Select genomic region:
Overview
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1.11
1.12

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP034414.1 (Bacillus safensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1 | NRPS | 291,556 | 375,270 | High | lichenysin | NRPS:Type I
Region 2 | RRE-containing | 821,302 | 842,207 |
Region 3 | terpene,NI-siderophore | 985,389 | 1,023,040 | Medium | schizokinen | NRPS:Type IV
Region 4 | betalactone | 1,756,897 | 1,785,309 | Medium | fengycin | NRPS:Type I
Region 5 | terpene | 1,860,208 | 1,882,082 |
Region 6 | T3PKS | 1,920,584 | 1,961,684 |
Region 7 | terpene-precursor | 2,128,736 | 2,149,626 |  |
Region 8 | RiPP-like | 2,268,876 | 2,279,202 |
Region 9 | betalactone | 2,419,189 | 2,451,641 |
Region 10 | other | 3,325,113 | 3,366,534 | High | bacilysin | other:other
Region 11 | lanthipeptide-class-ii | 3,573,189 | 3,600,852 | Medium | staphylococcin C55 α/staphylococcin C55 β | ribosomal:RiPP:Lanthipeptide
Region 12 | NRP-metallophore,NRPS | 3,612,611 | 3,664,340 | High | bacillibactin/bacillibactin E/bacillibactin F | NRPS:Type I

NZ_CP034414.1 - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 291,556 - 375,270 nt. (total: 83,715 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: PPTase aminotransferase
EI692_RS01790: aminotransferase

smcogs
  SMCOG1019: aminotransferase

EI692_RS01795: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: esterase
EI692_RS01780: thioesterase

smcogs
  SMCOG1004: thioesterase

Ligases: ligase
EI692_RS01755: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

EI692_RS01760: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

EI692_RS01765: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

EI692_RS01770: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

EI692_RS01775: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Translocases: permease transporter
EI692_RS01735: sugar-binding lipoprotein

smcogs
  SMCOG1143: sugar-binding lipoprotein

EI692_RS01850: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000381.5 |  | 0.76 | NRPS | lichenysin | Bacillus licheniformis DSM 13 = ATCC 14580
BGC0001833.4 |  | 0.75 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002135.2 |  | 0.75 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001128.4 |  | 0.73 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  | 0.73 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0002075.3 |  | 0.73 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0001132.4 |  | 0.73 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001758.4 |  | 0.73 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0002286.3 |  | 0.72 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4 |  | 0.72 | NRPS | xenematide | Xenorhabdus nematophila AN6/1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000381.5 |  | 0.76 | NRPS | lichenysin | Bacillus licheniformis DSM 13 = ATCC 14580
BGC0001833.4 |  | 0.75 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002135.2 |  | 0.75 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001128.4 |  | 0.73 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  | 0.73 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0002075.3 |  | 0.73 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0001132.4 |  | 0.73 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001758.4 |  | 0.73 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0002286.3 |  | 0.72 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4 |  | 0.72 | NRPS | xenematide | Xenorhabdus nematophila AN6/1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 16.87 out of 18.16
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.52 out of 29.72
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.49 out of 20.97
Confidence: medium
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.43 out of 32.93
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.25 out of 26.06
Confidence: medium
Additional weak hits (11):
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 21.73 out of 30.97
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.27 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.51 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.08 out of 26.06
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.46 out of 32.74
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.42 out of 28.14
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.25 out of 30.97
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.67 out of 36.53
Confidence: weak
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.83 out of 27.04
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.11 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.16 out of 26.06
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 291555 - 375270:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Glu - Leu - D-Leu) + (Ile - Asp - D-Leu) + (Ile) + (NH2 - D-Val) + (fatty_acid - Val)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
EI692_RS01755: Glu - Leu - Leu
Search NORINE for peptide: strict or relaxed
AMP-binding (463..868): Glu
nrpys: Glu

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    gln (Gln)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LALAFDASVKQADGLIGGEWNVYGPTETCVDAAV
  Nearest Stachelhaus code(s):
    Glu DAKDLGVVDK (91% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1504..1902): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TQSSFDAFMFDGMILFGGEVHMYGPSESTIFTTY
  Nearest Stachelhaus code(s):
    Leu DAFMLGMVFK (88% 8Å match)
  Stachelhaus code match:
    90% (moderate)

AMP-binding (2541..2921): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LWHAFDASIWEPFLLTGGDVNNYGPTENTVVATS
  Nearest Stachelhaus code(s):
    Leu DAWFLGNVVK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

EI692_RS01760: Ile - Asp - Leu
Search NORINE for peptide: strict or relaxed
AMP-binding (470..858): Ile
nrpys: Ile

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    ile (Ile)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LSQGFDAITLETFLFTGGDLNVYGPTENTTISTF
  Nearest Stachelhaus code(s):
    Ile DAFFLGVTFK (68% 8Å match)
    Val DAYFWGVTFK (59% 8Å match)
  Stachelhaus code match:
    70% (weak)

AMP-binding (1496..1894): Asp
nrpys: Asp

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asp (Asp)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWLSYDLGYTSPKMVLGGEMNHYGPTETTIGTVT
  Nearest Stachelhaus code(s):
    Asp DLTKVGHIGK (82% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (2536..2916): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LWHAFDASIWEPFLLTGGDVNNYGPTENTVVATS
  Nearest Stachelhaus code(s):
    Leu DAWFLGNVVK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

EI692_RS01765: Ile
Search NORINE for peptide: strict or relaxed
AMP-binding (467..866): Ile
nrpys: Ile

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    ile (Ile)

Stachelhaus prediction details:
  Stachelhaus sequence:
    VNTSFDGFTFDGFILFGGEINVYGPTESTVFATY
  Nearest Stachelhaus code(s):
    Ile DGFFLGVVFK (88% 8Å match)
  Stachelhaus code match:
    100% (strong)

EI692_RS01770: NH2 - Val
Search NORINE for peptide: strict or relaxed
CAL_domain (247..566): NH2
minowa: NH2

Prediction, score:
  NH2: 10.3
  Acetyl-CoA: 8.5
  shikimic_acid: 0.0
  AHBA: 0.0
  fatty_acid: -0.4

AMP-binding (1789..2185): Val
nrpys: Val

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    val (Val)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LETAFDAFTYEGFLLVGGDLNGYGPTENTTFSCV
  Nearest Stachelhaus code(s):
    Val DAYFLGGTFK (65% 8Å match)
  Stachelhaus code match:
    100% (strong)

EI692_RS01775: fatty_acid - Val
Search NORINE for peptide: strict or relaxed
CAL_domain (226..668): fatty_acid
minowa: fatty_acid

Prediction, score:
  fatty_acid: 21.8
  Acetyl-CoA: 9.4
  AHBA: 8.5
  shikimic_acid: 0.0
  NH2: 0.0

AMP-binding (1874..2272): Val
nrpys: Val

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LETSFDAFTFEGCLLVGGEVNAYGPTENTTLATT
  Nearest Stachelhaus code(s):
    Val DAFWLGATFK (71% 8Å match)
  Stachelhaus code match:
    80% (moderate)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CRP | Cyclic AMP receptor protein
CcpA | Catabolite control protein A
LexA variant 3 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
NtrC | Nitrogen regulatory protein C
ToxT | Regulator of MSHA biosynthesis

NZ_CP034414.1 - Region 2 - RRE-containing
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 821,302 - 842,207 nt. (total: 20,906 nt) Show pHMM detection rules used
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
EI692_RS04235: oxidoreductase

smcogs
  SMCOG1083: oxidoreductase

Transferases: sulfhydrylase
EI692_RS04210: O-succinylhomoserine sulfhydrylase

smcogs
  SMCOG1168: O-succinylhomoserine sulfhydrylase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RRE-containing | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002285.2 |  | 0.39 | ribosomal | aborycin | Streptomyces sp. ZS0098
BGC0002447.3 |  | 0.39 | ribosomal | cerecyclin | Bacillus cereus
BGC0000600.3 |  | 0.39 | ribosomal | thurincin H | Bacillus thuringiensis
BGC0001684.3 |  | 0.37 | other (other) | N-acyloxyacyl glutamine | Klebsiella variicola
BGC0002663.2 |  | 0.36 | ribosomal | amyloliquecidin GF610 | Bacillus amyloliquefaciens UMAF6639
BGC0002470.2 |  | 0.36 | other (other) | synechobactin C9, synechobactin C11, synechobactin 13, synechobactin 14, synechobactin 16, synechobactin A, synechobactin B, synechobactin C | Synechococcus sp. PCC 7002
BGC0000498.5 |  | 0.35 | ribosomal | bovicin HJ50 | Streptococcus equinus
BGC0000561.5 |  | 0.35 | ribosomal | thermophilin 1277 | Streptococcus thermophilus
BGC0000815.4 |  | 0.35 | other (other) | loline, N-acetylnorloline, N-formylloline | Epichloe uncinata
BGC0001606.3 |  | 0.35 | PKS | gibepyrone-A | Fusarium fujikuroi IMI 58289

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002285.2 |  | 0.39 | ribosomal | aborycin | Streptomyces sp. ZS0098
BGC0002447.3 |  | 0.39 | ribosomal | cerecyclin | Bacillus cereus
BGC0000600.3 |  | 0.39 | ribosomal | thurincin H | Bacillus thuringiensis
BGC0001684.3 |  | 0.37 | other (other) | N-acyloxyacyl glutamine | Klebsiella variicola
BGC0002663.2 |  | 0.36 | ribosomal | amyloliquecidin GF610 | Bacillus amyloliquefaciens UMAF6639
BGC0002470.2 |  | 0.36 | other (other) | synechobactin C9, synechobactin C11, synechobactin 13, synechobactin 14, synechobactin 16, synechobactin A, synechobactin B, synechobactin C | Synechococcus sp. PCC 7002
BGC0000498.5 |  | 0.35 | ribosomal | bovicin HJ50 | Streptococcus equinus
BGC0000561.5 |  | 0.35 | ribosomal | thermophilin 1277 | Streptococcus thermophilus
BGC0000815.4 |  | 0.35 | other (other) | loline, N-acetylnorloline, N-formylloline | Epichloe uncinata
BGC0001606.3 |  | 0.35 | PKS | gibepyrone-A | Fusarium fujikuroi IMI 58289

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.49 out of 24.78
Confidence: medium
Additional weak hits (2):
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.80 out of 32.74
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 23.11 out of 29.65
Confidence: weak
RREFinder
TFBS Finder
RRE predictions
RREfinder results sidepanel.

RRE-containing protocluster (821301...842207)
EI692_RS04255
  RRE type: PqqD_RRE
  Location: 36 - 92
  Score: 35.6

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
LexA variant 2 | Repressor of DNA damage response

NZ_CP034414.1 - Region 3 - NI-siderophore,terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 985,389 - 1,023,040 nt. (total: 37,652 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)
NI-siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxygenase
EI692_RS05045: dehydrogenase

smcogs
  SMCOG1222: dehydrogenase

EI692_RS05050: dehydrogenase

smcogs
  SMCOG1222: dehydrogenase

EI692_RS05110: lysine/ornithine N-monooxygenase

smcogs
  SMCOG1080: lysine/ornithine N-monooxygenase

Transferases: acetyltransferase aminotransferase
EI692_RS05070: GCN5-related N-acetyltransferase

smcogs
  SMCOG1111: GCN5-related N-acetyltransferase

EI692_RS05090: aminotransferase class-III

smcogs
  SMCOG1013: aminotransferase class-III

Hydrolases: hydrolase
EI692_RS05040: asparagine synthase (glutamine-hydrolyzing)

smcogs
  SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Lyases: decarboxylase
EI692_RS05095: Decarboxylase, pyridoxal-dependent

smcogs
  SMCOG1180: Decarboxylase, pyridoxal-dependent

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | NI-siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000647.3 |  |  | 0.91 | terpene | carotenoid | Rhodobacter sphaeroides
BGC0002633.2 |  |  | 0.60 | other (other) | schizokinen | Leptolyngbya sp. PCC 7376
BGC0002469.2 |  |  | 0.55 | other (other) | woodybactin A, woodybactin B, woodybactin C, woodybactin D | Shewanella woodyi ATCC 51908
BGC0002683.2 |  |  | 0.55 | NRPS | schizokinen | Nostoc sp. PCC 7120 = FACHB-418
BGC0001572.3 |  |  | 0.50 | other (other) | desferrioxamine E | Pantoea agglomerans
BGC0000645.3 |  |  | 0.50 | terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0001478.5 |  |  | 0.48 | other (other) | desferrioxamine E | Streptomyces sp. ID38640
BGC0002692.2 |  |  | 0.46 | other (other) | speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B | Kribbella speibonae
BGC0000941.3 |  |  | 0.46 | other (other) | desferrioxamin B | Streptomyces griseus subsp. griseus NBRC 13350
BGC0002305.2 |  |  | 0.45 | other (other) | legonoxamine A, desferrioxamine B, legonoxamine B | Streptomyces sp.

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000647.3 |  | 0.76 | terpene | carotenoid | Rhodobacter sphaeroides
BGC0002469.2 |  | 0.67 | other (other) | woodybactin A, woodybactin B, woodybactin C, woodybactin D | Shewanella woodyi ATCC 51908
BGC0002633.2 |  | 0.66 | other (other) | schizokinen | Leptolyngbya sp. PCC 7376
BGC0002683.2 |  | 0.64 | NRPS | schizokinen | Nostoc sp. PCC 7120 = FACHB-418
BGC0001572.3 |  | 0.62 | other (other) | desferrioxamine E | Pantoea agglomerans
BGC0001478.5 |  | 0.61 | other (other) | desferrioxamine E | Streptomyces sp. ID38640
BGC0002692.2 |  | 0.60 | other (other) | speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B | Kribbella speibonae
BGC0000941.3 |  | 0.60 | other (other) | desferrioxamin B | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001531.5 |  | 0.59 | other (other) | bisucaberin B | Tenacibaculum mesophilum
BGC0002305.2 |  | 0.59 | other (other) | legonoxamine A, desferrioxamine B, legonoxamine B | Streptomyces sp.

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene | C30 carotenoid | diapophytoene | C30 | acyclic | none

Genes with terpene domains:
EI692_RS05055: PT_phytoene_like
Domain 1 (5 - 278): Prenyltransferase; Phytoene synthase like
Subtype: Diapophytoene synthase

Reactions:
  FPP → diapophytoene

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 24.36 out of 29.25
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.33 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.42 out of 29.38
Confidence: medium
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.53 out of 25.88
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.47 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.18 out of 28.19
Confidence: medium
Additional weak hits (6):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.77 out of 26.06
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.41 out of 29.38
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.44 out of 29.38
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.93 out of 29.38
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.46 out of 29.38
Confidence: weak
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 20.93 out of 29.72
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
FPP | Farnesyl diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
FuR variant 1 | Ferric Uptake Regulator
PsrA | Oleic acid responsive regulator
SypG | Regulator of biofilm formation and host colonization
ZuR variant 1 | Zinc-responsive repressor

NZ_CP034414.1 - Region 4 - betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,756,897 - 1,785,309 nt. (total: 28,413 nt) Show pHMM detection rules used
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
EI692_RS08995: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

EI692_RS09050: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

Transferases: carboxylase transferase
EI692_RS09020: acetyl-CoA carboxylase, carboxyl transferase,

smcogs
  SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

EI692_RS09040: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Lyases: hydratase
EI692_RS09025: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase
EI692_RS09015: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

EI692_RS09030: 2-isopropylmalate synthase

smcogs
  SMCOG1271: 2-isopropylmalate synthase

EI692_RS09045: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001135.5 |  | 0.55 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001268.4 |  | 0.54 | NRPS, PKS | fusarin C | Fusarium fujikuroi
BGC0002284.3 |  | 0.52 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0001160.5 |  | 0.52 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0001164.3 |  | 0.52 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0001103.5 |  | 0.50 | NRPS, PKS | mycosubtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000706.3 |  | 0.45 | saccharide | kanamycin | Streptomyces kanamyceticus
BGC0002405.2 |  | 0.45 | saccharide | mid-chain acyl sugars | Solanum lycopersicum
BGC0001095.5 |  | 0.44 | NRPS | fengycin | Bacillus velezensis FZB42
BGC0002020.3 |  | 0.44 | NRPS, saccharide | photolose, oligosaccharide 1 (GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 2 (GlcNAc-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 3 (GlcNAc-β(1-4)-GlcNAc-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 4 (GlcN-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 5 (6-phosphoGlcN-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc) | Photorhabdus laumondii subsp. laumondii TTO1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001135.5 |  | 0.55 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001268.4 |  | 0.54 | NRPS, PKS | fusarin C | Fusarium fujikuroi
BGC0002284.3 |  | 0.52 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0001160.5 |  | 0.52 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0001164.3 |  | 0.52 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0001103.5 |  | 0.50 | NRPS, PKS | mycosubtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000706.3 |  | 0.45 | saccharide | kanamycin | Streptomyces kanamyceticus
BGC0002405.2 |  | 0.45 | saccharide | mid-chain acyl sugars | Solanum lycopersicum
BGC0001095.5 |  | 0.44 | NRPS | fengycin | Bacillus velezensis FZB42
BGC0002020.3 |  | 0.44 | NRPS, saccharide | photolose, oligosaccharide 1 (GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 2 (GlcNAc-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 3 (GlcNAc-β(1-4)-GlcNAc-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 4 (GlcN-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 5 (6-phosphoGlcN-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc) | Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.12 out of 20.97
Confidence: strong
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 22.38 out of 26.33
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.69 out of 27.78
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.68 out of 27.55
Confidence: medium
Additional weak hits (2):
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.70 out of 29.25
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 19.16 out of 30.12
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM | Regulator of nitrogen-fixation genes

NZ_CP034414.1 - Region 5 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,860,208 - 1,882,082 nt. (total: 21,875 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
EI692_RS09445: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002173.2 |  | 0.46 | saccharide, terpene | fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol | Aspergillus fumigatus A1163
BGC0001535.3 |  | 0.42 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0000313.4 |  | 0.36 | NRPS | beauvericin | Beauveria bassiana
BGC0000670.4 |  | 0.34 | terpene | thalianol, thaliandiol, thalianin | Arabidopsis thaliana
BGC0002255.3 |  | 0.33 | PKS | lijiquinone | Ascomycota sp. F53
BGC0001575.4 |  | 0.31 | NRPS | PZN5, PZN6, PZN7, PZN9, PZN10, PZN11 | Ruminococcus sp. 5_1_39BFAA
BGC0001865.4 |  | 0.30 | PKS | elsinochrome C | Parastagonospora nodorum SN15
BGC0000663.5 |  | 0.30 | terpene | hopene | Streptomyces coelicolor A3(2)
BGC0000154.4 |  | 0.28 | PKS | stipitatic acid | Talaromyces stipitatus ATCC 10500
BGC0001739.3 |  | 0.28 | other (other) | phosphonoacetic Acid | Streptomyces sp. NRRL F-525

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002173.2 |  | 0.46 | saccharide, terpene | fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol | Aspergillus fumigatus A1163
BGC0001535.3 |  | 0.42 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0000313.4 |  | 0.36 | NRPS | beauvericin | Beauveria bassiana
BGC0000670.4 |  | 0.34 | terpene | thalianol, thaliandiol, thalianin | Arabidopsis thaliana
BGC0002255.3 |  | 0.33 | PKS | lijiquinone | Ascomycota sp. F53
BGC0001575.4 |  | 0.31 | NRPS | PZN5, PZN6, PZN7, PZN9, PZN10, PZN11 | Ruminococcus sp. 5_1_39BFAA
BGC0001865.4 |  | 0.30 | PKS | elsinochrome C | Parastagonospora nodorum SN15
BGC0000663.5 |  | 0.30 | terpene | hopene | Streptomyces coelicolor A3(2)
BGC0000154.4 |  | 0.28 | PKS | stipitatic acid | Talaromyces stipitatus ATCC 10500
BGC0001739.3 |  | 0.28 | other (other) | phosphonoacetic Acid | Streptomyces sp. NRRL F-525

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene | hopanoid |  | C30 | hopanoid skeleton | unknown
triterpene | polypodane |  | C30 | polypodane skeleton | unknown

Genes with terpene domains:
EI692_RS09450: T2TS
Domain 1 (8 - 620): Type 2 terpene synthase
Subtype: Squalene substrate

Reactions:
  squalene → hopanoid
  squalene → polypodane

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.12 out of 20.97
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.53 out of 26.06
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 26.67 out of 27.78
Confidence: strong
Additional weak hits (3):
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 22.66 out of 26.12
Confidence: weak
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.41 out of 25.75
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.89 out of 30.25
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.
No acronyms to display
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis

NZ_CP034414.1 - Region 6 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,920,584 - 1,961,684 nt. (total: 41,101 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
EI692_RS09920: NADH:flavin oxidoreductase/NADH oxidase

smcogs
  SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

Transferases: methyltransferase
EI692_RS09845: isoprenylcysteine carboxyl methyltransferase

smcogs
  SMCOG1150: isoprenylcysteine carboxyl methyltransferase

Hydrolases: deacetylase
EI692_RS09855: polysaccharide deacetylase

smcogs
  SMCOG1235: polysaccharide deacetylase

Ligases: synthase
EI692_RS09850: chalcone and stilbene synthase domain protein

smcogs
  SMCOG1024: chalcone and stilbene synthase domain protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001831.3 |  | 0.51 | PKS | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0001310.5 |  | 0.49 | PKS | naringenin | Streptomyces clavuligerus ATCC 27064
BGC0000282.3 |  | 0.49 | PKS | 2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol | Streptomyces griseus subsp. griseus NBRC 13350
BGC0002127.3 |  | 0.47 | PKS | flaviolin, 1,3,6,8-tetrahydroxynaphthalene | Streptomyces coelicolor A3(2)
BGC0001962.3 |  | 0.45 | PKS | hierridin B, hierridin C | Cyanobium sp. LEGE 06113
BGC0001475.4 |  | 0.42 | terpene | aspterric acid | Aspergillus terreus NIH2624
BGC0002332.2 |  | 0.42 | PKS | 4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A | Candidatus Entotheonella sp.
BGC0001267.3 |  | 0.36 | terpene | elymoclavine, Agroclavine I | Claviceps fusiformis
BGC0000348.4 |  | 0.36 | NRPS | ergovaline | Epichloe festucae var. lolii
BGC0001304.3 |  | 0.35 | PKS | aflavarin | Aspergillus flavus NRRL3357

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001831.3 |  | 0.51 | PKS | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0001310.5 |  | 0.49 | PKS | naringenin | Streptomyces clavuligerus ATCC 27064
BGC0000282.3 |  | 0.49 | PKS | 2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol | Streptomyces griseus subsp. griseus NBRC 13350
BGC0002127.3 |  | 0.47 | PKS | flaviolin, 1,3,6,8-tetrahydroxynaphthalene | Streptomyces coelicolor A3(2)
BGC0001962.3 |  | 0.45 | PKS | hierridin B, hierridin C | Cyanobium sp. LEGE 06113
BGC0001475.4 |  | 0.42 | terpene | aspterric acid | Aspergillus terreus NIH2624
BGC0002332.2 |  | 0.42 | PKS | 4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A | Candidatus Entotheonella sp.
BGC0001267.3 |  | 0.36 | terpene | elymoclavine, Agroclavine I | Claviceps fusiformis
BGC0000348.4 |  | 0.36 | NRPS | ergovaline | Epichloe festucae var. lolii
BGC0001304.3 |  | 0.35 | PKS | aflavarin | Aspergillus flavus NRRL3357

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.37 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.42 out of 26.06
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 27.15 out of 29.38
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.98 out of 20.97
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.55 out of 27.78
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.39 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.91 out of 29.38
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.98 out of 20.97
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.46 out of 30.25
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.73 out of 28.19
Confidence: strong
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 21.29 out of 27.04
Confidence: medium
Additional weak hits (8):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.99 out of 26.06
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.80 out of 29.38
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 26.16 out of 32.74
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.52 out of 32.74
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 23.15 out of 30.22
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.34 out of 32.93
Confidence: weak
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.13 out of 25.75
Confidence: weak
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.01 out of 24.78
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator
DasR | N-acetylglucosamine dependent repressor
FuR variant 1 | Ferric Uptake Regulator
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_CP034414.1 - Region 7 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,128,736 - 2,149,626 nt. (total: 20,891 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: carboxylase
EI692_RS10955: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase
EI692_RS10920: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

EI692_RS10925: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002284.3 |  | 0.38 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000639.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0000638.3 |  | 0.37 | terpene | carotenoid | Pantoea ananatis
BGC0000640.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC404

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002284.3 |  | 0.38 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000639.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0000638.3 |  | 0.37 | terpene | carotenoid | Pantoea ananatis
BGC0000640.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC404

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
EI692_RS10925: PT_FPPS_like
Domain 1 (33 - 296): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  IPP, DMAPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.38 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.88 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.42 out of 27.78
Confidence: medium
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 22.67 out of 26.33
Confidence: medium
Additional weak hits (1):
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.47 out of 36.54
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis

NZ_CP034414.1 - Region 8 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,268,876 - 2,279,202 nt. (total: 10,327 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: deacetylase
EI692_RS11710: polysaccharide deacetylase

smcogs
  SMCOG1235: polysaccharide deacetylase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000489.3 |  | 0.59 | ribosomal | enterocin AS-48 | Enterococcus faecalis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000489.3 |  | 0.59 | ribosomal | enterocin AS-48 | Enterococcus faecalis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.28 out of 26.06
Confidence: medium
Additional weak hits (2):
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 26.19 out of 31.73
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.81 out of 39.62
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
MogR | Repressor of flagellar motility genes

NZ_CP034414.1 - Region 9 - betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,419,189 - 2,451,641 nt. (total: 32,453 nt) Show pHMM detection rules used
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidase
EI692_RS12555: pyruvate oxidase/decarboxylase

smcogs
  SMCOG1055: pyruvate oxidase/decarboxylase

EI692_RS12610: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Ligases: ligase synthase
EI692_RS12540: 2-isopropylmalate synthase

smcogs
  SMCOG1271: 2-isopropylmalate synthase

EI692_RS12590: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002174.2 |  | 0.60 | NRPS | ε-Poly-L-lysine | Epichloe festucae
BGC0001261.3 |  | 0.60 | NRPS | AM-toxin | Alternaria alternata
BGC0000357.5 |  | 0.59 | NRPS | cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val) | Penicillium rubens Wisconsin 54-1255
BGC0001240.4 |  | 0.59 | NRPS | serinocyclin A, serinocyclin B | Metarhizium robertsii
BGC0002164.2 |  | 0.58 | NRPS | peramine | Epichloe festucae
BGC0002276.2 |  | 0.57 | NRPS | choline | Aspergillus nidulans FGSC A4
BGC0001268.4 |  | 0.55 | NRPS, PKS | fusarin C | Fusarium fujikuroi
BGC0002518.3 |  | 0.45 | NRPS | syringafactin A, syringafactin C | Pseudomonas sp. SZ57
BGC0001441.5 |  | 0.44 | other (other) | belactosin A, belactosin C | Streptomyces sp.
BGC0000308.5 |  | 0.43 | NRPS | aureusimine A, aureusimine B, aureusimine C | Staphylococcus aureus subsp. aureus str. JKD6008

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002174.2 |  | 0.60 | NRPS | ε-Poly-L-lysine | Epichloe festucae
BGC0001261.3 |  | 0.60 | NRPS | AM-toxin | Alternaria alternata
BGC0000357.5 |  | 0.59 | NRPS | cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val) | Penicillium rubens Wisconsin 54-1255
BGC0001240.4 |  | 0.59 | NRPS | serinocyclin A, serinocyclin B | Metarhizium robertsii
BGC0002164.2 |  | 0.58 | NRPS | peramine | Epichloe festucae
BGC0002276.2 |  | 0.57 | NRPS | choline | Aspergillus nidulans FGSC A4
BGC0001268.4 |  | 0.55 | NRPS, PKS | fusarin C | Fusarium fujikuroi
BGC0002518.3 |  | 0.45 | NRPS | syringafactin A, syringafactin C | Pseudomonas sp. SZ57
BGC0001441.5 |  | 0.44 | other (other) | belactosin A, belactosin C | Streptomyces sp.
BGC0000308.5 |  | 0.43 | NRPS | aureusimine A, aureusimine B, aureusimine C | Staphylococcus aureus subsp. aureus str. JKD6008

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.06 out of 27.78
Confidence: medium
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.85 out of 20.97
Confidence: medium
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.30 out of 25.31
Confidence: medium
Additional weak hits (5):
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 26.54 out of 36.54
Confidence: weak
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 20.93 out of 29.72
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.50 out of 31.73
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.57 out of 32.74
Confidence: weak
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsR | Pleiotropic regulatory for antibiotic production
CatR | H2O2-responsive repressor
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ToxT | Regulator of MSHA biosynthesis

NZ_CP034414.1 - Region 10 - other
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,325,113 - 3,366,534 nt. (total: 41,422 nt) Show pHMM detection rules used
other: (Neocarzinostat or bcpB or frbD or mitE or prnB or CaiA or bacilysin or orf2_PTase)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
EI692_RS17210: 3-hydroxyisobutyrate dehydrogenase

smcogs
  SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

EI692_RS17260: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

EI692_RS17275: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

EI692_RS17365: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

Transferases: aminotransferase transferase
EI692_RS17270: aminotransferase

smcogs
  SMCOG1019: aminotransferase

EI692_RS17295: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs
  SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

EI692_RS17320: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs
  SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

Lyases: dehydratase lyase
EI692_RS17265: argininosuccinate lyase/adenylosuccinate lyase

smcogs
  SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

EI692_RS17285: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

EI692_RS17290: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | other | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000888.5 |  | 0.77 | other (other) | bacilysin | Bacillus sp. CS93
BGC0001184.4 |  | 0.72 | other (other) | bacilysin | Bacillus velezensis FZB42
BGC0000898.5 |  | 0.56 | saccharide | desosamine, pikromycin, neomethymycin, narbomycin | Streptomyces venezuelae
BGC0000791.3 |  | 0.56 | saccharide | O-antigen | Cronobacter sakazakii
BGC0000790.3 |  | 0.55 | saccharide | O-antigen | Escherichia coli
BGC0000794.5 |  | 0.55 | saccharide | S-layer glycan | Geobacillus stearothermophilus
BGC0000773.3 |  | 0.55 | saccharide | lipopolysaccharide | Escherichia coli
BGC0000766.3 |  | 0.52 | saccharide | exopolysaccharide | Lactobacillus johnsonii
BGC0000792.3 |  | 0.52 | saccharide | polysaccharide | Enterococcus faecalis OG1RF
BGC0001817.5 |  | 0.52 | other (other) | vancosamine | Streptomyces sp. WAC2288

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000888.5 |  | 0.77 | other (other) | bacilysin | Bacillus sp. CS93
BGC0001184.4 |  | 0.72 | other (other) | bacilysin | Bacillus velezensis FZB42
BGC0000898.5 |  | 0.56 | saccharide | desosamine, pikromycin, neomethymycin, narbomycin | Streptomyces venezuelae
BGC0000791.3 |  | 0.56 | saccharide | O-antigen | Cronobacter sakazakii
BGC0000790.3 |  | 0.55 | saccharide | O-antigen | Escherichia coli
BGC0000794.5 |  | 0.55 | saccharide | S-layer glycan | Geobacillus stearothermophilus
BGC0000773.3 |  | 0.55 | saccharide | lipopolysaccharide | Escherichia coli
BGC0000766.3 |  | 0.52 | saccharide | exopolysaccharide | Lactobacillus johnsonii
BGC0000792.3 |  | 0.52 | saccharide | polysaccharide | Enterococcus faecalis OG1RF
BGC0001817.5 |  | 0.52 | other (other) | vancosamine | Streptomyces sp. WAC2288

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Location:
Identifier
Identity
Coverage
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.53 out of 26.06
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.26 out of 26.06
Confidence: strong
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.58 out of 21.84
Confidence: medium
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 18.33 out of 19.52
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.39 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.64 out of 26.06
Confidence: medium
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.38 out of 25.88
Confidence: medium
Additional weak hits (1):
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsQ1 | Two-component system AfsQ1-Q2, activator of antibiotic production
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MexT | Global virulence regulator
MogR | Repressor of flagellar motility genes
PsrA | Oleic acid responsive regulator

NZ_CP034414.1 - Region 11 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,573,189 - 3,600,852 nt. (total: 27,664 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
EI692_RS18415: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs
  SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: phosphotransferase
EI692_RS18385: Glucose-specific phosphotransferase enzyme IIA

smcogs
  SMCOG1145: Glucose-specific phosphotransferase enzyme IIA

Hydrolases: hydrolase
EI692_RS18465: metallo-beta-lactamase family protein

smcogs
  SMCOG1170: metallo-beta-lactamase family protein

Lyases: cyclase
EI692_RS18420: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

EI692_RS18430: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000520.5 |  | 0.78 | ribosomal | lacticin 3147 A1, lacticin 3147 A2 | Lactococcus lactis
BGC0000555.3 |  | 0.72 | ribosomal | staphylococcin C55 α, staphylococcin C55 β | Staphylococcus aureus
BGC0001229.4 |  | 0.63 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0002110.3 |  | 0.61 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0001391.3 |  | 0.55 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni
BGC0000517.4 |  | 0.51 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0001311.5 |  | 0.51 | ribosomal | flavecins | Ruminococcus flavefaciens FD-1
BGC0002663.2 |  | 0.51 | ribosomal | amyloliquecidin GF610 | Bacillus amyloliquefaciens UMAF6639
BGC0002005.2 |  | 0.50 | ribosomal | RaxX | Xanthomonas oryzae pv. oryzae
BGC0000552.3 |  | 0.50 | ribosomal | SmbA, SmbB | Streptococcus mutans

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000520.5 |  | 0.78 | ribosomal | lacticin 3147 A1, lacticin 3147 A2 | Lactococcus lactis
BGC0000555.3 |  | 0.72 | ribosomal | staphylococcin C55 α, staphylococcin C55 β | Staphylococcus aureus
BGC0001229.4 |  | 0.63 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0002110.3 |  | 0.61 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0001391.3 |  | 0.55 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni
BGC0000517.4 |  | 0.51 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0001311.5 |  | 0.51 | ribosomal | flavecins | Ruminococcus flavefaciens FD-1
BGC0002663.2 |  | 0.51 | ribosomal | amyloliquecidin GF610 | Bacillus amyloliquefaciens UMAF6639
BGC0002005.2 |  | 0.50 | ribosomal | RaxX | Xanthomonas oryzae pv. oryzae
BGC0000552.3 |  | 0.50 | ribosomal | SmbA, SmbB | Streptococcus mutans

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for EI692_RS18420

EI692_RS18435
Leader:
MNDKNSKAKNGLNNELELGKYLESDMIALTDDDVAGG
Core:
VTPAISILVSGFISTNTCPSTACTRAC
Core with dehydrations:
VDhbPAIDhaILVDhaGFIDhaDhbNDhbCysPDhaDhbACysDhbRACys

#### antiSMASH-DB 4.0 matches for EI692_RS18435

100.0%
NZ_CP034414.1 and 1 other:
NZ_CP034414.1 Lanthipeptides: EI692_RS18435_lanthipeptide
Lanthipeptides: EI692_RS18435_lanthipeptide
1
VTPAISILVSGFISTNTCPSTACTRAC
27
VTPAISILVSGFISTNTCPSTACTRAC
1
VTPAISILVSGFISTNTCPSTACTRAC
27
67.9%
NZ_CP061868.1 and 1 other:
NZ_CP061868.1 Lanthipeptides: IE339_RS06335_lanthipeptide
Lanthipeptides: IE339_RS06335_lanthipeptide
1
VTPAISIL-VSGFISTNTCPSTACTRAC
27
+TP I I V+G+ISTNTCP+T+CTRAC
1
ITPTIVITAVTGYISTNTCPTTSCTRAC
28
66.7%
NZ_CP016767.1 and 3 others:
NZ_CP016767.1 Lanthipeptides: BCV50_RS13415_lanthipeptide NZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptide NZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptide
Lanthipeptides: BCV50_RS13415_lanthipeptide
2
TPAISILVSGFISTNTCPSTACTRAC
27
TPA+S+ ++G+IS+NTCP+TACTRAC
2
TPALSV-ITGYISSNTCPTTACTRAC
26
with 74 more sequence matches
Only the first 10 are displayed here.
66.7%
NZ_JALAPU010000003.1 and 7 others:
NZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07925_lanthipeptide NZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00585_lanthipeptide NZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00585_lanthipeptide NZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17010_lanthipeptide NZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17010_lanthipeptide NZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04640_lanthipeptide NZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04640_lanthipeptide
Lanthipeptides: MOD17_RS07925_lanthipeptide
2
TPAISILVSGFISTNTCPSTACTRAC
27
TPA+S+ V+ +IS+NTCP+TACTRAC
2
TPALSV-VTAYISSNTCPTTACTRAC
26
66.7%
NZ_NUIO01000031.1 and 1 other:
NZ_NUIO01000031.1 Lanthipeptides: CN977_RS23165_lanthipeptide
Lanthipeptides: CN977_RS23165_lanthipeptide
1
VTPAISIL---VSGFISTNTCPSTACTRAC
27
+TP +SI VSG+IS+NTCP+TACTRAC
1
ITPTVSIALTAVSGYISSNTCPTTACTRAC
30
60.7%
NZ_PCGR01000003.1 and 1 other:
NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09625_lanthipeptide
Lanthipeptides: CQS04_RS09625_lanthipeptide
2
TPAISI-LVSGFISTNTCPSTACTRAC
27
TP I I ++G+IS N+CP+TACTRAC
2
TPTIVITAITGYISANSCPTTACTRAC
28
60.0%
NZ_QGEE01000020.1 and 3 others:
NZ_QGEE01000020.1 Lanthipeptides: DKP74_RS06165_lanthipeptide NZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05385_lanthipeptide NZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05385_lanthipeptide
Lanthipeptides: DKP74_RS06165_lanthipeptide
2
TPAI---SILVSGFISTNTCPSTACTRAC
27
TP I +++VSGF+S++TCP+TACTRAC
2
TPVIGYSAVIVSGFVSSHTCPTTACTRAC
30
59.3%
NZ_KE384533.1 and 2 others:
NZ_KE384533.1 Lanthipeptides: K329_RS31315_lanthipeptide NZ_KE384533.1 Lanthipeptides: K329_RS31315_lanthipeptide
Lanthipeptides: K329_RS31315_lanthipeptide
2
TPAISI-LVSGFISTNTCPSTACTRAC
27
TP I I +VS ++STNTCP+T+CT C
1
TPTIVISVVSAYVSTNTCPTTSCTDEC
27
54.8%
NZ_AP026714.1 and 21 others:
NZ_AP026714.1 Lanthipeptides: PO853_RS06520_lanthipeptide NZ_CP028724.1 Lanthipeptides: C7I31_RS11270_lanthipeptide NZ_CP028724.1 Lanthipeptides: C7I31_RS11270_lanthipeptide NZ_CP092907.1 Lanthipeptides: MK744_RS03990_lanthipeptide NZ_CP092907.1 Lanthipeptides: MK744_RS03990_lanthipeptide NZ_KB944759.1 Lanthipeptides: WOA_RS09815_lanthipeptide NZ_KB944759.1 Lanthipeptides: WOA_RS09815_lanthipeptide NZ_KZ845892.1 Lanthipeptides: EB42_RS00090_lanthipeptide NZ_KZ845892.1 Lanthipeptides: EB42_RS00090_lanthipeptide NZ_KZ845958.1 Lanthipeptides: EB53_RS07695_lanthipeptide NZ_KZ845958.1 Lanthipeptides: EB53_RS07695_lanthipeptide NZ_LR607361.1 Lanthipeptides: FN738_RS03740_lanthipeptide NZ_LR607361.1 Lanthipeptides: FN738_RS03740_lanthipeptide NZ_LR607378.1 Lanthipeptides: FN751_RS00125_lanthipeptide NZ_LR607378.1 Lanthipeptides: FN751_RS00125_lanthipeptide NZ_LSFS01000007.1 Lanthipeptides: AW733_RS07745_lanthipeptide NZ_LSFS01000007.1 Lanthipeptides: AW733_RS07745_lanthipeptide NZ_NGMP01000002.1 Lanthipeptides: A5830_RS04680_lanthipeptide NZ_NGMP01000002.1 Lanthipeptides: A5830_RS04680_lanthipeptide NZ_NGMV01000001.1 Lanthipeptides: A5824_RS07985_lanthipeptide NZ_NGMV01000001.1 Lanthipeptides: A5824_RS07985_lanthipeptide
Lanthipeptides: PO853_RS06520_lanthipeptide
1
VTPAISILVSGFISTNTCPSTACTRAC
27
+T ISI VSG+IS TCP++ CTRAC
5
ITIPISIAVSGWISDKTCPTSVCTRAC
31
53.6%
NZ_CP051884.1 and 3 others:
NZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptide NZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptide NZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptide
Lanthipeptides: HGK68_RS15130_lanthipeptide
8
LVSGFISTNTCPSTACTRAC
27
+VS +IS NTCPS+ACTRAC
9
IVSAWISNNTCPSSACTRAC
28
51.5%
NZ_MIFN01000022.1 and 1 other:
NZ_MIFN01000022.1 Lanthipeptides: BHL26_RS15355_lanthipeptide
Lanthipeptides: BHL26_RS15355_lanthipeptide
9
VSGFISTNTCPSTACTRAC
27
VSG+IS+NTCPSTACTRAC
15
VSGYISSNTCPSTACTRAC
33
50.0%
NZ_CACZYW010000004.1 and 3 others:
NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptide NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide
Lanthipeptides: HUF10_RS02820_lanthipeptide
2
TPAISILV--SGFISTNTCPSTACTRAC
27
TPA ++V S ++S TCP+TACTRAC
5
TPATPVIVAVSAYVSDKTCPTTACTRAC
32
46.2%
NZ_BLIS01000009.1 and 5 others:
NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04825_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptide
Lanthipeptides: GVO03_RS04825_lanthipeptide
2
TPAIS---ILVSGFISTNTCPSTACTRAC
27
TPAI I V+ F+S NTCP++ACTRAC
11
TPAIGKGVIAVTAFVSANTCPTSACTRAC
39

#### MIBiG 4.0 matches for EI692_RS18435

27.0%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
4
AISILVSGFISTNTCPSTACTRAC
27
AI V+ +S CP+T CT C
14
AIQAGVAVGVSAAFCPTTKCTSRC
37
22.2%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
18
CPSTACTRAC
27
CP+T CT C
17
CPTTKCTSKC
26
EI692_RS18440
Leader:
MKNEVNKLQKEEQVTWFEEIVDQEFDDDVFGA
Core:
CSTNTFSLSDYWGNKGGWCTISHECMSWCK
Core with dehydrations:
CysDhaDhbNDhbFDhaLDhaDYWGNKGGWCysDhbIDhaHECysMDhaWCysK

#### antiSMASH-DB 4.0 matches for EI692_RS18440

100.0%
NZ_CP034414.1 and 1 other:
NZ_CP034414.1 Lanthipeptides: EI692_RS18440_lanthipeptide
Lanthipeptides: EI692_RS18440_lanthipeptide
1
CSTNTFSLSDYWGNKGGWCTISHECMSWCK
30
CSTNTFSLSDYWGNKGGWCTISHECMSWCK
1
CSTNTFSLSDYWGNKGGWCTISHECMSWCK
30
90.0%
NZ_CP061868.1 and 1 other:
NZ_CP061868.1 Lanthipeptides: IE339_RS06330_lanthipeptide
Lanthipeptides: IE339_RS06330_lanthipeptide
1
CSTNTFSLSDYWGNKGGWCTISHECMSWCK
30
C+TNTFSLSDYWGNKGGWCT +HECMSWCK
1
CTTNTFSLSDYWGNKGGWCTATHECMSWCK
30
90.0%
NZ_FMPI01000012.1 and 1 other:
NZ_FMPI01000012.1 Lanthipeptides: BJR39_RS08305_lanthipeptide
Lanthipeptides: BJR39_RS08305_lanthipeptide
1
CSTNTFSLSDYWGNKGGWCTISHECMSWCK
30
CSTNTFSLSDYWGN G WCT SHECMSWCK
1
CSTNTFSLSDYWGNNGNWCTASHECMSWCK
30
with 101 more sequence matches
Only the first 10 are displayed here.
86.7%
NZ_CACZYW010000004.1 and 1 other:
NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02825_lanthipeptide
Lanthipeptides: HUF10_RS02825_lanthipeptide
1
CSTNTFSLSDYWGNKGGWCTISHECMSWCK
30
CSTNTFSLSDYWGN G WCT+SHECM+WCK
1
CSTNTFSLSDYWGNNGNWCTLSHECMAWCK
30
86.7%
NZ_CP027862.1 and 1 other:
NZ_CP027862.1 Lanthipeptides: allorf_0097945_0098112_lanthipeptide
Lanthipeptides: allorf_0097945_0098112_lanthipeptide
1
CSTNTFSLSDYWGNKGGWCTISHECMSWCK
30
CSTNTFSLSDYWGN+G WCT++HECMSWCK
1
CSTNTFSLSDYWGNRGYWCTLTHECMSWCK
30
86.7%
NZ_CP051884.1 and 2 others:
NZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptide NZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptide
Lanthipeptides: HGK68_RS15125_lanthipeptide
1
CSTNTFSLSDYWGNKGGWCTISHECMSWCK
30
CSTNTFSLSDYWGN G CTI+HECMSWCK
1
CSTNTFSLSDYWGNNGWLCTITHECMSWCK
30
86.7%
NZ_FNHR01000005.1 and 1 other:
NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05590_lanthipeptide
Lanthipeptides: BLQ37_RS05590_lanthipeptide
1
CSTNTFSLSDYWGNKGGWCTISHECMSWCK
30
CSTNTFSLSDY GN G WCTISHECM+WCK
1
CSTNTFSLSDYMGNNGNWCTISHECMAWCK
30
86.7%
NZ_QGEE01000020.1 and 5 others:
NZ_QGEE01000020.1 Lanthipeptides: DKP74_RS06160_lanthipeptide NZ_QGEF01000018.1 Lanthipeptides: DKP75_RS05595_lanthipeptide NZ_QGEF01000018.1 Lanthipeptides: DKP75_RS05595_lanthipeptide NZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05380_lanthipeptide NZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05380_lanthipeptide
Lanthipeptides: DKP74_RS06160_lanthipeptide
1
CSTNTFSLSDYWGNKGGWCTISHECMSWCK
30
CSTNTFSLSDYWGN+G WCT+SHECM+WCK
1
CSTNTFSLSDYWGNRGNWCTLSHECMAWCK
30
83.3%
NZ_AP026714.1 and 21 others:
NZ_AP026714.1 Lanthipeptides: PO853_RS06515_lanthipeptide NZ_CP028724.1 Lanthipeptides: C7I31_RS11265_lanthipeptide NZ_CP028724.1 Lanthipeptides: C7I31_RS11265_lanthipeptide NZ_CP092907.1 Lanthipeptides: MK744_RS03985_lanthipeptide NZ_CP092907.1 Lanthipeptides: MK744_RS03985_lanthipeptide NZ_KB944759.1 Lanthipeptides: WOA_RS09810_lanthipeptide NZ_KB944759.1 Lanthipeptides: WOA_RS09810_lanthipeptide NZ_KZ845892.1 Lanthipeptides: EB42_RS00085_lanthipeptide NZ_KZ845892.1 Lanthipeptides: EB42_RS00085_lanthipeptide NZ_KZ845958.1 Lanthipeptides: EB53_RS07700_lanthipeptide NZ_KZ845958.1 Lanthipeptides: EB53_RS07700_lanthipeptide NZ_LR607361.1 Lanthipeptides: FN738_RS03735_lanthipeptide NZ_LR607361.1 Lanthipeptides: FN738_RS03735_lanthipeptide NZ_LR607378.1 Lanthipeptides: FN751_RS00120_lanthipeptide NZ_LR607378.1 Lanthipeptides: FN751_RS00120_lanthipeptide NZ_LSFS01000007.1 Lanthipeptides: AW733_RS07750_lanthipeptide NZ_LSFS01000007.1 Lanthipeptides: AW733_RS07750_lanthipeptide NZ_NGMP01000002.1 Lanthipeptides: A5830_RS04675_lanthipeptide NZ_NGMP01000002.1 Lanthipeptides: A5830_RS04675_lanthipeptide NZ_NGMV01000001.1 Lanthipeptides: A5824_RS07990_lanthipeptide NZ_NGMV01000001.1 Lanthipeptides: A5824_RS07990_lanthipeptide
Lanthipeptides: PO853_RS06515_lanthipeptide
1
CSTNTFSLSDYWGNKGGWCTISHECMSWCK
30
C+TNTFSLSDYWGNKG WCT +HECM WCK
1
CTTNTFSLSDYWGNKGNWCTATHECMGWCK
30
83.3%
NZ_BLIS01000009.1 and 7 others:
NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04820_lanthipeptide NZ_LR134317.1 Lanthipeptides: EL136_RS01685_lanthipeptide NZ_LR134317.1 Lanthipeptides: EL136_RS01685_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02620_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02620_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01935_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01935_lanthipeptide
Lanthipeptides: GVO03_RS04820_lanthipeptide
1
CSTNTFSLSDYWGNKGGWCTISHECMSWCK
30
C+TNTFSLSDYWGNKG WCT++HECM+WCK
1
CTTNTFSLSDYWGNKGNWCTLTHECMNWCK
30
83.3%
NZ_CP016767.1 and 11 others:
NZ_CP016767.1 Lanthipeptides: BCV50_RS13410_lanthipeptide NZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15325_lanthipeptide NZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15325_lanthipeptide NZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07920_lanthipeptide NZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07920_lanthipeptide NZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00580_lanthipeptide NZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00580_lanthipeptide NZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17015_lanthipeptide NZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17015_lanthipeptide NZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04645_lanthipeptide NZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04645_lanthipeptide
Lanthipeptides: BCV50_RS13410_lanthipeptide
1
CSTNTFSLSDYWGNKGGWCTISHECMSWC
29
C+TNTFSLSDYWGNKGGWCT+S ECM+WC
1
CTTNTFSLSDYWGNKGGWCTVSKECMAWC
29
83.3%
NZ_MIFN01000022.1 and 1 other:
NZ_MIFN01000022.1 Lanthipeptides: BHL26_RS15350_lanthipeptide
Lanthipeptides: BHL26_RS15350_lanthipeptide
1
CSTNTFSLSDYWGNKGGWCTISHECMSWCK
30
C+TNTFSLSDYWGN G WC++SHECMSWCK
1
CTTNTFSLSDYWGNDGSWCSLSHECMSWCK
30
83.3%
NZ_PCGR01000003.1 and 1 other:
NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09620_lanthipeptide
Lanthipeptides: CQS04_RS09620_lanthipeptide
1
CSTNTFSLSDYWGNKGGWCTISHECMSWCK
30
C+TNTFSLSDYWGN G WCT +HECMSWCK
1
CTTNTFSLSDYWGNNGNWCTATHECMSWCK
30

#### MIBiG 4.0 matches for EI692_RS18440

60.0%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
1
CSTNTFSLSDYWGNKGGWCTISHECMSWCK
30
C+TNTFSLS+ GN GGWCT++ EC C
1
CTTNTFSLSNALGNNGGWCTLTKECQPNCN
30
36.7%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
6
FSLSDYWGNKGGWCTISHECMSWC
29
+++S GNKG +CT++ ECM C
4
YNISCRLGNKGAYCTLTVECMPSC
27
15.4%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
19
CTISHECMSWC
29
CT+S EC C
28
CTLSKECQPNC
38
allorf_3594412_3594594
Leader:
MTSAHQRLKNRSYG
Core:
ISITGEFSISQRKSYIVLPRRDRKAPLCRISMLHRITNFYIVCTCF
Core with dehydrations:
IDhaIDhbGEFDhaIDhaQRKDhaYIVLPRRDRKAPLCysRIDhaMLHRIDhbNFYIVCysDhbCysF

#### antiSMASH-DB 4.0 matches for allorf_3594412_3594594

100.0%
NZ_CP034414.1:
Lanthipeptides: allorf_3594412_3594594_lanthipeptide
1
ISITGEFSISQRKSYIVLPRRDRKAPLCRISMLHRITNFYIVCTCF
46
ISITGEFSISQRKSYIVLPRRDRKAPLCRISMLHRITNFYIVCTCF
1
ISITGEFSISQRKSYIVLPRRDRKAPLCRISMLHRITNFYIVCTCF
46
19.6%
NZ_CP010833.1 and 2 others:
NZ_CP013738.1 Lanthipeptides: allorf_2656180_2656281_lanthipeptide NZ_LIXK01000002.1 Lanthipeptides: allorf_0351346_0351447_lanthipeptide
Lanthipeptides: allorf_5390411_5390512_lanthipeptide
25
APLCRISMLHRITN
38
APL R S+LHR T+
2
APLLRCSLLHRGTD
15
12.1%
NZ_CP114039.1:
Lanthipeptides: allorf_7147535_7147768_lanthipeptide
24
KAPLCRISMLHRITNFYIVCT
44
KA LCR+++L + CT
5
KASLCRVAVLLSGALSWSACT
25

#### MIBiG 4.0 matches for allorf_3594412_3594594

6.5%
BGC0000535.4 (ADJ56352.1):
Lanthipeptide: nisin A
26
PLCRISML
33
P C+ L
9
PGCKTGAL
16

#### Lanthipeptide(s) for EI692_RS18430

EI692_RS18435
Leader:
MNDKNSKAKNGLNNELELGKYLESDMIALTDDDVAGG
Core:
VTPAISILVSGFISTNTCPSTACTRAC
Core with dehydrations:
VDhbPAIDhaILVDhaGFIDhaDhbNDhbCysPDhaDhbACysDhbRACys

#### antiSMASH-DB 4.0 matches for EI692_RS18435

100.0%
NZ_CP034414.1 and 1 other:
NZ_CP034414.1 Lanthipeptides: EI692_RS18435_lanthipeptide
Lanthipeptides: EI692_RS18435_lanthipeptide
1
VTPAISILVSGFISTNTCPSTACTRAC
27
VTPAISILVSGFISTNTCPSTACTRAC
1
VTPAISILVSGFISTNTCPSTACTRAC
27
67.9%
NZ_CP061868.1 and 1 other:
NZ_CP061868.1 Lanthipeptides: IE339_RS06335_lanthipeptide
Lanthipeptides: IE339_RS06335_lanthipeptide
1
VTPAISIL-VSGFISTNTCPSTACTRAC
27
+TP I I V+G+ISTNTCP+T+CTRAC
1
ITPTIVITAVTGYISTNTCPTTSCTRAC
28
66.7%
NZ_CP016767.1 and 3 others:
NZ_CP016767.1 Lanthipeptides: BCV50_RS13415_lanthipeptide NZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptide NZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptide
Lanthipeptides: BCV50_RS13415_lanthipeptide
2
TPAISILVSGFISTNTCPSTACTRAC
27
TPA+S+ ++G+IS+NTCP+TACTRAC
2
TPALSV-ITGYISSNTCPTTACTRAC
26
with 74 more sequence matches
Only the first 10 are displayed here.
66.7%
NZ_JALAPU010000003.1 and 7 others:
NZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07925_lanthipeptide NZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00585_lanthipeptide NZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00585_lanthipeptide NZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17010_lanthipeptide NZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17010_lanthipeptide NZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04640_lanthipeptide NZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04640_lanthipeptide
Lanthipeptides: MOD17_RS07925_lanthipeptide
2
TPAISILVSGFISTNTCPSTACTRAC
27
TPA+S+ V+ +IS+NTCP+TACTRAC
2
TPALSV-VTAYISSNTCPTTACTRAC
26
66.7%
NZ_NUIO01000031.1 and 1 other:
NZ_NUIO01000031.1 Lanthipeptides: CN977_RS23165_lanthipeptide
Lanthipeptides: CN977_RS23165_lanthipeptide
1
VTPAISIL---VSGFISTNTCPSTACTRAC
27
+TP +SI VSG+IS+NTCP+TACTRAC
1
ITPTVSIALTAVSGYISSNTCPTTACTRAC
30
60.7%
NZ_PCGR01000003.1 and 1 other:
NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09625_lanthipeptide
Lanthipeptides: CQS04_RS09625_lanthipeptide
2
TPAISI-LVSGFISTNTCPSTACTRAC
27
TP I I ++G+IS N+CP+TACTRAC
2
TPTIVITAITGYISANSCPTTACTRAC
28
60.0%
NZ_QGEE01000020.1 and 3 others:
NZ_QGEE01000020.1 Lanthipeptides: DKP74_RS06165_lanthipeptide NZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05385_lanthipeptide NZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05385_lanthipeptide
Lanthipeptides: DKP74_RS06165_lanthipeptide
2
TPAI---SILVSGFISTNTCPSTACTRAC
27
TP I +++VSGF+S++TCP+TACTRAC
2
TPVIGYSAVIVSGFVSSHTCPTTACTRAC
30
59.3%
NZ_KE384533.1 and 2 others:
NZ_KE384533.1 Lanthipeptides: K329_RS31315_lanthipeptide NZ_KE384533.1 Lanthipeptides: K329_RS31315_lanthipeptide
Lanthipeptides: K329_RS31315_lanthipeptide
2
TPAISI-LVSGFISTNTCPSTACTRAC
27
TP I I +VS ++STNTCP+T+CT C
1
TPTIVISVVSAYVSTNTCPTTSCTDEC
27
54.8%
NZ_AP026714.1 and 21 others:
NZ_AP026714.1 Lanthipeptides: PO853_RS06520_lanthipeptide NZ_CP028724.1 Lanthipeptides: C7I31_RS11270_lanthipeptide NZ_CP028724.1 Lanthipeptides: C7I31_RS11270_lanthipeptide NZ_CP092907.1 Lanthipeptides: MK744_RS03990_lanthipeptide NZ_CP092907.1 Lanthipeptides: MK744_RS03990_lanthipeptide NZ_KB944759.1 Lanthipeptides: WOA_RS09815_lanthipeptide NZ_KB944759.1 Lanthipeptides: WOA_RS09815_lanthipeptide NZ_KZ845892.1 Lanthipeptides: EB42_RS00090_lanthipeptide NZ_KZ845892.1 Lanthipeptides: EB42_RS00090_lanthipeptide NZ_KZ845958.1 Lanthipeptides: EB53_RS07695_lanthipeptide NZ_KZ845958.1 Lanthipeptides: EB53_RS07695_lanthipeptide NZ_LR607361.1 Lanthipeptides: FN738_RS03740_lanthipeptide NZ_LR607361.1 Lanthipeptides: FN738_RS03740_lanthipeptide NZ_LR607378.1 Lanthipeptides: FN751_RS00125_lanthipeptide NZ_LR607378.1 Lanthipeptides: FN751_RS00125_lanthipeptide NZ_LSFS01000007.1 Lanthipeptides: AW733_RS07745_lanthipeptide NZ_LSFS01000007.1 Lanthipeptides: AW733_RS07745_lanthipeptide NZ_NGMP01000002.1 Lanthipeptides: A5830_RS04680_lanthipeptide NZ_NGMP01000002.1 Lanthipeptides: A5830_RS04680_lanthipeptide NZ_NGMV01000001.1 Lanthipeptides: A5824_RS07985_lanthipeptide NZ_NGMV01000001.1 Lanthipeptides: A5824_RS07985_lanthipeptide
Lanthipeptides: PO853_RS06520_lanthipeptide
1
VTPAISILVSGFISTNTCPSTACTRAC
27
+T ISI VSG+IS TCP++ CTRAC
5
ITIPISIAVSGWISDKTCPTSVCTRAC
31
53.6%
NZ_CP051884.1 and 3 others:
NZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptide NZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptide NZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptide
Lanthipeptides: HGK68_RS15130_lanthipeptide
8
LVSGFISTNTCPSTACTRAC
27
+VS +IS NTCPS+ACTRAC
9
IVSAWISNNTCPSSACTRAC
28
51.5%
NZ_MIFN01000022.1 and 1 other:
NZ_MIFN01000022.1 Lanthipeptides: BHL26_RS15355_lanthipeptide
Lanthipeptides: BHL26_RS15355_lanthipeptide
9
VSGFISTNTCPSTACTRAC
27
VSG+IS+NTCPSTACTRAC
15
VSGYISSNTCPSTACTRAC
33
50.0%
NZ_CACZYW010000004.1 and 3 others:
NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptide NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide
Lanthipeptides: HUF10_RS02820_lanthipeptide
2
TPAISILV--SGFISTNTCPSTACTRAC
27
TPA ++V S ++S TCP+TACTRAC
5
TPATPVIVAVSAYVSDKTCPTTACTRAC
32
46.2%
NZ_BLIS01000009.1 and 5 others:
NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04825_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptide
Lanthipeptides: GVO03_RS04825_lanthipeptide
2
TPAIS---ILVSGFISTNTCPSTACTRAC
27
TPAI I V+ F+S NTCP++ACTRAC
11
TPAIGKGVIAVTAFVSANTCPTSACTRAC
39

#### MIBiG 4.0 matches for EI692_RS18435

27.0%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
4
AISILVSGFISTNTCPSTACTRAC
27
AI V+ +S CP+T CT C
14
AIQAGVAVGVSAAFCPTTKCTSRC
37
22.2%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
18
CPSTACTRAC
27
CP+T CT C
17
CPTTKCTSKC
26
EI692_RS18440
Leader:
MKNEVNKLQKEEQVTWFEEIVDQEFDDDVFGA
Core:
CSTNTFSLSDYWGNKGGWCTISHECMSWCK
Core with dehydrations:
CysDhaDhbNDhbFDhaLDhaDYWGNKGGWCysDhbIDhaHECysMDhaWCysK

#### antiSMASH-DB 4.0 matches for EI692_RS18440

100.0%
NZ_CP034414.1 and 1 other:
NZ_CP034414.1 Lanthipeptides: EI692_RS18440_lanthipeptide
Lanthipeptides: EI692_RS18440_lanthipeptide
1
CSTNTFSLSDYWGNKGGWCTISHECMSWCK
30
CSTNTFSLSDYWGNKGGWCTISHECMSWCK
1
CSTNTFSLSDYWGNKGGWCTISHECMSWCK
30
90.0%
NZ_CP061868.1 and 1 other:
NZ_CP061868.1 Lanthipeptides: IE339_RS06330_lanthipeptide
Lanthipeptides: IE339_RS06330_lanthipeptide
1
CSTNTFSLSDYWGNKGGWCTISHECMSWCK
30
C+TNTFSLSDYWGNKGGWCT +HECMSWCK
1
CTTNTFSLSDYWGNKGGWCTATHECMSWCK
30
90.0%
NZ_FMPI01000012.1 and 1 other:
NZ_FMPI01000012.1 Lanthipeptides: BJR39_RS08305_lanthipeptide
Lanthipeptides: BJR39_RS08305_lanthipeptide
1
CSTNTFSLSDYWGNKGGWCTISHECMSWCK
30
CSTNTFSLSDYWGN G WCT SHECMSWCK
1
CSTNTFSLSDYWGNNGNWCTASHECMSWCK
30
with 101 more sequence matches
Only the first 10 are displayed here.
86.7%
NZ_CACZYW010000004.1 and 1 other:
NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02825_lanthipeptide
Lanthipeptides: HUF10_RS02825_lanthipeptide
1
CSTNTFSLSDYWGNKGGWCTISHECMSWCK
30
CSTNTFSLSDYWGN G WCT+SHECM+WCK
1
CSTNTFSLSDYWGNNGNWCTLSHECMAWCK
30
86.7%
NZ_CP027862.1 and 1 other:
NZ_CP027862.1 Lanthipeptides: allorf_0097945_0098112_lanthipeptide
Lanthipeptides: allorf_0097945_0098112_lanthipeptide
1
CSTNTFSLSDYWGNKGGWCTISHECMSWCK
30
CSTNTFSLSDYWGN+G WCT++HECMSWCK
1
CSTNTFSLSDYWGNRGYWCTLTHECMSWCK
30
86.7%
NZ_CP051884.1 and 2 others:
NZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptide NZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptide
Lanthipeptides: HGK68_RS15125_lanthipeptide
1
CSTNTFSLSDYWGNKGGWCTISHECMSWCK
30
CSTNTFSLSDYWGN G CTI+HECMSWCK
1
CSTNTFSLSDYWGNNGWLCTITHECMSWCK
30
86.7%
NZ_FNHR01000005.1 and 1 other:
NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05590_lanthipeptide
Lanthipeptides: BLQ37_RS05590_lanthipeptide
1
CSTNTFSLSDYWGNKGGWCTISHECMSWCK
30
CSTNTFSLSDY GN G WCTISHECM+WCK
1
CSTNTFSLSDYMGNNGNWCTISHECMAWCK
30
86.7%
NZ_QGEE01000020.1 and 5 others:
NZ_QGEE01000020.1 Lanthipeptides: DKP74_RS06160_lanthipeptide NZ_QGEF01000018.1 Lanthipeptides: DKP75_RS05595_lanthipeptide NZ_QGEF01000018.1 Lanthipeptides: DKP75_RS05595_lanthipeptide NZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05380_lanthipeptide NZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05380_lanthipeptide
Lanthipeptides: DKP74_RS06160_lanthipeptide
1
CSTNTFSLSDYWGNKGGWCTISHECMSWCK
30
CSTNTFSLSDYWGN+G WCT+SHECM+WCK
1
CSTNTFSLSDYWGNRGNWCTLSHECMAWCK
30
83.3%
NZ_AP026714.1 and 21 others:
NZ_AP026714.1 Lanthipeptides: PO853_RS06515_lanthipeptide NZ_CP028724.1 Lanthipeptides: C7I31_RS11265_lanthipeptide NZ_CP028724.1 Lanthipeptides: C7I31_RS11265_lanthipeptide NZ_CP092907.1 Lanthipeptides: MK744_RS03985_lanthipeptide NZ_CP092907.1 Lanthipeptides: MK744_RS03985_lanthipeptide NZ_KB944759.1 Lanthipeptides: WOA_RS09810_lanthipeptide NZ_KB944759.1 Lanthipeptides: WOA_RS09810_lanthipeptide NZ_KZ845892.1 Lanthipeptides: EB42_RS00085_lanthipeptide NZ_KZ845892.1 Lanthipeptides: EB42_RS00085_lanthipeptide NZ_KZ845958.1 Lanthipeptides: EB53_RS07700_lanthipeptide NZ_KZ845958.1 Lanthipeptides: EB53_RS07700_lanthipeptide NZ_LR607361.1 Lanthipeptides: FN738_RS03735_lanthipeptide NZ_LR607361.1 Lanthipeptides: FN738_RS03735_lanthipeptide NZ_LR607378.1 Lanthipeptides: FN751_RS00120_lanthipeptide NZ_LR607378.1 Lanthipeptides: FN751_RS00120_lanthipeptide NZ_LSFS01000007.1 Lanthipeptides: AW733_RS07750_lanthipeptide NZ_LSFS01000007.1 Lanthipeptides: AW733_RS07750_lanthipeptide NZ_NGMP01000002.1 Lanthipeptides: A5830_RS04675_lanthipeptide NZ_NGMP01000002.1 Lanthipeptides: A5830_RS04675_lanthipeptide NZ_NGMV01000001.1 Lanthipeptides: A5824_RS07990_lanthipeptide NZ_NGMV01000001.1 Lanthipeptides: A5824_RS07990_lanthipeptide
Lanthipeptides: PO853_RS06515_lanthipeptide
1
CSTNTFSLSDYWGNKGGWCTISHECMSWCK
30
C+TNTFSLSDYWGNKG WCT +HECM WCK
1
CTTNTFSLSDYWGNKGNWCTATHECMGWCK
30
83.3%
NZ_BLIS01000009.1 and 7 others:
NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04820_lanthipeptide NZ_LR134317.1 Lanthipeptides: EL136_RS01685_lanthipeptide NZ_LR134317.1 Lanthipeptides: EL136_RS01685_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02620_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02620_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01935_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01935_lanthipeptide
Lanthipeptides: GVO03_RS04820_lanthipeptide
1
CSTNTFSLSDYWGNKGGWCTISHECMSWCK
30
C+TNTFSLSDYWGNKG WCT++HECM+WCK
1
CTTNTFSLSDYWGNKGNWCTLTHECMNWCK
30
83.3%
NZ_CP016767.1 and 11 others:
NZ_CP016767.1 Lanthipeptides: BCV50_RS13410_lanthipeptide NZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15325_lanthipeptide NZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15325_lanthipeptide NZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07920_lanthipeptide NZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07920_lanthipeptide NZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00580_lanthipeptide NZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00580_lanthipeptide NZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17015_lanthipeptide NZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17015_lanthipeptide NZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04645_lanthipeptide NZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04645_lanthipeptide
Lanthipeptides: BCV50_RS13410_lanthipeptide
1
CSTNTFSLSDYWGNKGGWCTISHECMSWC
29
C+TNTFSLSDYWGNKGGWCT+S ECM+WC
1
CTTNTFSLSDYWGNKGGWCTVSKECMAWC
29
83.3%
NZ_MIFN01000022.1 and 1 other:
NZ_MIFN01000022.1 Lanthipeptides: BHL26_RS15350_lanthipeptide
Lanthipeptides: BHL26_RS15350_lanthipeptide
1
CSTNTFSLSDYWGNKGGWCTISHECMSWCK
30
C+TNTFSLSDYWGN G WC++SHECMSWCK
1
CTTNTFSLSDYWGNDGSWCSLSHECMSWCK
30
83.3%
NZ_PCGR01000003.1 and 1 other:
NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09620_lanthipeptide
Lanthipeptides: CQS04_RS09620_lanthipeptide
1
CSTNTFSLSDYWGNKGGWCTISHECMSWCK
30
C+TNTFSLSDYWGN G WCT +HECMSWCK
1
CTTNTFSLSDYWGNNGNWCTATHECMSWCK
30

#### MIBiG 4.0 matches for EI692_RS18440

60.0%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
1
CSTNTFSLSDYWGNKGGWCTISHECMSWCK
30
C+TNTFSLS+ GN GGWCT++ EC C
1
CTTNTFSLSNALGNNGGWCTLTKECQPNCN
30
36.7%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
6
FSLSDYWGNKGGWCTISHECMSWC
29
+++S GNKG +CT++ ECM C
4
YNISCRLGNKGAYCTLTVECMPSC
27
15.4%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
19
CTISHECMSWC
29
CT+S EC C
28
CTLSKECQPNC
38
allorf_3594412_3594594
Leader:
MTSAHQRLKNRSYG
Core:
ISITGEFSISQRKSYIVLPRRDRKAPLCRISMLHRITNFYIVCTCF
Core with dehydrations:
IDhaIDhbGEFDhaIDhaQRKDhaYIVLPRRDRKAPLCysRIDhaMLHRIDhbNFYIVCysDhbCysF

#### antiSMASH-DB 4.0 matches for allorf_3594412_3594594

100.0%
NZ_CP034414.1:
Lanthipeptides: allorf_3594412_3594594_lanthipeptide
1
ISITGEFSISQRKSYIVLPRRDRKAPLCRISMLHRITNFYIVCTCF
46
ISITGEFSISQRKSYIVLPRRDRKAPLCRISMLHRITNFYIVCTCF
1
ISITGEFSISQRKSYIVLPRRDRKAPLCRISMLHRITNFYIVCTCF
46
19.6%
NZ_CP010833.1 and 2 others:
NZ_CP013738.1 Lanthipeptides: allorf_2656180_2656281_lanthipeptide NZ_LIXK01000002.1 Lanthipeptides: allorf_0351346_0351447_lanthipeptide
Lanthipeptides: allorf_5390411_5390512_lanthipeptide
25
APLCRISMLHRITN
38
APL R S+LHR T+
2
APLLRCSLLHRGTD
15
12.1%
NZ_CP114039.1:
Lanthipeptides: allorf_7147535_7147768_lanthipeptide
24
KAPLCRISMLHRITNFYIVCT
44
KA LCR+++L + CT
5
KASLCRVAVLLSGALSWSACT
25

#### MIBiG 4.0 matches for allorf_3594412_3594594

6.5%
BGC0000535.4 (ADJ56352.1):
Lanthipeptide: nisin A
26
PLCRISML
33
P C+ L
9
PGCKTGAL
16

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.33 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.99 out of 26.06
Confidence: medium
Additional weak hits (1):
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.53 out of 32.74
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

EI692_RS18435 - Class II
  Cleavage pHMM score: 0.80
  RODEO score: 0
  Monoisotopic mass: 2550.3 Da
  Molecular weight: 2552.0 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2570.0 Da N = 1
    2588.0 Da N = 2
    2606.0 Da N = 3
    2624.0 Da N = 4
    2642.1 Da N = 5
    2660.1 Da N = 6
EI692_RS18440 - Class II
  Cleavage pHMM score: 2.00
  RODEO score: 0
  Monoisotopic mass: 3286.4 Da
  Molecular weight: 3288.7 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3306.7 Da N = 1
    3324.7 Da N = 2
    3342.7 Da N = 3
    3360.7 Da N = 4
allorf_3594412_3594594 - Class II
  Cleavage pHMM score: -6.40
  RODEO score: 0
  Monoisotopic mass: 5286.9 Da
  Molecular weight: 5290.3 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    5308.3 Da N = 1
    5326.3 Da N = 2
    5344.3 Da N = 3
    5362.4 Da N = 4
    5380.4 Da N = 5
EI692_RS18435 - Class II
  Cleavage pHMM score: 0.80
  RODEO score: 0
  Monoisotopic mass: 2550.3 Da
  Molecular weight: 2552.0 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2570.0 Da N = 1
    2588.0 Da N = 2
    2606.0 Da N = 3
    2624.0 Da N = 4
    2642.1 Da N = 5
    2660.1 Da N = 6
EI692_RS18440 - Class II
  Cleavage pHMM score: 2.00
  RODEO score: 0
  Monoisotopic mass: 3286.4 Da
  Molecular weight: 3288.7 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3306.7 Da N = 1
    3324.7 Da N = 2
    3342.7 Da N = 3
    3360.7 Da N = 4
allorf_3594412_3594594 - Class II
  Cleavage pHMM score: -6.40
  RODEO score: 0
  Monoisotopic mass: 5286.9 Da
  Molecular weight: 5290.3 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    5308.3 Da N = 1
    5326.3 Da N = 2
    5344.3 Da N = 3
    5362.4 Da N = 4
    5380.4 Da N = 5

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
MogR | Repressor of flagellar motility genes

NZ_CP034414.1 - Region 12 - NRP-metallophore,NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,612,611 - 3,664,340 nt. (total: 51,730 nt) Show pHMM detection rules used
NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
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Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxygenase
EI692_RS18635: cytochrome P450

smcogs
  SMCOG1007: cytochrome P450

EI692_RS18670: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acyltransferase
EI692_RS18690: polyketide synthase associated protein papA3

smcogs
  SMCOG1209: polyketide synthase associated protein papA3

Hydrolases: esterase hydrolase
EI692_RS18685: isochorismatase

smcogs
  SMCOG1027: isochorismatase

EI692_RS18710: enterobactin/ferric enterobactin esterase

smcogs
  SMCOG1098: enterobactin/ferric enterobactin esterase

Isomerases: isomerase
EI692_RS18675: isochorismate synthase

smcogs
  SMCOG1018: isochorismate synthase

Ligases: ligase
EI692_RS18680: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRP-metallophore | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000309.5 |  |  | 1.04 | NRPS | bacillibactin | Bacillus subtilis subsp. subtilis str. 168
BGC0001185.5 |  |  | 1.04 | NRPS | bacillibactin | Bacillus velezensis FZB42
BGC0000401.5 |  |  | 1.02 | NRPS | paenibactin | Paenibacillus elgii B69
BGC0000343.5 |  |  | 0.85 | NRPS | enterobactin | Pseudomonas sp. J465
BGC0002075.3 |  |  | 0.85 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0001132.4 |  |  | 0.77 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  |  | 0.76 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002695.2 |  |  | 0.75 | NRPS | bacillibactin, bacillibactin E, bacillibactin F | Bacillus sp. WMMC1349
BGC0001128.4 |  |  | 0.74 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4 |  |  | 0.74 | NRPS | xenematide | Xenorhabdus nematophila AN6/1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000309.5 |  | 0.80 | NRPS | bacillibactin | Bacillus subtilis subsp. subtilis str. 168
BGC0001185.5 |  | 0.80 | NRPS | bacillibactin | Bacillus velezensis FZB42
BGC0000401.5 |  | 0.79 | NRPS | paenibactin | Paenibacillus elgii B69
BGC0000343.5 |  | 0.74 | NRPS | enterobactin | Pseudomonas sp. J465
BGC0002075.3 |  | 0.74 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0001132.4 |  | 0.71 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  | 0.70 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002695.2 |  | 0.70 | NRPS | bacillibactin, bacillibactin E, bacillibactin F | Bacillus sp. WMMC1349
BGC0001128.4 |  | 0.70 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4 |  | 0.70 | NRPS | xenematide | Xenorhabdus nematophila AN6/1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.86 out of 26.06
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.52 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.52 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.00 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.67 out of 26.06
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.72 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.62 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.99 out of 29.38
Confidence: medium
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 27.08 out of 32.74
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.50 out of 29.38
Confidence: medium
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.54 out of 18.46
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.88 out of 29.38
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 25.16 out of 28.19
Confidence: strong
Additional weak hits (12):
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.47 out of 26.85
Confidence: weak
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.29 out of 25.75
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.89 out of 30.25
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.73 out of 30.25
Confidence: weak
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.20 out of 26.85
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.44 out of 32.74
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.88 out of 26.12
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.31 out of 29.38
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 26.18 out of 32.74
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.94 out of 29.38
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 26.21 out of 32.74
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.88 out of 26.06
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 14, location 3612610 - 3664340:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
EI692_RS18680: diOH-Bz
Search NORINE for peptide: strict or relaxed
AMP-binding (31..437): diOH-Bz
nrpys: diOH-Bz

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Small clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Single AA prediction:
    dhb (diOH-Bz)

Stachelhaus prediction details:
  Stachelhaus sequence:
    SKSLYPLSSPGGAVQVGGAQQVFGMAEGLVNYTR
  Nearest Stachelhaus code(s):
    diOH-Bz PLPAQGVVNK (94% 8Å match)
    diOH-Bz or Sal PLPAQGVVNK (91% 8Å match)
  Stachelhaus code match:
    100% (strong)

EI692_RS18690: Gly - Thr
Search NORINE for peptide: strict or relaxed
AMP-binding (464..861): Gly
nrpys: Gly

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    gly (Gly)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FSMTFDISGLELQALVGGETNLYGPTETTIWSTM
  Nearest Stachelhaus code(s):
    Gly DILQLGLIWK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1521..1935): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LSTHFDFSVWEGNQIFGGEVNMYGITETTVHVTY
  Nearest Stachelhaus code(s):
    Thr DFWNIGMVHK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
FuR variant 1 | Ferric Uptake Regulator
FuR variant 2 | Ferric Uptake Regulator
MogR | Repressor of flagellar motility genes
RpoN | Regulator of nitrogen assimilation and virulence
ZuR variant 1 | Zinc-responsive repressor