GCF_023524005.1 - 12 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP034414.1 (Bacillus safensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	NRPS	291,556	375,270	High	lichenysin	NRPS:Type I
Region 2	RRE-containing	821,302	842,207
Region 3	terpene,NI-siderophore	985,389	1,023,040	Medium	schizokinen	NRPS:Type IV
Region 4	betalactone	1,756,897	1,785,309	Medium	fengycin	NRPS:Type I
Region 5	terpene	1,860,208	1,882,082
Region 6	T3PKS	1,920,584	1,961,684
Region 7	terpene-precursor	2,128,736	2,149,626
Region 8	RiPP-like	2,268,876	2,279,202
Region 9	betalactone	2,419,189	2,451,641
Region 10	other	3,325,113	3,366,534	High	bacilysin	other:other
Region 11	lanthipeptide-class-ii	3,573,189	3,600,852	Medium	staphylococcin C55 α/staphylococcin C55 β	ribosomal:RiPP:Lanthipeptide
Region 12	NRP-metallophore,NRPS	3,612,611	3,664,340	High	bacillibactin/bacillibactin E/bacillibactin F	NRPS:Type I

NZ_CP034414.1 - Region 1 - NRPS

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Location: 291,556 - 375,270 nt. (total: 83,715 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: PPTase aminotransferase

EI692_RS01790: aminotransferase

smcogs: SMCOG1019: aminotransferase

EI692_RS01795: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: esterase

EI692_RS01780: thioesterase

smcogs: SMCOG1004: thioesterase

Ligases: ligase

EI692_RS01755: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

EI692_RS01760: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

EI692_RS01765: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

EI692_RS01770: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

EI692_RS01775: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Translocases: permease transporter

EI692_RS01735: sugar-binding lipoprotein

smcogs: SMCOG1143: sugar-binding lipoprotein

EI692_RS01850: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000381.5	0.76	NRPS	lichenysin	Bacillus licheniformis DSM 13 = ATCC 14580
BGC0001833.4	0.75	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	0.75	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001128.4	0.73	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.73	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002075.3	0.73	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001132.4	0.73	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001758.4	0.73	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002286.3	0.72	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.72	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000381.5	0.76	NRPS	lichenysin	Bacillus licheniformis DSM 13 = ATCC 14580
BGC0001833.4	0.75	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	0.75	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001128.4	0.73	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.73	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002075.3	0.73	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001132.4	0.73	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001758.4	0.73	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002286.3	0.72	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.72	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 16.87 out of 18.16

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.52 out of 29.72

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.49 out of 20.97

Confidence: medium

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.43 out of 32.93

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.25 out of 26.06

Confidence: medium

Additional weak hits (11):

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 21.73 out of 30.97

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.27 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.51 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.08 out of 26.06

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.46 out of 32.74

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.42 out of 28.14

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.25 out of 30.97

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.67 out of 36.53

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.83 out of 27.04

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.11 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.16 out of 26.06

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 291555 - 375270:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Glu - Leu - D-Leu) + (Ile - Asp - D-Leu) + (Ile) + (NH2 - D-Val) + (fatty_acid - Val)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

EI692_RS01755: Glu - Leu - Leu

Search NORINE for peptide: strict or relaxed

AMP-binding (463..868): Glu

nrpys: Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: gln (Gln)

Stachelhaus prediction details:

Stachelhaus sequence:: LALAFDASVKQADGLIGGEWNVYGPTETCVDAAV
Nearest Stachelhaus code(s):: Glu DAKDLGVVDK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1504..1902): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: TQSSFDAFMFDGMILFGGEVHMYGPSESTIFTTY
Nearest Stachelhaus code(s):: Leu DAFMLGMVFK (88% 8Å match)
Stachelhaus code match:: 90% (moderate)

AMP-binding (2541..2921): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: LWHAFDASIWEPFLLTGGDVNNYGPTENTVVATS
Nearest Stachelhaus code(s):: Leu DAWFLGNVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

EI692_RS01760: Ile - Asp - Leu

Search NORINE for peptide: strict or relaxed

AMP-binding (470..858): Ile

nrpys: Ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: ile (Ile)

Stachelhaus prediction details:

Stachelhaus sequence:: LSQGFDAITLETFLFTGGDLNVYGPTENTTISTF
Nearest Stachelhaus code(s):: Ile DAFFLGVTFK (68% 8Å match); Val DAYFWGVTFK (59% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (1496..1894): Asp

nrpys: Asp

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asp (Asp)

Stachelhaus prediction details:

Stachelhaus sequence:: YWLSYDLGYTSPKMVLGGEMNHYGPTETTIGTVT
Nearest Stachelhaus code(s):: Asp DLTKVGHIGK (82% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2536..2916): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: LWHAFDASIWEPFLLTGGDVNNYGPTENTVVATS
Nearest Stachelhaus code(s):: Leu DAWFLGNVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

EI692_RS01765: Ile

Search NORINE for peptide: strict or relaxed

AMP-binding (467..866): Ile

nrpys: Ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: ile (Ile)

Stachelhaus prediction details:

Stachelhaus sequence:: VNTSFDGFTFDGFILFGGEINVYGPTESTVFATY
Nearest Stachelhaus code(s):: Ile DGFFLGVVFK (88% 8Å match)
Stachelhaus code match:: 100% (strong)

EI692_RS01770: NH2 - Val

Search NORINE for peptide: strict or relaxed

CAL_domain (247..566): NH2

minowa: NH2

Prediction, score:

NH2: 10.3
Acetyl-CoA: 8.5
shikimic_acid: 0.0
AHBA: 0.0
fatty_acid: -0.4

AMP-binding (1789..2185): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: LETAFDAFTYEGFLLVGGDLNGYGPTENTTFSCV
Nearest Stachelhaus code(s):: Val DAYFLGGTFK (65% 8Å match)
Stachelhaus code match:: 100% (strong)

EI692_RS01775: fatty_acid - Val

Search NORINE for peptide: strict or relaxed

CAL_domain (226..668): fatty_acid

minowa: fatty_acid

Prediction, score:

fatty_acid: 21.8
Acetyl-CoA: 9.4
AHBA: 8.5
shikimic_acid: 0.0
NH2: 0.0

AMP-binding (1874..2272): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LETSFDAFTFEGCLLVGGEVNAYGPTENTTLATT
Nearest Stachelhaus code(s):: Val DAFWLGATFK (71% 8Å match)
Stachelhaus code match:: 80% (moderate)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CRP	Cyclic AMP receptor protein
CcpA	Catabolite control protein A
LexA variant 3	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
NtrC	Nitrogen regulatory protein C
ToxT	Regulator of MSHA biosynthesis

NZ_CP034414.1 - Region 2 - RRE-containing

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Location: 821,302 - 842,207 nt. (total: 20,906 nt) Show pHMM detection rules used

RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

EI692_RS04235: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

Transferases: sulfhydrylase

EI692_RS04210: O-succinylhomoserine sulfhydrylase

smcogs: SMCOG1168: O-succinylhomoserine sulfhydrylase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002285.2	0.39	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0002447.3	0.39	ribosomal	cerecyclin	Bacillus cereus
BGC0000600.3	0.39	ribosomal	thurincin H	Bacillus thuringiensis
BGC0001684.3	0.37	other (other)	N-acyloxyacyl glutamine	Klebsiella variicola
BGC0002663.2	0.36	ribosomal	amyloliquecidin GF610	Bacillus amyloliquefaciens UMAF6639
BGC0002470.2	0.36	other (other)	synechobactin C9, synechobactin C11, synechobactin 13, synechobactin 14, synechobactin 16, synechobactin A, synechobactin B, synechobactin C	Synechococcus sp. PCC 7002
BGC0000498.5	0.35	ribosomal	bovicin HJ50	Streptococcus equinus
BGC0000561.5	0.35	ribosomal	thermophilin 1277	Streptococcus thermophilus
BGC0000815.4	0.35	other (other)	loline, N-acetylnorloline, N-formylloline	Epichloe uncinata
BGC0001606.3	0.35	PKS	gibepyrone-A	Fusarium fujikuroi IMI 58289

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002285.2	0.39	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0002447.3	0.39	ribosomal	cerecyclin	Bacillus cereus
BGC0000600.3	0.39	ribosomal	thurincin H	Bacillus thuringiensis
BGC0001684.3	0.37	other (other)	N-acyloxyacyl glutamine	Klebsiella variicola
BGC0002663.2	0.36	ribosomal	amyloliquecidin GF610	Bacillus amyloliquefaciens UMAF6639
BGC0002470.2	0.36	other (other)	synechobactin C9, synechobactin C11, synechobactin 13, synechobactin 14, synechobactin 16, synechobactin A, synechobactin B, synechobactin C	Synechococcus sp. PCC 7002
BGC0000498.5	0.35	ribosomal	bovicin HJ50	Streptococcus equinus
BGC0000561.5	0.35	ribosomal	thermophilin 1277	Streptococcus thermophilus
BGC0000815.4	0.35	other (other)	loline, N-acetylnorloline, N-formylloline	Epichloe uncinata
BGC0001606.3	0.35	PKS	gibepyrone-A	Fusarium fujikuroi IMI 58289

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.49 out of 24.78

Confidence: medium

Additional weak hits (2):

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.80 out of 32.74

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 23.11 out of 29.65

Confidence: weak

RREFinder

TFBS Finder

RRE predictions

: RRE type: PqqD_RRE; Location: 36 - 92; Score: 35.6

TFBS definitions

Regulator	Description
LexA variant 2	Repressor of DNA damage response

NZ_CP034414.1 - Region 3 - NI-siderophore,terpene

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Location: 985,389 - 1,023,040 nt. (total: 37,652 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)
NI-siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

EI692_RS05045: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

EI692_RS05050: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

EI692_RS05110: lysine/ornithine N-monooxygenase

smcogs: SMCOG1080: lysine/ornithine N-monooxygenase

Transferases: acetyltransferase aminotransferase

EI692_RS05070: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

EI692_RS05090: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Hydrolases: hydrolase

EI692_RS05040: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Lyases: decarboxylase

EI692_RS05095: Decarboxylase, pyridoxal-dependent

smcogs: SMCOG1180: Decarboxylase, pyridoxal-dependent

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000647.3	0.91	terpene	carotenoid	Rhodobacter sphaeroides
BGC0002633.2	0.60	other (other)	schizokinen	Leptolyngbya sp. PCC 7376
BGC0002469.2	0.55	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0002683.2	0.55	NRPS	schizokinen	Nostoc sp. PCC 7120 = FACHB-418
BGC0001572.3	0.50	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0000645.3	0.50	terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0001478.5	0.48	other (other)	desferrioxamine E	Streptomyces sp. ID38640
BGC0002692.2	0.46	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0000941.3	0.46	other (other)	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002305.2	0.45	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000647.3	0.76	terpene	carotenoid	Rhodobacter sphaeroides
BGC0002469.2	0.67	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0002633.2	0.66	other (other)	schizokinen	Leptolyngbya sp. PCC 7376
BGC0002683.2	0.64	NRPS	schizokinen	Nostoc sp. PCC 7120 = FACHB-418
BGC0001572.3	0.62	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0001478.5	0.61	other (other)	desferrioxamine E	Streptomyces sp. ID38640
BGC0002692.2	0.60	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0000941.3	0.60	other (other)	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001531.5	0.59	other (other)	bisucaberin B	Tenacibaculum mesophilum
BGC0002305.2	0.59	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	C30 carotenoid	diapophytoene	C30	acyclic	none

Genes with terpene domains:

EI692_RS05055: PT_phytoene_like

Domain 1 (5 - 278): Prenyltransferase; Phytoene synthase like

Subtype: Diapophytoene synthase

Reactions:: FPP → diapophytoene

Transcription Factor Binding Sites

Binding sites found:

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 24.36 out of 29.25

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.33 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.42 out of 29.38

Confidence: medium

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.53 out of 25.88

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.47 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.18 out of 28.19

Confidence: medium

Additional weak hits (6):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.77 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.41 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.44 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.93 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.46 out of 29.38

Confidence: weak

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 20.93 out of 29.72

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate

TFBS definitions

Regulator	Description
FuR variant 1	Ferric Uptake Regulator
PsrA	Oleic acid responsive regulator
SypG	Regulator of biofilm formation and host colonization
ZuR variant 1	Zinc-responsive repressor

NZ_CP034414.1 - Region 4 - betalactone

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Location: 1,756,897 - 1,785,309 nt. (total: 28,413 nt) Show pHMM detection rules used

betalactone: (HMGL-like and AMP-binding)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

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SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

EI692_RS08995: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

EI692_RS09050: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Transferases: carboxylase transferase

EI692_RS09020: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

EI692_RS09040: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Lyases: hydratase

EI692_RS09025: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase

EI692_RS09015: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

EI692_RS09030: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

EI692_RS09045: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001135.5	0.55	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001268.4	0.54	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0002284.3	0.52	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0001160.5	0.52	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.52	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001103.5	0.50	NRPS, PKS	mycosubtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000706.3	0.45	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0002405.2	0.45	saccharide	mid-chain acyl sugars	Solanum lycopersicum
BGC0001095.5	0.44	NRPS	fengycin	Bacillus velezensis FZB42
BGC0002020.3	0.44	NRPS, saccharide	photolose, oligosaccharide 1 (GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 2 (GlcNAc-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 3 (GlcNAc-β(1-4)-GlcNAc-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 4 (GlcN-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 5 (6-phosphoGlcN-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc)	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001135.5	0.55	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001268.4	0.54	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0002284.3	0.52	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0001160.5	0.52	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.52	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001103.5	0.50	NRPS, PKS	mycosubtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000706.3	0.45	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0002405.2	0.45	saccharide	mid-chain acyl sugars	Solanum lycopersicum
BGC0001095.5	0.44	NRPS	fengycin	Bacillus velezensis FZB42
BGC0002020.3	0.44	NRPS, saccharide	photolose, oligosaccharide 1 (GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 2 (GlcNAc-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 3 (GlcNAc-β(1-4)-GlcNAc-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 4 (GlcN-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 5 (6-phosphoGlcN-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc)	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.12 out of 20.97

Confidence: strong

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 22.38 out of 26.33

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.69 out of 27.78

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.68 out of 27.55

Confidence: medium

Additional weak hits (2):

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.70 out of 29.25

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 19.16 out of 30.12

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM	Regulator of nitrogen-fixation genes

NZ_CP034414.1 - Region 5 - terpene

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Location: 1,860,208 - 1,882,082 nt. (total: 21,875 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

EI692_RS09445: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002173.2	0.46	saccharide, terpene	fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol	Aspergillus fumigatus A1163
BGC0001535.3	0.42	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0000313.4	0.36	NRPS	beauvericin	Beauveria bassiana
BGC0000670.4	0.34	terpene	thalianol, thaliandiol, thalianin	Arabidopsis thaliana
BGC0002255.3	0.33	PKS	lijiquinone	Ascomycota sp. F53
BGC0001575.4	0.31	NRPS	PZN5, PZN6, PZN7, PZN9, PZN10, PZN11	Ruminococcus sp. 5_1_39BFAA
BGC0001865.4	0.30	PKS	elsinochrome C	Parastagonospora nodorum SN15
BGC0000663.5	0.30	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0000154.4	0.28	PKS	stipitatic acid	Talaromyces stipitatus ATCC 10500
BGC0001739.3	0.28	other (other)	phosphonoacetic Acid	Streptomyces sp. NRRL F-525

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002173.2	0.46	saccharide, terpene	fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol	Aspergillus fumigatus A1163
BGC0001535.3	0.42	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0000313.4	0.36	NRPS	beauvericin	Beauveria bassiana
BGC0000670.4	0.34	terpene	thalianol, thaliandiol, thalianin	Arabidopsis thaliana
BGC0002255.3	0.33	PKS	lijiquinone	Ascomycota sp. F53
BGC0001575.4	0.31	NRPS	PZN5, PZN6, PZN7, PZN9, PZN10, PZN11	Ruminococcus sp. 5_1_39BFAA
BGC0001865.4	0.30	PKS	elsinochrome C	Parastagonospora nodorum SN15
BGC0000663.5	0.30	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0000154.4	0.28	PKS	stipitatic acid	Talaromyces stipitatus ATCC 10500
BGC0001739.3	0.28	other (other)	phosphonoacetic Acid	Streptomyces sp. NRRL F-525

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	hopanoid		C30	hopanoid skeleton	unknown
triterpene	polypodane		C30	polypodane skeleton	unknown

Genes with terpene domains:

EI692_RS09450: T2TS

Domain 1 (8 - 620): Type 2 terpene synthase

Subtype: Squalene substrate

Reactions:: squalene → hopanoid; squalene → polypodane

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.12 out of 20.97

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.53 out of 26.06

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 26.67 out of 27.78

Confidence: strong

Additional weak hits (3):

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 22.66 out of 26.12

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.41 out of 25.75

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.89 out of 30.25

Confidence: weak

Terpene

TFBS Finder

Glossary

No acronyms to display

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis

NZ_CP034414.1 - Region 6 - T3PKS

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Location: 1,920,584 - 1,961,684 nt. (total: 41,101 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

EI692_RS09920: NADH:flavin oxidoreductase/NADH oxidase

smcogs: SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

Transferases: methyltransferase

EI692_RS09845: isoprenylcysteine carboxyl methyltransferase

smcogs: SMCOG1150: isoprenylcysteine carboxyl methyltransferase

Hydrolases: deacetylase

EI692_RS09855: polysaccharide deacetylase

smcogs: SMCOG1235: polysaccharide deacetylase

Ligases: synthase

EI692_RS09850: chalcone and stilbene synthase domain protein

smcogs: SMCOG1024: chalcone and stilbene synthase domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001831.3	0.51	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001310.5	0.49	PKS	naringenin	Streptomyces clavuligerus ATCC 27064
BGC0000282.3	0.49	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002127.3	0.47	PKS	flaviolin, 1,3,6,8-tetrahydroxynaphthalene	Streptomyces coelicolor A3(2)
BGC0001962.3	0.45	PKS	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0001475.4	0.42	terpene	aspterric acid	Aspergillus terreus NIH2624
BGC0002332.2	0.42	PKS	4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A	Candidatus Entotheonella sp.
BGC0001267.3	0.36	terpene	elymoclavine, Agroclavine I	Claviceps fusiformis
BGC0000348.4	0.36	NRPS	ergovaline	Epichloe festucae var. lolii
BGC0001304.3	0.35	PKS	aflavarin	Aspergillus flavus NRRL3357

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001831.3	0.51	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001310.5	0.49	PKS	naringenin	Streptomyces clavuligerus ATCC 27064
BGC0000282.3	0.49	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002127.3	0.47	PKS	flaviolin, 1,3,6,8-tetrahydroxynaphthalene	Streptomyces coelicolor A3(2)
BGC0001962.3	0.45	PKS	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0001475.4	0.42	terpene	aspterric acid	Aspergillus terreus NIH2624
BGC0002332.2	0.42	PKS	4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A	Candidatus Entotheonella sp.
BGC0001267.3	0.36	terpene	elymoclavine, Agroclavine I	Claviceps fusiformis
BGC0000348.4	0.36	NRPS	ergovaline	Epichloe festucae var. lolii
BGC0001304.3	0.35	PKS	aflavarin	Aspergillus flavus NRRL3357

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.37 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.42 out of 26.06

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 27.15 out of 29.38

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.98 out of 20.97

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.55 out of 27.78

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.39 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.91 out of 29.38

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.98 out of 20.97

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.46 out of 30.25

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.73 out of 28.19

Confidence: strong

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 21.29 out of 27.04

Confidence: medium

Additional weak hits (8):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.99 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.80 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 26.16 out of 32.74

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.52 out of 32.74

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 23.15 out of 30.22

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.34 out of 32.93

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.13 out of 25.75

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.01 out of 24.78

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
DasR	N-acetylglucosamine dependent repressor
FuR variant 1	Ferric Uptake Regulator
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_CP034414.1 - Region 7 - terpene-precursor

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Location: 2,128,736 - 2,149,626 nt. (total: 20,891 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: carboxylase

EI692_RS10955: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase

EI692_RS10920: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

EI692_RS10925: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0000638.3	0.37	terpene	carotenoid	Pantoea ananatis
BGC0000640.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC404

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0000638.3	0.37	terpene	carotenoid	Pantoea ananatis
BGC0000640.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC404

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

EI692_RS10925: PT_FPPS_like

Domain 1 (33 - 296): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: IPP, DMAPP → FPP

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.38 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.88 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.42 out of 27.78

Confidence: medium

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 22.67 out of 26.33

Confidence: medium

Additional weak hits (1):

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.47 out of 36.54

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis

NZ_CP034414.1 - Region 8 - RiPP-like

Download region GenBank file

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Location: 2,268,876 - 2,279,202 nt. (total: 10,327 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: deacetylase

EI692_RS11710: polysaccharide deacetylase

smcogs: SMCOG1235: polysaccharide deacetylase

Similar gene clusters

Analysis type:

Reference	RiPP-like	Similarity score	Type	Compound(s)	Organism
BGC0000489.3		0.59	ribosomal	enterocin AS-48	Enterococcus faecalis

Reference	Aggregated	Similarity score	Type	Compound(s)	Organism
BGC0000489.3		0.59	ribosomal	enterocin AS-48	Enterococcus faecalis

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.28 out of 26.06

Confidence: medium

Additional weak hits (2):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 26.19 out of 31.73

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.81 out of 39.62

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
MogR	Repressor of flagellar motility genes

NZ_CP034414.1 - Region 9 - betalactone

Download region GenBank file

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Location: 2,419,189 - 2,451,641 nt. (total: 32,453 nt) Show pHMM detection rules used

betalactone: (HMGL-like and AMP-binding)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidase

EI692_RS12555: pyruvate oxidase/decarboxylase

smcogs: SMCOG1055: pyruvate oxidase/decarboxylase

EI692_RS12610: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Ligases: ligase synthase

EI692_RS12540: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

EI692_RS12590: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002174.2	0.60	NRPS	ε-Poly-L-lysine	Epichloe festucae
BGC0001261.3	0.60	NRPS	AM-toxin	Alternaria alternata
BGC0000357.5	0.59	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001240.4	0.59	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0002164.2	0.58	NRPS	peramine	Epichloe festucae
BGC0002276.2	0.57	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001268.4	0.55	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0002518.3	0.45	NRPS	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0001441.5	0.44	other (other)	belactosin A, belactosin C	Streptomyces sp.
BGC0000308.5	0.43	NRPS	aureusimine A, aureusimine B, aureusimine C	Staphylococcus aureus subsp. aureus str. JKD6008

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002174.2	0.60	NRPS	ε-Poly-L-lysine	Epichloe festucae
BGC0001261.3	0.60	NRPS	AM-toxin	Alternaria alternata
BGC0000357.5	0.59	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001240.4	0.59	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0002164.2	0.58	NRPS	peramine	Epichloe festucae
BGC0002276.2	0.57	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001268.4	0.55	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0002518.3	0.45	NRPS	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0001441.5	0.44	other (other)	belactosin A, belactosin C	Streptomyces sp.
BGC0000308.5	0.43	NRPS	aureusimine A, aureusimine B, aureusimine C	Staphylococcus aureus subsp. aureus str. JKD6008

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.06 out of 27.78

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.85 out of 20.97

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.30 out of 25.31

Confidence: medium

Additional weak hits (5):

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 26.54 out of 36.54

Confidence: weak

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 20.93 out of 29.72

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.50 out of 31.73

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.57 out of 32.74

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
CatR	H2O2-responsive repressor
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ToxT	Regulator of MSHA biosynthesis

NZ_CP034414.1 - Region 10 - other

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Location: 3,325,113 - 3,366,534 nt. (total: 41,422 nt) Show pHMM detection rules used

other: (Neocarzinostat or bcpB or frbD or mitE or prnB or CaiA or bacilysin or orf2_PTase)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

EI692_RS17210: 3-hydroxyisobutyrate dehydrogenase

smcogs: SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

EI692_RS17260: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

EI692_RS17275: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

EI692_RS17365: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

Transferases: aminotransferase transferase

EI692_RS17270: aminotransferase

smcogs: SMCOG1019: aminotransferase

EI692_RS17295: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

EI692_RS17320: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

Lyases: dehydratase lyase

EI692_RS17265: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

EI692_RS17285: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

EI692_RS17290: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000888.5	0.77	other (other)	bacilysin	Bacillus sp. CS93
BGC0001184.4	0.72	other (other)	bacilysin	Bacillus velezensis FZB42
BGC0000898.5	0.56	saccharide	desosamine, pikromycin, neomethymycin, narbomycin	Streptomyces venezuelae
BGC0000791.3	0.56	saccharide	O-antigen	Cronobacter sakazakii
BGC0000790.3	0.55	saccharide	O-antigen	Escherichia coli
BGC0000794.5	0.55	saccharide	S-layer glycan	Geobacillus stearothermophilus
BGC0000773.3	0.55	saccharide	lipopolysaccharide	Escherichia coli
BGC0000766.3	0.52	saccharide	exopolysaccharide	Lactobacillus johnsonii
BGC0000792.3	0.52	saccharide	polysaccharide	Enterococcus faecalis OG1RF
BGC0001817.5	0.52	other (other)	vancosamine	Streptomyces sp. WAC2288

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000888.5	0.77	other (other)	bacilysin	Bacillus sp. CS93
BGC0001184.4	0.72	other (other)	bacilysin	Bacillus velezensis FZB42
BGC0000898.5	0.56	saccharide	desosamine, pikromycin, neomethymycin, narbomycin	Streptomyces venezuelae
BGC0000791.3	0.56	saccharide	O-antigen	Cronobacter sakazakii
BGC0000790.3	0.55	saccharide	O-antigen	Escherichia coli
BGC0000794.5	0.55	saccharide	S-layer glycan	Geobacillus stearothermophilus
BGC0000773.3	0.55	saccharide	lipopolysaccharide	Escherichia coli
BGC0000766.3	0.52	saccharide	exopolysaccharide	Lactobacillus johnsonii
BGC0000792.3	0.52	saccharide	polysaccharide	Enterococcus faecalis OG1RF
BGC0001817.5	0.52	other (other)	vancosamine	Streptomyces sp. WAC2288

Similar known clusters from MIBiG 4.0

Similar subclusters

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.53 out of 26.06

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.26 out of 26.06

Confidence: strong

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.58 out of 21.84

Confidence: medium

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 18.33 out of 19.52

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.39 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.64 out of 26.06

Confidence: medium

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.38 out of 25.88

Confidence: medium

Additional weak hits (1):

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MexT	Global virulence regulator
MogR	Repressor of flagellar motility genes
PsrA	Oleic acid responsive regulator

NZ_CP034414.1 - Region 11 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 3,573,189 - 3,600,852 nt. (total: 27,664 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

EI692_RS18415: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: phosphotransferase

EI692_RS18385: Glucose-specific phosphotransferase enzyme IIA

smcogs: SMCOG1145: Glucose-specific phosphotransferase enzyme IIA

Hydrolases: hydrolase

EI692_RS18465: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

Lyases: cyclase

EI692_RS18420: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

EI692_RS18430: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000520.5	0.78	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0000555.3	0.72	ribosomal	staphylococcin C55 α, staphylococcin C55 β	Staphylococcus aureus
BGC0001229.4	0.63	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0002110.3	0.61	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0001391.3	0.55	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000517.4	0.51	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0001311.5	0.51	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0002663.2	0.51	ribosomal	amyloliquecidin GF610	Bacillus amyloliquefaciens UMAF6639
BGC0002005.2	0.50	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0000552.3	0.50	ribosomal	SmbA, SmbB	Streptococcus mutans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000520.5	0.78	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0000555.3	0.72	ribosomal	staphylococcin C55 α, staphylococcin C55 β	Staphylococcus aureus
BGC0001229.4	0.63	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0002110.3	0.61	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0001391.3	0.55	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000517.4	0.51	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0001311.5	0.51	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0002663.2	0.51	ribosomal	amyloliquecidin GF610	Bacillus amyloliquefaciens UMAF6639
BGC0002005.2	0.50	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0000552.3	0.50	ribosomal	SmbA, SmbB	Streptococcus mutans

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for EI692_RS18420

EI692_RS18435

Leader:

MNDKNSKAKNGLNNELELGKYLESDMIALTDDDVAGG

Core:

VTPAISILVSGFISTNTCPSTACTRAC

Core with dehydrations:

VDhbPAIDhaILVDhaGFIDhaDhbNDhbCysPDhaDhbACysDhbRACys

antiSMASH-DB 4.0 matches for EI692_RS18435

100.0%

NZ_CP034414.1and 1 other:

NZ_CP034414.1 Lanthipeptides: EI692_RS18435_lanthipeptide

Lanthipeptides: EI692_RS18435_lanthipeptide

1

VTPAISILVSGFISTNTCPSTACTRAC

27

VTPAISILVSGFISTNTCPSTACTRAC

1

VTPAISILVSGFISTNTCPSTACTRAC

27

67.9%

NZ_CP061868.1and 1 other:

NZ_CP061868.1 Lanthipeptides: IE339_RS06335_lanthipeptide

Lanthipeptides: IE339_RS06335_lanthipeptide

1

VTPAISIL-VSGFISTNTCPSTACTRAC

27

+TP I I V+G+ISTNTCP+T+CTRAC

1

ITPTIVITAVTGYISTNTCPTTSCTRAC

28

66.7%

NZ_CP016767.1and 3 others:

NZ_CP016767.1 Lanthipeptides: BCV50_RS13415_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptide

Lanthipeptides: BCV50_RS13415_lanthipeptide

2

TPAISILVSGFISTNTCPSTACTRAC

27

TPA+S+ ++G+IS+NTCP+TACTRAC

2

TPALSV-ITGYISSNTCPTTACTRAC

26

with 74 more sequence matches

Only the first 10 are displayed here.

66.7%

NZ_JALAPU010000003.1and 7 others:

NZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07925_lanthipeptideNZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00585_lanthipeptideNZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00585_lanthipeptideNZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17010_lanthipeptideNZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17010_lanthipeptideNZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04640_lanthipeptideNZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04640_lanthipeptide

Lanthipeptides: MOD17_RS07925_lanthipeptide

2

TPAISILVSGFISTNTCPSTACTRAC

27

TPA+S+ V+ +IS+NTCP+TACTRAC

2

TPALSV-VTAYISSNTCPTTACTRAC

26

66.7%

NZ_NUIO01000031.1and 1 other:

NZ_NUIO01000031.1 Lanthipeptides: CN977_RS23165_lanthipeptide

Lanthipeptides: CN977_RS23165_lanthipeptide

1

VTPAISIL---VSGFISTNTCPSTACTRAC

27

+TP +SI VSG+IS+NTCP+TACTRAC

1

ITPTVSIALTAVSGYISSNTCPTTACTRAC

30

60.7%

NZ_PCGR01000003.1and 1 other:

NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09625_lanthipeptide

Lanthipeptides: CQS04_RS09625_lanthipeptide

2

TPAISI-LVSGFISTNTCPSTACTRAC

27

TP I I ++G+IS N+CP+TACTRAC

2

TPTIVITAITGYISANSCPTTACTRAC

28

60.0%

NZ_QGEE01000020.1and 3 others:

NZ_QGEE01000020.1 Lanthipeptides: DKP74_RS06165_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05385_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05385_lanthipeptide

Lanthipeptides: DKP74_RS06165_lanthipeptide

2

TPAI---SILVSGFISTNTCPSTACTRAC

27

TP I +++VSGF+S++TCP+TACTRAC

2

TPVIGYSAVIVSGFVSSHTCPTTACTRAC

30

59.3%

NZ_KE384533.1and 2 others:

NZ_KE384533.1 Lanthipeptides: K329_RS31315_lanthipeptideNZ_KE384533.1 Lanthipeptides: K329_RS31315_lanthipeptide

Lanthipeptides: K329_RS31315_lanthipeptide

2

TPAISI-LVSGFISTNTCPSTACTRAC

27

TP I I +VS ++STNTCP+T+CT C

1

TPTIVISVVSAYVSTNTCPTTSCTDEC

27

54.8%

NZ_AP026714.1and 21 others:

NZ_AP026714.1 Lanthipeptides: PO853_RS06520_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11270_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11270_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03990_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03990_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09815_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09815_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00090_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00090_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07695_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07695_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03740_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03740_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00125_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00125_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07745_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07745_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04680_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04680_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07985_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07985_lanthipeptide

Lanthipeptides: PO853_RS06520_lanthipeptide

1

VTPAISILVSGFISTNTCPSTACTRAC

27

+T ISI VSG+IS TCP++ CTRAC

5

ITIPISIAVSGWISDKTCPTSVCTRAC

31

53.6%

NZ_CP051884.1and 3 others:

NZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptide

Lanthipeptides: HGK68_RS15130_lanthipeptide

8

LVSGFISTNTCPSTACTRAC

27

+VS +IS NTCPS+ACTRAC

9

IVSAWISNNTCPSSACTRAC

28

51.5%

NZ_MIFN01000022.1and 1 other:

NZ_MIFN01000022.1 Lanthipeptides: BHL26_RS15355_lanthipeptide

Lanthipeptides: BHL26_RS15355_lanthipeptide

9

VSGFISTNTCPSTACTRAC

27

VSG+IS+NTCPSTACTRAC

15

VSGYISSNTCPSTACTRAC

33

50.0%

NZ_CACZYW010000004.1and 3 others:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide

Lanthipeptides: HUF10_RS02820_lanthipeptide

2

TPAISILV--SGFISTNTCPSTACTRAC

27

TPA ++V S ++S TCP+TACTRAC

5

TPATPVIVAVSAYVSDKTCPTTACTRAC

32

46.2%

NZ_BLIS01000009.1and 5 others:

NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04825_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptide

Lanthipeptides: GVO03_RS04825_lanthipeptide

2

TPAIS---ILVSGFISTNTCPSTACTRAC

27

TPAI I V+ F+S NTCP++ACTRAC

11

TPAIGKGVIAVTAFVSANTCPTSACTRAC

39

MIBiG 4.0 matches for EI692_RS18435

27.0%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

4

AISILVSGFISTNTCPSTACTRAC

27

AI V+ +S CP+T CT C

14

AIQAGVAVGVSAAFCPTTKCTSRC

37

22.2%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

18

CPSTACTRAC

27

CP+T CT C

17

CPTTKCTSKC

26

EI692_RS18440

Leader:

MKNEVNKLQKEEQVTWFEEIVDQEFDDDVFGA

Core:

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

Core with dehydrations:

CysDhaDhbNDhbFDhaLDhaDYWGNKGGWCysDhbIDhaHECysMDhaWCysK

antiSMASH-DB 4.0 matches for EI692_RS18440

100.0%

NZ_CP034414.1and 1 other:

NZ_CP034414.1 Lanthipeptides: EI692_RS18440_lanthipeptide

Lanthipeptides: EI692_RS18440_lanthipeptide

1

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

30

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

1

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

30

90.0%

NZ_CP061868.1and 1 other:

NZ_CP061868.1 Lanthipeptides: IE339_RS06330_lanthipeptide

Lanthipeptides: IE339_RS06330_lanthipeptide

1

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

30

C+TNTFSLSDYWGNKGGWCT +HECMSWCK

1

CTTNTFSLSDYWGNKGGWCTATHECMSWCK

30

90.0%

NZ_FMPI01000012.1and 1 other:

NZ_FMPI01000012.1 Lanthipeptides: BJR39_RS08305_lanthipeptide

Lanthipeptides: BJR39_RS08305_lanthipeptide

1

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

30

CSTNTFSLSDYWGN G WCT SHECMSWCK

1

CSTNTFSLSDYWGNNGNWCTASHECMSWCK

30

with 101 more sequence matches

Only the first 10 are displayed here.

86.7%

NZ_CACZYW010000004.1and 1 other:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02825_lanthipeptide

Lanthipeptides: HUF10_RS02825_lanthipeptide

1

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

30

CSTNTFSLSDYWGN G WCT+SHECM+WCK

1

CSTNTFSLSDYWGNNGNWCTLSHECMAWCK

30

86.7%

NZ_CP027862.1and 1 other:

NZ_CP027862.1 Lanthipeptides: allorf_0097945_0098112_lanthipeptide

Lanthipeptides: allorf_0097945_0098112_lanthipeptide

1

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

30

CSTNTFSLSDYWGN+G WCT++HECMSWCK

1

CSTNTFSLSDYWGNRGYWCTLTHECMSWCK

30

86.7%

NZ_CP051884.1and 2 others:

NZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptide

Lanthipeptides: HGK68_RS15125_lanthipeptide

1

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

30

CSTNTFSLSDYWGN G CTI+HECMSWCK

1

CSTNTFSLSDYWGNNGWLCTITHECMSWCK

30

86.7%

NZ_FNHR01000005.1and 1 other:

NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05590_lanthipeptide

Lanthipeptides: BLQ37_RS05590_lanthipeptide

1

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

30

CSTNTFSLSDY GN G WCTISHECM+WCK

1

CSTNTFSLSDYMGNNGNWCTISHECMAWCK

30

86.7%

NZ_QGEE01000020.1and 5 others:

NZ_QGEE01000020.1 Lanthipeptides: DKP74_RS06160_lanthipeptideNZ_QGEF01000018.1 Lanthipeptides: DKP75_RS05595_lanthipeptideNZ_QGEF01000018.1 Lanthipeptides: DKP75_RS05595_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05380_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05380_lanthipeptide

Lanthipeptides: DKP74_RS06160_lanthipeptide

1

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

30

CSTNTFSLSDYWGN+G WCT+SHECM+WCK

1

CSTNTFSLSDYWGNRGNWCTLSHECMAWCK

30

83.3%

NZ_AP026714.1and 21 others:

NZ_AP026714.1 Lanthipeptides: PO853_RS06515_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11265_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11265_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03985_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03985_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09810_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09810_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00085_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00085_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07700_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07700_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03735_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03735_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00120_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00120_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07750_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07750_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04675_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04675_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07990_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07990_lanthipeptide

Lanthipeptides: PO853_RS06515_lanthipeptide

1

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

30

C+TNTFSLSDYWGNKG WCT +HECM WCK

1

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

30

83.3%

NZ_BLIS01000009.1and 7 others:

NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04820_lanthipeptideNZ_LR134317.1 Lanthipeptides: EL136_RS01685_lanthipeptideNZ_LR134317.1 Lanthipeptides: EL136_RS01685_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02620_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02620_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01935_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01935_lanthipeptide

Lanthipeptides: GVO03_RS04820_lanthipeptide

1

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

30

C+TNTFSLSDYWGNKG WCT++HECM+WCK

1

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

30

83.3%

NZ_CP016767.1and 11 others:

NZ_CP016767.1 Lanthipeptides: BCV50_RS13410_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15325_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15325_lanthipeptideNZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07920_lanthipeptideNZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07920_lanthipeptideNZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00580_lanthipeptideNZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00580_lanthipeptideNZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17015_lanthipeptideNZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17015_lanthipeptideNZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04645_lanthipeptideNZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04645_lanthipeptide

Lanthipeptides: BCV50_RS13410_lanthipeptide

1

CSTNTFSLSDYWGNKGGWCTISHECMSWC

29

C+TNTFSLSDYWGNKGGWCT+S ECM+WC

1

CTTNTFSLSDYWGNKGGWCTVSKECMAWC

29

83.3%

NZ_MIFN01000022.1and 1 other:

NZ_MIFN01000022.1 Lanthipeptides: BHL26_RS15350_lanthipeptide

Lanthipeptides: BHL26_RS15350_lanthipeptide

1

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

30

C+TNTFSLSDYWGN G WC++SHECMSWCK

1

CTTNTFSLSDYWGNDGSWCSLSHECMSWCK

30

83.3%

NZ_PCGR01000003.1and 1 other:

NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09620_lanthipeptide

Lanthipeptides: CQS04_RS09620_lanthipeptide

1

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

30

C+TNTFSLSDYWGN G WCT +HECMSWCK

1

CTTNTFSLSDYWGNNGNWCTATHECMSWCK

30

MIBiG 4.0 matches for EI692_RS18440

60.0%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

1

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

30

C+TNTFSLS+ GN GGWCT++ EC C

1

CTTNTFSLSNALGNNGGWCTLTKECQPNCN

30

36.7%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

6

FSLSDYWGNKGGWCTISHECMSWC

29

+++S GNKG +CT++ ECM C

4

YNISCRLGNKGAYCTLTVECMPSC

27

15.4%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

19

CTISHECMSWC

29

CT+S EC C

28

CTLSKECQPNC

38

allorf_3594412_3594594

Leader:

MTSAHQRLKNRSYG

Core:

ISITGEFSISQRKSYIVLPRRDRKAPLCRISMLHRITNFYIVCTCF

Core with dehydrations:

IDhaIDhbGEFDhaIDhaQRKDhaYIVLPRRDRKAPLCysRIDhaMLHRIDhbNFYIVCysDhbCysF

antiSMASH-DB 4.0 matches for allorf_3594412_3594594

100.0%

NZ_CP034414.1:

Lanthipeptides: allorf_3594412_3594594_lanthipeptide

1

ISITGEFSISQRKSYIVLPRRDRKAPLCRISMLHRITNFYIVCTCF

46

ISITGEFSISQRKSYIVLPRRDRKAPLCRISMLHRITNFYIVCTCF

1

ISITGEFSISQRKSYIVLPRRDRKAPLCRISMLHRITNFYIVCTCF

46

19.6%

NZ_CP010833.1and 2 others:

NZ_CP013738.1 Lanthipeptides: allorf_2656180_2656281_lanthipeptideNZ_LIXK01000002.1 Lanthipeptides: allorf_0351346_0351447_lanthipeptide

Lanthipeptides: allorf_5390411_5390512_lanthipeptide

25

APLCRISMLHRITN

38

APL R S+LHR T+

2

APLLRCSLLHRGTD

15

12.1%

NZ_CP114039.1:

Lanthipeptides: allorf_7147535_7147768_lanthipeptide

24

KAPLCRISMLHRITNFYIVCT

44

KA LCR+++L + CT

5

KASLCRVAVLLSGALSWSACT

25

MIBiG 4.0 matches for allorf_3594412_3594594

6.5%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

26

PLCRISML

33

P C+ L

9

PGCKTGAL

16

Lanthipeptide(s) for EI692_RS18430

EI692_RS18435

Leader:

MNDKNSKAKNGLNNELELGKYLESDMIALTDDDVAGG

Core:

VTPAISILVSGFISTNTCPSTACTRAC

Core with dehydrations:

VDhbPAIDhaILVDhaGFIDhaDhbNDhbCysPDhaDhbACysDhbRACys

antiSMASH-DB 4.0 matches for EI692_RS18435

100.0%

NZ_CP034414.1and 1 other:

NZ_CP034414.1 Lanthipeptides: EI692_RS18435_lanthipeptide

Lanthipeptides: EI692_RS18435_lanthipeptide

1

VTPAISILVSGFISTNTCPSTACTRAC

27

VTPAISILVSGFISTNTCPSTACTRAC

1

VTPAISILVSGFISTNTCPSTACTRAC

27

67.9%

NZ_CP061868.1and 1 other:

NZ_CP061868.1 Lanthipeptides: IE339_RS06335_lanthipeptide

Lanthipeptides: IE339_RS06335_lanthipeptide

1

VTPAISIL-VSGFISTNTCPSTACTRAC

27

+TP I I V+G+ISTNTCP+T+CTRAC

1

ITPTIVITAVTGYISTNTCPTTSCTRAC

28

66.7%

NZ_CP016767.1and 3 others:

NZ_CP016767.1 Lanthipeptides: BCV50_RS13415_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptide

Lanthipeptides: BCV50_RS13415_lanthipeptide

2

TPAISILVSGFISTNTCPSTACTRAC

27

TPA+S+ ++G+IS+NTCP+TACTRAC

2

TPALSV-ITGYISSNTCPTTACTRAC

26

with 74 more sequence matches

Only the first 10 are displayed here.

66.7%

NZ_JALAPU010000003.1and 7 others:

NZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07925_lanthipeptideNZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00585_lanthipeptideNZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00585_lanthipeptideNZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17010_lanthipeptideNZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17010_lanthipeptideNZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04640_lanthipeptideNZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04640_lanthipeptide

Lanthipeptides: MOD17_RS07925_lanthipeptide

2

TPAISILVSGFISTNTCPSTACTRAC

27

TPA+S+ V+ +IS+NTCP+TACTRAC

2

TPALSV-VTAYISSNTCPTTACTRAC

26

66.7%

NZ_NUIO01000031.1and 1 other:

NZ_NUIO01000031.1 Lanthipeptides: CN977_RS23165_lanthipeptide

Lanthipeptides: CN977_RS23165_lanthipeptide

1

VTPAISIL---VSGFISTNTCPSTACTRAC

27

+TP +SI VSG+IS+NTCP+TACTRAC

1

ITPTVSIALTAVSGYISSNTCPTTACTRAC

30

60.7%

NZ_PCGR01000003.1and 1 other:

NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09625_lanthipeptide

Lanthipeptides: CQS04_RS09625_lanthipeptide

2

TPAISI-LVSGFISTNTCPSTACTRAC

27

TP I I ++G+IS N+CP+TACTRAC

2

TPTIVITAITGYISANSCPTTACTRAC

28

60.0%

NZ_QGEE01000020.1and 3 others:

NZ_QGEE01000020.1 Lanthipeptides: DKP74_RS06165_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05385_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05385_lanthipeptide

Lanthipeptides: DKP74_RS06165_lanthipeptide

2

TPAI---SILVSGFISTNTCPSTACTRAC

27

TP I +++VSGF+S++TCP+TACTRAC

2

TPVIGYSAVIVSGFVSSHTCPTTACTRAC

30

59.3%

NZ_KE384533.1and 2 others:

NZ_KE384533.1 Lanthipeptides: K329_RS31315_lanthipeptideNZ_KE384533.1 Lanthipeptides: K329_RS31315_lanthipeptide

Lanthipeptides: K329_RS31315_lanthipeptide

2

TPAISI-LVSGFISTNTCPSTACTRAC

27

TP I I +VS ++STNTCP+T+CT C

1

TPTIVISVVSAYVSTNTCPTTSCTDEC

27

54.8%

NZ_AP026714.1and 21 others:

NZ_AP026714.1 Lanthipeptides: PO853_RS06520_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11270_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11270_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03990_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03990_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09815_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09815_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00090_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00090_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07695_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07695_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03740_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03740_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00125_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00125_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07745_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07745_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04680_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04680_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07985_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07985_lanthipeptide

Lanthipeptides: PO853_RS06520_lanthipeptide

1

VTPAISILVSGFISTNTCPSTACTRAC

27

+T ISI VSG+IS TCP++ CTRAC

5

ITIPISIAVSGWISDKTCPTSVCTRAC

31

53.6%

NZ_CP051884.1and 3 others:

NZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptide

Lanthipeptides: HGK68_RS15130_lanthipeptide

8

LVSGFISTNTCPSTACTRAC

27

+VS +IS NTCPS+ACTRAC

9

IVSAWISNNTCPSSACTRAC

28

51.5%

NZ_MIFN01000022.1and 1 other:

NZ_MIFN01000022.1 Lanthipeptides: BHL26_RS15355_lanthipeptide

Lanthipeptides: BHL26_RS15355_lanthipeptide

9

VSGFISTNTCPSTACTRAC

27

VSG+IS+NTCPSTACTRAC

15

VSGYISSNTCPSTACTRAC

33

50.0%

NZ_CACZYW010000004.1and 3 others:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide

Lanthipeptides: HUF10_RS02820_lanthipeptide

2

TPAISILV--SGFISTNTCPSTACTRAC

27

TPA ++V S ++S TCP+TACTRAC

5

TPATPVIVAVSAYVSDKTCPTTACTRAC

32

46.2%

NZ_BLIS01000009.1and 5 others:

NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04825_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptide

Lanthipeptides: GVO03_RS04825_lanthipeptide

2

TPAIS---ILVSGFISTNTCPSTACTRAC

27

TPAI I V+ F+S NTCP++ACTRAC

11

TPAIGKGVIAVTAFVSANTCPTSACTRAC

39

MIBiG 4.0 matches for EI692_RS18435

27.0%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

4

AISILVSGFISTNTCPSTACTRAC

27

AI V+ +S CP+T CT C

14

AIQAGVAVGVSAAFCPTTKCTSRC

37

22.2%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

18

CPSTACTRAC

27

CP+T CT C

17

CPTTKCTSKC

26

EI692_RS18440

Leader:

MKNEVNKLQKEEQVTWFEEIVDQEFDDDVFGA

Core:

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

Core with dehydrations:

CysDhaDhbNDhbFDhaLDhaDYWGNKGGWCysDhbIDhaHECysMDhaWCysK

antiSMASH-DB 4.0 matches for EI692_RS18440

100.0%

NZ_CP034414.1and 1 other:

NZ_CP034414.1 Lanthipeptides: EI692_RS18440_lanthipeptide

Lanthipeptides: EI692_RS18440_lanthipeptide

1

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

30

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

1

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

30

90.0%

NZ_CP061868.1and 1 other:

NZ_CP061868.1 Lanthipeptides: IE339_RS06330_lanthipeptide

Lanthipeptides: IE339_RS06330_lanthipeptide

1

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

30

C+TNTFSLSDYWGNKGGWCT +HECMSWCK

1

CTTNTFSLSDYWGNKGGWCTATHECMSWCK

30

90.0%

NZ_FMPI01000012.1and 1 other:

NZ_FMPI01000012.1 Lanthipeptides: BJR39_RS08305_lanthipeptide

Lanthipeptides: BJR39_RS08305_lanthipeptide

1

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

30

CSTNTFSLSDYWGN G WCT SHECMSWCK

1

CSTNTFSLSDYWGNNGNWCTASHECMSWCK

30

with 101 more sequence matches

Only the first 10 are displayed here.

86.7%

NZ_CACZYW010000004.1and 1 other:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02825_lanthipeptide

Lanthipeptides: HUF10_RS02825_lanthipeptide

1

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

30

CSTNTFSLSDYWGN G WCT+SHECM+WCK

1

CSTNTFSLSDYWGNNGNWCTLSHECMAWCK

30

86.7%

NZ_CP027862.1and 1 other:

NZ_CP027862.1 Lanthipeptides: allorf_0097945_0098112_lanthipeptide

Lanthipeptides: allorf_0097945_0098112_lanthipeptide

1

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

30

CSTNTFSLSDYWGN+G WCT++HECMSWCK

1

CSTNTFSLSDYWGNRGYWCTLTHECMSWCK

30

86.7%

NZ_CP051884.1and 2 others:

NZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptide

Lanthipeptides: HGK68_RS15125_lanthipeptide

1

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

30

CSTNTFSLSDYWGN G CTI+HECMSWCK

1

CSTNTFSLSDYWGNNGWLCTITHECMSWCK

30

86.7%

NZ_FNHR01000005.1and 1 other:

NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05590_lanthipeptide

Lanthipeptides: BLQ37_RS05590_lanthipeptide

1

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

30

CSTNTFSLSDY GN G WCTISHECM+WCK

1

CSTNTFSLSDYMGNNGNWCTISHECMAWCK

30

86.7%

NZ_QGEE01000020.1and 5 others:

NZ_QGEE01000020.1 Lanthipeptides: DKP74_RS06160_lanthipeptideNZ_QGEF01000018.1 Lanthipeptides: DKP75_RS05595_lanthipeptideNZ_QGEF01000018.1 Lanthipeptides: DKP75_RS05595_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05380_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05380_lanthipeptide

Lanthipeptides: DKP74_RS06160_lanthipeptide

1

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

30

CSTNTFSLSDYWGN+G WCT+SHECM+WCK

1

CSTNTFSLSDYWGNRGNWCTLSHECMAWCK

30

83.3%

NZ_AP026714.1and 21 others:

NZ_AP026714.1 Lanthipeptides: PO853_RS06515_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11265_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11265_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03985_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03985_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09810_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09810_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00085_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00085_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07700_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07700_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03735_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03735_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00120_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00120_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07750_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07750_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04675_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04675_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07990_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07990_lanthipeptide

Lanthipeptides: PO853_RS06515_lanthipeptide

1

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

30

C+TNTFSLSDYWGNKG WCT +HECM WCK

1

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

30

83.3%

NZ_BLIS01000009.1and 7 others:

NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04820_lanthipeptideNZ_LR134317.1 Lanthipeptides: EL136_RS01685_lanthipeptideNZ_LR134317.1 Lanthipeptides: EL136_RS01685_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02620_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02620_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01935_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01935_lanthipeptide

Lanthipeptides: GVO03_RS04820_lanthipeptide

1

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

30

C+TNTFSLSDYWGNKG WCT++HECM+WCK

1

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

30

83.3%

NZ_CP016767.1and 11 others:

NZ_CP016767.1 Lanthipeptides: BCV50_RS13410_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15325_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15325_lanthipeptideNZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07920_lanthipeptideNZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07920_lanthipeptideNZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00580_lanthipeptideNZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00580_lanthipeptideNZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17015_lanthipeptideNZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17015_lanthipeptideNZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04645_lanthipeptideNZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04645_lanthipeptide

Lanthipeptides: BCV50_RS13410_lanthipeptide

1

CSTNTFSLSDYWGNKGGWCTISHECMSWC

29

C+TNTFSLSDYWGNKGGWCT+S ECM+WC

1

CTTNTFSLSDYWGNKGGWCTVSKECMAWC

29

83.3%

NZ_MIFN01000022.1and 1 other:

NZ_MIFN01000022.1 Lanthipeptides: BHL26_RS15350_lanthipeptide

Lanthipeptides: BHL26_RS15350_lanthipeptide

1

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

30

C+TNTFSLSDYWGN G WC++SHECMSWCK

1

CTTNTFSLSDYWGNDGSWCSLSHECMSWCK

30

83.3%

NZ_PCGR01000003.1and 1 other:

NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09620_lanthipeptide

Lanthipeptides: CQS04_RS09620_lanthipeptide

1

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

30

C+TNTFSLSDYWGN G WCT +HECMSWCK

1

CTTNTFSLSDYWGNNGNWCTATHECMSWCK

30

MIBiG 4.0 matches for EI692_RS18440

60.0%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

1

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

30

C+TNTFSLS+ GN GGWCT++ EC C

1

CTTNTFSLSNALGNNGGWCTLTKECQPNCN

30

36.7%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

6

FSLSDYWGNKGGWCTISHECMSWC

29

+++S GNKG +CT++ ECM C

4

YNISCRLGNKGAYCTLTVECMPSC

27

15.4%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

19

CTISHECMSWC

29

CT+S EC C

28

CTLSKECQPNC

38

allorf_3594412_3594594

Leader:

MTSAHQRLKNRSYG

Core:

ISITGEFSISQRKSYIVLPRRDRKAPLCRISMLHRITNFYIVCTCF

Core with dehydrations:

IDhaIDhbGEFDhaIDhaQRKDhaYIVLPRRDRKAPLCysRIDhaMLHRIDhbNFYIVCysDhbCysF

antiSMASH-DB 4.0 matches for allorf_3594412_3594594

100.0%

NZ_CP034414.1:

Lanthipeptides: allorf_3594412_3594594_lanthipeptide

1

ISITGEFSISQRKSYIVLPRRDRKAPLCRISMLHRITNFYIVCTCF

46

ISITGEFSISQRKSYIVLPRRDRKAPLCRISMLHRITNFYIVCTCF

1

ISITGEFSISQRKSYIVLPRRDRKAPLCRISMLHRITNFYIVCTCF

46

19.6%

NZ_CP010833.1and 2 others:

NZ_CP013738.1 Lanthipeptides: allorf_2656180_2656281_lanthipeptideNZ_LIXK01000002.1 Lanthipeptides: allorf_0351346_0351447_lanthipeptide

Lanthipeptides: allorf_5390411_5390512_lanthipeptide

25

APLCRISMLHRITN

38

APL R S+LHR T+

2

APLLRCSLLHRGTD

15

12.1%

NZ_CP114039.1:

Lanthipeptides: allorf_7147535_7147768_lanthipeptide

24

KAPLCRISMLHRITNFYIVCT

44

KA LCR+++L + CT

5

KASLCRVAVLLSGALSWSACT

25

MIBiG 4.0 matches for allorf_3594412_3594594

6.5%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

26

PLCRISML

33

P C+ L

9

PGCKTGAL

16

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.33 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.99 out of 26.06

Confidence: medium

Additional weak hits (1):

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.53 out of 32.74

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

EI692_RS18435 - Class II

Cleavage pHMM score: 0.80

RODEO score: 0

Monoisotopic mass: 2550.3 Da

Molecular weight: 2552.0 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2570.0 Da N = 1; 2588.0 Da N = 2; 2606.0 Da N = 3; 2624.0 Da N = 4; 2642.1 Da N = 5; 2660.1 Da N = 6

EI692_RS18440 - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 3286.4 Da

Molecular weight: 3288.7 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3306.7 Da N = 1; 3324.7 Da N = 2; 3342.7 Da N = 3; 3360.7 Da N = 4

allorf_3594412_3594594 - Class II

Cleavage pHMM score: -6.40

RODEO score: 0

Monoisotopic mass: 5286.9 Da

Molecular weight: 5290.3 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 5308.3 Da N = 1; 5326.3 Da N = 2; 5344.3 Da N = 3; 5362.4 Da N = 4; 5380.4 Da N = 5

EI692_RS18435 - Class II

Cleavage pHMM score: 0.80

RODEO score: 0

Monoisotopic mass: 2550.3 Da

Molecular weight: 2552.0 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2570.0 Da N = 1; 2588.0 Da N = 2; 2606.0 Da N = 3; 2624.0 Da N = 4; 2642.1 Da N = 5; 2660.1 Da N = 6

EI692_RS18440 - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 3286.4 Da

Molecular weight: 3288.7 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3306.7 Da N = 1; 3324.7 Da N = 2; 3342.7 Da N = 3; 3360.7 Da N = 4

allorf_3594412_3594594 - Class II

Cleavage pHMM score: -6.40

RODEO score: 0

Monoisotopic mass: 5286.9 Da

Molecular weight: 5290.3 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 5308.3 Da N = 1; 5326.3 Da N = 2; 5344.3 Da N = 3; 5362.4 Da N = 4; 5380.4 Da N = 5

TFBS definitions

Regulator	Description
MogR	Repressor of flagellar motility genes

NZ_CP034414.1 - Region 12 - NRP-metallophore,NRPS

Download region GenBank file

Download region SVG

Location: 3,612,611 - 3,664,340 nt. (total: 51,730 nt) Show pHMM detection rules used

NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

EI692_RS18635: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

EI692_RS18670: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acyltransferase

EI692_RS18690: polyketide synthase associated protein papA3

smcogs: SMCOG1209: polyketide synthase associated protein papA3

Hydrolases: esterase hydrolase

EI692_RS18685: isochorismatase

smcogs: SMCOG1027: isochorismatase

EI692_RS18710: enterobactin/ferric enterobactin esterase

smcogs: SMCOG1098: enterobactin/ferric enterobactin esterase

Isomerases: isomerase

EI692_RS18675: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: ligase

EI692_RS18680: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000309.5	1.04	NRPS	bacillibactin	Bacillus subtilis subsp. subtilis str. 168
BGC0001185.5	1.04	NRPS	bacillibactin	Bacillus velezensis FZB42
BGC0000401.5	1.02	NRPS	paenibactin	Paenibacillus elgii B69
BGC0000343.5	0.85	NRPS	enterobactin	Pseudomonas sp. J465
BGC0002075.3	0.85	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001132.4	0.77	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.76	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002695.2	0.75	NRPS	bacillibactin, bacillibactin E, bacillibactin F	Bacillus sp. WMMC1349
BGC0001128.4	0.74	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.74	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000309.5	0.80	NRPS	bacillibactin	Bacillus subtilis subsp. subtilis str. 168
BGC0001185.5	0.80	NRPS	bacillibactin	Bacillus velezensis FZB42
BGC0000401.5	0.79	NRPS	paenibactin	Paenibacillus elgii B69
BGC0000343.5	0.74	NRPS	enterobactin	Pseudomonas sp. J465
BGC0002075.3	0.74	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001132.4	0.71	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.70	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002695.2	0.70	NRPS	bacillibactin, bacillibactin E, bacillibactin F	Bacillus sp. WMMC1349
BGC0001128.4	0.70	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.86 out of 26.06

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.52 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.52 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.00 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.67 out of 26.06

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.72 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.62 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.99 out of 29.38

Confidence: medium

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 27.08 out of 32.74

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.50 out of 29.38

Confidence: medium

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.54 out of 18.46

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.88 out of 29.38

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 25.16 out of 28.19

Confidence: strong

Additional weak hits (12):

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.47 out of 26.85

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.29 out of 25.75

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.89 out of 30.25

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.73 out of 30.25

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.20 out of 26.85

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.44 out of 32.74

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.88 out of 26.12

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.31 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 26.18 out of 32.74

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.94 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 26.21 out of 32.74

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.88 out of 26.06

Confidence: weak

Module view

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Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 14, location 3612610 - 3664340:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

EI692_RS18680: diOH-Bz

Search NORINE for peptide: strict or relaxed

AMP-binding (31..437): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: SKSLYPLSSPGGAVQVGGAQQVFGMAEGLVNYTR
Nearest Stachelhaus code(s):: diOH-Bz PLPAQGVVNK (94% 8Å match); diOH-Bz or Sal PLPAQGVVNK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

EI692_RS18690: Gly - Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (464..861): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FSMTFDISGLELQALVGGETNLYGPTETTIWSTM
Nearest Stachelhaus code(s):: Gly DILQLGLIWK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1521..1935): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LSTHFDFSVWEGNQIFGGEVNMYGITETTVHVTY
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
FuR variant 1	Ferric Uptake Regulator
FuR variant 2	Ferric Uptake Regulator
MogR	Repressor of flagellar motility genes
RpoN	Regulator of nitrogen assimilation and virulence
ZuR variant 1	Zinc-responsive repressor