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Overview
1.1
1.2
1.3
1.4
1.5
1.6

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP116962.1 (Enterococcus faecalis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | lanthipeptide-class-ii | 324,027 | 347,011 |
Region 1.2 | lassopeptide | 995,063 | 1,019,444 | Low | cochonodin I | ribosomal:RiPP
Region 1.3 | cyclic-lactone-autoinducer | 1,399,349 | 1,420,077 |
Region 1.4 | RiPP-like | 1,761,086 | 1,771,967 |
Region 1.5 | terpene-precursor | 2,242,162 | 2,263,043 |
Region 1.6 | lanthipeptide-class-ii | 2,700,575 | 2,723,556 | High | cytolysin ClyLl/cytolysin ClyLs | ribosomal:RiPP:Lanthipeptide

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | lanthipeptide-class-ii | 324,027 | 347,011 |
Region 1.2 | lassopeptide | 995,063 | 1,019,444 | Low | cochonodin I | ribosomal:RiPP
Region 1.3 | cyclic-lactone-autoinducer | 1,399,349 | 1,420,077 |
Region 1.4 | RiPP-like | 1,761,086 | 1,771,967 |
Region 1.5 | terpene-precursor | 2,242,162 | 2,263,043 |
Region 1.6 | lanthipeptide-class-ii | 2,700,575 | 2,723,556 | High | cytolysin ClyLl/cytolysin ClyLs | ribosomal:RiPP:Lanthipeptide

No secondary metabolite regions were found in these records:
  NZ_CP116966.1 (Enterococcus faecalis)
  NZ_CP116963.1 (Enterococcus faecalis)
  NZ_CP116964.1 (Enterococcus faecalis)
  NZ_CP116965.1 (Enterococcus faecalis)

Compact view
NZ_CP116962.1 - Region 1 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 324,027 - 347,011 nt. (total: 22,985 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
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Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: deacetylase
PO880_RS01510: acetylornithine deacetylase

smcogs
  SMCOG1247: acetylornithine deacetylase

Lyases: cyclase
PO880_RS01560: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000504.5 |  | 0.56 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000500.5 |  | 0.51 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000516.4 |  | 0.49 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000623.3 |  | 0.48 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000558.5 |  | 0.48 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000521.3 |  | 0.48 | ribosomal | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0002698.2 |  | 0.46 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0000626.3 |  | 0.45 | ribosomal | thuricin | Bacillus thuringiensis
BGC0001210.5 |  | 0.45 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0001407.5 |  | 0.44 | ribosomal | bicereucin | Bacillus cereus SJ1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000504.5 |  | 0.56 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000500.5 |  | 0.51 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000516.4 |  | 0.49 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000623.3 |  | 0.48 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000558.5 |  | 0.48 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000521.3 |  | 0.48 | ribosomal | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0002698.2 |  | 0.46 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0000626.3 |  | 0.45 | ribosomal | thuricin | Bacillus thuringiensis
BGC0001210.5 |  | 0.45 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0001407.5 |  | 0.44 | ribosomal | bicereucin | Bacillus cereus SJ1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for PO880_RS01560

PO880_RS01550
Leader:
MEAEKIVGM
Core:
Q F E D L S K E E M N F I A G G N N N A R I S P T I V T P V T P Y T S Y V A S A A G S A A L S A V S G L V S Y T K K C F
Core with dehydrations:
Q F E D L Dha K E E M N F I A G G N N N A R I Dha P Dhb I V Dhb P V Dhb P Y Dhb Dha Y V A Dha A A G Dha A A L Dha A V Dha G L V Dha Y Dhb K K Cys F

#### antiSMASH-DB 4.0 matches for PO880_RS01550

100.0%
NC_021023.1 and 10 others:
NZ_CABGJL010000002.1 Lanthipeptides: FN048_RS03100_lanthipeptide NZ_CABGPX010000017.1 Lanthipeptides: FN189_RS10930_lanthipeptide NZ_CABGTR010000003.1 Lanthipeptides: FN307_RS09560_lanthipeptide NZ_CP097048.1 Lanthipeptides: M2906_RS12945_lanthipeptide NZ_CP116962.1 Lanthipeptides: PO880_RS01550_lanthipeptide NZ_GG670379.1 Lanthipeptides: EFDG_RS12820_lanthipeptide NZ_GL454198.1 Lanthipeptides: HMPREF9500_RS14730_lanthipeptide NZ_JTKS01000015.1 Lanthipeptides: QI17_RS10290_lanthipeptide NZ_KB944666.1 Lanthipeptides: WMS_RS03550_lanthipeptide NZ_KZ845971.1 Lanthipeptides: EB55_RS12320_lanthipeptide
Lanthipeptides: ENT_RS13925_lanthipeptide
1
Q F E D L S K E E M N F I A G G N N N A R I S P T I V T P V T P Y T S Y V A S A A G S A A L S A V S G L V S Y T K K C F
60
Q F E D L S K E E M N F I A G G N N N A R I S P T I V T P V T P Y T S Y V A S A A G S A A L S A V S G L V S Y T K K C F
1
Q F E D L S K E E M N F I A G G N N N A R I S P T I V T P V T P Y T S Y V A S A A G S A A L S A V S G L V S Y T K K C F
60
35.0%
NZ_GG730336.1:
Lanthipeptides: SAUG_RS08755_lanthipeptide
16
G N N N A R I S P T I V T P V T P Y T S Y V A S A A G S A A L S A V S G L V S Y T K K C F
60
G + +P T I +P T P Y ++ A +S A V S G L V S Y T K C
2
G T V E P Q A T P T I A S P F T P Y A I E I S I G A---T V S A V S G L V S Y T K D C L
43
30.0%
NZ_FPCC01000026.1:
Lanthipeptides: BM377_RS12905_lanthipeptide
2
F E D L S K E E M N F I A G-G N N N A R I S P T I V T P V T P Y T S Y V A S A A G S A A L S A V S
50
F E D L+ E+M G G+ +A +P I+ P S A + A L S +S
2
F E D L N T E D M Q N T Q G A G D V D A E T T P V I M----P I C S P S A V V N P T L A L S L I S
47
with 25 more sequence matches
Only the first 10 are displayed here.
28.3%
NZ_FPCC01000026.1:
Lanthipeptides: BM377_RS12900_lanthipeptide
2
F E D L S K E E M-N F I A G G N N N A R I S P T I--V T P V T P Y T S
35
F E D L+ E+M N G G+ N A T I +T V P S
2
F E D L N T E D M Q N T Q G G G D V N A E T I V T I S N L T L V G P I V S
38
28.3%
NZ_JACSPZ010000014.1:
Lanthipeptides: H9635_RS18390_lanthipeptide
30
V T P Y T S Y V A S A A G S A------A L S A V S G L V S Y T K K C F
60
V P+T+ + S A A + A+S A+S G L V S Y K C
4
V E P H T T P I L S A A T K S S K K C L G A I S A I S G L V S Y N K D C L
40
27.4%
NZ_CP011152.1 and 1 other:
NZ_CP011152.1 Lanthipeptides: WR47_RS28810_lanthipeptide
Lanthipeptides: WR47_RS28810_lanthipeptide
2
F E D L S K E E M-N F I A G G N N N A R I S P T-I V T P V T P Y T S Y V A S A A G S A A L S A V S G L V S Y T K K C
59
E++ E+ N + G+ A S I+T P T P S G A + T K+C
6
L E E I Q G N E L L N A V G A G D V Q A N T S T V Q I L T P R T P I I S N T L G N K G H A C--------T I T K E C
57
26.7%
NC_021023.1 and 9 others:
NZ_CABGJL010000002.1 Lanthipeptides: FN048_RS03095_lanthipeptide NZ_CABGPX010000017.1 Lanthipeptides: FN189_RS10935_lanthipeptide NZ_CABGTR010000003.1 Lanthipeptides: FN307_RS09565_lanthipeptide NZ_CP097048.1 Lanthipeptides: M2906_RS12940_lanthipeptide NZ_CP116962.1 Lanthipeptides: PO880_RS01555_lanthipeptide NZ_GG670379.1 Lanthipeptides: EFDG_RS12825_lanthipeptide NZ_GL454198.1 Lanthipeptides: HMPREF9500_RS14725_lanthipeptide NZ_KB944666.1 Lanthipeptides: WMS_RS03545_lanthipeptide NZ_KZ845971.1 Lanthipeptides: EB55_RS12315_lanthipeptide
Lanthipeptides: ENT_RS13920_lanthipeptide
17
N N N A R I S P T I V T P V T P Y T S Y V A S A A G S A A L S A V S
50
N+N A R I S P T I+ S +S G S L S A +
1
N D N A R I S P T I I L S A A T V A S A A S S F V G S Y T L S A F T
34
26.7%
NZ_BMSZ01000006.1 and 4 others:
NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12790_lanthipeptide NZ_CP021707.1 Lanthipeptides: CCZ36_RS18195_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19730_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19730_lanthipeptide
Lanthipeptides: IE135_RS12790_lanthipeptide
20
A R I S P T I V T P V T P Y T S Y V A S A A G S A A L S A V S G L V S Y T K K C
59
A I+P T I V P T T+ + A S A A+ T K+C
6
A G I T P T I V-P A T A V T T V I V G A--S A A M Q G G C P T S G C T K R C
42
26.7%
NZ_CP026035.1:
Lanthipeptides: C2H96_RS00305_lanthipeptide
31
T P Y T S Y V A S A A G-------S A A L S A V S G L V S Y T K K C F
60
T P S V S A G S S A+S G+V S+ K C
8
T P A V S A V L S A V G R S T R L C I S G I G S A I S G I V S H N K D C L
44
26.7%
NZ_FPCC01000026.1:
Lanthipeptides: BM377_RS12915_lanthipeptide
2
F E D L S K E E M N F I A G G N N N A R I S P T I V T P V T P Y T S Y V A S A A G S A A L S A V S G L V S Y T K K C F
60
+E D L+ E+M G + + T+ +T A S +S G +S K K C
2
Y E D L N T E D M Q N T Q G A G D T E--A E T V S L A I T-----------G A I A S V I S G A I S L-K K C V
46
26.7%
NZ_KN125582.1:
Lanthipeptides: DJ91_RS27550_lanthipeptide
19
N A R I S P T I V T P V T P Y T S Y V A S A A G S A A L S A V S G L V S Y T K K C F
60
+ R P T++ S ++S A ++ +S A+S G L V S Y K C
4
D T R T H P T V I V-----V S R I S S A K C A S T I S A I S G L V S Y N K D C L
40
25.0%
NZ_CP011152.1 and 3 others:
NZ_CP011152.1 Lanthipeptides: WR47_RS28830_lanthipeptide NZ_CP011152.1 Lanthipeptides: WR47_RS28835_lanthipeptide NZ_CP011152.1 Lanthipeptides: WR47_RS28830_lanthipeptide
Lanthipeptides: WR47_RS28835_lanthipeptide
27
V T P-V T P Y T S Y V A S A A G S A A L S A V S G L V S Y T K K C
59
V T P T P + +A+A A G A +S A V + + K C
3
V T P Q A T P T V T I L A T A A G G A V I S A V L P T L K C S S K C
36
25.0%
NZ_CP094446.1:
Lanthipeptides: L3476_RS23825_lanthipeptide
25
T I V T P V T P Y T S Y V A S A A G S A A L S A V S G L V S Y T K K C F
60
T I V+ V T + S A G S A +S G++S+ K C
11
T I V S A V T R S S K P C I S A I G S A----I S G I I S H N K D C L
42

#### MIBiG 4.0 matches for PO880_RS01550

11.7%
BGC0002130.3 (QKI29070.1):
Lanthipeptide: cacaoidin
29
P V T P Y T S Y V A S A A G S A A L
46
P T Y S A S + +A+
4
P C T I Y A S V S A S I S A T A S W
21
6.7%
BGC0000582.4 (ADR72962.1):
Linaridin: cypemycin
28
T P V T P
32
T P T P
2
T P A T P
6
PO880_RS01555
Leader:
MDEKQLDSLVGQKFEDLSKEEMNFIAGG
Core:
N D N A R I S P T I I L S A A T V A S A A S S F V G S Y T L S A F T K C R
Core with dehydrations:
N D N A R I Dha P Dhb I I L Dha A A Dhb V A Dha A A Dha Dha F V G Dha Y Dhb L Dha A F Dhb K Cys R

#### antiSMASH-DB 4.0 matches for PO880_RS01555

100.0%
NC_021023.1 and 9 others:
NZ_CABGJL010000002.1 Lanthipeptides: FN048_RS03095_lanthipeptide NZ_CABGPX010000017.1 Lanthipeptides: FN189_RS10935_lanthipeptide NZ_CABGTR010000003.1 Lanthipeptides: FN307_RS09565_lanthipeptide NZ_CP097048.1 Lanthipeptides: M2906_RS12940_lanthipeptide NZ_CP116962.1 Lanthipeptides: PO880_RS01555_lanthipeptide NZ_GG670379.1 Lanthipeptides: EFDG_RS12825_lanthipeptide NZ_GL454198.1 Lanthipeptides: HMPREF9500_RS14725_lanthipeptide NZ_KB944666.1 Lanthipeptides: WMS_RS03545_lanthipeptide NZ_KZ845971.1 Lanthipeptides: EB55_RS12315_lanthipeptide
Lanthipeptides: ENT_RS13920_lanthipeptide
1
N D N A R I S P T I I L S A A T V A S A A S S F V G S Y T L S A F T K C R
37
N D N A R I S P T I I L S A A T V A S A A S S F V G S Y T L S A F T K C R
1
N D N A R I S P T I I L S A A T V A S A A S S F V G S Y T L S A F T K C R
37
97.3%
NZ_JTKS01000015.1:
Lanthipeptides: QI17_RS10285_lanthipeptide
1
N D N A R I S P T I I L S A A T V A S A A S S F V G S Y T L S A F T K C R
37
N D N A R I S P I I L S A A T V A S A A S S F V G S Y T L S A F T K C R
1
N D N A R I S P K I I L S A A T V A S A A S S F V G S Y T L S A F T K C R
37
43.2%
NZ_CP044545.1:
Lanthipeptides: F7984_RS17855_lanthipeptide
3
N A R I S P T I I L S A A T V A S A A S S F V G S Y T L S A
32
N I P A A T V S A +S F V G S Y ++A
1
N G E I Q P Q G T-P A A T V I S A L A S F V G S Y L V T A
29
with 20 more sequence matches
Only the first 10 are displayed here.
37.8%
NZ_JACSNF010000005.1 and 1 other:
NZ_LMPR01000013.1 Lanthipeptides: ASF99_RS16385_lanthipeptide
Lanthipeptides: KNQ12_RS14670_lanthipeptide
7
S P T I I L S A A T V A S A A S S F V G S Y T L S A F T K C
36
S + + ++ V S A S F V G S Y S A K C
1
S T D V D V R S S L V C S A L L S F V G S Y L A S A G L K C
30
34.0%
NZ_CP099547.1:
Lanthipeptides: allorf_0559994_0560212_lanthipeptide
7
S P T I I L S A---A T V A S A A S S F V G S Y T L----S A F T K C R
37
+P T+ S+ A T V+ A S + S+T+ S A+T K C R
9
T P T V T T S S V P C A T V S K A V S G A L V S W T V S F V A S A W T K C R
46
32.4%
NZ_NVMQ01000017.1:
Lanthipeptides: CON32_RS17790_lanthipeptide
3
N A R I S P T I I L S A A T V A S A A S S F V G S Y T L S A F T K C
36
+ R +P+ +L+ S F V S Y S A K C
4
D P R T T P S P L L A---------S F V A S Y I A S A E F K C
28
29.7%
NZ_FNYB01000021.1:
Lanthipeptides: BMZ34_RS24355_lanthipeptide
3
N A R I S P T I I L S A A T V A S A A S S F V G S Y T L S A F T K C
36
+ R +P+ +L+ S F V S Y S A +C
4
D P R T T P S P L L A---------S F V A S Y I A S A E F R C
28
29.7%
NZ_FNYB01000021.1:
Lanthipeptides: BMZ34_RS24360_lanthipeptide
3
N A R I S P T I I L S A A T V A S A A S S F V G S Y T L S A F T K C
36
+ R +P+ +L+ S F V S Y S A +C
4
D P R T T P S P L L A---------S F V A S Y I A S A Q Y R C
28
29.7%
NZ_KB976303.1:
Lanthipeptides: IGY_RS26050_lanthipeptide
3
N A R I S P T I I L S A A T V A S A A S S F V G S Y T L S A F T K C
36
+ R +P+ +L+ S F V S Y S A +C
4
D P R T T P S P L L A---------S F V A S Y I A S A Q F R C
28
29.7%
NZ_LT800494.1:
Lanthipeptides: B7E07_RS02625_lanthipeptide
3
N A R I S P T I I L S A A T V A S A A S S F V G S Y T L S A
32
+ +P T I L++A V + S+F S T++A
5
E P Q A T P T I A L T S A L V G A P V S A F-A S L T I T A
33
29.7%
NZ_NAOJ01000022.1:
Lanthipeptides: B5K31_RS08015_lanthipeptide
16
T V A S A A S S F V G S Y T L S A F T K C
36
T+ S A S F+ S Y S A T+C
10
T I C S A T L S F I A S Y L G S A Q T R C
30
27.0%
NC_003028.3 and 46 others:
NC_003098.1 Lanthipeptides: SPR_RS08865_lanthipeptide NC_011900.1 Lanthipeptides: SPN23F_RS10050_lanthipeptide NC_012466.1 Lanthipeptides: SPJ_RS09635_lanthipeptide NZ_CFDV01000030.1 Lanthipeptides: AQB43_RS08320_lanthipeptide NZ_CFVJ01000005.1 Lanthipeptides: AP598_RS03265_lanthipeptide NZ_CGGJ01000006.1 Lanthipeptides: AP607_RS03205_lanthipeptide NZ_CHVQ01000007.1 Lanthipeptides: AQF85_RS04285_lanthipeptide NZ_CJZM01000008.1 Lanthipeptides: AEE29_RS04155_lanthipeptide NZ_CLHL01000007.1 Lanthipeptides: AE723_RS05750_lanthipeptide NZ_CMIW01000004.1 Lanthipeptides: AD046_RS04075_lanthipeptide NZ_CMKL01000017.1 Lanthipeptides: AD734_RS09110_lanthipeptide NZ_CP035244.1 Lanthipeptides: EQH36_RS09105_lanthipeptide NZ_CP035253.1 Lanthipeptides: EQH27_RS09740_lanthipeptide NZ_CP082820.1 Lanthipeptides: K8B76_RS08865_lanthipeptide NZ_CPPE01000023.1 Lanthipeptides: AD654_RS06875_lanthipeptide NZ_CPRX01000013.1 Lanthipeptides: AEE77_RS05820_lanthipeptide NZ_CPTT01000011.1 Lanthipeptides: AEH42_RS06000_lanthipeptide NZ_CRAW01000006.1 Lanthipeptides: AK725_RS04395_lanthipeptide NZ_CRXO01000010.1 Lanthipeptides: AKU38_RS05260_lanthipeptide NZ_FCRW01000008.1 Lanthipeptides: A1N73_RS07425_lanthipeptide NZ_FDDE01000015.1 Lanthipeptides: A1A23_RS09705_lanthipeptide NZ_FDFR01000008.1 Lanthipeptides: A1O50_RS09320_lanthipeptide NZ_FDGF01000009.1 Lanthipeptides: A0899_RS06595_lanthipeptide NZ_FDQP01000009.1 Lanthipeptides: A1S42_RS08050_lanthipeptide NZ_FECM01000008.1 Lanthipeptides: A1930_RS06475_lanthipeptide NZ_FEEQ01000001.1 Lanthipeptides: A1T31_RS01145_lanthipeptide NZ_FEOS01000003.1 Lanthipeptides: A1178_RS03085_lanthipeptide NZ_FFTU01000009.1 Lanthipeptides: A1K37_RS06335_lanthipeptide NZ_FHJP02000011.1 Lanthipeptides: A1O79_RS07375_lanthipeptide NZ_FHRS02000028.1 Lanthipeptides: A1898_RS09820_lanthipeptide NZ_FIXQ01000010.1 Lanthipeptides: AZ721_RS04790_lanthipeptide NZ_FZDX01000018.1 Lanthipeptides: CFW91_RS09480_lanthipeptide NZ_FZEI01000008.1 Lanthipeptides: CFW58_RS06410_lanthipeptide NZ_JACVHZ010000010.1 Lanthipeptides: ICJ99_RS03880_lanthipeptide NZ_JAGFAE010000038.1 Lanthipeptides: J5E60_RS09005_lanthipeptide NZ_JALDUX010000010.1 Lanthipeptides: M1F92_RS09535_lanthipeptide NZ_JAMYJM010000002.1 Lanthipeptides: NKE69_RS04885_lanthipeptide NZ_LR216014.1 Lanthipeptides: E0F05_RS09385_lanthipeptide NZ_LR216016.1 Lanthipeptides: E0F10_RS10160_lanthipeptide NZ_LR216019.1 Lanthipeptides: E0E94_RS09635_lanthipeptide NZ_LR216027.1 Lanthipeptides: E0E81_RS09205_lanthipeptide NZ_LR216049.1 Lanthipeptides: E0E96_RS09540_lanthipeptide NZ_LR216064.1 Lanthipeptides: E0F31_RS09525_lanthipeptide NZ_LR536843.1 Lanthipeptides: E0F34_RS09600_lanthipeptide NZ_MRXY01000010.1 Lanthipeptides: BTU63_RS06305_lanthipeptide NZ_NANQ01000003.1 Lanthipeptides: B5K28_RS01935_lanthipeptide
Lanthipeptides: SP_RS09795_lanthipeptide
17
V A S A A S S F V G S Y T L S A F T K C
36
+ S A S F+ S Y S A T+C
11
I C S A T L S F I A S Y L G S A Q T R C
30
27.0%
NZ_CP041405.1:
Lanthipeptides: FLT43_RS14405_lanthipeptide
17
V A S A A S S F V G S Y T L S A F T K C
36
V A S+V S Y S A K C
12
V C G A G I S Y V A S Y L A S A A F K C
31
allorf_0340612_0340755
Leader:
MLLLIKTYNYLHSYFILKKYGPVNTSLVHIGGA
Core:
P R N I C T E N S D S D Y L
Core with dehydrations:
P R N I Cys Dhb E N Dha D Dha D Y L

#### antiSMASH-DB 4.0 matches for allorf_0340612_0340755

100.0%
NC_021023.1 and 9 others:
NZ_CABGJL010000002.1 Lanthipeptides: allorf_195639_195782_lanthipeptide NZ_CABGPX010000017.1 Lanthipeptides: allorf_61913_62056_lanthipeptide NZ_CABGTR010000003.1 Lanthipeptides: allorf_127304_127447_lanthipeptide NZ_CP097048.1 Lanthipeptides: allorf_2681863_2682006_lanthipeptide NZ_CP116962.1 Lanthipeptides: allorf_0340612_0340755_lanthipeptide NZ_GL454198.1 Lanthipeptides: allorf_096858_097001_lanthipeptide NZ_JTKS01000015.1 Lanthipeptides: allorf_208570_208713_lanthipeptide NZ_KB944666.1 Lanthipeptides: allorf_0096922_0097065_lanthipeptide NZ_KZ845971.1 Lanthipeptides: allorf_2372960_2373103_lanthipeptide
Lanthipeptides: allorf_2915554_2915697_lanthipeptide
1
P R N I C T E N S D S D Y L
14
P R N I C T E N S D S D Y L
1
P R N I C T E N S D S D Y L
14
22.2%
NZ_CP114875.1:
Lanthipeptides: O4Z47_RS14375_lanthipeptide
3
N I C T E N S D S D Y L
14
+I C T S+ D+L
10
D I C T L T S E C D H L
21

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 19.00 out of 20.47
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.36 out of 26.06
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 22.72 out of 24.78
Confidence: strong
Additional weak hits (2):
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 24.35 out of 33.73
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.58 out of 29.65
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

PO880_RS01550 - Class II
  Cleavage pHMM score: 1.60
  RODEO score: 0
  Monoisotopic mass: 6038.1 Da
  Molecular weight: 6041.7 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    6059.7 Da N = 1
    6077.8 Da N = 2
    6095.8 Da N = 3
    6113.8 Da N = 4
    6131.8 Da N = 5
    6149.8 Da N = 6
    6167.9 Da N = 7
    6185.9 Da N = 8
    6203.9 Da N = 9
    6221.9 Da N = 10
    6239.9 Da N = 11
    6258.0 Da N = 12
PO880_RS01555 - Class II
  Cleavage pHMM score: -0.50
  RODEO score: 0
  Monoisotopic mass: 3591.9 Da
  Molecular weight: 3594.0 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3612.0 Da N = 1
    3630.1 Da N = 2
    3648.1 Da N = 3
    3666.1 Da N = 4
    3684.1 Da N = 5
    3702.1 Da N = 6
    3720.2 Da N = 7
    3738.2 Da N = 8
    3756.2 Da N = 9
    3774.2 Da N = 10
allorf_0340612_0340755 - Class II
  Cleavage pHMM score: -4.70
  RODEO score: 0
  Monoisotopic mass: 1571.7 Da
  Molecular weight: 1572.6 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1590.7 Da N = 1
    1608.7 Da N = 2

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
LexA variant 2 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
VqsM | Regulator of quorum-sensing signalling systems

NZ_CP116962.1 - Region 2 - lassopeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 995,063 - 1,019,444 nt. (total: 24,382 nt) Show pHMM detection rules used
lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lasso peptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
PO880_RS04770: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: aminotransferase
PO880_RS04695: aminotransferase class V

smcogs
  SMCOG1139: aminotransferase class V

Hydrolases: hydrolase
PO880_RS04735: asparagine synthase (glutamine-hydrolyzing)

smcogs
  SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lassopeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002575.2 |  | 0.64 | ribosomal | cochonodin I | Streptococcus suis
BGC0001634.3 |  | 0.56 | ribosomal | keywimysin | Streptomyces sp. NRRL F-5702
BGC0001496.3 |  | 0.56 | ribosomal | actinokineosin | Actinokineospora spheciospongiae
BGC0002276.2 |  | 0.55 | NRPS | choline | Aspergillus nidulans FGSC A4
BGC0001552.3 |  | 0.53 | ribosomal | citrulassin F | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001550.3 |  | 0.52 | ribosomal | citrulassin D | Streptomyces katrae
BGC0001176.4 |  | 0.52 | ribosomal | streptomonomicin | Streptomonospora alba
BGC0001549.3 |  | 0.52 | ribosomal | citrulassin B | Streptomyces aurantiacus JA 4570
BGC0000575.5 |  | 0.51 | ribosomal | lariatin | Rhodococcus jostii
BGC0001889.2 |  | 0.50 | ribosomal | fusilassin | Thermobifida fusca YX

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002575.2 |  | 0.64 | ribosomal | cochonodin I | Streptococcus suis
BGC0001634.3 |  | 0.56 | ribosomal | keywimysin | Streptomyces sp. NRRL F-5702
BGC0001496.3 |  | 0.56 | ribosomal | actinokineosin | Actinokineospora spheciospongiae
BGC0002276.2 |  | 0.55 | NRPS | choline | Aspergillus nidulans FGSC A4
BGC0001552.3 |  | 0.53 | ribosomal | citrulassin F | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001550.3 |  | 0.52 | ribosomal | citrulassin D | Streptomyces katrae
BGC0001176.4 |  | 0.52 | ribosomal | streptomonomicin | Streptomonospora alba
BGC0001549.3 |  | 0.52 | ribosomal | citrulassin B | Streptomyces aurantiacus JA 4570
BGC0000575.5 |  | 0.51 | ribosomal | lariatin | Rhodococcus jostii
BGC0001889.2 |  | 0.50 | ribosomal | fusilassin | Thermobifida fusca YX

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lasso peptide predictions
Lists the possible core peptides for each biosynthetic enzyme. Each core peptide shows the leader and core peptide sequences.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.
Lassopeptides - No core peptides found.
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.78 out of 20.97
Confidence: strong
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.80 out of 26.33
Confidence: medium
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 28.04 out of 32.74
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.62 out of 24.78
Confidence: medium
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 21.46 out of 27.04
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.16 out of 26.06
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.91 out of 28.19
Confidence: medium
Additional weak hits (1):
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.37 out of 30.98
Confidence: weak
Lasso peptides
RREFinder
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of disulfide bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.
No core peptides found.
RRE predictions
RREfinder results sidepanel.

lassopeptide protocluster (995062...1019444)
PO880_RS04730
  RRE type: Stand_Alone_Lasso_RRE
  Location: 0 - 82
  Score: 75.1

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
CcpA | Catabolite control protein A
DasR | N-acetylglucosamine dependent repressor
FuR variant 2 | Ferric Uptake Regulator
LexA variant 2 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
ZuR variant 1 | Zinc-responsive repressor

NZ_CP116962.1 - Region 3 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,399,349 - 1,420,077 nt. (total: 20,729 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001291.3 |  | 0.41 | ribosomal | enterocin NKR-5-3B | Enterococcus faecium
BGC0001948.3 |  | 0.37 | other (other) | naseseazine C, C3-aryl pyrroloindolines | Streptomyces sp.
BGC0000046.4 |  | 0.35 | PKS | depudecin | Alternaria brassicicola
BGC0002227.3 |  | 0.31 | NRPS | AKML B, AKML D, AKML A, AKML C | Aspergillus luchuensis IFO 4308
BGC0002667.2 |  | 0.30 | ribosomal | estericin A | Clostridium estertheticum
BGC0001246.3 |  | 0.30 | PKS | trans-resorcylide | Sarocladium zeae
BGC0000688.4 |  | 0.29 | terpene | copalyl diphosphate | Diaporthe amygdali
BGC0001954.2 |  | 0.28 | NRPS, PKS | wortmanamide A, wortmanamide B | Talaromyces wortmannii
BGC0001366.5 |  | 0.27 | PKS | BE-24566B, zunyimycin A | Streptomyces sp. FJS31-2
BGC0002058.3 |  | 0.27 | NRPS, PKS | mutanocyclin | Streptococcus mutans B04Sm5

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001291.3 |  | 0.41 | ribosomal | enterocin NKR-5-3B | Enterococcus faecium
BGC0001948.3 |  | 0.37 | other (other) | naseseazine C, C3-aryl pyrroloindolines | Streptomyces sp.
BGC0000046.4 |  | 0.35 | PKS | depudecin | Alternaria brassicicola
BGC0002227.3 |  | 0.31 | NRPS | AKML B, AKML D, AKML A, AKML C | Aspergillus luchuensis IFO 4308
BGC0002667.2 |  | 0.30 | ribosomal | estericin A | Clostridium estertheticum
BGC0001246.3 |  | 0.30 | PKS | trans-resorcylide | Sarocladium zeae
BGC0000688.4 |  | 0.29 | terpene | copalyl diphosphate | Diaporthe amygdali
BGC0001954.2 |  | 0.28 | NRPS, PKS | wortmanamide A, wortmanamide B | Talaromyces wortmannii
BGC0001366.5 |  | 0.27 | PKS | BE-24566B, zunyimycin A | Streptomyces sp. FJS31-2
BGC0002058.3 |  | 0.27 | NRPS, PKS | mutanocyclin | Streptococcus mutans B04Sm5

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.50 out of 23.79
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.08 out of 23.79
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 28.99 out of 30.25
Confidence: strong
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.55 out of 19.26
Confidence: medium
Additional weak hits (1):
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 20.68 out of 29.72
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
ColR | Phenol-responsive regulator
IolR | Regulator of the inositol catabolism

NZ_CP116962.1 - Region 4 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,761,086 - 1,771,967 nt. (total: 10,882 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.

No matches found.

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.71 out of 29.72
Confidence: medium
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
NtrC | Nitrogen regulatory protein C
ToxT | Regulator of MSHA biosynthesis

NZ_CP116962.1 - Region 5 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,242,162 - 2,263,043 nt. (total: 20,882 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: peptidase
PO880_RS10970: methionine aminopeptidase

smcogs
  SMCOG1172: methionine aminopeptidase

Ligases: synthetase
PO880_RS10935: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002309.2 |  | 0.36 | terpene | cattleyene | Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000639.3 |  | 0.34 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.34 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0001605.3 |  | 0.32 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0001075.5 |  | 0.31 | PKS, terpene | aurachin RE | Rhodococcus erythropolis
BGC0001456.3 |  | 0.30 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000286.3 |  | 0.30 | PKS | viguiepinol | Streptomyces sp. KO-3988

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002309.2 |  | 0.36 | terpene | cattleyene | Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000639.3 |  | 0.34 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.34 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0001605.3 |  | 0.32 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0001075.5 |  | 0.31 | PKS, terpene | aurachin RE | Rhodococcus erythropolis
BGC0001456.3 |  | 0.30 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000286.3 |  | 0.30 | PKS | viguiepinol | Streptomyces sp. KO-3988

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
PO880_RS10935: PT_FPPS_like
Domain 1 (29 - 276): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  DMAPP, IPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.38 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.25 out of 27.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.87 out of 28.19
Confidence: medium
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ZuR variant 1 | Zinc-responsive repressor

NZ_CP116962.1 - Region 6 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,700,575 - 2,723,556 nt. (total: 22,982 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: protease
PO880_RS13015: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase
PO880_RS13025: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000504.5 |  | 0.99 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000500.5 |  | 0.53 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0001407.5 |  | 0.52 | ribosomal | bicereucin | Bacillus cereus SJ1
BGC0000523.3 |  | 0.51 | ribosomal | lactocin S | Lactobacillus sakei
BGC0000525.5 |  | 0.50 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000623.3 |  | 0.49 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000516.4 |  | 0.47 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0002698.2 |  | 0.47 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0002674.2 |  | 0.46 | ribosomal | enterocin F4-9 | Enterococcus faecalis
BGC0001210.5 |  | 0.45 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000504.5 |  | 0.99 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000500.5 |  | 0.53 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0001407.5 |  | 0.52 | ribosomal | bicereucin | Bacillus cereus SJ1
BGC0000523.3 |  | 0.51 | ribosomal | lactocin S | Lactobacillus sakei
BGC0000525.5 |  | 0.50 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000623.3 |  | 0.49 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000516.4 |  | 0.47 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0002698.2 |  | 0.47 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0002674.2 |  | 0.46 | ribosomal | enterocin F4-9 | Enterococcus faecalis
BGC0001210.5 |  | 0.45 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for PO880_RS13025

PO880_RS13030
Leader:
MLNKENQENYYSNKLELVGPSFEELSLEEMEAIQGS
Core:
G D V Q A E T T P A C F T I G L G V G A L F S A K F C
Core with dehydrations:
G D V Q A E Dhb Dhb P A Cys F Dhb I G L G V G A L F Dha A K F Cys

#### antiSMASH-DB 4.0 matches for PO880_RS13030

100.0%
NZ_AP026721.1 and 35 others:
NZ_CP015883.1 Lanthipeptides: A6B47_RS00875_lanthipeptide NZ_CP028286.1 Lanthipeptides: CEQ02_RS16115_lanthipeptide NZ_CP028721.1 Lanthipeptides: C7I32_RS15475_lanthipeptide NZ_CP028835.1 Lanthipeptides: C9432_RS02740_lanthipeptide NZ_CP028837.1 Lanthipeptides: C9432_RS15935_lanthipeptide NZ_CP033787.1 Lanthipeptides: EGX75_RS02740_lanthipeptide NZ_CP039296.1 Lanthipeptides: E7T02_RS02755_lanthipeptide NZ_CP045045.1 Lanthipeptides: F9293_RS12755_lanthipeptide NZ_CP075604.2 Lanthipeptides: KKP64_RS02155_lanthipeptide NZ_CP085289.1 Lanthipeptides: LIT95_RS07630_lanthipeptide NZ_CP085291.1 Lanthipeptides: LIT96_RS04335_lanthipeptide NZ_CP085297.1 Lanthipeptides: LIT97_RS14520_lanthipeptide NZ_CP086726.1 Lanthipeptides: LM507_RS03415_lanthipeptide NZ_CP091901.1 Lanthipeptides: L5I17_RS09010_lanthipeptide NZ_CP091905.1 Lanthipeptides: L5I20_RS14940_lanthipeptide NZ_CP091907.1 Lanthipeptides: L5I26_RS13265_lanthipeptide NZ_CP093957.1 Lanthipeptides: MPM64_RS01385_lanthipeptide NZ_CP116962.1 Lanthipeptides: PO880_RS13030_lanthipeptide NZ_JAASJP010000011.1 Lanthipeptides: HCH27_RS13275_lanthipeptide NZ_JAHZNN010000041.1 Lanthipeptides: K0X81_RS16410_lanthipeptide NZ_JAKTAU010000028.1 Lanthipeptides: MKK46_RS14535_lanthipeptide NZ_JALSCL010000035.1 Lanthipeptides: NEI30_RS13375_lanthipeptide NZ_JAQDOF010000024.1 Lanthipeptides: PGP79_RS14595_lanthipeptide NZ_JAQKZU010000014.1 Lanthipeptides: PMV60_RS12615_lanthipeptide NZ_KB932317.1 Lanthipeptides: Q95_RS09840_lanthipeptide NZ_KB932336.1 Lanthipeptides: Q9C_RS13350_lanthipeptide NZ_KB944697.1 Lanthipeptides: WO3_RS18030_lanthipeptide NZ_KB944708.1 Lanthipeptides: WO5_RS05650_lanthipeptide NZ_KB944753.1 Lanthipeptides: WO9_RS06460_lanthipeptide NZ_KB944762.1 Lanthipeptides: WOA_RS17470_lanthipeptide NZ_KB944819.1 Lanthipeptides: WOK_RS14355_lanthipeptide NZ_KB946767.1 Lanthipeptides: UK1_RS12990_lanthipeptide NZ_KB947483.1 Lanthipeptides: WUI_RS10440_lanthipeptide NZ_KZ845881.1 Lanthipeptides: EB41_RS04380_lanthipeptide NZ_NGMY01000001.1 Lanthipeptides: A5862_RS02370_lanthipeptide
Lanthipeptides: PO855_RS02215_lanthipeptide
1
G D V Q A E T T P A C F T I G L G V G A L F S A K F C
27
G D V Q A E T T P A C F T I G L G V G A L F S A K F C
1
G D V Q A E T T P A C F T I G L G V G A L F S A K F C
27
85.2%
NZ_CP011974.1 and 2 others:
NZ_CP115914.1 Lanthipeptides: PGN40_RS02040_lanthipeptide NZ_MWSI01000006.1 Lanthipeptides: B1B01_RS20140_lanthipeptide
Lanthipeptides: BEH_RS02100_lanthipeptide
1
G D V Q A E T T P A C F T I G L G V G A L F S A K F C
27
G D V Q A E T T P C F T I G L G V G A L S A C
1
G D V Q A E T T P V C F T I G L G V G A L V S A A G C
27
77.8%
NZ_JH791802.1 and 2 others:
NZ_MIFM01000001.1 Lanthipeptides: BHL22_RS00410_lanthipeptide NZ_NINI01000009.1 Lanthipeptides: CEV12_RS07260_lanthipeptide
Lanthipeptides: IKS_RS03655_lanthipeptide
1
G D V Q A E T T P A C F T I G L G V G A L F S A K F C
27
G D V Q A E T T P C F T+G L G V G+L S A C
1
G D V Q A E T T P V C F T V G L G V G S L V S A S V C
27
with 108 more sequence matches
Only the first 10 are displayed here.
74.1%
NZ_JH791802.1 and 2 others:
NZ_MIFM01000001.1 Lanthipeptides: BHL22_RS00405_lanthipeptide NZ_NINI01000009.1 Lanthipeptides: CEV12_RS07255_lanthipeptide
Lanthipeptides: IKS_RS03660_lanthipeptide
1
G D V Q A E T T P A C F T I G L G V G A L F S A K F C
27
G D V Q A E T T P C F T+G L G+G+L S A C
1
G D V Q A E T T P V C F T V G L G I G S L V S A S V C
27
71.4%
NZ_KB946334.1:
Lanthipeptides: UC7_RS10230_lanthipeptide
1
G D V Q A E T T P A C-F T I G L G V G A L F S A K F C
27
G D V Q E T T P C F T I G+G+G A L S K+C
1
G D V Q P E T T P I C G F T I G I G I G A L A S V K W C
28
71.4%
NZ_KB946334.1:
Lanthipeptides: UC7_RS10250_lanthipeptide
1
G D V Q A E T T P A C-F T I G L G V G A L F S A K F C
27
G D V Q E T T P C F T I G+G+G A L S K+C
1
G D V Q P E T T P L C G F T I G I G I G A L V S V K W C
28
70.0%
NZ_NVAW01000030.1 and 1 other:
NZ_NVEP01000021.1 Lanthipeptides: COL17_RS24445_lanthipeptide
Lanthipeptides: COK11_RS25885_lanthipeptide
1
G D V Q A E T T P A C---F T I G L G V G A L F S A K F C
27
G D V+ E T T P A C F T I G L G+G A L S A C
1
G D V K P E T T P A C L A G F T I G L G I G A L A S A A G C
30
66.7%
NZ_CP025701.1:
Lanthipeptides: C0569_RS26125_lanthipeptide
1
G D V Q A E T T P A C---F T I G L G V G A L F S A K F C
27
G D V+ E T T P A C F T+G L G+G A L S A C
1
G D V K P E T T P A C L A G F T V G L G I G A L A S A A G C
30
63.0%
NZ_JACDUU010000003.1:
Lanthipeptides: HNQ85_RS08035_lanthipeptide
1
G D V Q A E T T P A C F T I G L G V G A L F S A K F C
27
G D V Q E T+P A C T I G+G+G S F C
1
G D V Q P E T S P A C V T I G I G I G I G I S K L F C
27
59.3%
NZ_JAOVZP010000016.1 and 3 others:
NZ_NHVL01000036.1 Lanthipeptides: CEU70_RS27720_lanthipeptide NZ_NTYE01000081.1 Lanthipeptides: CN490_RS28165_lanthipeptide NZ_NVMN01000027.1 Lanthipeptides: CON30_RS23205_lanthipeptide
Lanthipeptides: OF830_RS26725_lanthipeptide
1
G D V Q A E T T P A C F T I G L G V G A L F S A K F C
27
D V Q E T T P A C T L G +F S K+C
1
S D V Q P E T T P A C V T-A L T T G I I F S I K W C
26
58.6%
NZ_JAOVZP010000016.1 and 3 others:
NZ_NHVL01000036.1 Lanthipeptides: CEU70_RS27725_lanthipeptide NZ_NTYE01000081.1 Lanthipeptides: CN490_RS28170_lanthipeptide NZ_NVMN01000027.1 Lanthipeptides: CON30_RS23200_lanthipeptide
Lanthipeptides: OF830_RS26730_lanthipeptide
1
G D V Q A E T T P A C---F T I G L G V G A L F S A K F C
27
D V Q E T T P A C F T I G V +F S + C
1
S D V Q P E T T P A C A V A F T I G A T V--I F S V R N C
28
57.1%
NZ_JANFNS010000003.1:
Lanthipeptides: NOM90_RS11325_lanthipeptide
2
D V Q A E T T P A C-F T I G L G V G A L F S A K F C
27
D V Q E T T P C F +G+G+G A+ S A C
2
D V Q P E T T P V C G F F V G V G I G A I I S A T A C
28
55.6%
NZ_JACSPU010000002.1:
Lanthipeptides: H9630_RS06775_lanthipeptide
1
G D V Q A E T T P A C F T I G L G V G A L F S A K F C
27
D V E T T P A C G L F S K F C
1
S D V A P E T T P A C-V A A F A T G L L F S I K F C
26

#### MIBiG 4.0 matches for PO880_RS13030

27.0%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
7
T T P A C F T I G L G V G A L-------F S A K F C
27
T P A + L G+ A+ S A F C
1
T D P A V T G L I L G I V A I Q A G V A V G V S A A F C
28
11.8%
BGC0000535.4 (ADJ56352.1):
Lanthipeptide: nisin A
8
T P A C F T
13
T P C T
8
T P G C K T
13
7.8%
BGC0002120.3 (NQE92413.1):
Lanthipeptide: nocathioamide A
9
P A C F T I G
15
P A C T+
38
P A C H T L S
44
PO880_RS13035
Leader:
MENLSVVPSFEELSVEEMEAIQGS
Core:
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
Core with dehydrations:
G D V Q A E Dhb Dhb P V Cys A V A A Dhb A A A Dha Dha A A Cys G W V G G G I F Dhb G V Dhb V V V Dha L K H Cys

#### antiSMASH-DB 4.0 matches for PO880_RS13035

100.0%
NZ_AP026721.1 and 34 others:
NZ_CP015883.1 Lanthipeptides: A6B47_RS00880_lanthipeptide NZ_CP028286.1 Lanthipeptides: CEQ02_RS16120_lanthipeptide NZ_CP028721.1 Lanthipeptides: C7I32_RS15480_lanthipeptide NZ_CP028835.1 Lanthipeptides: C9432_RS02735_lanthipeptide NZ_CP028837.1 Lanthipeptides: C9432_RS15930_lanthipeptide NZ_CP033787.1 Lanthipeptides: EGX75_RS02745_lanthipeptide NZ_CP039296.1 Lanthipeptides: E7T02_RS02750_lanthipeptide NZ_CP045045.1 Lanthipeptides: F9293_RS12760_lanthipeptide NZ_CP075604.2 Lanthipeptides: KKP64_RS02150_lanthipeptide NZ_CP085289.1 Lanthipeptides: LIT95_RS07625_lanthipeptide NZ_CP085291.1 Lanthipeptides: LIT96_RS04340_lanthipeptide NZ_CP085297.1 Lanthipeptides: LIT97_RS14515_lanthipeptide NZ_CP086726.1 Lanthipeptides: LM507_RS03420_lanthipeptide NZ_CP091901.1 Lanthipeptides: L5I17_RS09015_lanthipeptide NZ_CP091905.1 Lanthipeptides: L5I20_RS14935_lanthipeptide NZ_CP091907.1 Lanthipeptides: L5I26_RS13260_lanthipeptide NZ_CP093957.1 Lanthipeptides: MPM64_RS01390_lanthipeptide NZ_CP116962.1 Lanthipeptides: PO880_RS13035_lanthipeptide NZ_JAASJP010000011.1 Lanthipeptides: HCH27_RS13280_lanthipeptide NZ_JAHZNN010000041.1 Lanthipeptides: K0X81_RS16405_lanthipeptide NZ_JAKTAU010000028.1 Lanthipeptides: MKK46_RS14540_lanthipeptide NZ_JALSCL010000035.1 Lanthipeptides: NEI30_RS13380_lanthipeptide NZ_JAQDOF010000024.1 Lanthipeptides: PGP79_RS14600_lanthipeptide NZ_JAQKZU010000014.1 Lanthipeptides: PMV60_RS12620_lanthipeptide NZ_KB932317.1 Lanthipeptides: Q95_RS09835_lanthipeptide NZ_KB932336.1 Lanthipeptides: Q9C_RS13355_lanthipeptide NZ_KB944697.1 Lanthipeptides: WO3_RS18035_lanthipeptide NZ_KB944708.1 Lanthipeptides: WO5_RS05645_lanthipeptide NZ_KB944753.1 Lanthipeptides: WO9_RS06455_lanthipeptide NZ_KB944762.1 Lanthipeptides: WOA_RS17465_lanthipeptide NZ_KB944819.1 Lanthipeptides: WOK_RS14360_lanthipeptide NZ_KB946767.1 Lanthipeptides: UK1_RS12995_lanthipeptide NZ_KB947483.1 Lanthipeptides: WUI_RS10435_lanthipeptide NZ_KZ845881.1 Lanthipeptides: EB41_RS04385_lanthipeptide
Lanthipeptides: PO855_RS02210_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
93.2%
NZ_CP011974.1 and 2 others:
NZ_CP115914.1 Lanthipeptides: PGN40_RS02045_lanthipeptide NZ_MWSI01000006.1 Lanthipeptides: B1B01_RS20135_lanthipeptide
Lanthipeptides: BEH_RS02105_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q A E T T P V C A+A A T A A A S S A A C G+V G G G I F T G V T V V V S L K C
1
G D V Q A E T T P V C A I A A T A A A S S A A C G Y V G G G I F T G V T V V V S L K S C
44
90.9%
NZ_CP011974.1 and 2 others:
NZ_CP115914.1 Lanthipeptides: PGN40_RS02050_lanthipeptide NZ_MWSI01000006.1 Lanthipeptides: B1B01_RS20130_lanthipeptide
Lanthipeptides: BEH_RS02110_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q A E T T P V C A+A A T A A A S S A A C G+V G G G I F T G V T V V V+L K C
1
G D V Q A E T T P V C A I A A T A A A S S A A C G Y V G G G I F T G V T V V V T L K S C
44
with 107 more sequence matches
Only the first 10 are displayed here.
86.4%
NZ_JH791802.1 and 5 others:
NZ_MIFM01000001.1 Lanthipeptides: BHL22_RS00420_lanthipeptide NZ_MIFM01000001.1 Lanthipeptides: BHL22_RS00415_lanthipeptide NZ_NINI01000009.1 Lanthipeptides: CEV12_RS07275_lanthipeptide NZ_NINI01000009.1 Lanthipeptides: CEV12_RS07270_lanthipeptide NZ_NINI01000009.1 Lanthipeptides: CEV12_RS07265_lanthipeptide
Lanthipeptides: IKS_RS30065_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q A E T T P V C A+A A T A A S S A A C G W V G G G I T G V T V V++L K C
1
G D V Q A E T T P V C A I A A T T A A S S A A C G W V G G G I A T G V T V V I T L K S C
44
84.1%
NZ_CP025701.1:
Lanthipeptides: C0569_RS26130_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q A E T T P V C A+A A T A A A S S C G G G I T G V T V V V S L K H C
1
G D V Q A E T T P V C A I A A T A A A S S G I C A A T G G G I A T G V T V V V S L K H C
44
81.8%
NZ_NVAW01000030.1 and 1 other:
NZ_NVEP01000021.1 Lanthipeptides: COL17_RS24440_lanthipeptide
Lanthipeptides: COK11_RS25880_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q A E T T P V C A V A A T A A A S S C G G I T G V T V V V S L K C
1
G D V Q A E T T P V C A V A A T A A A S S G V C A A T G A G I A T G V T V V V S L K S C
44
77.3%
NZ_MIFM01000001.1 and 1 other:
NZ_NINI01000009.1 Lanthipeptides: CEV12_RS07280_lanthipeptide
Lanthipeptides: BHL22_RS00425_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q A E T T P V C A V+ S S A A C G W V G G I T G V T V V V+L K C
1
G D V Q A E T T P V C A V S V A T M T S S A A C G W V A G G I A T G V T V V V T L K S C
44
72.7%
NZ_CP062165.1 and 5 others:
NZ_CP062165.1 Lanthipeptides: JNUCC31_RS17165_lanthipeptide NZ_QICW01000005.1 Lanthipeptides: DEU73_RS14625_lanthipeptide NZ_QICW01000005.1 Lanthipeptides: DEU73_RS14625_lanthipeptide NZ_QLLI01000007.1 Lanthipeptides: DET54_RS17330_lanthipeptide NZ_QLLI01000007.1 Lanthipeptides: DET54_RS17330_lanthipeptide
Lanthipeptides: JNUCC31_RS17165_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q E T T P V C A V A A T A A S S A C V G G G I G V T+V+++K C
1
G D V Q P E T T P V C A V A A T V A A S S A T C A A V G G G I A V G V T I V L T I K S C
44
72.7%
NZ_JANFNS010000003.1:
Lanthipeptides: NOM90_RS11330_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
D V Q E T T P V C A V A A T A A S S A C V G G G+ G V T V V++L K C
1
A D V Q P E T T P V C A V A A T V A A S S A T C A A V G G G V A V G V T V V L T L K T C
44
70.5%
NZ_KB946334.1 and 1 other:
NZ_KB946334.1 Lanthipeptides: UC7_RS10235_lanthipeptide
Lanthipeptides: UC7_RS10245_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q A E T T P V C A++A T A A S S A A C V G G I T G+T+V++ K C
1
G D V Q A E T T P V C A I S A T V A A S S A A C A G V G A G I G T G I T I V L T F K R C
44
68.2%
NZ_KB946334.1:
Lanthipeptides: UC7_RS10240_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q E T T P V C A++A T A A S S A A C V G G I T G+T+V++ K C
1
G D V Q V E T T P V C A I S A T V A A S S A A C A G V G A G I G T G I T I V L T F K R C
44
68.2%
NZ_LN831278.1:
Lanthipeptides: BN1360_RS08835_lanthipeptide
2
D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
D V Q E T T P+C A V A A T A A S S A C V G G G I G V T+V+++K C
2
D V Q P E T T P I C A V A A T V A A S S A T C A A V G G G I A V G V T I V L T I K S C
44
65.9%
NC_014098.1:
Lanthipeptides: BTUS_RS14190_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q A E T T P+C A A T A S S A A C V G G I G V T+V+++K C
1
G D V Q A E T T P I C Y T A A T V T A S S A A C A G V G A G I V A G V T I V L T I K R C
44
PO880_RS13075
Leader:
MKEDKIHVLSLFISSIVLFLITIIFHEIAIG
Core:
L V I A L I C F P I S N S I A K K G S V A K F S K K S I L V
Core with dehydrations:
L V I A L I Cys F P I Dha N Dha I A K K G Dha V A K F Dha K K Dha I L V

#### antiSMASH-DB 4.0 matches for PO880_RS13075

100.0%
NZ_AP026721.1 and 9 others:
NZ_CP028835.1 Lanthipeptides: C9432_RS02690_lanthipeptide NZ_CP039296.1 Lanthipeptides: E7T02_RS02710_lanthipeptide NZ_CP045045.1 Lanthipeptides: F9293_RS12790_lanthipeptide NZ_CP085289.1 Lanthipeptides: LIT95_RS07585_lanthipeptide NZ_CP085291.1 Lanthipeptides: LIT96_RS04380_lanthipeptide NZ_CP086726.1 Lanthipeptides: LM507_RS03460_lanthipeptide NZ_CP093957.1 Lanthipeptides: MPM64_RS01420_lanthipeptide NZ_CP116962.1 Lanthipeptides: PO880_RS13075_lanthipeptide NZ_NGMY01000001.1 Lanthipeptides: A5862_RS02320_lanthipeptide
Lanthipeptides: PO855_RS02170_lanthipeptide
1
L V I A L I C F P I S N S I A K K G S V A K F S K K S I L V
30
L V I A L I C F P I S N S I A K K G S V A K F S K K S I L V
1
L V I A L I C F P I S N S I A K K G S V A K F S K K S I L V
30
9.7%
NZ_CP011152.1 and 1 other:
NZ_CP011152.1 Lanthipeptides: WR47_RS28810_lanthipeptide
Lanthipeptides: WR47_RS28810_lanthipeptide
10
I S N S I A K K G S V A K F S K K
26
I S N++ K G +K+
40
I S N T L G N K G H A C T I T K E
56
allorf_2717161_2717226
Leader:
MVTMLLQFLLYQPGA
Core:
S I I L C K
Core with dehydrations:
Dha I I L Cys K

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.29 out of 29.38
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26
Confidence: medium
Additional weak hits (4):
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 15.65 out of 18.46
Confidence: weak
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.88 out of 25.75
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 24.30 out of 35.63
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 16.36 out of 30.12
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

PO880_RS13030 - Class II
  Cleavage pHMM score: 2.00
  RODEO score: 0
  Monoisotopic mass: 2630.3 Da
  Molecular weight: 2632.0 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2650.0 Da N = 1
    2668.0 Da N = 2
PO880_RS13035 - Class II
  Cleavage pHMM score: 2.00
  RODEO score: 0
  Monoisotopic mass: 4017.0 Da
  Molecular weight: 4019.5 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4037.6 Da N = 1
    4055.6 Da N = 2
    4073.6 Da N = 3
    4091.6 Da N = 4
    4109.6 Da N = 5
PO880_RS13075 - Class II
  Cleavage pHMM score: -7.10
  RODEO score: 0
  Monoisotopic mass: 3083.9 Da
  Molecular weight: 3085.8 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3103.8 Da N = 1
    3121.9 Da N = 2
    3139.9 Da N = 3
    3157.9 Da N = 4
allorf_2717161_2717226 - Class II
  Cleavage pHMM score: -7.30
  RODEO score: 0
  Monoisotopic mass: 657.4 Da
  Molecular weight: 657.9 Da
  Number of bridges: 1

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
FuR variant 1 | Ferric Uptake Regulator