GCF_024582935.1 - 4 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP102135.1 (Streptococcus suis)

Region	Type	From	To
Region 1	lanthipeptide-class-ii	261,645	284,896
Region 2	lanthipeptide-class-iv	348,612	371,287
Region 3	terpene-precursor	1,415,809	1,436,771
Region 4	T3PKS,terpene-precursor	1,634,646	1,675,800

NZ_CP102135.1 - Region 1 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 261,645 - 284,896 nt. (total: 23,252 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

NQZ98_RS01505: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000554.4	0.56	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000504.5	0.53	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001210.5	0.51	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000558.5	0.49	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0000516.4	0.47	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000521.3	0.47	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000626.3	0.47	ribosomal	thuricin	Bacillus thuringiensis
BGC0001787.3	0.46	ribosomal	suicin 3908	Streptococcus suis
BGC0000528.5	0.46	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000552.3	0.46	ribosomal	SmbA, SmbB	Streptococcus mutans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000554.4	0.56	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000504.5	0.53	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001210.5	0.51	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000558.5	0.49	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0000516.4	0.47	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000521.3	0.47	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000626.3	0.47	ribosomal	thuricin	Bacillus thuringiensis
BGC0001787.3	0.46	ribosomal	suicin 3908	Streptococcus suis
BGC0000528.5	0.46	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000552.3	0.46	ribosomal	SmbA, SmbB	Streptococcus mutans

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for NQZ98_RS01505

NQZ98_RS01500

Leader:

MSDWKKPIYESLSTEGNPAGDILRELSESEMDQAMAGG

Core:

TARSYCGCYSGEHSCGRGCTITTECPFLTFICC

Core with dehydrations:

DhbARDhaYCysGCysYDhaGEHDhaCysGRGCysDhbIDhbDhbECysPFLDhbFICysCys

antiSMASH-DB 4.0 matches for NQZ98_RS01500

100.0%

NZ_CP102135.1:

Lanthipeptides: NQZ98_RS01500_lanthipeptide

TARSYCGCYSGEHSCGRGCTITTECPFLTFICC

97.0%

NC_011900.1and 2 others:

NZ_NCVD01000002.1 Lanthipeptides: B7702_RS00350_lanthipeptideNZ_NCVL01000015.1 Lanthipeptides: B7694_RS04515_lanthipeptide

Lanthipeptides: SPN23F_RS06435_lanthipeptide

TARSYCGCYSGEHSCGRGCTITTECPFLTFICC

TARSYC CYSGEHSCGRGCTITTECPFLTFICC

TARSYCACYSGEHSCGRGCTITTECPFLTFICC

93.9%

NZ_JVCZ01000028.1:

Lanthipeptides: ADG88_RS11420_lanthipeptide

TARSYCGCYSGEHSCGRGCTITTECPFLTFICC

TARSYC CYSGE+SCGRGCTITTECPFLTFICC

TARSYCACYSGENSCGRGCTITTECPFLTFICC

with 46 more sequence matches

Only the first 10 are displayed here.

76.5%

NZ_LR595858.1:

Lanthipeptides: FQT45_RS03330_lanthipeptide

TARSYCGCYSGEHSCGRGCTITTECPFLTFICC

TA SYC CYSG+ SCGRGCTITTECP T ICC

TANSYCHCYSGKDSCGRGCTITTECPIATIICC

72.7%

NZ_FQTY01000002.1:

Lanthipeptides: BUB33_RS04605_lanthipeptide

TARSYCGCYSGEHSCGRGCTITTECPFLTFICC

TA SYC CYS + SCG GCTITTECP T ICC

TANSYCHCYSNKDSCGHGCTITTECPVATVICC

70.6%

NZ_GG666304.1:

Lanthipeptides: HMPREF0077_RS09155_lanthipeptide

TARSYCGCYSGEHSCGRGCTITTECPFLTFICC

TA ++C CYSG+ SCG GCTITTECPF T ICC

TANTHCHCYSGKDSCGHGCTITTECPFATLICC

70.6%

NZ_JADPCZ010000011.1and 1 other:

NZ_OW659477.1 Lanthipeptides: NMG62_RS06660_lanthipeptide

Lanthipeptides: I4W03_RS06785_lanthipeptide

TARSYCGCYSGEHSCGRGCTITTECPFLTFICC

TA +YC CYSG+HSCGR CT+TTECP T ICC

TANTYCHCYSGKHSCGRACTVTTECPIATIICC

69.7%

NZ_CP040409.1and 4 others:

NZ_CP040411.1 Lanthipeptides: FE334_RS06825_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS09430_lanthipeptideNZ_JH601103.1 Lanthipeptides: HMPREF9703_RS02710_lanthipeptideNZ_NAQX01000046.1 Lanthipeptides: B8A46_RS06295_lanthipeptide

Lanthipeptides: FE336_RS08590_lanthipeptide

TARSYCGCYSGEHSCGRGCTITTECPFLTFICC

TA +YC CYSG HSCGR CTIT ECP T CC

TANTYCRCYSGRHSCGRACTITAECPVFTVACC

67.6%

NZ_JADNMH010000005.1:

Lanthipeptides: I2E99_RS07105_lanthipeptide

TARSYCGCYSGEHSCGRGCTITTECPFLTFICC

TA +YC CYSG+ SCGR CTITTECP T +CC

TANTYCHCYSGKDSCGRRCTITTECPIATVVCC

58.8%

NZ_JAESIP010000017.1and 3 others:

NZ_LT907978.1 Lanthipeptides: EHLA_RS12685_lanthipeptideNZ_QRYY01000029.1 Lanthipeptides: DWW21_RS18370_lanthipeptideNZ_SPFW01000044.1 Lanthipeptides: FGQ81_RS16590_lanthipeptide

Lanthipeptides: JMK14_RS12260_lanthipeptide

TARSYCGCYSGEHSCGRGCTITTECPFLTFICC

TA ++C CYS + SCGR CT T ECP +T ICC

TANTHCNCYSEDASCGRLCTGTAECPIMTIICC

52.9%

NZ_LMFO01000023.1:

Lanthipeptides: allorf_629531_629758_lanthipeptide

TARSYCGCYSGEHSCGRGCTITTECPFLTFIC

+ +Y CYS + SCG CT TTECPFL+F C

SPNTYNSCYSKQKSCGNFCTFTTECPFLSFCC

33.3%

NZ_AUBN01000022.1:

Lanthipeptides: G448_RS16025_lanthipeptide

SCGRGCTITTECPFLTFIC

S G CT+T EC TFIC

SSGWFCTLTIECG--TFIC

33.3%

NZ_CP048273.1and 3 others:

NZ_CP048273.1 Lanthipeptides: M654_RS18555_lanthipeptideNZ_LT745776.1 Lanthipeptides: B2C81_RS11280_lanthipeptideNZ_LT745776.1 Lanthipeptides: B2C81_RS11275_lanthipeptide

Lanthipeptides: M654_RS18560_lanthipeptide

CGRGCTITTECPFLTFICC

CG CTIT +CP F+CC

CGWACTITDDCPNSVFVCC

MIBiG 4.0 matches for NQZ98_RS01500

18.2%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

GRGCTITTEC

G CT+T EC

GAYCTLTVEC

18.2%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

GRGCTITTEC

G CT+T EC

GGWCTLTKEC

10.3%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

CTITTEC

CT++ EC

CTLSKEC

NQZ98_RS01525

Leader:

MRFSYNGLWKLLIDKGWTKSELRQKAGI

Core:

SSSTIAKLGKGENVTTDVLLRICIALDCDIEDIVEIIP

Core with dehydrations:

DhaDhaDhaDhbIAKLGKGENVDhbDhbDVLLRICysIALDCysDIEDIVEIIP

antiSMASH-DB 4.0 matches for NQZ98_RS01525

100.0%

NZ_CP102135.1:

Lanthipeptides: NQZ98_RS01525_lanthipeptide

SSSTIAKLGKGENVTTDVLLRICIALDCDIEDIVEIIP

80.0%

NZ_BLIS01000009.1and 5 others:

NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04860_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02665_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02665_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01890_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01890_lanthipeptide

Lanthipeptides: GVO03_RS04860_lanthipeptide

SSSTIAKLGKGENVTTDVLLRICIALDCDIEDIVEII

SSSTIAKLGKGENVTTD+LL+ICIALDC IEDI+EI+

SSSTIAKLGKGENVTTDILLKICIALDCKIEDIIEIV

31.6%

NZ_QUCI01000001.1:

Lanthipeptides: DW648_RS00980_lanthipeptide

SSSTIAKLGKGE-NVTTDVLLRICIALDCDIEDIV

S +T++ + G+ N T + L +CIALD E++

SRNTVSSIETGQFNPTAKLALVLCIALDKKFEELF

with 1 more sequence matches

15.0%

NZ_CP047936.1:

Lanthipeptides: allorf_0851453_0851611_lanthipeptide

ALDCDIEDIVEII

AL C + D++EI+

ALRCFVHDVIEIL

MIBiG 4.0 matches for NQZ98_RS01525

7.9%

BGC0000563.4 (AEA03263.1):

Lanthipeptide: venezuelin

ICIALDC

+CI + C

VCIGISC

NQZ98_RS01535

Leader:

MQLPNKLYSYQKSTLAYLPKVLNEIKSGNSNVKDIFHA

Core:

ISEELDDPTDFLSIMDCLYALNAIEMSNEGEVNLCL

Core with dehydrations:

IDhaEELDDPDhbDFLDhaIMDCysLYALNAIEMDhaNEGEVNLCysL

antiSMASH-DB 4.0 matches for NQZ98_RS01535

100.0%

NZ_CP102135.1:

Lanthipeptides: NQZ98_RS01535_lanthipeptide

ISEELDDPTDFLSIMDCLYALNAIEMSNEGEVNLCL

97.2%

NZ_BLIS01000009.1and 6 others:

NZ_CAAHHE010000002.1 Lanthipeptides: E9499_RS03005_lanthipeptideNZ_CAAHHN010000003.1 Lanthipeptides: E9502_RS05635_lanthipeptideNZ_CAAHRY010000002.1 Lanthipeptides: E9986_RS03100_lanthipeptideNZ_CAAIES010000002.1 Lanthipeptides: FAH15_RS02400_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02675_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01880_lanthipeptide

Lanthipeptides: GVO03_RS04870_lanthipeptide

ISEELDDPTDFLSIMDCLYALNAIEMSNEGEVNLCL

ISEELDDPTDFLSIMDCLYALNAIEMSNEGEV LCL

ISEELDDPTDFLSIMDCLYALNAIEMSNEGEVKLCL

19.4%

NZ_CAKMMP010000011.1:

Lanthipeptides: allorf_219369_219518_lanthipeptide

ISEELDDPTDFLSIMDC

I E+L + T ++S+M+C

IREDLCEQTWWVSLMNC

allorf_0266935_0267012

Leader:

MIRESLNCM

Core:

LPKTDHIECVALLVKV

Core with dehydrations:

LPKDhbDHIECysVALLVKV

antiSMASH-DB 4.0 matches for allorf_0266935_0267012

100.0%

NZ_CP102135.1:

Lanthipeptides: allorf_0266935_0267012_lanthipeptide

LPKTDHIECVALLVKV

18.9%

NZ_CP006872.1:

Lanthipeptides: allorf_5538288_5538485_lanthipeptide

KTDHIECVALLVK

KTD+ +CVA K

KTDNTKCVATCGK

16.1%

NZ_CYZG01000001.1:

Lanthipeptides: allorf_016066_016191_lanthipeptide

HIECVALLVKV

H++CVA+ V

HLQCVAVFTNV

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.70 out of 27.78

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.75 out of 29.38

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.26 out of 24.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.00 out of 26.06

Confidence: medium

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 21.54 out of 23.43

Confidence: medium

Additional weak hits (4):

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.78 out of 28.14

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.54 out of 29.25

Confidence: weak

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 20.24 out of 29.72

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

NQZ98_RS01500 - Class II

Cleavage pHMM score: -2.20

RODEO score: 0

Monoisotopic mass: 3424.4 Da

Molecular weight: 3426.9 Da

Number of bridges: 7

Alternative weights: (assuming N unmodified Ser/Thr residues); 3444.9 Da N = 1

NQZ98_RS01525 - Class II

Cleavage pHMM score: -6.60

RODEO score: 0

Monoisotopic mass: 3948.1 Da

Molecular weight: 3950.5 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3968.6 Da N = 1; 3986.6 Da N = 2; 4004.6 Da N = 3; 4022.6 Da N = 4

NQZ98_RS01535 - Class II

Cleavage pHMM score: -7.00

RODEO score: 0

Monoisotopic mass: 3946.8 Da

Molecular weight: 3949.4 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3967.4 Da N = 1; 3985.4 Da N = 2

allorf_0266935_0267012 - Class II

Cleavage pHMM score: -6.00

RODEO score: 0

Monoisotopic mass: 1759.0 Da

Molecular weight: 1760.1 Da

Number of bridges: 1

TFBS definitions

Regulator	Description
BldD	Development and antibiotic global regulator
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1	Ferric Uptake Regulator
LexA variant 2	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes

NZ_CP102135.1 - Region 2 - lanthipeptide-class-iv

Download region GenBank file

Download region SVG

Location: 348,612 - 371,287 nt. (total: 22,676 nt) Show pHMM detection rules used

lanthipeptide-class-iv: (cds(LANC_like and Pkinase) and not micKC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000519.4	0.48	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000496.5	0.45	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000553.3	0.43	ribosomal	SRO15-2212	Streptomyces filamentosus NRRL 15998
BGC0000558.5	0.43	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0001555.4	0.41	ribosomal	colicin V	Escherichia coli chi7122
BGC0002699.2	0.41	ribosomal	nostolysamide A, nostolysamide B	Nostoc punctiforme PCC 73102
BGC0000590.5	0.41	ribosomal	microcin N	Escherichia coli
BGC0001639.3	0.40	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0000486.4	0.40	ribosomal	butyrivibriocin AR10	Butyrivibrio fibrisolvens

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000519.4	0.48	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000496.5	0.45	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000553.3	0.43	ribosomal	SRO15-2212	Streptomyces filamentosus NRRL 15998
BGC0000558.5	0.43	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0001555.4	0.41	ribosomal	colicin V	Escherichia coli chi7122
BGC0002699.2	0.41	ribosomal	nostolysamide A, nostolysamide B	Nostoc punctiforme PCC 73102
BGC0000590.5	0.41	ribosomal	microcin N	Escherichia coli
BGC0001639.3	0.40	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0000486.4	0.40	ribosomal	butyrivibriocin AR10	Butyrivibrio fibrisolvens

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptides - No core peptides found.

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.23 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.98 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.11 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.62 out of 26.06

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.98 out of 20.97

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.27 out of 28.19

Confidence: medium

Additional weak hits (3):

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.38 out of 29.25

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.95 out of 31.73

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.02 out of 33.14

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

No core peptides found.

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MogR	Repressor of flagellar motility genes
ZuR variant 1	Zinc-responsive repressor

NZ_CP102135.1 - Region 3 - terpene-precursor

Download region GenBank file

Download region SVG

Location: 1,415,809 - 1,436,771 nt. (total: 20,963 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: dehydratase

NQZ98_RS07270: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

NQZ98_RS07280: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthetase

NQZ98_RS07255: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000616.4	0.39	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0001747.3	0.39	other (other)	pseudaminic acid	Tannerella forsythia
BGC0000639.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000641.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC416
BGC0000642.3	0.36	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0000638.3	0.36	terpene	carotenoid	Pantoea ananatis
BGC0000787.3	0.35	saccharide	O-antigen	Escherichia coli
BGC0001411.3	0.34	saccharide	polysaccharide B	Bacteroides fragilis
BGC0002323.2	0.34	ribosomal	nisin J	Staphylococcus capitis
BGC0001947.2	0.34	saccharide	K53 capsular polysaccharide	Acinetobacter baumannii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000616.4	0.39	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0001747.3	0.39	other (other)	pseudaminic acid	Tannerella forsythia
BGC0000639.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000641.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC416
BGC0000642.3	0.36	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0000638.3	0.36	terpene	carotenoid	Pantoea ananatis
BGC0000787.3	0.35	saccharide	O-antigen	Escherichia coli
BGC0001411.3	0.34	saccharide	polysaccharide B	Bacteroides fragilis
BGC0002323.2	0.34	ribosomal	nisin J	Staphylococcus capitis
BGC0001947.2	0.34	saccharide	K53 capsular polysaccharide	Acinetobacter baumannii

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

NQZ98_RS07255: PT_FPPS_like

Domain 1 (43 - 243): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

Additional weak hits (2):

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.98 out of 26.12

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 20.91 out of 30.22

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
ToxT	Regulator of MSHA biosynthesis

NZ_CP102135.1 - Region 4 - T3PKS,terpene-precursor

Download region GenBank file

Download region SVG

Location: 1,634,646 - 1,675,800 nt. (total: 41,155 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase reductase

NQZ98_RS08410: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

NQZ98_RS08445: hydroxymethylglutaryl-CoA reductase

smcogs: SMCOG1187: hydroxymethylglutaryl-CoA reductase

Transferases: acetyltransferase methyltransferase

NQZ98_RS08435: acetyl-CoA acetyltransferase

smcogs: SMCOG1124: acetyl-CoA acetyltransferase

NQZ98_RS08520: isoprenylcysteine carboxyl methyltransferase

smcogs: SMCOG1150: isoprenylcysteine carboxyl methyltransferase

Hydrolases: deacetylase

NQZ98_RS08420: polysaccharide deacetylase

smcogs: SMCOG1235: polysaccharide deacetylase

Isomerases: mutase

NQZ98_RS08430: phosphoglycerate mutase

smcogs: SMCOG1101: phosphoglycerate mutase

Ligases: synthase synthetase

NQZ98_RS08440: hydroxymethylglutaryl-CoA synthase

smcogs: SMCOG1043: hydroxymethylglutaryl-CoA synthase

NQZ98_RS08500: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.38	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.33	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.26	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0001605.3	0.25	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0000550.3	0.24	ribosomal	salivaricin G32	Streptococcus salivarius
BGC0001456.3	0.23	terpene	isorenieratene	Streptomyces argillaceus
BGC0000665.5	0.23	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0000668.5	0.22	other (other), terpene	12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole	Hapalosiphon welwitschii UTEX B 1830
BGC0000043.5	0.21	PKS	curacin A	Moorea producens 19L
BGC0000547.5	0.21	ribosomal	salivaricin 9	Streptococcus salivarius

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.54	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.51	terpene	boleracene	Brassica oleracea var. oleracea
BGC0000866.5	0.48	other (other)	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0000867.3	0.46	other (other)	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0002398.2	0.44	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000205.3	0.44	PKS	bryostatin	Candidatus Endobugula sertula
BGC0000278.3	0.43	PKS	urdamycin	Streptomyces fradiae
BGC0001605.3	0.43	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0002561.3	0.42	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0000668.5	0.41	other (other), terpene	12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole	Hapalosiphon welwitschii UTEX B 1830

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

NQZ98_RS08500: PT_FPPS_like

Domain 1 (25 - 281): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.45 out of 26.06

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.26 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.64 out of 26.06

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.95 out of 28.19

Confidence: medium

Additional weak hits (4):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.22 out of 30.25

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.38 out of 29.25

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.36 out of 36.54

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 23.31 out of 35.63

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MogR	Repressor of flagellar motility genes
ZuR variant 1	Zinc-responsive repressor