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Overview
1.1
1.2
1.3
1.4

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP102135.1 (Streptococcus suis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1 | lanthipeptide-class-ii | 261,645 | 284,896 |
Region 2 | lanthipeptide-class-iv | 348,612 | 371,287 |
Region 3 | terpene-precursor | 1,415,809 | 1,436,771 |  |
Region 4 | T3PKS,terpene-precursor | 1,634,646 | 1,675,800 |

NZ_CP102135.1 - Region 1 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 261,645 - 284,896 nt. (total: 23,252 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: cyclase
NQZ98_RS01505: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000554.4 |  | 0.56 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000504.5 |  | 0.53 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0001210.5 |  | 0.51 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000558.5 |  | 0.49 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000516.4 |  | 0.47 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000521.3 |  | 0.47 | ribosomal | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0000626.3 |  | 0.47 | ribosomal | thuricin | Bacillus thuringiensis
BGC0001787.3 |  | 0.46 | ribosomal | suicin 3908 | Streptococcus suis
BGC0000528.5 |  | 0.46 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000552.3 |  | 0.46 | ribosomal | SmbA, SmbB | Streptococcus mutans

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000554.4 |  | 0.56 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000504.5 |  | 0.53 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0001210.5 |  | 0.51 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000558.5 |  | 0.49 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000516.4 |  | 0.47 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000521.3 |  | 0.47 | ribosomal | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0000626.3 |  | 0.47 | ribosomal | thuricin | Bacillus thuringiensis
BGC0001787.3 |  | 0.46 | ribosomal | suicin 3908 | Streptococcus suis
BGC0000528.5 |  | 0.46 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000552.3 |  | 0.46 | ribosomal | SmbA, SmbB | Streptococcus mutans

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for NQZ98_RS01505

NQZ98_RS01500
Leader:
MSDWKKPIYESLSTEGNPAGDILRELSESEMDQAMAGG
Core:
T A R S Y C G C Y S G E H S C G R G C T I T T E C P F L T F I C C
Core with dehydrations:
Dhb A R Dha Y Cys G Cys Y Dha G E H Dha Cys G R G Cys Dhb I Dhb Dhb E Cys P F L Dhb F I Cys Cys

#### antiSMASH-DB 4.0 matches for NQZ98_RS01500

100.0%
NZ_CP102135.1:
Lanthipeptides: NQZ98_RS01500_lanthipeptide
1
T A R S Y C G C Y S G E H S C G R G C T I T T E C P F L T F I C C
33
T A R S Y C G C Y S G E H S C G R G C T I T T E C P F L T F I C C
1
T A R S Y C G C Y S G E H S C G R G C T I T T E C P F L T F I C C
33
97.0%
NC_011900.1 and 2 others:
NZ_NCVD01000002.1 Lanthipeptides: B7702_RS00350_lanthipeptide NZ_NCVL01000015.1 Lanthipeptides: B7694_RS04515_lanthipeptide
Lanthipeptides: SPN23F_RS06435_lanthipeptide
1
T A R S Y C G C Y S G E H S C G R G C T I T T E C P F L T F I C C
33
T A R S Y C C Y S G E H S C G R G C T I T T E C P F L T F I C C
1
T A R S Y C A C Y S G E H S C G R G C T I T T E C P F L T F I C C
33
93.9%
NZ_JVCZ01000028.1:
Lanthipeptides: ADG88_RS11420_lanthipeptide
1
T A R S Y C G C Y S G E H S C G R G C T I T T E C P F L T F I C C
33
T A R S Y C C Y S G E+S C G R G C T I T T E C P F L T F I C C
1
T A R S Y C A C Y S G E N S C G R G C T I T T E C P F L T F I C C
33
with 46 more sequence matches
Only the first 10 are displayed here.
76.5%
NZ_LR595858.1:
Lanthipeptides: FQT45_RS03330_lanthipeptide
1
T A R S Y C G C Y S G E H S C G R G C T I T T E C P F L T F I C C
33
T A S Y C C Y S G+ S C G R G C T I T T E C P T I C C
2
T A N S Y C H C Y S G K D S C G R G C T I T T E C P I A T I I C C
34
72.7%
NZ_FQTY01000002.1:
Lanthipeptides: BUB33_RS04605_lanthipeptide
1
T A R S Y C G C Y S G E H S C G R G C T I T T E C P F L T F I C C
33
T A S Y C C Y S + S C G G C T I T T E C P T I C C
1
T A N S Y C H C Y S N K D S C G H G C T I T T E C P V A T V I C C
33
70.6%
NZ_GG666304.1:
Lanthipeptides: HMPREF0077_RS09155_lanthipeptide
1
T A R S Y C G C Y S G E H S C G R G C T I T T E C P F L T F I C C
33
T A ++C C Y S G+ S C G G C T I T T E C P F T I C C
2
T A N T H C H C Y S G K D S C G H G C T I T T E C P F A T L I C C
34
70.6%
NZ_JADPCZ010000011.1 and 1 other:
NZ_OW659477.1 Lanthipeptides: NMG62_RS06660_lanthipeptide
Lanthipeptides: I4W03_RS06785_lanthipeptide
1
T A R S Y C G C Y S G E H S C G R G C T I T T E C P F L T F I C C
33
T A +Y C C Y S G+H S C G R C T+T T E C P T I C C
2
T A N T Y C H C Y S G K H S C G R A C T V T T E C P I A T I I C C
34
69.7%
NZ_CP040409.1 and 4 others:
NZ_CP040411.1 Lanthipeptides: FE334_RS06825_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS09430_lanthipeptide NZ_JH601103.1 Lanthipeptides: HMPREF9703_RS02710_lanthipeptide NZ_NAQX01000046.1 Lanthipeptides: B8A46_RS06295_lanthipeptide
Lanthipeptides: FE336_RS08590_lanthipeptide
1
T A R S Y C G C Y S G E H S C G R G C T I T T E C P F L T F I C C
33
T A +Y C C Y S G H S C G R C T I T E C P T C C
1
T A N T Y C R C Y S G R H S C G R A C T I T A E C P V F T V A C C
33
67.6%
NZ_JADNMH010000005.1:
Lanthipeptides: I2E99_RS07105_lanthipeptide
1
T A R S Y C G C Y S G E H S C G R G C T I T T E C P F L T F I C C
33
T A +Y C C Y S G+ S C G R C T I T T E C P T +C C
2
T A N T Y C H C Y S G K D S C G R R C T I T T E C P I A T V V C C
34
58.8%
NZ_JAESIP010000017.1 and 3 others:
NZ_LT907978.1 Lanthipeptides: EHLA_RS12685_lanthipeptide NZ_QRYY01000029.1 Lanthipeptides: DWW21_RS18370_lanthipeptide NZ_SPFW01000044.1 Lanthipeptides: FGQ81_RS16590_lanthipeptide
Lanthipeptides: JMK14_RS12260_lanthipeptide
1
T A R S Y C G C Y S G E H S C G R G C T I T T E C P F L T F I C C
33
T A ++C C Y S + S C G R C T T E C P +T I C C
2
T A N T H C N C Y S E D A S C G R L C T G T A E C P I M T I I C C
34
52.9%
NZ_LMFO01000023.1:
Lanthipeptides: allorf_629531_629758_lanthipeptide
1
T A R S Y C G C Y S G E H S C G R G C T I T T E C P F L T F I C
32
+ +Y C Y S + S C G C T T T E C P F L+F C
3
S P N T Y N S C Y S K Q K S C G N F C T F T T E C P F L S F C C
34
33.3%
NZ_AUBN01000022.1:
Lanthipeptides: G448_RS16025_lanthipeptide
14
S C G R G C T I T T E C P F L T F I C
32
S G C T+T E C T F I C
2
S S G W F C T L T I E C G--T F I C
18
33.3%
NZ_CP048273.1 and 3 others:
NZ_CP048273.1 Lanthipeptides: M654_RS18555_lanthipeptide NZ_LT745776.1 Lanthipeptides: B2C81_RS11280_lanthipeptide NZ_LT745776.1 Lanthipeptides: B2C81_RS11275_lanthipeptide
Lanthipeptides: M654_RS18560_lanthipeptide
15
C G R G C T I T T E C P F L T F I C C
33
C G C T I T +C P F+C C
3
C G W A C T I T D D C P N S V F V C C
21

#### MIBiG 4.0 matches for NQZ98_RS01500

18.2%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
16
G R G C T I T T E C
25
G C T+T E C
14
G A Y C T L T V E C
23
18.2%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
16
G R G C T I T T E C
25
G C T+T E C
16
G G W C T L T K E C
25
10.3%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
19
C T I T T E C
25
C T++ E C
28
C T L S K E C
34
NQZ98_RS01525
Leader:
MRFSYNGLWKLLIDKGWTKSELRQKAGI
Core:
S S S T I A K L G K G E N V T T D V L L R I C I A L D C D I E D I V E I I P
Core with dehydrations:
Dha Dha Dha Dhb I A K L G K G E N V Dhb Dhb D V L L R I Cys I A L D Cys D I E D I V E I I P

#### antiSMASH-DB 4.0 matches for NQZ98_RS01525

100.0%
NZ_CP102135.1:
Lanthipeptides: NQZ98_RS01525_lanthipeptide
1
S S S T I A K L G K G E N V T T D V L L R I C I A L D C D I E D I V E I I P
38
S S S T I A K L G K G E N V T T D V L L R I C I A L D C D I E D I V E I I P
1
S S S T I A K L G K G E N V T T D V L L R I C I A L D C D I E D I V E I I P
38
80.0%
NZ_BLIS01000009.1 and 5 others:
NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04860_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02665_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02665_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01890_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01890_lanthipeptide
Lanthipeptides: GVO03_RS04860_lanthipeptide
1
S S S T I A K L G K G E N V T T D V L L R I C I A L D C D I E D I V E I I
37
S S S T I A K L G K G E N V T T D+L L+I C I A L D C I E D I+E I+
1
S S S T I A K L G K G E N V T T D I L L K I C I A L D C K I E D I I E I V
37
31.6%
NZ_QUCI01000001.1:
Lanthipeptides: DW648_RS00980_lanthipeptide
1
S S S T I A K L G K G E-N V T T D V L L R I C I A L D C D I E D I V
34
S +T++ + G+ N T + L +C I A L D E++
1
S R N T V S S I E T G Q F N P T A K L A L V L C I A L D K K F E E L F
35
with 1 more sequence matches
15.0%
NZ_CP047936.1:
Lanthipeptides: allorf_0851453_0851611_lanthipeptide
25
A L D C D I E D I V E I I
37
A L C + D++E I+
9
A L R C F V H D V I E I L
21

#### MIBiG 4.0 matches for NQZ98_RS01525

7.9%
BGC0000563.4 (AEA03263.1):
Lanthipeptide: venezuelin
22
I C I A L D C
28
+C I + C
15
V C I G I S C
21
NQZ98_RS01535
Leader:
MQLPNKLYSYQKSTLAYLPKVLNEIKSGNSNVKDIFHA
Core:
I S E E L D D P T D F L S I M D C L Y A L N A I E M S N E G E V N L C L
Core with dehydrations:
I Dha E E L D D P Dhb D F L Dha I M D Cys L Y A L N A I E M Dha N E G E V N L Cys L

#### antiSMASH-DB 4.0 matches for NQZ98_RS01535

100.0%
NZ_CP102135.1:
Lanthipeptides: NQZ98_RS01535_lanthipeptide
1
I S E E L D D P T D F L S I M D C L Y A L N A I E M S N E G E V N L C L
36
I S E E L D D P T D F L S I M D C L Y A L N A I E M S N E G E V N L C L
1
I S E E L D D P T D F L S I M D C L Y A L N A I E M S N E G E V N L C L
36
97.2%
NZ_BLIS01000009.1 and 6 others:
NZ_CAAHHE010000002.1 Lanthipeptides: E9499_RS03005_lanthipeptide NZ_CAAHHN010000003.1 Lanthipeptides: E9502_RS05635_lanthipeptide NZ_CAAHRY010000002.1 Lanthipeptides: E9986_RS03100_lanthipeptide NZ_CAAIES010000002.1 Lanthipeptides: FAH15_RS02400_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02675_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01880_lanthipeptide
Lanthipeptides: GVO03_RS04870_lanthipeptide
1
I S E E L D D P T D F L S I M D C L Y A L N A I E M S N E G E V N L C L
36
I S E E L D D P T D F L S I M D C L Y A L N A I E M S N E G E V L C L
1
I S E E L D D P T D F L S I M D C L Y A L N A I E M S N E G E V K L C L
36
19.4%
NZ_CAKMMP010000011.1:
Lanthipeptides: allorf_219369_219518_lanthipeptide
1
I S E E L D D P T D F L S I M D C
17
I E+L + T ++S+M+C
10
I R E D L C E Q T W W V S L M N C
26
allorf_0266935_0267012
Leader:
MIRESLNCM
Core:
L P K T D H I E C V A L L V K V
Core with dehydrations:
L P K Dhb D H I E Cys V A L L V K V

#### antiSMASH-DB 4.0 matches for allorf_0266935_0267012

100.0%
NZ_CP102135.1:
Lanthipeptides: allorf_0266935_0267012_lanthipeptide
1
L P K T D H I E C V A L L V K V
16
L P K T D H I E C V A L L V K V
1
L P K T D H I E C V A L L V K V
16
18.9%
NZ_CP006872.1:
Lanthipeptides: allorf_5538288_5538485_lanthipeptide
3
K T D H I E C V A L L V K
15
K T D+ +C V A K
15
K T D N T K C V A T C G K
27
16.1%
NZ_CYZG01000001.1:
Lanthipeptides: allorf_016066_016191_lanthipeptide
6
H I E C V A L L V K V
16
H++C V A+ V
8
H L Q C V A V F T N V
18

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.70 out of 27.78
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.75 out of 29.38
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.26 out of 24.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.00 out of 26.06
Confidence: medium
BldD
Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 21.54 out of 23.43
Confidence: medium
Additional weak hits (4):
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.78 out of 28.14
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.54 out of 29.25
Confidence: weak
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 20.24 out of 29.72
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

NQZ98_RS01500 - Class II
  Cleavage pHMM score: -2.20
  RODEO score: 0
  Monoisotopic mass: 3424.4 Da
  Molecular weight: 3426.9 Da
  Number of bridges: 7
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3444.9 Da N = 1
NQZ98_RS01525 - Class II
  Cleavage pHMM score: -6.60
  RODEO score: 0
  Monoisotopic mass: 3948.1 Da
  Molecular weight: 3950.5 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3968.6 Da N = 1
    3986.6 Da N = 2
    4004.6 Da N = 3
    4022.6 Da N = 4
NQZ98_RS01535 - Class II
  Cleavage pHMM score: -7.00
  RODEO score: 0
  Monoisotopic mass: 3946.8 Da
  Molecular weight: 3949.4 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3967.4 Da N = 1
    3985.4 Da N = 2
allorf_0266935_0267012 - Class II
  Cleavage pHMM score: -6.00
  RODEO score: 0
  Monoisotopic mass: 1759.0 Da
  Molecular weight: 1760.1 Da
  Number of bridges: 1

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
BldD | Development and antibiotic global regulator
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1 | Ferric Uptake Regulator
LexA variant 2 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes

NZ_CP102135.1 - Region 2 - lanthipeptide-class-iv
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 348,612 - 371,287 nt. (total: 22,676 nt) Show pHMM detection rules used
lanthipeptide-class-iv: (cds(LANC_like and Pkinase) and not micKC)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
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Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-iv | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000519.4 |  | 0.48 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000496.5 |  | 0.45 | ribosomal | AmfS | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000553.3 |  | 0.43 | ribosomal | SRO15-2212 | Streptomyces filamentosus NRRL 15998
BGC0000558.5 |  | 0.43 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0001555.4 |  | 0.41 | ribosomal | colicin V | Escherichia coli chi7122
BGC0002699.2 |  | 0.41 | ribosomal | nostolysamide A, nostolysamide B | Nostoc punctiforme PCC 73102
BGC0000590.5 |  | 0.41 | ribosomal | microcin N | Escherichia coli
BGC0001639.3 |  | 0.40 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0000486.4 |  | 0.40 | ribosomal | butyrivibriocin AR10 | Butyrivibrio fibrisolvens

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000519.4 |  | 0.48 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000496.5 |  | 0.45 | ribosomal | AmfS | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000553.3 |  | 0.43 | ribosomal | SRO15-2212 | Streptomyces filamentosus NRRL 15998
BGC0000558.5 |  | 0.43 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0001555.4 |  | 0.41 | ribosomal | colicin V | Escherichia coli chi7122
BGC0002699.2 |  | 0.41 | ribosomal | nostolysamide A, nostolysamide B | Nostoc punctiforme PCC 73102
BGC0000590.5 |  | 0.41 | ribosomal | microcin N | Escherichia coli
BGC0001639.3 |  | 0.40 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0000486.4 |  | 0.40 | ribosomal | butyrivibriocin AR10 | Butyrivibrio fibrisolvens

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.
Lanthipeptides - No core peptides found.
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.23 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.98 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.11 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.62 out of 26.06
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.98 out of 20.97
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.27 out of 28.19
Confidence: medium
Additional weak hits (3):
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.38 out of 29.25
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.95 out of 31.73
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.02 out of 33.14
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.
No core peptides found.
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MogR | Repressor of flagellar motility genes
ZuR variant 1 | Zinc-responsive repressor

NZ_CP102135.1 - Region 3 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,415,809 - 1,436,771 nt. (total: 20,963 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: dehydratase
NQZ98_RS07270: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

NQZ98_RS07280: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthetase
NQZ98_RS07255: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000616.4 |  | 0.39 | ribosomal | amylocyclicin | Bacillus velezensis FZB42
BGC0001747.3 |  | 0.39 | other (other) | pseudaminic acid | Tannerella forsythia
BGC0000639.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000641.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC416
BGC0000642.3 |  | 0.36 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0000638.3 |  | 0.36 | terpene | carotenoid | Pantoea ananatis
BGC0000787.3 |  | 0.35 | saccharide | O-antigen | Escherichia coli
BGC0001411.3 |  | 0.34 | saccharide | polysaccharide B | Bacteroides fragilis
BGC0002323.2 |  | 0.34 | ribosomal | nisin J | Staphylococcus capitis
BGC0001947.2 |  | 0.34 | saccharide | K53 capsular polysaccharide | Acinetobacter baumannii

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000616.4 |  | 0.39 | ribosomal | amylocyclicin | Bacillus velezensis FZB42
BGC0001747.3 |  | 0.39 | other (other) | pseudaminic acid | Tannerella forsythia
BGC0000639.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000641.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC416
BGC0000642.3 |  | 0.36 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0000638.3 |  | 0.36 | terpene | carotenoid | Pantoea ananatis
BGC0000787.3 |  | 0.35 | saccharide | O-antigen | Escherichia coli
BGC0001411.3 |  | 0.34 | saccharide | polysaccharide B | Bacteroides fragilis
BGC0002323.2 |  | 0.34 | ribosomal | nisin J | Staphylococcus capitis
BGC0001947.2 |  | 0.34 | saccharide | K53 capsular polysaccharide | Acinetobacter baumannii

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP
diterpene precursor |  | GGPP | C20 | acyclic | PP
sesterterpene precursor |  | GFPP | C25 | acyclic | PP
triterpene precursor |  | HPP | C30 | acyclic | PP

Genes with terpene domains:
NQZ98_RS07255: PT_FPPS_like
Domain 1 (43 - 243): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: unknown

Reactions:
  IPP, DMAPP → FPP
  IPP, DMAPP → GGPP
  IPP, DMAPP → GFPP
  IPP, DMAPP → HPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
Additional weak hits (2):
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.98 out of 26.12
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 20.91 out of 30.22
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
GFPP | Geranylfarnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
HPP | Hexaprenyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ToxT | Regulator of MSHA biosynthesis

NZ_CP102135.1 - Region 4 - T3PKS,terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,634,646 - 1,675,800 nt. (total: 41,155 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase reductase
NQZ98_RS08410: oxidoreductase

smcogs
  SMCOG1079: oxidoreductase

NQZ98_RS08445: hydroxymethylglutaryl-CoA reductase

smcogs
  SMCOG1187: hydroxymethylglutaryl-CoA reductase

Transferases: acetyltransferase methyltransferase
NQZ98_RS08435: acetyl-CoA acetyltransferase

smcogs
  SMCOG1124: acetyl-CoA acetyltransferase

NQZ98_RS08520: isoprenylcysteine carboxyl methyltransferase

smcogs
  SMCOG1150: isoprenylcysteine carboxyl methyltransferase

Hydrolases: deacetylase
NQZ98_RS08420: polysaccharide deacetylase

smcogs
  SMCOG1235: polysaccharide deacetylase

Isomerases: mutase
NQZ98_RS08430: phosphoglycerate mutase

smcogs
  SMCOG1101: phosphoglycerate mutase

Ligases: synthase synthetase
NQZ98_RS08440: hydroxymethylglutaryl-CoA synthase

smcogs
  SMCOG1043: hydroxymethylglutaryl-CoA synthase

NQZ98_RS08500: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0002397.2 |  |  | 0.38 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  |  | 0.33 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  |  | 0.26 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0001605.3 |  |  | 0.25 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0000550.3 |  |  | 0.24 | ribosomal | salivaricin G32 | Streptococcus salivarius
BGC0001456.3 |  |  | 0.23 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000665.5 |  |  | 0.23 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0000668.5 |  |  | 0.22 | other (other), terpene | 12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole | Hapalosiphon welwitschii UTEX B 1830
BGC0000043.5 |  |  | 0.21 | PKS | curacin A | Moorea producens 19L
BGC0000547.5 |  |  | 0.21 | ribosomal | salivaricin 9 | Streptococcus salivarius

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.54 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.51 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0000866.5 |  | 0.48 | other (other) | polyhydroxyalkanoate | Burkholderia sp. DSM 9242
BGC0000867.3 |  | 0.46 | other (other) | polyhydroxyalkanoic acids | Ectothiorhodospira shaposhnikovii
BGC0002398.2 |  | 0.44 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0000205.3 |  | 0.44 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0000278.3 |  | 0.43 | PKS | urdamycin | Streptomyces fradiae
BGC0001605.3 |  | 0.43 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0002561.3 |  | 0.42 | other (other) | phenazine SA, phenazine SB, phenazine SC | Streptomyces sp.
BGC0000668.5 |  | 0.41 | other (other), terpene | 12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole | Hapalosiphon welwitschii UTEX B 1830

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
NQZ98_RS08500: PT_FPPS_like
Domain 1 (25 - 281): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  DMAPP, IPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.45 out of 26.06
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.26 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.64 out of 26.06
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.95 out of 28.19
Confidence: medium
Additional weak hits (4):
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.22 out of 30.25
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.38 out of 29.25
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.36 out of 36.54
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 23.31 out of 35.63
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MogR | Repressor of flagellar motility genes
ZuR variant 1 | Zinc-responsive repressor