIILDhaAADhbVADhaAADhaDhaFVGDhaYDhbLDhaAFDhbKCysR

antiSMASH-DB 4.0 matches for PO880_RS01555

100.0%

NC_021023.1and 9 others:

NZ_CABGJL010000002.1 Lanthipeptides: FN048_RS03095_lanthipeptideNZ_CABGPX010000017.1 Lanthipeptides: FN189_RS10935_lanthipeptideNZ_CABGTR010000003.1 Lanthipeptides: FN307_RS09565_lanthipeptideNZ_CP097048.1 Lanthipeptides: M2906_RS12940_lanthipeptideNZ_CP116962.1 Lanthipeptides: PO880_RS01555_lanthipeptideNZ_GG670379.1 Lanthipeptides: EFDG_RS12825_lanthipeptideNZ_GL454198.1 Lanthipeptides: HMPREF9500_RS14725_lanthipeptideNZ_KB944666.1 Lanthipeptides: WMS_RS03545_lanthipeptideNZ_KZ845971.1 Lanthipeptides: EB55_RS12315_lanthipeptide

Lanthipeptides: ENT_RS13920_lanthipeptide

1

NDNARISPTIILSAATVASAASSFVGSYTLSAFTKCR

37

NDNARISPTIILSAATVASAASSFVGSYTLSAFTKCR

1

NDNARISPTIILSAATVASAASSFVGSYTLSAFTKCR

37

97.3%

NZ_JTKS01000015.1:

Lanthipeptides: QI17_RS10285_lanthipeptide

1

NDNARISPTIILSAATVASAASSFVGSYTLSAFTKCR

37

NDNARISP IILSAATVASAASSFVGSYTLSAFTKCR

1

NDNARISPKIILSAATVASAASSFVGSYTLSAFTKCR

37

43.2%

NZ_CP044545.1:

Lanthipeptides: F7984_RS17855_lanthipeptide

3

NARISPTIILSAATVASAASSFVGSYTLSA

32

N I P AATV SA +SFVGSY ++A

1

NGEIQPQGT-PAATVISALASFVGSYLVTA

29

with 20 more sequence matches

Only the first 10 are displayed here.

37.8%

NZ_JACSNF010000005.1and 1 other:

NZ_LMPR01000013.1 Lanthipeptides: ASF99_RS16385_lanthipeptide

Lanthipeptides: KNQ12_RS14670_lanthipeptide

7

SPTIILSAATVASAASSFVGSYTLSAFTKC

36

S + + ++ V SA SFVGSY SA KC

1

STDVDVRSSLVCSALLSFVGSYLASAGLKC

30

34.0%

NZ_CP099547.1:

Lanthipeptides: allorf_0559994_0560212_lanthipeptide

7

SPTIILSA---ATVASAASSFVGSYTL----SAFTKCR

37

+PT+ S+ ATV+ A S + S+T+ SA+TKCR

9

TPTVTTSSVPCATVSKAVSGALVSWTVSFVASAWTKCR

46

32.4%

NZ_NVMQ01000017.1:

Lanthipeptides: CON32_RS17790_lanthipeptide

3

NARISPTIILSAATVASAASSFVGSYTLSAFTKC

36

+ R +P+ +L+ SFV SY SA KC

4

DPRTTPSPLLA---------SFVASYIASAEFKC

28

29.7%

NZ_FNYB01000021.1:

Lanthipeptides: BMZ34_RS24355_lanthipeptide

3

NARISPTIILSAATVASAASSFVGSYTLSAFTKC

36

+ R +P+ +L+ SFV SY SA +C

4

DPRTTPSPLLA---------SFVASYIASAEFRC

28

29.7%

NZ_FNYB01000021.1:

Lanthipeptides: BMZ34_RS24360_lanthipeptide

3

NARISPTIILSAATVASAASSFVGSYTLSAFTKC

36

+ R +P+ +L+ SFV SY SA +C

4

DPRTTPSPLLA---------SFVASYIASAQYRC

28

29.7%

NZ_KB976303.1:

Lanthipeptides: IGY_RS26050_lanthipeptide

3

NARISPTIILSAATVASAASSFVGSYTLSAFTKC

36

+ R +P+ +L+ SFV SY SA +C

4

DPRTTPSPLLA---------SFVASYIASAQFRC

28

29.7%

NZ_LT800494.1:

Lanthipeptides: B7E07_RS02625_lanthipeptide

3

NARISPTIILSAATVASAASSFVGSYTLSA

32

+ +PTI L++A V + S+F S T++A

5

EPQATPTIALTSALVGAPVSAF-ASLTITA

33

29.7%

NZ_NAOJ01000022.1:

Lanthipeptides: B5K31_RS08015_lanthipeptide

16

TVASAASSFVGSYTLSAFTKC

36

T+ SA SF+ SY SA T+C

10

TICSATLSFIASYLGSAQTRC

30

27.0%

NC_003028.3and 46 others:

NC_003098.1 Lanthipeptides: SPR_RS08865_lanthipeptideNC_011900.1 Lanthipeptides: SPN23F_RS10050_lanthipeptideNC_012466.1 Lanthipeptides: SPJ_RS09635_lanthipeptideNZ_CFDV01000030.1 Lanthipeptides: AQB43_RS08320_lanthipeptideNZ_CFVJ01000005.1 Lanthipeptides: AP598_RS03265_lanthipeptideNZ_CGGJ01000006.1 Lanthipeptides: AP607_RS03205_lanthipeptideNZ_CHVQ01000007.1 Lanthipeptides: AQF85_RS04285_lanthipeptideNZ_CJZM01000008.1 Lanthipeptides: AEE29_RS04155_lanthipeptideNZ_CLHL01000007.1 Lanthipeptides: AE723_RS05750_lanthipeptideNZ_CMIW01000004.1 Lanthipeptides: AD046_RS04075_lanthipeptideNZ_CMKL01000017.1 Lanthipeptides: AD734_RS09110_lanthipeptideNZ_CP035244.1 Lanthipeptides: EQH36_RS09105_lanthipeptideNZ_CP035253.1 Lanthipeptides: EQH27_RS09740_lanthipeptideNZ_CP082820.1 Lanthipeptides: K8B76_RS08865_lanthipeptideNZ_CPPE01000023.1 Lanthipeptides: AD654_RS06875_lanthipeptideNZ_CPRX01000013.1 Lanthipeptides: AEE77_RS05820_lanthipeptideNZ_CPTT01000011.1 Lanthipeptides: AEH42_RS06000_lanthipeptideNZ_CRAW01000006.1 Lanthipeptides: AK725_RS04395_lanthipeptideNZ_CRXO01000010.1 Lanthipeptides: AKU38_RS05260_lanthipeptideNZ_FCRW01000008.1 Lanthipeptides: A1N73_RS07425_lanthipeptideNZ_FDDE01000015.1 Lanthipeptides: A1A23_RS09705_lanthipeptideNZ_FDFR01000008.1 Lanthipeptides: A1O50_RS09320_lanthipeptideNZ_FDGF01000009.1 Lanthipeptides: A0899_RS06595_lanthipeptideNZ_FDQP01000009.1 Lanthipeptides: A1S42_RS08050_lanthipeptideNZ_FECM01000008.1 Lanthipeptides: A1930_RS06475_lanthipeptideNZ_FEEQ01000001.1 Lanthipeptides: A1T31_RS01145_lanthipeptideNZ_FEOS01000003.1 Lanthipeptides: A1178_RS03085_lanthipeptideNZ_FFTU01000009.1 Lanthipeptides: A1K37_RS06335_lanthipeptideNZ_FHJP02000011.1 Lanthipeptides: A1O79_RS07375_lanthipeptideNZ_FHRS02000028.1 Lanthipeptides: A1898_RS09820_lanthipeptideNZ_FIXQ01000010.1 Lanthipeptides: AZ721_RS04790_lanthipeptideNZ_FZDX01000018.1 Lanthipeptides: CFW91_RS09480_lanthipeptideNZ_FZEI01000008.1 Lanthipeptides: CFW58_RS06410_lanthipeptideNZ_JACVHZ010000010.1 Lanthipeptides: ICJ99_RS03880_lanthipeptideNZ_JAGFAE010000038.1 Lanthipeptides: J5E60_RS09005_lanthipeptideNZ_JALDUX010000010.1 Lanthipeptides: M1F92_RS09535_lanthipeptideNZ_JAMYJM010000002.1 Lanthipeptides: NKE69_RS04885_lanthipeptideNZ_LR216014.1 Lanthipeptides: E0F05_RS09385_lanthipeptideNZ_LR216016.1 Lanthipeptides: E0F10_RS10160_lanthipeptideNZ_LR216019.1 Lanthipeptides: E0E94_RS09635_lanthipeptideNZ_LR216027.1 Lanthipeptides: E0E81_RS09205_lanthipeptideNZ_LR216049.1 Lanthipeptides: E0E96_RS09540_lanthipeptideNZ_LR216064.1 Lanthipeptides: E0F31_RS09525_lanthipeptideNZ_LR536843.1 Lanthipeptides: E0F34_RS09600_lanthipeptideNZ_MRXY01000010.1 Lanthipeptides: BTU63_RS06305_lanthipeptideNZ_NANQ01000003.1 Lanthipeptides: B5K28_RS01935_lanthipeptide

Lanthipeptides: SP_RS09795_lanthipeptide

17

VASAASSFVGSYTLSAFTKC

36

+ SA SF+ SY SA T+C

11

ICSATLSFIASYLGSAQTRC

30

27.0%

NZ_CP041405.1:

Lanthipeptides: FLT43_RS14405_lanthipeptide

17

VASAASSFVGSYTLSAFTKC

36

V A S+V SY SA KC

12

VCGAGISYVASYLASAAFKC

31

allorf_0340612_0340755

Leader:

MLLLIKTYNYLHSYFILKKYGPVNTSLVHIGGA

Core:

PRNICTENSDSDYL

Core with dehydrations:

PRNICysDhbENDhaDDhaDYL

antiSMASH-DB 4.0 matches for allorf_0340612_0340755

100.0%

NC_021023.1and 9 others:

NZ_CABGJL010000002.1 Lanthipeptides: allorf_195639_195782_lanthipeptideNZ_CABGPX010000017.1 Lanthipeptides: allorf_61913_62056_lanthipeptideNZ_CABGTR010000003.1 Lanthipeptides: allorf_127304_127447_lanthipeptideNZ_CP097048.1 Lanthipeptides: allorf_2681863_2682006_lanthipeptideNZ_CP116962.1 Lanthipeptides: allorf_0340612_0340755_lanthipeptideNZ_GL454198.1 Lanthipeptides: allorf_096858_097001_lanthipeptideNZ_JTKS01000015.1 Lanthipeptides: allorf_208570_208713_lanthipeptideNZ_KB944666.1 Lanthipeptides: allorf_0096922_0097065_lanthipeptideNZ_KZ845971.1 Lanthipeptides: allorf_2372960_2373103_lanthipeptide

Lanthipeptides: allorf_2915554_2915697_lanthipeptide

1

PRNICTENSDSDYL

14

PRNICTENSDSDYL

1

PRNICTENSDSDYL

14

22.2%

NZ_CP114875.1:

Lanthipeptides: O4Z47_RS14375_lanthipeptide

3

NICTENSDSDYL

14

+ICT S+ D+L

10

DICTLTSECDHL

21

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 19.00 out of 20.47

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.36 out of 26.06

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 22.72 out of 24.78

Confidence: strong

Additional weak hits (2):

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 24.35 out of 33.73

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.58 out of 29.65

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

PO880_RS01550 - Class II

Cleavage pHMM score: 1.60

RODEO score: 0

Monoisotopic mass: 6038.1 Da

Molecular weight: 6041.7 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 6059.7 Da N = 1; 6077.8 Da N = 2; 6095.8 Da N = 3; 6113.8 Da N = 4; 6131.8 Da N = 5; 6149.8 Da N = 6; 6167.9 Da N = 7; 6185.9 Da N = 8; 6203.9 Da N = 9; 6221.9 Da N = 10; 6239.9 Da N = 11; 6258.0 Da N = 12

PO880_RS01555 - Class II

Cleavage pHMM score: -0.50

RODEO score: 0

Monoisotopic mass: 3591.9 Da

Molecular weight: 3594.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3612.0 Da N = 1; 3630.1 Da N = 2; 3648.1 Da N = 3; 3666.1 Da N = 4; 3684.1 Da N = 5; 3702.1 Da N = 6; 3720.2 Da N = 7; 3738.2 Da N = 8; 3756.2 Da N = 9; 3774.2 Da N = 10

allorf_0340612_0340755 - Class II

Cleavage pHMM score: -4.70

RODEO score: 0

Monoisotopic mass: 1571.7 Da

Molecular weight: 1572.6 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1590.7 Da N = 1; 1608.7 Da N = 2

TFBS definitions

Regulator	Description
LexA variant 2	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
VqsM	Regulator of quorum-sensing signalling systems

NZ_CP116962.1 - Region 2 - lassopeptide

Download region GenBank file

Download region SVG

Location: 995,063 - 1,019,444 nt. (total: 24,382 nt) Show pHMM detection rules used

lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lasso peptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

PO880_RS04770: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: aminotransferase

PO880_RS04695: aminotransferase class V

smcogs: SMCOG1139: aminotransferase class V

Hydrolases: hydrolase

PO880_RS04735: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002575.2	0.64	ribosomal	cochonodin I	Streptococcus suis
BGC0001634.3	0.56	ribosomal	keywimysin	Streptomyces sp. NRRL F-5702
BGC0001496.3	0.56	ribosomal	actinokineosin	Actinokineospora spheciospongiae
BGC0002276.2	0.55	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001552.3	0.53	ribosomal	citrulassin F	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001550.3	0.52	ribosomal	citrulassin D	Streptomyces katrae
BGC0001176.4	0.52	ribosomal	streptomonomicin	Streptomonospora alba
BGC0001549.3	0.52	ribosomal	citrulassin B	Streptomyces aurantiacus JA 4570
BGC0000575.5	0.51	ribosomal	lariatin	Rhodococcus jostii
BGC0001889.2	0.50	ribosomal	fusilassin	Thermobifida fusca YX

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002575.2	0.64	ribosomal	cochonodin I	Streptococcus suis
BGC0001634.3	0.56	ribosomal	keywimysin	Streptomyces sp. NRRL F-5702
BGC0001496.3	0.56	ribosomal	actinokineosin	Actinokineospora spheciospongiae
BGC0002276.2	0.55	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001552.3	0.53	ribosomal	citrulassin F	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001550.3	0.52	ribosomal	citrulassin D	Streptomyces katrae
BGC0001176.4	0.52	ribosomal	streptomonomicin	Streptomonospora alba
BGC0001549.3	0.52	ribosomal	citrulassin B	Streptomyces aurantiacus JA 4570
BGC0000575.5	0.51	ribosomal	lariatin	Rhodococcus jostii
BGC0001889.2	0.50	ribosomal	fusilassin	Thermobifida fusca YX

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lasso peptide predictions

Lassopeptides - No core peptides found.

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.78 out of 20.97

Confidence: strong

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.80 out of 26.33

Confidence: medium

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 28.04 out of 32.74

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.62 out of 24.78

Confidence: medium

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 21.46 out of 27.04

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.16 out of 26.06

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.91 out of 28.19

Confidence: medium

Additional weak hits (1):

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.37 out of 30.98

Confidence: weak

Lasso peptides

RREFinder

TFBS Finder

Core peptide predictions

No core peptides found.

RRE predictions

: RRE type: Stand_Alone_Lasso_RRE; Location: 0 - 82; Score: 75.1

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
CcpA	Catabolite control protein A
DasR	N-acetylglucosamine dependent repressor
FuR variant 2	Ferric Uptake Regulator
LexA variant 2	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
ZuR variant 1	Zinc-responsive repressor

NZ_CP116962.1 - Region 3 - cyclic-lactone-autoinducer

Download region GenBank file

Download region SVG

Location: 1,399,349 - 1,420,077 nt. (total: 20,729 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001291.3	0.41	ribosomal	enterocin NKR-5-3B	Enterococcus faecium
BGC0001948.3	0.37	other (other)	naseseazine C, C3-aryl pyrroloindolines	Streptomyces sp.
BGC0000046.4	0.35	PKS	depudecin	Alternaria brassicicola
BGC0002227.3	0.31	NRPS	AKML B, AKML D, AKML A, AKML C	Aspergillus luchuensis IFO 4308
BGC0002667.2	0.30	ribosomal	estericin A	Clostridium estertheticum
BGC0001246.3	0.30	PKS	trans-resorcylide	Sarocladium zeae
BGC0000688.4	0.29	terpene	copalyl diphosphate	Diaporthe amygdali
BGC0001954.2	0.28	NRPS, PKS	wortmanamide A, wortmanamide B	Talaromyces wortmannii
BGC0001366.5	0.27	PKS	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2
BGC0002058.3	0.27	NRPS, PKS	mutanocyclin	Streptococcus mutans B04Sm5

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001291.3	0.41	ribosomal	enterocin NKR-5-3B	Enterococcus faecium
BGC0001948.3	0.37	other (other)	naseseazine C, C3-aryl pyrroloindolines	Streptomyces sp.
BGC0000046.4	0.35	PKS	depudecin	Alternaria brassicicola
BGC0002227.3	0.31	NRPS	AKML B, AKML D, AKML A, AKML C	Aspergillus luchuensis IFO 4308
BGC0002667.2	0.30	ribosomal	estericin A	Clostridium estertheticum
BGC0001246.3	0.30	PKS	trans-resorcylide	Sarocladium zeae
BGC0000688.4	0.29	terpene	copalyl diphosphate	Diaporthe amygdali
BGC0001954.2	0.28	NRPS, PKS	wortmanamide A, wortmanamide B	Talaromyces wortmannii
BGC0001366.5	0.27	PKS	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2
BGC0002058.3	0.27	NRPS, PKS	mutanocyclin	Streptococcus mutans B04Sm5

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.50 out of 23.79

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.08 out of 23.79

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 28.99 out of 30.25

Confidence: strong

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.55 out of 19.26

Confidence: medium

Additional weak hits (1):

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 20.68 out of 29.72

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
ColR	Phenol-responsive regulator
IolR	Regulator of the inositol catabolism

NZ_CP116962.1 - Region 4 - RiPP-like

Download region GenBank file

Download region SVG

Location: 1,761,086 - 1,771,967 nt. (total: 10,882 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

No matches found.

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.71 out of 29.72

Confidence: medium

TFBS Finder

TFBS definitions

Regulator	Description
NtrC	Nitrogen regulatory protein C
ToxT	Regulator of MSHA biosynthesis

NZ_CP116962.1 - Region 5 - terpene-precursor

Download region GenBank file

Download region SVG

Location: 2,242,162 - 2,263,043 nt. (total: 20,882 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: peptidase

PO880_RS10970: methionine aminopeptidase

smcogs: SMCOG1172: methionine aminopeptidase

Ligases: synthetase

PO880_RS10935: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002309.2	0.36	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000639.3	0.34	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.34	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0001605.3	0.32	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001075.5	0.31	PKS, terpene	aurachin RE	Rhodococcus erythropolis
BGC0001456.3	0.30	terpene	isorenieratene	Streptomyces argillaceus
BGC0000286.3	0.30	PKS	viguiepinol	Streptomyces sp. KO-3988

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002309.2	0.36	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000639.3	0.34	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.34	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0001605.3	0.32	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001075.5	0.31	PKS, terpene	aurachin RE	Rhodococcus erythropolis
BGC0001456.3	0.30	terpene	isorenieratene	Streptomyces argillaceus
BGC0000286.3	0.30	PKS	viguiepinol	Streptomyces sp. KO-3988

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

PO880_RS10935: PT_FPPS_like

Domain 1 (29 - 276): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.38 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.25 out of 27.78

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.87 out of 28.19

Confidence: medium

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ZuR variant 1	Zinc-responsive repressor

NZ_CP116962.1 - Region 6 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 2,700,575 - 2,723,556 nt. (total: 22,982 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: protease

PO880_RS13015: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase

PO880_RS13025: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.99	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000500.5	0.53	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0001407.5	0.52	ribosomal	bicereucin	Bacillus cereus SJ1
BGC0000523.3	0.51	ribosomal	lactocin S	Lactobacillus sakei
BGC0000525.5	0.50	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000623.3	0.49	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000516.4	0.47	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0002698.2	0.47	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0002674.2	0.46	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0001210.5	0.45	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.99	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000500.5	0.53	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0001407.5	0.52	ribosomal	bicereucin	Bacillus cereus SJ1
BGC0000523.3	0.51	ribosomal	lactocin S	Lactobacillus sakei
BGC0000525.5	0.50	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000623.3	0.49	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000516.4	0.47	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0002698.2	0.47	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0002674.2	0.46	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0001210.5	0.45	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for PO880_RS13025

PO880_RS13030

Leader:

MLNKENQENYYSNKLELVGPSFEELSLEEMEAIQGS

Core:

GDVQAETTPACFTIGLGVGALFSAKFC

Core with dehydrations:

GDVQAEDhbDhbPACysFDhbIGLGVGALFDhaAKFCys

antiSMASH-DB 4.0 matches for PO880_RS13030

100.0%

NZ_AP026721.1and 35 others:

NZ_CP015883.1 Lanthipeptides: A6B47_RS00875_lanthipeptideNZ_CP028286.1 Lanthipeptides: CEQ02_RS16115_lanthipeptideNZ_CP028721.1 Lanthipeptides: C7I32_RS15475_lanthipeptideNZ_CP028835.1 Lanthipeptides: C9432_RS02740_lanthipeptideNZ_CP028837.1 Lanthipeptides: C9432_RS15935_lanthipeptideNZ_CP033787.1 Lanthipeptides: EGX75_RS02740_lanthipeptideNZ_CP039296.1 Lanthipeptides: E7T02_RS02755_lanthipeptideNZ_CP045045.1 Lanthipeptides: F9293_RS12755_lanthipeptideNZ_CP075604.2 Lanthipeptides: KKP64_RS02155_lanthipeptideNZ_CP085289.1 Lanthipeptides: LIT95_RS07630_lanthipeptideNZ_CP085291.1 Lanthipeptides: LIT96_RS04335_lanthipeptideNZ_CP085297.1 Lanthipeptides: LIT97_RS14520_lanthipeptideNZ_CP086726.1 Lanthipeptides: LM507_RS03415_lanthipeptideNZ_CP091901.1 Lanthipeptides: L5I17_RS09010_lanthipeptideNZ_CP091905.1 Lanthipeptides: L5I20_RS14940_lanthipeptideNZ_CP091907.1 Lanthipeptides: L5I26_RS13265_lanthipeptideNZ_CP093957.1 Lanthipeptides: MPM64_RS01385_lanthipeptideNZ_CP116962.1 Lanthipeptides: PO880_RS13030_lanthipeptideNZ_JAASJP010000011.1 Lanthipeptides: HCH27_RS13275_lanthipeptideNZ_JAHZNN010000041.1 Lanthipeptides: K0X81_RS16410_lanthipeptideNZ_JAKTAU010000028.1 Lanthipeptides: MKK46_RS14535_lanthipeptideNZ_JALSCL010000035.1 Lanthipeptides: NEI30_RS13375_lanthipeptideNZ_JAQDOF010000024.1 Lanthipeptides: PGP79_RS14595_lanthipeptideNZ_JAQKZU010000014.1 Lanthipeptides: PMV60_RS12615_lanthipeptideNZ_KB932317.1 Lanthipeptides: Q95_RS09840_lanthipeptideNZ_KB932336.1 Lanthipeptides: Q9C_RS13350_lanthipeptideNZ_KB944697.1 Lanthipeptides: WO3_RS18030_lanthipeptideNZ_KB944708.1 Lanthipeptides: WO5_RS05650_lanthipeptideNZ_KB944753.1 Lanthipeptides: WO9_RS06460_lanthipeptideNZ_KB944762.1 Lanthipeptides: WOA_RS17470_lanthipeptideNZ_KB944819.1 Lanthipeptides: WOK_RS14355_lanthipeptideNZ_KB946767.1 Lanthipeptides: UK1_RS12990_lanthipeptideNZ_KB947483.1 Lanthipeptides: WUI_RS10440_lanthipeptideNZ_KZ845881.1 Lanthipeptides: EB41_RS04380_lanthipeptideNZ_NGMY01000001.1 Lanthipeptides: A5862_RS02370_lanthipeptide

Lanthipeptides: PO855_RS02215_lanthipeptide

1

GDVQAETTPACFTIGLGVGALFSAKFC

27

GDVQAETTPACFTIGLGVGALFSAKFC

1

GDVQAETTPACFTIGLGVGALFSAKFC

27

85.2%

NZ_CP011974.1and 2 others:

NZ_CP115914.1 Lanthipeptides: PGN40_RS02040_lanthipeptideNZ_MWSI01000006.1 Lanthipeptides: B1B01_RS20140_lanthipeptide

Lanthipeptides: BEH_RS02100_lanthipeptide

1

GDVQAETTPACFTIGLGVGALFSAKFC

27

GDVQAETTP CFTIGLGVGAL SA C

1

GDVQAETTPVCFTIGLGVGALVSAAGC

27

77.8%

NZ_JH791802.1and 2 others:

NZ_MIFM01000001.1 Lanthipeptides: BHL22_RS00410_lanthipeptideNZ_NINI01000009.1 Lanthipeptides: CEV12_RS07260_lanthipeptide

Lanthipeptides: IKS_RS03655_lanthipeptide

1

GDVQAETTPACFTIGLGVGALFSAKFC

27

GDVQAETTP CFT+GLGVG+L SA C

1

GDVQAETTPVCFTVGLGVGSLVSASVC

27

with 108 more sequence matches

Only the first 10 are displayed here.

74.1%

NZ_JH791802.1and 2 others:

NZ_MIFM01000001.1 Lanthipeptides: BHL22_RS00405_lanthipeptideNZ_NINI01000009.1 Lanthipeptides: CEV12_RS07255_lanthipeptide

Lanthipeptides: IKS_RS03660_lanthipeptide

1

GDVQAETTPACFTIGLGVGALFSAKFC

27

GDVQAETTP CFT+GLG+G+L SA C

1

GDVQAETTPVCFTVGLGIGSLVSASVC

27

71.4%

NZ_KB946334.1:

Lanthipeptides: UC7_RS10230_lanthipeptide

1

GDVQAETTPAC-FTIGLGVGALFSAKFC

27

GDVQ ETTP C FTIG+G+GAL S K+C

1

GDVQPETTPICGFTIGIGIGALASVKWC

28

71.4%

NZ_KB946334.1:

Lanthipeptides: UC7_RS10250_lanthipeptide

1

GDVQAETTPAC-FTIGLGVGALFSAKFC

27

GDVQ ETTP C FTIG+G+GAL S K+C

1

GDVQPETTPLCGFTIGIGIGALVSVKWC

28

70.0%

NZ_NVAW01000030.1and 1 other:

NZ_NVEP01000021.1 Lanthipeptides: COL17_RS24445_lanthipeptide

Lanthipeptides: COK11_RS25885_lanthipeptide

1

GDVQAETTPAC---FTIGLGVGALFSAKFC

27

GDV+ ETTPAC FTIGLG+GAL SA C

1

GDVKPETTPACLAGFTIGLGIGALASAAGC

30

66.7%

NZ_CP025701.1:

Lanthipeptides: C0569_RS26125_lanthipeptide

1

GDVQAETTPAC---FTIGLGVGALFSAKFC

27

GDV+ ETTPAC FT+GLG+GAL SA C

1

GDVKPETTPACLAGFTVGLGIGALASAAGC

30

63.0%

NZ_JACDUU010000003.1:

Lanthipeptides: HNQ85_RS08035_lanthipeptide

1

GDVQAETTPACFTIGLGVGALFSAKFC

27

GDVQ ET+PAC TIG+G+G S FC

1

GDVQPETSPACVTIGIGIGIGISKLFC

27

59.3%

NZ_JAOVZP010000016.1and 3 others:

NZ_NHVL01000036.1 Lanthipeptides: CEU70_RS27720_lanthipeptideNZ_NTYE01000081.1 Lanthipeptides: CN490_RS28165_lanthipeptideNZ_NVMN01000027.1 Lanthipeptides: CON30_RS23205_lanthipeptide

Lanthipeptides: OF830_RS26725_lanthipeptide

1

GDVQAETTPACFTIGLGVGALFSAKFC

27

DVQ ETTPAC T L G +FS K+C

1

SDVQPETTPACVT-ALTTGIIFSIKWC

26

58.6%

NZ_JAOVZP010000016.1and 3 others:

NZ_NHVL01000036.1 Lanthipeptides: CEU70_RS27725_lanthipeptideNZ_NTYE01000081.1 Lanthipeptides: CN490_RS28170_lanthipeptideNZ_NVMN01000027.1 Lanthipeptides: CON30_RS23200_lanthipeptide

Lanthipeptides: OF830_RS26730_lanthipeptide

1

GDVQAETTPAC---FTIGLGVGALFSAKFC

27

DVQ ETTPAC FTIG V +FS + C

1

SDVQPETTPACAVAFTIGATV--IFSVRNC

28

57.1%

NZ_JANFNS010000003.1:

Lanthipeptides: NOM90_RS11325_lanthipeptide

2

DVQAETTPAC-FTIGLGVGALFSAKFC

27

DVQ ETTP C F +G+G+GA+ SA C

2

DVQPETTPVCGFFVGVGIGAIISATAC

28

55.6%

NZ_JACSPU010000002.1:

Lanthipeptides: H9630_RS06775_lanthipeptide

1

GDVQAETTPACFTIGLGVGALFSAKFC

27

DV ETTPAC G LFS KFC

1

SDVAPETTPAC-VAAFATGLLFSIKFC

26

MIBiG 4.0 matches for PO880_RS13030

27.0%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

7

TTPACFTIGLGVGAL-------FSAKFC

27

T PA + LG+ A+ SA FC

1

TDPAVTGLILGIVAIQAGVAVGVSAAFC

28

11.8%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

8

TPACFT

13

TP C T

8

TPGCKT

13

7.8%

BGC0002120.3 (NQE92413.1):

Lanthipeptide: nocathioamide A

9

PACFTIG

15

PAC T+

38

PACHTLS

44

PO880_RS13035

Leader:

MENLSVVPSFEELSVEEMEAIQGS

Core:

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

Core with dehydrations:

GDVQAEDhbDhbPVCysAVAADhbAAADhaDhaAACysGWVGGGIFDhbGVDhbVVVDhaLKHCys

antiSMASH-DB 4.0 matches for PO880_RS13035

100.0%

NZ_AP026721.1and 34 others:

NZ_CP015883.1 Lanthipeptides: A6B47_RS00880_lanthipeptideNZ_CP028286.1 Lanthipeptides: CEQ02_RS16120_lanthipeptideNZ_CP028721.1 Lanthipeptides: C7I32_RS15480_lanthipeptideNZ_CP028835.1 Lanthipeptides: C9432_RS02735_lanthipeptideNZ_CP028837.1 Lanthipeptides: C9432_RS15930_lanthipeptideNZ_CP033787.1 Lanthipeptides: EGX75_RS02745_lanthipeptideNZ_CP039296.1 Lanthipeptides: E7T02_RS02750_lanthipeptideNZ_CP045045.1 Lanthipeptides: F9293_RS12760_lanthipeptideNZ_CP075604.2 Lanthipeptides: KKP64_RS02150_lanthipeptideNZ_CP085289.1 Lanthipeptides: LIT95_RS07625_lanthipeptideNZ_CP085291.1 Lanthipeptides: LIT96_RS04340_lanthipeptideNZ_CP085297.1 Lanthipeptides: LIT97_RS14515_lanthipeptideNZ_CP086726.1 Lanthipeptides: LM507_RS03420_lanthipeptideNZ_CP091901.1 Lanthipeptides: L5I17_RS09015_lanthipeptideNZ_CP091905.1 Lanthipeptides: L5I20_RS14935_lanthipeptideNZ_CP091907.1 Lanthipeptides: L5I26_RS13260_lanthipeptideNZ_CP093957.1 Lanthipeptides: MPM64_RS01390_lanthipeptideNZ_CP116962.1 Lanthipeptides: PO880_RS13035_lanthipeptideNZ_JAASJP010000011.1 Lanthipeptides: HCH27_RS13280_lanthipeptideNZ_JAHZNN010000041.1 Lanthipeptides: K0X81_RS16405_lanthipeptideNZ_JAKTAU010000028.1 Lanthipeptides: MKK46_RS14540_lanthipeptideNZ_JALSCL010000035.1 Lanthipeptides: NEI30_RS13380_lanthipeptideNZ_JAQDOF010000024.1 Lanthipeptides: PGP79_RS14600_lanthipeptideNZ_JAQKZU010000014.1 Lanthipeptides: PMV60_RS12620_lanthipeptideNZ_KB932317.1 Lanthipeptides: Q95_RS09835_lanthipeptideNZ_KB932336.1 Lanthipeptides: Q9C_RS13355_lanthipeptideNZ_KB944697.1 Lanthipeptides: WO3_RS18035_lanthipeptideNZ_KB944708.1 Lanthipeptides: WO5_RS05645_lanthipeptideNZ_KB944753.1 Lanthipeptides: WO9_RS06455_lanthipeptideNZ_KB944762.1 Lanthipeptides: WOA_RS17465_lanthipeptideNZ_KB944819.1 Lanthipeptides: WOK_RS14360_lanthipeptideNZ_KB946767.1 Lanthipeptides: UK1_RS12995_lanthipeptideNZ_KB947483.1 Lanthipeptides: WUI_RS10435_lanthipeptideNZ_KZ845881.1 Lanthipeptides: EB41_RS04385_lanthipeptide

Lanthipeptides: PO855_RS02210_lanthipeptide

1

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

44

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

1

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

44

93.2%

NZ_CP011974.1and 2 others:

NZ_CP115914.1 Lanthipeptides: PGN40_RS02045_lanthipeptideNZ_MWSI01000006.1 Lanthipeptides: B1B01_RS20135_lanthipeptide

Lanthipeptides: BEH_RS02105_lanthipeptide

1

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

44

GDVQAETTPVCA+AATAAASSAACG+VGGGIFTGVTVVVSLK C

1

GDVQAETTPVCAIAATAAASSAACGYVGGGIFTGVTVVVSLKSC

44

90.9%

NZ_CP011974.1and 2 others:

NZ_CP115914.1 Lanthipeptides: PGN40_RS02050_lanthipeptideNZ_MWSI01000006.1 Lanthipeptides: B1B01_RS20130_lanthipeptide

Lanthipeptides: BEH_RS02110_lanthipeptide

1

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

44

GDVQAETTPVCA+AATAAASSAACG+VGGGIFTGVTVVV+LK C

1

GDVQAETTPVCAIAATAAASSAACGYVGGGIFTGVTVVVTLKSC

44

with 107 more sequence matches

Only the first 10 are displayed here.

86.4%

NZ_JH791802.1and 5 others:

NZ_MIFM01000001.1 Lanthipeptides: BHL22_RS00420_lanthipeptideNZ_MIFM01000001.1 Lanthipeptides: BHL22_RS00415_lanthipeptideNZ_NINI01000009.1 Lanthipeptides: CEV12_RS07275_lanthipeptideNZ_NINI01000009.1 Lanthipeptides: CEV12_RS07270_lanthipeptideNZ_NINI01000009.1 Lanthipeptides: CEV12_RS07265_lanthipeptide

Lanthipeptides: IKS_RS30065_lanthipeptide

1

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

44

GDVQAETTPVCA+AAT AASSAACGWVGGGI TGVTVV++LK C

1

GDVQAETTPVCAIAATTAASSAACGWVGGGIATGVTVVITLKSC

44

84.1%

NZ_CP025701.1:

Lanthipeptides: C0569_RS26130_lanthipeptide

1

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

44

GDVQAETTPVCA+AATAAASS C GGGI TGVTVVVSLKHC

1

GDVQAETTPVCAIAATAAASSGICAATGGGIATGVTVVVSLKHC

44

81.8%

NZ_NVAW01000030.1and 1 other:

NZ_NVEP01000021.1 Lanthipeptides: COL17_RS24440_lanthipeptide

Lanthipeptides: COK11_RS25880_lanthipeptide

1

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

44

GDVQAETTPVCAVAATAAASS C G GI TGVTVVVSLK C

1

GDVQAETTPVCAVAATAAASSGVCAATGAGIATGVTVVVSLKSC

44

77.3%

NZ_MIFM01000001.1and 1 other:

NZ_NINI01000009.1 Lanthipeptides: CEV12_RS07280_lanthipeptide

Lanthipeptides: BHL22_RS00425_lanthipeptide

1

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

44

GDVQAETTPVCAV+ SSAACGWV GGI TGVTVVV+LK C

1

GDVQAETTPVCAVSVATMTSSAACGWVAGGIATGVTVVVTLKSC

44

72.7%

NZ_CP062165.1and 5 others:

NZ_CP062165.1 Lanthipeptides: JNUCC31_RS17165_lanthipeptideNZ_QICW01000005.1 Lanthipeptides: DEU73_RS14625_lanthipeptideNZ_QICW01000005.1 Lanthipeptides: DEU73_RS14625_lanthipeptideNZ_QLLI01000007.1 Lanthipeptides: DET54_RS17330_lanthipeptideNZ_QLLI01000007.1 Lanthipeptides: DET54_RS17330_lanthipeptide

Lanthipeptides: JNUCC31_RS17165_lanthipeptide

1

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

44

GDVQ ETTPVCAVAAT AASSA C VGGGI GVT+V+++K C

1

GDVQPETTPVCAVAATVAASSATCAAVGGGIAVGVTIVLTIKSC

44

72.7%

NZ_JANFNS010000003.1:

Lanthipeptides: NOM90_RS11330_lanthipeptide

1

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

44

DVQ ETTPVCAVAAT AASSA C VGGG+ GVTVV++LK C

1

ADVQPETTPVCAVAATVAASSATCAAVGGGVAVGVTVVLTLKTC

44

70.5%

NZ_KB946334.1and 1 other:

NZ_KB946334.1 Lanthipeptides: UC7_RS10235_lanthipeptide

Lanthipeptides: UC7_RS10245_lanthipeptide

1

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

44

GDVQAETTPVCA++AT AASSAAC VG GI TG+T+V++ K C

1

GDVQAETTPVCAISATVAASSAACAGVGAGIGTGITIVLTFKRC

44

68.2%

NZ_KB946334.1:

Lanthipeptides: UC7_RS10240_lanthipeptide

1

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

44

GDVQ ETTPVCA++AT AASSAAC VG GI TG+T+V++ K C

1

GDVQVETTPVCAISATVAASSAACAGVGAGIGTGITIVLTFKRC

44

68.2%

NZ_LN831278.1:

Lanthipeptides: BN1360_RS08835_lanthipeptide

2

DVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

44

DVQ ETTP+CAVAAT AASSA C VGGGI GVT+V+++K C

2

DVQPETTPICAVAATVAASSATCAAVGGGIAVGVTIVLTIKSC

44

65.9%

NC_014098.1:

Lanthipeptides: BTUS_RS14190_lanthipeptide

1

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

44

GDVQAETTP+C AAT ASSAAC VG GI GVT+V+++K C

1

GDVQAETTPICYTAATVTASSAACAGVGAGIVAGVTIVLTIKRC

44

PO880_RS13075

Leader:

MKEDKIHVLSLFISSIVLFLITIIFHEIAIG

Core:

LVIALICFPISNSIAKKGSVAKFSKKSILV

Core with dehydrations:

LVIALICysFPIDhaNDhaIAKKGDhaVAKFDhaKKDhaILV

antiSMASH-DB 4.0 matches for PO880_RS13075

100.0%

NZ_AP026721.1and 9 others:

NZ_CP028835.1 Lanthipeptides: C9432_RS02690_lanthipeptideNZ_CP039296.1 Lanthipeptides: E7T02_RS02710_lanthipeptideNZ_CP045045.1 Lanthipeptides: F9293_RS12790_lanthipeptideNZ_CP085289.1 Lanthipeptides: LIT95_RS07585_lanthipeptideNZ_CP085291.1 Lanthipeptides: LIT96_RS04380_lanthipeptideNZ_CP086726.1 Lanthipeptides: LM507_RS03460_lanthipeptideNZ_CP093957.1 Lanthipeptides: MPM64_RS01420_lanthipeptideNZ_CP116962.1 Lanthipeptides: PO880_RS13075_lanthipeptideNZ_NGMY01000001.1 Lanthipeptides: A5862_RS02320_lanthipeptide

Lanthipeptides: PO855_RS02170_lanthipeptide

1

LVIALICFPISNSIAKKGSVAKFSKKSILV

30

LVIALICFPISNSIAKKGSVAKFSKKSILV

1

LVIALICFPISNSIAKKGSVAKFSKKSILV

30

9.7%

NZ_CP011152.1and 1 other:

NZ_CP011152.1 Lanthipeptides: WR47_RS28810_lanthipeptide

Lanthipeptides: WR47_RS28810_lanthipeptide

10

ISNSIAKKGSVAKFSKK

26

ISN++ KG +K+

40

ISNTLGNKGHACTITKE

56

allorf_2717161_2717226

Leader:

MVTMLLQFLLYQPGA

Core:

SIILCK

Core with dehydrations:

DhaIILCysK

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.29 out of 29.38

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26

Confidence: medium

Additional weak hits (4):

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 15.65 out of 18.46

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.88 out of 25.75

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 24.30 out of 35.63

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 16.36 out of 30.12

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

PO880_RS13030 - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 2630.3 Da

Molecular weight: 2632.0 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2650.0 Da N = 1; 2668.0 Da N = 2

PO880_RS13035 - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 4017.0 Da

Molecular weight: 4019.5 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 4037.6 Da N = 1; 4055.6 Da N = 2; 4073.6 Da N = 3; 4091.6 Da N = 4; 4109.6 Da N = 5

PO880_RS13075 - Class II

Cleavage pHMM score: -7.10

RODEO score: 0

Monoisotopic mass: 3083.9 Da

Molecular weight: 3085.8 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3103.8 Da N = 1; 3121.9 Da N = 2; 3139.9 Da N = 3; 3157.9 Da N = 4

allorf_2717161_2717226 - Class II

Cleavage pHMM score: -7.30

RODEO score: 0

Monoisotopic mass: 657.4 Da

Molecular weight: 657.9 Da

Number of bridges: 1

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
FuR variant 1	Ferric Uptake Regulator