GCF_027672645.1 - 7 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_JAQDYA010000001.1 (Lactococcus lactis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	T3PKS,lanthipeptide-class-ii	1	39,422	Medium	carnolysin A1/carnolysin A2	ribosomal:RiPP:Lanthipeptide
Region 1.2	RaS-RiPP	407,877	431,094

NZ_JAQDYA010000010.1 (Lactococcus lactis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 2.1	terpene-precursor	20,480	41,337

NZ_JAQDYA010000012.1 (Lactococcus lactis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 4.1	RaS-RiPP	12,163	36,065

NZ_JAQDYA010000003.1 (Lactococcus lactis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 18.1	RiPP-like	1	11,081

NZ_JAQDYA010000007.1 (Lactococcus lactis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 22.1	lanthipeptide-class-i	1	25,090	High	nisin A	ribosomal:RiPP:Lanthipeptide
Region 22.2	betalactone	26,212	58,744

No secondary metabolite regions were found in these records:: NZ_JAQDYA010000011.1 (Lactococcus lactis); NZ_JAQDYA010000013.1 (Lactococcus lactis); NZ_JAQDYA010000014.1 (Lactococcus lactis); NZ_JAQDYA010000015.1 (Lactococcus lactis); NZ_JAQDYA010000016.1 (Lactococcus lactis); NZ_JAQDYA010000017.1 (Lactococcus lactis); NZ_JAQDYA010000018.1 (Lactococcus lactis); NZ_JAQDYA010000019.1 (Lactococcus lactis); NZ_JAQDYA010000002.1 (Lactococcus lactis); NZ_JAQDYA010000020.1 (Lactococcus lactis); NZ_JAQDYA010000021.1 (Lactococcus lactis); NZ_JAQDYA010000022.1 (Lactococcus lactis); NZ_JAQDYA010000023.1 (Lactococcus lactis); NZ_JAQDYA010000024.1 (Lactococcus lactis); NZ_JAQDYA010000004.1 (Lactococcus lactis); NZ_JAQDYA010000005.1 (Lactococcus lactis); NZ_JAQDYA010000006.1 (Lactococcus lactis); NZ_JAQDYA010000008.1 (Lactococcus lactis); NZ_JAQDYA010000009.1 (Lactococcus lactis)

Compact view

NZ_JAQDYA010000001.1 - Region 1 - T3PKS,lanthipeptide-class-ii

Download region GenBank file

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Location: 1 - 39,422 nt. (total: 39,422 nt) Show pHMM detection rules used

Region on contig edge.

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase reductase

PGT72_RS00070: hydroxymethylglutaryl-CoA reductase

smcogs: SMCOG1187: hydroxymethylglutaryl-CoA reductase

PGT72_RS00155: dehydrogenase

smcogs: SMCOG1181: dehydrogenase

Transferases: acetyltransferase

PGT72_RS00065: acetyl-CoA acetyltransferase

smcogs: SMCOG1124: acetyl-CoA acetyltransferase

Hydrolases: protease

PGT72_RS00035: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase

PGT72_RS00015: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Ligases: synthase

PGT72_RS00060: hydroxymethylglutaryl-CoA synthase

smcogs: SMCOG1043: hydroxymethylglutaryl-CoA synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.62	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000500.5	0.42	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0001210.5	0.40	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000502.5	0.38	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0000517.4	0.37	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0000554.4	0.37	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001407.5	0.36	ribosomal	bicereucin	Bacillus cereus SJ1
BGC0000525.5	0.36	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000516.4	0.35	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0002698.2	0.35	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.65	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001210.5	0.55	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000502.5	0.54	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0000500.5	0.53	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000516.4	0.53	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000517.4	0.53	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0000527.5	0.52	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0001407.5	0.51	ribosomal	bicereucin	Bacillus cereus SJ1
BGC0000866.5	0.51	other (other)	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0002698.2	0.50	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for PGT72_RS00015

PGT72_RS00020

Leader:

MKDTNINQNKVVGESFEDLSISEMMKIQGS

Core:

GDITPESTPVCAAFATLASGIALVKTIKGNC

Core with dehydrations:

GDIDhbPEDhaDhbPVCysAAFADhbLADhaGIALVKDhbIKGNCys

antiSMASH-DB 4.0 matches for PGT72_RS00020

100.0%

NZ_JAQDYA010000001.1:

Lanthipeptides: PGT72_RS00020_lanthipeptide

1

GDITPESTPVCAAFATLASGIALVKTIKGNC

31

GDITPESTPVCAAFATLASGIALVKTIKGNC

1

GDITPESTPVCAAFATLASGIALVKTIKGNC

31

74.2%

NZ_JQBU01000033.1and 1 other:

NZ_JQBV01000009.1 Lanthipeptides: IV76_RS12120_lanthipeptide

Lanthipeptides: IV75_RS14620_lanthipeptide

1

GDITPESTPVCAAFATLASGIALVKTIKGNC

31

GD+ PESTP+CA FATL S I LVKTIKG C

1

GDVMPESTPICAGFATLMSSIGLVKTIKGKC

31

67.7%

NZ_CP102973.1and 1 other:

NZ_FQQG01000014.1 Lanthipeptides: BT790_RS14420_lanthipeptide

Lanthipeptides: NW963_RS14100_lanthipeptide

1

GDITPESTPVCAAFATLASGIALVKTIKGNC

31

GD+TPEST VCAAFA+ A I LVKT+K C

1

GDVTPESTTVCAAFASFAGSIQLVKTLKSKC

31

with 103 more sequence matches

Only the first 10 are displayed here.

67.7%

NZ_JAFLVY010000007.1:

Lanthipeptides: JZO73_RS03920_lanthipeptide

1

GDITPESTPVCAAFATLASGIALVKTIKGNC

31

GD+ PES V + FATLAS IALVKT+KG+C

1

GDVNPES--VASFFATLASSIALVKTLKGHC

29

51.6%

NZ_FUXI01000002.1:

Lanthipeptides: B5D30_RS01205_lanthipeptide

1

GDITPESTPVCAAFATLASGIALVKTIKGNC

31

GD+ E+T VCA FAT I +V+TIK C

1

GDVNTETTTVCAVFATACGAIQVVRTIKKKC

31

48.4%

NZ_SDJV01000024.1:

Lanthipeptides: ES032_RS12700_lanthipeptide

1

GDITPESTPVCAAFATLASGIALVKTIKGNC

31

GD+ E+TP CA A++ +VKTIKG+C

1

GDVQVETTPACAFTASILVSYGVVKTIKGHC

31

45.2%

NZ_CP086395.1and 1 other:

NZ_JAKTAW010000012.1 Lanthipeptides: MKK30_RS11185_lanthipeptide

Lanthipeptides: LMK00_RS10670_lanthipeptide

1

GDITPESTPVCAAFATLASGIALVKTIKGNC

31

GD+ STP+C A + I +VKT+KG C

1

GDVEVRSTPICTFTAGVTVSIVIVKTLKGRC

31

45.0%

NZ_JAFHCX010000012.1and 1 other:

NZ_LR738722.1 Lanthipeptides: STREPSUIS_RS04075_lanthipeptide

Lanthipeptides: JXW96_RS06965_lanthipeptide

1

GDITPESTPVCA---------AFATLASGIALVKTIKGNC

31

GDI+PE+TP CA A + A + +VKT+KGNC

1

GDISPETTPACALIISKAISGAAVSFAFSVGVVKTVKGNC

40

44.4%

NZ_JADNGS010000002.1:

Lanthipeptides: I2D92_RS06840_lanthipeptide

1

GDITPESTPVCAAF-----ATLASGIALVKTIKGNC

31

GDI P S V +A AT + IA+ KT+KG C

1

GDIEPNSLTVASAVLMSAAATGSFSIAVTKTVKGKC

36

43.8%

NZ_JADMPO010000001.1:

Lanthipeptides: I2I27_RS01390_lanthipeptide

1

GDITPE-STPVCAAFATLASGIALVKTIKGNC

31

GD+ E +TP+CA T + I + KT+KG C

1

GDVEGEVTTPICAVAVTASLSIQVAKTLKGKC

32

41.9%

NZ_FNYB01000007.1and 2 others:

NZ_JAIPUK010000011.1 Lanthipeptides: K9P71_RS27180_lanthipeptideNZ_KB976303.1 Lanthipeptides: IGY_RS27695_lanthipeptide

Lanthipeptides: BMZ34_RS15960_lanthipeptide

1

GDITPESTPVCAAFATLASGIALVK

25

GD+ PE+TPVCA LA G ++ K

1

GDVQPETTPVCAIGGGLALGFSISK

25

41.9%

NZ_FTML01000041.1:

Lanthipeptides: BW937_RS20030_lanthipeptide

1

GDITPESTPVCAAFATLASGIALVKTI

27

GD+ PESTP C A + GIA+ K +

1

GDVQPESTPACVG-AGITVGIAISKLL

26

41.9%

NZ_JACDUU010000003.1:

Lanthipeptides: HNQ85_RS08040_lanthipeptide

1

GDITPESTPVCAAFATLASGIALVK

25

GD+ PE+T VCA ++ GIAL K

1

GDVQPETTTVCAIGGGISLGIALSK

25

PGT72_RS00025

Leader:

MEKLNINQIVGDTFEDLTISEMVQIQGS

Core:

GDITPETTPVCAATVASSAYCAGAASAVSGIVLSVFKC

Core with dehydrations:

GDIDhbPEDhbDhbPVCysAADhbVADhaDhaAYCysAGAADhaAVDhaGIVLDhaVFKCys

antiSMASH-DB 4.0 matches for PGT72_RS00025

100.0%

NZ_JAQDYA010000001.1:

Lanthipeptides: PGT72_RS00025_lanthipeptide

1

GDITPETTPVCAATVASSAYCAGAASAVSGIVLSVFKC

38

GDITPETTPVCAATVASSAYCAGAASAVSGIVLSVFKC

1

GDITPETTPVCAATVASSAYCAGAASAVSGIVLSVFKC

38

51.1%

NZ_JQBU01000033.1and 1 other:

NZ_JQBV01000009.1 Lanthipeptides: IV76_RS12140_lanthipeptide

Lanthipeptides: IV75_RS14640_lanthipeptide

1

GDITPE--TTPVCAATV-----ASSAYCAGAASAVSGIVLSVFKC

38

GDI E T+P C +V ASSA CA ASAVSG +LS +C

1

GDINGEFTTSPACVYSVMVVSKASSAKCAAGASAVSGAILSAIRC

45

51.0%

NZ_QICS01000003.1:

Lanthipeptides: C8E03_RS08695_lanthipeptide

1

GDITPE--TTPVC-----AATVASSAYC----AGAASAVSGIVLSVFKC

38

GD+ E T+P C AAT ASSA C AG AS VSG V S KC

1

GDVGAEFTTSPACVALSVAATQASSARCAIASAGVASLVSGAVHSALKC

49

with 119 more sequence matches

Only the first 10 are displayed here.

50.0%

NC_014098.1:

Lanthipeptides: BTUS_RS14190_lanthipeptide

1

GDITPETTPVC---AATVASSAYCAG-AASAVSG--IVLSVFKC

38

GD+ ETTP+C A ASSA CAG A V+G IVL++ +C

1

GDVQAETTPICYTAATVTASSAACAGVGAGIVAGVTIVLTIKRC

44

48.8%

NZ_JACWFH010000015.1:

Lanthipeptides: H0185_RS13725_lanthipeptide

1

GDITPETT-----PVCAATVASSAYCAGAASAVSGIVLSVFKC

38

GD+ ETT V V SS CA AA AV G+ LSV+KC

1

GDVQGETTTFPCFAVAYYGVQSSVSCAYAAGAVVGVGLSVWKC

43

47.5%

NZ_SDJV01000024.1:

Lanthipeptides: ES032_RS12705_lanthipeptide

1

GDITPETTPVCAATV-----ASSAYCAGAASAVSGIVLSVFKC

38

GD+ ETTP C +V SS +CAGA G V+S+ KC

1

GDVQVETTPACLYSVYVTANVSSVWCAGAT---VGAVISIVKC

40

47.4%

NZ_CP048887.1:

Lanthipeptides: BMG_RS29400_lanthipeptide

1

GDITPETTPVCAATVASSAYCAGAASAVSGIVLSVFKC

38

GD+ PETTPV V SSA C G V+G ++S+ C

1

GDVQPETTPV---AVTSSAVCIG----VTGAIISIKYC

31

45.5%

NZ_CP025701.1:

Lanthipeptides: C0569_RS26130_lanthipeptide

1

GDITPETTPVC---AATVASSAYCA----GAASAVSGIVLSVFKC

38

GD+ ETTPVC A ASS CA G A+ V+ +V+S+ C

1

GDVQAETTPVCAIAATAAASSGICAATGGGIATGVT-VVVSLKHC

44

45.5%

NZ_NVAW01000030.1and 1 other:

NZ_NVEP01000021.1 Lanthipeptides: COL17_RS24440_lanthipeptide

Lanthipeptides: COK11_RS25880_lanthipeptide

1

GDITPETTPVC---AATVASSAYC----AGAASAVSGIVLSVFKC

38

GD+ ETTPVC A ASS C AG A+ V+ +V+S+ C

1

GDVQAETTPVCAVAATAAASSGVCAATGAGIATGVT-VVVSLKSC

44

45.0%

NZ_JAQCQD010000003.1:

Lanthipeptides: PGZ38_RS05480_lanthipeptide

1

GDITPETTPVCAATVASSAYCAGAASAVSGIVLSVFK

37

GDI+PETTP CA + S +GAA + G +SV K

1

GDISPETTPACALII--SKIISGAAVSF-GFSVSVVK

34

44.9%

NZ_JADNGS010000002.1:

Lanthipeptides: I2D92_RS06835_lanthipeptide

1

GDITPE--TTPVC-----AATVASSAYCAGA----ASAVSGIVLSVFKC

38

GD++ E T+P C AA+ ASS C A AS VS VLS KC

1

GDVSGEFTTSPACVYVSVAASRASSQKCGQASGAIASFVSTAVLSAVKC

49

44.0%

NZ_JAQCQD010000003.1:

Lanthipeptides: PGZ38_RS05485_lanthipeptide

1

GDITPE---TTPVCAATV-----ASSAYCAGA----ASAVSGIVLSVFKC

38

GD++ E TTP C A++ ASS CA A +SA+SG V+S KC

1

GDMSAELTPTTPACFASIIYTARASSPNCAHALSVISSAISGAVISAVKC

50

42.5%

NZ_CP011152.1and 3 others:

NZ_CP011152.1 Lanthipeptides: WR47_RS28830_lanthipeptideNZ_CP011152.1 Lanthipeptides: WR47_RS28835_lanthipeptideNZ_CP011152.1 Lanthipeptides: WR47_RS28830_lanthipeptide

Lanthipeptides: WR47_RS28835_lanthipeptide

1

GDITPETTPVCAATVASSAYCAGAASAVSGIVLSVFKC

38

GD+TP+ TP TV A AG AV VL KC

1

GDVTPQATP----TVTILATAAGG--AVISAVLPTLKC

32

allorf_000137_000301

Leader:

MFNTNLNNCFKFNFSEGCKRSLPSVTLSVFLIFPLNYSRFYYTISTKMIFG

Core:

CVS

Core with dehydrations:

CysVDha

allorf_000494_000628

Leader:

MSNLVSAKFLDHCTAM

Core:

IYGEIERYFIGNKKVKLVDQAITCFKNQ

Core with dehydrations:

IYGEIERYFIGNKKVKLVDQAIDhbCysFKNQ

antiSMASH-DB 4.0 matches for allorf_000494_000628

100.0%

NZ_JAQDYA010000001.1:

Lanthipeptides: allorf_000494_000628_lanthipeptide

1

IYGEIERYFIGNKKVKLVDQAITCFKNQ

28

IYGEIERYFIGNKKVKLVDQAITCFKNQ

1

IYGEIERYFIGNKKVKLVDQAITCFKNQ

28

MIBiG 4.0 matches for allorf_000494_000628

21.4%

BGC0002322.3 (CEJ66604.1):

Lasso peptide: citrocin

3

GEIERYFIGN

12

G+I YFIG

4

GKIIEYFIGG

13

allorf_010404_010511

Leader:

MQLIAIIFM

Core:

MFHKSSSESCRTSNSHSKINYCLHRK

Core with dehydrations:

MFHKDhaDhaDhaEDhaCysRDhbDhaNDhaHDhaKINYCysLHRK

antiSMASH-DB 4.0 matches for allorf_010404_010511

100.0%

NZ_JAQDYA010000001.1:

Lanthipeptides: allorf_010404_010511_lanthipeptide

1

MFHKSSSESCRTSNSHSKINYCLHRK

26

MFHKSSSESCRTSNSHSKINYCLHRK

1

MFHKSSSESCRTSNSHSKINYCLHRK

26

30.8%

NZ_CP069611.1:

Lanthipeptides: allorf_29777_29872_lanthipeptide

11

RTSNSHSKINYCLHRK

26

R+SN +K YC+ RK

2

RSSNILTKSVYCVPRK

17

30.8%

NZ_KB903814.1:

Lanthipeptides: allorf_845501_845632_lanthipeptide

5

SSSESCRTSNSHSKINYCLHR

25

SSS + RT+ + C HR

6

SSSGASRTAARGPAVRPCCHR

26

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.21 out of 26.06

Confidence: strong

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 19.86 out of 21.84

Confidence: medium

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.74 out of 28.14

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.76 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.30 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.41 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.26 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.92 out of 27.78

Confidence: medium

Additional weak hits (6):

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.57 out of 25.75

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.42 out of 31.73

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.35 out of 36.54

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 23.28 out of 30.98

Confidence: weak

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 15.91 out of 20.47

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

Lanthipeptides

TFBS Finder

Core peptide predictions

PGT72_RS00020 - Class II

Cleavage pHMM score: 0.30

RODEO score: 0

Monoisotopic mass: 2939.6 Da

Molecular weight: 2941.4 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2959.4 Da N = 1; 2977.4 Da N = 2; 2995.5 Da N = 3; 3013.5 Da N = 4

PGT72_RS00025 - Class II

Cleavage pHMM score: 1.10

RODEO score: 0

Monoisotopic mass: 3454.7 Da

Molecular weight: 3456.9 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3474.9 Da N = 1; 3493.0 Da N = 2; 3511.0 Da N = 3; 3529.0 Da N = 4; 3547.0 Da N = 5; 3565.0 Da N = 6

allorf_000137_000301 - Class II

Cleavage pHMM score: -6.70

RODEO score: 0

Monoisotopic mass: 289.1 Da

Molecular weight: 289.3 Da

Number of bridges: 1

allorf_000494_000628 - Class II

Cleavage pHMM score: -6.90

RODEO score: 0

Monoisotopic mass: 3298.8 Da

Molecular weight: 3300.8 Da

Number of bridges: 1

allorf_010404_010511 - Class II

Cleavage pHMM score: -5.40

RODEO score: 0

Monoisotopic mass: 2922.4 Da

Molecular weight: 2924.3 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2942.3 Da N = 1; 2960.3 Da N = 2; 2978.3 Da N = 3; 2996.3 Da N = 4; 3014.4 Da N = 5; 3032.4 Da N = 6

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MexT	Global virulence regulator
MogR	Repressor of flagellar motility genes
PerR	Peroxide regulator

NZ_JAQDYA010000001.1 - Region 2 - RaS-RiPP

Download region GenBank file

Download region SVG

Location: 407,877 - 431,094 nt. (total: 23,218 nt) Show pHMM detection rules used

RaS-RiPP: (PF04055 and TIGR01716)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Translocases: transporter

PGT72_RS01850: sugar-binding lipoprotein

smcogs: SMCOG1143: sugar-binding lipoprotein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001209.3	0.46	ribosomal	streptide	Streptococcus thermophilus LMD-9
BGC0002322.3	0.41	ribosomal	citrocin	Citrobacter pasteurii
BGC0000616.4	0.40	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0002005.2	0.40	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0001639.3	0.40	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0002583.2	0.40	ribosomal	tryglysin B	Streptococcus mutans UA159
BGC0001929.2	0.39	ribosomal	WGK	Streptococcus ferus
BGC0000518.3	0.39	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0001391.3	0.39	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0002447.3	0.39	ribosomal	cerecyclin	Bacillus cereus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001209.3	0.46	ribosomal	streptide	Streptococcus thermophilus LMD-9
BGC0002322.3	0.41	ribosomal	citrocin	Citrobacter pasteurii
BGC0000616.4	0.40	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0002005.2	0.40	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0001639.3	0.40	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0002583.2	0.40	ribosomal	tryglysin B	Streptococcus mutans UA159
BGC0001929.2	0.39	ribosomal	WGK	Streptococcus ferus
BGC0000518.3	0.39	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0001391.3	0.39	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0002447.3	0.39	ribosomal	cerecyclin	Bacillus cereus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.06 out of 27.78

Confidence: medium

Additional weak hits (3):

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.77 out of 36.54

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.90 out of 28.14

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.72 out of 26.85

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria

NZ_JAQDYA010000010.1 - Region 1 - terpene-precursor

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Location: 20,480 - 41,337 nt. (total: 20,858 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: synthetase

PGT72_RS10970: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0001756.3	0.29	terpene	retigeranin, arathanatriene	Arabidopsis thaliana
BGC0001605.3	0.28	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001227.3	0.27	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000633.3	0.27	terpene	carotenoid	Streptomyces avermitilis
BGC0000648.3	0.27	terpene	carotenoid	Myxococcus xanthus
BGC0001529.5	0.27	other (other)	benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K	Streptomyces sp. RI18
BGC0001456.3	0.27	terpene	isorenieratene	Streptomyces argillaceus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0001756.3	0.29	terpene	retigeranin, arathanatriene	Arabidopsis thaliana
BGC0001605.3	0.28	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001227.3	0.27	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000633.3	0.27	terpene	carotenoid	Streptomyces avermitilis
BGC0000648.3	0.27	terpene	carotenoid	Myxococcus xanthus
BGC0001529.5	0.27	other (other)	benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K	Streptomyces sp. RI18
BGC0001456.3	0.27	terpene	isorenieratene	Streptomyces argillaceus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

PGT72_RS10970: PT_FPPS_like

Domain 1 (25 - 281): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.27 out of 26.06

Confidence: strong

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.74 out of 28.14

Confidence: medium

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 30.52 out of 30.97

Confidence: strong

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.82 out of 21.84

Confidence: medium

Additional weak hits (3):

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 23.05 out of 33.73

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 19.12 out of 30.11

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.48 out of 19.52

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CopR	Copper-responsive regulator
MexT	Global virulence regulator
MogR	Repressor of flagellar motility genes
PerR	Peroxide regulator

NZ_JAQDYA010000012.1 - Region 1 - RaS-RiPP

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Location: 12,163 - 36,065 nt. (total: 23,903 nt) Show pHMM detection rules used

RaS-RiPP: (PF04055 and TIGR01716)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

PGT72_RS11355: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001209.3	0.48	ribosomal	streptide	Streptococcus thermophilus LMD-9
BGC0001929.2	0.46	ribosomal	WGK	Streptococcus ferus
BGC0000779.3	0.38	saccharide	lipopolysaccharide	Aeromonas piscicola
BGC0002287.2	0.37	NRPS	mutanocyclin, leuvalin, tyrvalin	Streptococcus mutans
BGC0000938.5	0.37	other (aminocoumarin)	fosfomycin	Streptomyces fradiae
BGC0000806.5	0.29	saccharide	phosphonoglycans	Glycomyces sp. NRRL B-16210
BGC0001055.5	0.29	NRPS, PKS	yersiniabactin	Escherichia coli
BGC0000982.5	0.28	NRPS, PKS	cystothiazole A	Cystobacter fuscus
BGC0000780.3	0.24	saccharide	O&K-antigen	Vibrio parahaemolyticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001209.3	0.48	ribosomal	streptide	Streptococcus thermophilus LMD-9
BGC0001929.2	0.46	ribosomal	WGK	Streptococcus ferus
BGC0000779.3	0.38	saccharide	lipopolysaccharide	Aeromonas piscicola
BGC0002287.2	0.37	NRPS	mutanocyclin, leuvalin, tyrvalin	Streptococcus mutans
BGC0000938.5	0.37	other (aminocoumarin)	fosfomycin	Streptomyces fradiae
BGC0000806.5	0.29	saccharide	phosphonoglycans	Glycomyces sp. NRRL B-16210
BGC0001055.5	0.29	NRPS, PKS	yersiniabactin	Escherichia coli
BGC0000982.5	0.28	NRPS, PKS	cystothiazole A	Cystobacter fuscus
BGC0000780.3	0.24	saccharide	O&K-antigen	Vibrio parahaemolyticus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.21 out of 26.06

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.27 out of 26.06

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.23 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.11 out of 26.06

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.06 out of 19.26

Confidence: strong

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26

Confidence: medium

Additional weak hits (2):

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.19 out of 28.14

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.90 out of 32.74

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
MogR	Repressor of flagellar motility genes

NZ_JAQDYA010000003.1 - Region 1 - RiPP-like

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Location: 1 - 11,081 nt. (total: 11,081 nt) Show pHMM detection rules used

Region on contig edge.

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000617.5	0.50	ribosomal	coagulin	Bacillus coagulans
BGC0002579.2	0.48	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0000624.3	0.46	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0002577.2	0.44	ribosomal	lactococcin G	Lactococcus lactis
BGC0001388.3	0.44	ribosomal	gassericin E	Lactobacillus gasseri
BGC0000619.3	0.44	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001602.3	0.44	ribosomal	gassericin-T	Lactobacillus gasseri
BGC0001229.4	0.43	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000558.5	0.42	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0002005.2	0.40	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000617.5	0.50	ribosomal	coagulin	Bacillus coagulans
BGC0002579.2	0.48	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0000624.3	0.46	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0002577.2	0.44	ribosomal	lactococcin G	Lactococcus lactis
BGC0001388.3	0.44	ribosomal	gassericin E	Lactobacillus gasseri
BGC0000619.3	0.44	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001602.3	0.44	ribosomal	gassericin-T	Lactobacillus gasseri
BGC0001229.4	0.43	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000558.5	0.42	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0002005.2	0.40	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.72 out of 27.78

Confidence: medium

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.10 out of 32.93

Confidence: medium

Additional weak hits (3):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.93 out of 29.38

Confidence: weak

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 15.78 out of 18.46

Confidence: weak

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.65 out of 29.51

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 3	Repressor of DNA damage response

NZ_JAQDYA010000007.1 - Region 1 - lanthipeptide-class-i

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Location: 1 - 25,090 nt. (total: 25,090 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: protease

PGT72_RS09530: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase dehydratase

PGT72_RS09540: Lanthionine synthetase C family protein

smcogs: SMCOG1140: Lanthionine synthetase C family protein

PGT72_RS09555: Lantibiotic dehydratase domain protein

smcogs: SMCOG1155: Lantibiotic dehydratase domain protein

Ligases: synthase

PGT72_RS09590: polyprenol-monophosphomannose synthase ppm1

smcogs: SMCOG1123: polyprenol-monophosphomannose synthase ppm1

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000535.4	0.94	ribosomal	nisin A	Lactococcus lactis subsp. lactis
BGC0000538.3	0.88	ribosomal	nisin Z	Lactococcus lactis
BGC0000536.3	0.84	ribosomal	nisin Q	Lactococcus lactis
BGC0001789.3	0.74	ribosomal	suicin 90-1330	Streptococcus suis
BGC0000537.3	0.72	ribosomal	nisin U	Streptococcus uberis
BGC0000549.3	0.67	ribosomal	salivaricin D	Streptococcus salivarius
BGC0000542.3	0.60	ribosomal	paenicidin B	Paenibacillus terrae
BGC0002323.2	0.58	ribosomal	nisin J	Staphylococcus capitis
BGC0000541.5	0.57	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0001289.5	0.57	ribosomal	penisin	Paenibacillus ehimensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000535.4	0.94	ribosomal	nisin A	Lactococcus lactis subsp. lactis
BGC0000538.3	0.88	ribosomal	nisin Z	Lactococcus lactis
BGC0000536.3	0.84	ribosomal	nisin Q	Lactococcus lactis
BGC0001789.3	0.74	ribosomal	suicin 90-1330	Streptococcus suis
BGC0000537.3	0.72	ribosomal	nisin U	Streptococcus uberis
BGC0000549.3	0.67	ribosomal	salivaricin D	Streptococcus salivarius
BGC0000542.3	0.60	ribosomal	paenicidin B	Paenibacillus terrae
BGC0002323.2	0.58	ribosomal	nisin J	Staphylococcus capitis
BGC0000541.5	0.57	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0001289.5	0.57	ribosomal	penisin	Paenibacillus ehimensis

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for PGT72_RS09550

PGT72_RS09560

Leader:

MSTKDFNLDLVSVSKKDSGASPR

Core:

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSR

Core with dehydrations:

IDhbDhaIDhaLCysDhbPGCysKDhbGALMGCysNMKDhbADhbCysNCysDhaIHVDhaR

antiSMASH-DB 4.0 matches for PGT72_RS09560

100.0%

NZ_JAQDYA010000007.1and 1 other:

NZ_JAQDYA010000007.1 Lanthipeptides: PGT72_RS09560_lanthipeptide

Lanthipeptides: PGT72_RS09560_lanthipeptide

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSR

34

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSR

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSR

34

97.1%

NC_013656.1and 18 others:

NC_020450.1 Lanthipeptides: LILO_RS03015_lanthipeptideNZ_CP009472.1 Lanthipeptides: LG36_RS03420_lanthipeptideNZ_CP010050.1 Lanthipeptides: QI18_RS03300_lanthipeptideNZ_CP015903.1 Lanthipeptides: LLUC08_RS03255_lanthipeptideNZ_CP024954.1 Lanthipeptides: CV702_RS02990_lanthipeptideNZ_CP066300.1 Lanthipeptides: LacL0098_RS03205_lanthipeptideNZ_CP098790.1 Lanthipeptides: M5C73_RS03405_lanthipeptideNZ_JAALEQ010000006.1 Lanthipeptides: HFD15_RS10120_lanthipeptideNZ_JAJONJ010000005.1 Lanthipeptides: LSG16_RS07195_lanthipeptideNZ_JAQDWM010000007.1 Lanthipeptides: PGU01_RS08180_lanthipeptideNZ_JAQDXV010000018.1 Lanthipeptides: PGT80_RS11850_lanthipeptideNZ_JAQEIZ010000019.1 Lanthipeptides: PGX18_RS12025_lanthipeptideNZ_JAQEOU010000022.1 Lanthipeptides: PGV42_RS12330_lanthipeptideNZ_JAQEOV010000015.1 Lanthipeptides: PGW09_RS10765_lanthipeptideNZ_MTJP01000006.1 Lanthipeptides: BW151_RS03795_lanthipeptideNZ_MTJR01000005.1 Lanthipeptides: BW153_RS02980_lanthipeptideNZ_MTJS01000002.1 Lanthipeptides: BW154_RS09850_lanthipeptideNZ_RAGL01000022.1 Lanthipeptides: D6108_RS11395_lanthipeptide

Lanthipeptides: LLKF_RS13210_lanthipeptide

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSR

34

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVS+

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSK

34

94.1%

NZ_CP065984.1and 2 others:

NZ_CP095737.1 Lanthipeptides: MXM90_RS03205_lanthipeptideNZ_JAQDXJ010000021.1 Lanthipeptides: PGU19_RS11740_lanthipeptide

Lanthipeptides: I6I21_RS02785_lanthipeptide

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSR

34

ITSISLCTPGCKTGALMGCNMKTATC+CSIHVS+

1

ITSISLCTPGCKTGALMGCNMKTATCHCSIHVSK

34

with 123 more sequence matches

Only the first 10 are displayed here.

82.4%

NZ_FBTD01000003.1:

Lanthipeptides: PB1E_RS03075_lanthipeptide

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSR

34

ITS+SLCTPGCKTGALMGCNMKTA+C C +HVS+

1

ITSVSLCTPGCKTGALMGCNMKTASCGCHVHVSK

34

79.4%

NZ_JADNFO010000025.1:

Lanthipeptides: I2C89_RS09745_lanthipeptide

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSR

34

ITS SLCTPGCKTG LM C++KTATCNCSI VS+

1

ITSYSLCTPGCKTGVLMACHLKTATCNCSIIVSK

34

77.1%

NZ_FNDP01000013.1:

Lanthipeptides: BLP54_RS11230_lanthipeptide

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHV

32

ITS SLCTPGC TG LMGCN KTATCNCS+HV

3

ITSKSLCTPGCVTGVLMGCNNKTATCNCSVHV

34

76.5%

NZ_CP090412.1and 3 others:

NZ_QSTB01000004.1 Lanthipeptides: DXC22_RS03785_lanthipeptideNZ_VSTZ01000009.1 Lanthipeptides: FYK98_RS07445_lanthipeptideNZ_VSTZ01000009.1 Lanthipeptides: FYK98_RS07445_lanthipeptide

Lanthipeptides: LZF92_RS09890_lanthipeptide

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSR

34

ITS SLCTPGCKTGALMGC MKTA+C C +H+S+

1

ITSYSLCTPGCKTGALMGCTMKTASCGCHVHISK

34

68.6%

NZ_FNDP01000013.1and 1 other:

NZ_FNDP01000013.1 Lanthipeptides: BLP54_RS11225_lanthipeptide

Lanthipeptides: BLP54_RS11220_lanthipeptide

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHV

32

ITS SLCTPGC TG LMGC +ATCNCS+HV

3

ITSKSLCTPGCVTGLLMGCAGSSATCNCSVHV

34

67.6%

NC_022237.1and 1 other:

NZ_JUZI01000019.1 Lanthipeptides: ADI02_RS09325_lanthipeptide

Lanthipeptides: SII_RS05025_lanthipeptide

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSR

34

+TS+ +CTPGC TGALMGCN++TATCNC +H+S+

1

VTSVFMCTPGCVTGALMGCNLQTATCNCHVHISK

34

67.6%

NZ_CP059471.1and 3 others:

NZ_FNZW01000001.1 Lanthipeptides: BMZ61_RS02110_lanthipeptideNZ_FOYC01000001.1 Lanthipeptides: BMZ88_RS03370_lanthipeptideNZ_KE384124.1 Lanthipeptides: G597_RS0106700_lanthipeptide

Lanthipeptides: H1R75_RS06635_lanthipeptide

1

ITSISLCTPGCKTGALMGCNMKTATCNCSI

30

ITS SLCTPGCKTGALM C +KTATC C

1

ITSKSLCTPGCKTGALMTCPIKTATCGCHF

30

65.7%

NZ_CP013655.1and 2 others:

NZ_CP013655.1 Lanthipeptides: ATZ35_RS03635_lanthipeptideNZ_CP013655.1 Lanthipeptides: ATZ35_RS03630_lanthipeptide

Lanthipeptides: ATZ35_RS03640_lanthipeptide

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSR

34

ITS SLCTPGC TG LMGC +KT TCNCS+ + +

1

ITSKSLCTPGCVTGVLMGCALKTITCNCSVGIGK

34

64.7%

NZ_CP024974.1and 1 other:

NZ_JAIMDQ010000006.1 Lanthipeptides: K6V44_RS04045_lanthipeptide

Lanthipeptides: CVO91_RS06555_lanthipeptide

1

ITSISLCTPGCKTGALMGCNMKTATCNC

28

+TSISLCTPGCKTG LM C +KTATC C

1

VTSISLCTPGCKTGILMTCAIKTATCGC

28

64.7%

NZ_LR793265.1:

Lanthipeptides: HV392_RS09830_lanthipeptide

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSR

34

ITS SLCTPGC TG LMGC ++A CN +HVS+

1

ITSYSLCTPGCITGVLMGCQFQSAGCNVHVHVSK

34

MIBiG 4.0 matches for PGT72_RS09560

94.1%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSR

34

ITSISLCTPGCKTGALMGCNMKTATC+CSIHVS+

1

ITSISLCTPGCKTGALMGCNMKTATCHCSIHVSK

34

Lanthipeptide(s) for PGT72_RS09555

PGT72_RS09560

Leader:

MSTKDFNLDLVSVSKKDSGASPR

Core:

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSR

Core with dehydrations:

IDhbDhaIDhaLCysDhbPGCysKDhbGALMGCysNMKDhbADhbCysNCysDhaIHVDhaR

antiSMASH-DB 4.0 matches for PGT72_RS09560

100.0%

NZ_JAQDYA010000007.1and 1 other:

NZ_JAQDYA010000007.1 Lanthipeptides: PGT72_RS09560_lanthipeptide

Lanthipeptides: PGT72_RS09560_lanthipeptide

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSR

34

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSR

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSR

34

97.1%

NC_013656.1and 18 others:

NC_020450.1 Lanthipeptides: LILO_RS03015_lanthipeptideNZ_CP009472.1 Lanthipeptides: LG36_RS03420_lanthipeptideNZ_CP010050.1 Lanthipeptides: QI18_RS03300_lanthipeptideNZ_CP015903.1 Lanthipeptides: LLUC08_RS03255_lanthipeptideNZ_CP024954.1 Lanthipeptides: CV702_RS02990_lanthipeptideNZ_CP066300.1 Lanthipeptides: LacL0098_RS03205_lanthipeptideNZ_CP098790.1 Lanthipeptides: M5C73_RS03405_lanthipeptideNZ_JAALEQ010000006.1 Lanthipeptides: HFD15_RS10120_lanthipeptideNZ_JAJONJ010000005.1 Lanthipeptides: LSG16_RS07195_lanthipeptideNZ_JAQDWM010000007.1 Lanthipeptides: PGU01_RS08180_lanthipeptideNZ_JAQDXV010000018.1 Lanthipeptides: PGT80_RS11850_lanthipeptideNZ_JAQEIZ010000019.1 Lanthipeptides: PGX18_RS12025_lanthipeptideNZ_JAQEOU010000022.1 Lanthipeptides: PGV42_RS12330_lanthipeptideNZ_JAQEOV010000015.1 Lanthipeptides: PGW09_RS10765_lanthipeptideNZ_MTJP01000006.1 Lanthipeptides: BW151_RS03795_lanthipeptideNZ_MTJR01000005.1 Lanthipeptides: BW153_RS02980_lanthipeptideNZ_MTJS01000002.1 Lanthipeptides: BW154_RS09850_lanthipeptideNZ_RAGL01000022.1 Lanthipeptides: D6108_RS11395_lanthipeptide

Lanthipeptides: LLKF_RS13210_lanthipeptide

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSR

34

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVS+

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSK

34

94.1%

NZ_CP065984.1and 2 others:

NZ_CP095737.1 Lanthipeptides: MXM90_RS03205_lanthipeptideNZ_JAQDXJ010000021.1 Lanthipeptides: PGU19_RS11740_lanthipeptide

Lanthipeptides: I6I21_RS02785_lanthipeptide

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSR

34

ITSISLCTPGCKTGALMGCNMKTATC+CSIHVS+

1

ITSISLCTPGCKTGALMGCNMKTATCHCSIHVSK

34

with 123 more sequence matches

Only the first 10 are displayed here.

82.4%

NZ_FBTD01000003.1:

Lanthipeptides: PB1E_RS03075_lanthipeptide

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSR

34

ITS+SLCTPGCKTGALMGCNMKTA+C C +HVS+

1

ITSVSLCTPGCKTGALMGCNMKTASCGCHVHVSK

34

79.4%

NZ_JADNFO010000025.1:

Lanthipeptides: I2C89_RS09745_lanthipeptide

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSR

34

ITS SLCTPGCKTG LM C++KTATCNCSI VS+

1

ITSYSLCTPGCKTGVLMACHLKTATCNCSIIVSK

34

77.1%

NZ_FNDP01000013.1:

Lanthipeptides: BLP54_RS11230_lanthipeptide

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHV

32

ITS SLCTPGC TG LMGCN KTATCNCS+HV

3

ITSKSLCTPGCVTGVLMGCNNKTATCNCSVHV

34

76.5%

NZ_CP090412.1and 3 others:

NZ_QSTB01000004.1 Lanthipeptides: DXC22_RS03785_lanthipeptideNZ_VSTZ01000009.1 Lanthipeptides: FYK98_RS07445_lanthipeptideNZ_VSTZ01000009.1 Lanthipeptides: FYK98_RS07445_lanthipeptide

Lanthipeptides: LZF92_RS09890_lanthipeptide

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSR

34

ITS SLCTPGCKTGALMGC MKTA+C C +H+S+

1

ITSYSLCTPGCKTGALMGCTMKTASCGCHVHISK

34

68.6%

NZ_FNDP01000013.1and 1 other:

NZ_FNDP01000013.1 Lanthipeptides: BLP54_RS11225_lanthipeptide

Lanthipeptides: BLP54_RS11220_lanthipeptide

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHV

32

ITS SLCTPGC TG LMGC +ATCNCS+HV

3

ITSKSLCTPGCVTGLLMGCAGSSATCNCSVHV

34

67.6%

NC_022237.1and 1 other:

NZ_JUZI01000019.1 Lanthipeptides: ADI02_RS09325_lanthipeptide

Lanthipeptides: SII_RS05025_lanthipeptide

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSR

34

+TS+ +CTPGC TGALMGCN++TATCNC +H+S+

1

VTSVFMCTPGCVTGALMGCNLQTATCNCHVHISK

34

67.6%

NZ_CP059471.1and 3 others:

NZ_FNZW01000001.1 Lanthipeptides: BMZ61_RS02110_lanthipeptideNZ_FOYC01000001.1 Lanthipeptides: BMZ88_RS03370_lanthipeptideNZ_KE384124.1 Lanthipeptides: G597_RS0106700_lanthipeptide

Lanthipeptides: H1R75_RS06635_lanthipeptide

1

ITSISLCTPGCKTGALMGCNMKTATCNCSI

30

ITS SLCTPGCKTGALM C +KTATC C

1

ITSKSLCTPGCKTGALMTCPIKTATCGCHF

30

65.7%

NZ_CP013655.1and 2 others:

NZ_CP013655.1 Lanthipeptides: ATZ35_RS03635_lanthipeptideNZ_CP013655.1 Lanthipeptides: ATZ35_RS03630_lanthipeptide

Lanthipeptides: ATZ35_RS03640_lanthipeptide

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSR

34

ITS SLCTPGC TG LMGC +KT TCNCS+ + +

1

ITSKSLCTPGCVTGVLMGCALKTITCNCSVGIGK

34

64.7%

NZ_CP024974.1and 1 other:

NZ_JAIMDQ010000006.1 Lanthipeptides: K6V44_RS04045_lanthipeptide

Lanthipeptides: CVO91_RS06555_lanthipeptide

1

ITSISLCTPGCKTGALMGCNMKTATCNC

28

+TSISLCTPGCKTG LM C +KTATC C

1

VTSISLCTPGCKTGILMTCAIKTATCGC

28

64.7%

NZ_LR793265.1:

Lanthipeptides: HV392_RS09830_lanthipeptide

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSR

34

ITS SLCTPGC TG LMGC ++A CN +HVS+

1

ITSYSLCTPGCITGVLMGCQFQSAGCNVHVHVSK

34

MIBiG 4.0 matches for PGT72_RS09560

94.1%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

1

ITSISLCTPGCKTGALMGCNMKTATCNCSIHVSR

34

ITSISLCTPGCKTGALMGCNMKTATC+CSIHVS+

1

ITSISLCTPGCKTGALMGCNMKTATCHCSIHVSK

34

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 16.78 out of 18.16

Confidence: strong

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.61 out of 25.88

Confidence: medium

Additional weak hits (3):

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 19.70 out of 29.51

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 24.64 out of 35.63

Confidence: weak

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 20.28 out of 29.72

Confidence: weak

Lanthipeptides

RREFinder

TFBS Finder

Core peptide predictions

PGT72_RS09560 - Class I

Cleavage pHMM score: 26.70

RODEO score: 27

Monoisotopic mass: 3338.6 Da

Molecular weight: 3341.0 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 3359.0 Da N = 1; 3377.0 Da N = 2; 3395.0 Da N = 3; 3413.1 Da N = 4

PGT72_RS09560 - Class I

Cleavage pHMM score: 26.70

RODEO score: 27

Monoisotopic mass: 3338.6 Da

Molecular weight: 3341.0 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 3359.0 Da N = 1; 3377.0 Da N = 2; 3395.0 Da N = 3; 3413.1 Da N = 4

RRE predictions

: RRE type: Lanthipeptide_LanB_RRE; Location: 141 - 229; Score: 29.4

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CRP	Cyclic AMP receptor protein
PsrA	Oleic acid responsive regulator

NZ_JAQDYA010000007.1 - Region 2 - betalactone

Download region GenBank file

Download region SVG

Location: 26,212 - 58,744 nt. (total: 32,533 nt) Show pHMM detection rules used

betalactone: (HMGL-like and AMP-binding)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: carboxylase

PGT72_RS09640: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: ligase

PGT72_RS09675: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002116.3	0.41	ribosomal	darobactin A	Photorhabdus khanii HGB 1456
BGC0000501.3	0.40	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0001579.4	0.39	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0001391.3	0.37	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000412.5	0.36	NRPS	pyochelin	Pseudomonas aeruginosa PAO1
BGC0000904.5	0.35	other (other)	FR-900098	Streptomyces rubellomurinus
BGC0002092.3	0.34	NRPS	stechlisin B2, stechlisin C3, stechlisin D3, tensin, stechlisin E2, stechlisin F	Pseudomonas sp.
BGC0000497.3	0.34	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0002681.3	0.34	other (other)	rhizoferrin	Francisella tularensis subsp. tularensis SCHU S4
BGC0002699.2	0.34	ribosomal	nostolysamide A, nostolysamide B	Nostoc punctiforme PCC 73102

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002116.3	0.41	ribosomal	darobactin A	Photorhabdus khanii HGB 1456
BGC0000501.3	0.40	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0001579.4	0.39	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0001391.3	0.37	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000412.5	0.36	NRPS	pyochelin	Pseudomonas aeruginosa PAO1
BGC0000904.5	0.35	other (other)	FR-900098	Streptomyces rubellomurinus
BGC0002092.3	0.34	NRPS	stechlisin B2, stechlisin C3, stechlisin D3, tensin, stechlisin E2, stechlisin F	Pseudomonas sp.
BGC0000497.3	0.34	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0002681.3	0.34	other (other)	rhizoferrin	Francisella tularensis subsp. tularensis SCHU S4
BGC0002699.2	0.34	ribosomal	nostolysamide A, nostolysamide B	Nostoc punctiforme PCC 73102

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 25.74 out of 30.25

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.11 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.98 out of 27.78

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.76 out of 27.78

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.05 out of 20.97

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.90 out of 27.78

Confidence: strong

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.20 out of 26.33

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.34 out of 28.19

Confidence: medium

Additional weak hits (2):

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.59 out of 29.25

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 23.17 out of 35.63

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
MogR	Repressor of flagellar motility genes
ZuR variant 1	Zinc-responsive repressor