GCF_023757615.1 - 20 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_JAJNPN010000053.1 (Bacillus amyloliquefaciens)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	RiPP-like	1	6,569

NZ_JAJNPN010000001.1 (Bacillus amyloliquefaciens)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 7.1	lanthipeptide-class-ii	94,100	122,989
Region 7.2	NRPS,transAT-PKS,T3PKS	145,967	263,908	Low	bacillaene	NRPS:Type I+PKS:Type I
Region 7.3	terpene	331,507	352,247

NZ_JAJNPN010000010.1 (Bacillus amyloliquefaciens)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 8.1	terpene	161,652	183,535

NZ_JAJNPN010000012.1 (Bacillus amyloliquefaciens)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 10.1	NRPS	88,938	116,911	Low	surfactin	NRPS:Type I

NZ_JAJNPN010000013.1 (Bacillus amyloliquefaciens)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 11.1	other	112,211	153,629	High	bacilysin	other:other

NZ_JAJNPN010000015.1 (Bacillus amyloliquefaciens)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 13.1	lanthipeptide-class-ii	93,026	116,214	High	mersacidin	ribosomal:RiPP:Lanthipeptide

NZ_JAJNPN010000017.1 (Bacillus amyloliquefaciens)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 15.1	NRPS,betalactone,transAT-PKS	1	87,702	High	fengycin	NRPS:Type I

NZ_JAJNPN010000018.1 (Bacillus amyloliquefaciens)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 16.1	transAT-PKS	1	80,922	High	difficidin	PKS

NZ_JAJNPN010000002.1 (Bacillus amyloliquefaciens)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 18.1	PKS-like	1	39,591

NZ_JAJNPN010000021.1 (Bacillus amyloliquefaciens)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 20.1	HR-T2PKS	1	29,526

NZ_JAJNPN010000024.1 (Bacillus amyloliquefaciens)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 23.1	terpene-precursor	49,345	70,235

NZ_JAJNPN010000003.1 (Bacillus amyloliquefaciens)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 29.1	NRP-metallophore,NRPS,RiPP-like	32,786	84,578	High	bacillibactin	NRPS:Type I

NZ_JAJNPN010000043.1 (Bacillus amyloliquefaciens)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 43.1	NRPS	1	10,260

NZ_JAJNPN010000045.1 (Bacillus amyloliquefaciens)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 44.1	NRPS	1	8,995

NZ_JAJNPN010000005.1 (Bacillus amyloliquefaciens)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 46.1	transAT-PKS	57,645	145,875	High	macrolactin H	PKS
Region 46.2	transAT-PKS,T3PKS,NRPS	368,599	405,834	Medium	bacillaene	NRPS:Type I+PKS:Type I

NZ_JAJNPN010000006.1 (Bacillus amyloliquefaciens)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 51.1	transAT-PKS-like,NRPS	1	67,732	Low	bacillaene	NRPS:Type I+PKS:Type I

NZ_JAJNPN010000009.1 (Bacillus amyloliquefaciens)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 54.1	NRPS	185,851	211,054	Low	surfactin	NRPS:Type I

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	RiPP-like	1	6,569
Region 7.1	lanthipeptide-class-ii	94,100	122,989
Region 7.2	NRPS,transAT-PKS,T3PKS	145,967	263,908	Low	bacillaene	NRPS:Type I+PKS:Type I
Region 7.3	terpene	331,507	352,247
Region 8.1	terpene	161,652	183,535
Region 10.1	NRPS	88,938	116,911	Low	surfactin	NRPS:Type I
Region 11.1	other	112,211	153,629	High	bacilysin	other:other
Region 13.1	lanthipeptide-class-ii	93,026	116,214	High	mersacidin	ribosomal:RiPP:Lanthipeptide
Region 15.1	NRPS,betalactone,transAT-PKS	1	87,702	High	fengycin	NRPS:Type I
Region 16.1	transAT-PKS	1	80,922	High	difficidin	PKS
Region 18.1	PKS-like	1	39,591
Region 20.1	HR-T2PKS	1	29,526
Region 23.1	terpene-precursor	49,345	70,235
Region 29.1	NRP-metallophore,NRPS,RiPP-like	32,786	84,578	High	bacillibactin	NRPS:Type I
Region 43.1	NRPS	1	10,260
Region 44.1	NRPS	1	8,995
Region 46.1	transAT-PKS	57,645	145,875	High	macrolactin H	PKS
Region 46.2	transAT-PKS,T3PKS,NRPS	368,599	405,834	Medium	bacillaene	NRPS:Type I+PKS:Type I
Region 51.1	transAT-PKS-like,NRPS	1	67,732	Low	bacillaene	NRPS:Type I+PKS:Type I
Region 54.1	NRPS	185,851	211,054	Low	surfactin	NRPS:Type I

No secondary metabolite regions were found in these records:: NZ_JAJNPN010000054.1 (Bacillus amyloliquefaciens); NZ_JAJNPN010000055.1 (Bacillus amyloliquefaciens); NZ_JAJNPN010000056.1 (Bacillus amyloliquefaciens); NZ_JAJNPN010000058.1 (Bacillus amyloliquefaciens); NZ_JAJNPN010000059.1 (Bacillus amyloliquefaciens); NZ_JAJNPN010000011.1 (Bacillus amyloliquefaciens); NZ_JAJNPN010000014.1 (Bacillus amyloliquefaciens); NZ_JAJNPN010000016.1 (Bacillus amyloliquefaciens); NZ_JAJNPN010000019.1 (Bacillus amyloliquefaciens); NZ_JAJNPN010000020.1 (Bacillus amyloliquefaciens); NZ_JAJNPN010000022.1 (Bacillus amyloliquefaciens); NZ_JAJNPN010000023.1 (Bacillus amyloliquefaciens); NZ_JAJNPN010000025.1 (Bacillus amyloliquefaciens); NZ_JAJNPN010000026.1 (Bacillus amyloliquefaciens); NZ_JAJNPN010000027.1 (Bacillus amyloliquefaciens); NZ_JAJNPN010000028.1 (Bacillus amyloliquefaciens); NZ_JAJNPN010000029.1 (Bacillus amyloliquefaciens); NZ_JAJNPN010000030.1 (Bacillus amyloliquefaciens); NZ_JAJNPN010000031.1 (Bacillus amyloliquefaciens); NZ_JAJNPN010000032.1 (Bacillus amyloliquefaciens); NZ_JAJNPN010000033.1 (Bacillus amyloliquefaciens); NZ_JAJNPN010000034.1 (Bacillus amyloliquefaciens); NZ_JAJNPN010000035.1 (Bacillus amyloliquefaciens); NZ_JAJNPN010000036.1 (Bacillus amyloliquefaciens); NZ_JAJNPN010000037.1 (Bacillus amyloliquefaciens); NZ_JAJNPN010000038.1 (Bacillus amyloliquefaciens); NZ_JAJNPN010000039.1 (Bacillus amyloliquefaciens); NZ_JAJNPN010000004.1 (Bacillus amyloliquefaciens); NZ_JAJNPN010000040.1 (Bacillus amyloliquefaciens); NZ_JAJNPN010000042.1 (Bacillus amyloliquefaciens); NZ_JAJNPN010000046.1 (Bacillus amyloliquefaciens); NZ_JAJNPN010000048.1 (Bacillus amyloliquefaciens); NZ_JAJNPN010000049.1 (Bacillus amyloliquefaciens); NZ_JAJNPN010000051.1 (Bacillus amyloliquefaciens); NZ_JAJNPN010000052.1 (Bacillus amyloliquefaciens); NZ_JAJNPN010000007.1 (Bacillus amyloliquefaciens); NZ_JAJNPN010000008.1 (Bacillus amyloliquefaciens)

Compact view

NZ_JAJNPN010000053.1 - Region 1 - RiPP-like

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Location: 1 - 6,569 nt. (total: 6,569 nt) Show pHMM detection rules used

Region on contig edge.

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000617.5	0.50	ribosomal	coagulin	Bacillus coagulans
BGC0002579.2	0.49	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0000558.5	0.49	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0000624.3	0.47	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0000619.3	0.46	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001602.3	0.46	ribosomal	gassericin-T	Lactobacillus gasseri
BGC0001388.3	0.46	ribosomal	gassericin E	Lactobacillus gasseri
BGC0002577.2	0.44	ribosomal	lactococcin G	Lactococcus lactis
BGC0001862.4	0.41	ribosomal	pallidocin	Aeribacillus pallidus
BGC0002674.2	0.40	ribosomal	enterocin F4-9	Enterococcus faecalis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000617.5	0.50	ribosomal	coagulin	Bacillus coagulans
BGC0002579.2	0.49	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0000558.5	0.49	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0000624.3	0.47	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0000619.3	0.46	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001602.3	0.46	ribosomal	gassericin-T	Lactobacillus gasseri
BGC0001388.3	0.46	ribosomal	gassericin E	Lactobacillus gasseri
BGC0002577.2	0.44	ribosomal	lactococcin G	Lactococcus lactis
BGC0001862.4	0.41	ribosomal	pallidocin	Aeribacillus pallidus
BGC0002674.2	0.40	ribosomal	enterocin F4-9	Enterococcus faecalis

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (3):

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.53 out of 33.73

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 24.12 out of 36.53

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.37 out of 30.98

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description

NZ_JAJNPN010000001.1 - Region 1 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 94,100 - 122,989 nt. (total: 28,890 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

LQ568_RS00585: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

LQ568_RS00605: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000554.4	0.56	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000516.4	0.53	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000626.3	0.52	ribosomal	thuricin	Bacillus thuringiensis
BGC0000528.5	0.51	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001555.4	0.51	ribosomal	colicin V	Escherichia coli chi7122
BGC0001210.5	0.51	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000590.5	0.50	ribosomal	microcin N	Escherichia coli
BGC0001311.5	0.50	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0000539.5	0.50	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0000527.5	0.49	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000554.4	0.56	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000516.4	0.53	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000626.3	0.52	ribosomal	thuricin	Bacillus thuringiensis
BGC0000528.5	0.51	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001555.4	0.51	ribosomal	colicin V	Escherichia coli chi7122
BGC0001210.5	0.51	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000590.5	0.50	ribosomal	microcin N	Escherichia coli
BGC0001311.5	0.50	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0000539.5	0.50	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0000527.5	0.49	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for LQ568_RS00585

LQ568_RS00520

Leader:

MCKLCGPKKVIVTETGFGA

Core:

VFHPCPNCKTGTDLTPVIKRLERMVQDAKVRLDARVQIY

Core with dehydrations:

VFHPCysPNCysKDhbGDhbDLDhbPVIKRLERMVQDAKVRLDARVQIY

antiSMASH-DB 4.0 matches for LQ568_RS00520

100.0%

NZ_CP023075.1and 7 others:

NZ_CP035393.1 Lanthipeptides: ES966_RS21105_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19665_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17705_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03370_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01895_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00520_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122700_lanthipeptide

Lanthipeptides: CK238_RS20695_lanthipeptide

1

VFHPCPNCKTGTDLTPVIKRLERMVQDAKVRLDARVQIY

39

VFHPCPNCKTGTDLTPVIKRLERMVQDAKVRLDARVQIY

1

VFHPCPNCKTGTDLTPVIKRLERMVQDAKVRLDARVQIY

39

92.3%

NZ_CP044444.1:

Lanthipeptides: F7V86_RS20970_lanthipeptide

1

VFHPCPNCKTGTDLTPVIKRLERMVQDAKVRLDARV

36

VFHPCPNCKTGTDLTPVIKRLERMVQDAKVRLDARV

1

VFHPCPNCKTGTDLTPVIKRLERMVQDAKVRLDARV

36

89.7%

NC_023073.1and 25 others:

NZ_CP010556.1 Lanthipeptides: SB45_RS19805_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19795_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20400_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22075_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS21000_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21480_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19740_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19585_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20470_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21110_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20035_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16480_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06705_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18975_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06485_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16830_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06200_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12895_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06150_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06335_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11720_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS03045_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19745_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19365_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18850_lanthipeptide

Lanthipeptides: U722_RS20005_lanthipeptide

1

VFHPCPNCKTGTDLTPVIKRLERMVQDAKVRLDARV

36

VFHPCPNCKTGTDLTPVIKRLERMVQDAK RLDARV

1

VFHPCPNCKTGTDLTPVIKRLERMVQDAKARLDARV

36

with 3 more sequence matches

87.2%

NZ_CP025341.1:

Lanthipeptides: CXR48_RS19565_lanthipeptide

1

VFHPCPNCKTGTDLTPVIKRLERMVQDAKVRLDARV

36

VFHPCPNCKTGTDLTPVIKRLERMVQDAK RLD RV

1

VFHPCPNCKTGTDLTPVIKRLERMVQDAKARLDLRV

36

20.5%

NC_015600.1and 17 others:

NZ_AP020310.1 Lanthipeptides: SAGCMC97051_RS07300_lanthipeptideNZ_ATVP01000001.1 Lanthipeptides: G574_RS11150_lanthipeptideNZ_BCFB01000042.1 Lanthipeptides: GOZ36_RS07980_lanthipeptideNZ_CP024974.1 Lanthipeptides: CVO91_RS06555_lanthipeptideNZ_CP068708.1 Lanthipeptides: JM964_RS04040_lanthipeptideNZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptideNZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptideNZ_FIKS01000005.1 Lanthipeptides: A0525_RS10015_lanthipeptideNZ_GL636070.1 Lanthipeptides: HMPREF9171_RS106200_lanthipeptideNZ_JADPLU010000018.1 Lanthipeptides: I4V82_RS09545_lanthipeptideNZ_JAIMDQ010000006.1 Lanthipeptides: K6V44_RS04045_lanthipeptideNZ_JAKVIE010000017.1 Lanthipeptides: MK857_RS08340_lanthipeptideNZ_JAMDIB010000004.1 Lanthipeptides: M5P35_RS04030_lanthipeptideNZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptideNZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptideNZ_LR594050.1 Lanthipeptides: FGL20_RS03485_lanthipeptideNZ_SSXN01000004.1 Lanthipeptides: FAJ36_RS04715_lanthipeptide

Lanthipeptides: SGPB_RS10680_lanthipeptide

6

PNCKTGTDLTPVIK

19

P CKTG +T IK

9

PGCKTGILMTCAIK

22

20.5%

NZ_CP059471.1and 3 others:

NZ_FNZW01000001.1 Lanthipeptides: BMZ61_RS02110_lanthipeptideNZ_FOYC01000001.1 Lanthipeptides: BMZ88_RS03370_lanthipeptideNZ_KE384124.1 Lanthipeptides: G597_RS0106700_lanthipeptide

Lanthipeptides: H1R75_RS06635_lanthipeptide

6

PNCKTGTDLTPVIK

19

P CKTG +T IK

9

PGCKTGALMTCPIK

22

MIBiG 4.0 matches for LQ568_RS00520

12.8%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

6

PNCKTG

11

P CKTG

9

PGCKTG

14

LQ568_RS00590

Leader:

MKKDFQALTPMTEEELKNLAGG

Core:

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

Core with dehydrations:

DhaDADhbPMDhbVDhbPDhbDhbIDhbIPIDhaLAGCysPDhbDhbKCysADhaIVDhaPCysND

antiSMASH-DB 4.0 matches for LQ568_RS00590

100.0%

NC_023073.1and 71 others:

NC_023073.1 Lanthipeptides: U722_RS19995_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide

Lanthipeptides: U722_RS19995_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

97.2%

NC_023073.1and 71 others:

NC_023073.1 Lanthipeptides: U722_RS19990_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide

Lanthipeptides: U722_RS19990_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

S+ATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

94.4%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10245_lanthipeptide

Lanthipeptides: J7E20_RS10245_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SDA PMT+TPTTITIPISLAGCPTTKCASIVSPCND

1

SDAAPMTITPTTITIPISLAGCPTTKCASIVSPCND

36

with 60 more sequence matches

Only the first 10 are displayed here.

66.7%

NZ_JAMDLZ010000027.1:

Lanthipeptides: M5W82_RS15520_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP T+TIPISLAGCPTTKCASIVSPC

8

TPLTVTIPISLAGCPTTKCASIVSPCKG

35

63.9%

NZ_WIXN01000006.1and 1 other:

NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide

Lanthipeptides: GHD25_RS06900_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPC

34

DATP T PTTI IP+SLA CPTT C S SPC

1

EDATPDT-HPTTI-IPVSLAVCPTTTCRSFSSPC

32

63.2%

NZ_AUCI01000015.1and 1 other:

NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide

Lanthipeptides: G475_RS0114655_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SD P + TT+TIPIS GCPTTKCAS+V PCND

3

SDQQPASHPTTTVTIPISAWGCPTTKCASVVEPCND

38

63.2%

NZ_FOXD01000022.1and 1 other:

NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide

Lanthipeptides: BM124_RS15255_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SD P + TT+TIPIS GCPTTKCAS+V PCND

3

SDQQPASHPTTTVTIPISAWGCPTTKCASVVKPCND

38

61.1%

NZ_CP063142.1and 5 others:

NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide

Lanthipeptides: HPB58_RS21455_lanthipeptide

12

TITIPISLAGCPTTKCASIVSPCND

36

T+TIPISLA CPTT+CASIVSPCND

8

TVTIPISLAACPTTQCASIVSPCND

32

61.1%

NZ_LT745762.1and 1 other:

NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide

Lanthipeptides: B2C77_RS21505_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP TI IP+SLA CPTTKCAS+V PCND

7

TPATI-IPVSLAICPTTKCASVVKPCND

33

58.3%

NZ_BOSN01000007.1and 3 others:

NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide

Lanthipeptides: KJS43_RS18000_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP TI IP+SLA CPTTKCAS+V PCN

7

TPATI-IPVSLAICPTTKCASVVKPCNG

33

58.3%

NZ_BQME02000001.1and 3 others:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide

Lanthipeptides: MFF31_RS04090_lanthipeptide

12

TITIPISLAGCPTTKCASIVSPCN

35

TI IPISLA CPTT+CASIVSPCN

6

TIIIPISLAACPTTRCASIVSPCN

29

55.6%

NZ_BQME02000001.1and 1 other:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04085_lanthipeptide

Lanthipeptides: MFF31_RS04085_lanthipeptide

12

TITIPISLAGCPTTKCASIVSPCN

35

TI IPISLA CPTT+CASIVS CN

6

TIIIPISLAACPTTRCASIVSSCN

29

55.6%

NZ_KQ040792.1and 1 other:

NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide

Lanthipeptides: WH45_RS23705_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP TI IP+SLA CPTT+CASIV CN

8

TPATI-IPVSLAICPTTRCASIVESCNG

34

MIBiG 4.0 matches for LQ568_RS00590

24.3%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

13

ITIPISLAGCPTTKCAS

29

+ + +S A CPTTKC S

19

VAVGVSAAFCPTTKCTS

35

19.4%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

22

CPTTKCAS

29

CPTTKC S

17

CPTTKCTS

24

LQ568_RS00595

Leader:

MKKEFLALELMTEEELKELAGG

Core:

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

Core with dehydrations:

DhaEADhbPMDhbVDhbPDhbDhbIDhbIPIDhaLAGCysPDhbDhbKCysADhaIVDhaPCysND

antiSMASH-DB 4.0 matches for LQ568_RS00595

100.0%

NC_023073.1and 71 others:

NC_023073.1 Lanthipeptides: U722_RS19990_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide

Lanthipeptides: U722_RS19990_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

97.2%

NC_023073.1and 71 others:

NC_023073.1 Lanthipeptides: U722_RS19995_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide

Lanthipeptides: U722_RS19995_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

S+ATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

97.2%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10240_lanthipeptide

Lanthipeptides: J7E20_RS10240_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SEATPMT+TPTTITIPISLAGCPTTKCASIVSPCND

1

SEATPMTITPTTITIPISLAGCPTTKCASIVSPCND

36

with 60 more sequence matches

Only the first 10 are displayed here.

91.7%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10245_lanthipeptide

Lanthipeptides: J7E20_RS10245_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

S+A PMT+TPTTITIPISLAGCPTTKCASIVSPCND

1

SDAAPMTITPTTITIPISLAGCPTTKCASIVSPCND

36

66.7%

NZ_JAMDLZ010000027.1:

Lanthipeptides: M5W82_RS15520_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP T+TIPISLAGCPTTKCASIVSPC

8

TPLTVTIPISLAGCPTTKCASIVSPCKG

35

63.9%

NZ_KQ040792.1and 1 other:

NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide

Lanthipeptides: WH45_RS23705_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCN

35

+E+TP TP TI IP+SLA CPTT+CASIV CN

1

AESTP-NGTPATI-IPVSLAICPTTRCASIVESCN

33

61.1%

NZ_CP063142.1and 5 others:

NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide

Lanthipeptides: HPB58_RS21455_lanthipeptide

12

TITIPISLAGCPTTKCASIVSPCND

36

T+TIPISLA CPTT+CASIVSPCND

8

TVTIPISLAACPTTQCASIVSPCND

32

61.1%

NZ_LT745762.1and 1 other:

NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide

Lanthipeptides: B2C77_RS21505_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP TI IP+SLA CPTTKCAS+V PCND

7

TPATI-IPVSLAICPTTKCASVVKPCND

33

61.1%

NZ_WIXN01000006.1and 1 other:

NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide

Lanthipeptides: GHD25_RS06900_lanthipeptide

2

EATPMTVTPTTITIPISLAGCPTTKCASIVSPC

34

+ATP T PTTI IP+SLA CPTT C S SPC

2

DATPDT-HPTTI-IPVSLAVCPTTTCRSFSSPC

32

60.5%

NZ_AUCI01000015.1and 1 other:

NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide

Lanthipeptides: G475_RS0114655_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

S+ P + TT+TIPIS GCPTTKCAS+V PCND

3

SDQQPASHPTTTVTIPISAWGCPTTKCASVVEPCND

38

60.5%

NZ_FOXD01000022.1and 1 other:

NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide

Lanthipeptides: BM124_RS15255_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

S+ P + TT+TIPIS GCPTTKCAS+V PCND

3

SDQQPASHPTTTVTIPISAWGCPTTKCASVVKPCND

38

58.3%

NZ_BOSN01000007.1and 3 others:

NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide

Lanthipeptides: KJS43_RS18000_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP TI IP+SLA CPTTKCAS+V PCN

7

TPATI-IPVSLAICPTTKCASVVKPCNG

33

58.3%

NZ_BQME02000001.1and 3 others:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide

Lanthipeptides: MFF31_RS04090_lanthipeptide

12

TITIPISLAGCPTTKCASIVSPCN

35

TI IPISLA CPTT+CASIVSPCN

6

TIIIPISLAACPTTRCASIVSPCN

29

MIBiG 4.0 matches for LQ568_RS00595

24.3%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

13

ITIPISLAGCPTTKCAS

29

+ + +S A CPTTKC S

19

VAVGVSAAFCPTTKCTS

35

19.4%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

22

CPTTKCAS

29

CPTTKC S

17

CPTTKCTS

24

LQ568_RS00610

Leader:

MNEKMYRFAGDLREELEEISLS

Core:

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

Core with dehydrations:

EFDhaGGGGAEQRGIDhaQGNDGKLCysDhbLDhbWECysGLCysPDhbHDhbCysWCys

antiSMASH-DB 4.0 matches for LQ568_RS00610

100.0%

NC_023073.1and 65 others:

NC_023073.1 Lanthipeptides: U722_RS06170_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptide

Lanthipeptides: U722_RS06170_lanthipeptide

1

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

1

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

97.4%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10220_lanthipeptide

Lanthipeptides: J7E20_RS10220_lanthipeptide

1

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTC+C

1

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCFC

38

86.8%

NZ_CP016371.1and 7 others:

NZ_CP016371.1 Lanthipeptides: A5891_RS06120_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptide

Lanthipeptides: A5891_RS06120_lanthipeptide

6

GGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

GGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

1

GGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

33

with 92 more sequence matches

Only the first 10 are displayed here.

71.1%

NZ_BQME02000001.1and 1 other:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04105_lanthipeptide

Lanthipeptides: MFF31_RS04105_lanthipeptide

8

AEQRGISQGNDGKLCTLTWECGLCPTHTC-WC

38

AEQRGISQGNDGK CTLTWEC +CPT TC WC

1

AEQRGISQGNDGKYCTLTWECSVCPTLTCFWC

32

68.4%

NZ_CP063142.1and 10 others:

NZ_CP063142.1 Lanthipeptides: HPB58_RS21475_lanthipeptideNZ_FOXX01000007.1 Lanthipeptides: BM012_RS26100_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptideNZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptideNZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptideNZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptideNZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptide

Lanthipeptides: HPB58_RS21475_lanthipeptide

8

AEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AEQRGISQGNDG CT+TWEC +CPTHTCWC

1

AEQRGISQGNDGHQCTITWECSICPTHTCWC

31

68.4%

NZ_FOXD01000022.1and 1 other:

NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15270_lanthipeptide

Lanthipeptides: BM124_RS15270_lanthipeptide

8

AEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AE RGISQGNDG CT+TWECG+CPTHTCWC

3

AEPRGISQGNDGDYCTITWECGMCPTHTCWC

33

68.4%

NZ_KQ040792.1and 1 other:

NZ_KQ040792.1 Lanthipeptides: WH45_RS23330_lanthipeptide

Lanthipeptides: WH45_RS23330_lanthipeptide

8

AEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AE +G+SQGNDGK+CTLTWECGLCPTHTC+C

1

AEVQGLSQGNDGKVCTLTWECGLCPTHTCFC

31

65.8%

NZ_BOSN01000007.1and 3 others:

NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18005_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptide

Lanthipeptides: KJS43_RS18005_lanthipeptide

7

GAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AE GISQGNDGK CT+TWEC +CPTHTCWC

1

AAEPMGISQGNDGKYCTITWECSICPTHTCWC

32

65.8%

NZ_LT745762.1and 1 other:

NZ_LT745762.1 Lanthipeptides: B2C77_RS00795_lanthipeptide

Lanthipeptides: B2C77_RS00795_lanthipeptide

7

GAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AE GISQGNDGK CT+TWEC +CPTHTCWC

1

AAEPMGISQGNDGKWCTVTWECSICPTHTCWC

32

63.2%

NZ_AUCI01000015.1and 1 other:

NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114640_lanthipeptide

Lanthipeptides: G475_RS0114640_lanthipeptide

6

GGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

E RG+SQGNDG CT+TWECG+CPTHTCWC

1

ADVETRGLSQGNDGDYCTITWECGMCPTHTCWC

33

63.2%

NZ_CP101913.1and 1 other:

NZ_CP101913.1 Lanthipeptides: NP440_RS09135_lanthipeptide

Lanthipeptides: NP440_RS09135_lanthipeptide

7

GAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AE GIS+ NDGK CTLTWEC +CPTHTCWC

1

AAEPMGISEDNDGKYCTLTWECSICPTHTCWC

32

63.2%

NZ_KV917378.1and 1 other:

NZ_KV917378.1 Lanthipeptides: BK581_RS07320_lanthipeptide

Lanthipeptides: BK581_RS07320_lanthipeptide

8

AEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

A+ +GISQGNDGK CT+TWEC +CPTHTCWC

1

ADVQGISQGNDGKYCTITWECSICPTHTCWC

31

55.3%

NZ_CP040417.1and 7 others:

NZ_CP040417.1 Lanthipeptides: FE328_RS09040_lanthipeptideNZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptideNZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptideNZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptideNZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide

Lanthipeptides: FE328_RS09040_lanthipeptide

5

GGGAEQRGISQGNDGKLCTLTWECGLCPTHTCW

37

G G R +S+GN GK+CTLTWECG+CP+HTC+

1

GVGKWIRKLSKGNTGKVCTLTWECGICPSHTCF

33

MIBiG 4.0 matches for LQ568_RS00610

23.7%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

16

GNDGKLCTLTWEC

28

GN G CTLT EC

11

GNKGAYCTLTVEC

23

23.7%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

16

GNDGKLCTLTWEC

28

GN+G CTLT EC

13

GNNGGWCTLTKEC

25

15.8%

BGC0000580.3 (EGD17355.1):

Lasso peptide: xanthomonin II or xanthomonin I

6

GGAEQRGISQ

15

GG GISQ

10

GGITTLGISQ

19

with 1 more sequence matches

12.8%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

22

CTLTWEC

28

CTL+ EC

28

CTLSKEC

34

allorf_101096_101173

Leader:

MRIHSIFIRMQGLYA

Core:

QVICPTNATY

Core with dehydrations:

QVICysPDhbNADhbY

antiSMASH-DB 4.0 matches for allorf_101096_101173

100.0%

NZ_CP016371.1and 22 others:

NZ_CP017775.1 Lanthipeptides: allorf_1370160_1370237_lanthipeptideNZ_CP018295.1 Lanthipeptides: allorf_1230930_1231007_lanthipeptideNZ_CP023075.1 Lanthipeptides: allorf_1287116_1287193_lanthipeptideNZ_CP027429.1 Lanthipeptides: allorf_2639262_2639339_lanthipeptideNZ_CP027429.1 Lanthipeptides: allorf_2639262_2639339_lanthipeptideNZ_CP033967.1 Lanthipeptides: allorf_3538116_3538193_lanthipeptideNZ_CP033967.1 Lanthipeptides: allorf_3538116_3538193_lanthipeptideNZ_CP044133.1 Lanthipeptides: allorf_1292127_1292204_lanthipeptideNZ_CP044444.1 Lanthipeptides: allorf_2627237_2627314_lanthipeptideNZ_CP048002.1 Lanthipeptides: allorf_3123788_3123865_lanthipeptideNZ_CP059405.1 Lanthipeptides: allorf_3176215_3176292_lanthipeptideNZ_CP059495.1 Lanthipeptides: allorf_1278377_1278454_lanthipeptideNZ_CP064091.1 Lanthipeptides: allorf_3836090_3836167_lanthipeptideNZ_CP083716.1 Lanthipeptides: allorf_110856_110933_lanthipeptideNZ_CP092110.1 Lanthipeptides: allorf_0704361_0704438_lanthipeptideNZ_CP092110.1 Lanthipeptides: allorf_0704361_0704438_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: allorf_101096_101173_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: allorf_101096_101173_lanthipeptideNZ_KB206086.1 Lanthipeptides: allorf_0474373_0474450_lanthipeptideNZ_KN050798.1 Lanthipeptides: allorf_0351480_0351557_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: allorf_337625_337702_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: allorf_337625_337702_lanthipeptide

Lanthipeptides: allorf_1210473_1210550_lanthipeptide

1

QVICPTNATY

10

QVICPTNATY

1

QVICPTNATY

10

allorf_107486_107668

Leader:

MKGGEIWNMKKNFSALYETSEQELKELVGG

Core:

QNSVSITTYPITNHICPTITVGCACPQRQV

Core with dehydrations:

QNDhaVDhaIDhbDhbYPIDhbNHICysPDhbIDhbVGCysACysPQRQV

antiSMASH-DB 4.0 matches for allorf_107486_107668

100.0%

NZ_CP016371.1and 25 others:

NZ_CP017775.1 Lanthipeptides: allorf_1362373_1362555_lanthipeptideNZ_CP018295.1 Lanthipeptides: allorf_1224462_1224620_lanthipeptideNZ_CP023075.1 Lanthipeptides: allorf_1280618_1280800_lanthipeptideNZ_CP027429.1 Lanthipeptides: allorf_2645650_2645832_lanthipeptideNZ_CP027429.1 Lanthipeptides: allorf_2645650_2645832_lanthipeptideNZ_CP033967.1 Lanthipeptides: allorf_3544503_3544661_lanthipeptideNZ_CP033967.1 Lanthipeptides: allorf_3544503_3544661_lanthipeptideNZ_CP035393.1 Lanthipeptides: allorf_1361512_1361694_lanthipeptideNZ_CP044133.1 Lanthipeptides: allorf_1285659_1285817_lanthipeptideNZ_CP044444.1 Lanthipeptides: allorf_2620740_2620922_lanthipeptideNZ_CP048002.1 Lanthipeptides: allorf_3117293_3117475_lanthipeptideNZ_CP059405.1 Lanthipeptides: allorf_3169717_3169899_lanthipeptideNZ_CP059495.1 Lanthipeptides: allorf_1271882_1272064_lanthipeptideNZ_CP064091.1 Lanthipeptides: allorf_3829595_3829777_lanthipeptideNZ_CP083716.1 Lanthipeptides: allorf_104358_104540_lanthipeptideNZ_CP092110.1 Lanthipeptides: allorf_0710754_0710936_lanthipeptideNZ_CP092110.1 Lanthipeptides: allorf_0710754_0710936_lanthipeptideNZ_CP116013.1 Lanthipeptides: allorf_0410910_0411092_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: allorf_107486_107668_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: allorf_107486_107668_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: allorf_050414_050596_lanthipeptideNZ_KB206086.1 Lanthipeptides: allorf_0467875_0468057_lanthipeptideNZ_KN050798.1 Lanthipeptides: allorf_0345012_0345170_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: allorf_344018_344200_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: allorf_344018_344200_lanthipeptide

Lanthipeptides: allorf_1203980_1204162_lanthipeptide

1

QNSVSITTYPITNHICPTITVGCACPQRQV

30

QNSVSITTYPITNHICPTITVGCACPQRQV

1

QNSVSITTYPITNHICPTITVGCACPQRQV

30

93.3%

NC_023073.1and 18 others:

NZ_CP010556.1 Lanthipeptides: allorf_1170865_1171047_lanthipeptideNZ_CP016395.1 Lanthipeptides: allorf_1266893_1267075_lanthipeptideNZ_CP023133.1 Lanthipeptides: allorf_0800979_0801161_lanthipeptideNZ_CP025341.1 Lanthipeptides: allorf_1207246_1207428_lanthipeptideNZ_CP028440.1 Lanthipeptides: allorf_1169247_1169429_lanthipeptideNZ_CP028440.1 Lanthipeptides: allorf_1169247_1169429_lanthipeptideNZ_CP031694.1 Lanthipeptides: allorf_3757607_3757789_lanthipeptideNZ_CP031694.1 Lanthipeptides: allorf_3757607_3757789_lanthipeptideNZ_CP065790.1 Lanthipeptides: allorf_1228836_1229018_lanthipeptideNZ_CP072310.1 Lanthipeptides: allorf_3340146_3340328_lanthipeptideNZ_CP074685.1 Lanthipeptides: allorf_1220760_1220942_lanthipeptideNZ_CP075054.1 Lanthipeptides: allorf_2702843_2703025_lanthipeptideNZ_CP075054.1 Lanthipeptides: allorf_2702843_2703025_lanthipeptideNZ_CP088300.1 Lanthipeptides: allorf_1174611_1174793_lanthipeptideNZ_CP090905.1 Lanthipeptides: allorf_1201177_1201359_lanthipeptideNZ_CP094618.1 Lanthipeptides: allorf_1135121_1135303_lanthipeptideNZ_CP119675.1 Lanthipeptides: allorf_2182837_2183019_lanthipeptideNZ_LN999829.1 Lanthipeptides: allorf_1186077_1186259_lanthipeptide

Lanthipeptides: allorf_1238739_1238921_lanthipeptide

1

QNSVSITTYPITNHICPTITVGCACPQRQV

30

QNSVSITT PITNH+CPTITVGCACPQRQV

1

QNSVSITTIPITNHVCPTITVGCACPQRQV

30

66.7%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10235_lanthipeptide

Lanthipeptides: J7E20_RS10235_lanthipeptide

1

QNSVSITTYPITNHICPTITVGCACPQRQV

30

QN +SITT P T H+C T+TVGCACPQ+Q+

1

QNLISITTIPFT-HLCATVTVGCACPQKQI

29

with 3 more sequence matches

23.5%

NZ_CP048048.1and 2 others:

NZ_CP048050.1 Lanthipeptides: GW570_RS15170_lanthipeptideNZ_CP088267.1 Lanthipeptides: LRE50_RS16510_lanthipeptide

Lanthipeptides: GW571_RS15175_lanthipeptide

8

TYPITNHICPTITVGCACPQRQ

29

T+ +T +C TI AC Q

8

TFKLTVKVCRTIITTTACGSTQ

29

20.0%

NZ_JANIOB010000033.1:

Lanthipeptides: NQ113_RS28010_lanthipeptide

11

ITNHICPTI

19

TN +CPTI

15

FTNRLCPTI

23

15.8%

NZ_KB907258.1:

Lanthipeptides: G358_RS0114910_lanthipeptide

2

NSVSITTYPITNHICPTIT

20

NS+ I+ Y + CP++

6

NSIRISIYKCLSLFCPSVA

24

MIBiG 4.0 matches for allorf_107486_107668

13.3%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

18

TITVGC

23

T+TV C

18

TLTVEC

23

Lanthipeptide(s) for LQ568_RS00605

LQ568_RS00590

Leader:

MKKDFQALTPMTEEELKNLAGG

Core:

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

Core with dehydrations:

DhaDADhbPMDhbVDhbPDhbDhbIDhbIPIDhaLAGCysPDhbDhbKCysADhaIVDhaPCysND

antiSMASH-DB 4.0 matches for LQ568_RS00590

100.0%

NC_023073.1and 71 others:

NC_023073.1 Lanthipeptides: U722_RS19995_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide

Lanthipeptides: U722_RS19995_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

97.2%

NC_023073.1and 71 others:

NC_023073.1 Lanthipeptides: U722_RS19990_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide

Lanthipeptides: U722_RS19990_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

S+ATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

94.4%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10245_lanthipeptide

Lanthipeptides: J7E20_RS10245_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SDA PMT+TPTTITIPISLAGCPTTKCASIVSPCND

1

SDAAPMTITPTTITIPISLAGCPTTKCASIVSPCND

36

with 60 more sequence matches

Only the first 10 are displayed here.

66.7%

NZ_JAMDLZ010000027.1:

Lanthipeptides: M5W82_RS15520_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP T+TIPISLAGCPTTKCASIVSPC

8

TPLTVTIPISLAGCPTTKCASIVSPCKG

35

63.9%

NZ_WIXN01000006.1and 1 other:

NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide

Lanthipeptides: GHD25_RS06900_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPC

34

DATP T PTTI IP+SLA CPTT C S SPC

1

EDATPDT-HPTTI-IPVSLAVCPTTTCRSFSSPC

32

63.2%

NZ_AUCI01000015.1and 1 other:

NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide

Lanthipeptides: G475_RS0114655_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SD P + TT+TIPIS GCPTTKCAS+V PCND

3

SDQQPASHPTTTVTIPISAWGCPTTKCASVVEPCND

38

63.2%

NZ_FOXD01000022.1and 1 other:

NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide

Lanthipeptides: BM124_RS15255_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SD P + TT+TIPIS GCPTTKCAS+V PCND

3

SDQQPASHPTTTVTIPISAWGCPTTKCASVVKPCND

38

61.1%

NZ_CP063142.1and 5 others:

NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide

Lanthipeptides: HPB58_RS21455_lanthipeptide

12

TITIPISLAGCPTTKCASIVSPCND

36

T+TIPISLA CPTT+CASIVSPCND

8

TVTIPISLAACPTTQCASIVSPCND

32

61.1%

NZ_LT745762.1and 1 other:

NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide

Lanthipeptides: B2C77_RS21505_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP TI IP+SLA CPTTKCAS+V PCND

7

TPATI-IPVSLAICPTTKCASVVKPCND

33

58.3%

NZ_BOSN01000007.1and 3 others:

NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide

Lanthipeptides: KJS43_RS18000_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP TI IP+SLA CPTTKCAS+V PCN

7

TPATI-IPVSLAICPTTKCASVVKPCNG

33

58.3%

NZ_BQME02000001.1and 3 others:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide

Lanthipeptides: MFF31_RS04090_lanthipeptide

12

TITIPISLAGCPTTKCASIVSPCN

35

TI IPISLA CPTT+CASIVSPCN

6

TIIIPISLAACPTTRCASIVSPCN

29

55.6%

NZ_BQME02000001.1and 1 other:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04085_lanthipeptide

Lanthipeptides: MFF31_RS04085_lanthipeptide

12

TITIPISLAGCPTTKCASIVSPCN

35

TI IPISLA CPTT+CASIVS CN

6

TIIIPISLAACPTTRCASIVSSCN

29

55.6%

NZ_KQ040792.1and 1 other:

NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide

Lanthipeptides: WH45_RS23705_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP TI IP+SLA CPTT+CASIV CN

8

TPATI-IPVSLAICPTTRCASIVESCNG

34

MIBiG 4.0 matches for LQ568_RS00590

24.3%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

13

ITIPISLAGCPTTKCAS

29

+ + +S A CPTTKC S

19

VAVGVSAAFCPTTKCTS

35

19.4%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

22

CPTTKCAS

29

CPTTKC S

17

CPTTKCTS

24

LQ568_RS00595

Leader:

MKKEFLALELMTEEELKELAGG

Core:

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

Core with dehydrations:

DhaEADhbPMDhbVDhbPDhbDhbIDhbIPIDhaLAGCysPDhbDhbKCysADhaIVDhaPCysND

antiSMASH-DB 4.0 matches for LQ568_RS00595

100.0%

NC_023073.1and 71 others:

NC_023073.1 Lanthipeptides: U722_RS19990_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide

Lanthipeptides: U722_RS19990_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

97.2%

NC_023073.1and 71 others:

NC_023073.1 Lanthipeptides: U722_RS19995_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide

Lanthipeptides: U722_RS19995_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

S+ATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

97.2%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10240_lanthipeptide

Lanthipeptides: J7E20_RS10240_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SEATPMT+TPTTITIPISLAGCPTTKCASIVSPCND

1

SEATPMTITPTTITIPISLAGCPTTKCASIVSPCND

36

with 60 more sequence matches

Only the first 10 are displayed here.

91.7%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10245_lanthipeptide

Lanthipeptides: J7E20_RS10245_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

S+A PMT+TPTTITIPISLAGCPTTKCASIVSPCND

1

SDAAPMTITPTTITIPISLAGCPTTKCASIVSPCND

36

66.7%

NZ_JAMDLZ010000027.1:

Lanthipeptides: M5W82_RS15520_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP T+TIPISLAGCPTTKCASIVSPC

8

TPLTVTIPISLAGCPTTKCASIVSPCKG

35

63.9%

NZ_KQ040792.1and 1 other:

NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide

Lanthipeptides: WH45_RS23705_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCN

35

+E+TP TP TI IP+SLA CPTT+CASIV CN

1

AESTP-NGTPATI-IPVSLAICPTTRCASIVESCN

33

61.1%

NZ_CP063142.1and 5 others:

NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide

Lanthipeptides: HPB58_RS21455_lanthipeptide

12

TITIPISLAGCPTTKCASIVSPCND

36

T+TIPISLA CPTT+CASIVSPCND

8

TVTIPISLAACPTTQCASIVSPCND

32

61.1%

NZ_LT745762.1and 1 other:

NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide

Lanthipeptides: B2C77_RS21505_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP TI IP+SLA CPTTKCAS+V PCND

7

TPATI-IPVSLAICPTTKCASVVKPCND

33

61.1%

NZ_WIXN01000006.1and 1 other:

NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide

Lanthipeptides: GHD25_RS06900_lanthipeptide

2

EATPMTVTPTTITIPISLAGCPTTKCASIVSPC

34

+ATP T PTTI IP+SLA CPTT C S SPC

2

DATPDT-HPTTI-IPVSLAVCPTTTCRSFSSPC

32

60.5%

NZ_AUCI01000015.1and 1 other:

NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide

Lanthipeptides: G475_RS0114655_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

S+ P + TT+TIPIS GCPTTKCAS+V PCND

3

SDQQPASHPTTTVTIPISAWGCPTTKCASVVEPCND

38

60.5%

NZ_FOXD01000022.1and 1 other:

NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide

Lanthipeptides: BM124_RS15255_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

S+ P + TT+TIPIS GCPTTKCAS+V PCND

3

SDQQPASHPTTTVTIPISAWGCPTTKCASVVKPCND

38

58.3%

NZ_BOSN01000007.1and 3 others:

NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide

Lanthipeptides: KJS43_RS18000_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP TI IP+SLA CPTTKCAS+V PCN

7

TPATI-IPVSLAICPTTKCASVVKPCNG

33

58.3%

NZ_BQME02000001.1and 3 others:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide

Lanthipeptides: MFF31_RS04090_lanthipeptide

12

TITIPISLAGCPTTKCASIVSPCN

35

TI IPISLA CPTT+CASIVSPCN

6

TIIIPISLAACPTTRCASIVSPCN

29

MIBiG 4.0 matches for LQ568_RS00595

24.3%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

13

ITIPISLAGCPTTKCAS

29

+ + +S A CPTTKC S

19

VAVGVSAAFCPTTKCTS

35

19.4%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

22

CPTTKCAS

29

CPTTKC S

17

CPTTKCTS

24

LQ568_RS00610

Leader:

MNEKMYRFAGDLREELEEISLS

Core:

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

Core with dehydrations:

EFDhaGGGGAEQRGIDhaQGNDGKLCysDhbLDhbWECysGLCysPDhbHDhbCysWCys

antiSMASH-DB 4.0 matches for LQ568_RS00610

100.0%

NC_023073.1and 65 others:

NC_023073.1 Lanthipeptides: U722_RS06170_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptide

Lanthipeptides: U722_RS06170_lanthipeptide

1

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

1

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

97.4%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10220_lanthipeptide

Lanthipeptides: J7E20_RS10220_lanthipeptide

1

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTC+C

1

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCFC

38

86.8%

NZ_CP016371.1and 7 others:

NZ_CP016371.1 Lanthipeptides: A5891_RS06120_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptide

Lanthipeptides: A5891_RS06120_lanthipeptide

6

GGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

GGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

1

GGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

33

with 92 more sequence matches

Only the first 10 are displayed here.

71.1%

NZ_BQME02000001.1and 1 other:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04105_lanthipeptide

Lanthipeptides: MFF31_RS04105_lanthipeptide

8

AEQRGISQGNDGKLCTLTWECGLCPTHTC-WC

38

AEQRGISQGNDGK CTLTWEC +CPT TC WC

1

AEQRGISQGNDGKYCTLTWECSVCPTLTCFWC

32

68.4%

NZ_CP063142.1and 10 others:

NZ_CP063142.1 Lanthipeptides: HPB58_RS21475_lanthipeptideNZ_FOXX01000007.1 Lanthipeptides: BM012_RS26100_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptideNZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptideNZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptideNZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptideNZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptide

Lanthipeptides: HPB58_RS21475_lanthipeptide

8

AEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AEQRGISQGNDG CT+TWEC +CPTHTCWC

1

AEQRGISQGNDGHQCTITWECSICPTHTCWC

31

68.4%

NZ_FOXD01000022.1and 1 other:

NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15270_lanthipeptide

Lanthipeptides: BM124_RS15270_lanthipeptide

8

AEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AE RGISQGNDG CT+TWECG+CPTHTCWC

3

AEPRGISQGNDGDYCTITWECGMCPTHTCWC

33

68.4%

NZ_KQ040792.1and 1 other:

NZ_KQ040792.1 Lanthipeptides: WH45_RS23330_lanthipeptide

Lanthipeptides: WH45_RS23330_lanthipeptide

8

AEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AE +G+SQGNDGK+CTLTWECGLCPTHTC+C

1

AEVQGLSQGNDGKVCTLTWECGLCPTHTCFC

31

65.8%

NZ_BOSN01000007.1and 3 others:

NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18005_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptide

Lanthipeptides: KJS43_RS18005_lanthipeptide

7

GAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AE GISQGNDGK CT+TWEC +CPTHTCWC

1

AAEPMGISQGNDGKYCTITWECSICPTHTCWC

32

65.8%

NZ_LT745762.1and 1 other:

NZ_LT745762.1 Lanthipeptides: B2C77_RS00795_lanthipeptide

Lanthipeptides: B2C77_RS00795_lanthipeptide

7

GAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AE GISQGNDGK CT+TWEC +CPTHTCWC

1

AAEPMGISQGNDGKWCTVTWECSICPTHTCWC

32

63.2%

NZ_AUCI01000015.1and 1 other:

NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114640_lanthipeptide

Lanthipeptides: G475_RS0114640_lanthipeptide

6

GGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

E RG+SQGNDG CT+TWECG+CPTHTCWC

1

ADVETRGLSQGNDGDYCTITWECGMCPTHTCWC

33

63.2%

NZ_CP101913.1and 1 other:

NZ_CP101913.1 Lanthipeptides: NP440_RS09135_lanthipeptide

Lanthipeptides: NP440_RS09135_lanthipeptide

7

GAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AE GIS+ NDGK CTLTWEC +CPTHTCWC

1

AAEPMGISEDNDGKYCTLTWECSICPTHTCWC

32

63.2%

NZ_KV917378.1and 1 other:

NZ_KV917378.1 Lanthipeptides: BK581_RS07320_lanthipeptide

Lanthipeptides: BK581_RS07320_lanthipeptide

8

AEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

A+ +GISQGNDGK CT+TWEC +CPTHTCWC

1

ADVQGISQGNDGKYCTITWECSICPTHTCWC

31

55.3%

NZ_CP040417.1and 7 others:

NZ_CP040417.1 Lanthipeptides: FE328_RS09040_lanthipeptideNZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptideNZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptideNZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptideNZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide

Lanthipeptides: FE328_RS09040_lanthipeptide

5

GGGAEQRGISQGNDGKLCTLTWECGLCPTHTCW

37

G G R +S+GN GK+CTLTWECG+CP+HTC+

1

GVGKWIRKLSKGNTGKVCTLTWECGICPSHTCF

33

MIBiG 4.0 matches for LQ568_RS00610

23.7%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

16

GNDGKLCTLTWEC

28

GN G CTLT EC

11

GNKGAYCTLTVEC

23

23.7%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

16

GNDGKLCTLTWEC

28

GN+G CTLT EC

13

GNNGGWCTLTKEC

25

15.8%

BGC0000580.3 (EGD17355.1):

Lasso peptide: xanthomonin II or xanthomonin I

6

GGAEQRGISQ

15

GG GISQ

10

GGITTLGISQ

19

with 1 more sequence matches

12.8%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

22

CTLTWEC

28

CTL+ EC

28

CTLSKEC

34

allorf_101096_101173

Leader:

MRIHSIFIRMQGLYA

Core:

QVICPTNATY

Core with dehydrations:

QVICysPDhbNADhbY

antiSMASH-DB 4.0 matches for allorf_101096_101173

100.0%

NZ_CP016371.1and 22 others:

NZ_CP017775.1 Lanthipeptides: allorf_1370160_1370237_lanthipeptideNZ_CP018295.1 Lanthipeptides: allorf_1230930_1231007_lanthipeptideNZ_CP023075.1 Lanthipeptides: allorf_1287116_1287193_lanthipeptideNZ_CP027429.1 Lanthipeptides: allorf_2639262_2639339_lanthipeptideNZ_CP027429.1 Lanthipeptides: allorf_2639262_2639339_lanthipeptideNZ_CP033967.1 Lanthipeptides: allorf_3538116_3538193_lanthipeptideNZ_CP033967.1 Lanthipeptides: allorf_3538116_3538193_lanthipeptideNZ_CP044133.1 Lanthipeptides: allorf_1292127_1292204_lanthipeptideNZ_CP044444.1 Lanthipeptides: allorf_2627237_2627314_lanthipeptideNZ_CP048002.1 Lanthipeptides: allorf_3123788_3123865_lanthipeptideNZ_CP059405.1 Lanthipeptides: allorf_3176215_3176292_lanthipeptideNZ_CP059495.1 Lanthipeptides: allorf_1278377_1278454_lanthipeptideNZ_CP064091.1 Lanthipeptides: allorf_3836090_3836167_lanthipeptideNZ_CP083716.1 Lanthipeptides: allorf_110856_110933_lanthipeptideNZ_CP092110.1 Lanthipeptides: allorf_0704361_0704438_lanthipeptideNZ_CP092110.1 Lanthipeptides: allorf_0704361_0704438_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: allorf_101096_101173_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: allorf_101096_101173_lanthipeptideNZ_KB206086.1 Lanthipeptides: allorf_0474373_0474450_lanthipeptideNZ_KN050798.1 Lanthipeptides: allorf_0351480_0351557_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: allorf_337625_337702_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: allorf_337625_337702_lanthipeptide

Lanthipeptides: allorf_1210473_1210550_lanthipeptide

1

QVICPTNATY

10

QVICPTNATY

1

QVICPTNATY

10

allorf_107486_107668

Leader:

MKGGEIWNMKKNFSALYETSEQELKELVGG

Core:

QNSVSITTYPITNHICPTITVGCACPQRQV

Core with dehydrations:

QNDhaVDhaIDhbDhbYPIDhbNHICysPDhbIDhbVGCysACysPQRQV

antiSMASH-DB 4.0 matches for allorf_107486_107668

100.0%

NZ_CP016371.1and 25 others:

NZ_CP017775.1 Lanthipeptides: allorf_1362373_1362555_lanthipeptideNZ_CP018295.1 Lanthipeptides: allorf_1224462_1224620_lanthipeptideNZ_CP023075.1 Lanthipeptides: allorf_1280618_1280800_lanthipeptideNZ_CP027429.1 Lanthipeptides: allorf_2645650_2645832_lanthipeptideNZ_CP027429.1 Lanthipeptides: allorf_2645650_2645832_lanthipeptideNZ_CP033967.1 Lanthipeptides: allorf_3544503_3544661_lanthipeptideNZ_CP033967.1 Lanthipeptides: allorf_3544503_3544661_lanthipeptideNZ_CP035393.1 Lanthipeptides: allorf_1361512_1361694_lanthipeptideNZ_CP044133.1 Lanthipeptides: allorf_1285659_1285817_lanthipeptideNZ_CP044444.1 Lanthipeptides: allorf_2620740_2620922_lanthipeptideNZ_CP048002.1 Lanthipeptides: allorf_3117293_3117475_lanthipeptideNZ_CP059405.1 Lanthipeptides: allorf_3169717_3169899_lanthipeptideNZ_CP059495.1 Lanthipeptides: allorf_1271882_1272064_lanthipeptideNZ_CP064091.1 Lanthipeptides: allorf_3829595_3829777_lanthipeptideNZ_CP083716.1 Lanthipeptides: allorf_104358_104540_lanthipeptideNZ_CP092110.1 Lanthipeptides: allorf_0710754_0710936_lanthipeptideNZ_CP092110.1 Lanthipeptides: allorf_0710754_0710936_lanthipeptideNZ_CP116013.1 Lanthipeptides: allorf_0410910_0411092_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: allorf_107486_107668_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: allorf_107486_107668_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: allorf_050414_050596_lanthipeptideNZ_KB206086.1 Lanthipeptides: allorf_0467875_0468057_lanthipeptideNZ_KN050798.1 Lanthipeptides: allorf_0345012_0345170_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: allorf_344018_344200_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: allorf_344018_344200_lanthipeptide

Lanthipeptides: allorf_1203980_1204162_lanthipeptide

1

QNSVSITTYPITNHICPTITVGCACPQRQV

30

QNSVSITTYPITNHICPTITVGCACPQRQV

1

QNSVSITTYPITNHICPTITVGCACPQRQV

30

93.3%

NC_023073.1and 18 others:

NZ_CP010556.1 Lanthipeptides: allorf_1170865_1171047_lanthipeptideNZ_CP016395.1 Lanthipeptides: allorf_1266893_1267075_lanthipeptideNZ_CP023133.1 Lanthipeptides: allorf_0800979_0801161_lanthipeptideNZ_CP025341.1 Lanthipeptides: allorf_1207246_1207428_lanthipeptideNZ_CP028440.1 Lanthipeptides: allorf_1169247_1169429_lanthipeptideNZ_CP028440.1 Lanthipeptides: allorf_1169247_1169429_lanthipeptideNZ_CP031694.1 Lanthipeptides: allorf_3757607_3757789_lanthipeptideNZ_CP031694.1 Lanthipeptides: allorf_3757607_3757789_lanthipeptideNZ_CP065790.1 Lanthipeptides: allorf_1228836_1229018_lanthipeptideNZ_CP072310.1 Lanthipeptides: allorf_3340146_3340328_lanthipeptideNZ_CP074685.1 Lanthipeptides: allorf_1220760_1220942_lanthipeptideNZ_CP075054.1 Lanthipeptides: allorf_2702843_2703025_lanthipeptideNZ_CP075054.1 Lanthipeptides: allorf_2702843_2703025_lanthipeptideNZ_CP088300.1 Lanthipeptides: allorf_1174611_1174793_lanthipeptideNZ_CP090905.1 Lanthipeptides: allorf_1201177_1201359_lanthipeptideNZ_CP094618.1 Lanthipeptides: allorf_1135121_1135303_lanthipeptideNZ_CP119675.1 Lanthipeptides: allorf_2182837_2183019_lanthipeptideNZ_LN999829.1 Lanthipeptides: allorf_1186077_1186259_lanthipeptide

Lanthipeptides: allorf_1238739_1238921_lanthipeptide

1

QNSVSITTYPITNHICPTITVGCACPQRQV

30

QNSVSITT PITNH+CPTITVGCACPQRQV

1

QNSVSITTIPITNHVCPTITVGCACPQRQV

30

66.7%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10235_lanthipeptide

Lanthipeptides: J7E20_RS10235_lanthipeptide

1

QNSVSITTYPITNHICPTITVGCACPQRQV

30

QN +SITT P T H+C T+TVGCACPQ+Q+

1

QNLISITTIPFT-HLCATVTVGCACPQKQI

29

with 3 more sequence matches

23.5%

NZ_CP048048.1and 2 others:

NZ_CP048050.1 Lanthipeptides: GW570_RS15170_lanthipeptideNZ_CP088267.1 Lanthipeptides: LRE50_RS16510_lanthipeptide

Lanthipeptides: GW571_RS15175_lanthipeptide

8

TYPITNHICPTITVGCACPQRQ

29

T+ +T +C TI AC Q

8

TFKLTVKVCRTIITTTACGSTQ

29

20.0%

NZ_JANIOB010000033.1:

Lanthipeptides: NQ113_RS28010_lanthipeptide

11

ITNHICPTI

19

TN +CPTI

15

FTNRLCPTI

23

15.8%

NZ_KB907258.1:

Lanthipeptides: G358_RS0114910_lanthipeptide

2

NSVSITTYPITNHICPTIT

20

NS+ I+ Y + CP++

6

NSIRISIYKCLSLFCPSVA

24

MIBiG 4.0 matches for allorf_107486_107668

13.3%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

18

TITVGC

23

T+TV C

18

TLTVEC

23

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 23.52 out of 24.78

Confidence: strong

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.38 out of 26.06

Confidence: medium

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.57 out of 20.01

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.90 out of 27.78

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.27 out of 23.79

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.96 out of 28.19

Confidence: medium

Additional weak hits (4):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.13 out of 30.22

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 26.26 out of 36.54

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.46 out of 30.11

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 20.85 out of 30.22

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

LQ568_RS00590 - Class II

Cleavage pHMM score: 3.30

RODEO score: 0

Monoisotopic mass: 3389.7 Da

Molecular weight: 3391.9 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3409.9 Da N = 1; 3427.9 Da N = 2; 3446.0 Da N = 3; 3464.0 Da N = 4; 3482.0 Da N = 5; 3500.0 Da N = 6; 3518.0 Da N = 7; 3536.1 Da N = 8; 3554.1 Da N = 9

LQ568_RS00595 - Class II

Cleavage pHMM score: 3.30

RODEO score: 0

Monoisotopic mass: 3403.7 Da

Molecular weight: 3405.9 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3423.9 Da N = 1; 3442.0 Da N = 2; 3460.0 Da N = 3; 3478.0 Da N = 4; 3496.0 Da N = 5; 3514.0 Da N = 6; 3532.1 Da N = 7; 3550.1 Da N = 8; 3568.1 Da N = 9

LQ568_RS00610 - Class II

Cleavage pHMM score: -4.60

RODEO score: 0

Monoisotopic mass: 3892.7 Da

Molecular weight: 3895.3 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 3913.3 Da N = 1

allorf_101096_101173 - Class II

Cleavage pHMM score: -5.60

RODEO score: 0

Monoisotopic mass: 1072.5 Da

Molecular weight: 1073.2 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1091.2 Da N = 1

allorf_107486_107668 - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 3117.6 Da

Molecular weight: 3119.6 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3137.6 Da N = 1; 3155.6 Da N = 2; 3173.6 Da N = 3; 3191.6 Da N = 4

LQ568_RS00520 - Class II

Cleavage pHMM score: -7.30

RODEO score: 0

Monoisotopic mass: 4455.4 Da

Molecular weight: 4458.2 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 4476.2 Da N = 1

LQ568_RS00590 - Class II

Cleavage pHMM score: 3.30

RODEO score: 0

Monoisotopic mass: 3389.7 Da

Molecular weight: 3391.9 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3409.9 Da N = 1; 3427.9 Da N = 2; 3446.0 Da N = 3; 3464.0 Da N = 4; 3482.0 Da N = 5; 3500.0 Da N = 6; 3518.0 Da N = 7; 3536.1 Da N = 8; 3554.1 Da N = 9

LQ568_RS00595 - Class II

Cleavage pHMM score: 3.30

RODEO score: 0

Monoisotopic mass: 3403.7 Da

Molecular weight: 3405.9 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3423.9 Da N = 1; 3442.0 Da N = 2; 3460.0 Da N = 3; 3478.0 Da N = 4; 3496.0 Da N = 5; 3514.0 Da N = 6; 3532.1 Da N = 7; 3550.1 Da N = 8; 3568.1 Da N = 9

LQ568_RS00610 - Class II

Cleavage pHMM score: -4.60

RODEO score: 0

Monoisotopic mass: 3892.7 Da

Molecular weight: 3895.3 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 3913.3 Da N = 1

allorf_101096_101173 - Class II

Cleavage pHMM score: -5.60

RODEO score: 0

Monoisotopic mass: 1072.5 Da

Molecular weight: 1073.2 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1091.2 Da N = 1

allorf_107486_107668 - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 3117.6 Da

Molecular weight: 3119.6 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3137.6 Da N = 1; 3155.6 Da N = 2; 3173.6 Da N = 3; 3191.6 Da N = 4

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
ArgR	Regulator of arginine biosynthesis genes
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
IolR	Regulator of the inositol catabolism
LexA variant 2	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
ZuR variant 1	Zinc-responsive repressor

NZ_JAJNPN010000001.1 - Region 2 - NRPS,T3PKS,transAT-PKS

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Location: 145,967 - 263,908 nt. (total: 117,942 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

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NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

LQ568_RS00910: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

LQ568_RS19760: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acylase sulfhydrylase

LQ568_RS00955: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

LQ568_RS01000: O-succinylhomoserine sulfhydrylase

smcogs: SMCOG1168: O-succinylhomoserine sulfhydrylase

LQ568_RS01005: O-succinylhomoserine sulfhydrylase

smcogs: SMCOG1168: O-succinylhomoserine sulfhydrylase

Hydrolases: deacetylase esterase

LQ568_RS00865: polysaccharide deacetylase

smcogs: SMCOG1235: polysaccharide deacetylase

LQ568_RS01010: enterobactin/ferric enterobactin esterase

smcogs: SMCOG1098: enterobactin/ferric enterobactin esterase

Lyases: dehydratase

LQ568_RS00800: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: ligase synthase

LQ568_RS00905: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

LQ568_RS00915: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

LQ568_RS00940: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

LQ568_RS00950: hydroxymethylglutaryl-CoA synthase

smcogs: SMCOG1043: hydroxymethylglutaryl-CoA synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	1.22	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	1.19	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001758.4	1.10	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001833.4	1.08	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	1.08	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	1.06	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001166.5	1.06	NRPS	HC-toxin	Alternaria jesenskae
BGC0001132.4	1.05	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000307.4	1.04	NRPS	AbT1	Aureobasidium pullulans
BGC0001825.4	1.03	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.75	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.74	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0000342.4	0.72	NRPS	enniatin	Fusarium equiseti
BGC0001758.4	0.71	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001833.4	0.71	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.70	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001166.5	0.70	NRPS	HC-toxin	Alternaria jesenskae
BGC0002286.3	0.70	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001261.3	0.69	NRPS	AM-toxin	Alternaria alternata
BGC0000307.4	0.69	NRPS	AbT1	Aureobasidium pullulans

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.55 out of 18.46

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.52 out of 26.06

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.85 out of 20.97

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.11 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.67 out of 26.06

Confidence: medium

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 23.52 out of 26.33

Confidence: strong

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.69 out of 32.93

Confidence: medium

Additional weak hits (10):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.89 out of 26.06

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.61 out of 23.43

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.00 out of 30.25

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.49 out of 36.54

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.01 out of 36.54

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.36 out of 30.11

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.05 out of 30.11

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.03 out of 29.25

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.62 out of 29.25

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.49 out of 32.93

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 2, location 145966 - 263908:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Thr - NMe-X) + (ohmal - mal - ohmal - mal - mal) + (Ala - Me-ccmal - mal - Gly - ohmal - mal) + (ccmal - mal - ccmal - mal) + (Ser - Ala)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

LQ568_RS00905: Ser - Ala

Search NORINE for peptide: strict or relaxed

AMP-binding (497..906): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWMTFDVSVWELHFFCSGEFNLYGPTEAAIDVSH
Nearest Stachelhaus code(s):: Ser DVWHFSLIDK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1596..2014): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: TFLTFDVSVSEGNFMVAGEENIYGPTEASIYTTY
Nearest Stachelhaus code(s):: Ala DVSNMAIIYK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

LQ568_RS00915: Ala - Gly

Search NORINE for peptide: strict or relaxed

AMP-binding (489..905): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: TFLTFDVSISEGNFMVAGEVNIYGPTEASIYAAY
Nearest Stachelhaus code(s):: Ala DVSNMAIIYK (88% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (4384..4787): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FSMTFDIAALELQALCGGEWNLYGPTETTVWSTV
Nearest Stachelhaus code(s):: Gly DILQLGLVWK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

LQ568_RS00940: Thr - X

Search NORINE for peptide: strict or relaxed

AMP-binding (512..919): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LATHFDFSVWEGNQIFGGEINMYGITETTVHVTY
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1609..2013): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LNPMFDVGSQEISLGVGGEVNAYGPTENSIASTC
Nearest Stachelhaus code(s):: Arg DVESIGAIAK (53% 8Å match)
Stachelhaus code match:: 80% (moderate)

LQ568_RS00955: mal

PKS_AT (4..229): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 56.3
inactive: 29.0
Methoxymalonyl-CoA: 14.2
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Methylmalonyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
CcpA	Catabolite control protein A
LexA variant 3	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
RpoN	Regulator of nitrogen assimilation and virulence
ToxT	Regulator of MSHA biosynthesis

NZ_JAJNPN010000001.1 - Region 3 - terpene

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Location: 331,507 - 352,247 nt. (total: 20,741 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

LQ568_RS01495: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

Transferases: aminotransferase

LQ568_RS01480: aminotransferase

smcogs: SMCOG1019: aminotransferase

Hydrolases: hydrolase

LQ568_RS01520: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002458.3	0.49	NRPS	alazopeptin	Streptacidiphilus griseoplanus
BGC0000885.3	0.47	other (other)	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0000846.5	0.44	other (other)	tabtoxin	Pseudomonas syringae
BGC0001374.5	0.42	other (other)	thienodolin	Streptomyces albogriseolus
BGC0001880.3	0.41	ribosomal	scytodecamide	Scytonema sp. UIC 10036
BGC0001488.3	0.38	other (other)	4-formylaminooxyvinylglycine	Pseudomonas fluorescens WH6
BGC0002285.2	0.35	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0001810.3	0.35	PKS	trehangelin	Polymorphospora rubra
BGC0000720.3	0.35	saccharide	tobramycin	Streptoalloteichus tenebrarius
BGC0001735.5	0.35	other (other)	pentostatine, vidarabine	Streptomyces antibioticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002458.3	0.49	NRPS	alazopeptin	Streptacidiphilus griseoplanus
BGC0000885.3	0.47	other (other)	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0000846.5	0.44	other (other)	tabtoxin	Pseudomonas syringae
BGC0001374.5	0.42	other (other)	thienodolin	Streptomyces albogriseolus
BGC0001880.3	0.41	ribosomal	scytodecamide	Scytonema sp. UIC 10036
BGC0001488.3	0.38	other (other)	4-formylaminooxyvinylglycine	Pseudomonas fluorescens WH6
BGC0002285.2	0.35	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0001810.3	0.35	PKS	trehangelin	Polymorphospora rubra
BGC0000720.3	0.35	saccharide	tobramycin	Streptoalloteichus tenebrarius
BGC0001735.5	0.35	other (other)	pentostatine, vidarabine	Streptomyces antibioticus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	C30 carotenoid	diapophytoene	C30	acyclic	none
triterpene		squalene	C30	acyclic	none
triterpene		PSPP	C30	acyclic	PP
tetraterpene	C40 carotenoid	phytoene	C40	acyclic	none
triterpene		hydroxysqualene	C30	acyclic	OH

Genes with terpene domains:

LQ568_RS01515: PT_phytoene_like

Domain 1 (3 - 242): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → diapophytoene; FPP → squalene; FPP → PSPP; GGPP → phytoene; PSPP → hydroxysqualene

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 20.47 out of 20.47

Confidence: strong

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 23.16 out of 26.33

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.88 out of 27.78

Confidence: medium

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.10 out of 26.85

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.27 out of 28.19

Confidence: medium

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 26.99 out of 35.63

Confidence: medium

Additional weak hits (5):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.61 out of 30.22

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.44 out of 31.73

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.16 out of 26.06

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.38 out of 21.84

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.91 out of 32.74

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
PP	Diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
NrtR	NAD synthesis repressor
RutR	Regulator of the pyrimidine and purine metabolism
VqsM	Regulator of quorum-sensing signalling systems
ZuR variant 1	Zinc-responsive repressor

NZ_JAJNPN010000010.1 - Region 1 - terpene

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Download region SVG

Location: 161,652 - 183,535 nt. (total: 21,884 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

LQ568_RS10050: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

Hydrolases: hydrolase

LQ568_RS10025: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002173.2	0.46	saccharide, terpene	fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol	Aspergillus fumigatus A1163
BGC0001535.3	0.42	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0000313.4	0.36	NRPS	beauvericin	Beauveria bassiana
BGC0002255.3	0.33	PKS	lijiquinone	Ascomycota sp. F53
BGC0000663.5	0.30	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0000686.3	0.30	terpene	helvolic acid	Aspergillus fumigatus Af293
BGC0001575.4	0.29	NRPS	PZN5, PZN6, PZN7, PZN9, PZN10, PZN11	Ruminococcus sp. 5_1_39BFAA
BGC0001338.4	0.28	PKS	citrinin	Monascus ruber
BGC0000154.4	0.28	PKS	stipitatic acid	Talaromyces stipitatus ATCC 10500
BGC0001739.3	0.28	other (other)	phosphonoacetic Acid	Streptomyces sp. NRRL F-525

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002173.2	0.46	saccharide, terpene	fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol	Aspergillus fumigatus A1163
BGC0001535.3	0.42	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0000313.4	0.36	NRPS	beauvericin	Beauveria bassiana
BGC0002255.3	0.33	PKS	lijiquinone	Ascomycota sp. F53
BGC0000663.5	0.30	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0000686.3	0.30	terpene	helvolic acid	Aspergillus fumigatus Af293
BGC0001575.4	0.29	NRPS	PZN5, PZN6, PZN7, PZN9, PZN10, PZN11	Ruminococcus sp. 5_1_39BFAA
BGC0001338.4	0.28	PKS	citrinin	Monascus ruber
BGC0000154.4	0.28	PKS	stipitatic acid	Talaromyces stipitatus ATCC 10500
BGC0001739.3	0.28	other (other)	phosphonoacetic Acid	Streptomyces sp. NRRL F-525

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	hopanoid		C30	hopanoid skeleton	unknown
triterpene	polypodane		C30	polypodane skeleton	unknown

Genes with terpene domains:

LQ568_RS10045: T2TS

Domain 1 (5 - 625): Type 2 terpene synthase

Subtype: Squalene substrate

Reactions:: squalene → hopanoid; squalene → polypodane

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.53 out of 26.06

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 26.30 out of 27.78

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.86 out of 27.78

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 28.19

Confidence: medium

Additional weak hits (5):

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.63 out of 25.75

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.14 out of 39.62

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.54 out of 26.06

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.10 out of 29.25

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.62 out of 21.55

Confidence: weak

Terpene

TFBS Finder

Glossary

No acronyms to display

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_JAJNPN010000012.1 - Region 1 - NRPS

Download region GenBank file

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Location: 88,938 - 116,911 nt. (total: 27,974 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase electron transfer oxidoreductase reductase

LQ568_RS10925: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

LQ568_RS10940: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

LQ568_RS10945: flavodoxin

smcogs: SMCOG1134: flavodoxin

LQ568_RS10950: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

LQ568_RS10965: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

Ligases: synthase

LQ568_RS10960: cobalamin synthesis protein/P47K family protein

smcogs: SMCOG1178: cobalamin synthesis protein/P47K family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.71	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.68	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0000342.4	0.68	NRPS	enniatin	Fusarium equiseti
BGC0001825.4	0.68	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001833.4	0.68	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.4	0.67	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.66	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.66	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.65	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0000307.4	0.65	NRPS	AbT1	Aureobasidium pullulans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.71	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.68	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0000342.4	0.68	NRPS	enniatin	Fusarium equiseti
BGC0001825.4	0.68	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001833.4	0.68	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.4	0.67	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.66	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.66	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.65	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0000307.4	0.65	NRPS	AbT1	Aureobasidium pullulans

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.55 out of 29.38

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.80 out of 27.78

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.40 out of 20.97

Confidence: medium

Additional weak hits (9):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.89 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.74 out of 32.74

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 23.23 out of 36.54

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.52 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.40 out of 26.06

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 23.04 out of 30.12

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.79 out of 20.01

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.84 out of 26.06

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 22.50 out of 35.63

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 88937 - 116911:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Glu - Leu)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

LQ568_RS11010: Glu - Leu

Search NORINE for peptide: strict or relaxed

AMP-binding (465..867): Glu

nrpys: Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: gln (Gln)

Stachelhaus prediction details:

Stachelhaus sequence:: LSLAFDASVKQADGLIGGETNVYGPTETCVDASV
Nearest Stachelhaus code(s):: Glu DAKDLGVVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1511..1908): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: TNTSFDAFMFDGMIMFGGELHMYGPSESTVFATY
Nearest Stachelhaus code(s):: Leu DAFMMGMVFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1	Ferric Uptake Regulator

NZ_JAJNPN010000013.1 - Region 1 - other

Download region GenBank file

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Location: 112,211 - 153,629 nt. (total: 41,419 nt) Show pHMM detection rules used

other: (Neocarzinostat or bcpB or frbD or mitE or prnB or CaiA or bacilysin or orf2_PTase)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

LQ568_RS11720: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

LQ568_RS11740: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

LQ568_RS11775: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

Transferases: aminotransferase transferase

LQ568_RS11725: aminotransferase

smcogs: SMCOG1019: aminotransferase

LQ568_RS11805: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

LQ568_RS11830: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

Lyases: dehydratase lyase

LQ568_RS11735: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

LQ568_RS11795: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

LQ568_RS11800: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Translocases: permease

LQ568_RS11630: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

LQ568_RS11765: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000888.5	0.97	other (other)	bacilysin	Bacillus sp. CS93
BGC0001184.4	0.97	other (other)	bacilysin	Bacillus velezensis FZB42
BGC0000898.5	0.56	saccharide	desosamine, pikromycin, neomethymycin, narbomycin	Streptomyces venezuelae
BGC0000773.3	0.55	saccharide	lipopolysaccharide	Escherichia coli
BGC0000790.3	0.54	saccharide	O-antigen	Escherichia coli
BGC0000794.5	0.53	saccharide	S-layer glycan	Geobacillus stearothermophilus
BGC0000791.3	0.53	saccharide	O-antigen	Cronobacter sakazakii
BGC0000795.3	0.52	saccharide	S-layer glycan	Aneurinibacillus thermoaerophilus
BGC0000899.4	0.52	saccharide	desosamine	Streptomyces narbonensis
BGC0001817.5	0.52	other (other)	vancosamine	Streptomyces sp. WAC2288

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000888.5	0.97	other (other)	bacilysin	Bacillus sp. CS93
BGC0001184.4	0.97	other (other)	bacilysin	Bacillus velezensis FZB42
BGC0000898.5	0.56	saccharide	desosamine, pikromycin, neomethymycin, narbomycin	Streptomyces venezuelae
BGC0000773.3	0.55	saccharide	lipopolysaccharide	Escherichia coli
BGC0000790.3	0.54	saccharide	O-antigen	Escherichia coli
BGC0000794.5	0.53	saccharide	S-layer glycan	Geobacillus stearothermophilus
BGC0000791.3	0.53	saccharide	O-antigen	Cronobacter sakazakii
BGC0000795.3	0.52	saccharide	S-layer glycan	Aneurinibacillus thermoaerophilus
BGC0000899.4	0.52	saccharide	desosamine	Streptomyces narbonensis
BGC0001817.5	0.52	other (other)	vancosamine	Streptomyces sp. WAC2288

Similar known clusters from MIBiG 4.0

Similar subclusters

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.48 out of 18.57

Confidence: strong

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.22 out of 18.46

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.67 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.85 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.63 out of 27.78

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.75 out of 29.38

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.27 out of 27.78

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.75 out of 28.19

Confidence: medium

Additional weak hits (7):

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.62 out of 32.93

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.37 out of 20.01

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.29 out of 36.54

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 26.15 out of 36.54

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 21.66 out of 30.97

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.32 out of 26.06

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.68 out of 33.14

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1	Ferric Uptake Regulator
MogR	Repressor of flagellar motility genes
RpoN	Regulator of nitrogen assimilation and virulence
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_JAJNPN010000015.1 - Region 1 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 93,026 - 116,214 nt. (total: 23,189 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

LQ568_RS13325: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

Lyases: cyclase

LQ568_RS13300: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000527.5	0.96	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000554.4	0.56	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000528.5	0.56	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000626.3	0.53	ribosomal	thuricin	Bacillus thuringiensis
BGC0000516.4	0.53	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000539.5	0.53	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0001210.5	0.52	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0001555.4	0.51	ribosomal	colicin V	Escherichia coli chi7122
BGC0001787.3	0.51	ribosomal	suicin 3908	Streptococcus suis
BGC0000525.5	0.51	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000527.5	0.96	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000554.4	0.56	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000528.5	0.56	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000626.3	0.53	ribosomal	thuricin	Bacillus thuringiensis
BGC0000516.4	0.53	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000539.5	0.53	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0001210.5	0.52	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0001555.4	0.51	ribosomal	colicin V	Escherichia coli chi7122
BGC0001787.3	0.51	ribosomal	suicin 3908	Streptococcus suis
BGC0000525.5	0.51	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for LQ568_RS13300

LQ568_RS13285

Leader:

MSQEAIIRSWKDPFSRENSTQNPAGNPFSELKEAQMDKLVGA

Core:

GDMEAACTFTLPGGGGVCTLTSECIC

Core with dehydrations:

GDMEAACysDhbFDhbLPGGGGVCysDhbLDhbDhaECysICys

antiSMASH-DB 4.0 matches for LQ568_RS13285

100.0%

NC_017912.1and 14 others:

NZ_CP007242.1 Lanthipeptides: KHU1_RS17410_lanthipeptideNZ_CP031424.1 Lanthipeptides: DXX91_RS18935_lanthipeptideNZ_CP032855.1 Lanthipeptides: D9C11_RS10440_lanthipeptideNZ_CP043809.1 Lanthipeptides: ETZ92_RS14260_lanthipeptideNZ_CP049904.1 Lanthipeptides: V753_RS18470_lanthipeptideNZ_CP053764.1 Lanthipeptides: HPQ66_RS18325_lanthipeptideNZ_CP061938.1 Lanthipeptides: IEN91_RS19800_lanthipeptideNZ_CP063768.1 Lanthipeptides: IM712_RS05205_lanthipeptideNZ_CP087137.1 Lanthipeptides: LOK79_RS18580_lanthipeptideNZ_CP092383.1 Lanthipeptides: MID02_RS19390_lanthipeptideNZ_JAEACM010000001.1 Lanthipeptides: I5F15_RS04355_lanthipeptideNZ_JAJNPN010000015.1 Lanthipeptides: LQ568_RS13285_lanthipeptideNZ_SDKF01000002.1 Lanthipeptides: EUA41_RS09950_lanthipeptideNZ_VDUT01000007.1 Lanthipeptides: FS412_RS14545_lanthipeptide

Lanthipeptides: MUS_RS20065_lanthipeptide

1

GDMEAACTFTLPGGGGVCTLTSECIC

26

GDMEAACTFTLPGGGGVCTLTSECIC

1

GDMEAACTFTLPGGGGVCTLTSECIC

26

96.2%

NZ_BORO01000007.1:

Lanthipeptides: KI343_RS07745_lanthipeptide

1

GDMEAACTFTLPGGGGVCTLTSECIC

26

GDMEAACT+TLPGGGGVCTLTSECIC

1

GDMEAACTWTLPGGGGVCTLTSECIC

26

92.3%

NZ_JALASB010000016.1and 3 others:

NZ_JALASR010000012.1 Lanthipeptides: MOD87_RS16305_lanthipeptideNZ_JALAUW010000005.1 Lanthipeptides: MOE83_RS03160_lanthipeptideNZ_JALAXQ010000010.1 Lanthipeptides: MOF24_RS12150_lanthipeptide

Lanthipeptides: MOD42_RS18070_lanthipeptide

1

GDMEAACTFTLPGGGGVCTLTSECIC

26

GDMEAACT+TLPGGGGVCT+TSECIC

1

GDMEAACTWTLPGGGGVCTITSECIC

26

with 98 more sequence matches

Only the first 10 are displayed here.

92.3%

NZ_KZ454939.1:

Lanthipeptides: CEF20_RS01155_lanthipeptide

1

GDMEAACTFTLPGGGGVCTLTSECIC

26

GDMEAACT+TLPGGGGVCT+TSECIC

1

GDMEAACTWTLPGGGGVCTVTSECIC

26

40.0%

NZ_CP047419.1and 3 others:

NZ_CP047419.1 Lanthipeptides: GTU71_RS12805_lanthipeptideNZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15590_lanthipeptideNZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15590_lanthipeptide

Lanthipeptides: GTU71_RS12805_lanthipeptide

8

TFTLPG----GGGVCTLTSEC

24

TFTL GG CTLT EC

5

TFTLSNVLGNQGGWCTLTVEC

25

40.0%

NZ_CP084530.1and 1 other:

NZ_CP084530.1 Lanthipeptides: LDO05_RS02075_lanthipeptide

Lanthipeptides: LDO05_RS02075_lanthipeptide

8

TFTLPG----GGGVCTLTSEC

24

TFTL GG CTLT EC

5

TFTLSNYLGNNGGWCTLTKEC

25

40.0%

NZ_LT985747.1and 1 other:

NZ_LT985747.1 Lanthipeptides: C8268_RS00165_lanthipeptide

Lanthipeptides: C8268_RS00165_lanthipeptide

8

TFTLP----GGGGVCTLTSEC

24

TFTL GG CTLT EC

5

TFTLSDYLGNKGGWCTLTKEC

25

39.3%

NZ_FOBE01000018.1:

Lanthipeptides: BMW61_RS13085_lanthipeptide

2

DMEAACTFTLPGGGGVCTLTSEC

24

+M AA L G CTLT EC

5

EMSAA----LGNRGSYCTLTKEC

23

36.7%

NZ_MJEJ02000054.1and 3 others:

NZ_MJEJ02000054.1 Lanthipeptides: BH683_RS28205_lanthipeptideNZ_QJSP01000005.1 Lanthipeptides: DFR67_RS09500_lanthipeptideNZ_QJSP01000005.1 Lanthipeptides: DFR67_RS09500_lanthipeptide

Lanthipeptides: BH683_RS28205_lanthipeptide

8

TFTLP----GGGGVCTLTSE

23

TFTL GG CTLT E

5

TFTLSDFLGNDGGWCTLTKE

24

35.3%

NZ_SDLS01000001.1:

Lanthipeptides: EIZ45_RS45960_lanthipeptide

2

DMEAACTFTLPGGGGVCTLTSECIC

26

D+ A T LP G +CT T EC C

10

DLAEARTAALPSSGYICTFTFECNC

34

34.6%

NZ_CP034669.1:

Lanthipeptides: EJ065_RS32040_lanthipeptide

15

GGVCTLTSECIC

26

G VCTLT+EC C

11

GYVCTLTTECGC

22

34.6%

NZ_CP035495.1and 1 other:

NZ_CP035495.1 Lanthipeptides: ET495_RS17535_lanthipeptide

Lanthipeptides: ET495_RS17535_lanthipeptide

9

FTLPGG---GGVCTLTSEC

24

+T+PG G CTL+ EC

2

WTIPGTSTIGRFCTLSWEC

20

34.6%

NZ_JALMDK010000017.1:

Lanthipeptides: allorf_059288_059443_lanthipeptide

14

GGGVCTLTSECIC

26

GG +CTLT EC C

3

GGYICTLTWECNC

15

MIBiG 4.0 matches for LQ568_RS13285

30.0%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

11

LPGGGGVCTLTSEC

24

L GG CTLT EC

12

LGNNGGWCTLTKEC

25

28.6%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

11

LPGGGGVCTLTSECI

25

L G CTLT EC+

10

LGNKGAYCTLTVECM

24

12.8%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

18

CTLTSEC

24

CTL+ EC

28

CTLSKEC

34

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.88 out of 27.78

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 16.62 out of 18.16

Confidence: strong

Additional weak hits (3):

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.98 out of 29.25

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 19.83 out of 30.11

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 23.50 out of 32.93

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

LQ568_RS13285 - Class II

Cleavage pHMM score: -2.00

RODEO score: 0

Monoisotopic mass: 2399.0 Da

Molecular weight: 2400.8 Da

Number of bridges: 3

Additional modifications: AviCys

Alternative weights: (assuming N unmodified Ser/Thr residues); 2418.8 Da N = 1

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria

NZ_JAJNPN010000017.1 - Region 1 - NRPS,betalactone,transAT-PKS

Download region GenBank file

Download region SVG

Location: 1 - 87,702 nt. (total: 87,702 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
betalactone: (HMGL-like and AMP-binding)
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

LQ568_RS13520: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

LQ568_RS13595: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

LQ568_RS13615: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

LQ568_RS13710: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

LQ568_RS13725: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

Transferases: acylase aminotransferase carboxylase transferase

LQ568_RS13530: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

LQ568_RS13550: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

LQ568_RS13560: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

LQ568_RS13575: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

LQ568_RS13620: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Lyases: hydratase

LQ568_RS13545: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase

LQ568_RS13500: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

LQ568_RS13505: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

LQ568_RS13525: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

LQ568_RS13540: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

LQ568_RS13580: 8-amino-7-oxononanoate synthase

smcogs: SMCOG1109: 8-amino-7-oxononanoate synthase

LQ568_RS13625: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

LQ568_RS13630: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

LQ568_RS13635: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001090.5	1.64	NRPS, PKS	bacillomycin D	Bacillus velezensis FZB42
BGC0001833.4	1.49	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	1.47	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001128.4	1.45	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	1.44	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	1.43	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001098.5	1.43	NRPS, PKS	iturin	Bacillus subtilis
BGC0002286.3	1.42	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	1.38	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001758.4	1.37	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001090.5	0.93	NRPS, PKS	bacillomycin D	Bacillus velezensis FZB42
BGC0001098.5	0.84	NRPS, PKS	iturin	Bacillus subtilis
BGC0000402.4	0.80	NRPS	paenilarvin A, paenilarvin B, paenilarvin C	Paenibacillus larvae subsp. larvae DSM 25430
BGC0001103.5	0.77	NRPS, PKS	mycosubtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001095.5	0.76	NRPS	fengycin	Bacillus velezensis FZB42
BGC0001833.4	0.75	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	0.74	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001128.4	0.73	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.73	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002075.3	0.73	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 20.32 out of 20.97

Confidence: strong

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 18.15 out of 18.46

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.29 out of 27.55

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.67 out of 26.06

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.83 out of 28.19

Confidence: medium

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.44 out of 32.93

Confidence: medium

Additional weak hits (7):

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.44 out of 20.47

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.74 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.46 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.66 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.52 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.06 out of 29.38

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.01 out of 24.78

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 87702:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Tyr) + (Ile) + (fatty_acid - mal - Asn - D-Tyr) + (D-Asn - Pro - Glu - D-Ser) + (Thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 27538:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Tyr) + (Ile)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 10452 - 87702:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (fatty_acid - mal - Asn - D-Tyr) + (D-Asn - Pro - Glu - D-Ser) + (Thr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

LQ568_RS13500: Tyr

Search NORINE for peptide: strict or relaxed

AMP-binding (178..570): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: TWRFFDGFVTSTIITLAGEANEYGPTENSVATTA
Nearest Stachelhaus code(s):: Tyr DGTITAEVAK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

LQ568_RS13505: Ile

Search NORINE for peptide: strict or relaxed

AMP-binding (473..866): Ile

nrpys: Ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: ile (Ile)

Stachelhaus prediction details:

Stachelhaus sequence:: LNSGFDAVTFEGFLYVGGEYNIYGPTENTTFSTF
Nearest Stachelhaus code(s):: Ile DAFFYGITFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

LQ568_RS13525: X

AMP-binding (12..445): X

nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: NNIVF-GCVLGAHGIMAGSTIAYGQTEASPVITQ
Nearest Stachelhaus code(s):: Z-ahmohOrn FGLHIASTCK (56% 8Å match); Ile DGLFIGIPVK (32% 8Å match)
Stachelhaus code match:: 60% (weak)

LQ568_RS13620: mal

PKS_AT (6..290): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 81.9
inactive: 31.2
Methoxymalonyl-CoA: 21.8
Methylmalonyl-CoA: 13.2
Propionyl-CoA: 12.9
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

LQ568_RS13625: fatty_acid - Asn

Search NORINE for peptide: strict or relaxed

CAL_domain (36..478): fatty_acid

minowa: fatty_acid

Prediction, score:

fatty_acid: 624.6
NH2: 18.6
shikimic_acid: 0.0
Acetyl-CoA: 0.0
AHBA: 0.0

AMP-binding (2956..3351): Asn

nrpys: Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: YWASFDLTVTSTKLIVGGEFNEYGPTEAVVGCMI
Nearest Stachelhaus code(s):: Asn DLTKIGEVGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

LQ568_RS13630: Tyr - Asn - Pro - Glu

Search NORINE for peptide: strict or relaxed

AMP-binding (268..662): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: SWKYFDAFILNGSTVVGGENNEYGPTENSVVSTF
Nearest Stachelhaus code(s):: Tyr DALSVGEVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1779..2174): Asn

nrpys: Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: YWASFDLTVTSTKLIVGGECNEYGPTETVVGCMI
Nearest Stachelhaus code(s):: Asn DLTKIGEVGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3286..3683): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: LDQAFDVCYQESFFITAGEHNHYGPSETHVVSTY
Nearest Stachelhaus code(s):: Pro DVQFIAHVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (4325..4732): Glu

nrpys: Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: gln (Gln)

Stachelhaus prediction details:

Stachelhaus sequence:: LGLAFDASVKQADGLIGGETNVYGPTETCVDASV
Nearest Stachelhaus code(s):: Glu DAKDLGVVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

LQ568_RS13635: Ser - Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (267..674): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWMTFDVSVWEWHFFASGEINLYGPTEATIDVSY
Nearest Stachelhaus code(s):: Ser DVWHFSLIDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1789..2188): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LNNHFDFSVWEGNQIFGGEINMYGITETTVHVTY
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
GnfM	Regulator of nitrogen-fixation genes
LexA variant 3	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
RpoN	Regulator of nitrogen assimilation and virulence
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_JAJNPN010000018.1 - Region 1 - transAT-PKS

Download region GenBank file

Download region SVG

Location: 1 - 80,922 nt. (total: 80,922 nt) Show pHMM detection rules used

Region on contig edge.

transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

LQ568_RS14020: 3-hydroxyisobutyrate dehydrogenase

smcogs: SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

LQ568_RS14045: NADH:flavin oxidoreductase/NADH oxidase

smcogs: SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

LQ568_RS14090: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

LQ568_RS14095: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

LQ568_RS14100: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

LQ568_RS14110: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

LQ568_RS14115: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

LQ568_RS14140: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

LQ568_RS14220: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

Transferases: acylase transferase

LQ568_RS13995: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

LQ568_RS14070: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: deacetylase hydrolase

LQ568_RS14000: acetylornithine deacetylase

smcogs: SMCOG1247: acetylornithine deacetylase

LQ568_RS14135: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

Lyases: hydratase

LQ568_RS14125: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase

LQ568_RS14085: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

LQ568_RS14105: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

LQ568_RS14120: hydroxymethylglutaryl-CoA synthase

smcogs: SMCOG1043: hydroxymethylglutaryl-CoA synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000176.5	0.73	PKS	difficidin	Bacillus velezensis FZB42
BGC0001164.3	0.62	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.61	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001254.3	0.61	PKS	ACT-Toxin II	Alternaria alternata
BGC0000174.5	0.58	PKS	bryostatin	Candidatus Endobugula sertula
BGC0002056.3	0.57	NRPS, PKS	peloruside A	sponge metagenome
BGC0001795.3	0.53	PKS	swinholide A	Nostoc sp. UHCC 0450
BGC0000067.5	0.53	PKS	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000205.3	0.52	PKS	bryostatin	Candidatus Endobugula sertula
BGC0001201.3	0.52	terpene	eremophilene	Sorangium cellulosum So ce56

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000176.5	0.73	PKS	difficidin	Bacillus velezensis FZB42
BGC0001164.3	0.62	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.61	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001254.3	0.61	PKS	ACT-Toxin II	Alternaria alternata
BGC0000174.5	0.58	PKS	bryostatin	Candidatus Endobugula sertula
BGC0002056.3	0.57	NRPS, PKS	peloruside A	sponge metagenome
BGC0001795.3	0.53	PKS	swinholide A	Nostoc sp. UHCC 0450
BGC0000067.5	0.53	PKS	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000205.3	0.52	PKS	bryostatin	Candidatus Endobugula sertula
BGC0001201.3	0.52	terpene	eremophilene	Sorangium cellulosum So ce56

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.22 out of 18.57

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.92 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.19 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.89 out of 27.78

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 23.96 out of 24.78

Confidence: strong

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.30 out of 25.31

Confidence: medium

Additional weak hits (9):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.08 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.45 out of 26.06

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.61 out of 30.25

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 21.46 out of 30.97

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.34 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.26 out of 26.06

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 22.13 out of 30.97

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 26.71 out of 30.97

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.89 out of 32.93

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 80922:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-ccmal - ccmal - ohmal - ccmal) + (ohmal - mal) + (Me-ccmal) + (mal)
Non-colinear ordering:: LQ568_RS14095 + LQ568_RS14100 + LQ568_RS14105 + LQ568_RS14110

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

LQ568_RS14070: mal

PKS_AT (4..281): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 87.7
inactive: 30.9
Methoxymalonyl-CoA: 29.3
Methylmalonyl-CoA: 21.7
Propionyl-CoA: 16.5
2-Methylbutyryl-CoA: 15.4
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

LQ568_RS14085: X

AMP-binding (15..363): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: ALLLHIGGINTAPATYGTEKQTYGLTELGIFSTK
Nearest Stachelhaus code(s):: 2,3-dohHda IGNPTGTIMK (74% 8Å match)
Stachelhaus code match:: 90% (moderate)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CatR	H2O2-responsive repressor
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 2	Repressor of DNA damage response
ToxT	Regulator of MSHA biosynthesis

NZ_JAJNPN010000002.1 - Region 1 - PKS-like

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Location: 1 - 39,591 nt. (total: 39,591 nt) Show pHMM detection rules used

Region on contig edge.

PKS-like: (t2pks2 or ksIII)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

LQ568_RS02160: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acyltransferase aminotransferase

LQ568_RS02115: aminotransferase

smcogs: SMCOG1019: aminotransferase

LQ568_RS02130: acyltransferase

smcogs: SMCOG1141: acyltransferase

Hydrolases: deacetylase

LQ568_RS02070: polysaccharide deacetylase

smcogs: SMCOG1235: polysaccharide deacetylase

Ligases: synthase

LQ568_RS02110: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Translocases: permease

LQ568_RS02155: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002276.2	0.55	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001928.2	0.50	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0002404.2	0.45	other (other)	falcarindiol	Solanum lycopersicum
BGC0002294.3	0.43	other (other)	streptozotocin	Streptomyces achromogenes subsp. streptozoticus
BGC0000205.3	0.43	PKS	bryostatin	Candidatus Endobugula sertula
BGC0002150.2	0.42	ribosomal	triculamin	Streptomyces triculaminicus
BGC0002151.2	0.42	ribosomal	alboverticillin	Streptomyces griseocarneus
BGC0001292.5	0.42	other (other)	A33853	Streptomyces sp. NRRL 12068
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000623.3	0.42	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002276.2	0.55	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001928.2	0.50	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0002404.2	0.45	other (other)	falcarindiol	Solanum lycopersicum
BGC0002294.3	0.43	other (other)	streptozotocin	Streptomyces achromogenes subsp. streptozoticus
BGC0000205.3	0.43	PKS	bryostatin	Candidatus Endobugula sertula
BGC0002150.2	0.42	ribosomal	triculamin	Streptomyces triculaminicus
BGC0002151.2	0.42	ribosomal	alboverticillin	Streptomyces griseocarneus
BGC0001292.5	0.42	other (other)	A33853	Streptomyces sp. NRRL 12068
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000623.3	0.42	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.50 out of 23.79

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.52 out of 26.06

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 25.91 out of 27.55

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.88 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.01 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.81 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.75 out of 27.78

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.83 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.27 out of 28.19

Confidence: medium

Additional weak hits (12):

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.59 out of 30.11

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.41 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.75 out of 26.06

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.28 out of 28.14

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.34 out of 30.25

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.97 out of 28.14

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.67 out of 26.06

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.28 out of 28.14

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.22 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.48 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.02 out of 28.14

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.32 out of 33.14

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM	Regulator of nitrogen-fixation genes
IolR	Regulator of the inositol catabolism
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_JAJNPN010000021.1 - Region 1 - HR-T2PKS

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Location: 1 - 29,526 nt. (total: 29,526 nt) Show pHMM detection rules used

Region on contig edge.

HR-T2PKS: (hr-t2pks-ksa and (t2fas or APE_KS2 or ketoacyl-synt))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

LQ568_RS15090: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Hydrolases: amidase

LQ568_RS15150: amidase

smcogs: SMCOG1105: amidase

Ligases: synthase

LQ568_RS15100: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000888.5	0.48	other (other)	bacilysin	Bacillus sp. CS93
BGC0000231.5	0.46	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0002404.2	0.46	other (other)	falcarindiol	Solanum lycopersicum
BGC0001987.2	0.46	PKS	koreenceine A, koreenceine B, koreenceine C, koreenceine D	Pseudomonas koreensis
BGC0001184.4	0.46	other (other)	bacilysin	Bacillus velezensis FZB42
BGC0001197.5	0.45	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000948.5	0.45	other (other)	α-galactosylceramide	Bacteroides fragilis NCTC 9343
BGC0000234.5	0.44	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000204.5	0.44	PKS	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200
BGC0000272.3	0.43	PKS	spore pigment	Streptomyces collinus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000888.5	0.48	other (other)	bacilysin	Bacillus sp. CS93
BGC0000231.5	0.46	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0002404.2	0.46	other (other)	falcarindiol	Solanum lycopersicum
BGC0001987.2	0.46	PKS	koreenceine A, koreenceine B, koreenceine C, koreenceine D	Pseudomonas koreensis
BGC0001184.4	0.46	other (other)	bacilysin	Bacillus velezensis FZB42
BGC0001197.5	0.45	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000948.5	0.45	other (other)	α-galactosylceramide	Bacteroides fragilis NCTC 9343
BGC0000234.5	0.44	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000204.5	0.44	PKS	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200
BGC0000272.3	0.43	PKS	spore pigment	Streptomyces collinus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.05 out of 20.97

Confidence: strong

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.63 out of 26.85

Confidence: strong

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16

Confidence: strong

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 18.15 out of 18.46

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.63 out of 27.78

Confidence: medium

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.58 out of 21.84

Confidence: medium

Additional weak hits (1):

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.41 out of 30.11

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MexT	Global virulence regulator
RpoN	Regulator of nitrogen assimilation and virulence
RutR	Regulator of the pyrimidine and purine metabolism
ToxT	Regulator of MSHA biosynthesis

NZ_JAJNPN010000024.1 - Region 1 - terpene-precursor

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Location: 49,345 - 70,235 nt. (total: 20,891 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: carboxylase

LQ568_RS16280: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase

LQ568_RS16310: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

LQ568_RS16315: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0000638.3	0.37	terpene	carotenoid	Pantoea ananatis
BGC0000640.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC404

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0000638.3	0.37	terpene	carotenoid	Pantoea ananatis
BGC0000640.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC404

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

LQ568_RS16310: PT_FPPS_like

Domain 1 (33 - 296): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.59 out of 30.25

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.14 out of 27.78

Confidence: medium

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.81 out of 29.25

Confidence: medium

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
SypG	Regulator of biofilm formation and host colonization

NZ_JAJNPN010000003.1 - Region 1 - NRP-metallophore,NRPS,RiPP-like

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Location: 32,786 - 84,578 nt. (total: 51,793 nt) Show pHMM detection rules used

NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase reductase

LQ568_RS02475: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

LQ568_RS02550: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

LQ568_RS02600: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

LQ568_RS02605: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

LQ568_RS02655: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acetyltransferase

LQ568_RS02650: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

Hydrolases: hydrolase

LQ568_RS02440: isochorismatase

smcogs: SMCOG1027: isochorismatase

LQ568_RS02535: isochorismatase

smcogs: SMCOG1027: isochorismatase

Isomerases: isomerase

LQ568_RS02545: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: ligase

LQ568_RS02530: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

LQ568_RS02540: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000616.4	2.41	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0001185.5	1.57	NRPS	bacillibactin	Bacillus velezensis FZB42
BGC0000309.5	1.07	NRPS	bacillibactin	Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5	1.04	NRPS	paenibactin	Paenibacillus elgii B69
BGC0002075.3	0.87	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0000343.5	0.86	NRPS	enterobactin	Pseudomonas sp. J465
BGC0001132.4	0.77	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.76	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.75	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.74	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000616.4	0.95	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0001185.5	0.92	NRPS	bacillibactin	Bacillus velezensis FZB42
BGC0000309.5	0.81	NRPS	bacillibactin	Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5	0.80	NRPS	paenibactin	Paenibacillus elgii B69
BGC0002075.3	0.74	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0000343.5	0.74	NRPS	enterobactin	Pseudomonas sp. J465
BGC0001132.4	0.71	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.70	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.70	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.62 out of 18.16

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 29.38 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.61 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 27.15 out of 29.38

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.87 out of 27.78

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.49 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.91 out of 29.38

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.52 out of 27.78

Confidence: medium

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.23 out of 21.55

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.11 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.89 out of 27.78

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.73 out of 28.19

Confidence: strong

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.18 out of 28.19

Confidence: medium

Additional weak hits (18):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.44 out of 31.73

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.84 out of 29.25

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.61 out of 32.74

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.12 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.52 out of 32.74

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.31 out of 29.38

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.58 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.08 out of 26.06

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.44 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.15 out of 26.06

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.10 out of 29.25

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.86 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.13 out of 26.06

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.99 out of 33.14

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 21.63 out of 30.12

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 32785 - 84578:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 32785 - 84522:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

LQ568_RS02530: Gly - Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (456..855): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FSMTFDISGLELQALVGGETNLYGPTETTIWSAA
Nearest Stachelhaus code(s):: Gly DILQLGLIWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1513..1929): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LSTHFDFSVWEGNQIFGGEVNMYGITETTVHVSY
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

LQ568_RS02540: diOH-Bz

Search NORINE for peptide: strict or relaxed

AMP-binding (31..435): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: SISLYPLSSPGGALQVGGAQQVFGMAEGLVNYTR
Nearest Stachelhaus code(s):: diOH-Bz PLPAQGVVNK (100% 8Å match); diOH-Bz or Sal PLPAQGVVNK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
ArcA	Repressor of carbon oxidation
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1	Ferric Uptake Regulator
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_JAJNPN010000043.1 - Region 1 - NRPS

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Location: 1 - 10,260 nt. (total: 10,260 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: ligase

LQ568_RS19300: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

LQ568_RS19305: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.71	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000396.5	0.71	NRPS	nodularin	Nostoc sp. 73.1
BGC0001261.3	0.70	NRPS	AM-toxin	Alternaria alternata
BGC0001135.5	0.69	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.69	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000342.4	0.68	NRPS	enniatin	Fusarium equiseti
BGC0001825.4	0.68	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001833.4	0.68	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001166.5	0.68	NRPS	HC-toxin	Alternaria jesenskae
BGC0000426.5	0.68	NRPS	sevadicin	Paenibacillus larvae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.71	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000396.5	0.71	NRPS	nodularin	Nostoc sp. 73.1
BGC0001261.3	0.70	NRPS	AM-toxin	Alternaria alternata
BGC0001135.5	0.69	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.69	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000342.4	0.68	NRPS	enniatin	Fusarium equiseti
BGC0001825.4	0.68	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001833.4	0.68	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001166.5	0.68	NRPS	HC-toxin	Alternaria jesenskae
BGC0000426.5	0.68	NRPS	sevadicin	Paenibacillus larvae

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 10260:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-X) + (Pro - Gln)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

LQ568_RS19300: X

AMP-binding (179..572): X

nrpys: Ala, Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: LNSSFDVTTFEGWLIIGGEWNGYGPTENTTFSTC
Nearest Stachelhaus code(s):: Ala or Val DVFWIGGTFK (97% 8Å match); Val DVFWIGGTFK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

LQ568_RS19305: Pro - Gln

Search NORINE for peptide: strict or relaxed

AMP-binding (469..866): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: LDQAFDVCYQESFFITAGEHNHYGPSETHVVSTY
Nearest Stachelhaus code(s):: Pro DVQFIAHVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1500..1901): Gln

nrpys: Gln

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: glu (Glu)

Stachelhaus prediction details:

Stachelhaus sequence:: FSLTFDASIWEWHFFAGGETNSYGPTEATVEAAY
Nearest Stachelhaus code(s):: Gln DAWHFGSVEK (100% 8Å match); Glu DAWHFGSVEK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

NZ_JAJNPN010000045.1 - Region 1 - NRPS

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Location: 1 - 8,995 nt. (total: 8,995 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: ligase

LQ568_RS19330: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

LQ568_RS19335: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

LQ568_RS19755: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.71	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001261.3	0.70	NRPS	AM-toxin	Alternaria alternata
BGC0000342.4	0.68	NRPS	enniatin	Fusarium equiseti
BGC0001135.5	0.68	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.68	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001166.5	0.68	NRPS	HC-toxin	Alternaria jesenskae
BGC0001833.4	0.68	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.68	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0002286.3	0.67	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.67	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.71	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001261.3	0.70	NRPS	AM-toxin	Alternaria alternata
BGC0000342.4	0.68	NRPS	enniatin	Fusarium equiseti
BGC0001135.5	0.68	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.68	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001166.5	0.68	NRPS	HC-toxin	Alternaria jesenskae
BGC0001833.4	0.68	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.68	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0002286.3	0.67	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.67	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 8995:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Val) + (Asp)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

LQ568_RS19755: Asp

Search NORINE for peptide: strict or relaxed

AMP-binding (437..839): Asp

nrpys: Asp

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asp (Asp)

Stachelhaus prediction details:

Stachelhaus sequence:: YWFSFDLGYTAPKLVLGGEINHYGPTETTIGAIA
Nearest Stachelhaus code(s):: Asp DLTKVGHIGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

LQ568_RS19330: Val

Search NORINE for peptide: strict or relaxed

AMP-binding (470..864): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: LHSGFDAGTFEGWLIIGGDWNGYGPTENTTFSTS
Nearest Stachelhaus code(s):: Val DAFWIGGTFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

NZ_JAJNPN010000005.1 - Region 1 - transAT-PKS

Download region GenBank file

Download region SVG

Location: 57,645 - 145,875 nt. (total: 88,231 nt) Show pHMM detection rules used

transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

LQ568_RS05095: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

LQ568_RS05105: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

LQ568_RS05110: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

LQ568_RS05120: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

LQ568_RS05155: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Transferases: acylase kinase

LQ568_RS04990: PfkB domain protein

smcogs: SMCOG1276: PfkB domain protein

LQ568_RS05090: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: deacetylase deformylase hydrolase phosphatase

LQ568_RS05070: hydrolase

smcogs: SMCOG1179: hydrolase

LQ568_RS05075: peptide deformylase

smcogs: SMCOG1275: peptide deformylase

LQ568_RS05135: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

LQ568_RS05165: polysaccharide deacetylase

smcogs: SMCOG1235: polysaccharide deacetylase

LQ568_RS05195: inositol monophosphatase

smcogs: SMCOG1207: inositol monophosphatase

Ligases: synthase

LQ568_RS05100: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

LQ568_RS05145: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000181.5	0.88	PKS	macrolactin H	Bacillus velezensis FZB42
BGC0001383.3	0.88	PKS	macrolactin H, macrolactin B, macrolactin 1c, macrolactin E	Jeotgalibacillus marinus
BGC0001534.3	0.70	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001276.3	0.64	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.64	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001275.3	0.64	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0001284.4	0.63	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001254.3	0.62	PKS	ACT-Toxin II	Alternaria alternata
BGC0001164.3	0.61	PKS	1-heptadecene	Cyanothece sp. PCC 7822

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000181.5	0.88	PKS	macrolactin H	Bacillus velezensis FZB42
BGC0001383.3	0.88	PKS	macrolactin H, macrolactin B, macrolactin 1c, macrolactin E	Jeotgalibacillus marinus
BGC0001534.3	0.70	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001276.3	0.64	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.64	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001275.3	0.64	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0001284.4	0.63	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001254.3	0.62	PKS	ACT-Toxin II	Alternaria alternata
BGC0001164.3	0.61	PKS	1-heptadecene	Cyanothece sp. PCC 7822

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.63 out of 27.78

Confidence: strong

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.94 out of 21.55

Confidence: medium

Additional weak hits (8):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.30 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.56 out of 29.38

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.27 out of 30.22

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.65 out of 29.25

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.35 out of 26.33

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.20 out of 31.73

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.94 out of 29.65

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.99 out of 33.14

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 57644 - 145875:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (ohmal - ccmal - ccmal) + (ccmal) + (ccmal - mal) + (ccmal - mal) + (ohmal) + (ohmal - mal)
Non-colinear ordering:: LQ568_RS05095 + LQ568_RS05100 + LQ568_RS05105 + LQ568_RS05110 + LQ568_RS05115 + LQ568_RS05120 + LQ568_RS19785

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

LQ568_RS05090: mal

PKS_AT (4..282): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 92.6
inactive: 32.0
Methoxymalonyl-CoA: 28.0
Methylmalonyl-CoA: 20.8
Propionyl-CoA: 17.4
fatty_acid: 13.9
trans-1,2-CPDA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ToxT	Regulator of MSHA biosynthesis

NZ_JAJNPN010000005.1 - Region 2 - NRPS,T3PKS,transAT-PKS

Download region GenBank file

Download region SVG

Location: 368,599 - 405,834 nt. (total: 37,236 nt) Show pHMM detection rules used

Region on contig edge.

transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

LQ568_RS06345: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

Transferases: acylase

LQ568_RS06405: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

LQ568_RS06410: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

LQ568_RS06415: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: hydrolase

LQ568_RS06325: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

LQ568_RS06400: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

Lyases: hydratase

LQ568_RS06430: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

LQ568_RS06435: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase

LQ568_RS06350: 8-amino-7-oxononanoate synthase

smcogs: SMCOG1109: 8-amino-7-oxononanoate synthase

LQ568_RS06425: hydroxymethylglutaryl-CoA synthase

smcogs: SMCOG1043: hydroxymethylglutaryl-CoA synthase

LQ568_RS06440: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.99	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.94	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.91	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.91	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.90	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.90	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.89	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001275.3	0.87	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001758.4	0.86	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001244.3	0.86	PKS	(-)-Mellein	Parastagonospora nodorum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.66	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.65	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.64	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.64	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.64	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.63	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.63	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001275.3	0.63	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001758.4	0.62	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001244.3	0.62	PKS	(-)-Mellein	Parastagonospora nodorum

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 24.56 out of 29.25

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.78 out of 20.97

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.62 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.14 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.60 out of 26.06

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.59 out of 30.25

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.30 out of 24.78

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.14 out of 18.16

Confidence: strong

Additional weak hits (9):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.51 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.96 out of 26.06

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.16 out of 32.74

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.22 out of 28.14

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.08 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.45 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.67 out of 26.06

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 26.07 out of 39.62

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.67 out of 26.06

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 2, location 368598 - 405834:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (fatty_acid - Gly - ccmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

LQ568_RS06405: mal

PKS_AT (4..285): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 100.0
inactive: 46.8
Methoxymalonyl-CoA: 38.9
Methylmalonyl-CoA: 25.3
Propionyl-CoA: 23.1
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

LQ568_RS06410: mal

PKS_AT (7..293): mal

ATSignature: (unknown)

No matches above 50%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 36.5
inactive: 26.2
Methoxymalonyl-CoA: 14.3
Benzoyl-CoA: 13.9
Methylmalonyl-CoA: 9.2
Isobutyryl-CoA: 8.8
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

LQ568_RS06415: mal

PKS_AT (4..282): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 87.4
inactive: 28.2
Methoxymalonyl-CoA: 23.4
Methylmalonyl-CoA: 10.9
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

LQ568_RS06440: fatty_acid - Gly

Search NORINE for peptide: strict or relaxed

CAL_domain (74..476): fatty_acid

minowa: fatty_acid

Prediction, score:

fatty_acid: 26.0
NH2: 9.4
shikimic_acid: 0.0
Acetyl-CoA: 0.0
AHBA: 0.0

AMP-binding (1145..1540): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FSMTFDIAALELQALCGGEWNMFGPTETTIWSAV
Nearest Stachelhaus code(s):: Gly DILQLGMIWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
LexA variant 2	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
SypG	Regulator of biofilm formation and host colonization
ToxT	Regulator of MSHA biosynthesis

NZ_JAJNPN010000006.1 - Region 1 - NRPS,transAT-PKS-like

Download region GenBank file

Download region SVG

Location: 1 - 67,732 nt. (total: 67,732 nt) Show pHMM detection rules used

Region on contig edge.

transAT-PKS-like: cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS) and not PKS_AT)
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

LQ568_RS06450: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

LQ568_RS06470: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Hydrolases: protease

LQ568_RS06490: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Ligases: ligase synthase

LQ568_RS06455: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

LQ568_RS06460: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

LQ568_RS06465: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001089.5	0.53	NRPS, PKS	bacillaene	Bacillus velezensis FZB42
BGC0001160.5	0.50	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.50	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002631.2	0.41	ribosomal	Myxarylin	Pyxidicoccus fallax
BGC0000174.5	0.40	PKS	bryostatin	Candidatus Endobugula sertula
BGC0001310.5	0.37	PKS	naringenin	Streptomyces clavuligerus ATCC 27064
BGC0001050.5	0.36	NRPS, PKS	thalassospiramide A	Tistrella bauzanensis
BGC0002056.3	0.34	NRPS, PKS	peloruside A	sponge metagenome
BGC0001109.4	0.34	NRPS, PKS	pederin	unidentified unclassified sequences.
BGC0002127.3	0.33	PKS	flaviolin, 1,3,6,8-tetrahydroxynaphthalene	Streptomyces coelicolor A3(2)

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001089.5	0.65	NRPS, PKS	bacillaene	Bacillus velezensis FZB42
BGC0001273.3	0.61	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.61	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001275.3	0.61	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0000174.5	0.60	PKS	bryostatin	Candidatus Endobugula sertula
BGC0001160.5	0.59	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.59	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001284.4	0.58	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002631.2	0.53	ribosomal	Myxarylin	Pyxidicoccus fallax
BGC0001310.5	0.50	PKS	naringenin	Streptomyces clavuligerus ATCC 27064

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.31 out of 25.88

Confidence: medium

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.47 out of 21.55

Confidence: strong

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 22.51 out of 24.78

Confidence: strong

Additional weak hits (3):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.04 out of 30.25

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.39 out of 30.25

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.54 out of 36.54

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 67732:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ohmal - mal) + (ccmal - mal - ohmal - mal) + (Me-ccmal - ohmal) + (Ala - ccmal - ccmal - Me-ccmal) + (mal - mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

LQ568_RS06460: Ala

Search NORINE for peptide: strict or relaxed

AMP-binding (492..896): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: TFLTFDVSISEGNFMVAGEENIYGPTETSIYAAY
Nearest Stachelhaus code(s):: Ala DVSNMAIIYK (88% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
LexA variant 2	Repressor of DNA damage response
PsrA	Oleic acid responsive regulator

NZ_JAJNPN010000009.1 - Region 1 - NRPS

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Location: 185,851 - 211,054 nt. (total: 25,204 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

LQ568_RS08950: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

Transferases: PPTase aminotransferase

LQ568_RS09030: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

LQ568_RS09035: aminotransferase

smcogs: SMCOG1019: aminotransferase

Hydrolases: esterase

LQ568_RS09040: thioesterase

smcogs: SMCOG1004: thioesterase

Ligases: ligase

LQ568_RS09045: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

LQ568_RS09050: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001132.4	0.67	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.67	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001833.4	0.67	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002286.3	0.66	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.66	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.66	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.4	0.65	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.63	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0000357.5	0.63	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0002135.2	0.63	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001132.4	0.67	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.67	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001833.4	0.67	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002286.3	0.66	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.66	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.66	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.4	0.65	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.63	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0000357.5	0.63	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0002135.2	0.63	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.42 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.88 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.41 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.76 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.50 out of 27.78

Confidence: medium

Additional weak hits (6):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.88 out of 31.73

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.92 out of 26.06

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.35 out of 30.25

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 21.56 out of 31.73

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.99 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.38 out of 26.06

Confidence: weak

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 185850 - 211054:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Leu)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

LQ568_RS09045: Leu

Search NORINE for peptide: strict or relaxed

AMP-binding (469..867): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: LHVSFDAFTFDAFALFGGEINCYGPTEGTVFATA
Nearest Stachelhaus code(s):: Leu DAFFLGCVFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis