Select genomic region:
Overview
1.1
1.2
2.1
4.1
18.1
22.1
22.2

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_JAQDYA010000001.1 (Lactococcus lactis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | T3PKS,lanthipeptide-class-ii | 1 | 39,422 | Medium | carnolysin A1/carnolysin A2 | ribosomal:RiPP:Lanthipeptide
Region 1.2 | RaS-RiPP | 407,877 | 431,094 |

NZ_JAQDYA010000010.1 (Lactococcus lactis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 2.1 | terpene-precursor | 20,480 | 41,337 |

NZ_JAQDYA010000012.1 (Lactococcus lactis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 4.1 | RaS-RiPP | 12,163 | 36,065 |

NZ_JAQDYA010000003.1 (Lactococcus lactis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 18.1 | RiPP-like | 1 | 11,081 |

NZ_JAQDYA010000007.1 (Lactococcus lactis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 22.1 | lanthipeptide-class-i | 1 | 25,090 | High | nisin A | ribosomal:RiPP:Lanthipeptide
Region 22.2 | betalactone | 26,212 | 58,744 |

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | T3PKS,lanthipeptide-class-ii | 1 | 39,422 | Medium | carnolysin A1/carnolysin A2 | ribosomal:RiPP:Lanthipeptide
Region 1.2 | RaS-RiPP | 407,877 | 431,094 |
Region 2.1 | terpene-precursor | 20,480 | 41,337 |
Region 4.1 | RaS-RiPP | 12,163 | 36,065 |
Region 18.1 | RiPP-like | 1 | 11,081 |
Region 22.1 | lanthipeptide-class-i | 1 | 25,090 | High | nisin A | ribosomal:RiPP:Lanthipeptide
Region 22.2 | betalactone | 26,212 | 58,744 |

No secondary metabolite regions were found in these records:
  NZ_JAQDYA010000011.1 (Lactococcus lactis)
  NZ_JAQDYA010000013.1 (Lactococcus lactis)
  NZ_JAQDYA010000014.1 (Lactococcus lactis)
  NZ_JAQDYA010000015.1 (Lactococcus lactis)
  NZ_JAQDYA010000016.1 (Lactococcus lactis)
  NZ_JAQDYA010000017.1 (Lactococcus lactis)
  NZ_JAQDYA010000018.1 (Lactococcus lactis)
  NZ_JAQDYA010000019.1 (Lactococcus lactis)
  NZ_JAQDYA010000002.1 (Lactococcus lactis)
  NZ_JAQDYA010000020.1 (Lactococcus lactis)
  NZ_JAQDYA010000021.1 (Lactococcus lactis)
  NZ_JAQDYA010000022.1 (Lactococcus lactis)
  NZ_JAQDYA010000023.1 (Lactococcus lactis)
  NZ_JAQDYA010000024.1 (Lactococcus lactis)
  NZ_JAQDYA010000004.1 (Lactococcus lactis)
  NZ_JAQDYA010000005.1 (Lactococcus lactis)
  NZ_JAQDYA010000006.1 (Lactococcus lactis)
  NZ_JAQDYA010000008.1 (Lactococcus lactis)
  NZ_JAQDYA010000009.1 (Lactococcus lactis)

Compact view
NZ_JAQDYA010000001.1 - Region 1 - T3PKS,lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 39,422 nt. (total: 39,422 nt) Show pHMM detection rules used
Region on contig edge.
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
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Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase reductase
PGT72_RS00070: hydroxymethylglutaryl-CoA reductase

smcogs
  SMCOG1187: hydroxymethylglutaryl-CoA reductase

PGT72_RS00155: dehydrogenase

smcogs
  SMCOG1181: dehydrogenase

Transferases: acetyltransferase
PGT72_RS00065: acetyl-CoA acetyltransferase

smcogs
  SMCOG1124: acetyl-CoA acetyltransferase

Hydrolases: protease
PGT72_RS00035: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase
PGT72_RS00015: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Ligases: synthase
PGT72_RS00060: hydroxymethylglutaryl-CoA synthase

smcogs
  SMCOG1043: hydroxymethylglutaryl-CoA synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000504.5 |  |  | 0.62 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000500.5 |  |  | 0.42 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0001210.5 |  |  | 0.40 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000502.5 |  |  | 0.38 | ribosomal | cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7 | Bacillus cereus
BGC0000517.4 |  |  | 0.37 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000554.4 |  |  | 0.37 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001407.5 |  |  | 0.36 | ribosomal | bicereucin | Bacillus cereus SJ1
BGC0000525.5 |  |  | 0.36 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000516.4 |  |  | 0.35 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0002698.2 |  |  | 0.35 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000504.5 |  | 0.65 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0001210.5 |  | 0.55 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000502.5 |  | 0.54 | ribosomal | cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7 | Bacillus cereus
BGC0000500.5 |  | 0.53 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000516.4 |  | 0.53 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000517.4 |  | 0.53 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000527.5 |  | 0.52 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0001407.5 |  | 0.51 | ribosomal | bicereucin | Bacillus cereus SJ1
BGC0000866.5 |  | 0.51 | other (other) | polyhydroxyalkanoate | Burkholderia sp. DSM 9242
BGC0002698.2 |  | 0.50 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for PGT72_RS00015

PGT72_RS00020
Leader:
MKDTNINQNKVVGESFEDLSISEMMKIQGS
Core:
G D I T P E S T P V C A A F A T L A S G I A L V K T I K G N C
Core with dehydrations:
G D I Dhb P E Dha Dhb P V Cys A A F A Dhb L A Dha G I A L V K Dhb I K G N Cys

#### antiSMASH-DB 4.0 matches for PGT72_RS00020

100.0%
NZ_JAQDYA010000001.1:
Lanthipeptides: PGT72_RS00020_lanthipeptide
1
G D I T P E S T P V C A A F A T L A S G I A L V K T I K G N C
31
G D I T P E S T P V C A A F A T L A S G I A L V K T I K G N C
1
G D I T P E S T P V C A A F A T L A S G I A L V K T I K G N C
31
74.2%
NZ_JQBU01000033.1 and 1 other:
NZ_JQBV01000009.1 Lanthipeptides: IV76_RS12120_lanthipeptide
Lanthipeptides: IV75_RS14620_lanthipeptide
1
G D I T P E S T P V C A A F A T L A S G I A L V K T I K G N C
31
G D+ P E S T P+C A F A T L S I L V K T I K G C
1
G D V M P E S T P I C A G F A T L M S S I G L V K T I K G K C
31
67.7%
NZ_CP102973.1 and 1 other:
NZ_FQQG01000014.1 Lanthipeptides: BT790_RS14420_lanthipeptide
Lanthipeptides: NW963_RS14100_lanthipeptide
1
G D I T P E S T P V C A A F A T L A S G I A L V K T I K G N C
31
G D+T P E S T V C A A F A+ A I L V K T+K C
1
G D V T P E S T T V C A A F A S F A G S I Q L V K T L K S K C
31
with 103 more sequence matches
Only the first 10 are displayed here.
67.7%
NZ_JAFLVY010000007.1:
Lanthipeptides: JZO73_RS03920_lanthipeptide
1
G D I T P E S T P V C A A F A T L A S G I A L V K T I K G N C
31
G D+ P E S V + F A T L A S I A L V K T+K G+C
1
G D V N P E S--V A S F F A T L A S S I A L V K T L K G H C
29
51.6%
NZ_FUXI01000002.1:
Lanthipeptides: B5D30_RS01205_lanthipeptide
1
G D I T P E S T P V C A A F A T L A S G I A L V K T I K G N C
31
G D+ E+T V C A F A T I +V+T I K C
1
G D V N T E T T T V C A V F A T A C G A I Q V V R T I K K K C
31
48.4%
NZ_SDJV01000024.1:
Lanthipeptides: ES032_RS12700_lanthipeptide
1
G D I T P E S T P V C A A F A T L A S G I A L V K T I K G N C
31
G D+ E+T P C A A++ +V K T I K G+C
1
G D V Q V E T T P A C A F T A S I L V S Y G V V K T I K G H C
31
45.2%
NZ_CP086395.1 and 1 other:
NZ_JAKTAW010000012.1 Lanthipeptides: MKK30_RS11185_lanthipeptide
Lanthipeptides: LMK00_RS10670_lanthipeptide
1
G D I T P E S T P V C A A F A T L A S G I A L V K T I K G N C
31
G D+ S T P+C A + I +V K T+K G C
1
G D V E V R S T P I C T F T A G V T V S I V I V K T L K G R C
31
45.0%
NZ_JAFHCX010000012.1 and 1 other:
NZ_LR738722.1 Lanthipeptides: STREPSUIS_RS04075_lanthipeptide
Lanthipeptides: JXW96_RS06965_lanthipeptide
1
G D I T P E S T P V C A---------A F A T L A S G I A L V K T I K G N C
31
G D I+P E+T P C A A + A + +V K T+K G N C
1
G D I S P E T T P A C A L I I S K A I S G A A V S F A F S V G V V K T V K G N C
40
44.4%
NZ_JADNGS010000002.1:
Lanthipeptides: I2D92_RS06840_lanthipeptide
1
G D I T P E S T P V C A A F-----A T L A S G I A L V K T I K G N C
31
G D I P S V +A A T + I A+ K T+K G C
1
G D I E P N S L T V A S A V L M S A A A T G S F S I A V T K T V K G K C
36
43.8%
NZ_JADMPO010000001.1:
Lanthipeptides: I2I27_RS01390_lanthipeptide
1
G D I T P E-S T P V C A A F A T L A S G I A L V K T I K G N C
31
G D+ E +T P+C A T + I + K T+K G C
1
G D V E G E V T T P I C A V A V T A S L S I Q V A K T L K G K C
32
41.9%
NZ_FNYB01000007.1 and 2 others:
NZ_JAIPUK010000011.1 Lanthipeptides: K9P71_RS27180_lanthipeptide NZ_KB976303.1 Lanthipeptides: IGY_RS27695_lanthipeptide
Lanthipeptides: BMZ34_RS15960_lanthipeptide
1
G D I T P E S T P V C A A F A T L A S G I A L V K
25
G D+ P E+T P V C A L A G ++ K
1
G D V Q P E T T P V C A I G G G L A L G F S I S K
25
41.9%
NZ_FTML01000041.1:
Lanthipeptides: BW937_RS20030_lanthipeptide
1
G D I T P E S T P V C A A F A T L A S G I A L V K T I
27
G D+ P E S T P C A + G I A+ K +
1
G D V Q P E S T P A C V G-A G I T V G I A I S K L L
26
41.9%
NZ_JACDUU010000003.1:
Lanthipeptides: HNQ85_RS08040_lanthipeptide
1
G D I T P E S T P V C A A F A T L A S G I A L V K
25
G D+ P E+T V C A ++ G I A L K
1
G D V Q P E T T T V C A I G G G I S L G I A L S K
25
PGT72_RS00025
Leader:
MEKLNINQIVGDTFEDLTISEMVQIQGS
Core:
G D I T P E T T P V C A A T V A S S A Y C A G A A S A V S G I V L S V F K C
Core with dehydrations:
G D I Dhb P E Dhb Dhb P V Cys A A Dhb V A Dha Dha A Y Cys A G A A Dha A V Dha G I V L Dha V F K Cys

#### antiSMASH-DB 4.0 matches for PGT72_RS00025

100.0%
NZ_JAQDYA010000001.1:
Lanthipeptides: PGT72_RS00025_lanthipeptide
1
G D I T P E T T P V C A A T V A S S A Y C A G A A S A V S G I V L S V F K C
38
G D I T P E T T P V C A A T V A S S A Y C A G A A S A V S G I V L S V F K C
1
G D I T P E T T P V C A A T V A S S A Y C A G A A S A V S G I V L S V F K C
38
51.1%
NZ_JQBU01000033.1 and 1 other:
NZ_JQBV01000009.1 Lanthipeptides: IV76_RS12140_lanthipeptide
Lanthipeptides: IV75_RS14640_lanthipeptide
1
G D I T P E--T T P V C A A T V-----A S S A Y C A G A A S A V S G I V L S V F K C
38
G D I E T+P C +V A S S A C A A S A V S G +L S +C
1
G D I N G E F T T S P A C V Y S V M V V S K A S S A K C A A G A S A V S G A I L S A I R C
45
51.0%
NZ_QICS01000003.1:
Lanthipeptides: C8E03_RS08695_lanthipeptide
1
G D I T P E--T T P V C-----A A T V A S S A Y C----A G A A S A V S G I V L S V F K C
38
G D+ E T+P C A A T A S S A C A G A S V S G V S K C
1
G D V G A E F T T S P A C V A L S V A A T Q A S S A R C A I A S A G V A S L V S G A V H S A L K C
49
with 119 more sequence matches
Only the first 10 are displayed here.
50.0%
NC_014098.1:
Lanthipeptides: BTUS_RS14190_lanthipeptide
1
G D I T P E T T P V C---A A T V A S S A Y C A G-A A S A V S G--I V L S V F K C
38
G D+ E T T P+C A A S S A C A G A V+G I V L++ +C
1
G D V Q A E T T P I C Y T A A T V T A S S A A C A G V G A G I V A G V T I V L T I K R C
44
48.8%
NZ_JACWFH010000015.1:
Lanthipeptides: H0185_RS13725_lanthipeptide
1
G D I T P E T T-----P V C A A T V A S S A Y C A G A A S A V S G I V L S V F K C
38
G D+ E T T V V S S C A A A A V G+ L S V+K C
1
G D V Q G E T T T F P C F A V A Y Y G V Q S S V S C A Y A A G A V V G V G L S V W K C
43
47.5%
NZ_SDJV01000024.1:
Lanthipeptides: ES032_RS12705_lanthipeptide
1
G D I T P E T T P V C A A T V-----A S S A Y C A G A A S A V S G I V L S V F K C
38
G D+ E T T P C +V S S +C A G A G V+S+ K C
1
G D V Q V E T T P A C L Y S V Y V T A N V S S V W C A G A T---V G A V I S I V K C
40
47.4%
NZ_CP048887.1:
Lanthipeptides: BMG_RS29400_lanthipeptide
1
G D I T P E T T P V C A A T V A S S A Y C A G A A S A V S G I V L S V F K C
38
G D+ P E T T P V V S S A C G V+G ++S+ C
1
G D V Q P E T T P V---A V T S S A V C I G----V T G A I I S I K Y C
31
45.5%
NZ_CP025701.1:
Lanthipeptides: C0569_RS26130_lanthipeptide
1
G D I T P E T T P V C---A A T V A S S A Y C A----G A A S A V S G I V L S V F K C
38
G D+ E T T P V C A A S S C A G A+ V+ +V+S+ C
1
G D V Q A E T T P V C A I A A T A A A S S G I C A A T G G G I A T G V T-V V V S L K H C
44
45.5%
NZ_NVAW01000030.1 and 1 other:
NZ_NVEP01000021.1 Lanthipeptides: COL17_RS24440_lanthipeptide
Lanthipeptides: COK11_RS25880_lanthipeptide
1
G D I T P E T T P V C---A A T V A S S A Y C----A G A A S A V S G I V L S V F K C
38
G D+ E T T P V C A A S S C A G A+ V+ +V+S+ C
1
G D V Q A E T T P V C A V A A T A A A S S G V C A A T G A G I A T G V T-V V V S L K S C
44
45.0%
NZ_JAQCQD010000003.1:
Lanthipeptides: PGZ38_RS05480_lanthipeptide
1
G D I T P E T T P V C A A T V A S S A Y C A G A A S A V S G I V L S V F K
37
G D I+P E T T P C A + S +G A A + G +S V K
1
G D I S P E T T P A C A L I I--S K I I S G A A V S F-G F S V S V V K
34
44.9%
NZ_JADNGS010000002.1:
Lanthipeptides: I2D92_RS06835_lanthipeptide
1
G D I T P E--T T P V C-----A A T V A S S A Y C A G A----A S A V S G I V L S V F K C
38
G D++ E T+P C A A+ A S S C A A S V S V L S K C
1
G D V S G E F T T S P A C V Y V S V A A S R A S S Q K C G Q A S G A I A S F V S T A V L S A V K C
49
44.0%
NZ_JAQCQD010000003.1:
Lanthipeptides: PGZ38_RS05485_lanthipeptide
1
G D I T P E---T T P V C A A T V-----A S S A Y C A G A----A S A V S G I V L S V F K C
38
G D++ E T T P C A++ A S S C A A +S A+S G V+S K C
1
G D M S A E L T P T T P A C F A S I I Y T A R A S S P N C A H A L S V I S S A I S G A V I S A V K C
50
42.5%
NZ_CP011152.1 and 3 others:
NZ_CP011152.1 Lanthipeptides: WR47_RS28830_lanthipeptide NZ_CP011152.1 Lanthipeptides: WR47_RS28835_lanthipeptide NZ_CP011152.1 Lanthipeptides: WR47_RS28830_lanthipeptide
Lanthipeptides: WR47_RS28835_lanthipeptide
1
G D I T P E T T P V C A A T V A S S A Y C A G A A S A V S G I V L S V F K C
38
G D+T P+ T P T V A A G A V V L K C
1
G D V T P Q A T P----T V T I L A T A A G G--A V I S A V L P T L K C
32
allorf_000137_000301
Leader:
MFNTNLNNCFKFNFSEGCKRSLPSVTLSVFLIFPLNYSRFYYTISTKMIFG
Core:
C V S
Core with dehydrations:
Cys V Dha
allorf_000494_000628
Leader:
MSNLVSAKFLDHCTAM
Core:
I Y G E I E R Y F I G N K K V K L V D Q A I T C F K N Q
Core with dehydrations:
I Y G E I E R Y F I G N K K V K L V D Q A I Dhb Cys F K N Q

#### antiSMASH-DB 4.0 matches for allorf_000494_000628

100.0%
NZ_JAQDYA010000001.1:
Lanthipeptides: allorf_000494_000628_lanthipeptide
1
I Y G E I E R Y F I G N K K V K L V D Q A I T C F K N Q
28
I Y G E I E R Y F I G N K K V K L V D Q A I T C F K N Q
1
I Y G E I E R Y F I G N K K V K L V D Q A I T C F K N Q
28

#### MIBiG 4.0 matches for allorf_000494_000628

21.4%
BGC0002322.3 (CEJ66604.1):
Lasso peptide: citrocin
3
G E I E R Y F I G N
12
G+I Y F I G
4
G K I I E Y F I G G
13
allorf_010404_010511
Leader:
MQLIAIIFM
Core:
M F H K S S S E S C R T S N S H S K I N Y C L H R K
Core with dehydrations:
M F H K Dha Dha Dha E Dha Cys R Dhb Dha N Dha H Dha K I N Y Cys L H R K

#### antiSMASH-DB 4.0 matches for allorf_010404_010511

100.0%
NZ_JAQDYA010000001.1:
Lanthipeptides: allorf_010404_010511_lanthipeptide
1
M F H K S S S E S C R T S N S H S K I N Y C L H R K
26
M F H K S S S E S C R T S N S H S K I N Y C L H R K
1
M F H K S S S E S C R T S N S H S K I N Y C L H R K
26
30.8%
NZ_CP069611.1:
Lanthipeptides: allorf_29777_29872_lanthipeptide
11
R T S N S H S K I N Y C L H R K
26
R+S N +K Y C+ R K
2
R S S N I L T K S V Y C V P R K
17
30.8%
NZ_KB903814.1:
Lanthipeptides: allorf_845501_845632_lanthipeptide
5
S S S E S C R T S N S H S K I N Y C L H R
25
S S S + R T+ + C H R
6
S S S G A S R T A A R G P A V R P C C H R
26

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.21 out of 26.06
Confidence: strong
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 19.86 out of 21.84
Confidence: medium
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.74 out of 28.14
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.76 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.30 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.41 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.26 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.92 out of 27.78
Confidence: medium
Additional weak hits (6):
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.57 out of 25.75
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.42 out of 31.73
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.35 out of 36.54
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 23.28 out of 30.98
Confidence: weak
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 15.91 out of 20.47
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

PGT72_RS00020 - Class II
  Cleavage pHMM score: 0.30
  RODEO score: 0
  Monoisotopic mass: 2939.6 Da
  Molecular weight: 2941.4 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2959.4 Da N = 1
    2977.4 Da N = 2
    2995.5 Da N = 3
    3013.5 Da N = 4
PGT72_RS00025 - Class II
  Cleavage pHMM score: 1.10
  RODEO score: 0
  Monoisotopic mass: 3454.7 Da
  Molecular weight: 3456.9 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3474.9 Da N = 1
    3493.0 Da N = 2
    3511.0 Da N = 3
    3529.0 Da N = 4
    3547.0 Da N = 5
    3565.0 Da N = 6
allorf_000137_000301 - Class II
  Cleavage pHMM score: -6.70
  RODEO score: 0
  Monoisotopic mass: 289.1 Da
  Molecular weight: 289.3 Da
  Number of bridges: 1
allorf_000494_000628 - Class II
  Cleavage pHMM score: -6.90
  RODEO score: 0
  Monoisotopic mass: 3298.8 Da
  Molecular weight: 3300.8 Da
  Number of bridges: 1
allorf_010404_010511 - Class II
  Cleavage pHMM score: -5.40
  RODEO score: 0
  Monoisotopic mass: 2922.4 Da
  Molecular weight: 2924.3 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2942.3 Da N = 1
    2960.3 Da N = 2
    2978.3 Da N = 3
    2996.3 Da N = 4
    3014.4 Da N = 5
    3032.4 Da N = 6

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MexT | Global virulence regulator
MogR | Repressor of flagellar motility genes
PerR | Peroxide regulator

NZ_JAQDYA010000001.1 - Region 2 - RaS-RiPP
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 407,877 - 431,094 nt. (total: 23,218 nt) Show pHMM detection rules used
RaS-RiPP: (PF04055 and TIGR01716)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Translocases: transporter
PGT72_RS01850: sugar-binding lipoprotein

smcogs
  SMCOG1143: sugar-binding lipoprotein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RaS-RiPP | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001209.3 |  | 0.46 | ribosomal | streptide | Streptococcus thermophilus LMD-9
BGC0002322.3 |  | 0.41 | ribosomal | citrocin | Citrobacter pasteurii
BGC0000616.4 |  | 0.40 | ribosomal | amylocyclicin | Bacillus velezensis FZB42
BGC0002005.2 |  | 0.40 | ribosomal | RaxX | Xanthomonas oryzae pv. oryzae
BGC0001639.3 |  | 0.40 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0002583.2 |  | 0.40 | ribosomal | tryglysin B | Streptococcus mutans UA159
BGC0001929.2 |  | 0.39 | ribosomal | WGK | Streptococcus ferus
BGC0000518.3 |  | 0.39 | ribosomal | informatipeptin | Streptomyces viridochromogenes DSM 40736
BGC0001391.3 |  | 0.39 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni
BGC0002447.3 |  | 0.39 | ribosomal | cerecyclin | Bacillus cereus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001209.3 |  | 0.46 | ribosomal | streptide | Streptococcus thermophilus LMD-9
BGC0002322.3 |  | 0.41 | ribosomal | citrocin | Citrobacter pasteurii
BGC0000616.4 |  | 0.40 | ribosomal | amylocyclicin | Bacillus velezensis FZB42
BGC0002005.2 |  | 0.40 | ribosomal | RaxX | Xanthomonas oryzae pv. oryzae
BGC0001639.3 |  | 0.40 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0002583.2 |  | 0.40 | ribosomal | tryglysin B | Streptococcus mutans UA159
BGC0001929.2 |  | 0.39 | ribosomal | WGK | Streptococcus ferus
BGC0000518.3 |  | 0.39 | ribosomal | informatipeptin | Streptomyces viridochromogenes DSM 40736
BGC0001391.3 |  | 0.39 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni
BGC0002447.3 |  | 0.39 | ribosomal | cerecyclin | Bacillus cereus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.06 out of 27.78
Confidence: medium
Additional weak hits (3):
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.77 out of 36.54
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.90 out of 28.14
Confidence: weak
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.72 out of 26.85
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria

NZ_JAQDYA010000010.1 - Region 1 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 20,480 - 41,337 nt. (total: 20,858 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Ligases: synthetase
PGT72_RS10970: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0001756.3 |  | 0.29 | terpene | retigeranin, arathanatriene | Arabidopsis thaliana
BGC0001605.3 |  | 0.28 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0001227.3 |  | 0.27 | terpene | isorenieratene | Streptomyces collinus Tu 365
BGC0000633.3 |  | 0.27 | terpene | carotenoid | Streptomyces avermitilis
BGC0000648.3 |  | 0.27 | terpene | carotenoid | Myxococcus xanthus
BGC0001529.5 |  | 0.27 | other (other) | benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K | Streptomyces sp. RI18
BGC0001456.3 |  | 0.27 | terpene | isorenieratene | Streptomyces argillaceus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0001756.3 |  | 0.29 | terpene | retigeranin, arathanatriene | Arabidopsis thaliana
BGC0001605.3 |  | 0.28 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0001227.3 |  | 0.27 | terpene | isorenieratene | Streptomyces collinus Tu 365
BGC0000633.3 |  | 0.27 | terpene | carotenoid | Streptomyces avermitilis
BGC0000648.3 |  | 0.27 | terpene | carotenoid | Myxococcus xanthus
BGC0001529.5 |  | 0.27 | other (other) | benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K | Streptomyces sp. RI18
BGC0001456.3 |  | 0.27 | terpene | isorenieratene | Streptomyces argillaceus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
PGT72_RS10970: PT_FPPS_like
Domain 1 (25 - 281): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  DMAPP, IPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.27 out of 26.06
Confidence: strong
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.74 out of 28.14
Confidence: medium
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 30.52 out of 30.97
Confidence: strong
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.82 out of 21.84
Confidence: medium
Additional weak hits (3):
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 23.05 out of 33.73
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 19.12 out of 30.11
Confidence: weak
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.48 out of 19.52
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CopR | Copper-responsive regulator
MexT | Global virulence regulator
MogR | Repressor of flagellar motility genes
PerR | Peroxide regulator

NZ_JAQDYA010000012.1 - Region 1 - RaS-RiPP
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 12,163 - 36,065 nt. (total: 23,903 nt) Show pHMM detection rules used
RaS-RiPP: (PF04055 and TIGR01716)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
PGT72_RS11355: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RaS-RiPP | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001209.3 |  | 0.48 | ribosomal | streptide | Streptococcus thermophilus LMD-9
BGC0001929.2 |  | 0.46 | ribosomal | WGK | Streptococcus ferus
BGC0000779.3 |  | 0.38 | saccharide | lipopolysaccharide | Aeromonas piscicola
BGC0002287.2 |  | 0.37 | NRPS | mutanocyclin, leuvalin, tyrvalin | Streptococcus mutans
BGC0000938.5 |  | 0.37 | other (aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0000806.5 |  | 0.29 | saccharide | phosphonoglycans | Glycomyces sp. NRRL B-16210
BGC0001055.5 |  | 0.29 | NRPS, PKS | yersiniabactin | Escherichia coli
BGC0000982.5 |  | 0.28 | NRPS, PKS | cystothiazole A | Cystobacter fuscus
BGC0000780.3 |  | 0.24 | saccharide | O&K-antigen | Vibrio parahaemolyticus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001209.3 |  | 0.48 | ribosomal | streptide | Streptococcus thermophilus LMD-9
BGC0001929.2 |  | 0.46 | ribosomal | WGK | Streptococcus ferus
BGC0000779.3 |  | 0.38 | saccharide | lipopolysaccharide | Aeromonas piscicola
BGC0002287.2 |  | 0.37 | NRPS | mutanocyclin, leuvalin, tyrvalin | Streptococcus mutans
BGC0000938.5 |  | 0.37 | other (aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0000806.5 |  | 0.29 | saccharide | phosphonoglycans | Glycomyces sp. NRRL B-16210
BGC0001055.5 |  | 0.29 | NRPS, PKS | yersiniabactin | Escherichia coli
BGC0000982.5 |  | 0.28 | NRPS, PKS | cystothiazole A | Cystobacter fuscus
BGC0000780.3 |  | 0.24 | saccharide | O&K-antigen | Vibrio parahaemolyticus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.21 out of 26.06
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.27 out of 26.06
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.23 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.11 out of 26.06
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.06 out of 19.26
Confidence: strong
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26
Confidence: medium
Additional weak hits (2):
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.19 out of 28.14
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.90 out of 32.74
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
MogR | Repressor of flagellar motility genes

NZ_JAQDYA010000003.1 - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 11,081 nt. (total: 11,081 nt) Show pHMM detection rules used
Region on contig edge.
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000617.5 |  | 0.50 | ribosomal | coagulin | Bacillus coagulans
BGC0002579.2 |  | 0.48 | ribosomal | carnobacteriocin XY | Carnobacterium maltaromaticum
BGC0000624.3 |  | 0.46 | ribosomal | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0002577.2 |  | 0.44 | ribosomal | lactococcin G | Lactococcus lactis
BGC0001388.3 |  | 0.44 | ribosomal | gassericin E | Lactobacillus gasseri
BGC0000619.3 |  | 0.44 | ribosomal | gassericin T | Lactobacillus gasseri
BGC0001602.3 |  | 0.44 | ribosomal | gassericin-T | Lactobacillus gasseri
BGC0001229.4 |  | 0.43 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000558.5 |  | 0.42 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0002005.2 |  | 0.40 | ribosomal | RaxX | Xanthomonas oryzae pv. oryzae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000617.5 |  | 0.50 | ribosomal | coagulin | Bacillus coagulans
BGC0002579.2 |  | 0.48 | ribosomal | carnobacteriocin XY | Carnobacterium maltaromaticum
BGC0000624.3 |  | 0.46 | ribosomal | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0002577.2 |  | 0.44 | ribosomal | lactococcin G | Lactococcus lactis
BGC0001388.3 |  | 0.44 | ribosomal | gassericin E | Lactobacillus gasseri
BGC0000619.3 |  | 0.44 | ribosomal | gassericin T | Lactobacillus gasseri
BGC0001602.3 |  | 0.44 | ribosomal | gassericin-T | Lactobacillus gasseri
BGC0001229.4 |  | 0.43 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000558.5 |  | 0.42 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0002005.2 |  | 0.40 | ribosomal | RaxX | Xanthomonas oryzae pv. oryzae

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.72 out of 27.78
Confidence: medium
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.10 out of 32.93
Confidence: medium
Additional weak hits (3):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.93 out of 29.38
Confidence: weak
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 15.78 out of 18.46
Confidence: weak
DosR
Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.65 out of 29.51
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 3 | Repressor of DNA damage response

NZ_JAQDYA010000007.1 - Region 1 - lanthipeptide-class-i
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 25,090 nt. (total: 25,090 nt) Show pHMM detection rules used
Region on contig edge.
lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: protease
PGT72_RS09530: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase dehydratase
PGT72_RS09540: Lanthionine synthetase C family protein

smcogs
  SMCOG1140: Lanthionine synthetase C family protein

PGT72_RS09555: Lantibiotic dehydratase domain protein

smcogs
  SMCOG1155: Lantibiotic dehydratase domain protein

Ligases: synthase
PGT72_RS09590: polyprenol-monophosphomannose synthase ppm1

smcogs
  SMCOG1123: polyprenol-monophosphomannose synthase ppm1

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-i | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000535.4 |  | 0.94 | ribosomal | nisin A | Lactococcus lactis subsp. lactis
BGC0000538.3 |  | 0.88 | ribosomal | nisin Z | Lactococcus lactis
BGC0000536.3 |  | 0.84 | ribosomal | nisin Q | Lactococcus lactis
BGC0001789.3 |  | 0.74 | ribosomal | suicin 90-1330 | Streptococcus suis
BGC0000537.3 |  | 0.72 | ribosomal | nisin U | Streptococcus uberis
BGC0000549.3 |  | 0.67 | ribosomal | salivaricin D | Streptococcus salivarius
BGC0000542.3 |  | 0.60 | ribosomal | paenicidin B | Paenibacillus terrae
BGC0002323.2 |  | 0.58 | ribosomal | nisin J | Staphylococcus capitis
BGC0000541.5 |  | 0.57 | ribosomal | paenicidin A | Paenibacillus polymyxa
BGC0001289.5 |  | 0.57 | ribosomal | penisin | Paenibacillus ehimensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000535.4 |  | 0.94 | ribosomal | nisin A | Lactococcus lactis subsp. lactis
BGC0000538.3 |  | 0.88 | ribosomal | nisin Z | Lactococcus lactis
BGC0000536.3 |  | 0.84 | ribosomal | nisin Q | Lactococcus lactis
BGC0001789.3 |  | 0.74 | ribosomal | suicin 90-1330 | Streptococcus suis
BGC0000537.3 |  | 0.72 | ribosomal | nisin U | Streptococcus uberis
BGC0000549.3 |  | 0.67 | ribosomal | salivaricin D | Streptococcus salivarius
BGC0000542.3 |  | 0.60 | ribosomal | paenicidin B | Paenibacillus terrae
BGC0002323.2 |  | 0.58 | ribosomal | nisin J | Staphylococcus capitis
BGC0000541.5 |  | 0.57 | ribosomal | paenicidin A | Paenibacillus polymyxa
BGC0001289.5 |  | 0.57 | ribosomal | penisin | Paenibacillus ehimensis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for PGT72_RS09550

PGT72_RS09560
Leader:
MSTKDFNLDLVSVSKKDSGASPR
Core:
I T S I S L C T P G C K T G A L M G C N M K T A T C N C S I H V S R
Core with dehydrations:
I Dhb Dha I Dha L Cys Dhb P G Cys K Dhb G A L M G Cys N M K Dhb A Dhb Cys N Cys Dha I H V Dha R

#### antiSMASH-DB 4.0 matches for PGT72_RS09560

100.0%
NZ_JAQDYA010000007.1 and 1 other:
NZ_JAQDYA010000007.1 Lanthipeptides: PGT72_RS09560_lanthipeptide
Lanthipeptides: PGT72_RS09560_lanthipeptide
1
I T S I S L C T P G C K T G A L M G C N M K T A T C N C S I H V S R
34
I T S I S L C T P G C K T G A L M G C N M K T A T C N C S I H V S R
1
I T S I S L C T P G C K T G A L M G C N M K T A T C N C S I H V S R
34
97.1%
NC_013656.1 and 18 others:
NC_020450.1 Lanthipeptides: LILO_RS03015_lanthipeptide NZ_CP009472.1 Lanthipeptides: LG36_RS03420_lanthipeptide NZ_CP010050.1 Lanthipeptides: QI18_RS03300_lanthipeptide NZ_CP015903.1 Lanthipeptides: LLUC08_RS03255_lanthipeptide NZ_CP024954.1 Lanthipeptides: CV702_RS02990_lanthipeptide NZ_CP066300.1 Lanthipeptides: LacL0098_RS03205_lanthipeptide NZ_CP098790.1 Lanthipeptides: M5C73_RS03405_lanthipeptide NZ_JAALEQ010000006.1 Lanthipeptides: HFD15_RS10120_lanthipeptide NZ_JAJONJ010000005.1 Lanthipeptides: LSG16_RS07195_lanthipeptide NZ_JAQDWM010000007.1 Lanthipeptides: PGU01_RS08180_lanthipeptide NZ_JAQDXV010000018.1 Lanthipeptides: PGT80_RS11850_lanthipeptide NZ_JAQEIZ010000019.1 Lanthipeptides: PGX18_RS12025_lanthipeptide NZ_JAQEOU010000022.1 Lanthipeptides: PGV42_RS12330_lanthipeptide NZ_JAQEOV010000015.1 Lanthipeptides: PGW09_RS10765_lanthipeptide NZ_MTJP01000006.1 Lanthipeptides: BW151_RS03795_lanthipeptide NZ_MTJR01000005.1 Lanthipeptides: BW153_RS02980_lanthipeptide NZ_MTJS01000002.1 Lanthipeptides: BW154_RS09850_lanthipeptide NZ_RAGL01000022.1 Lanthipeptides: D6108_RS11395_lanthipeptide
Lanthipeptides: LLKF_RS13210_lanthipeptide
1
I T S I S L C T P G C K T G A L M G C N M K T A T C N C S I H V S R
34
I T S I S L C T P G C K T G A L M G C N M K T A T C N C S I H V S+
1
I T S I S L C T P G C K T G A L M G C N M K T A T C N C S I H V S K
34
94.1%
NZ_CP065984.1 and 2 others:
NZ_CP095737.1 Lanthipeptides: MXM90_RS03205_lanthipeptide NZ_JAQDXJ010000021.1 Lanthipeptides: PGU19_RS11740_lanthipeptide
Lanthipeptides: I6I21_RS02785_lanthipeptide
1
I T S I S L C T P G C K T G A L M G C N M K T A T C N C S I H V S R
34
I T S I S L C T P G C K T G A L M G C N M K T A T C+C S I H V S+
1
I T S I S L C T P G C K T G A L M G C N M K T A T C H C S I H V S K
34
with 123 more sequence matches
Only the first 10 are displayed here.
82.4%
NZ_FBTD01000003.1:
Lanthipeptides: PB1E_RS03075_lanthipeptide
1
I T S I S L C T P G C K T G A L M G C N M K T A T C N C S I H V S R
34
I T S+S L C T P G C K T G A L M G C N M K T A+C C +H V S+
1
I T S V S L C T P G C K T G A L M G C N M K T A S C G C H V H V S K
34
79.4%
NZ_JADNFO010000025.1:
Lanthipeptides: I2C89_RS09745_lanthipeptide
1
I T S I S L C T P G C K T G A L M G C N M K T A T C N C S I H V S R
34
I T S S L C T P G C K T G L M C++K T A T C N C S I V S+
1
I T S Y S L C T P G C K T G V L M A C H L K T A T C N C S I I V S K
34
77.1%
NZ_FNDP01000013.1:
Lanthipeptides: BLP54_RS11230_lanthipeptide
1
I T S I S L C T P G C K T G A L M G C N M K T A T C N C S I H V
32
I T S S L C T P G C T G L M G C N K T A T C N C S+H V
3
I T S K S L C T P G C V T G V L M G C N N K T A T C N C S V H V
34
76.5%
NZ_CP090412.1 and 3 others:
NZ_QSTB01000004.1 Lanthipeptides: DXC22_RS03785_lanthipeptide NZ_VSTZ01000009.1 Lanthipeptides: FYK98_RS07445_lanthipeptide NZ_VSTZ01000009.1 Lanthipeptides: FYK98_RS07445_lanthipeptide
Lanthipeptides: LZF92_RS09890_lanthipeptide
1
I T S I S L C T P G C K T G A L M G C N M K T A T C N C S I H V S R
34
I T S S L C T P G C K T G A L M G C M K T A+C C +H+S+
1
I T S Y S L C T P G C K T G A L M G C T M K T A S C G C H V H I S K
34
68.6%
NZ_FNDP01000013.1 and 1 other:
NZ_FNDP01000013.1 Lanthipeptides: BLP54_RS11225_lanthipeptide
Lanthipeptides: BLP54_RS11220_lanthipeptide
1
I T S I S L C T P G C K T G A L M G C N M K T A T C N C S I H V
32
I T S S L C T P G C T G L M G C +A T C N C S+H V
3
I T S K S L C T P G C V T G L L M G C A G S S A T C N C S V H V
34
67.6%
NC_022237.1 and 1 other:
NZ_JUZI01000019.1 Lanthipeptides: ADI02_RS09325_lanthipeptide
Lanthipeptides: SII_RS05025_lanthipeptide
1
I T S I S L C T P G C K T G A L M G C N M K T A T C N C S I H V S R
34
+T S+ +C T P G C T G A L M G C N++T A T C N C +H+S+
1
V T S V F M C T P G C V T G A L M G C N L Q T A T C N C H V H I S K
34
67.6%
NZ_CP059471.1 and 3 others:
NZ_FNZW01000001.1 Lanthipeptides: BMZ61_RS02110_lanthipeptide NZ_FOYC01000001.1 Lanthipeptides: BMZ88_RS03370_lanthipeptide NZ_KE384124.1 Lanthipeptides: G597_RS0106700_lanthipeptide
Lanthipeptides: H1R75_RS06635_lanthipeptide
1
I T S I S L C T P G C K T G A L M G C N M K T A T C N C S I
30
I T S S L C T P G C K T G A L M C +K T A T C C
1
I T S K S L C T P G C K T G A L M T C P I K T A T C G C H F
30
65.7%
NZ_CP013655.1 and 2 others:
NZ_CP013655.1 Lanthipeptides: ATZ35_RS03635_lanthipeptide NZ_CP013655.1 Lanthipeptides: ATZ35_RS03630_lanthipeptide
Lanthipeptides: ATZ35_RS03640_lanthipeptide
1
I T S I S L C T P G C K T G A L M G C N M K T A T C N C S I H V S R
34
I T S S L C T P G C T G L M G C +K T T C N C S+ + +
1
I T S K S L C T P G C V T G V L M G C A L K T I T C N C S V G I G K
34
64.7%
NZ_CP024974.1 and 1 other:
NZ_JAIMDQ010000006.1 Lanthipeptides: K6V44_RS04045_lanthipeptide
Lanthipeptides: CVO91_RS06555_lanthipeptide
1
I T S I S L C T P G C K T G A L M G C N M K T A T C N C
28
+T S I S L C T P G C K T G L M C +K T A T C C
1
V T S I S L C T P G C K T G I L M T C A I K T A T C G C
28
64.7%
NZ_LR793265.1:
Lanthipeptides: HV392_RS09830_lanthipeptide
1
I T S I S L C T P G C K T G A L M G C N M K T A T C N C S I H V S R
34
I T S S L C T P G C T G L M G C ++A C N +H V S+
1
I T S Y S L C T P G C I T G V L M G C Q F Q S A G C N V H V H V S K
34

#### MIBiG 4.0 matches for PGT72_RS09560

94.1%
BGC0000535.4 (ADJ56352.1):
Lanthipeptide: nisin A
1
I T S I S L C T P G C K T G A L M G C N M K T A T C N C S I H V S R
34
I T S I S L C T P G C K T G A L M G C N M K T A T C+C S I H V S+
1
I T S I S L C T P G C K T G A L M G C N M K T A T C H C S I H V S K
34

#### Lanthipeptide(s) for PGT72_RS09555

PGT72_RS09560
Leader:
MSTKDFNLDLVSVSKKDSGASPR
Core:
I T S I S L C T P G C K T G A L M G C N M K T A T C N C S I H V S R
Core with dehydrations:
I Dhb Dha I Dha L Cys Dhb P G Cys K Dhb G A L M G Cys N M K Dhb A Dhb Cys N Cys Dha I H V Dha R

#### antiSMASH-DB 4.0 matches for PGT72_RS09560

100.0%
NZ_JAQDYA010000007.1 and 1 other:
NZ_JAQDYA010000007.1 Lanthipeptides: PGT72_RS09560_lanthipeptide
Lanthipeptides: PGT72_RS09560_lanthipeptide
1
I T S I S L C T P G C K T G A L M G C N M K T A T C N C S I H V S R
34
I T S I S L C T P G C K T G A L M G C N M K T A T C N C S I H V S R
1
I T S I S L C T P G C K T G A L M G C N M K T A T C N C S I H V S R
34
97.1%
NC_013656.1 and 18 others:
NC_020450.1 Lanthipeptides: LILO_RS03015_lanthipeptide NZ_CP009472.1 Lanthipeptides: LG36_RS03420_lanthipeptide NZ_CP010050.1 Lanthipeptides: QI18_RS03300_lanthipeptide NZ_CP015903.1 Lanthipeptides: LLUC08_RS03255_lanthipeptide NZ_CP024954.1 Lanthipeptides: CV702_RS02990_lanthipeptide NZ_CP066300.1 Lanthipeptides: LacL0098_RS03205_lanthipeptide NZ_CP098790.1 Lanthipeptides: M5C73_RS03405_lanthipeptide NZ_JAALEQ010000006.1 Lanthipeptides: HFD15_RS10120_lanthipeptide NZ_JAJONJ010000005.1 Lanthipeptides: LSG16_RS07195_lanthipeptide NZ_JAQDWM010000007.1 Lanthipeptides: PGU01_RS08180_lanthipeptide NZ_JAQDXV010000018.1 Lanthipeptides: PGT80_RS11850_lanthipeptide NZ_JAQEIZ010000019.1 Lanthipeptides: PGX18_RS12025_lanthipeptide NZ_JAQEOU010000022.1 Lanthipeptides: PGV42_RS12330_lanthipeptide NZ_JAQEOV010000015.1 Lanthipeptides: PGW09_RS10765_lanthipeptide NZ_MTJP01000006.1 Lanthipeptides: BW151_RS03795_lanthipeptide NZ_MTJR01000005.1 Lanthipeptides: BW153_RS02980_lanthipeptide NZ_MTJS01000002.1 Lanthipeptides: BW154_RS09850_lanthipeptide NZ_RAGL01000022.1 Lanthipeptides: D6108_RS11395_lanthipeptide
Lanthipeptides: LLKF_RS13210_lanthipeptide
1
I T S I S L C T P G C K T G A L M G C N M K T A T C N C S I H V S R
34
I T S I S L C T P G C K T G A L M G C N M K T A T C N C S I H V S+
1
I T S I S L C T P G C K T G A L M G C N M K T A T C N C S I H V S K
34
94.1%
NZ_CP065984.1 and 2 others:
NZ_CP095737.1 Lanthipeptides: MXM90_RS03205_lanthipeptide NZ_JAQDXJ010000021.1 Lanthipeptides: PGU19_RS11740_lanthipeptide
Lanthipeptides: I6I21_RS02785_lanthipeptide
1
I T S I S L C T P G C K T G A L M G C N M K T A T C N C S I H V S R
34
I T S I S L C T P G C K T G A L M G C N M K T A T C+C S I H V S+
1
I T S I S L C T P G C K T G A L M G C N M K T A T C H C S I H V S K
34
with 123 more sequence matches
Only the first 10 are displayed here.
82.4%
NZ_FBTD01000003.1:
Lanthipeptides: PB1E_RS03075_lanthipeptide
1
I T S I S L C T P G C K T G A L M G C N M K T A T C N C S I H V S R
34
I T S+S L C T P G C K T G A L M G C N M K T A+C C +H V S+
1
I T S V S L C T P G C K T G A L M G C N M K T A S C G C H V H V S K
34
79.4%
NZ_JADNFO010000025.1:
Lanthipeptides: I2C89_RS09745_lanthipeptide
1
I T S I S L C T P G C K T G A L M G C N M K T A T C N C S I H V S R
34
I T S S L C T P G C K T G L M C++K T A T C N C S I V S+
1
I T S Y S L C T P G C K T G V L M A C H L K T A T C N C S I I V S K
34
77.1%
NZ_FNDP01000013.1:
Lanthipeptides: BLP54_RS11230_lanthipeptide
1
I T S I S L C T P G C K T G A L M G C N M K T A T C N C S I H V
32
I T S S L C T P G C T G L M G C N K T A T C N C S+H V
3
I T S K S L C T P G C V T G V L M G C N N K T A T C N C S V H V
34
76.5%
NZ_CP090412.1 and 3 others:
NZ_QSTB01000004.1 Lanthipeptides: DXC22_RS03785_lanthipeptide NZ_VSTZ01000009.1 Lanthipeptides: FYK98_RS07445_lanthipeptide NZ_VSTZ01000009.1 Lanthipeptides: FYK98_RS07445_lanthipeptide
Lanthipeptides: LZF92_RS09890_lanthipeptide
1
I T S I S L C T P G C K T G A L M G C N M K T A T C N C S I H V S R
34
I T S S L C T P G C K T G A L M G C M K T A+C C +H+S+
1
I T S Y S L C T P G C K T G A L M G C T M K T A S C G C H V H I S K
34
68.6%
NZ_FNDP01000013.1 and 1 other:
NZ_FNDP01000013.1 Lanthipeptides: BLP54_RS11225_lanthipeptide
Lanthipeptides: BLP54_RS11220_lanthipeptide
1
I T S I S L C T P G C K T G A L M G C N M K T A T C N C S I H V
32
I T S S L C T P G C T G L M G C +A T C N C S+H V
3
I T S K S L C T P G C V T G L L M G C A G S S A T C N C S V H V
34
67.6%
NC_022237.1 and 1 other:
NZ_JUZI01000019.1 Lanthipeptides: ADI02_RS09325_lanthipeptide
Lanthipeptides: SII_RS05025_lanthipeptide
1
I T S I S L C T P G C K T G A L M G C N M K T A T C N C S I H V S R
34
+T S+ +C T P G C T G A L M G C N++T A T C N C +H+S+
1
V T S V F M C T P G C V T G A L M G C N L Q T A T C N C H V H I S K
34
67.6%
NZ_CP059471.1 and 3 others:
NZ_FNZW01000001.1 Lanthipeptides: BMZ61_RS02110_lanthipeptide NZ_FOYC01000001.1 Lanthipeptides: BMZ88_RS03370_lanthipeptide NZ_KE384124.1 Lanthipeptides: G597_RS0106700_lanthipeptide
Lanthipeptides: H1R75_RS06635_lanthipeptide
1
I T S I S L C T P G C K T G A L M G C N M K T A T C N C S I
30
I T S S L C T P G C K T G A L M C +K T A T C C
1
I T S K S L C T P G C K T G A L M T C P I K T A T C G C H F
30
65.7%
NZ_CP013655.1 and 2 others:
NZ_CP013655.1 Lanthipeptides: ATZ35_RS03635_lanthipeptide NZ_CP013655.1 Lanthipeptides: ATZ35_RS03630_lanthipeptide
Lanthipeptides: ATZ35_RS03640_lanthipeptide
1
I T S I S L C T P G C K T G A L M G C N M K T A T C N C S I H V S R
34
I T S S L C T P G C T G L M G C +K T T C N C S+ + +
1
I T S K S L C T P G C V T G V L M G C A L K T I T C N C S V G I G K
34
64.7%
NZ_CP024974.1 and 1 other:
NZ_JAIMDQ010000006.1 Lanthipeptides: K6V44_RS04045_lanthipeptide
Lanthipeptides: CVO91_RS06555_lanthipeptide
1
I T S I S L C T P G C K T G A L M G C N M K T A T C N C
28
+T S I S L C T P G C K T G L M C +K T A T C C
1
V T S I S L C T P G C K T G I L M T C A I K T A T C G C
28
64.7%
NZ_LR793265.1:
Lanthipeptides: HV392_RS09830_lanthipeptide
1
I T S I S L C T P G C K T G A L M G C N M K T A T C N C S I H V S R
34
I T S S L C T P G C T G L M G C ++A C N +H V S+
1
I T S Y S L C T P G C I T G V L M G C Q F Q S A G C N V H V H V S K
34

#### MIBiG 4.0 matches for PGT72_RS09560

94.1%
BGC0000535.4 (ADJ56352.1):
Lanthipeptide: nisin A
1
I T S I S L C T P G C K T G A L M G C N M K T A T C N C S I H V S R
34
I T S I S L C T P G C K T G A L M G C N M K T A T C+C S I H V S+
1
I T S I S L C T P G C K T G A L M G C N M K T A T C H C S I H V S K
34

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 16.78 out of 18.16
Confidence: strong
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.61 out of 25.88
Confidence: medium
Additional weak hits (3):
DosR
Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 19.70 out of 29.51
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 24.64 out of 35.63
Confidence: weak
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 20.28 out of 29.72
Confidence: weak
Lanthipeptides
RREFinder
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

PGT72_RS09560 - Class I
  Cleavage pHMM score: 26.70
  RODEO score: 27
  Monoisotopic mass: 3338.6 Da
  Molecular weight: 3341.0 Da
  Number of bridges: 5
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3359.0 Da N = 1
    3377.0 Da N = 2
    3395.0 Da N = 3
    3413.1 Da N = 4
PGT72_RS09560 - Class I
  Cleavage pHMM score: 26.70
  RODEO score: 27
  Monoisotopic mass: 3338.6 Da
  Molecular weight: 3341.0 Da
  Number of bridges: 5
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3359.0 Da N = 1
    3377.0 Da N = 2
    3395.0 Da N = 3
    3413.1 Da N = 4

RRE predictions
RREfinder results sidepanel.

lanthipeptide-class-i protocluster (0...25090)
PGT72_RS09555
  RRE type: Lanthipeptide_LanB_RRE
  Location: 141 - 229
  Score: 29.4

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CRP | Cyclic AMP receptor protein
PsrA | Oleic acid responsive regulator

NZ_JAQDYA010000007.1 - Region 2 - betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 26,212 - 58,744 nt. (total: 32,533 nt) Show pHMM detection rules used
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: carboxylase
PGT72_RS09640: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: ligase
PGT72_RS09675: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002116.3 |  | 0.41 | ribosomal | darobactin A | Photorhabdus khanii HGB 1456
BGC0000501.3 |  | 0.40 | ribosomal | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0001579.4 |  | 0.39 | ribosomal | duramycin | Streptomyces cinnamoneus
BGC0001391.3 |  | 0.37 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni
BGC0000412.5 |  | 0.36 | NRPS | pyochelin | Pseudomonas aeruginosa PAO1
BGC0000904.5 |  | 0.35 | other (other) | FR-900098 | Streptomyces rubellomurinus
BGC0002092.3 |  | 0.34 | NRPS | stechlisin B2, stechlisin C3, stechlisin D3, tensin, stechlisin E2, stechlisin F | Pseudomonas sp.
BGC0000497.3 |  | 0.34 | ribosomal | BHT-Aα, BHT-Aβ | Streptococcus ratti
BGC0002681.3 |  | 0.34 | other (other) | rhizoferrin | Francisella tularensis subsp. tularensis SCHU S4
BGC0002699.2 |  | 0.34 | ribosomal | nostolysamide A, nostolysamide B | Nostoc punctiforme PCC 73102

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002116.3 |  | 0.41 | ribosomal | darobactin A | Photorhabdus khanii HGB 1456
BGC0000501.3 |  | 0.40 | ribosomal | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0001579.4 |  | 0.39 | ribosomal | duramycin | Streptomyces cinnamoneus
BGC0001391.3 |  | 0.37 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni
BGC0000412.5 |  | 0.36 | NRPS | pyochelin | Pseudomonas aeruginosa PAO1
BGC0000904.5 |  | 0.35 | other (other) | FR-900098 | Streptomyces rubellomurinus
BGC0002092.3 |  | 0.34 | NRPS | stechlisin B2, stechlisin C3, stechlisin D3, tensin, stechlisin E2, stechlisin F | Pseudomonas sp.
BGC0000497.3 |  | 0.34 | ribosomal | BHT-Aα, BHT-Aβ | Streptococcus ratti
BGC0002681.3 |  | 0.34 | other (other) | rhizoferrin | Francisella tularensis subsp. tularensis SCHU S4
BGC0002699.2 |  | 0.34 | ribosomal | nostolysamide A, nostolysamide B | Nostoc punctiforme PCC 73102

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 25.74 out of 30.25
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.11 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.98 out of 27.78
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.76 out of 27.78
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.05 out of 20.97
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.90 out of 27.78
Confidence: strong
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.20 out of 26.33
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.34 out of 28.19
Confidence: medium
Additional weak hits (2):
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.59 out of 29.25
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 23.17 out of 35.63
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator
MogR | Repressor of flagellar motility genes
ZuR variant 1 | Zinc-responsive repressor