GCF_027683265.1 - 9 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_JAQCYD010000001.1 (Streptococcus mutans)

Region	Type	From	To
Region 1.1	RiPP-like	50,052	77,199
Region 1.2	RiPP-like	177,387	187,617
Region 1.3	terpene-precursor	321,802	342,671

NZ_JAQCYD010000002.1 (Streptococcus mutans)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 9.1	T3PKS	41,695	82,870

NZ_JAQCYD010000003.1 (Streptococcus mutans)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 10.1	RiPP-like	108,534	127,479
Region 10.2	lanthipeptide-class-ii	143,958	170,990	High	SmbA/SmbB	ribosomal:RiPP:Lanthipeptide

NZ_JAQCYD010000005.1 (Streptococcus mutans)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 12.1	RRE-containing,RaS-RiPP	1	12,887	High	tryglysin B	ribosomal:RiPP

NZ_JAQCYD010000007.1 (Streptococcus mutans)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 14.1	RiPP-like	40,433	50,838

NZ_JAQCYD010000008.1 (Streptococcus mutans)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 15.1	NRPS,NRPS-like	1	51,564

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	RiPP-like	50,052	77,199
Region 1.2	RiPP-like	177,387	187,617
Region 1.3	terpene-precursor	321,802	342,671
Region 9.1	T3PKS	41,695	82,870
Region 10.1	RiPP-like	108,534	127,479
Region 10.2	lanthipeptide-class-ii	143,958	170,990	High	SmbA/SmbB	ribosomal:RiPP:Lanthipeptide
Region 12.1	RRE-containing,RaS-RiPP	1	12,887	High	tryglysin B	ribosomal:RiPP
Region 14.1	RiPP-like	40,433	50,838
Region 15.1	NRPS,NRPS-like	1	51,564

No secondary metabolite regions were found in these records:: NZ_JAQCYD010000010.1 (Streptococcus mutans); NZ_JAQCYD010000011.1 (Streptococcus mutans); NZ_JAQCYD010000012.1 (Streptococcus mutans); NZ_JAQCYD010000013.1 (Streptococcus mutans); NZ_JAQCYD010000014.1 (Streptococcus mutans); NZ_JAQCYD010000015.1 (Streptococcus mutans); NZ_JAQCYD010000016.1 (Streptococcus mutans); NZ_JAQCYD010000004.1 (Streptococcus mutans); NZ_JAQCYD010000006.1 (Streptococcus mutans); NZ_JAQCYD010000009.1 (Streptococcus mutans)

Compact view

NZ_JAQCYD010000001.1 - Region 1 - RiPP-like

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Location: 50,052 - 77,199 nt. (total: 27,148 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

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MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: synthase

PGX70_RS00340: riboflavin biosynthesis protein RibD

smcogs: SMCOG1240: riboflavin biosynthesis protein RibD

Transferases: transketolase

PGX70_RS00275: transketolase

smcogs: SMCOG1204: transketolase

Hydrolases: synthase

PGX70_RS00340: riboflavin biosynthesis protein RibD

smcogs: SMCOG1240: riboflavin biosynthesis protein RibD

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000617.5	0.50	ribosomal	coagulin	Bacillus coagulans
BGC0000624.3	0.50	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0002579.2	0.48	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0000619.3	0.47	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001602.3	0.47	ribosomal	gassericin-T	Lactobacillus gasseri
BGC0001388.3	0.47	ribosomal	gassericin E	Lactobacillus gasseri
BGC0002577.2	0.44	ribosomal	lactococcin G	Lactococcus lactis
BGC0001229.4	0.43	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000558.5	0.42	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0001555.4	0.41	ribosomal	colicin V	Escherichia coli chi7122

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000617.5	0.50	ribosomal	coagulin	Bacillus coagulans
BGC0000624.3	0.50	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0002579.2	0.48	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0000619.3	0.47	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001602.3	0.47	ribosomal	gassericin-T	Lactobacillus gasseri
BGC0001388.3	0.47	ribosomal	gassericin E	Lactobacillus gasseri
BGC0002577.2	0.44	ribosomal	lactococcin G	Lactococcus lactis
BGC0001229.4	0.43	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000558.5	0.42	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0001555.4	0.41	ribosomal	colicin V	Escherichia coli chi7122

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.27 out of 26.06

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.54 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.69 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.34 out of 27.78

Confidence: medium

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.46 out of 29.25

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.32 out of 29.38

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.88 out of 26.06

Confidence: medium

Additional weak hits (3):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.25 out of 29.38

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 28.76 out of 39.62

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.99 out of 36.53

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1	Ferric Uptake Regulator
MogR	Repressor of flagellar motility genes
SypG	Regulator of biofilm formation and host colonization

NZ_JAQCYD010000001.1 - Region 2 - RiPP-like

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Location: 177,387 - 187,617 nt. (total: 10,231 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: back translocase hydrolase

PGX70_RS00915: GTP-binding protein LepA

smcogs: SMCOG1190: GTP-binding protein LepA

PGX70_RS00950: hydrolase

smcogs: SMCOG1179: hydrolase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002436.2	0.34	other (other)	coformycin	Streptomyces citricolor
BGC0002584.2	0.32	ribosomal	azolemycin B, azolemycin A, azolemycin D, azolemycin C	Streptomyces sp. FXJ1.264
BGC0001591.4	0.27	other (other)	fatty acid enol ester, N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0000259.3	0.26	PKS	prodigiosin	Serratia marcescens
BGC0000969.5	0.26	NRPS, PKS	chondramide A	Chondromyces crocatus
BGC0000207.5	0.23	PKS	chartreusin	Streptomyces chartreusis
BGC0002131.4	0.21	NRPS, PKS, saccharide	aurantoside A	Chloroflexi bacterium TSY
BGC0002435.3	0.20	other (other)	coformycin, aristeromycin	Micromonospora haikouensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002436.2	0.34	other (other)	coformycin	Streptomyces citricolor
BGC0002584.2	0.32	ribosomal	azolemycin B, azolemycin A, azolemycin D, azolemycin C	Streptomyces sp. FXJ1.264
BGC0001591.4	0.27	other (other)	fatty acid enol ester, N-tetradecanoyl tyrosine	uncultured bacterium CSLC2
BGC0000259.3	0.26	PKS	prodigiosin	Serratia marcescens
BGC0000969.5	0.26	NRPS, PKS	chondramide A	Chondromyces crocatus
BGC0000207.5	0.23	PKS	chartreusin	Streptomyces chartreusis
BGC0002131.4	0.21	NRPS, PKS, saccharide	aurantoside A	Chloroflexi bacterium TSY
BGC0002435.3	0.20	other (other)	coformycin, aristeromycin	Micromonospora haikouensis

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.66 out of 23.79

Confidence: medium

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.83 out of 21.55

Confidence: medium

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.87 out of 29.25

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.34 out of 26.06

Confidence: medium

Additional weak hits (3):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.54 out of 31.73

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 24.41 out of 30.97

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.29 out of 25.75

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
IolR	Regulator of the inositol catabolism
MogR	Repressor of flagellar motility genes
SypG	Regulator of biofilm formation and host colonization

NZ_JAQCYD010000001.1 - Region 3 - terpene-precursor

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Location: 321,802 - 342,671 nt. (total: 20,870 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: synthetase

PGX70_RS01665: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0001456.3	0.30	terpene	isorenieratene	Streptomyces argillaceus
BGC0000668.5	0.29	other (other), terpene	12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole	Hapalosiphon welwitschii UTEX B 1830
BGC0001756.3	0.28	terpene	retigeranin, arathanatriene	Arabidopsis thaliana
BGC0001605.3	0.28	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001594.3	0.27	other (other)	fischerindole L	Fischerella muscicola UTEX 1829
BGC0000648.3	0.27	terpene	carotenoid	Myxococcus xanthus
BGC0001126.4	0.26	other (other), terpene	12-epi-hapalindole J isonitrile, ambiguine A isonitrile, ambiguine B isonitrile, ambiguine C isonitrile, ambiguine D isonitrile, ambiguine E isonitrile, ambiguine K isonitrile, ambiguine L isonitrile, ambiguine I isonitrile, ambiguine J isonitrile	Fischerella ambigua UTEX 1903

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0001456.3	0.30	terpene	isorenieratene	Streptomyces argillaceus
BGC0000668.5	0.29	other (other), terpene	12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole	Hapalosiphon welwitschii UTEX B 1830
BGC0001756.3	0.28	terpene	retigeranin, arathanatriene	Arabidopsis thaliana
BGC0001605.3	0.28	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001594.3	0.27	other (other)	fischerindole L	Fischerella muscicola UTEX 1829
BGC0000648.3	0.27	terpene	carotenoid	Myxococcus xanthus
BGC0001126.4	0.26	other (other), terpene	12-epi-hapalindole J isonitrile, ambiguine A isonitrile, ambiguine B isonitrile, ambiguine C isonitrile, ambiguine D isonitrile, ambiguine E isonitrile, ambiguine K isonitrile, ambiguine L isonitrile, ambiguine I isonitrile, ambiguine J isonitrile	Fischerella ambigua UTEX 1903

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

PGX70_RS01665: PT_FPPS_like

Domain 1 (25 - 283): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: IPP, DMAPP → FPP

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.05 out of 20.97

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 15.51 out of 18.16

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.33 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.49 out of 29.38

Confidence: medium

Additional weak hits (2):

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.60 out of 30.97

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CcpA	Catabolite control protein A
FuR variant 1	Ferric Uptake Regulator
ToxT	Regulator of MSHA biosynthesis

NZ_JAQCYD010000002.1 - Region 1 - T3PKS

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Location: 41,695 - 82,870 nt. (total: 41,176 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase reductase

PGX70_RS03120: alkyl hydroperoxide reductase/ Thiol specific

smcogs: SMCOG1196: alkyl hydroperoxide reductase/ Thiol specific

PGX70_RS03205: hydroxymethylglutaryl-CoA reductase

smcogs: SMCOG1187: hydroxymethylglutaryl-CoA reductase

PGX70_RS03290: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Transferases: aminotransferase

PGX70_RS03255: aminotransferase

smcogs: SMCOG1019: aminotransferase

Ligases: synthase

PGX70_RS03210: hydroxymethylglutaryl-CoA synthase

smcogs: SMCOG1043: hydroxymethylglutaryl-CoA synthase

Translocases: permease

PGX70_RS03245: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000513.3	0.50	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000883.5	0.44	other (other)	arginomycin	Streptomyces arginensis
BGC0002561.3	0.44	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0000557.5	0.44	ribosomal	streptococcin A-FF22	Streptococcus pyogenes
BGC0001788.3	0.44	ribosomal	suicin 65	Streptococcus suis
BGC0000547.5	0.44	ribosomal	salivaricin 9	Streptococcus salivarius
BGC0000521.3	0.44	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0002294.3	0.44	other (other)	streptozotocin	Streptomyces achromogenes subsp. streptozoticus
BGC0000526.5	0.43	ribosomal	macedocin	Streptococcus macedonicus
BGC0000546.3	0.43	ribosomal	SAL-2242	Streptomyces albidoflavus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000513.3	0.50	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000883.5	0.44	other (other)	arginomycin	Streptomyces arginensis
BGC0002561.3	0.44	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0000557.5	0.44	ribosomal	streptococcin A-FF22	Streptococcus pyogenes
BGC0001788.3	0.44	ribosomal	suicin 65	Streptococcus suis
BGC0000547.5	0.44	ribosomal	salivaricin 9	Streptococcus salivarius
BGC0000521.3	0.44	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0002294.3	0.44	other (other)	streptozotocin	Streptomyces achromogenes subsp. streptozoticus
BGC0000526.5	0.43	ribosomal	macedocin	Streptococcus macedonicus
BGC0000546.3	0.43	ribosomal	SAL-2242	Streptomyces albidoflavus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.99 out of 27.55

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.13 out of 20.97

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.90 out of 26.06

Confidence: medium

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 25.31 out of 28.14

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.52 out of 28.19

Confidence: strong

Additional weak hits (7):

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.71 out of 25.75

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.96 out of 31.73

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.38 out of 29.25

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12

Confidence: weak

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 16.71 out of 20.47

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 26.34 out of 33.14

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.84 out of 27.04

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
GnfM	Regulator of nitrogen-fixation genes
MogR	Repressor of flagellar motility genes
PerR	Peroxide regulator
ZuR variant 1	Zinc-responsive repressor

NZ_JAQCYD010000003.1 - Region 1 - RiPP-like

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Location: 108,534 - 127,479 nt. (total: 18,946 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000624.3	0.41	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0002579.2	0.39	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0001291.3	0.34	ribosomal	enterocin NKR-5-3B	Enterococcus faecium
BGC0000540.5	0.33	ribosomal	paenibacillin	Paenibacillus polymyxa OSY-DF
BGC0000494.5	0.32	ribosomal	uberolysin	Streptococcus uberis
BGC0002667.2	0.24	ribosomal	estericin A	Clostridium estertheticum
BGC0000498.5	0.23	ribosomal	bovicin HJ50	Streptococcus equinus
BGC0000561.5	0.23	ribosomal	thermophilin 1277	Streptococcus thermophilus
BGC0000503.5	0.21	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0000164.5	0.20	PKS	tetronomycin	Streptomyces sp. NRRL 11266

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000624.3	0.41	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0002579.2	0.39	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0001291.3	0.34	ribosomal	enterocin NKR-5-3B	Enterococcus faecium
BGC0000540.5	0.33	ribosomal	paenibacillin	Paenibacillus polymyxa OSY-DF
BGC0000494.5	0.32	ribosomal	uberolysin	Streptococcus uberis
BGC0002667.2	0.24	ribosomal	estericin A	Clostridium estertheticum
BGC0000498.5	0.23	ribosomal	bovicin HJ50	Streptococcus equinus
BGC0000561.5	0.23	ribosomal	thermophilin 1277	Streptococcus thermophilus
BGC0000503.5	0.21	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0000164.5	0.20	PKS	tetronomycin	Streptomyces sp. NRRL 11266

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.35 out of 20.97

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 24.91 out of 29.25

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.99 out of 27.78

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.00 out of 24.78

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.05 out of 18.16

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.01 out of 26.06

Confidence: medium

Additional weak hits (1):

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 23.18 out of 30.11

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 2	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
SypG	Regulator of biofilm formation and host colonization
ToxT	Regulator of MSHA biosynthesis

NZ_JAQCYD010000003.1 - Region 2 - lanthipeptide-class-ii

Download region GenBank file

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Location: 143,958 - 170,990 nt. (total: 27,033 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: deacetylase

PGX70_RS05490: acetylornithine deacetylase

smcogs: SMCOG1247: acetylornithine deacetylase

Lyases: cyclase

PGX70_RS05530: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

PGX70_RS05545: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Ligases: synthase

PGX70_RS05585: pseudouridine synthase

smcogs: SMCOG1279: pseudouridine synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000552.3	0.99	ribosomal	SmbA, SmbB	Streptococcus mutans
BGC0000497.3	0.85	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0000626.3	0.54	ribosomal	thuricin	Bacillus thuringiensis
BGC0000623.3	0.53	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000525.5	0.53	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0001311.5	0.52	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0002698.2	0.52	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0001229.4	0.52	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000521.3	0.51	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000517.4	0.51	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000552.3	0.99	ribosomal	SmbA, SmbB	Streptococcus mutans
BGC0000497.3	0.85	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0000626.3	0.54	ribosomal	thuricin	Bacillus thuringiensis
BGC0000623.3	0.53	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000525.5	0.53	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0001311.5	0.52	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0002698.2	0.52	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0001229.4	0.52	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000521.3	0.51	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000517.4	0.51	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for PGX70_RS05530

PGX70_RS05515

Leader:

MKEIQKAGLQEELSILMDDANNLEQLTAG

Core:

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCSK

Core with dehydrations:

IGDhbDhbVVNDhaDhbFDhaIVLGNKGYICysDhbVDhbVECysMRNCysDhaK

antiSMASH-DB 4.0 matches for PGX70_RS05515

100.0%

NC_018089.1and 11 others:

NC_018089.1 Lanthipeptides: SMUGS5_RS08725_lanthipeptideNZ_CP044493.1 Lanthipeptides: FSA40_RS09065_lanthipeptideNZ_CP044493.1 Lanthipeptides: FSA40_RS09065_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS00325_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS00325_lanthipeptideNZ_JADPAN010000004.1 Lanthipeptides: I4U28_RS03985_lanthipeptideNZ_JADPAN010000004.1 Lanthipeptides: I4U28_RS03985_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS08120_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS08120_lanthipeptideNZ_JAQCYD010000003.1 Lanthipeptides: PGX70_RS05515_lanthipeptideNZ_JAQCYD010000003.1 Lanthipeptides: PGX70_RS05515_lanthipeptide

Lanthipeptides: SMUGS5_RS08725_lanthipeptide

1

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCSK

33

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCSK

1

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCSK

33

93.9%

NZ_CP043405.1and 1 other:

NZ_CP043405.1 Lanthipeptides: FY406_RS04355_lanthipeptide

Lanthipeptides: FY406_RS04355_lanthipeptide

1

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCS

32

IGTTVVNSTFSIVLGNKGYICTVTVECMRNC

1

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCQ

32

50.0%

NZ_BMVL01000013.1and 1 other:

NZ_BMVL01000013.1 Lanthipeptides: IE257_RS28650_lanthipeptide

Lanthipeptides: IE257_RS28650_lanthipeptide

1

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCSK

33

I TV + S LGN G++CTVTVEC +NC +

2

IFETVTYTVASWALGNNGHLCTVTVECQKNCQR

34

with 101 more sequence matches

Only the first 10 are displayed here.

48.6%

NZ_QKTG01000020.1and 1 other:

NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS16920_lanthipeptide

Lanthipeptides: DEI99_RS16920_lanthipeptide

1

IGTTVVNST---FSIVLGNKGYICTVTVECMRNC

31

IGTTV + S LGN G CT TVEC NC

3

IGTTVTTLSCYGVSWALGNDGNFCTATVECQSNC

36

48.5%

NZ_BMMP01000005.1and 3 others:

NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS28370_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptide

Lanthipeptides: IEY56_RS28370_lanthipeptide

8

STFSI--VLGNKGYICTVTVECMRNCS

32

+TFS+ VLGN G CT+TVEC NC+

4

NTFSLSDVLGNTGGWCTLTVECQPNCN

30

45.5%

NZ_CP016795.1and 5 others:

NZ_CP016795.1 Lanthipeptides: BC342_RS18360_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptide

Lanthipeptides: BC342_RS18360_lanthipeptide

8

STFSI--VLGNKGYICTVTVECMRNCS

32

+TFS+ LGN G CT+T EC NCS

4

NTFSLSDALGNHGGWCTLTKECQPNCS

30

45.5%

NZ_CP047419.1and 3 others:

NZ_CP047419.1 Lanthipeptides: GTU71_RS12805_lanthipeptideNZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15590_lanthipeptideNZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15590_lanthipeptide

Lanthipeptides: GTU71_RS12805_lanthipeptide

9

TFSIVLGNKGYICTVTVECMRNC

31

T S VLGN+G CT+TVEC NC

7

TLSNVLGNQGGWCTLTVECQPNC

29

45.5%

NZ_KV795763.1and 2 others:

NZ_KV804818.1 Lanthipeptides: allorf_114850_115005_lanthipeptideNZ_KV804818.1 Lanthipeptides: allorf_114850_115005_lanthipeptide

Lanthipeptides: allorf_248182_248337_lanthipeptide

4

TVVNSTFSIVLGNKGYICTVTVECMRNCS

32

T +S V+GN+G +CTVTVECM C

1

TAFPGWYSKVIGNRGRVCTVTVECMSVCQ

29

44.1%

NZ_BQXZ01000001.1and 1 other:

NZ_BQXZ01000001.1 Lanthipeptides: OCU69_RS05000_lanthipeptide

Lanthipeptides: OCU69_RS05000_lanthipeptide

9

TFSIVLGNKGYICTVTVECMRNCSK

33

T S+ +GNKG +CT T+EC NCSK

10

TLSVYMGNKGSVCTWTIECQSNCSK

34

42.4%

NC_002570.2and 3 others:

NC_002570.2 Lanthipeptides: AYT26_RS02480_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptide

Lanthipeptides: AYT26_RS02480_lanthipeptide

11

SIVLGNKGYICTVTVECMRNCS

32

S LGNKG CT+TVECM +C+

11

SCRLGNKGAYCTLTVECMPSCN

32

42.4%

NC_006322.1and 7 others:

NC_006322.1 Lanthipeptides: BLI_RS20295_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07805_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07805_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08835_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08835_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11865_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11865_lanthipeptide

Lanthipeptides: BLI_RS20295_lanthipeptide

10

FSIVLGNKGYICTVTVECMRNCS

32

S LGN GY+CTVT ECM +C+

10

LSKPLGNNGYLCTVTKECMPSCN

32

42.4%

NC_018499.1and 10 others:

NC_018499.1 Lanthipeptides: BCK_RS27855_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27850_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27860_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27855_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27850_lanthipeptideNZ_JAOPQW010000026.1 Lanthipeptides: OCD10_RS25275_lanthipeptideNZ_JAOPQW010000026.1 Lanthipeptides: OCD10_RS25270_lanthipeptideNZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27570_lanthipeptideNZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27565_lanthipeptideNZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27560_lanthipeptide

Lanthipeptides: BCK_RS27860_lanthipeptide

5

VVNSTFSIVLGNKGYICTVTVECMRNCS

32

V S LGNKG CT+T ECM +C+

5

VTPEGLSSWLGNKGGYCTLTKECMPSCN

32

42.4%

NZ_AKXV01000031.1and 4 others:

NZ_AKXV01000031.1 Lanthipeptides: Y19_RS0109895_lanthipeptideNZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13545_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide

Lanthipeptides: Y19_RS0109895_lanthipeptide

8

STFSI--VLGNKGYICTVTVECMRNCS

32

+TFS+ LGN+G CT+T EC NC+

4

NTFSLSDFLGNQGGWCTLTKECQPNCN

30

MIBiG 4.0 matches for PGX70_RS05515

42.4%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

11

SIVLGNKGYICTVTVECMRNCS

32

S LGNKG CT+TVECM +C+

7

SCRLGNKGAYCTLTVECMPSCN

28

42.4%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

8

STFSI--VLGNKGYICTVTVECMRNCS

32

+TFS+ LGN G CT+T EC NC+

4

NTFSLSNALGNNGGWCTLTKECQPNCN

30

15.4%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

21

CTVTVECMRNC

31

CT++ EC NC

28

CTLSKECQPNC

38

PGX70_RS05520

Leader:

MKSNLLKINNVTEMEKNMVTLIKDEDMELAGG

Core:

STPACAIGVVGITVAVTGISTACTSRCINK

Core with dehydrations:

DhaDhbPACysAIGVVGIDhbVAVDhbGIDhaDhbACysDhbDhaRCysINK

antiSMASH-DB 4.0 matches for PGX70_RS05520

100.0%

NC_018089.1and 13 others:

NC_018089.1 Lanthipeptides: SMUGS5_RS08730_lanthipeptideNZ_CP043405.1 Lanthipeptides: FY406_RS04350_lanthipeptideNZ_CP043405.1 Lanthipeptides: FY406_RS04350_lanthipeptideNZ_CP044493.1 Lanthipeptides: FSA40_RS09070_lanthipeptideNZ_CP044493.1 Lanthipeptides: FSA40_RS09070_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS00320_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS00320_lanthipeptideNZ_JADPAN010000004.1 Lanthipeptides: I4U28_RS03990_lanthipeptideNZ_JADPAN010000004.1 Lanthipeptides: I4U28_RS03990_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS08125_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS08125_lanthipeptideNZ_JAQCYD010000003.1 Lanthipeptides: PGX70_RS05520_lanthipeptideNZ_JAQCYD010000003.1 Lanthipeptides: PGX70_RS05520_lanthipeptide

Lanthipeptides: SMUGS5_RS08730_lanthipeptide

1

STPACAIGVVGITVAVTGISTACTSRCINK

30

STPACAIGVVGITVAVTGISTACTSRCINK

1

STPACAIGVVGITVAVTGISTACTSRCINK

30

43.3%

NZ_CP034414.1and 1 other:

NZ_CP034414.1 Lanthipeptides: EI692_RS18435_lanthipeptide

Lanthipeptides: EI692_RS18435_lanthipeptide

2

TPACAIGVVGITVAVTGISTACTSRC

27

TPA +I V G T STACT C

2

TPAISILVSGFISTNTCPSTACTRAC

27

40.6%

NZ_NUML01000015.1:

Lanthipeptides: COD66_RS20140_lanthipeptide

1

STPACAIGVVGITVAVTGISTACTSRC

27

+TPA VVGI+V + +T CTS+C

7

TTPATPTIVVGISVGLCP-TTKCTSKC

32

with 19 more sequence matches

Only the first 10 are displayed here.

40.0%

NZ_JAMXMK010000009.1:

Lanthipeptides: NGM22_RS28125_lanthipeptide

1

STPACAIGVVGITVAVTGISTACTSRC

27

STPACA VG+T+A G C

7

STPACA---VGVTIAAWGAHKLSYWNC

30

39.4%

NC_015215.1and 5 others:

NC_015215.1 Lanthipeptides: SGGBAA2069_RS00700_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09790_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09790_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05355_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05355_lanthipeptide

Lanthipeptides: SGGBAA2069_RS00700_lanthipeptide

1

STPACA---IGVVGITVAVTGISTACTSRCIN

29

STP CA + + A+ I+TACT+RC +

1

STPGCAWAAVSAISTVSALFQITTACTTRCYH

32

37.5%

NZ_CP036019.1and 1 other:

NZ_CP036019.1 Lanthipeptides: EXW52_RS27205_lanthipeptide

Lanthipeptides: EXW52_RS27205_lanthipeptide

1

STPACAIGVVGITVAVTGISTACTSRC

27

+TPA VV I+V + +T CTS+C

7

TTPATPTIVVAISVGLCP-TTKCTSKC

32

31.4%

NZ_CM000721.1and 9 others:

NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide

Lanthipeptides: BCERE0010_RS29355_lanthipeptide

9

VVGITVAVTG---ISTACTSRC

27

++G T+AVT +T CTSRC

14

IIGATIAVTASLCPTTKCTSRC

35

31.0%

NZ_NTSR01000029.1and 1 other:

NZ_NTSR01000029.1 Lanthipeptides: CN358_RS25165_lanthipeptide

Lanthipeptides: CN358_RS25165_lanthipeptide

5

CAIG--VVGITVAVTGIS------TACTSRC

27

CA+G VGIT+ S +AC+SRC

11

CAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

30.0%

NZ_CP084530.1and 1 other:

NZ_CP084530.1 Lanthipeptides: LDO05_RS02090_lanthipeptide

Lanthipeptides: LDO05_RS02090_lanthipeptide

9

VVGITVAVTGISTACTSRC

27

+ G+ A STACTS+C

10

ICGVASAAFCPSTACTSKC

28

26.7%

NC_014622.2and 5 others:

NC_017542.1 Lanthipeptides: PPM_RS22280_lanthipeptideNZ_CP029370.1 Lanthipeptides: DI243_RS20990_lanthipeptideNZ_CP034141.1 Lanthipeptides: EGM68_RS21685_lanthipeptideNZ_PNXP01000027.1 Lanthipeptides: C1I59_RS20700_lanthipeptideNZ_POVS01000032.1 Lanthipeptides: C1T21_RS26405_lanthipeptide

Lanthipeptides: PPSC2_RS50140_lanthipeptide

1

STPACAIGVVGITVAV

16

STP + V+G+TV V

7

STPTITVTVIGVTVLV

22

26.7%

NZ_CM000752.1and 15 others:

NZ_CM000752.1 Sactipeptides: BTHUR0007_RS37430_sactipeptideNZ_JABGBR020000007.1 Sactipeptides: HOV72_RS15955_sactipeptideNZ_JABGBR020000007.1 Sactipeptides: HOV72_RS15950_sactipeptideNZ_JYPH01000039.1 Sactipeptides: TU52_RS33370_sactipeptideNZ_JYPH01000039.1 Sactipeptides: TU52_RS33365_sactipeptideNZ_NJPZ01000025.1 Sactipeptides: CE087_RS29070_sactipeptideNZ_NJPZ01000025.1 Sactipeptides: CE087_RS29065_sactipeptideNZ_NJPZ01000025.1 Sactipeptides: CE087_RS29060_sactipeptideNZ_NUBO01000020.1 Sactipeptides: CN575_RS31360_sactipeptideNZ_NUBO01000020.1 Sactipeptides: CN575_RS31355_sactipeptideNZ_NUBO01000020.1 Sactipeptides: CN575_RS31350_sactipeptideNZ_NUUQ01000016.1 Sactipeptides: COI65_RS30820_sactipeptideNZ_NUUQ01000016.1 Sactipeptides: COI65_RS30815_sactipeptideNZ_NUUQ01000016.1 Sactipeptides: COI65_RS30810_sactipeptideNZ_NUXK01000018.1 Sactipeptides: COJ27_RS31850_sactipeptide

Sactipeptides: BTHUR0007_RS37435_sactipeptide

4

ACAIGVVGITVAVTGISTA

22

AC++ ++ + A TG STA

11

ACSVELLNLVTAATGASTA

29

26.7%

NZ_JAQQWR010000009.1:

Lanthipeptides: PQ473_RS20135_lanthipeptide

1

STPACAIGVVGITVAVTGIS

20

+TPAC G + IT+ V ++

7

TTPACIYGGIAITIGVVSVA

26

25.6%

NZ_CP009280.1and 1 other:

NZ_CP009280.1 Lanthipeptides: P40081_RS37160_lanthipeptide

Lanthipeptides: P40081_RS37160_lanthipeptide

5

CAIGVVGITVAVTGISTACTSRC

27

C IG V I+ + +T CTS+C

18

CVIGAVDISANLCP-TTKCTSKC

39

MIBiG 4.0 matches for PGX70_RS05520

16.7%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

20

STACTSRC

27

+T CTS+C

19

TTKCTSKC

26

16.2%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

20

STACTSRC

27

+T CTSRC

30

TTKCTSRC

37

Lanthipeptide(s) for PGX70_RS05545

PGX70_RS05515

Leader:

MKEIQKAGLQEELSILMDDANNLEQLTAG

Core:

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCSK

Core with dehydrations:

IGDhbDhbVVNDhaDhbFDhaIVLGNKGYICysDhbVDhbVECysMRNCysDhaK

antiSMASH-DB 4.0 matches for PGX70_RS05515

100.0%

NC_018089.1and 11 others:

NC_018089.1 Lanthipeptides: SMUGS5_RS08725_lanthipeptideNZ_CP044493.1 Lanthipeptides: FSA40_RS09065_lanthipeptideNZ_CP044493.1 Lanthipeptides: FSA40_RS09065_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS00325_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS00325_lanthipeptideNZ_JADPAN010000004.1 Lanthipeptides: I4U28_RS03985_lanthipeptideNZ_JADPAN010000004.1 Lanthipeptides: I4U28_RS03985_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS08120_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS08120_lanthipeptideNZ_JAQCYD010000003.1 Lanthipeptides: PGX70_RS05515_lanthipeptideNZ_JAQCYD010000003.1 Lanthipeptides: PGX70_RS05515_lanthipeptide

Lanthipeptides: SMUGS5_RS08725_lanthipeptide

1

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCSK

33

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCSK

1

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCSK

33

93.9%

NZ_CP043405.1and 1 other:

NZ_CP043405.1 Lanthipeptides: FY406_RS04355_lanthipeptide

Lanthipeptides: FY406_RS04355_lanthipeptide

1

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCS

32

IGTTVVNSTFSIVLGNKGYICTVTVECMRNC

1

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCQ

32

50.0%

NZ_BMVL01000013.1and 1 other:

NZ_BMVL01000013.1 Lanthipeptides: IE257_RS28650_lanthipeptide

Lanthipeptides: IE257_RS28650_lanthipeptide

1

IGTTVVNSTFSIVLGNKGYICTVTVECMRNCSK

33

I TV + S LGN G++CTVTVEC +NC +

2

IFETVTYTVASWALGNNGHLCTVTVECQKNCQR

34

with 101 more sequence matches

Only the first 10 are displayed here.

48.6%

NZ_QKTG01000020.1and 1 other:

NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS16920_lanthipeptide

Lanthipeptides: DEI99_RS16920_lanthipeptide

1

IGTTVVNST---FSIVLGNKGYICTVTVECMRNC

31

IGTTV + S LGN G CT TVEC NC

3

IGTTVTTLSCYGVSWALGNDGNFCTATVECQSNC

36

48.5%

NZ_BMMP01000005.1and 3 others:

NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS28370_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptide

Lanthipeptides: IEY56_RS28370_lanthipeptide

8

STFSI--VLGNKGYICTVTVECMRNCS

32

+TFS+ VLGN G CT+TVEC NC+

4

NTFSLSDVLGNTGGWCTLTVECQPNCN

30

45.5%

NZ_CP016795.1and 5 others:

NZ_CP016795.1 Lanthipeptides: BC342_RS18360_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptide

Lanthipeptides: BC342_RS18360_lanthipeptide

8

STFSI--VLGNKGYICTVTVECMRNCS

32

+TFS+ LGN G CT+T EC NCS

4

NTFSLSDALGNHGGWCTLTKECQPNCS

30

45.5%

NZ_CP047419.1and 3 others:

NZ_CP047419.1 Lanthipeptides: GTU71_RS12805_lanthipeptideNZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15590_lanthipeptideNZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15590_lanthipeptide

Lanthipeptides: GTU71_RS12805_lanthipeptide

9

TFSIVLGNKGYICTVTVECMRNC

31

T S VLGN+G CT+TVEC NC

7

TLSNVLGNQGGWCTLTVECQPNC

29

45.5%

NZ_KV795763.1and 2 others:

NZ_KV804818.1 Lanthipeptides: allorf_114850_115005_lanthipeptideNZ_KV804818.1 Lanthipeptides: allorf_114850_115005_lanthipeptide

Lanthipeptides: allorf_248182_248337_lanthipeptide

4

TVVNSTFSIVLGNKGYICTVTVECMRNCS

32

T +S V+GN+G +CTVTVECM C

1

TAFPGWYSKVIGNRGRVCTVTVECMSVCQ

29

44.1%

NZ_BQXZ01000001.1and 1 other:

NZ_BQXZ01000001.1 Lanthipeptides: OCU69_RS05000_lanthipeptide

Lanthipeptides: OCU69_RS05000_lanthipeptide

9

TFSIVLGNKGYICTVTVECMRNCSK

33

T S+ +GNKG +CT T+EC NCSK

10

TLSVYMGNKGSVCTWTIECQSNCSK

34

42.4%

NC_002570.2and 3 others:

NC_002570.2 Lanthipeptides: AYT26_RS02480_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptide

Lanthipeptides: AYT26_RS02480_lanthipeptide

11

SIVLGNKGYICTVTVECMRNCS

32

S LGNKG CT+TVECM +C+

11

SCRLGNKGAYCTLTVECMPSCN

32

42.4%

NC_006322.1and 7 others:

NC_006322.1 Lanthipeptides: BLI_RS20295_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07805_lanthipeptideNZ_CP033218.1 Lanthipeptides: D9Y32_RS07805_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08835_lanthipeptideNZ_LQYL01000021.1 Lanthipeptides: B4090_RS08835_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11865_lanthipeptideNZ_NIMP01000036.1 Lanthipeptides: CHCC14566_RS11865_lanthipeptide

Lanthipeptides: BLI_RS20295_lanthipeptide

10

FSIVLGNKGYICTVTVECMRNCS

32

S LGN GY+CTVT ECM +C+

10

LSKPLGNNGYLCTVTKECMPSCN

32

42.4%

NC_018499.1and 10 others:

NC_018499.1 Lanthipeptides: BCK_RS27855_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27850_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27860_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27855_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27850_lanthipeptideNZ_JAOPQW010000026.1 Lanthipeptides: OCD10_RS25275_lanthipeptideNZ_JAOPQW010000026.1 Lanthipeptides: OCD10_RS25270_lanthipeptideNZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27570_lanthipeptideNZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27565_lanthipeptideNZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27560_lanthipeptide

Lanthipeptides: BCK_RS27860_lanthipeptide

5

VVNSTFSIVLGNKGYICTVTVECMRNCS

32

V S LGNKG CT+T ECM +C+

5

VTPEGLSSWLGNKGGYCTLTKECMPSCN

32

42.4%

NZ_AKXV01000031.1and 4 others:

NZ_AKXV01000031.1 Lanthipeptides: Y19_RS0109895_lanthipeptideNZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13545_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide

Lanthipeptides: Y19_RS0109895_lanthipeptide

8

STFSI--VLGNKGYICTVTVECMRNCS

32

+TFS+ LGN+G CT+T EC NC+

4

NTFSLSDFLGNQGGWCTLTKECQPNCN

30

MIBiG 4.0 matches for PGX70_RS05515

42.4%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

11

SIVLGNKGYICTVTVECMRNCS

32

S LGNKG CT+TVECM +C+

7

SCRLGNKGAYCTLTVECMPSCN

28

42.4%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

8

STFSI--VLGNKGYICTVTVECMRNCS

32

+TFS+ LGN G CT+T EC NC+

4

NTFSLSNALGNNGGWCTLTKECQPNCN

30

15.4%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

21

CTVTVECMRNC

31

CT++ EC NC

28

CTLSKECQPNC

38

PGX70_RS05520

Leader:

MKSNLLKINNVTEMEKNMVTLIKDEDMELAGG

Core:

STPACAIGVVGITVAVTGISTACTSRCINK

Core with dehydrations:

DhaDhbPACysAIGVVGIDhbVAVDhbGIDhaDhbACysDhbDhaRCysINK

antiSMASH-DB 4.0 matches for PGX70_RS05520

100.0%

NC_018089.1and 13 others:

NC_018089.1 Lanthipeptides: SMUGS5_RS08730_lanthipeptideNZ_CP043405.1 Lanthipeptides: FY406_RS04350_lanthipeptideNZ_CP043405.1 Lanthipeptides: FY406_RS04350_lanthipeptideNZ_CP044493.1 Lanthipeptides: FSA40_RS09070_lanthipeptideNZ_CP044493.1 Lanthipeptides: FSA40_RS09070_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS00320_lanthipeptideNZ_CP050270.1 Lanthipeptides: HB753_RS00320_lanthipeptideNZ_JADPAN010000004.1 Lanthipeptides: I4U28_RS03990_lanthipeptideNZ_JADPAN010000004.1 Lanthipeptides: I4U28_RS03990_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS08125_lanthipeptideNZ_JALDUN010000005.1 Lanthipeptides: M1F82_RS08125_lanthipeptideNZ_JAQCYD010000003.1 Lanthipeptides: PGX70_RS05520_lanthipeptideNZ_JAQCYD010000003.1 Lanthipeptides: PGX70_RS05520_lanthipeptide

Lanthipeptides: SMUGS5_RS08730_lanthipeptide

1

STPACAIGVVGITVAVTGISTACTSRCINK

30

STPACAIGVVGITVAVTGISTACTSRCINK

1

STPACAIGVVGITVAVTGISTACTSRCINK

30

43.3%

NZ_CP034414.1and 1 other:

NZ_CP034414.1 Lanthipeptides: EI692_RS18435_lanthipeptide

Lanthipeptides: EI692_RS18435_lanthipeptide

2

TPACAIGVVGITVAVTGISTACTSRC

27

TPA +I V G T STACT C

2

TPAISILVSGFISTNTCPSTACTRAC

27

40.6%

NZ_NUML01000015.1:

Lanthipeptides: COD66_RS20140_lanthipeptide

1

STPACAIGVVGITVAVTGISTACTSRC

27

+TPA VVGI+V + +T CTS+C

7

TTPATPTIVVGISVGLCP-TTKCTSKC

32

with 19 more sequence matches

Only the first 10 are displayed here.

40.0%

NZ_JAMXMK010000009.1:

Lanthipeptides: NGM22_RS28125_lanthipeptide

1

STPACAIGVVGITVAVTGISTACTSRC

27

STPACA VG+T+A G C

7

STPACA---VGVTIAAWGAHKLSYWNC

30

39.4%

NC_015215.1and 5 others:

NC_015215.1 Lanthipeptides: SGGBAA2069_RS00700_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09790_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09790_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05355_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05355_lanthipeptide

Lanthipeptides: SGGBAA2069_RS00700_lanthipeptide

1

STPACA---IGVVGITVAVTGISTACTSRCIN

29

STP CA + + A+ I+TACT+RC +

1

STPGCAWAAVSAISTVSALFQITTACTTRCYH

32

37.5%

NZ_CP036019.1and 1 other:

NZ_CP036019.1 Lanthipeptides: EXW52_RS27205_lanthipeptide

Lanthipeptides: EXW52_RS27205_lanthipeptide

1

STPACAIGVVGITVAVTGISTACTSRC

27

+TPA VV I+V + +T CTS+C

7

TTPATPTIVVAISVGLCP-TTKCTSKC

32

31.4%

NZ_CM000721.1and 9 others:

NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide

Lanthipeptides: BCERE0010_RS29355_lanthipeptide

9

VVGITVAVTG---ISTACTSRC

27

++G T+AVT +T CTSRC

14

IIGATIAVTASLCPTTKCTSRC

35

31.0%

NZ_NTSR01000029.1and 1 other:

NZ_NTSR01000029.1 Lanthipeptides: CN358_RS25165_lanthipeptide

Lanthipeptides: CN358_RS25165_lanthipeptide

5

CAIG--VVGITVAVTGIS------TACTSRC

27

CA+G VGIT+ S +AC+SRC

11

CAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

30.0%

NZ_CP084530.1and 1 other:

NZ_CP084530.1 Lanthipeptides: LDO05_RS02090_lanthipeptide

Lanthipeptides: LDO05_RS02090_lanthipeptide

9

VVGITVAVTGISTACTSRC

27

+ G+ A STACTS+C

10

ICGVASAAFCPSTACTSKC

28

26.7%

NC_014622.2and 5 others:

NC_017542.1 Lanthipeptides: PPM_RS22280_lanthipeptideNZ_CP029370.1 Lanthipeptides: DI243_RS20990_lanthipeptideNZ_CP034141.1 Lanthipeptides: EGM68_RS21685_lanthipeptideNZ_PNXP01000027.1 Lanthipeptides: C1I59_RS20700_lanthipeptideNZ_POVS01000032.1 Lanthipeptides: C1T21_RS26405_lanthipeptide

Lanthipeptides: PPSC2_RS50140_lanthipeptide

1

STPACAIGVVGITVAV

16

STP + V+G+TV V

7

STPTITVTVIGVTVLV

22

26.7%

NZ_CM000752.1and 15 others:

NZ_CM000752.1 Sactipeptides: BTHUR0007_RS37430_sactipeptideNZ_JABGBR020000007.1 Sactipeptides: HOV72_RS15955_sactipeptideNZ_JABGBR020000007.1 Sactipeptides: HOV72_RS15950_sactipeptideNZ_JYPH01000039.1 Sactipeptides: TU52_RS33370_sactipeptideNZ_JYPH01000039.1 Sactipeptides: TU52_RS33365_sactipeptideNZ_NJPZ01000025.1 Sactipeptides: CE087_RS29070_sactipeptideNZ_NJPZ01000025.1 Sactipeptides: CE087_RS29065_sactipeptideNZ_NJPZ01000025.1 Sactipeptides: CE087_RS29060_sactipeptideNZ_NUBO01000020.1 Sactipeptides: CN575_RS31360_sactipeptideNZ_NUBO01000020.1 Sactipeptides: CN575_RS31355_sactipeptideNZ_NUBO01000020.1 Sactipeptides: CN575_RS31350_sactipeptideNZ_NUUQ01000016.1 Sactipeptides: COI65_RS30820_sactipeptideNZ_NUUQ01000016.1 Sactipeptides: COI65_RS30815_sactipeptideNZ_NUUQ01000016.1 Sactipeptides: COI65_RS30810_sactipeptideNZ_NUXK01000018.1 Sactipeptides: COJ27_RS31850_sactipeptide

Sactipeptides: BTHUR0007_RS37435_sactipeptide

4

ACAIGVVGITVAVTGISTA

22

AC++ ++ + A TG STA

11

ACSVELLNLVTAATGASTA

29

26.7%

NZ_JAQQWR010000009.1:

Lanthipeptides: PQ473_RS20135_lanthipeptide

1

STPACAIGVVGITVAVTGIS

20

+TPAC G + IT+ V ++

7

TTPACIYGGIAITIGVVSVA

26

25.6%

NZ_CP009280.1and 1 other:

NZ_CP009280.1 Lanthipeptides: P40081_RS37160_lanthipeptide

Lanthipeptides: P40081_RS37160_lanthipeptide

5

CAIGVVGITVAVTGISTACTSRC

27

C IG V I+ + +T CTS+C

18

CVIGAVDISANLCP-TTKCTSKC

39

MIBiG 4.0 matches for PGX70_RS05520

16.7%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

20

STACTSRC

27

+T CTS+C

19

TTKCTSKC

26

16.2%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

20

STACTSRC

27

+T CTSRC

30

TTKCTSRC

37

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.02 out of 20.97

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.93 out of 26.06

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.52 out of 27.55

Confidence: medium

Additional weak hits (1):

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.83 out of 32.74

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

PGX70_RS05515 - Class II

Cleavage pHMM score: -3.00

RODEO score: 0

Monoisotopic mass: 3392.7 Da

Molecular weight: 3395.0 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3413.0 Da N = 1; 3431.0 Da N = 2; 3449.0 Da N = 3; 3467.0 Da N = 4; 3485.1 Da N = 5

PGX70_RS05520 - Class II

Cleavage pHMM score: 2.60

RODEO score: 0

Monoisotopic mass: 2748.5 Da

Molecular weight: 2750.2 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2768.3 Da N = 1; 2786.3 Da N = 2; 2804.3 Da N = 3; 2822.3 Da N = 4; 2840.3 Da N = 5

PGX70_RS05515 - Class II

Cleavage pHMM score: -3.00

RODEO score: 0

Monoisotopic mass: 3392.7 Da

Molecular weight: 3395.0 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3413.0 Da N = 1; 3431.0 Da N = 2; 3449.0 Da N = 3; 3467.0 Da N = 4; 3485.1 Da N = 5

PGX70_RS05520 - Class II

Cleavage pHMM score: 2.60

RODEO score: 0

Monoisotopic mass: 2748.5 Da

Molecular weight: 2750.2 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2768.3 Da N = 1; 2786.3 Da N = 2; 2804.3 Da N = 3; 2822.3 Da N = 4; 2840.3 Da N = 5

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
GnfM	Regulator of nitrogen-fixation genes
MogR	Repressor of flagellar motility genes

NZ_JAQCYD010000005.1 - Region 1 - RRE-containing,RaS-RiPP

Download region GenBank file

Download region SVG

Location: 1 - 12,887 nt. (total: 12,887 nt) Show pHMM detection rules used

Region on contig edge.

RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])
RaS-RiPP: (PF04055 and TIGR01716)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002583.2	1.54	ribosomal	tryglysin B	Streptococcus mutans UA159
BGC0001929.2	0.96	ribosomal	WGK	Streptococcus ferus
BGC0001209.3	0.47	ribosomal	streptide	Streptococcus thermophilus LMD-9
BGC0001025.5	0.10	NRPS, PKS	myxovirescin A1	Myxococcus xanthus DK 1622

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002583.2	0.92	ribosomal	tryglysin B	Streptococcus mutans UA159
BGC0001929.2	0.77	ribosomal	WGK	Streptococcus ferus
BGC0001209.3	0.57	ribosomal	streptide	Streptococcus thermophilus LMD-9
BGC0001025.5	0.22	NRPS, PKS	myxovirescin A1	Myxococcus xanthus DK 1622

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.31 out of 18.46

Confidence: strong

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 26.23 out of 28.14

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.01 out of 28.19

Confidence: medium

Additional weak hits (3):

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.06 out of 26.85

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.01 out of 26.85

Confidence: weak

RREFinder

TFBS Finder

RRE predictions

: RRE type: Streptide_RRE; Location: 5 - 105; Score: 129.5; RRE type: Stand_Alone_Lasso_RRE; Location: 5 - 79; Score: 34.2
: RRE type: Streptide_RRE; Location: 5 - 105; Score: 129.5; RRE type: Stand_Alone_Lasso_RRE; Location: 5 - 79; Score: 34.2

TFBS definitions

Regulator	Description
PerR	Peroxide regulator
RpoN	Regulator of nitrogen assimilation and virulence
ZuR variant 1	Zinc-responsive repressor

NZ_JAQCYD010000007.1 - Region 1 - RiPP-like

Download region GenBank file

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Location: 40,433 - 50,838 nt. (total: 10,406 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

PGX70_RS08850: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000897.5	0.29	other (other)	dehydrophos	Streptomyces luridus
BGC0000938.5	0.27	other (aminocoumarin)	fosfomycin	Streptomyces fradiae
BGC0000807.3	0.26	saccharide	phosphonoglycans	Stackebrandtia nassauensis DSM 44728
BGC0001055.5	0.23	NRPS, PKS	yersiniabactin	Escherichia coli
BGC0000806.5	0.22	saccharide	phosphonoglycans	Glycomyces sp. NRRL B-16210
BGC0000654.4	0.20	saccharide, terpene	phenalinolactone A	Streptomyces sp. Tu6071

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000897.5	0.29	other (other)	dehydrophos	Streptomyces luridus
BGC0000938.5	0.27	other (aminocoumarin)	fosfomycin	Streptomyces fradiae
BGC0000807.3	0.26	saccharide	phosphonoglycans	Stackebrandtia nassauensis DSM 44728
BGC0001055.5	0.23	NRPS, PKS	yersiniabactin	Escherichia coli
BGC0000806.5	0.22	saccharide	phosphonoglycans	Glycomyces sp. NRRL B-16210
BGC0000654.4	0.20	saccharide, terpene	phenalinolactone A	Streptomyces sp. Tu6071

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.06 out of 19.26

Confidence: strong

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26

Confidence: medium

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.18 out of 25.88

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.18 out of 28.19

Confidence: medium

Additional weak hits (4):

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 22.61 out of 28.14

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 26.20 out of 39.62

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.05 out of 30.11

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.05 out of 30.11

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
PsrA	Oleic acid responsive regulator
ZuR variant 1	Zinc-responsive repressor

NZ_JAQCYD010000008.1 - Region 1 - NRPS,NRPS-like

Download region GenBank file

Download region SVG

Location: 1 - 51,564 nt. (total: 51,564 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

PGX70_RS09205: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: PPTase acylase

PGX70_RS09110: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

PGX70_RS09150: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

PGX70_RS09160: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: esterase hydrolase

PGX70_RS09100: thioesterase

smcogs: SMCOG1004: thioesterase

PGX70_RS09200: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

PGX70_RS09215: putative esterase

smcogs: SMCOG1104: putative esterase

Ligases: ligase synthase

PGX70_RS09105: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

PGX70_RS09115: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

PGX70_RS09120: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

PGX70_RS09125: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

PGX70_RS09130: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

PGX70_RS09135: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001825.4	0.74	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0002135.2	0.70	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000342.4	0.69	NRPS	enniatin	Fusarium equiseti
BGC0001833.4	0.69	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.4	0.68	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001133.4	0.68	NRPS	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0001166.5	0.67	NRPS	HC-toxin	Alternaria jesenskae
BGC0002286.3	0.66	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.66	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.65	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001825.4	0.71	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0002135.2	0.70	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001833.4	0.69	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.4	0.69	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001166.5	0.68	NRPS	HC-toxin	Alternaria jesenskae
BGC0001251.4	0.68	NRPS	epichloenin A	Epichloe festucae
BGC0001250.4	0.68	NRPS	epichloenin A	Epichloe festucae
BGC0001133.4	0.68	NRPS	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0001128.4	0.68	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.68	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.27 out of 26.06

Confidence: strong

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.88 out of 28.14

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.11 out of 23.79

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.67 out of 25.31

Confidence: medium

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 21.39 out of 27.04

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.51 out of 27.55

Confidence: medium

Additional weak hits (3):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 19.74 out of 30.22

Confidence: weak

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 19.96 out of 32.38

Confidence: weak

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 19.68 out of 29.51

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 51564:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (fatty_acid) + (mal - Leu) + (D-Ser - Pro) + (Val) + (Cys) + (Gly)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 25694:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (fatty_acid) + (mal - Leu) + (D-Ser - Pro) + (Val) + (Cys)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

PGX70_RS09105: fatty_acid

CAL_domain (150..448): fatty_acid

minowa: fatty_acid

Prediction, score:

fatty_acid: 52.0
NH2: 11.6
shikimic_acid: 0.0
Acetyl-CoA: 0.0
AHBA: 0.0

PGX70_RS09110: pk

PKS_AT (29..290): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 58.3%

minowa: Methoxymalonyl-CoA

Prediction, score:

Methoxymalonyl-CoA: 24.5
Malonyl-CoA: 18.8
inactive: 16.4
Methylmalonyl-CoA: 10.0
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PGX70_RS09120: Leu - Ser

Search NORINE for peptide: strict or relaxed

AMP-binding (203..587): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: LWHAFDASIWEPFLLTGAEYNNYGPTEYTVVATS
Nearest Stachelhaus code(s):: Leu DAWFLGNVVK (88% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1229..1628): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWMTFDVSIWEGHFFSSGEINLYGPTETAIEVTY
Nearest Stachelhaus code(s):: Ser DVWHFSLIEK (88% 8Å match)
Stachelhaus code match:: 100% (strong)

PGX70_RS09125: Pro

Search NORINE for peptide: strict or relaxed

AMP-binding (241..630): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: LFQAFDVASQESFLIVAGEYNHYGPSETHVVSID
Nearest Stachelhaus code(s):: Pro DVQFIAHVVK (79% 8Å match)
Stachelhaus code match:: 100% (strong)

PGX70_RS09130: Val - Cys

Search NORINE for peptide: strict or relaxed

AMP-binding (23..417): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: LDNSFDASTLEAFFIIGGDYNGYGPTENTVFTTM
Nearest Stachelhaus code(s):: Val DALFIGGTFK (71% 8Å match); Leu or Ile DALFIGGTFK (65% 8Å match)
Stachelhaus code match:: 90% (moderate)

AMP-binding (1059..1448): Cys

nrpys: Cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: TDISFDLSVYDGNSILSGDFSAGGATEGSIWSIY
Nearest Stachelhaus code(s):: Cys DLYNLSAIWK (82% 8Å match)
Stachelhaus code match:: 90% (moderate)

PGX70_RS09135: Gly

Search NORINE for peptide: strict or relaxed

AMP-binding (527..891): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FAITFDIFILEFQSLVGGEINLYGPTEATVWAFA
Nearest Stachelhaus code(s):: Gly DILQLGLVWK (76% 8Å match)
Stachelhaus code match:: 100% (strong)

PGX70_RS09150: pk

PKS_AT (7..290): pk

ATSignature: (unknown)

No matches above 50%

minowa: trans-1,2-CPDA

Prediction, score:

trans-1,2-CPDA: 0.0
inactive: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Methylmalonyl-CoA: 0.0
Methoxymalonyl-CoA: 0.0
Malonyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CatR	H2O2-responsive repressor
DasR	N-acetylglucosamine dependent repressor
GnfM	Regulator of nitrogen-fixation genes
IolR	Regulator of the inositol catabolism
MogR	Repressor of flagellar motility genes
PerR	Peroxide regulator