Select genomic region:
Overview
1.1
7.1
7.2
7.3
8.1
10.1
11.1
13.1
15.1
16.1
18.1
20.1
23.1
29.1
43.1
44.1
46.1
46.2
51.1
54.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_JAJNPN010000053.1 (Bacillus amyloliquefaciens)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | RiPP-like | 1 | 6,569 |

NZ_JAJNPN010000001.1 (Bacillus amyloliquefaciens)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 7.1 | lanthipeptide-class-ii | 94,100 | 122,989 |
Region 7.2 | NRPS,transAT-PKS,T3PKS | 145,967 | 263,908 | Low | bacillaene | NRPS:Type I+PKS:Type I
Region 7.3 | terpene | 331,507 | 352,247 |

NZ_JAJNPN010000010.1 (Bacillus amyloliquefaciens)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 8.1 | terpene | 161,652 | 183,535 |

NZ_JAJNPN010000012.1 (Bacillus amyloliquefaciens)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 10.1 | NRPS | 88,938 | 116,911 | Low | surfactin | NRPS:Type I

NZ_JAJNPN010000013.1 (Bacillus amyloliquefaciens)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 11.1 | other | 112,211 | 153,629 | High | bacilysin | other:other

NZ_JAJNPN010000015.1 (Bacillus amyloliquefaciens)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 13.1 | lanthipeptide-class-ii | 93,026 | 116,214 | High | mersacidin | ribosomal:RiPP:Lanthipeptide

NZ_JAJNPN010000017.1 (Bacillus amyloliquefaciens)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 15.1 | NRPS,betalactone,transAT-PKS | 1 | 87,702 | High | fengycin | NRPS:Type I

NZ_JAJNPN010000018.1 (Bacillus amyloliquefaciens)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 16.1 | transAT-PKS | 1 | 80,922 | High | difficidin | PKS

NZ_JAJNPN010000002.1 (Bacillus amyloliquefaciens)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 18.1 | PKS-like | 1 | 39,591 |  |

NZ_JAJNPN010000021.1 (Bacillus amyloliquefaciens)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 20.1 | HR-T2PKS | 1 | 29,526 |

NZ_JAJNPN010000024.1 (Bacillus amyloliquefaciens)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 23.1 | terpene-precursor | 49,345 | 70,235 |

NZ_JAJNPN010000003.1 (Bacillus amyloliquefaciens)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 29.1 | NRP-metallophore,NRPS,RiPP-like | 32,786 | 84,578 | High | bacillibactin | NRPS:Type I

NZ_JAJNPN010000043.1 (Bacillus amyloliquefaciens)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 43.1 | NRPS | 1 | 10,260 |  |

NZ_JAJNPN010000045.1 (Bacillus amyloliquefaciens)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 44.1 | NRPS | 1 | 8,995 |  |

NZ_JAJNPN010000005.1 (Bacillus amyloliquefaciens)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 46.1 | transAT-PKS | 57,645 | 145,875 | High | macrolactin H | PKS
Region 46.2 | transAT-PKS,T3PKS,NRPS | 368,599 | 405,834 | Medium | bacillaene | NRPS:Type I+PKS:Type I

NZ_JAJNPN010000006.1 (Bacillus amyloliquefaciens)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 51.1 | transAT-PKS-like,NRPS | 1 | 67,732 | Low | bacillaene | NRPS:Type I+PKS:Type I

NZ_JAJNPN010000009.1 (Bacillus amyloliquefaciens)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 54.1 | NRPS | 185,851 | 211,054 | Low | surfactin | NRPS:Type I

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | RiPP-like | 1 | 6,569 |
Region 7.1 | lanthipeptide-class-ii | 94,100 | 122,989 |
Region 7.2 | NRPS,transAT-PKS,T3PKS | 145,967 | 263,908 | Low | bacillaene | NRPS:Type I+PKS:Type I
Region 7.3 | terpene | 331,507 | 352,247 |
Region 8.1 | terpene | 161,652 | 183,535 |
Region 10.1 | NRPS | 88,938 | 116,911 | Low | surfactin | NRPS:Type I
Region 11.1 | other | 112,211 | 153,629 | High | bacilysin | other:other
Region 13.1 | lanthipeptide-class-ii | 93,026 | 116,214 | High | mersacidin | ribosomal:RiPP:Lanthipeptide
Region 15.1 | NRPS,betalactone,transAT-PKS | 1 | 87,702 | High | fengycin | NRPS:Type I
Region 16.1 | transAT-PKS | 1 | 80,922 | High | difficidin | PKS
Region 18.1 | PKS-like | 1 | 39,591 |  |
Region 20.1 | HR-T2PKS | 1 | 29,526 |
Region 23.1 | terpene-precursor | 49,345 | 70,235 |
Region 29.1 | NRP-metallophore,NRPS,RiPP-like | 32,786 | 84,578 | High | bacillibactin | NRPS:Type I
Region 43.1 | NRPS | 1 | 10,260 |  |
Region 44.1 | NRPS | 1 | 8,995 |  |
Region 46.1 | transAT-PKS | 57,645 | 145,875 | High | macrolactin H | PKS
Region 46.2 | transAT-PKS,T3PKS,NRPS | 368,599 | 405,834 | Medium | bacillaene | NRPS:Type I+PKS:Type I
Region 51.1 | transAT-PKS-like,NRPS | 1 | 67,732 | Low | bacillaene | NRPS:Type I+PKS:Type I
Region 54.1 | NRPS | 185,851 | 211,054 | Low | surfactin | NRPS:Type I

No secondary metabolite regions were found in these records:
  NZ_JAJNPN010000054.1 (Bacillus amyloliquefaciens)
  NZ_JAJNPN010000055.1 (Bacillus amyloliquefaciens)
  NZ_JAJNPN010000056.1 (Bacillus amyloliquefaciens)
  NZ_JAJNPN010000058.1 (Bacillus amyloliquefaciens)
  NZ_JAJNPN010000059.1 (Bacillus amyloliquefaciens)
  NZ_JAJNPN010000011.1 (Bacillus amyloliquefaciens)
  NZ_JAJNPN010000014.1 (Bacillus amyloliquefaciens)
  NZ_JAJNPN010000016.1 (Bacillus amyloliquefaciens)
  NZ_JAJNPN010000019.1 (Bacillus amyloliquefaciens)
  NZ_JAJNPN010000020.1 (Bacillus amyloliquefaciens)
  NZ_JAJNPN010000022.1 (Bacillus amyloliquefaciens)
  NZ_JAJNPN010000023.1 (Bacillus amyloliquefaciens)
  NZ_JAJNPN010000025.1 (Bacillus amyloliquefaciens)
  NZ_JAJNPN010000026.1 (Bacillus amyloliquefaciens)
  NZ_JAJNPN010000027.1 (Bacillus amyloliquefaciens)
  NZ_JAJNPN010000028.1 (Bacillus amyloliquefaciens)
  NZ_JAJNPN010000029.1 (Bacillus amyloliquefaciens)
  NZ_JAJNPN010000030.1 (Bacillus amyloliquefaciens)
  NZ_JAJNPN010000031.1 (Bacillus amyloliquefaciens)
  NZ_JAJNPN010000032.1 (Bacillus amyloliquefaciens)
  NZ_JAJNPN010000033.1 (Bacillus amyloliquefaciens)
  NZ_JAJNPN010000034.1 (Bacillus amyloliquefaciens)
  NZ_JAJNPN010000035.1 (Bacillus amyloliquefaciens)
  NZ_JAJNPN010000036.1 (Bacillus amyloliquefaciens)
  NZ_JAJNPN010000037.1 (Bacillus amyloliquefaciens)
  NZ_JAJNPN010000038.1 (Bacillus amyloliquefaciens)
  NZ_JAJNPN010000039.1 (Bacillus amyloliquefaciens)
  NZ_JAJNPN010000004.1 (Bacillus amyloliquefaciens)
  NZ_JAJNPN010000040.1 (Bacillus amyloliquefaciens)
  NZ_JAJNPN010000042.1 (Bacillus amyloliquefaciens)
  NZ_JAJNPN010000046.1 (Bacillus amyloliquefaciens)
  NZ_JAJNPN010000048.1 (Bacillus amyloliquefaciens)
  NZ_JAJNPN010000049.1 (Bacillus amyloliquefaciens)
  NZ_JAJNPN010000051.1 (Bacillus amyloliquefaciens)
  NZ_JAJNPN010000052.1 (Bacillus amyloliquefaciens)
  NZ_JAJNPN010000007.1 (Bacillus amyloliquefaciens)
  NZ_JAJNPN010000008.1 (Bacillus amyloliquefaciens)

Compact view
NZ_JAJNPN010000053.1 - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 6,569 nt. (total: 6,569 nt) Show pHMM detection rules used
Region on contig edge.
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000617.5 |  | 0.50 | ribosomal | coagulin | Bacillus coagulans
BGC0002579.2 |  | 0.49 | ribosomal | carnobacteriocin XY | Carnobacterium maltaromaticum
BGC0000558.5 |  | 0.49 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000624.3 |  | 0.47 | ribosomal | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0000619.3 |  | 0.46 | ribosomal | gassericin T | Lactobacillus gasseri
BGC0001602.3 |  | 0.46 | ribosomal | gassericin-T | Lactobacillus gasseri
BGC0001388.3 |  | 0.46 | ribosomal | gassericin E | Lactobacillus gasseri
BGC0002577.2 |  | 0.44 | ribosomal | lactococcin G | Lactococcus lactis
BGC0001862.4 |  | 0.41 | ribosomal | pallidocin | Aeribacillus pallidus
BGC0002674.2 |  | 0.40 | ribosomal | enterocin F4-9 | Enterococcus faecalis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000617.5 |  | 0.50 | ribosomal | coagulin | Bacillus coagulans
BGC0002579.2 |  | 0.49 | ribosomal | carnobacteriocin XY | Carnobacterium maltaromaticum
BGC0000558.5 |  | 0.49 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000624.3 |  | 0.47 | ribosomal | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0000619.3 |  | 0.46 | ribosomal | gassericin T | Lactobacillus gasseri
BGC0001602.3 |  | 0.46 | ribosomal | gassericin-T | Lactobacillus gasseri
BGC0001388.3 |  | 0.46 | ribosomal | gassericin E | Lactobacillus gasseri
BGC0002577.2 |  | 0.44 | ribosomal | lactococcin G | Lactococcus lactis
BGC0001862.4 |  | 0.41 | ribosomal | pallidocin | Aeribacillus pallidus
BGC0002674.2 |  | 0.40 | ribosomal | enterocin F4-9 | Enterococcus faecalis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
No hits above weak threshold.
Weak hits (3):
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.53 out of 33.73
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 24.12 out of 36.53
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.37 out of 30.98
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---

NZ_JAJNPN010000001.1 - Region 1 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 94,100 - 122,989 nt. (total: 28,890 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: cyclase
LQ568_RS00585: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

LQ568_RS00605: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000554.4 |  | 0.56 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000516.4 |  | 0.53 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000626.3 |  | 0.52 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000528.5 |  | 0.51 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001555.4 |  | 0.51 | ribosomal | colicin V | Escherichia coli chi7122
BGC0001210.5 |  | 0.51 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000590.5 |  | 0.50 | ribosomal | microcin N | Escherichia coli
BGC0001311.5 |  | 0.50 | ribosomal | flavecins | Ruminococcus flavefaciens FD-1
BGC0000539.5 |  | 0.50 | ribosomal | nukacin ISK-1 | Staphylococcus warneri
BGC0000527.5 |  | 0.49 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000554.4 |  | 0.56 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000516.4 |  | 0.53 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000626.3 |  | 0.52 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000528.5 |  | 0.51 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001555.4 |  | 0.51 | ribosomal | colicin V | Escherichia coli chi7122
BGC0001210.5 |  | 0.51 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000590.5 |  | 0.50 | ribosomal | microcin N | Escherichia coli
BGC0001311.5 |  | 0.50 | ribosomal | flavecins | Ruminococcus flavefaciens FD-1
BGC0000539.5 |  | 0.50 | ribosomal | nukacin ISK-1 | Staphylococcus warneri
BGC0000527.5 |  | 0.49 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for LQ568_RS00585

LQ568_RS00520
Leader:
MCKLCGPKKVIVTETGFGA
Core:
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K V R L D A R V Q I Y
Core with dehydrations:
V F H P Cys P N Cys K Dhb G Dhb D L Dhb P V I K R L E R M V Q D A K V R L D A R V Q I Y

#### antiSMASH-DB 4.0 matches for LQ568_RS00520

100.0%
NZ_CP023075.1 and 7 others:
NZ_CP035393.1 Lanthipeptides: ES966_RS21105_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19665_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17705_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03370_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01895_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00520_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122700_lanthipeptide
Lanthipeptides: CK238_RS20695_lanthipeptide
1
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K V R L D A R V Q I Y
39
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K V R L D A R V Q I Y
1
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K V R L D A R V Q I Y
39
92.3%
NZ_CP044444.1:
Lanthipeptides: F7V86_RS20970_lanthipeptide
1
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K V R L D A R V
36
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K V R L D A R V
1
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K V R L D A R V
36
89.7%
NC_023073.1 and 25 others:
NZ_CP010556.1 Lanthipeptides: SB45_RS19805_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19795_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20400_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22075_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS21000_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21480_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19740_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS19585_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20470_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21110_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20035_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16480_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06705_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18975_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06485_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16830_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06200_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12895_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06150_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06335_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11720_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS03045_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19745_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS19365_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18850_lanthipeptide
Lanthipeptides: U722_RS20005_lanthipeptide
1
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K V R L D A R V
36
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K R L D A R V
1
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K A R L D A R V
36
with 3 more sequence matches
87.2%
NZ_CP025341.1:
Lanthipeptides: CXR48_RS19565_lanthipeptide
1
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K V R L D A R V
36
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K R L D R V
1
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K A R L D L R V
36
20.5%
NC_015600.1 and 17 others:
NZ_AP020310.1 Lanthipeptides: SAGCMC97051_RS07300_lanthipeptide NZ_ATVP01000001.1 Lanthipeptides: G574_RS11150_lanthipeptide NZ_BCFB01000042.1 Lanthipeptides: GOZ36_RS07980_lanthipeptide NZ_CP024974.1 Lanthipeptides: CVO91_RS06555_lanthipeptide NZ_CP068708.1 Lanthipeptides: JM964_RS04040_lanthipeptide NZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptide NZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptide NZ_FIKS01000005.1 Lanthipeptides: A0525_RS10015_lanthipeptide NZ_GL636070.1 Lanthipeptides: HMPREF9171_RS106200_lanthipeptide NZ_JADPLU010000018.1 Lanthipeptides: I4V82_RS09545_lanthipeptide NZ_JAIMDQ010000006.1 Lanthipeptides: K6V44_RS04045_lanthipeptide NZ_JAKVIE010000017.1 Lanthipeptides: MK857_RS08340_lanthipeptide NZ_JAMDIB010000004.1 Lanthipeptides: M5P35_RS04030_lanthipeptide NZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptide NZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptide NZ_LR594050.1 Lanthipeptides: FGL20_RS03485_lanthipeptide NZ_SSXN01000004.1 Lanthipeptides: FAJ36_RS04715_lanthipeptide
Lanthipeptides: SGPB_RS10680_lanthipeptide
6
P N C K T G T D L T P V I K
19
P C K T G +T I K
9
P G C K T G I L M T C A I K
22
20.5%
NZ_CP059471.1 and 3 others:
NZ_FNZW01000001.1 Lanthipeptides: BMZ61_RS02110_lanthipeptide NZ_FOYC01000001.1 Lanthipeptides: BMZ88_RS03370_lanthipeptide NZ_KE384124.1 Lanthipeptides: G597_RS0106700_lanthipeptide
Lanthipeptides: H1R75_RS06635_lanthipeptide
6
P N C K T G T D L T P V I K
19
P C K T G +T I K
9
P G C K T G A L M T C P I K
22

#### MIBiG 4.0 matches for LQ568_RS00520

12.8%
BGC0000535.4 (ADJ56352.1):
Lanthipeptide: nisin A
6
P N C K T G
11
P C K T G
9
P G C K T G
14
LQ568_RS00590
Leader:
MKKDFQALTPMTEEELKNLAGG
Core:
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
Core with dehydrations:
Dha D A Dhb P M Dhb V Dhb P Dhb Dhb I Dhb I P I Dha L A G Cys P Dhb Dhb K Cys A Dha I V Dha P Cys N D

#### antiSMASH-DB 4.0 matches for LQ568_RS00590

100.0%
NC_023073.1 and 71 others:
NC_023073.1 Lanthipeptides: U722_RS19995_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide
Lanthipeptides: U722_RS19995_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
97.2%
NC_023073.1 and 71 others:
NC_023073.1 Lanthipeptides: U722_RS19990_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide
Lanthipeptides: U722_RS19990_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S+A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
94.4%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10245_lanthipeptide
Lanthipeptides: J7E20_RS10245_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S D A P M T+T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S D A A P M T I T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
with 60 more sequence matches
Only the first 10 are displayed here.
66.7%
NZ_JAMDLZ010000027.1:
Lanthipeptides: M5W82_RS15520_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T+T I P I S L A G C P T T K C A S I V S P C
8
T P L T V T I P I S L A G C P T T K C A S I V S P C K G
35
63.9%
NZ_WIXN01000006.1 and 1 other:
NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide
Lanthipeptides: GHD25_RS06900_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C
34
D A T P T P T T I I P+S L A C P T T C S S P C
1
E D A T P D T-H P T T I-I P V S L A V C P T T T C R S F S S P C
32
63.2%
NZ_AUCI01000015.1 and 1 other:
NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide
Lanthipeptides: G475_RS0114655_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S D P + T T+T I P I S G C P T T K C A S+V P C N D
3
S D Q Q P A S H P T T T V T I P I S A W G C P T T K C A S V V E P C N D
38
63.2%
NZ_FOXD01000022.1 and 1 other:
NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide
Lanthipeptides: BM124_RS15255_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S D P + T T+T I P I S G C P T T K C A S+V P C N D
3
S D Q Q P A S H P T T T V T I P I S A W G C P T T K C A S V V K P C N D
38
61.1%
NZ_CP063142.1 and 5 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide
Lanthipeptides: HPB58_RS21455_lanthipeptide
12
T I T I P I S L A G C P T T K C A S I V S P C N D
36
T+T I P I S L A C P T T+C A S I V S P C N D
8
T V T I P I S L A A C P T T Q C A S I V S P C N D
32
61.1%
NZ_LT745762.1 and 1 other:
NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide
Lanthipeptides: B2C77_RS21505_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T I I P+S L A C P T T K C A S+V P C N D
7
T P A T I-I P V S L A I C P T T K C A S V V K P C N D
33
58.3%
NZ_BOSN01000007.1 and 3 others:
NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide
Lanthipeptides: KJS43_RS18000_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T I I P+S L A C P T T K C A S+V P C N
7
T P A T I-I P V S L A I C P T T K C A S V V K P C N G
33
58.3%
NZ_BQME02000001.1 and 3 others:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide
Lanthipeptides: MFF31_RS04090_lanthipeptide
12
T I T I P I S L A G C P T T K C A S I V S P C N
35
T I I P I S L A C P T T+C A S I V S P C N
6
T I I I P I S L A A C P T T R C A S I V S P C N
29
55.6%
NZ_BQME02000001.1 and 1 other:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04085_lanthipeptide
Lanthipeptides: MFF31_RS04085_lanthipeptide
12
T I T I P I S L A G C P T T K C A S I V S P C N
35
T I I P I S L A C P T T+C A S I V S C N
6
T I I I P I S L A A C P T T R C A S I V S S C N
29
55.6%
NZ_KQ040792.1 and 1 other:
NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide
Lanthipeptides: WH45_RS23705_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T I I P+S L A C P T T+C A S I V C N
8
T P A T I-I P V S L A I C P T T R C A S I V E S C N G
34

#### MIBiG 4.0 matches for LQ568_RS00590

24.3%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
13
I T I P I S L A G C P T T K C A S
29
+ + +S A C P T T K C S
19
V A V G V S A A F C P T T K C T S
35
19.4%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
22
C P T T K C A S
29
C P T T K C S
17
C P T T K C T S
24
LQ568_RS00595
Leader:
MKKEFLALELMTEEELKELAGG
Core:
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
Core with dehydrations:
Dha E A Dhb P M Dhb V Dhb P Dhb Dhb I Dhb I P I Dha L A G Cys P Dhb Dhb K Cys A Dha I V Dha P Cys N D

#### antiSMASH-DB 4.0 matches for LQ568_RS00595

100.0%
NC_023073.1 and 71 others:
NC_023073.1 Lanthipeptides: U722_RS19990_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide
Lanthipeptides: U722_RS19990_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
97.2%
NC_023073.1 and 71 others:
NC_023073.1 Lanthipeptides: U722_RS19995_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide
Lanthipeptides: U722_RS19995_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S+A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
97.2%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10240_lanthipeptide
Lanthipeptides: J7E20_RS10240_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S E A T P M T+T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S E A T P M T I T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
with 60 more sequence matches
Only the first 10 are displayed here.
91.7%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10245_lanthipeptide
Lanthipeptides: J7E20_RS10245_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S+A P M T+T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S D A A P M T I T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
66.7%
NZ_JAMDLZ010000027.1:
Lanthipeptides: M5W82_RS15520_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T+T I P I S L A G C P T T K C A S I V S P C
8
T P L T V T I P I S L A G C P T T K C A S I V S P C K G
35
63.9%
NZ_KQ040792.1 and 1 other:
NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide
Lanthipeptides: WH45_RS23705_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N
35
+E+T P T P T I I P+S L A C P T T+C A S I V C N
1
A E S T P-N G T P A T I-I P V S L A I C P T T R C A S I V E S C N
33
61.1%
NZ_CP063142.1 and 5 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide
Lanthipeptides: HPB58_RS21455_lanthipeptide
12
T I T I P I S L A G C P T T K C A S I V S P C N D
36
T+T I P I S L A C P T T+C A S I V S P C N D
8
T V T I P I S L A A C P T T Q C A S I V S P C N D
32
61.1%
NZ_LT745762.1 and 1 other:
NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide
Lanthipeptides: B2C77_RS21505_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T I I P+S L A C P T T K C A S+V P C N D
7
T P A T I-I P V S L A I C P T T K C A S V V K P C N D
33
61.1%
NZ_WIXN01000006.1 and 1 other:
NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide
Lanthipeptides: GHD25_RS06900_lanthipeptide
2
E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C
34
+A T P T P T T I I P+S L A C P T T C S S P C
2
D A T P D T-H P T T I-I P V S L A V C P T T T C R S F S S P C
32
60.5%
NZ_AUCI01000015.1 and 1 other:
NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide
Lanthipeptides: G475_RS0114655_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S+ P + T T+T I P I S G C P T T K C A S+V P C N D
3
S D Q Q P A S H P T T T V T I P I S A W G C P T T K C A S V V E P C N D
38
60.5%
NZ_FOXD01000022.1 and 1 other:
NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide
Lanthipeptides: BM124_RS15255_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S+ P + T T+T I P I S G C P T T K C A S+V P C N D
3
S D Q Q P A S H P T T T V T I P I S A W G C P T T K C A S V V K P C N D
38
58.3%
NZ_BOSN01000007.1 and 3 others:
NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide
Lanthipeptides: KJS43_RS18000_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T I I P+S L A C P T T K C A S+V P C N
7
T P A T I-I P V S L A I C P T T K C A S V V K P C N G
33
58.3%
NZ_BQME02000001.1 and 3 others:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide
Lanthipeptides: MFF31_RS04090_lanthipeptide
12
T I T I P I S L A G C P T T K C A S I V S P C N
35
T I I P I S L A C P T T+C A S I V S P C N
6
T I I I P I S L A A C P T T R C A S I V S P C N
29

#### MIBiG 4.0 matches for LQ568_RS00595

24.3%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
13
I T I P I S L A G C P T T K C A S
29
+ + +S A C P T T K C S
19
V A V G V S A A F C P T T K C T S
35
19.4%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
22
C P T T K C A S
29
C P T T K C S
17
C P T T K C T S
24
LQ568_RS00610
Leader:
MNEKMYRFAGDLREELEEISLS
Core:
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
Core with dehydrations:
E F Dha G G G G A E Q R G I Dha Q G N D G K L Cys Dhb L Dhb W E Cys G L Cys P Dhb H Dhb Cys W Cys

#### antiSMASH-DB 4.0 matches for LQ568_RS00610

100.0%
NC_023073.1 and 65 others:
NC_023073.1 Lanthipeptides: U722_RS06170_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptide
Lanthipeptides: U722_RS06170_lanthipeptide
1
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
1
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
97.4%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10220_lanthipeptide
Lanthipeptides: J7E20_RS10220_lanthipeptide
1
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C+C
1
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C F C
38
86.8%
NZ_CP016371.1 and 7 others:
NZ_CP016371.1 Lanthipeptides: A5891_RS06120_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptide
Lanthipeptides: A5891_RS06120_lanthipeptide
6
G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
1
G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
33
with 92 more sequence matches
Only the first 10 are displayed here.
71.1%
NZ_BQME02000001.1 and 1 other:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04105_lanthipeptide
Lanthipeptides: MFF31_RS04105_lanthipeptide
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C-W C
38
A E Q R G I S Q G N D G K C T L T W E C +C P T T C W C
1
A E Q R G I S Q G N D G K Y C T L T W E C S V C P T L T C F W C
32
68.4%
NZ_CP063142.1 and 10 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21475_lanthipeptide NZ_FOXX01000007.1 Lanthipeptides: BM012_RS26100_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptide NZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptide NZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptide
Lanthipeptides: HPB58_RS21475_lanthipeptide
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E Q R G I S Q G N D G C T+T W E C +C P T H T C W C
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
68.4%
NZ_FOXD01000022.1 and 1 other:
NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15270_lanthipeptide
Lanthipeptides: BM124_RS15270_lanthipeptide
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E R G I S Q G N D G C T+T W E C G+C P T H T C W C
3
A E P R G I S Q G N D G D Y C T I T W E C G M C P T H T C W C
33
68.4%
NZ_KQ040792.1 and 1 other:
NZ_KQ040792.1 Lanthipeptides: WH45_RS23330_lanthipeptide
Lanthipeptides: WH45_RS23330_lanthipeptide
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E +G+S Q G N D G K+C T L T W E C G L C P T H T C+C
1
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F C
31
65.8%
NZ_BOSN01000007.1 and 3 others:
NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18005_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptide
Lanthipeptides: KJS43_RS18005_lanthipeptide
7
G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E G I S Q G N D G K C T+T W E C +C P T H T C W C
1
A A E P M G I S Q G N D G K Y C T I T W E C S I C P T H T C W C
32
65.8%
NZ_LT745762.1 and 1 other:
NZ_LT745762.1 Lanthipeptides: B2C77_RS00795_lanthipeptide
Lanthipeptides: B2C77_RS00795_lanthipeptide
7
G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E G I S Q G N D G K C T+T W E C +C P T H T C W C
1
A A E P M G I S Q G N D G K W C T V T W E C S I C P T H T C W C
32
63.2%
NZ_AUCI01000015.1 and 1 other:
NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114640_lanthipeptide
Lanthipeptides: G475_RS0114640_lanthipeptide
6
G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
E R G+S Q G N D G C T+T W E C G+C P T H T C W C
1
A D V E T R G L S Q G N D G D Y C T I T W E C G M C P T H T C W C
33
63.2%
NZ_CP101913.1 and 1 other:
NZ_CP101913.1 Lanthipeptides: NP440_RS09135_lanthipeptide
Lanthipeptides: NP440_RS09135_lanthipeptide
7
G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E G I S+ N D G K C T L T W E C +C P T H T C W C
1
A A E P M G I S E D N D G K Y C T L T W E C S I C P T H T C W C
32
63.2%
NZ_KV917378.1 and 1 other:
NZ_KV917378.1 Lanthipeptides: BK581_RS07320_lanthipeptide
Lanthipeptides: BK581_RS07320_lanthipeptide
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A+ +G I S Q G N D G K C T+T W E C +C P T H T C W C
1
A D V Q G I S Q G N D G K Y C T I T W E C S I C P T H T C W C
31
55.3%
NZ_CP040417.1 and 7 others:
NZ_CP040417.1 Lanthipeptides: FE328_RS09040_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide
Lanthipeptides: FE328_RS09040_lanthipeptide
5
G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W
37
G G R +S+G N G K+C T L T W E C G+C P+H T C+
1
G V G K W I R K L S K G N T G K V C T L T W E C G I C P S H T C F
33

#### MIBiG 4.0 matches for LQ568_RS00610

23.7%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
16
G N D G K L C T L T W E C
28
G N G C T L T E C
11
G N K G A Y C T L T V E C
23
23.7%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
16
G N D G K L C T L T W E C
28
G N+G C T L T E C
13
G N N G G W C T L T K E C
25
15.8%
BGC0000580.3 (EGD17355.1):
Lasso peptide: xanthomonin II or xanthomonin I
6
G G A E Q R G I S Q
15
G G G I S Q
10
G G I T T L G I S Q
19
with 1 more sequence matches
12.8%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
22
C T L T W E C
28
C T L+ E C
28
C T L S K E C
34
allorf_101096_101173
Leader:
MRIHSIFIRMQGLYA
Core:
Q V I C P T N A T Y
Core with dehydrations:
Q V I Cys P Dhb N A Dhb Y

#### antiSMASH-DB 4.0 matches for allorf_101096_101173

100.0%
NZ_CP016371.1 and 22 others:
NZ_CP017775.1 Lanthipeptides: allorf_1370160_1370237_lanthipeptide NZ_CP018295.1 Lanthipeptides: allorf_1230930_1231007_lanthipeptide NZ_CP023075.1 Lanthipeptides: allorf_1287116_1287193_lanthipeptide NZ_CP027429.1 Lanthipeptides: allorf_2639262_2639339_lanthipeptide NZ_CP027429.1 Lanthipeptides: allorf_2639262_2639339_lanthipeptide NZ_CP033967.1 Lanthipeptides: allorf_3538116_3538193_lanthipeptide NZ_CP033967.1 Lanthipeptides: allorf_3538116_3538193_lanthipeptide NZ_CP044133.1 Lanthipeptides: allorf_1292127_1292204_lanthipeptide NZ_CP044444.1 Lanthipeptides: allorf_2627237_2627314_lanthipeptide NZ_CP048002.1 Lanthipeptides: allorf_3123788_3123865_lanthipeptide NZ_CP059405.1 Lanthipeptides: allorf_3176215_3176292_lanthipeptide NZ_CP059495.1 Lanthipeptides: allorf_1278377_1278454_lanthipeptide NZ_CP064091.1 Lanthipeptides: allorf_3836090_3836167_lanthipeptide NZ_CP083716.1 Lanthipeptides: allorf_110856_110933_lanthipeptide NZ_CP092110.1 Lanthipeptides: allorf_0704361_0704438_lanthipeptide NZ_CP092110.1 Lanthipeptides: allorf_0704361_0704438_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: allorf_101096_101173_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: allorf_101096_101173_lanthipeptide NZ_KB206086.1 Lanthipeptides: allorf_0474373_0474450_lanthipeptide NZ_KN050798.1 Lanthipeptides: allorf_0351480_0351557_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: allorf_337625_337702_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: allorf_337625_337702_lanthipeptide
Lanthipeptides: allorf_1210473_1210550_lanthipeptide
1
Q V I C P T N A T Y
10
Q V I C P T N A T Y
1
Q V I C P T N A T Y
10
allorf_107486_107668
Leader:
MKGGEIWNMKKNFSALYETSEQELKELVGG
Core:
Q N S V S I T T Y P I T N H I C P T I T V G C A C P Q R Q V
Core with dehydrations:
Q N Dha V Dha I Dhb Dhb Y P I Dhb N H I Cys P Dhb I Dhb V G Cys A Cys P Q R Q V

#### antiSMASH-DB 4.0 matches for allorf_107486_107668

100.0%
NZ_CP016371.1 and 25 others:
NZ_CP017775.1 Lanthipeptides: allorf_1362373_1362555_lanthipeptide NZ_CP018295.1 Lanthipeptides: allorf_1224462_1224620_lanthipeptide NZ_CP023075.1 Lanthipeptides: allorf_1280618_1280800_lanthipeptide NZ_CP027429.1 Lanthipeptides: allorf_2645650_2645832_lanthipeptide NZ_CP027429.1 Lanthipeptides: allorf_2645650_2645832_lanthipeptide NZ_CP033967.1 Lanthipeptides: allorf_3544503_3544661_lanthipeptide NZ_CP033967.1 Lanthipeptides: allorf_3544503_3544661_lanthipeptide NZ_CP035393.1 Lanthipeptides: allorf_1361512_1361694_lanthipeptide NZ_CP044133.1 Lanthipeptides: allorf_1285659_1285817_lanthipeptide NZ_CP044444.1 Lanthipeptides: allorf_2620740_2620922_lanthipeptide NZ_CP048002.1 Lanthipeptides: allorf_3117293_3117475_lanthipeptide NZ_CP059405.1 Lanthipeptides: allorf_3169717_3169899_lanthipeptide NZ_CP059495.1 Lanthipeptides: allorf_1271882_1272064_lanthipeptide NZ_CP064091.1 Lanthipeptides: allorf_3829595_3829777_lanthipeptide NZ_CP083716.1 Lanthipeptides: allorf_104358_104540_lanthipeptide NZ_CP092110.1 Lanthipeptides: allorf_0710754_0710936_lanthipeptide NZ_CP092110.1 Lanthipeptides: allorf_0710754_0710936_lanthipeptide NZ_CP116013.1 Lanthipeptides: allorf_0410910_0411092_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: allorf_107486_107668_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: allorf_107486_107668_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: allorf_050414_050596_lanthipeptide NZ_KB206086.1 Lanthipeptides: allorf_0467875_0468057_lanthipeptide NZ_KN050798.1 Lanthipeptides: allorf_0345012_0345170_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: allorf_344018_344200_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: allorf_344018_344200_lanthipeptide
Lanthipeptides: allorf_1203980_1204162_lanthipeptide
1
Q N S V S I T T Y P I T N H I C P T I T V G C A C P Q R Q V
30
Q N S V S I T T Y P I T N H I C P T I T V G C A C P Q R Q V
1
Q N S V S I T T Y P I T N H I C P T I T V G C A C P Q R Q V
30
93.3%
NC_023073.1 and 18 others:
NZ_CP010556.1 Lanthipeptides: allorf_1170865_1171047_lanthipeptide NZ_CP016395.1 Lanthipeptides: allorf_1266893_1267075_lanthipeptide NZ_CP023133.1 Lanthipeptides: allorf_0800979_0801161_lanthipeptide NZ_CP025341.1 Lanthipeptides: allorf_1207246_1207428_lanthipeptide NZ_CP028440.1 Lanthipeptides: allorf_1169247_1169429_lanthipeptide NZ_CP028440.1 Lanthipeptides: allorf_1169247_1169429_lanthipeptide NZ_CP031694.1 Lanthipeptides: allorf_3757607_3757789_lanthipeptide NZ_CP031694.1 Lanthipeptides: allorf_3757607_3757789_lanthipeptide NZ_CP065790.1 Lanthipeptides: allorf_1228836_1229018_lanthipeptide NZ_CP072310.1 Lanthipeptides: allorf_3340146_3340328_lanthipeptide NZ_CP074685.1 Lanthipeptides: allorf_1220760_1220942_lanthipeptide NZ_CP075054.1 Lanthipeptides: allorf_2702843_2703025_lanthipeptide NZ_CP075054.1 Lanthipeptides: allorf_2702843_2703025_lanthipeptide NZ_CP088300.1 Lanthipeptides: allorf_1174611_1174793_lanthipeptide NZ_CP090905.1 Lanthipeptides: allorf_1201177_1201359_lanthipeptide NZ_CP094618.1 Lanthipeptides: allorf_1135121_1135303_lanthipeptide NZ_CP119675.1 Lanthipeptides: allorf_2182837_2183019_lanthipeptide NZ_LN999829.1 Lanthipeptides: allorf_1186077_1186259_lanthipeptide
Lanthipeptides: allorf_1238739_1238921_lanthipeptide
1
Q N S V S I T T Y P I T N H I C P T I T V G C A C P Q R Q V
30
Q N S V S I T T P I T N H+C P T I T V G C A C P Q R Q V
1
Q N S V S I T T I P I T N H V C P T I T V G C A C P Q R Q V
30
66.7%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10235_lanthipeptide
Lanthipeptides: J7E20_RS10235_lanthipeptide
1
Q N S V S I T T Y P I T N H I C P T I T V G C A C P Q R Q V
30
Q N +S I T T P T H+C T+T V G C A C P Q+Q+
1
Q N L I S I T T I P F T-H L C A T V T V G C A C P Q K Q I
29
with 3 more sequence matches
23.5%
NZ_CP048048.1 and 2 others:
NZ_CP048050.1 Lanthipeptides: GW570_RS15170_lanthipeptide NZ_CP088267.1 Lanthipeptides: LRE50_RS16510_lanthipeptide
Lanthipeptides: GW571_RS15175_lanthipeptide
8
T Y P I T N H I C P T I T V G C A C P Q R Q
29
T+ +T +C T I A C Q
8
T F K L T V K V C R T I I T T T A C G S T Q
29
20.0%
NZ_JANIOB010000033.1:
Lanthipeptides: NQ113_RS28010_lanthipeptide
11
I T N H I C P T I
19
T N +C P T I
15
F T N R L C P T I
23
15.8%
NZ_KB907258.1:
Lanthipeptides: G358_RS0114910_lanthipeptide
2
N S V S I T T Y P I T N H I C P T I T
20
N S+ I+ Y + C P++
6
N S I R I S I Y K C L S L F C P S V A
24

#### MIBiG 4.0 matches for allorf_107486_107668

13.3%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
18
T I T V G C
23
T+T V C
18
T L T V E C
23

#### Lanthipeptide(s) for LQ568_RS00605

LQ568_RS00590
Leader:
MKKDFQALTPMTEEELKNLAGG
Core:
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
Core with dehydrations:
Dha D A Dhb P M Dhb V Dhb P Dhb Dhb I Dhb I P I Dha L A G Cys P Dhb Dhb K Cys A Dha I V Dha P Cys N D

#### antiSMASH-DB 4.0 matches for LQ568_RS00590

100.0%
NC_023073.1 and 71 others:
NC_023073.1 Lanthipeptides: U722_RS19995_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide
Lanthipeptides: U722_RS19995_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
97.2%
NC_023073.1 and 71 others:
NC_023073.1 Lanthipeptides: U722_RS19990_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide
Lanthipeptides: U722_RS19990_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S+A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
94.4%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10245_lanthipeptide
Lanthipeptides: J7E20_RS10245_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S D A P M T+T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S D A A P M T I T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
with 60 more sequence matches
Only the first 10 are displayed here.
66.7%
NZ_JAMDLZ010000027.1:
Lanthipeptides: M5W82_RS15520_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T+T I P I S L A G C P T T K C A S I V S P C
8
T P L T V T I P I S L A G C P T T K C A S I V S P C K G
35
63.9%
NZ_WIXN01000006.1 and 1 other:
NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide
Lanthipeptides: GHD25_RS06900_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C
34
D A T P T P T T I I P+S L A C P T T C S S P C
1
E D A T P D T-H P T T I-I P V S L A V C P T T T C R S F S S P C
32
63.2%
NZ_AUCI01000015.1 and 1 other:
NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide
Lanthipeptides: G475_RS0114655_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S D P + T T+T I P I S G C P T T K C A S+V P C N D
3
S D Q Q P A S H P T T T V T I P I S A W G C P T T K C A S V V E P C N D
38
63.2%
NZ_FOXD01000022.1 and 1 other:
NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide
Lanthipeptides: BM124_RS15255_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S D P + T T+T I P I S G C P T T K C A S+V P C N D
3
S D Q Q P A S H P T T T V T I P I S A W G C P T T K C A S V V K P C N D
38
61.1%
NZ_CP063142.1 and 5 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide
Lanthipeptides: HPB58_RS21455_lanthipeptide
12
T I T I P I S L A G C P T T K C A S I V S P C N D
36
T+T I P I S L A C P T T+C A S I V S P C N D
8
T V T I P I S L A A C P T T Q C A S I V S P C N D
32
61.1%
NZ_LT745762.1 and 1 other:
NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide
Lanthipeptides: B2C77_RS21505_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T I I P+S L A C P T T K C A S+V P C N D
7
T P A T I-I P V S L A I C P T T K C A S V V K P C N D
33
58.3%
NZ_BOSN01000007.1 and 3 others:
NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide
Lanthipeptides: KJS43_RS18000_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T I I P+S L A C P T T K C A S+V P C N
7
T P A T I-I P V S L A I C P T T K C A S V V K P C N G
33
58.3%
NZ_BQME02000001.1 and 3 others:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide
Lanthipeptides: MFF31_RS04090_lanthipeptide
12
T I T I P I S L A G C P T T K C A S I V S P C N
35
T I I P I S L A C P T T+C A S I V S P C N
6
T I I I P I S L A A C P T T R C A S I V S P C N
29
55.6%
NZ_BQME02000001.1 and 1 other:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04085_lanthipeptide
Lanthipeptides: MFF31_RS04085_lanthipeptide
12
T I T I P I S L A G C P T T K C A S I V S P C N
35
T I I P I S L A C P T T+C A S I V S C N
6
T I I I P I S L A A C P T T R C A S I V S S C N
29
55.6%
NZ_KQ040792.1 and 1 other:
NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide
Lanthipeptides: WH45_RS23705_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T I I P+S L A C P T T+C A S I V C N
8
T P A T I-I P V S L A I C P T T R C A S I V E S C N G
34

#### MIBiG 4.0 matches for LQ568_RS00590

24.3%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
13
I T I P I S L A G C P T T K C A S
29
+ + +S A C P T T K C S
19
V A V G V S A A F C P T T K C T S
35
19.4%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
22
C P T T K C A S
29
C P T T K C S
17
C P T T K C T S
24
LQ568_RS00595
Leader:
MKKEFLALELMTEEELKELAGG
Core:
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
Core with dehydrations:
Dha E A Dhb P M Dhb V Dhb P Dhb Dhb I Dhb I P I Dha L A G Cys P Dhb Dhb K Cys A Dha I V Dha P Cys N D

#### antiSMASH-DB 4.0 matches for LQ568_RS00595

100.0%
NC_023073.1 and 71 others:
NC_023073.1 Lanthipeptides: U722_RS19990_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide
Lanthipeptides: U722_RS19990_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
97.2%
NC_023073.1 and 71 others:
NC_023073.1 Lanthipeptides: U722_RS19995_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide
Lanthipeptides: U722_RS19995_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S+A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
97.2%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10240_lanthipeptide
Lanthipeptides: J7E20_RS10240_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S E A T P M T+T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S E A T P M T I T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
with 60 more sequence matches
Only the first 10 are displayed here.
91.7%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10245_lanthipeptide
Lanthipeptides: J7E20_RS10245_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S+A P M T+T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S D A A P M T I T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
66.7%
NZ_JAMDLZ010000027.1:
Lanthipeptides: M5W82_RS15520_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T+T I P I S L A G C P T T K C A S I V S P C
8
T P L T V T I P I S L A G C P T T K C A S I V S P C K G
35
63.9%
NZ_KQ040792.1 and 1 other:
NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide
Lanthipeptides: WH45_RS23705_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N
35
+E+T P T P T I I P+S L A C P T T+C A S I V C N
1
A E S T P-N G T P A T I-I P V S L A I C P T T R C A S I V E S C N
33
61.1%
NZ_CP063142.1 and 5 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide
Lanthipeptides: HPB58_RS21455_lanthipeptide
12
T I T I P I S L A G C P T T K C A S I V S P C N D
36
T+T I P I S L A C P T T+C A S I V S P C N D
8
T V T I P I S L A A C P T T Q C A S I V S P C N D
32
61.1%
NZ_LT745762.1 and 1 other:
NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide
Lanthipeptides: B2C77_RS21505_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T I I P+S L A C P T T K C A S+V P C N D
7
T P A T I-I P V S L A I C P T T K C A S V V K P C N D
33
61.1%
NZ_WIXN01000006.1 and 1 other:
NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide
Lanthipeptides: GHD25_RS06900_lanthipeptide
2
E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C
34
+A T P T P T T I I P+S L A C P T T C S S P C
2
D A T P D T-H P T T I-I P V S L A V C P T T T C R S F S S P C
32
60.5%
NZ_AUCI01000015.1 and 1 other:
NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide
Lanthipeptides: G475_RS0114655_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S+ P + T T+T I P I S G C P T T K C A S+V P C N D
3
S D Q Q P A S H P T T T V T I P I S A W G C P T T K C A S V V E P C N D
38
60.5%
NZ_FOXD01000022.1 and 1 other:
NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide
Lanthipeptides: BM124_RS15255_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S+ P + T T+T I P I S G C P T T K C A S+V P C N D
3
S D Q Q P A S H P T T T V T I P I S A W G C P T T K C A S V V K P C N D
38
58.3%
NZ_BOSN01000007.1 and 3 others:
NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide
Lanthipeptides: KJS43_RS18000_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T I I P+S L A C P T T K C A S+V P C N
7
T P A T I-I P V S L A I C P T T K C A S V V K P C N G
33
58.3%
NZ_BQME02000001.1 and 3 others:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide
Lanthipeptides: MFF31_RS04090_lanthipeptide
12
T I T I P I S L A G C P T T K C A S I V S P C N
35
T I I P I S L A C P T T+C A S I V S P C N
6
T I I I P I S L A A C P T T R C A S I V S P C N
29

#### MIBiG 4.0 matches for LQ568_RS00595

24.3%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
13
I T I P I S L A G C P T T K C A S
29
+ + +S A C P T T K C S
19
V A V G V S A A F C P T T K C T S
35
19.4%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
22
C P T T K C A S
29
C P T T K C S
17
C P T T K C T S
24
LQ568_RS00610
Leader:
MNEKMYRFAGDLREELEEISLS
Core:
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
Core with dehydrations:
E F Dha G G G G A E Q R G I Dha Q G N D G K L Cys Dhb L Dhb W E Cys G L Cys P Dhb H Dhb Cys W Cys

#### antiSMASH-DB 4.0 matches for LQ568_RS00610

100.0%
NC_023073.1 and 65 others:
NC_023073.1 Lanthipeptides: U722_RS06170_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptide
Lanthipeptides: U722_RS06170_lanthipeptide
1
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
1
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
97.4%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10220_lanthipeptide
Lanthipeptides: J7E20_RS10220_lanthipeptide
1
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C+C
1
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C F C
38
86.8%
NZ_CP016371.1 and 7 others:
NZ_CP016371.1 Lanthipeptides: A5891_RS06120_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptide
Lanthipeptides: A5891_RS06120_lanthipeptide
6
G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
1
G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
33
with 92 more sequence matches
Only the first 10 are displayed here.
71.1%
NZ_BQME02000001.1 and 1 other:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04105_lanthipeptide
Lanthipeptides: MFF31_RS04105_lanthipeptide
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C-W C
38
A E Q R G I S Q G N D G K C T L T W E C +C P T T C W C
1
A E Q R G I S Q G N D G K Y C T L T W E C S V C P T L T C F W C
32
68.4%
NZ_CP063142.1 and 10 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21475_lanthipeptide NZ_FOXX01000007.1 Lanthipeptides: BM012_RS26100_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptide NZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptide NZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptide
Lanthipeptides: HPB58_RS21475_lanthipeptide
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E Q R G I S Q G N D G C T+T W E C +C P T H T C W C
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
68.4%
NZ_FOXD01000022.1 and 1 other:
NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15270_lanthipeptide
Lanthipeptides: BM124_RS15270_lanthipeptide
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E R G I S Q G N D G C T+T W E C G+C P T H T C W C
3
A E P R G I S Q G N D G D Y C T I T W E C G M C P T H T C W C
33
68.4%
NZ_KQ040792.1 and 1 other:
NZ_KQ040792.1 Lanthipeptides: WH45_RS23330_lanthipeptide
Lanthipeptides: WH45_RS23330_lanthipeptide
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E +G+S Q G N D G K+C T L T W E C G L C P T H T C+C
1
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F C
31
65.8%
NZ_BOSN01000007.1 and 3 others:
NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18005_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptide
Lanthipeptides: KJS43_RS18005_lanthipeptide
7
G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E G I S Q G N D G K C T+T W E C +C P T H T C W C
1
A A E P M G I S Q G N D G K Y C T I T W E C S I C P T H T C W C
32
65.8%
NZ_LT745762.1 and 1 other:
NZ_LT745762.1 Lanthipeptides: B2C77_RS00795_lanthipeptide
Lanthipeptides: B2C77_RS00795_lanthipeptide
7
G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E G I S Q G N D G K C T+T W E C +C P T H T C W C
1
A A E P M G I S Q G N D G K W C T V T W E C S I C P T H T C W C
32
63.2%
NZ_AUCI01000015.1 and 1 other:
NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114640_lanthipeptide
Lanthipeptides: G475_RS0114640_lanthipeptide
6
G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
E R G+S Q G N D G C T+T W E C G+C P T H T C W C
1
A D V E T R G L S Q G N D G D Y C T I T W E C G M C P T H T C W C
33
63.2%
NZ_CP101913.1 and 1 other:
NZ_CP101913.1 Lanthipeptides: NP440_RS09135_lanthipeptide
Lanthipeptides: NP440_RS09135_lanthipeptide
7
G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E G I S+ N D G K C T L T W E C +C P T H T C W C
1
A A E P M G I S E D N D G K Y C T L T W E C S I C P T H T C W C
32
63.2%
NZ_KV917378.1 and 1 other:
NZ_KV917378.1 Lanthipeptides: BK581_RS07320_lanthipeptide
Lanthipeptides: BK581_RS07320_lanthipeptide
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A+ +G I S Q G N D G K C T+T W E C +C P T H T C W C
1
A D V Q G I S Q G N D G K Y C T I T W E C S I C P T H T C W C
31
55.3%
NZ_CP040417.1 and 7 others:
NZ_CP040417.1 Lanthipeptides: FE328_RS09040_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide
Lanthipeptides: FE328_RS09040_lanthipeptide
5
G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W
37
G G R +S+G N G K+C T L T W E C G+C P+H T C+
1
G V G K W I R K L S K G N T G K V C T L T W E C G I C P S H T C F
33

#### MIBiG 4.0 matches for LQ568_RS00610

23.7%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
16
G N D G K L C T L T W E C
28
G N G C T L T E C
11
G N K G A Y C T L T V E C
23
23.7%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
16
G N D G K L C T L T W E C
28
G N+G C T L T E C
13
G N N G G W C T L T K E C
25
15.8%
BGC0000580.3 (EGD17355.1):
Lasso peptide: xanthomonin II or xanthomonin I
6
G G A E Q R G I S Q
15
G G G I S Q
10
G G I T T L G I S Q
19
with 1 more sequence matches
12.8%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
22
C T L T W E C
28
C T L+ E C
28
C T L S K E C
34
allorf_101096_101173
Leader:
MRIHSIFIRMQGLYA
Core:
Q V I C P T N A T Y
Core with dehydrations:
Q V I Cys P Dhb N A Dhb Y

#### antiSMASH-DB 4.0 matches for allorf_101096_101173

100.0%
NZ_CP016371.1 and 22 others:
NZ_CP017775.1 Lanthipeptides: allorf_1370160_1370237_lanthipeptide NZ_CP018295.1 Lanthipeptides: allorf_1230930_1231007_lanthipeptide NZ_CP023075.1 Lanthipeptides: allorf_1287116_1287193_lanthipeptide NZ_CP027429.1 Lanthipeptides: allorf_2639262_2639339_lanthipeptide NZ_CP027429.1 Lanthipeptides: allorf_2639262_2639339_lanthipeptide NZ_CP033967.1 Lanthipeptides: allorf_3538116_3538193_lanthipeptide NZ_CP033967.1 Lanthipeptides: allorf_3538116_3538193_lanthipeptide NZ_CP044133.1 Lanthipeptides: allorf_1292127_1292204_lanthipeptide NZ_CP044444.1 Lanthipeptides: allorf_2627237_2627314_lanthipeptide NZ_CP048002.1 Lanthipeptides: allorf_3123788_3123865_lanthipeptide NZ_CP059405.1 Lanthipeptides: allorf_3176215_3176292_lanthipeptide NZ_CP059495.1 Lanthipeptides: allorf_1278377_1278454_lanthipeptide NZ_CP064091.1 Lanthipeptides: allorf_3836090_3836167_lanthipeptide NZ_CP083716.1 Lanthipeptides: allorf_110856_110933_lanthipeptide NZ_CP092110.1 Lanthipeptides: allorf_0704361_0704438_lanthipeptide NZ_CP092110.1 Lanthipeptides: allorf_0704361_0704438_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: allorf_101096_101173_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: allorf_101096_101173_lanthipeptide NZ_KB206086.1 Lanthipeptides: allorf_0474373_0474450_lanthipeptide NZ_KN050798.1 Lanthipeptides: allorf_0351480_0351557_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: allorf_337625_337702_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: allorf_337625_337702_lanthipeptide
Lanthipeptides: allorf_1210473_1210550_lanthipeptide
1
Q V I C P T N A T Y
10
Q V I C P T N A T Y
1
Q V I C P T N A T Y
10
allorf_107486_107668
Leader:
MKGGEIWNMKKNFSALYETSEQELKELVGG
Core:
Q N S V S I T T Y P I T N H I C P T I T V G C A C P Q R Q V
Core with dehydrations:
Q N Dha V Dha I Dhb Dhb Y P I Dhb N H I Cys P Dhb I Dhb V G Cys A Cys P Q R Q V

#### antiSMASH-DB 4.0 matches for allorf_107486_107668

100.0%
NZ_CP016371.1 and 25 others:
NZ_CP017775.1 Lanthipeptides: allorf_1362373_1362555_lanthipeptide NZ_CP018295.1 Lanthipeptides: allorf_1224462_1224620_lanthipeptide NZ_CP023075.1 Lanthipeptides: allorf_1280618_1280800_lanthipeptide NZ_CP027429.1 Lanthipeptides: allorf_2645650_2645832_lanthipeptide NZ_CP027429.1 Lanthipeptides: allorf_2645650_2645832_lanthipeptide NZ_CP033967.1 Lanthipeptides: allorf_3544503_3544661_lanthipeptide NZ_CP033967.1 Lanthipeptides: allorf_3544503_3544661_lanthipeptide NZ_CP035393.1 Lanthipeptides: allorf_1361512_1361694_lanthipeptide NZ_CP044133.1 Lanthipeptides: allorf_1285659_1285817_lanthipeptide NZ_CP044444.1 Lanthipeptides: allorf_2620740_2620922_lanthipeptide NZ_CP048002.1 Lanthipeptides: allorf_3117293_3117475_lanthipeptide NZ_CP059405.1 Lanthipeptides: allorf_3169717_3169899_lanthipeptide NZ_CP059495.1 Lanthipeptides: allorf_1271882_1272064_lanthipeptide NZ_CP064091.1 Lanthipeptides: allorf_3829595_3829777_lanthipeptide NZ_CP083716.1 Lanthipeptides: allorf_104358_104540_lanthipeptide NZ_CP092110.1 Lanthipeptides: allorf_0710754_0710936_lanthipeptide NZ_CP092110.1 Lanthipeptides: allorf_0710754_0710936_lanthipeptide NZ_CP116013.1 Lanthipeptides: allorf_0410910_0411092_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: allorf_107486_107668_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: allorf_107486_107668_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: allorf_050414_050596_lanthipeptide NZ_KB206086.1 Lanthipeptides: allorf_0467875_0468057_lanthipeptide NZ_KN050798.1 Lanthipeptides: allorf_0345012_0345170_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: allorf_344018_344200_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: allorf_344018_344200_lanthipeptide
Lanthipeptides: allorf_1203980_1204162_lanthipeptide
1
Q N S V S I T T Y P I T N H I C P T I T V G C A C P Q R Q V
30
Q N S V S I T T Y P I T N H I C P T I T V G C A C P Q R Q V
1
Q N S V S I T T Y P I T N H I C P T I T V G C A C P Q R Q V
30
93.3%
NC_023073.1 and 18 others:
NZ_CP010556.1 Lanthipeptides: allorf_1170865_1171047_lanthipeptide NZ_CP016395.1 Lanthipeptides: allorf_1266893_1267075_lanthipeptide NZ_CP023133.1 Lanthipeptides: allorf_0800979_0801161_lanthipeptide NZ_CP025341.1 Lanthipeptides: allorf_1207246_1207428_lanthipeptide NZ_CP028440.1 Lanthipeptides: allorf_1169247_1169429_lanthipeptide NZ_CP028440.1 Lanthipeptides: allorf_1169247_1169429_lanthipeptide NZ_CP031694.1 Lanthipeptides: allorf_3757607_3757789_lanthipeptide NZ_CP031694.1 Lanthipeptides: allorf_3757607_3757789_lanthipeptide NZ_CP065790.1 Lanthipeptides: allorf_1228836_1229018_lanthipeptide NZ_CP072310.1 Lanthipeptides: allorf_3340146_3340328_lanthipeptide NZ_CP074685.1 Lanthipeptides: allorf_1220760_1220942_lanthipeptide NZ_CP075054.1 Lanthipeptides: allorf_2702843_2703025_lanthipeptide NZ_CP075054.1 Lanthipeptides: allorf_2702843_2703025_lanthipeptide NZ_CP088300.1 Lanthipeptides: allorf_1174611_1174793_lanthipeptide NZ_CP090905.1 Lanthipeptides: allorf_1201177_1201359_lanthipeptide NZ_CP094618.1 Lanthipeptides: allorf_1135121_1135303_lanthipeptide NZ_CP119675.1 Lanthipeptides: allorf_2182837_2183019_lanthipeptide NZ_LN999829.1 Lanthipeptides: allorf_1186077_1186259_lanthipeptide
Lanthipeptides: allorf_1238739_1238921_lanthipeptide
1
Q N S V S I T T Y P I T N H I C P T I T V G C A C P Q R Q V
30
Q N S V S I T T P I T N H+C P T I T V G C A C P Q R Q V
1
Q N S V S I T T I P I T N H V C P T I T V G C A C P Q R Q V
30
66.7%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10235_lanthipeptide
Lanthipeptides: J7E20_RS10235_lanthipeptide
1
Q N S V S I T T Y P I T N H I C P T I T V G C A C P Q R Q V
30
Q N +S I T T P T H+C T+T V G C A C P Q+Q+
1
Q N L I S I T T I P F T-H L C A T V T V G C A C P Q K Q I
29
with 3 more sequence matches
23.5%
NZ_CP048048.1 and 2 others:
NZ_CP048050.1 Lanthipeptides: GW570_RS15170_lanthipeptide NZ_CP088267.1 Lanthipeptides: LRE50_RS16510_lanthipeptide
Lanthipeptides: GW571_RS15175_lanthipeptide
8
T Y P I T N H I C P T I T V G C A C P Q R Q
29
T+ +T +C T I A C Q
8
T F K L T V K V C R T I I T T T A C G S T Q
29
20.0%
NZ_JANIOB010000033.1:
Lanthipeptides: NQ113_RS28010_lanthipeptide
11
I T N H I C P T I
19
T N +C P T I
15
F T N R L C P T I
23
15.8%
NZ_KB907258.1:
Lanthipeptides: G358_RS0114910_lanthipeptide
2
N S V S I T T Y P I T N H I C P T I T
20
N S+ I+ Y + C P++
6
N S I R I S I Y K C L S L F C P S V A
24

#### MIBiG 4.0 matches for allorf_107486_107668

13.3%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
18
T I T V G C
23
T+T V C
18
T L T V E C
23

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 23.52 out of 24.78
Confidence: strong
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.38 out of 26.06
Confidence: medium
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.57 out of 20.01
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.90 out of 27.78
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.27 out of 23.79
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.96 out of 28.19
Confidence: medium
Additional weak hits (4):
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.13 out of 30.22
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 26.26 out of 36.54
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.46 out of 30.11
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 20.85 out of 30.22
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

LQ568_RS00590 - Class II
  Cleavage pHMM score: 3.30
  RODEO score: 0
  Monoisotopic mass: 3389.7 Da
  Molecular weight: 3391.9 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3409.9 Da N = 1
    3427.9 Da N = 2
    3446.0 Da N = 3
    3464.0 Da N = 4
    3482.0 Da N = 5
    3500.0 Da N = 6
    3518.0 Da N = 7
    3536.1 Da N = 8
    3554.1 Da N = 9
LQ568_RS00595 - Class II
  Cleavage pHMM score: 3.30
  RODEO score: 0
  Monoisotopic mass: 3403.7 Da
  Molecular weight: 3405.9 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3423.9 Da N = 1
    3442.0 Da N = 2
    3460.0 Da N = 3
    3478.0 Da N = 4
    3496.0 Da N = 5
    3514.0 Da N = 6
    3532.1 Da N = 7
    3550.1 Da N = 8
    3568.1 Da N = 9
LQ568_RS00610 - Class II
  Cleavage pHMM score: -4.60
  RODEO score: 0
  Monoisotopic mass: 3892.7 Da
  Molecular weight: 3895.3 Da
  Number of bridges: 5
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3913.3 Da N = 1
allorf_101096_101173 - Class II
  Cleavage pHMM score: -5.60
  RODEO score: 0
  Monoisotopic mass: 1072.5 Da
  Molecular weight: 1073.2 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1091.2 Da N = 1
allorf_107486_107668 - Class II
  Cleavage pHMM score: 2.00
  RODEO score: 0
  Monoisotopic mass: 3117.6 Da
  Molecular weight: 3119.6 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3137.6 Da N = 1
    3155.6 Da N = 2
    3173.6 Da N = 3
    3191.6 Da N = 4
LQ568_RS00520 - Class II
  Cleavage pHMM score: -7.30
  RODEO score: 0
  Monoisotopic mass: 4455.4 Da
  Molecular weight: 4458.2 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4476.2 Da N = 1
LQ568_RS00590 - Class II
  Cleavage pHMM score: 3.30
  RODEO score: 0
  Monoisotopic mass: 3389.7 Da
  Molecular weight: 3391.9 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3409.9 Da N = 1
    3427.9 Da N = 2
    3446.0 Da N = 3
    3464.0 Da N = 4
    3482.0 Da N = 5
    3500.0 Da N = 6
    3518.0 Da N = 7
    3536.1 Da N = 8
    3554.1 Da N = 9
LQ568_RS00595 - Class II
  Cleavage pHMM score: 3.30
  RODEO score: 0
  Monoisotopic mass: 3403.7 Da
  Molecular weight: 3405.9 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3423.9 Da N = 1
    3442.0 Da N = 2
    3460.0 Da N = 3
    3478.0 Da N = 4
    3496.0 Da N = 5
    3514.0 Da N = 6
    3532.1 Da N = 7
    3550.1 Da N = 8
    3568.1 Da N = 9
LQ568_RS00610 - Class II
  Cleavage pHMM score: -4.60
  RODEO score: 0
  Monoisotopic mass: 3892.7 Da
  Molecular weight: 3895.3 Da
  Number of bridges: 5
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3913.3 Da N = 1
allorf_101096_101173 - Class II
  Cleavage pHMM score: -5.60
  RODEO score: 0
  Monoisotopic mass: 1072.5 Da
  Molecular weight: 1073.2 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1091.2 Da N = 1
allorf_107486_107668 - Class II
  Cleavage pHMM score: 2.00
  RODEO score: 0
  Monoisotopic mass: 3117.6 Da
  Molecular weight: 3119.6 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3137.6 Da N = 1
    3155.6 Da N = 2
    3173.6 Da N = 3
    3191.6 Da N = 4

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsR | Pleiotropic regulatory for antibiotic production
ArgR | Regulator of arginine biosynthesis genes
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
IolR | Regulator of the inositol catabolism
LexA variant 2 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
ZuR variant 1 | Zinc-responsive repressor

NZ_JAJNPN010000001.1 - Region 2 - NRPS,T3PKS,transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 145,967 - 263,908 nt. (total: 117,942 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
LQ568_RS00910: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

LQ568_RS19760: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acylase sulfhydrylase
LQ568_RS00955: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

LQ568_RS01000: O-succinylhomoserine sulfhydrylase

smcogs
  SMCOG1168: O-succinylhomoserine sulfhydrylase

LQ568_RS01005: O-succinylhomoserine sulfhydrylase

smcogs
  SMCOG1168: O-succinylhomoserine sulfhydrylase

Hydrolases: deacetylase esterase
LQ568_RS00865: polysaccharide deacetylase

smcogs
  SMCOG1235: polysaccharide deacetylase

LQ568_RS01010: enterobactin/ferric enterobactin esterase

smcogs
  SMCOG1098: enterobactin/ferric enterobactin esterase

Lyases: dehydratase
LQ568_RS00800: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: ligase synthase
LQ568_RS00905: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

LQ568_RS00915: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

LQ568_RS00940: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

LQ568_RS00950: hydroxymethylglutaryl-CoA synthase

smcogs
  SMCOG1043: hydroxymethylglutaryl-CoA synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | transAT-PKS | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | ---
BGC0002135.2 |  |  |  | 1.22 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001135.5 |  |  |  | 1.19 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001758.4 |  |  |  | 1.10 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001833.4 |  |  |  | 1.08 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.4 |  |  |  | 1.08 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  |  |  | 1.06 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001166.5 |  |  |  | 1.06 | NRPS | HC-toxin | Alternaria jesenskae
BGC0001132.4 |  |  |  | 1.05 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0000307.4 |  |  |  | 1.04 | NRPS | AbT1 | Aureobasidium pullulans
BGC0001825.4 |  |  |  | 1.03 | NRPS | xenematide | Xenorhabdus nematophila AN6/1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.75 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001135.5 |  | 0.74 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0000342.4 |  | 0.72 | NRPS | enniatin | Fusarium equiseti
BGC0001758.4 |  | 0.71 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001833.4 |  | 0.71 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.4 |  | 0.70 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001166.5 |  | 0.70 | NRPS | HC-toxin | Alternaria jesenskae
BGC0002286.3 |  | 0.70 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001261.3 |  | 0.69 | NRPS | AM-toxin | Alternaria alternata
BGC0000307.4 |  | 0.69 | NRPS | AbT1 | Aureobasidium pullulans

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.55 out of 18.46
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.52 out of 26.06
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.85 out of 20.97
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.11 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.67 out of 26.06
Confidence: medium
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 23.52 out of 26.33
Confidence: strong
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.69 out of 32.93
Confidence: medium
Additional weak hits (10):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.89 out of 26.06
Confidence: weak
BldD
Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.61 out of 23.43
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.00 out of 30.25
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.49 out of 36.54
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.01 out of 36.54
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.36 out of 30.11
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.05 out of 30.11
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.03 out of 29.25
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.62 out of 29.25
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.49 out of 32.93
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 145966 - 263908:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Thr - NMe-X) + (ohmal - mal - ohmal - mal - mal) + (Ala - Me-ccmal - mal - Gly - ohmal - mal) + (ccmal - mal - ccmal - mal) + (Ser - Ala)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
LQ568_RS00905: Ser - Ala
Search NORINE for peptide: strict or relaxed
AMP-binding (497..906): Ser
nrpys: Ser

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    ser (Ser)
  Single AA prediction:
    ser (Ser)

Stachelhaus prediction details:
  Stachelhaus sequence:
    RWMTFDVSVWELHFFCSGEFNLYGPTEAAIDVSH
  Nearest Stachelhaus code(s):
    Ser DVWHFSLIDK (91% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1596..2014): Ala
nrpys: Ala

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    TFLTFDVSVSEGNFMVAGEENIYGPTEASIYTTY
  Nearest Stachelhaus code(s):
    Ala DVSNMAIIYK (91% 8Å match)
  Stachelhaus code match:
    100% (strong)

LQ568_RS00915: Ala - Gly
Search NORINE for peptide: strict or relaxed
AMP-binding (489..905): Ala
nrpys: Ala

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    TFLTFDVSISEGNFMVAGEVNIYGPTEASIYAAY
  Nearest Stachelhaus code(s):
    Ala DVSNMAIIYK (88% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (4384..4787): Gly
nrpys: Gly

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    gly (Gly)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FSMTFDIAALELQALCGGEWNLYGPTETTVWSTV
  Nearest Stachelhaus code(s):
    Gly DILQLGLVWK (91% 8Å match)
  Stachelhaus code match:
    100% (strong)

LQ568_RS00940: Thr - X
Search NORINE for peptide: strict or relaxed
AMP-binding (512..919): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LATHFDFSVWEGNQIFGGEINMYGITETTVHVTY
  Nearest Stachelhaus code(s):
    Thr DFWNIGMVHK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1609..2013): X
nrpys: (unknown)

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LNPMFDVGSQEISLGVGGEVNAYGPTENSIASTC
  Nearest Stachelhaus code(s):
    Arg DVESIGAIAK (53% 8Å match)
  Stachelhaus code match:
    80% (moderate)

LQ568_RS00955: mal
PKS_AT (4..229): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 83.3%
  inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 56.3
  inactive: 29.0
  Methoxymalonyl-CoA: 14.2
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Propionyl-CoA: 0.0
  Methylmalonyl-CoA: 0.0
  Isobutyryl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
CcpA | Catabolite control protein A
LexA variant 3 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
RpoN | Regulator of nitrogen assimilation and virulence
ToxT | Regulator of MSHA biosynthesis

NZ_JAJNPN010000001.1 - Region 3 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 331,507 - 352,247 nt. (total: 20,741 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
LQ568_RS01495: oxidoreductase

smcogs
  SMCOG1079: oxidoreductase

Transferases: aminotransferase
LQ568_RS01480: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Hydrolases: hydrolase
LQ568_RS01520: asparagine synthase (glutamine-hydrolyzing)

smcogs
  SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002458.3 |  | 0.49 | NRPS | alazopeptin | Streptacidiphilus griseoplanus
BGC0000885.3 |  | 0.47 | other (other) | 4-hydroxy-3-nitrosobenzamide | Streptomyces murayamaensis
BGC0000846.5 |  | 0.44 | other (other) | tabtoxin | Pseudomonas syringae
BGC0001374.5 |  | 0.42 | other (other) | thienodolin | Streptomyces albogriseolus
BGC0001880.3 |  | 0.41 | ribosomal | scytodecamide | Scytonema sp. UIC 10036
BGC0001488.3 |  | 0.38 | other (other) | 4-formylaminooxyvinylglycine | Pseudomonas fluorescens WH6
BGC0002285.2 |  | 0.35 | ribosomal | aborycin | Streptomyces sp. ZS0098
BGC0001810.3 |  | 0.35 | PKS | trehangelin | Polymorphospora rubra
BGC0000720.3 |  | 0.35 | saccharide | tobramycin | Streptoalloteichus tenebrarius
BGC0001735.5 |  | 0.35 | other (other) | pentostatine, vidarabine | Streptomyces antibioticus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002458.3 |  | 0.49 | NRPS | alazopeptin | Streptacidiphilus griseoplanus
BGC0000885.3 |  | 0.47 | other (other) | 4-hydroxy-3-nitrosobenzamide | Streptomyces murayamaensis
BGC0000846.5 |  | 0.44 | other (other) | tabtoxin | Pseudomonas syringae
BGC0001374.5 |  | 0.42 | other (other) | thienodolin | Streptomyces albogriseolus
BGC0001880.3 |  | 0.41 | ribosomal | scytodecamide | Scytonema sp. UIC 10036
BGC0001488.3 |  | 0.38 | other (other) | 4-formylaminooxyvinylglycine | Pseudomonas fluorescens WH6
BGC0002285.2 |  | 0.35 | ribosomal | aborycin | Streptomyces sp. ZS0098
BGC0001810.3 |  | 0.35 | PKS | trehangelin | Polymorphospora rubra
BGC0000720.3 |  | 0.35 | saccharide | tobramycin | Streptoalloteichus tenebrarius
BGC0001735.5 |  | 0.35 | other (other) | pentostatine, vidarabine | Streptomyces antibioticus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene | C30 carotenoid | diapophytoene | C30 | acyclic | none
triterpene |  | squalene | C30 | acyclic | none
triterpene |  | PSPP | C30 | acyclic | PP
tetraterpene | C40 carotenoid | phytoene | C40 | acyclic | none
triterpene |  | hydroxysqualene | C30 | acyclic | OH

Genes with terpene domains:
LQ568_RS01515: PT_phytoene_like
Domain 1 (3 - 242): Prenyltransferase; Phytoene synthase like
Subtype: unknown

Reactions:
  FPP → diapophytoene
  FPP → squalene
  FPP → PSPP
  GGPP → phytoene
  PSPP → hydroxysqualene

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 20.47 out of 20.47
Confidence: strong
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 23.16 out of 26.33
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.88 out of 27.78
Confidence: medium
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.10 out of 26.85
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.27 out of 28.19
Confidence: medium
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 26.99 out of 35.63
Confidence: medium
Additional weak hits (5):
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.61 out of 30.22
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.44 out of 31.73
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.16 out of 26.06
Confidence: weak
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.38 out of 21.84
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.91 out of 32.74
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
FPP | Farnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
PP | Diphosphate
PSPP | Presqualene diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
NrtR | NAD synthesis repressor
RutR | Regulator of the pyrimidine and purine metabolism
VqsM | Regulator of quorum-sensing signalling systems
ZuR variant 1 | Zinc-responsive repressor

NZ_JAJNPN010000010.1 - Region 1 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 161,652 - 183,535 nt. (total: 21,884 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
LQ568_RS10050: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

Hydrolases: hydrolase
LQ568_RS10025: metallo-beta-lactamase family protein

smcogs
  SMCOG1170: metallo-beta-lactamase family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002173.2 |  | 0.46 | saccharide, terpene | fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol | Aspergillus fumigatus A1163
BGC0001535.3 |  | 0.42 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0000313.4 |  | 0.36 | NRPS | beauvericin | Beauveria bassiana
BGC0002255.3 |  | 0.33 | PKS | lijiquinone | Ascomycota sp. F53
BGC0000663.5 |  | 0.30 | terpene | hopene | Streptomyces coelicolor A3(2)
BGC0000686.3 |  | 0.30 | terpene | helvolic acid | Aspergillus fumigatus Af293
BGC0001575.4 |  | 0.29 | NRPS | PZN5, PZN6, PZN7, PZN9, PZN10, PZN11 | Ruminococcus sp. 5_1_39BFAA
BGC0001338.4 |  | 0.28 | PKS | citrinin | Monascus ruber
BGC0000154.4 |  | 0.28 | PKS | stipitatic acid | Talaromyces stipitatus ATCC 10500
BGC0001739.3 |  | 0.28 | other (other) | phosphonoacetic Acid | Streptomyces sp. NRRL F-525

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002173.2 |  | 0.46 | saccharide, terpene | fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol | Aspergillus fumigatus A1163
BGC0001535.3 |  | 0.42 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0000313.4 |  | 0.36 | NRPS | beauvericin | Beauveria bassiana
BGC0002255.3 |  | 0.33 | PKS | lijiquinone | Ascomycota sp. F53
BGC0000663.5 |  | 0.30 | terpene | hopene | Streptomyces coelicolor A3(2)
BGC0000686.3 |  | 0.30 | terpene | helvolic acid | Aspergillus fumigatus Af293
BGC0001575.4 |  | 0.29 | NRPS | PZN5, PZN6, PZN7, PZN9, PZN10, PZN11 | Ruminococcus sp. 5_1_39BFAA
BGC0001338.4 |  | 0.28 | PKS | citrinin | Monascus ruber
BGC0000154.4 |  | 0.28 | PKS | stipitatic acid | Talaromyces stipitatus ATCC 10500
BGC0001739.3 |  | 0.28 | other (other) | phosphonoacetic Acid | Streptomyces sp. NRRL F-525

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene | hopanoid |  | C30 | hopanoid skeleton | unknown
triterpene | polypodane |  | C30 | polypodane skeleton | unknown

Genes with terpene domains:
LQ568_RS10045: T2TS
Domain 1 (5 - 625): Type 2 terpene synthase
Subtype: Squalene substrate

Reactions:
  squalene → hopanoid
  squalene → polypodane

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.53 out of 26.06
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 26.30 out of 27.78
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.86 out of 27.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 28.19
Confidence: medium
Additional weak hits (5):
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.63 out of 25.75
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.14 out of 39.62
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.54 out of 26.06
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.10 out of 29.25
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.62 out of 21.55
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.
No acronyms to display
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_JAJNPN010000012.1 - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 88,938 - 116,911 nt. (total: 27,974 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase electron transfer oxidoreductase reductase
LQ568_RS10925: alkyl hydroperoxide reductase subunit

smcogs
  SMCOG1176: alkyl hydroperoxide reductase subunit

LQ568_RS10940: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

LQ568_RS10945: flavodoxin

smcogs
  SMCOG1134: flavodoxin

LQ568_RS10950: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

LQ568_RS10965: alcohol dehydrogenase

smcogs
  SMCOG1040: alcohol dehydrogenase

Ligases: synthase
LQ568_RS10960: cobalamin synthesis protein/P47K family protein

smcogs
  SMCOG1178: cobalamin synthesis protein/P47K family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.71 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001135.5 |  | 0.68 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0000342.4 |  | 0.68 | NRPS | enniatin | Fusarium equiseti
BGC0001825.4 |  | 0.68 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001833.4 |  | 0.68 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001132.4 |  | 0.67 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.4 |  | 0.66 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.66 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  | 0.65 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0000307.4 |  | 0.65 | NRPS | AbT1 | Aureobasidium pullulans

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.71 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001135.5 |  | 0.68 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0000342.4 |  | 0.68 | NRPS | enniatin | Fusarium equiseti
BGC0001825.4 |  | 0.68 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001833.4 |  | 0.68 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001132.4 |  | 0.67 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.4 |  | 0.66 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.66 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  | 0.65 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0000307.4 |  | 0.65 | NRPS | AbT1 | Aureobasidium pullulans

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.55 out of 29.38
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.80 out of 27.78
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.40 out of 20.97
Confidence: medium
Additional weak hits (9):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.89 out of 29.38
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.74 out of 32.74
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 23.23 out of 36.54
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.52 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.40 out of 26.06
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 23.04 out of 30.12
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.79 out of 20.01
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.84 out of 26.06
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 22.50 out of 35.63
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 88937 - 116911:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Glu - Leu)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
LQ568_RS11010: Glu - Leu
Search NORINE for peptide: strict or relaxed
AMP-binding (465..867): Glu
nrpys: Glu

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    gln (Gln)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LSLAFDASVKQADGLIGGETNVYGPTETCVDASV
  Nearest Stachelhaus code(s):
    Glu DAKDLGVVDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1511..1908): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TNTSFDAFMFDGMIMFGGELHMYGPSESTVFATY
  Nearest Stachelhaus code(s):
    Leu DAFMMGMVFK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1 | Ferric Uptake Regulator

NZ_JAJNPN010000013.1 - Region 1 - other
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 112,211 - 153,629 nt. (total: 41,419 nt) Show pHMM detection rules used
other: (Neocarzinostat or bcpB or frbD or mitE or prnB or CaiA or bacilysin or orf2_PTase)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
LQ568_RS11720: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

LQ568_RS11740: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

LQ568_RS11775: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

Transferases: aminotransferase transferase
LQ568_RS11725: aminotransferase

smcogs
  SMCOG1019: aminotransferase

LQ568_RS11805: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs
  SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

LQ568_RS11830: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs
  SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

Lyases: dehydratase lyase
LQ568_RS11735: argininosuccinate lyase/adenylosuccinate lyase

smcogs
  SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

LQ568_RS11795: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

LQ568_RS11800: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

Translocases: permease
LQ568_RS11630: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

LQ568_RS11765: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | other | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000888.5 |  | 0.97 | other (other) | bacilysin | Bacillus sp. CS93
BGC0001184.4 |  | 0.97 | other (other) | bacilysin | Bacillus velezensis FZB42
BGC0000898.5 |  | 0.56 | saccharide | desosamine, pikromycin, neomethymycin, narbomycin | Streptomyces venezuelae
BGC0000773.3 |  | 0.55 | saccharide | lipopolysaccharide | Escherichia coli
BGC0000790.3 |  | 0.54 | saccharide | O-antigen | Escherichia coli
BGC0000794.5 |  | 0.53 | saccharide | S-layer glycan | Geobacillus stearothermophilus
BGC0000791.3 |  | 0.53 | saccharide | O-antigen | Cronobacter sakazakii
BGC0000795.3 |  | 0.52 | saccharide | S-layer glycan | Aneurinibacillus thermoaerophilus
BGC0000899.4 |  | 0.52 | saccharide | desosamine | Streptomyces narbonensis
BGC0001817.5 |  | 0.52 | other (other) | vancosamine | Streptomyces sp. WAC2288

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000888.5 |  | 0.97 | other (other) | bacilysin | Bacillus sp. CS93
BGC0001184.4 |  | 0.97 | other (other) | bacilysin | Bacillus velezensis FZB42
BGC0000898.5 |  | 0.56 | saccharide | desosamine, pikromycin, neomethymycin, narbomycin | Streptomyces venezuelae
BGC0000773.3 |  | 0.55 | saccharide | lipopolysaccharide | Escherichia coli
BGC0000790.3 |  | 0.54 | saccharide | O-antigen | Escherichia coli
BGC0000794.5 |  | 0.53 | saccharide | S-layer glycan | Geobacillus stearothermophilus
BGC0000791.3 |  | 0.53 | saccharide | O-antigen | Cronobacter sakazakii
BGC0000795.3 |  | 0.52 | saccharide | S-layer glycan | Aneurinibacillus thermoaerophilus
BGC0000899.4 |  | 0.52 | saccharide | desosamine | Streptomyces narbonensis
BGC0001817.5 |  | 0.52 | other (other) | vancosamine | Streptomyces sp. WAC2288

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Location:
Identifier
Identity
Coverage
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.48 out of 18.57
Confidence: strong
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.22 out of 18.46
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.67 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.85 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.63 out of 27.78
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.75 out of 29.38
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.27 out of 27.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.75 out of 28.19
Confidence: medium
Additional weak hits (7):
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.62 out of 32.93
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.37 out of 20.01
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.29 out of 36.54
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 26.15 out of 36.54
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 21.66 out of 30.97
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.32 out of 26.06
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.68 out of 33.14
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1 | Ferric Uptake Regulator
MogR | Repressor of flagellar motility genes
RpoN | Regulator of nitrogen assimilation and virulence
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_JAJNPN010000015.1 - Region 1 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 93,026 - 116,214 nt. (total: 23,189 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
LQ568_RS13325: oxidoreductase

smcogs
  SMCOG1079: oxidoreductase

Lyases: cyclase
LQ568_RS13300: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000527.5 |  | 0.96 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0000554.4 |  | 0.56 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000528.5 |  | 0.56 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000626.3 |  | 0.53 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000516.4 |  | 0.53 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000539.5 |  | 0.53 | ribosomal | nukacin ISK-1 | Staphylococcus warneri
BGC0001210.5 |  | 0.52 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0001555.4 |  | 0.51 | ribosomal | colicin V | Escherichia coli chi7122
BGC0001787.3 |  | 0.51 | ribosomal | suicin 3908 | Streptococcus suis
BGC0000525.5 |  | 0.51 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000527.5 |  | 0.96 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0000554.4 |  | 0.56 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000528.5 |  | 0.56 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000626.3 |  | 0.53 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000516.4 |  | 0.53 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000539.5 |  | 0.53 | ribosomal | nukacin ISK-1 | Staphylococcus warneri
BGC0001210.5 |  | 0.52 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0001555.4 |  | 0.51 | ribosomal | colicin V | Escherichia coli chi7122
BGC0001787.3 |  | 0.51 | ribosomal | suicin 3908 | Streptococcus suis
BGC0000525.5 |  | 0.51 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for LQ568_RS13300

LQ568_RS13285
Leader:
MSQEAIIRSWKDPFSRENSTQNPAGNPFSELKEAQMDKLVGA
Core:
G D M E A A C T F T L P G G G G V C T L T S E C I C
Core with dehydrations:
G D M E A A Cys Dhb F Dhb L P G G G G V Cys Dhb L Dhb Dha E Cys I Cys

#### antiSMASH-DB 4.0 matches for LQ568_RS13285

100.0%
NC_017912.1 and 14 others:
NZ_CP007242.1 Lanthipeptides: KHU1_RS17410_lanthipeptide NZ_CP031424.1 Lanthipeptides: DXX91_RS18935_lanthipeptide NZ_CP032855.1 Lanthipeptides: D9C11_RS10440_lanthipeptide NZ_CP043809.1 Lanthipeptides: ETZ92_RS14260_lanthipeptide NZ_CP049904.1 Lanthipeptides: V753_RS18470_lanthipeptide NZ_CP053764.1 Lanthipeptides: HPQ66_RS18325_lanthipeptide NZ_CP061938.1 Lanthipeptides: IEN91_RS19800_lanthipeptide NZ_CP063768.1 Lanthipeptides: IM712_RS05205_lanthipeptide NZ_CP087137.1 Lanthipeptides: LOK79_RS18580_lanthipeptide NZ_CP092383.1 Lanthipeptides: MID02_RS19390_lanthipeptide NZ_JAEACM010000001.1 Lanthipeptides: I5F15_RS04355_lanthipeptide NZ_JAJNPN010000015.1 Lanthipeptides: LQ568_RS13285_lanthipeptide NZ_SDKF01000002.1 Lanthipeptides: EUA41_RS09950_lanthipeptide NZ_VDUT01000007.1 Lanthipeptides: FS412_RS14545_lanthipeptide
Lanthipeptides: MUS_RS20065_lanthipeptide
1
G D M E A A C T F T L P G G G G V C T L T S E C I C
26
G D M E A A C T F T L P G G G G V C T L T S E C I C
1
G D M E A A C T F T L P G G G G V C T L T S E C I C
26
96.2%
NZ_BORO01000007.1:
Lanthipeptides: KI343_RS07745_lanthipeptide
1
G D M E A A C T F T L P G G G G V C T L T S E C I C
26
G D M E A A C T+T L P G G G G V C T L T S E C I C
1
G D M E A A C T W T L P G G G G V C T L T S E C I C
26
92.3%
NZ_JALASB010000016.1 and 3 others:
NZ_JALASR010000012.1 Lanthipeptides: MOD87_RS16305_lanthipeptide NZ_JALAUW010000005.1 Lanthipeptides: MOE83_RS03160_lanthipeptide NZ_JALAXQ010000010.1 Lanthipeptides: MOF24_RS12150_lanthipeptide
Lanthipeptides: MOD42_RS18070_lanthipeptide
1
G D M E A A C T F T L P G G G G V C T L T S E C I C
26
G D M E A A C T+T L P G G G G V C T+T S E C I C
1
G D M E A A C T W T L P G G G G V C T I T S E C I C
26
with 98 more sequence matches
Only the first 10 are displayed here.
92.3%
NZ_KZ454939.1:
Lanthipeptides: CEF20_RS01155_lanthipeptide
1
G D M E A A C T F T L P G G G G V C T L T S E C I C
26
G D M E A A C T+T L P G G G G V C T+T S E C I C
1
G D M E A A C T W T L P G G G G V C T V T S E C I C
26
40.0%
NZ_CP047419.1 and 3 others:
NZ_CP047419.1 Lanthipeptides: GTU71_RS12805_lanthipeptide NZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15590_lanthipeptide NZ_PSTO01000045.1 Lanthipeptides: C5C10_RS15590_lanthipeptide
Lanthipeptides: GTU71_RS12805_lanthipeptide
8
T F T L P G----G G G V C T L T S E C
24
T F T L G G C T L T E C
5
T F T L S N V L G N Q G G W C T L T V E C
25
40.0%
NZ_CP084530.1 and 1 other:
NZ_CP084530.1 Lanthipeptides: LDO05_RS02075_lanthipeptide
Lanthipeptides: LDO05_RS02075_lanthipeptide
8
T F T L P G----G G G V C T L T S E C
24
T F T L G G C T L T E C
5
T F T L S N Y L G N N G G W C T L T K E C
25
40.0%
NZ_LT985747.1 and 1 other:
NZ_LT985747.1 Lanthipeptides: C8268_RS00165_lanthipeptide
Lanthipeptides: C8268_RS00165_lanthipeptide
8
T F T L P----G G G G V C T L T S E C
24
T F T L G G C T L T E C
5
T F T L S D Y L G N K G G W C T L T K E C
25
39.3%
NZ_FOBE01000018.1:
Lanthipeptides: BMW61_RS13085_lanthipeptide
2
D M E A A C T F T L P G G G G V C T L T S E C
24
+M A A L G C T L T E C
5
E M S A A----L G N R G S Y C T L T K E C
23
36.7%
NZ_MJEJ02000054.1 and 3 others:
NZ_MJEJ02000054.1 Lanthipeptides: BH683_RS28205_lanthipeptide NZ_QJSP01000005.1 Lanthipeptides: DFR67_RS09500_lanthipeptide NZ_QJSP01000005.1 Lanthipeptides: DFR67_RS09500_lanthipeptide
Lanthipeptides: BH683_RS28205_lanthipeptide
8
T F T L P----G G G G V C T L T S E
23
T F T L G G C T L T E
5
T F T L S D F L G N D G G W C T L T K E
24
35.3%
NZ_SDLS01000001.1:
Lanthipeptides: EIZ45_RS45960_lanthipeptide
2
D M E A A C T F T L P G G G G V C T L T S E C I C
26
D+ A T L P G +C T T E C C
10
D L A E A R T A A L P S S G Y I C T F T F E C N C
34
34.6%
NZ_CP034669.1:
Lanthipeptides: EJ065_RS32040_lanthipeptide
15
G G V C T L T S E C I C
26
G V C T L T+E C C
11
G Y V C T L T T E C G C
22
34.6%
NZ_CP035495.1 and 1 other:
NZ_CP035495.1 Lanthipeptides: ET495_RS17535_lanthipeptide
Lanthipeptides: ET495_RS17535_lanthipeptide
9
F T L P G G---G G V C T L T S E C
24
+T+P G G C T L+ E C
2
W T I P G T S T I G R F C T L S W E C
20
34.6%
NZ_JALMDK010000017.1:
Lanthipeptides: allorf_059288_059443_lanthipeptide
14
G G G V C T L T S E C I C
26
G G +C T L T E C C
3
G G Y I C T L T W E C N C
15

#### MIBiG 4.0 matches for LQ568_RS13285

30.0%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
11
L P G G G G V C T L T S E C
24
L G G C T L T E C
12
L G N N G G W C T L T K E C
25
28.6%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
11
L P G G G G V C T L T S E C I
25
L G C T L T E C+
10
L G N K G A Y C T L T V E C M
24
12.8%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
18
C T L T S E C
24
C T L+ E C
28
C T L S K E C
34

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.88 out of 27.78
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 16.62 out of 18.16
Confidence: strong
Additional weak hits (3):
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.98 out of 29.25
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 19.83 out of 30.11
Confidence: weak
RicR
Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 23.50 out of 32.93
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

LQ568_RS13285 - Class II
  Cleavage pHMM score: -2.00
  RODEO score: 0
  Monoisotopic mass: 2399.0 Da
  Molecular weight: 2400.8 Da
  Number of bridges: 3
  Additional modifications: AviCys
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2418.8 Da N = 1

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria

NZ_JAJNPN010000017.1 - Region 1 - NRPS,betalactone,transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 87,702 nt. (total: 87,702 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
betalactone: (HMGL-like and AMP-binding)
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxygenase
LQ568_RS13520: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

LQ568_RS13595: cytochrome P450

smcogs
  SMCOG1007: cytochrome P450

LQ568_RS13615: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

LQ568_RS13710: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

LQ568_RS13725: alcohol dehydrogenase

smcogs
  SMCOG1040: alcohol dehydrogenase

Transferases: acylase aminotransferase carboxylase transferase
LQ568_RS13530: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

LQ568_RS13550: acetyl-CoA carboxylase, carboxyl transferase,

smcogs
  SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

LQ568_RS13560: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs
  SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

LQ568_RS13575: aminotransferase class-III

smcogs
  SMCOG1013: aminotransferase class-III

LQ568_RS13620: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Lyases: hydratase
LQ568_RS13545: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase
LQ568_RS13500: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

LQ568_RS13505: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

LQ568_RS13525: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

LQ568_RS13540: 2-isopropylmalate synthase

smcogs
  SMCOG1271: 2-isopropylmalate synthase

LQ568_RS13580: 8-amino-7-oxononanoate synthase

smcogs
  SMCOG1109: 8-amino-7-oxononanoate synthase

LQ568_RS13625: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

LQ568_RS13630: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

LQ568_RS13635: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | betalactone | transAT-PKS | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | --- | ---
BGC0001090.5 |  |  |  |  | 1.64 | NRPS, PKS | bacillomycin D | Bacillus velezensis FZB42
BGC0001833.4 |  |  |  |  | 1.49 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002135.2 |  |  |  |  | 1.47 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001128.4 |  |  |  |  | 1.45 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4 |  |  |  |  | 1.44 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.4 |  |  |  |  | 1.43 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001098.5 |  |  |  |  | 1.43 | NRPS, PKS | iturin | Bacillus subtilis
BGC0002286.3 |  |  |  |  | 1.42 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  |  |  |  | 1.38 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001758.4 |  |  |  |  | 1.37 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001090.5 |  | 0.93 | NRPS, PKS | bacillomycin D | Bacillus velezensis FZB42
BGC0001098.5 |  | 0.84 | NRPS, PKS | iturin | Bacillus subtilis
BGC0000402.4 |  | 0.80 | NRPS | paenilarvin A, paenilarvin B, paenilarvin C | Paenibacillus larvae subsp. larvae DSM 25430
BGC0001103.5 |  | 0.77 | NRPS, PKS | mycosubtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001095.5 |  | 0.76 | NRPS | fengycin | Bacillus velezensis FZB42
BGC0001833.4 |  | 0.75 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002135.2 |  | 0.74 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001128.4 |  | 0.73 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4 |  | 0.73 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002075.3 |  | 0.73 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 20.32 out of 20.97
Confidence: strong
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 18.15 out of 18.46
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.29 out of 27.55
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.67 out of 26.06
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.83 out of 28.19
Confidence: medium
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.44 out of 32.93
Confidence: medium
Additional weak hits (7):
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.44 out of 20.47
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.74 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.46 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.66 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.52 out of 26.06
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.06 out of 29.38
Confidence: weak
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.01 out of 24.78
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 87702:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (D-Tyr) + (Ile) + (fatty_acid - mal - Asn - D-Tyr) + (D-Asn - Pro - Glu - D-Ser) + (Thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 27538:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (D-Tyr) + (Ile)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 10452 - 87702:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (fatty_acid - mal - Asn - D-Tyr) + (D-Asn - Pro - Glu - D-Ser) + (Thr)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
LQ568_RS13500: Tyr
Search NORINE for peptide: strict or relaxed
AMP-binding (178..570): Tyr
nrpys: Tyr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    Polar aromatic ring (Tyr, bOH-Tyr)
  Single AA prediction:
    tyr (Tyr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TWRFFDGFVTSTIITLAGEANEYGPTENSVATTA
  Nearest Stachelhaus code(s):
    Tyr DGTITAEVAK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

LQ568_RS13505: Ile
Search NORINE for peptide: strict or relaxed
AMP-binding (473..866): Ile
nrpys: Ile

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    ile (Ile)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LNSGFDAVTFEGFLYVGGEYNIYGPTENTTFSTF
  Nearest Stachelhaus code(s):
    Ile DAFFYGITFK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

LQ568_RS13525: X
AMP-binding (12..445): X
nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:
  Predicted physicochemical class:
    N/A
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    NNIVF-GCVLGAHGIMAGSTIAYGQTEASPVITQ
  Nearest Stachelhaus code(s):
    Z-ahmohOrn FGLHIASTCK (56% 8Å match)
    Ile DGLFIGIPVK (32% 8Å match)
  Stachelhaus code match:
    60% (weak)

LQ568_RS13620: mal
PKS_AT (6..290): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 62.5%
  inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 81.9
  inactive: 31.2
  Methoxymalonyl-CoA: 21.8
  Methylmalonyl-CoA: 13.2
  Propionyl-CoA: 12.9
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Isobutyryl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

LQ568_RS13625: fatty_acid - Asn
Search NORINE for peptide: strict or relaxed
CAL_domain (36..478): fatty_acid
minowa: fatty_acid

Prediction, score:
  fatty_acid: 624.6
  NH2: 18.6
  shikimic_acid: 0.0
  Acetyl-CoA: 0.0
  AHBA: 0.0

AMP-binding (2956..3351): Asn
nrpys: Asn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asn (Asn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWASFDLTVTSTKLIVGGEFNEYGPTEAVVGCMI
  Nearest Stachelhaus code(s):
    Asn DLTKIGEVGK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

LQ568_RS13630: Tyr - Asn - Pro - Glu
Search NORINE for peptide: strict or relaxed
AMP-binding (268..662): Tyr
nrpys: Tyr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    Polar aromatic ring (Tyr, bOH-Tyr)
  Single AA prediction:
    tyr (Tyr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    SWKYFDAFILNGSTVVGGENNEYGPTENSVVSTF
  Nearest Stachelhaus code(s):
    Tyr DALSVGEVVK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1779..2174): Asn
nrpys: Asn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asn (Asn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWASFDLTVTSTKLIVGGECNEYGPTETVVGCMI
  Nearest Stachelhaus code(s):
    Asn DLTKIGEVGK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (3286..3683): Pro
nrpys: Pro

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
  Small clusters prediction:
    pro (Pro)
  Single AA prediction:
    pro (Pro)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LDQAFDVCYQESFFITAGEHNHYGPSETHVVSTY
  Nearest Stachelhaus code(s):
    Pro DVQFIAHVVK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (4325..4732): Glu
nrpys: Glu

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    gln (Gln)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LGLAFDASVKQADGLIGGETNVYGPTETCVDASV
  Nearest Stachelhaus code(s):
    Glu DAKDLGVVDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

LQ568_RS13635: Ser - Thr
Search NORINE for peptide: strict or relaxed
AMP-binding (267..674): Ser
nrpys: Ser

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    ser (Ser)
  Single AA prediction:
    ser (Ser)

Stachelhaus prediction details:
  Stachelhaus sequence:
    RWMTFDVSVWEWHFFASGEINLYGPTEATIDVSY
  Nearest Stachelhaus code(s):
    Ser DVWHFSLIDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1789..2188): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LNNHFDFSVWEGNQIFGGEINMYGITETTVHVTY
  Nearest Stachelhaus code(s):
    Thr DFWNIGMVHK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
GnfM | Regulator of nitrogen-fixation genes
LexA variant 3 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
RpoN | Regulator of nitrogen assimilation and virulence
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_JAJNPN010000018.1 - Region 1 - transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 80,922 nt. (total: 80,922 nt) Show pHMM detection rules used
Region on contig edge.
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase oxygenase
LQ568_RS14020: 3-hydroxyisobutyrate dehydrogenase

smcogs
  SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

LQ568_RS14045: NADH:flavin oxidoreductase/NADH oxidase

smcogs
  SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

LQ568_RS14090: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

LQ568_RS14095: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

LQ568_RS14100: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

LQ568_RS14110: alcohol dehydrogenase

smcogs
  SMCOG1040: alcohol dehydrogenase

LQ568_RS14115: cytochrome P450

smcogs
  SMCOG1007: cytochrome P450

LQ568_RS14140: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

LQ568_RS14220: aldo/keto reductase family oxidoreductase

smcogs
  SMCOG1039: aldo/keto reductase family oxidoreductase

Transferases: acylase transferase
LQ568_RS13995: acetyl-CoA carboxylase, carboxyl transferase,

smcogs
  SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

LQ568_RS14070: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: deacetylase hydrolase
LQ568_RS14000: acetylornithine deacetylase

smcogs
  SMCOG1247: acetylornithine deacetylase

LQ568_RS14135: metallo-beta-lactamase family protein

smcogs
  SMCOG1170: metallo-beta-lactamase family protein

Lyases: hydratase
LQ568_RS14125: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase
LQ568_RS14085: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

LQ568_RS14105: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

LQ568_RS14120: hydroxymethylglutaryl-CoA synthase

smcogs
  SMCOG1043: hydroxymethylglutaryl-CoA synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | transAT-PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000176.5 |  | 0.73 | PKS | difficidin | Bacillus velezensis FZB42
BGC0001164.3 |  | 0.62 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0001160.5 |  | 0.61 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0001254.3 |  | 0.61 | PKS | ACT-Toxin II | Alternaria alternata
BGC0000174.5 |  | 0.58 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0002056.3 |  | 0.57 | NRPS, PKS | peloruside A | sponge metagenome
BGC0001795.3 |  | 0.53 | PKS | swinholide A | Nostoc sp. UHCC 0450
BGC0000067.5 |  | 0.53 | PKS | geldanamycin | Streptomyces hygroscopicus subsp. duamyceticus
BGC0000205.3 |  | 0.52 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0001201.3 |  | 0.52 | terpene | eremophilene | Sorangium cellulosum So ce56

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000176.5 |  | 0.73 | PKS | difficidin | Bacillus velezensis FZB42
BGC0001164.3 |  | 0.62 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0001160.5 |  | 0.61 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0001254.3 |  | 0.61 | PKS | ACT-Toxin II | Alternaria alternata
BGC0000174.5 |  | 0.58 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0002056.3 |  | 0.57 | NRPS, PKS | peloruside A | sponge metagenome
BGC0001795.3 |  | 0.53 | PKS | swinholide A | Nostoc sp. UHCC 0450
BGC0000067.5 |  | 0.53 | PKS | geldanamycin | Streptomyces hygroscopicus subsp. duamyceticus
BGC0000205.3 |  | 0.52 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0001201.3 |  | 0.52 | terpene | eremophilene | Sorangium cellulosum So ce56

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.22 out of 18.57
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.92 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.19 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.89 out of 27.78
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 23.96 out of 24.78
Confidence: strong
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.30 out of 25.31
Confidence: medium
Additional weak hits (9):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.08 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.45 out of 26.06
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.61 out of 30.25
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 21.46 out of 30.97
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.34 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.26 out of 26.06
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 22.13 out of 30.97
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 26.71 out of 30.97
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.89 out of 32.93
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 80922:
Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:
  (Me-ccmal - ccmal - ohmal - ccmal) + (ohmal - mal) + (Me-ccmal) + (mal)
Non-colinear ordering:
  LQ568_RS14095 + LQ568_RS14100 + LQ568_RS14105 + LQ568_RS14110

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
LQ568_RS14070: mal
PKS_AT (4..281): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 83.3%
  inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 87.7
  inactive: 30.9
  Methoxymalonyl-CoA: 29.3
  Methylmalonyl-CoA: 21.7
  Propionyl-CoA: 16.5
  2-Methylbutyryl-CoA: 15.4
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Isobutyryl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0

LQ568_RS14085: X
AMP-binding (15..363): X
nrpys: (unknown)

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    ALLLHIGGINTAPATYGTEKQTYGLTELGIFSTK
  Nearest Stachelhaus code(s):
    2,3-dohHda IGNPTGTIMK (74% 8Å match)
  Stachelhaus code match:
    90% (moderate)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CatR | H2O2-responsive repressor
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 2 | Repressor of DNA damage response
ToxT | Regulator of MSHA biosynthesis

NZ_JAJNPN010000002.1 - Region 1 - PKS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 39,591 nt. (total: 39,591 nt) Show pHMM detection rules used
Region on contig edge.
PKS-like: (t2pks2 or ksIII)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
LQ568_RS02160: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acyltransferase aminotransferase
LQ568_RS02115: aminotransferase

smcogs
  SMCOG1019: aminotransferase

LQ568_RS02130: acyltransferase

smcogs
  SMCOG1141: acyltransferase

Hydrolases: deacetylase
LQ568_RS02070: polysaccharide deacetylase

smcogs
  SMCOG1235: polysaccharide deacetylase

Ligases: synthase
LQ568_RS02110: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

Translocases: permease
LQ568_RS02155: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | PKS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002276.2 |  | 0.55 | NRPS | choline | Aspergillus nidulans FGSC A4
BGC0001928.2 |  | 0.50 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0002404.2 |  | 0.45 | other (other) | falcarindiol | Solanum lycopersicum
BGC0002294.3 |  | 0.43 | other (other) | streptozotocin | Streptomyces achromogenes subsp. streptozoticus
BGC0000205.3 |  | 0.43 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0002150.2 |  | 0.42 | ribosomal | triculamin | Streptomyces triculaminicus
BGC0002151.2 |  | 0.42 | ribosomal | alboverticillin | Streptomyces griseocarneus
BGC0001292.5 |  | 0.42 | other (other) | A33853 | Streptomyces sp. NRRL 12068
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000623.3 |  | 0.42 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002276.2 |  | 0.55 | NRPS | choline | Aspergillus nidulans FGSC A4
BGC0001928.2 |  | 0.50 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0002404.2 |  | 0.45 | other (other) | falcarindiol | Solanum lycopersicum
BGC0002294.3 |  | 0.43 | other (other) | streptozotocin | Streptomyces achromogenes subsp. streptozoticus
BGC0000205.3 |  | 0.43 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0002150.2 |  | 0.42 | ribosomal | triculamin | Streptomyces triculaminicus
BGC0002151.2 |  | 0.42 | ribosomal | alboverticillin | Streptomyces griseocarneus
BGC0001292.5 |  | 0.42 | other (other) | A33853 | Streptomyces sp. NRRL 12068
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000623.3 |  | 0.42 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.50 out of 23.79
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.52 out of 26.06
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 25.91 out of 27.55
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.88 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.01 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.81 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.75 out of 27.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.83 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.27 out of 28.19
Confidence: medium
Additional weak hits (12):
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.59 out of 30.11
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.41 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.75 out of 26.06
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.28 out of 28.14
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.34 out of 30.25
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.97 out of 28.14
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.67 out of 26.06
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.28 out of 28.14
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.22 out of 26.06
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.48 out of 29.38
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.02 out of 28.14
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.32 out of 33.14
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM | Regulator of nitrogen-fixation genes
IolR | Regulator of the inositol catabolism
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_JAJNPN010000021.1 - Region 1 - HR-T2PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 29,526 nt. (total: 29,526 nt) Show pHMM detection rules used
Region on contig edge.
HR-T2PKS: (hr-t2pks-ksa and (t2fas or APE_KS2 or ketoacyl-synt))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
LQ568_RS15090: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Hydrolases: amidase
LQ568_RS15150: amidase

smcogs
  SMCOG1105: amidase

Ligases: synthase
LQ568_RS15100: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | HR-T2PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000888.5 |  | 0.48 | other (other) | bacilysin | Bacillus sp. CS93
BGC0000231.5 |  | 0.46 | PKS | griseusin A, griseusin B | Streptomyces griseus
BGC0002404.2 |  | 0.46 | other (other) | falcarindiol | Solanum lycopersicum
BGC0001987.2 |  | 0.46 | PKS | koreenceine A, koreenceine B, koreenceine C, koreenceine D | Pseudomonas koreensis
BGC0001184.4 |  | 0.46 | other (other) | bacilysin | Bacillus velezensis FZB42
BGC0001197.5 |  | 0.45 | PKS | frankiamicin | Frankia sp. EAN1pec
BGC0000948.5 |  | 0.45 | other (other) | α-galactosylceramide | Bacteroides fragilis NCTC 9343
BGC0000234.5 |  | 0.44 | PKS | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000204.5 |  | 0.44 | PKS | benastatin A, benastatin B, BE-43767, TAN1532B | Streptomyces sp. A2991200
BGC0000272.3 |  | 0.43 | PKS | spore pigment | Streptomyces collinus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000888.5 |  | 0.48 | other (other) | bacilysin | Bacillus sp. CS93
BGC0000231.5 |  | 0.46 | PKS | griseusin A, griseusin B | Streptomyces griseus
BGC0002404.2 |  | 0.46 | other (other) | falcarindiol | Solanum lycopersicum
BGC0001987.2 |  | 0.46 | PKS | koreenceine A, koreenceine B, koreenceine C, koreenceine D | Pseudomonas koreensis
BGC0001184.4 |  | 0.46 | other (other) | bacilysin | Bacillus velezensis FZB42
BGC0001197.5 |  | 0.45 | PKS | frankiamicin | Frankia sp. EAN1pec
BGC0000948.5 |  | 0.45 | other (other) | α-galactosylceramide | Bacteroides fragilis NCTC 9343
BGC0000234.5 |  | 0.44 | PKS | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000204.5 |  | 0.44 | PKS | benastatin A, benastatin B, BE-43767, TAN1532B | Streptomyces sp. A2991200
BGC0000272.3 |  | 0.43 | PKS | spore pigment | Streptomyces collinus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.05 out of 20.97
Confidence: strong
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.63 out of 26.85
Confidence: strong
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16
Confidence: strong
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 18.15 out of 18.46
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.63 out of 27.78
Confidence: medium
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.58 out of 21.84
Confidence: medium
Additional weak hits (1):
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.41 out of 30.11
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MexT | Global virulence regulator
RpoN | Regulator of nitrogen assimilation and virulence
RutR | Regulator of the pyrimidine and purine metabolism
ToxT | Regulator of MSHA biosynthesis

NZ_JAJNPN010000024.1 - Region 1 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 49,345 - 70,235 nt. (total: 20,891 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: carboxylase
LQ568_RS16280: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase
LQ568_RS16310: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

LQ568_RS16315: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002284.3 |  | 0.38 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000639.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0000638.3 |  | 0.37 | terpene | carotenoid | Pantoea ananatis
BGC0000640.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC404

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002284.3 |  | 0.38 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000639.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0000638.3 |  | 0.37 | terpene | carotenoid | Pantoea ananatis
BGC0000640.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC404

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
LQ568_RS16310: PT_FPPS_like
Domain 1 (33 - 296): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  DMAPP, IPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.59 out of 30.25
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.14 out of 27.78
Confidence: medium
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.81 out of 29.25
Confidence: medium
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator
SypG | Regulator of biofilm formation and host colonization

NZ_JAJNPN010000003.1 - Region 1 - NRP-metallophore,NRPS,RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 32,786 - 84,578 nt. (total: 51,793 nt) Show pHMM detection rules used
NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase reductase
LQ568_RS02475: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

LQ568_RS02550: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

LQ568_RS02600: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

LQ568_RS02605: alkyl hydroperoxide reductase subunit

smcogs
  SMCOG1176: alkyl hydroperoxide reductase subunit

LQ568_RS02655: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acetyltransferase
LQ568_RS02650: GCN5-related N-acetyltransferase

smcogs
  SMCOG1111: GCN5-related N-acetyltransferase

Hydrolases: hydrolase
LQ568_RS02440: isochorismatase

smcogs
  SMCOG1027: isochorismatase

LQ568_RS02535: isochorismatase

smcogs
  SMCOG1027: isochorismatase

Isomerases: isomerase
LQ568_RS02545: isochorismate synthase

smcogs
  SMCOG1018: isochorismate synthase

Ligases: ligase
LQ568_RS02530: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

LQ568_RS02540: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRP-metallophore | NRPS | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | ---
BGC0000616.4 |  |  |  | 2.41 | ribosomal | amylocyclicin | Bacillus velezensis FZB42
BGC0001185.5 |  |  |  | 1.57 | NRPS | bacillibactin | Bacillus velezensis FZB42
BGC0000309.5 |  |  |  | 1.07 | NRPS | bacillibactin | Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5 |  |  |  | 1.04 | NRPS | paenibactin | Paenibacillus elgii B69
BGC0002075.3 |  |  |  | 0.87 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0000343.5 |  |  |  | 0.86 | NRPS | enterobactin | Pseudomonas sp. J465
BGC0001132.4 |  |  |  | 0.77 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  |  |  | 0.76 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.4 |  |  |  | 0.75 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4 |  |  |  | 0.74 | NRPS | xenematide | Xenorhabdus nematophila AN6/1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000616.4 |  | 0.95 | ribosomal | amylocyclicin | Bacillus velezensis FZB42
BGC0001185.5 |  | 0.92 | NRPS | bacillibactin | Bacillus velezensis FZB42
BGC0000309.5 |  | 0.81 | NRPS | bacillibactin | Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5 |  | 0.80 | NRPS | paenibactin | Paenibacillus elgii B69
BGC0002075.3 |  | 0.74 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0000343.5 |  | 0.74 | NRPS | enterobactin | Pseudomonas sp. J465
BGC0001132.4 |  | 0.71 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  | 0.70 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.4 |  | 0.70 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4 |  | 0.70 | NRPS | xenematide | Xenorhabdus nematophila AN6/1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.62 out of 18.16
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 29.38 out of 29.38
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.61 out of 29.38
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 27.15 out of 29.38
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.87 out of 27.78
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.49 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.91 out of 29.38
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.52 out of 27.78
Confidence: medium
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.23 out of 21.55
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.11 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.89 out of 27.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.73 out of 28.19
Confidence: strong
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.18 out of 28.19
Confidence: medium
Additional weak hits (18):
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.44 out of 31.73
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.84 out of 29.25
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.61 out of 32.74
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.12 out of 29.38
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.52 out of 32.74
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.31 out of 29.38
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.58 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.08 out of 26.06
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.44 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.15 out of 26.06
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.10 out of 29.25
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.86 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.13 out of 26.06
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.99 out of 33.14
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 21.63 out of 30.12
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 32785 - 84578:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 32785 - 84522:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
LQ568_RS02530: Gly - Thr
Search NORINE for peptide: strict or relaxed
AMP-binding (456..855): Gly
nrpys: Gly

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    gly (Gly)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FSMTFDISGLELQALVGGETNLYGPTETTIWSAA
  Nearest Stachelhaus code(s):
    Gly DILQLGLIWK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1513..1929): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LSTHFDFSVWEGNQIFGGEVNMYGITETTVHVSY
  Nearest Stachelhaus code(s):
    Thr DFWNIGMVHK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

LQ568_RS02540: diOH-Bz
Search NORINE for peptide: strict or relaxed
AMP-binding (31..435): diOH-Bz
nrpys: diOH-Bz

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Small clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Single AA prediction:
    dhb (diOH-Bz)

Stachelhaus prediction details:
  Stachelhaus sequence:
    SISLYPLSSPGGALQVGGAQQVFGMAEGLVNYTR
  Nearest Stachelhaus code(s):
    diOH-Bz PLPAQGVVNK (100% 8Å match)
    diOH-Bz or Sal PLPAQGVVNK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
ArcA | Repressor of carbon oxidation
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1 | Ferric Uptake Regulator
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_JAJNPN010000043.1 - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 10,260 nt. (total: 10,260 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Ligases: ligase
LQ568_RS19300: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

LQ568_RS19305: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.71 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0000396.5 |  | 0.71 | NRPS | nodularin | Nostoc sp. 73.1
BGC0001261.3 |  | 0.70 | NRPS | AM-toxin | Alternaria alternata
BGC0001135.5 |  | 0.69 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001132.4 |  | 0.69 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0000342.4 |  | 0.68 | NRPS | enniatin | Fusarium equiseti
BGC0001825.4 |  | 0.68 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001833.4 |  | 0.68 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001166.5 |  | 0.68 | NRPS | HC-toxin | Alternaria jesenskae
BGC0000426.5 |  | 0.68 | NRPS | sevadicin | Paenibacillus larvae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.71 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0000396.5 |  | 0.71 | NRPS | nodularin | Nostoc sp. 73.1
BGC0001261.3 |  | 0.70 | NRPS | AM-toxin | Alternaria alternata
BGC0001135.5 |  | 0.69 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001132.4 |  | 0.69 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0000342.4 |  | 0.68 | NRPS | enniatin | Fusarium equiseti
BGC0001825.4 |  | 0.68 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001833.4 |  | 0.68 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001166.5 |  | 0.68 | NRPS | HC-toxin | Alternaria jesenskae
BGC0000426.5 |  | 0.68 | NRPS | sevadicin | Paenibacillus larvae

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 10260:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (D-X) + (Pro - Gln)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
LQ568_RS19300: X
AMP-binding (179..572): X
nrpys: Ala, Val

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    val (Val)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LNSSFDVTTFEGWLIIGGEWNGYGPTENTTFSTC
  Nearest Stachelhaus code(s):
    Ala or Val DVFWIGGTFK (97% 8Å match)
    Val DVFWIGGTFK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

LQ568_RS19305: Pro - Gln
Search NORINE for peptide: strict or relaxed
AMP-binding (469..866): Pro
nrpys: Pro

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
  Small clusters prediction:
    pro (Pro)
  Single AA prediction:
    pro (Pro)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LDQAFDVCYQESFFITAGEHNHYGPSETHVVSTY
  Nearest Stachelhaus code(s):
    Pro DVQFIAHVVK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1500..1901): Gln
nrpys: Gln

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    glu (Glu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FSLTFDASIWEWHFFAGGETNSYGPTEATVEAAY
  Nearest Stachelhaus code(s):
    Gln DAWHFGSVEK (100% 8Å match)
    Glu DAWHFGSVEK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
NZ_JAJNPN010000045.1 - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 8,995 nt. (total: 8,995 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Ligases: ligase
LQ568_RS19330: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

LQ568_RS19335: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

LQ568_RS19755: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.71 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001261.3 |  | 0.70 | NRPS | AM-toxin | Alternaria alternata
BGC0000342.4 |  | 0.68 | NRPS | enniatin | Fusarium equiseti
BGC0001135.5 |  | 0.68 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001132.4 |  | 0.68 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001166.5 |  | 0.68 | NRPS | HC-toxin | Alternaria jesenskae
BGC0001833.4 |  | 0.68 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  | 0.68 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0002286.3 |  | 0.67 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  | 0.67 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.71 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001261.3 |  | 0.70 | NRPS | AM-toxin | Alternaria alternata
BGC0000342.4 |  | 0.68 | NRPS | enniatin | Fusarium equiseti
BGC0001135.5 |  | 0.68 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001132.4 |  | 0.68 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001166.5 |  | 0.68 | NRPS | HC-toxin | Alternaria jesenskae
BGC0001833.4 |  | 0.68 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  | 0.68 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0002286.3 |  | 0.67 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  | 0.67 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 8995:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Val) + (Asp)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
LQ568_RS19755: Asp
Search NORINE for peptide: strict or relaxed
AMP-binding (437..839): Asp
nrpys: Asp

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asp (Asp)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWFSFDLGYTAPKLVLGGEINHYGPTETTIGAIA
  Nearest Stachelhaus code(s):
    Asp DLTKVGHIGK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

LQ568_RS19330: Val
Search NORINE for peptide: strict or relaxed
AMP-binding (470..864): Val
nrpys: Val

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    val (Val)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LHSGFDAGTFEGWLIIGGDWNGYGPTENTTFSTS
  Nearest Stachelhaus code(s):
    Val DAFWIGGTFK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
NZ_JAJNPN010000005.1 - Region 1 - transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 57,645 - 145,875 nt. (total: 88,231 nt) Show pHMM detection rules used
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase
LQ568_RS05095: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

LQ568_RS05105: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

LQ568_RS05110: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

LQ568_RS05120: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

LQ568_RS05155: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Transferases: acylase kinase
LQ568_RS04990: PfkB domain protein

smcogs
  SMCOG1276: PfkB domain protein

LQ568_RS05090: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: deacetylase deformylase hydrolase phosphatase
LQ568_RS05070: hydrolase

smcogs
  SMCOG1179: hydrolase

LQ568_RS05075: peptide deformylase

smcogs
  SMCOG1275: peptide deformylase

LQ568_RS05135: beta-lactamase

smcogs
  SMCOG1053: beta-lactamase

LQ568_RS05165: polysaccharide deacetylase

smcogs
  SMCOG1235: polysaccharide deacetylase

LQ568_RS05195: inositol monophosphatase

smcogs
  SMCOG1207: inositol monophosphatase

Ligases: synthase
LQ568_RS05100: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

LQ568_RS05145: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | transAT-PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000181.5 |  | 0.88 | PKS | macrolactin H | Bacillus velezensis FZB42
BGC0001383.3 |  | 0.88 | PKS | macrolactin H, macrolactin B, macrolactin 1c, macrolactin E | Jeotgalibacillus marinus
BGC0001534.3 |  | 0.70 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0001276.3 |  | 0.64 | PKS | 6-methylsalicyclic acid | Aspergillus terreus
BGC0001244.3 |  | 0.64 | PKS | (-)-Mellein | Parastagonospora nodorum
BGC0001275.3 |  | 0.64 | PKS | 6-methylsalicyclic acid | Glarea lozoyensis
BGC0001273.3 |  | 0.63 | PKS | asperlactone | Aspergillus ochraceus
BGC0001284.4 |  | 0.63 | PKS | alternariol | Parastagonospora nodorum SN15
BGC0001254.3 |  | 0.62 | PKS | ACT-Toxin II | Alternaria alternata
BGC0001164.3 |  | 0.61 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000181.5 |  | 0.88 | PKS | macrolactin H | Bacillus velezensis FZB42
BGC0001383.3 |  | 0.88 | PKS | macrolactin H, macrolactin B, macrolactin 1c, macrolactin E | Jeotgalibacillus marinus
BGC0001534.3 |  | 0.70 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0001276.3 |  | 0.64 | PKS | 6-methylsalicyclic acid | Aspergillus terreus
BGC0001244.3 |  | 0.64 | PKS | (-)-Mellein | Parastagonospora nodorum
BGC0001275.3 |  | 0.64 | PKS | 6-methylsalicyclic acid | Glarea lozoyensis
BGC0001273.3 |  | 0.63 | PKS | asperlactone | Aspergillus ochraceus
BGC0001284.4 |  | 0.63 | PKS | alternariol | Parastagonospora nodorum SN15
BGC0001254.3 |  | 0.62 | PKS | ACT-Toxin II | Alternaria alternata
BGC0001164.3 |  | 0.61 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.63 out of 27.78
Confidence: strong
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.94 out of 21.55
Confidence: medium
Additional weak hits (8):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.30 out of 26.06
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.56 out of 29.38
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.27 out of 30.22
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.65 out of 29.25
Confidence: weak
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.35 out of 26.33
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.20 out of 31.73
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.94 out of 29.65
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.99 out of 33.14
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 57644 - 145875:
Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:
  (ohmal - ccmal - ccmal) + (ccmal) + (ccmal - mal) + (ccmal - mal) + (ohmal) + (ohmal - mal)
Non-colinear ordering:
  LQ568_RS05095 + LQ568_RS05100 + LQ568_RS05105 + LQ568_RS05110 + LQ568_RS05115 + LQ568_RS05120 + LQ568_RS19785

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
LQ568_RS05090: mal
PKS_AT (4..282): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 75.0%
  inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 92.6
  inactive: 32.0
  Methoxymalonyl-CoA: 28.0
  Methylmalonyl-CoA: 20.8
  Propionyl-CoA: 17.4
  fatty_acid: 13.9
  trans-1,2-CPDA: 0.0
  Isobutyryl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArcA | Repressor of carbon oxidation
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ToxT | Regulator of MSHA biosynthesis

NZ_JAJNPN010000005.1 - Region 2 - NRPS,T3PKS,transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 368,599 - 405,834 nt. (total: 37,236 nt) Show pHMM detection rules used
Region on contig edge.
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
LQ568_RS06345: alcohol dehydrogenase

smcogs
  SMCOG1040: alcohol dehydrogenase

Transferases: acylase
LQ568_RS06405: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

LQ568_RS06410: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

LQ568_RS06415: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: hydrolase
LQ568_RS06325: beta-lactamase

smcogs
  SMCOG1053: beta-lactamase

LQ568_RS06400: metallo-beta-lactamase family protein

smcogs
  SMCOG1170: metallo-beta-lactamase family protein

Lyases: hydratase
LQ568_RS06430: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

LQ568_RS06435: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase
LQ568_RS06350: 8-amino-7-oxononanoate synthase

smcogs
  SMCOG1109: 8-amino-7-oxononanoate synthase

LQ568_RS06425: hydroxymethylglutaryl-CoA synthase

smcogs
  SMCOG1043: hydroxymethylglutaryl-CoA synthase

LQ568_RS06440: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | transAT-PKS | T3PKS | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | ---
BGC0002135.2 |  |  |  | 0.99 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001135.5 |  |  |  | 0.94 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001132.4 |  |  |  | 0.91 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  |  |  | 0.91 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  |  |  | 0.90 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001128.4 |  |  |  | 0.90 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  |  |  | 0.89 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001275.3 |  |  |  | 0.87 | PKS | 6-methylsalicyclic acid | Glarea lozoyensis
BGC0001758.4 |  |  |  | 0.86 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001244.3 |  |  |  | 0.86 | PKS | (-)-Mellein | Parastagonospora nodorum

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.66 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001135.5 |  | 0.65 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001132.4 |  | 0.64 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  | 0.64 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  | 0.64 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001128.4 |  | 0.63 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.63 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001275.3 |  | 0.63 | PKS | 6-methylsalicyclic acid | Glarea lozoyensis
BGC0001758.4 |  | 0.62 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001244.3 |  | 0.62 | PKS | (-)-Mellein | Parastagonospora nodorum

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 24.56 out of 29.25
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.78 out of 20.97
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.62 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.14 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.60 out of 26.06
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.59 out of 30.25
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.30 out of 24.78
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.14 out of 18.16
Confidence: strong
Additional weak hits (9):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.51 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.96 out of 26.06
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.16 out of 32.74
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.22 out of 28.14
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.08 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.45 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.67 out of 26.06
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 26.07 out of 39.62
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.67 out of 26.06
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 368598 - 405834:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (fatty_acid - Gly - ccmal)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
LQ568_RS06405: mal
PKS_AT (4..285): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 87.5%
  inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 100.0
  inactive: 46.8
  Methoxymalonyl-CoA: 38.9
  Methylmalonyl-CoA: 25.3
  Propionyl-CoA: 23.1
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Isobutyryl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

LQ568_RS06410: mal
PKS_AT (7..293): mal
ATSignature: (unknown)
No matches above 50%
minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 36.5
  inactive: 26.2
  Methoxymalonyl-CoA: 14.3
  Benzoyl-CoA: 13.9
  Methylmalonyl-CoA: 9.2
  Isobutyryl-CoA: 8.8
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Propionyl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

LQ568_RS06415: mal
PKS_AT (4..282): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 87.5%
  inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 87.4
  inactive: 28.2
  Methoxymalonyl-CoA: 23.4
  Methylmalonyl-CoA: 10.9
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Propionyl-CoA: 0.0
  Isobutyryl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

LQ568_RS06440: fatty_acid - Gly
Search NORINE for peptide: strict or relaxed
CAL_domain (74..476): fatty_acid
minowa: fatty_acid

Prediction, score:
  fatty_acid: 26.0
  NH2: 9.4
  shikimic_acid: 0.0
  Acetyl-CoA: 0.0
  AHBA: 0.0

AMP-binding (1145..1540): Gly
nrpys: Gly

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    gly (Gly)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FSMTFDIAALELQALCGGEWNMFGPTETTIWSAV
  Nearest Stachelhaus code(s):
    Gly DILQLGMIWK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator
LexA variant 2 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
SypG | Regulator of biofilm formation and host colonization
ToxT | Regulator of MSHA biosynthesis

NZ_JAJNPN010000006.1 - Region 1 - NRPS,transAT-PKS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 67,732 nt. (total: 67,732 nt) Show pHMM detection rules used
Region on contig edge.
transAT-PKS-like: cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS) and not PKS_AT)
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxygenase
LQ568_RS06450: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

LQ568_RS06470: cytochrome P450

smcogs
  SMCOG1007: cytochrome P450

Hydrolases: protease
LQ568_RS06490: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Ligases: ligase synthase
LQ568_RS06455: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

LQ568_RS06460: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

LQ568_RS06465: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | transAT-PKS-like | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001089.5 |  |  | 0.53 | NRPS, PKS | bacillaene | Bacillus velezensis FZB42
BGC0001160.5 |  |  | 0.50 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0001164.3 |  |  | 0.50 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0002631.2 |  |  | 0.41 | ribosomal | Myxarylin | Pyxidicoccus fallax
BGC0000174.5 |  |  | 0.40 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0001310.5 |  |  | 0.37 | PKS | naringenin | Streptomyces clavuligerus ATCC 27064
BGC0001050.5 |  |  | 0.36 | NRPS, PKS | thalassospiramide A | Tistrella bauzanensis
BGC0002056.3 |  |  | 0.34 | NRPS, PKS | peloruside A | sponge metagenome
BGC0001109.4 |  |  | 0.34 | NRPS, PKS | pederin | unidentified unclassified sequences.
BGC0002127.3 |  |  | 0.33 | PKS | flaviolin, 1,3,6,8-tetrahydroxynaphthalene | Streptomyces coelicolor A3(2)

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001089.5 |  | 0.65 | NRPS, PKS | bacillaene | Bacillus velezensis FZB42
BGC0001273.3 |  | 0.61 | PKS | asperlactone | Aspergillus ochraceus
BGC0001244.3 |  | 0.61 | PKS | (-)-Mellein | Parastagonospora nodorum
BGC0001275.3 |  | 0.61 | PKS | 6-methylsalicyclic acid | Glarea lozoyensis
BGC0000174.5 |  | 0.60 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0001160.5 |  | 0.59 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0001164.3 |  | 0.59 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0001284.4 |  | 0.58 | PKS | alternariol | Parastagonospora nodorum SN15
BGC0002631.2 |  | 0.53 | ribosomal | Myxarylin | Pyxidicoccus fallax
BGC0001310.5 |  | 0.50 | PKS | naringenin | Streptomyces clavuligerus ATCC 27064

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.31 out of 25.88
Confidence: medium
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.47 out of 21.55
Confidence: strong
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 22.51 out of 24.78
Confidence: strong
Additional weak hits (3):
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.04 out of 30.25
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.39 out of 30.25
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.54 out of 36.54
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 67732:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (ohmal - mal) + (ccmal - mal - ohmal - mal) + (Me-ccmal - ohmal) + (Ala - ccmal - ccmal - Me-ccmal) + (mal - mal)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
LQ568_RS06460: Ala
Search NORINE for peptide: strict or relaxed
AMP-binding (492..896): Ala
nrpys: Ala

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    TFLTFDVSISEGNFMVAGEENIYGPTETSIYAAY
  Nearest Stachelhaus code(s):
    Ala DVSNMAIIYK (88% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArcA | Repressor of carbon oxidation
LexA variant 2 | Repressor of DNA damage response
PsrA | Oleic acid responsive regulator

NZ_JAJNPN010000009.1 - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 185,851 - 211,054 nt. (total: 25,204 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
LQ568_RS08950: oxidoreductase

smcogs
  SMCOG1083: oxidoreductase

Transferases: PPTase aminotransferase
LQ568_RS09030: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

LQ568_RS09035: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Hydrolases: esterase
LQ568_RS09040: thioesterase

smcogs
  SMCOG1004: thioesterase

Ligases: ligase
LQ568_RS09045: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

LQ568_RS09050: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001132.4 |  | 0.67 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.4 |  | 0.67 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001833.4 |  | 0.67 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002286.3 |  | 0.66 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  | 0.66 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  | 0.66 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001641.4 |  | 0.65 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  | 0.63 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0000357.5 |  | 0.63 | NRPS | cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val) | Penicillium rubens Wisconsin 54-1255
BGC0002135.2 |  | 0.63 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001132.4 |  | 0.67 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.4 |  | 0.67 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001833.4 |  | 0.67 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002286.3 |  | 0.66 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  | 0.66 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  | 0.66 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001641.4 |  | 0.65 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  | 0.63 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0000357.5 |  | 0.63 | NRPS | cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val) | Penicillium rubens Wisconsin 54-1255
BGC0002135.2 |  | 0.63 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.42 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.88 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.41 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.76 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.50 out of 27.78
Confidence: medium
Additional weak hits (6):
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.88 out of 31.73
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.92 out of 26.06
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.35 out of 30.25
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 21.56 out of 31.73
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.99 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.38 out of 26.06
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 185850 - 211054:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Leu)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
LQ568_RS09045: Leu
Search NORINE for peptide: strict or relaxed
AMP-binding (469..867): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LHVSFDAFTFDAFALFGGEINCYGPTEGTVFATA
  Nearest Stachelhaus code(s):
    Leu DAFFLGCVFK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis