GCF_028335765.1 - 5 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP116604.1 (Streptococcus sp. HN38)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	RiPP-like	241,691	259,421
Region 1.2	lanthipeptide-class-iv	314,912	337,587
Region 1.3	terpene-precursor,T3PKS	537,033	578,198
Region 1.4	lanthipeptide-class-i	985,523	1,011,534	Medium	suicin 90-1330	ribosomal:RiPP
Region 1.5	RaS-RiPP	2,064,140	2,087,640	High	streptide	ribosomal:RiPP

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	RiPP-like	241,691	259,421
Region 1.2	lanthipeptide-class-iv	314,912	337,587
Region 1.3	terpene-precursor,T3PKS	537,033	578,198
Region 1.4	lanthipeptide-class-i	985,523	1,011,534	Medium	suicin 90-1330	ribosomal:RiPP
Region 1.5	RaS-RiPP	2,064,140	2,087,640	High	streptide	ribosomal:RiPP

No secondary metabolite regions were found in these records:: NZ_CP116605.1 (Streptococcus sp. HN38)

Compact view

NZ_CP116604.1 - Region 1 - RiPP-like

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Location: 241,691 - 259,421 nt. (total: 17,731 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000624.3	0.53	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0000619.3	0.52	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001602.3	0.52	ribosomal	gassericin-T	Lactobacillus gasseri
BGC0001388.3	0.52	ribosomal	gassericin E	Lactobacillus gasseri
BGC0000617.5	0.51	ribosomal	coagulin	Bacillus coagulans
BGC0002579.2	0.50	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0000558.5	0.49	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0000623.3	0.48	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0002577.2	0.48	ribosomal	lactococcin G	Lactococcus lactis
BGC0001862.4	0.45	ribosomal	pallidocin	Aeribacillus pallidus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000624.3	0.53	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0000619.3	0.52	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001602.3	0.52	ribosomal	gassericin-T	Lactobacillus gasseri
BGC0001388.3	0.52	ribosomal	gassericin E	Lactobacillus gasseri
BGC0000617.5	0.51	ribosomal	coagulin	Bacillus coagulans
BGC0002579.2	0.50	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0000558.5	0.49	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0000623.3	0.48	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0002577.2	0.48	ribosomal	lactococcin G	Lactococcus lactis
BGC0001862.4	0.45	ribosomal	pallidocin	Aeribacillus pallidus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.22 out of 27.78

Confidence: medium

Additional weak hits (1):

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.61 out of 20.01

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria

NZ_CP116604.1 - Region 2 - lanthipeptide-class-iv

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Location: 314,912 - 337,587 nt. (total: 22,676 nt) Show pHMM detection rules used

lanthipeptide-class-iv: (cds(LANC_like and Pkinase) and not micKC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

PHA78_RS01640: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000519.4	0.47	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0002700.2	0.45	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0000554.4	0.44	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001887.3	0.44	ribosomal	huazacin	Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0000553.3	0.43	ribosomal	SRO15-2212	Streptomyces filamentosus NRRL 15998
BGC0000558.5	0.43	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0001555.4	0.41	ribosomal	colicin V	Escherichia coli chi7122
BGC0002699.2	0.40	ribosomal	nostolysamide A, nostolysamide B	Nostoc punctiforme PCC 73102
BGC0001639.3	0.40	ribosomal	klebsidin	Klebsiella pneumoniae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000519.4	0.47	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0002700.2	0.45	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0000554.4	0.44	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001887.3	0.44	ribosomal	huazacin	Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0000553.3	0.43	ribosomal	SRO15-2212	Streptomyces filamentosus NRRL 15998
BGC0000558.5	0.43	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0001555.4	0.41	ribosomal	colicin V	Escherichia coli chi7122
BGC0002699.2	0.40	ribosomal	nostolysamide A, nostolysamide B	Nostoc punctiforme PCC 73102
BGC0001639.3	0.40	ribosomal	klebsidin	Klebsiella pneumoniae

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptides - No core peptides found.

Transcription Factor Binding Sites

Binding sites found:

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 25.99 out of 29.25

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.23 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.98 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.89 out of 27.78

Confidence: medium

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.68 out of 28.14

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.98 out of 20.97

Confidence: medium

Additional weak hits (5):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.63 out of 26.06

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 22.68 out of 28.14

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.38 out of 29.25

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.95 out of 31.73

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 19.98 out of 30.12

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

No core peptides found.

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
PerR	Peroxide regulator
SypG	Regulator of biofilm formation and host colonization
ToxT	Regulator of MSHA biosynthesis

NZ_CP116604.1 - Region 3 - T3PKS,terpene-precursor

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Location: 537,033 - 578,198 nt. (total: 41,166 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase reductase

PHA78_RS02785: hydroxymethylglutaryl-CoA reductase

smcogs: SMCOG1187: hydroxymethylglutaryl-CoA reductase

PHA78_RS02820: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

Transferases: acetyltransferase methyltransferase

PHA78_RS02710: isoprenylcysteine carboxyl methyltransferase

smcogs: SMCOG1150: isoprenylcysteine carboxyl methyltransferase

PHA78_RS02795: acetyl-CoA acetyltransferase

smcogs: SMCOG1124: acetyl-CoA acetyltransferase

Hydrolases: deacetylase

PHA78_RS02810: polysaccharide deacetylase

smcogs: SMCOG1235: polysaccharide deacetylase

Isomerases: mutase

PHA78_RS02800: phosphoglycerate mutase

smcogs: SMCOG1101: phosphoglycerate mutase

Ligases: synthase synthetase

PHA78_RS02730: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

PHA78_RS02790: hydroxymethylglutaryl-CoA synthase

smcogs: SMCOG1043: hydroxymethylglutaryl-CoA synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.36	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.33	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.26	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0001605.3	0.25	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0000550.3	0.24	ribosomal	salivaricin G32	Streptococcus salivarius
BGC0001456.3	0.23	terpene	isorenieratene	Streptomyces argillaceus
BGC0001529.5	0.22	other (other)	benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K	Streptomyces sp. RI18
BGC0000668.5	0.22	other (other), terpene	12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole	Hapalosiphon welwitschii UTEX B 1830
BGC0000633.3	0.22	terpene	carotenoid	Streptomyces avermitilis
BGC0001227.3	0.22	terpene	isorenieratene	Streptomyces collinus Tu 365

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.53	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.50	terpene	boleracene	Brassica oleracea var. oleracea
BGC0000866.5	0.48	other (other)	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0000867.3	0.46	other (other)	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0000205.3	0.44	PKS	bryostatin	Candidatus Endobugula sertula
BGC0002398.2	0.44	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0001605.3	0.43	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0002561.3	0.42	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0001529.5	0.41	other (other)	benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K	Streptomyces sp. RI18
BGC0000668.5	0.41	other (other), terpene	12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole	Hapalosiphon welwitschii UTEX B 1830

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

PHA78_RS02730: PT_FPPS_like

Domain 1 (25 - 272): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.64 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.40 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.70 out of 26.06

Confidence: medium

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis

NZ_CP116604.1 - Region 4 - lanthipeptide-class-i

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Location: 985,523 - 1,011,534 nt. (total: 26,012 nt) Show pHMM detection rules used

lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: protease

PHA78_RS04870: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase dehydratase

PHA78_RS04910: Lantibiotic dehydratase domain protein

smcogs: SMCOG1155: Lantibiotic dehydratase domain protein

PHA78_RS04920: Lanthionine synthetase C family protein

smcogs: SMCOG1140: Lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001789.3	0.75	ribosomal	suicin 90-1330	Streptococcus suis
BGC0000537.3	0.75	ribosomal	nisin U	Streptococcus uberis
BGC0000538.3	0.68	ribosomal	nisin Z	Lactococcus lactis
BGC0000535.4	0.68	ribosomal	nisin A	Lactococcus lactis subsp. lactis
BGC0000536.3	0.65	ribosomal	nisin Q	Lactococcus lactis
BGC0000506.4	0.57	ribosomal	entianin	Bacillus subtilis subsp. spizizenii
BGC0000541.5	0.57	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000542.3	0.57	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000559.4	0.55	ribosomal	subtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000556.5	0.54	ribosomal	streptin	Streptococcus pyogenes

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001789.3	0.75	ribosomal	suicin 90-1330	Streptococcus suis
BGC0000537.3	0.75	ribosomal	nisin U	Streptococcus uberis
BGC0000538.3	0.68	ribosomal	nisin Z	Lactococcus lactis
BGC0000535.4	0.68	ribosomal	nisin A	Lactococcus lactis subsp. lactis
BGC0000536.3	0.65	ribosomal	nisin Q	Lactococcus lactis
BGC0000506.4	0.57	ribosomal	entianin	Bacillus subtilis subsp. spizizenii
BGC0000541.5	0.57	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000542.3	0.57	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000559.4	0.55	ribosomal	subtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000556.5	0.54	ribosomal	streptin	Streptococcus pyogenes

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for PHA78_RS04910

PHA78_RS04905

Leader:

MQNNDFNLDLVSTSKEKKQGASPR

Core:

ITSISLCTAGCITGRIMGCHKTPTVSCNCH

Core with dehydrations:

IDhbDhaIDhaLCysDhbAGCysIDhbGRIMGCysHKDhbPDhbVDhaCysNCysH

antiSMASH-DB 4.0 matches for PHA78_RS04905

100.0%

NZ_CP116604.1and 2 others:

NZ_JAFFHI010000008.1 Lanthipeptides: JN541_RS08535_lanthipeptideNZ_JAFFHJ010000004.1 Lanthipeptides: JN542_RS06245_lanthipeptide

Lanthipeptides: PHA78_RS04905_lanthipeptide

ITSISLCTAGCITGRIMGCHKTPTVSCNCH

58.8%

NC_013656.1and 20 others:

NC_020450.1 Lanthipeptides: LILO_RS03015_lanthipeptideNZ_CP009472.1 Lanthipeptides: LG36_RS03420_lanthipeptideNZ_CP010050.1 Lanthipeptides: QI18_RS03300_lanthipeptideNZ_CP015903.1 Lanthipeptides: LLUC08_RS03255_lanthipeptideNZ_CP024954.1 Lanthipeptides: CV702_RS02990_lanthipeptideNZ_CP066300.1 Lanthipeptides: LacL0098_RS03205_lanthipeptideNZ_CP098790.1 Lanthipeptides: M5C73_RS03405_lanthipeptideNZ_JAALEQ010000006.1 Lanthipeptides: HFD15_RS10120_lanthipeptideNZ_JAJONJ010000005.1 Lanthipeptides: LSG16_RS07195_lanthipeptideNZ_JAQDWM010000007.1 Lanthipeptides: PGU01_RS08180_lanthipeptideNZ_JAQDXV010000018.1 Lanthipeptides: PGT80_RS11850_lanthipeptideNZ_JAQDYA010000007.1 Lanthipeptides: PGT72_RS09560_lanthipeptideNZ_JAQDYA010000007.1 Lanthipeptides: PGT72_RS09560_lanthipeptideNZ_JAQEIZ010000019.1 Lanthipeptides: PGX18_RS12025_lanthipeptideNZ_JAQEOU010000022.1 Lanthipeptides: PGV42_RS12330_lanthipeptideNZ_JAQEOV010000015.1 Lanthipeptides: PGW09_RS10765_lanthipeptideNZ_MTJP01000006.1 Lanthipeptides: BW151_RS03795_lanthipeptideNZ_MTJR01000005.1 Lanthipeptides: BW153_RS02980_lanthipeptideNZ_MTJS01000002.1 Lanthipeptides: BW154_RS09850_lanthipeptideNZ_RAGL01000022.1 Lanthipeptides: D6108_RS11395_lanthipeptide

Lanthipeptides: LLKF_RS13210_lanthipeptide

ITSISLCTAGCITGRIMGCH-KTPTVSCNCH

ITSISLCT GC TG +MGC+ KT T +C+ H

ITSISLCTPGCKTGALMGCNMKTATCNCSIH

58.8%

NZ_CP065984.1and 2 others:

NZ_CP095737.1 Lanthipeptides: MXM90_RS03205_lanthipeptideNZ_JAQDXJ010000021.1 Lanthipeptides: PGU19_RS11740_lanthipeptide

Lanthipeptides: I6I21_RS02785_lanthipeptide

ITSISLCTAGCITGRIMGCH-KTPTVSCNCH

ITSISLCT GC TG +MGC+ KT T C+ H

ITSISLCTPGCKTGALMGCNMKTATCHCSIH

with 87 more sequence matches

Only the first 10 are displayed here.

56.7%

NZ_CP024974.1and 1 other:

NZ_JAIMDQ010000006.1 Lanthipeptides: K6V44_RS04045_lanthipeptide

Lanthipeptides: CVO91_RS06555_lanthipeptide

ITSISLCTAGCITGRIMGCHKTPTVSCNCH

+TSISLCT GC TG +M C T +C CH

VTSISLCTPGCKTGILMTC-AIKTATCGCH

55.9%

NZ_CP009913.1and 1 other:

NZ_CP009913.1 Lanthipeptides: SSAL8618_RS00810_lanthipeptide

Lanthipeptides: SSAL8618_RS00815_lanthipeptide

ITSISLCTAGCITGRIMGCHKTPTVSCNCH

ITS SLCT GCITG +MGCH ++ CN H

ITSYSLCTPGCITGVLMGCH-IQSIGCNVH

55.9%

NZ_CP090412.1and 3 others:

NZ_QSTB01000004.1 Lanthipeptides: DXC22_RS03785_lanthipeptideNZ_VSTZ01000009.1 Lanthipeptides: FYK98_RS07445_lanthipeptideNZ_VSTZ01000009.1 Lanthipeptides: FYK98_RS07445_lanthipeptide

Lanthipeptides: LZF92_RS09890_lanthipeptide

ITSISLCTAGCITGRIMGCHKTPTVSCNCH

ITS SLCT GC TG +MGC T SC CH

ITSYSLCTPGCKTGALMGC-TMKTASCGCH

55.9%

NZ_FBTD01000003.1:

Lanthipeptides: PB1E_RS03075_lanthipeptide

ITSISLCTAGCITGRIMGCHKTPTVSCNCH

ITS+SLCT GC TG +MGC+ T SC CH

ITSVSLCTPGCKTGALMGCN-MKTASCGCH

55.9%

NZ_LR793265.1:

Lanthipeptides: HV392_RS09825_lanthipeptide

ITSISLCTAGCITGRIMGCHKTPTVSCNCH

ITS SLCT GCITGR+MGC + + CN H

ITSYSLCTPGCITGRLMGC-QFQSAGCNVH

54.3%

NZ_FNDP01000013.1:

Lanthipeptides: BLP54_RS11230_lanthipeptide

ITSISLCTAGCITGRIMGC-HKTPTVSCNCH

ITS SLCT GC+TG +MGC +KT T +C+ H

ITSKSLCTPGCVTGVLMGCNNKTATCNCSVH

53.3%

NZ_CP086149.1and 13 others:

NZ_CP086149.1 Lanthipeptides: LL127_RS22600_lanthipeptideNZ_CP086149.1 Lanthipeptides: LL127_RS22595_lanthipeptideNZ_CP086149.1 Lanthipeptides: LL127_RS22590_lanthipeptideNZ_CP086149.1 Lanthipeptides: LL127_RS22585_lanthipeptideNZ_CP086149.1 Lanthipeptides: LL127_RS22580_lanthipeptideNZ_CP086149.1 Lanthipeptides: LL127_RS22575_lanthipeptideNZ_CP086149.1 Lanthipeptides: LL127_RS22570_lanthipeptideNZ_CP087100.1 Lanthipeptides: LOR37_RS23225_lanthipeptideNZ_CP087100.1 Lanthipeptides: LOR37_RS23220_lanthipeptideNZ_CP087100.1 Lanthipeptides: LOR37_RS23215_lanthipeptideNZ_CP087100.1 Lanthipeptides: LOR37_RS23210_lanthipeptideNZ_CP087100.1 Lanthipeptides: LOR37_RS23205_lanthipeptideNZ_CP087100.1 Lanthipeptides: LOR37_RS23200_lanthipeptide

Lanthipeptides: LL127_RS22605_lanthipeptide

SLCTAGCITGRIMGCHK

SLCTAGCITGRIMGC+K

SLCTAGCITGRIMGCNK

53.1%

NZ_CP059471.1and 3 others:

NZ_FNZW01000001.1 Lanthipeptides: BMZ61_RS02110_lanthipeptideNZ_FOYC01000001.1 Lanthipeptides: BMZ88_RS03370_lanthipeptideNZ_KE384124.1 Lanthipeptides: G597_RS0106700_lanthipeptide

Lanthipeptides: H1R75_RS06635_lanthipeptide

ITSISLCTAGCITGRIMGCHKTPTVSCNCH

ITS SLCT GC TG +M C T +C CH

ITSKSLCTPGCKTGALMTC-PIKTATCGCH

53.1%

NZ_FNDP01000013.1:

Lanthipeptides: BLP54_RS11235_lanthipeptide

ITSISLCTAGCITGRIMGCHKTPTVS

SISLCT GC TG +MGCHK P+ S

FKSISLCTPGCPTGILMGCHKCPSGS

52.9%

NZ_JADNFO010000025.1:

Lanthipeptides: I2C89_RS09745_lanthipeptide

ITSISLCTAGCITGRIMGCHKTPTVSCNC

ITS SLCT GC TG +M CH T +CNC

ITSYSLCTPGCKTGVLMACH-LKTATCNC

MIBiG 4.0 matches for PHA78_RS04905

58.8%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

ITSISLCTAGCITGRIMGCH-KTPTVSCNCH

ITSISLCT GC TG +MGC+ KT T C+ H

ITSISLCTPGCKTGALMGCNMKTATCHCSIH

13.3%

BGC0002111.3 (EVG22_32245)and 1 other:

BGC0002111.3 (multiple genes) Lanthipeptide: andalusicin A or andalusicin B

Lanthipeptide: andalusicin A or andalusicin B

TVSCNC

T+S NC

TISNNC

10.8%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

ITGRIMG

+TG I+G

VTGLILG

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (3):

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 28.30 out of 36.54

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 20.26 out of 30.22

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 20.44 out of 30.22

Confidence: weak

Lanthipeptides

RREFinder

TFBS Finder

Core peptide predictions

PHA78_RS04905 - Class I

Cleavage pHMM score: 21.80

RODEO score: 27

Monoisotopic mass: 2962.4 Da

Molecular weight: 2964.5 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 2982.5 Da N = 1; 3000.6 Da N = 2; 3018.6 Da N = 3

RRE predictions

: RRE type: Lanthipeptide_LanB_RRE; Location: 143 - 229; Score: 67.0

TFBS definitions

Regulator	Description

NZ_CP116604.1 - Region 5 - RaS-RiPP

Download region GenBank file

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Location: 2,064,140 - 2,087,640 nt. (total: 23,501 nt) Show pHMM detection rules used

RaS-RiPP: (PF04055 and TIGR01716)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

PHA78_RS10035: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Ligases: synthase

PHA78_RS10045: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001209.3	0.83	ribosomal	streptide	Streptococcus thermophilus LMD-9
BGC0001535.3	0.55	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001929.2	0.45	ribosomal	WGK	Streptococcus ferus
BGC0002583.2	0.44	ribosomal	tryglysin B	Streptococcus mutans UA159
BGC0001736.3	0.34	NRPS	pepteridine A, pepteridine B	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002716.2	0.33	NRPS	gamexpeptide A, gamexpeptide B, gamexpeptide E, luminmide B, luminmide D, luminmide E, luminmide F, luminmide G	Photorhabdus laumondii subsp. laumondii
BGC0001567.4	0.32	NRPS	cysteoamide	Streptomyces lincolnensis
BGC0001594.3	0.32	other (other)	fischerindole L	Fischerella muscicola UTEX 1829
BGC0001628.4	0.31	NRPS	JBIR-78, JBIR-95	Kibdelosporangium sp. AK-AA56
BGC0001501.5	0.31	other (other)	ambiguine P	Fischerella sp. TAU

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001209.3	0.83	ribosomal	streptide	Streptococcus thermophilus LMD-9
BGC0001535.3	0.55	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001929.2	0.45	ribosomal	WGK	Streptococcus ferus
BGC0002583.2	0.44	ribosomal	tryglysin B	Streptococcus mutans UA159
BGC0001736.3	0.34	NRPS	pepteridine A, pepteridine B	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002716.2	0.33	NRPS	gamexpeptide A, gamexpeptide B, gamexpeptide E, luminmide B, luminmide D, luminmide E, luminmide F, luminmide G	Photorhabdus laumondii subsp. laumondii
BGC0001567.4	0.32	NRPS	cysteoamide	Streptomyces lincolnensis
BGC0001594.3	0.32	other (other)	fischerindole L	Fischerella muscicola UTEX 1829
BGC0001628.4	0.31	NRPS	JBIR-78, JBIR-95	Kibdelosporangium sp. AK-AA56
BGC0001501.5	0.31	other (other)	ambiguine P	Fischerella sp. TAU

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.60 out of 30.25

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26

Confidence: medium

Additional weak hits (2):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.45 out of 30.25

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 22.66 out of 26.12

Confidence: weak

RREFinder

TFBS Finder

RRE predictions

: RRE type: Streptide_RRE; Location: 1 - 80; Score: 77.2

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
ColR	Phenol-responsive regulator
ToxT	Regulator of MSHA biosynthesis