GCF_023109755.1 - 5 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_JALDUX010000010.1 (Streptococcus mitis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	lanthipeptide-class-ii	1	14,765

NZ_JALDUX010000001.1 (Streptococcus mitis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 7.1	T3PKS	367,487	408,659

NZ_JALDUX010000002.1 (Streptococcus mitis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 8.1	terpene-precursor	256,264	277,139

NZ_JALDUX010000005.1 (Streptococcus mitis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 11.1	RiPP-like	10,103	22,256

NZ_JALDUX010000006.1 (Streptococcus mitis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 12.1	RiPP-like	14,772	34,638

Region	Type	From	To
Region 1.1	lanthipeptide-class-ii	1	14,765
Region 7.1	T3PKS	367,487	408,659
Region 8.1	terpene-precursor	256,264	277,139
Region 11.1	RiPP-like	10,103	22,256
Region 12.1	RiPP-like	14,772	34,638

No secondary metabolite regions were found in these records:: NZ_JALDUX010000011.1 (Streptococcus mitis); NZ_JALDUX010000012.1 (Streptococcus mitis); NZ_JALDUX010000013.1 (Streptococcus mitis); NZ_JALDUX010000014.1 (Streptococcus mitis); NZ_JALDUX010000015.1 (Streptococcus mitis); NZ_JALDUX010000003.1 (Streptococcus mitis); NZ_JALDUX010000004.1 (Streptococcus mitis); NZ_JALDUX010000007.1 (Streptococcus mitis); NZ_JALDUX010000008.1 (Streptococcus mitis); NZ_JALDUX010000009.1 (Streptococcus mitis)

Compact view

NZ_JALDUX010000010.1 - Region 1 - lanthipeptide-class-ii

Download region GenBank file

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Location: 1 - 14,765 nt. (total: 14,765 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

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Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: protease

M1F92_RS09560: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase

M1F92_RS09540: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000500.5	0.59	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000504.5	0.51	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001407.5	0.51	ribosomal	bicereucin	Bacillus cereus SJ1
BGC0000554.4	0.50	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000622.5	0.49	ribosomal	megacin	Bacillus megaterium
BGC0000623.3	0.49	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000502.5	0.48	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0001555.4	0.46	ribosomal	colicin V	Escherichia coli chi7122
BGC0002674.2	0.46	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0001210.5	0.46	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000500.5	0.59	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000504.5	0.51	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001407.5	0.51	ribosomal	bicereucin	Bacillus cereus SJ1
BGC0000554.4	0.50	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000622.5	0.49	ribosomal	megacin	Bacillus megaterium
BGC0000623.3	0.49	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000502.5	0.48	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0001555.4	0.46	ribosomal	colicin V	Escherichia coli chi7122
BGC0002674.2	0.46	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0001210.5	0.46	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for M1F92_RS09540

M1F92_RS09530

Leader:

MTNFNSNEKFCGKSLKSLSADEMSLIYGA

Core:

SDGAEPRWTPTPLILKSAAASSKVCISALVSGIGGLVSYNNDCLG

Core with dehydrations:

DhaDGAEPRWDhbPDhbPLILKDhaAAADhaDhaKVCysIDhaALVDhaGIGGLVDhaYNNDCysLG

antiSMASH-DB 4.0 matches for M1F92_RS09530

100.0%

NZ_JALDUX010000010.1:

Lanthipeptides: M1F92_RS09530_lanthipeptide

SDGAEPRWTPTPLILKSAAASSKVCISALVSGIGGLVSYNNDCLG

95.6%

NC_003028.3and 39 others:

NC_003098.1 Lanthipeptides: SPR_RS08860_lanthipeptideNC_011900.1 Lanthipeptides: SPN23F_RS10045_lanthipeptideNC_012466.1 Lanthipeptides: SPJ_RS09630_lanthipeptideNZ_CFDV01000030.1 Lanthipeptides: AQB43_RS08315_lanthipeptideNZ_CFVJ01000005.1 Lanthipeptides: AP598_RS03270_lanthipeptideNZ_CGGJ01000006.1 Lanthipeptides: AP607_RS03210_lanthipeptideNZ_CHVQ01000007.1 Lanthipeptides: AQF85_RS04280_lanthipeptideNZ_CJZM01000008.1 Lanthipeptides: AEE29_RS04150_lanthipeptideNZ_CLHL01000007.1 Lanthipeptides: AE723_RS05755_lanthipeptideNZ_CMIW01000004.1 Lanthipeptides: AD046_RS04070_lanthipeptideNZ_CP035253.1 Lanthipeptides: EQH27_RS09735_lanthipeptideNZ_CP082820.1 Lanthipeptides: K8B76_RS08860_lanthipeptideNZ_CPRX01000013.1 Lanthipeptides: AEE77_RS05815_lanthipeptideNZ_CPTT01000011.1 Lanthipeptides: AEH42_RS06005_lanthipeptideNZ_CRAW01000006.1 Lanthipeptides: AK725_RS04390_lanthipeptideNZ_CRXO01000010.1 Lanthipeptides: AKU38_RS05255_lanthipeptideNZ_FCRW01000008.1 Lanthipeptides: A1N73_RS07430_lanthipeptideNZ_FDDE01000015.1 Lanthipeptides: A1A23_RS09710_lanthipeptideNZ_FDFR01000008.1 Lanthipeptides: A1O50_RS09315_lanthipeptideNZ_FDGF01000009.1 Lanthipeptides: A0899_RS06590_lanthipeptideNZ_FDQP01000009.1 Lanthipeptides: A1S42_RS08045_lanthipeptideNZ_FECM01000008.1 Lanthipeptides: A1930_RS06470_lanthipeptideNZ_FEEQ01000001.1 Lanthipeptides: A1T31_RS01150_lanthipeptideNZ_FEOS01000003.1 Lanthipeptides: A1178_RS03090_lanthipeptideNZ_FFTU01000009.1 Lanthipeptides: A1K37_RS06340_lanthipeptideNZ_FHRS02000028.1 Lanthipeptides: A1898_RS09825_lanthipeptideNZ_FIXQ01000010.1 Lanthipeptides: AZ721_RS04795_lanthipeptideNZ_FZDX01000018.1 Lanthipeptides: CFW91_RS09485_lanthipeptideNZ_FZEI01000008.1 Lanthipeptides: CFW58_RS06405_lanthipeptideNZ_JACVHZ010000010.1 Lanthipeptides: ICJ99_RS03885_lanthipeptideNZ_JAGFAE010000038.1 Lanthipeptides: J5E60_RS09010_lanthipeptideNZ_LR216014.1 Lanthipeptides: E0F05_RS09380_lanthipeptideNZ_LR216019.1 Lanthipeptides: E0E94_RS09630_lanthipeptideNZ_LR216027.1 Lanthipeptides: E0E81_RS09200_lanthipeptideNZ_LR216049.1 Lanthipeptides: E0E96_RS09535_lanthipeptideNZ_LR216064.1 Lanthipeptides: E0F31_RS09520_lanthipeptideNZ_LR536843.1 Lanthipeptides: E0F34_RS09595_lanthipeptideNZ_NANQ01000003.1 Lanthipeptides: B5K28_RS01930_lanthipeptideNZ_NAOJ01000022.1 Lanthipeptides: B5K31_RS08010_lanthipeptide

Lanthipeptides: SP_RS09790_lanthipeptide

SDGAEPRWTPTPLILKSAAASSKVCISALVSGIGGLVSYNNDCLG

SDGAEPRWTPTP+ILKSAAASSKVCISA VSGIGGLVSYNNDCLG

SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGGLVSYNNDCLG

93.3%

NZ_CP035244.1and 3 others:

NZ_CPPE01000023.1 Lanthipeptides: AD654_RS06870_lanthipeptideNZ_FHJP02000011.1 Lanthipeptides: A1O79_RS07380_lanthipeptideNZ_LR216016.1 Lanthipeptides: E0F10_RS10155_lanthipeptide

Lanthipeptides: EQH36_RS09100_lanthipeptide

SDGAEPRWTPTPLILKSAAASSKVCISALVSGIGGLVSYNNDCLG

SDGAEPRWTPTP+ILKSAAASSK+CISA VSGIGGLVSYNNDCLG

SDGAEPRWTPTPIILKSAAASSKICISAAVSGIGGLVSYNNDCLG

with 23 more sequence matches

Only the first 10 are displayed here.

91.1%

NZ_JAMYJM010000002.1:

Lanthipeptides: NKE69_RS04880_lanthipeptide

SDGAEPRWTPTPLILKSAAASSKVCISALVSGIGGLVSYNNDCLG

SDGAEPRWTPTP ILKSA ASSKVCISA+VSGIGG+VSYNNDCLG

SDGAEPRWTPTPFILKSATASSKVCISAVVSGIGGIVSYNNDCLG

84.4%

NZ_MRXY01000010.1:

Lanthipeptides: BTU63_RS06300_lanthipeptide

SDGAEPRWTPTPLILKSAAASSKVCISALVSGIGGLVSYNNDCLG

SDGAEP WTPTP ILKSAA SSKVCISA++SGIGG+ SYNNDCLG

SDGAEPLWTPTPTILKSAARSSKVCISAIISGIGGIFSYNNDCLG

73.3%

NZ_CMKL01000017.1:

Lanthipeptides: AD734_RS09115_lanthipeptide

SDGAEPRWTPTPLILKSAAASSKVCISALVSGIGG

SDGAEPRWTPTP+ILKSAAASSKVCISA VSGIGG

SDGAEPRWTPTPIILKSAAASSKVCISAAVSGIGG

54.3%

NZ_CP041405.1:

Lanthipeptides: FLT43_RS14400_lanthipeptide

EPRWTPT--PLILKSAAASSKVCISALVSGIGGLVSYNNDCLG

EPR TPT P I + SSKVC+S + S IGG+ S+NNDCLG

EPRATPTIVPAISAAVRTSSKVCLSLVASAIGGIASHNNDCLG

54.3%

NZ_LN884299.1:

Lanthipeptides: BN2762_RS08660_lanthipeptide

EPRWTPTPL--ILKSAAASSKVCISALVSGIGGLVSYNNDCLG

+PR TPT + I++S A SSKVCISA+ S I G+VS N +CLG

DPRATPTIVASIIRSVAQSSKVCISAVGSAISGIVSNNKNCLG

53.3%

NZ_JACSPZ010000014.1:

Lanthipeptides: H9635_RS18390_lanthipeptide

EPRWTPTPLILKSAAASSKVCISALVSGIGGLVSYNNDCLG

EP TP IL +A SSK C+ A +S I GLVSYN DCLG

EPHTTP---ILSAATKSSKKCLGA-ISAISGLVSYNKDCLG

51.1%

NZ_LWAG01000079.1:

Lanthipeptides: A4R27_RS25230_lanthipeptide

EPRWTPTPLILKSAAASS-KVCISALVSGIGGLVSYNNDCLG

+PRWTP ++AA S K+CISA+ S IGG+VSYN +C G

DPRWTPIASAAINSAARSSKICISAVGSAIGGIVSYNKNCAG

48.9%

NZ_CP094446.1:

Lanthipeptides: L3476_RS23825_lanthipeptide

EPRWTPTPLILKSAAASSKVCISALVSGIGGLVSYNNDCLG

EPR TP I+ + SSK CISA+ S I G++S+N DCLG

EPRGTPA-TIVSAVTRSSKPCISAIGSAISGIISHNKDCLG

48.9%

NZ_JACSNF010000005.1and 1 other:

NZ_LMPR01000013.1 Lanthipeptides: ASF99_RS16390_lanthipeptide

Lanthipeptides: KNQ12_RS14665_lanthipeptide

EPRWTPT-PLILKSAAASSKVCISALVSGIGGLVSYNNDCLG

+PRWTP L+ +S S+K CI A S I G+VS+N DCLG

DPRWTPVISLVARSIVKSTKACIGAGASAISGIVSHNKDCLG

46.7%

NZ_CP026035.1:

Lanthipeptides: C2H96_RS00305_lanthipeptide

AEPRWTP-TPLILKSAAASSKVCISALVSGIGGLVSYNNDCLG

A+PRWTP +L + S+++CIS + S I G+VS+N DCLG

ADPRWTPAVSAVLSAVGRSTRLCISGIGSAISGIVSHNKDCLG

MIBiG 4.0 matches for M1F92_RS09530

8.9%

BGC0000582.4 (ADR72962.1):

Linaridin: cypemycin

TPLILKSAAASSKVCI

TP + + S +C+

TPTVAQFVIQGSTICL

M1F92_RS09535

Leader:

MKNDFVIGKSLKELSLEEMQLVYGG

Core:

TDGADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

Core with dehydrations:

DhbDGADPRDhaDhbIICysDhaADhbLDhaFIADhaYLGDhaAQDhbRCysGKDNKKK

antiSMASH-DB 4.0 matches for M1F92_RS09535

100.0%

NC_003028.3and 45 others:

NC_003098.1 Lanthipeptides: SPR_RS08865_lanthipeptideNC_011900.1 Lanthipeptides: SPN23F_RS10050_lanthipeptideNC_012466.1 Lanthipeptides: SPJ_RS09635_lanthipeptideNZ_CFDV01000030.1 Lanthipeptides: AQB43_RS08320_lanthipeptideNZ_CFVJ01000005.1 Lanthipeptides: AP598_RS03265_lanthipeptideNZ_CGGJ01000006.1 Lanthipeptides: AP607_RS03205_lanthipeptideNZ_CHVQ01000007.1 Lanthipeptides: AQF85_RS04285_lanthipeptideNZ_CJZM01000008.1 Lanthipeptides: AEE29_RS04155_lanthipeptideNZ_CLHL01000007.1 Lanthipeptides: AE723_RS05750_lanthipeptideNZ_CMIW01000004.1 Lanthipeptides: AD046_RS04075_lanthipeptideNZ_CMKL01000017.1 Lanthipeptides: AD734_RS09110_lanthipeptideNZ_CP035244.1 Lanthipeptides: EQH36_RS09105_lanthipeptideNZ_CP035253.1 Lanthipeptides: EQH27_RS09740_lanthipeptideNZ_CP082820.1 Lanthipeptides: K8B76_RS08865_lanthipeptideNZ_CPPE01000023.1 Lanthipeptides: AD654_RS06875_lanthipeptideNZ_CPRX01000013.1 Lanthipeptides: AEE77_RS05820_lanthipeptideNZ_CPTT01000011.1 Lanthipeptides: AEH42_RS06000_lanthipeptideNZ_CRAW01000006.1 Lanthipeptides: AK725_RS04395_lanthipeptideNZ_CRXO01000010.1 Lanthipeptides: AKU38_RS05260_lanthipeptideNZ_FCRW01000008.1 Lanthipeptides: A1N73_RS07425_lanthipeptideNZ_FDDE01000015.1 Lanthipeptides: A1A23_RS09705_lanthipeptideNZ_FDFR01000008.1 Lanthipeptides: A1O50_RS09320_lanthipeptideNZ_FDGF01000009.1 Lanthipeptides: A0899_RS06595_lanthipeptideNZ_FDQP01000009.1 Lanthipeptides: A1S42_RS08050_lanthipeptideNZ_FECM01000008.1 Lanthipeptides: A1930_RS06475_lanthipeptideNZ_FEEQ01000001.1 Lanthipeptides: A1T31_RS01145_lanthipeptideNZ_FEOS01000003.1 Lanthipeptides: A1178_RS03085_lanthipeptideNZ_FFTU01000009.1 Lanthipeptides: A1K37_RS06335_lanthipeptideNZ_FHJP02000011.1 Lanthipeptides: A1O79_RS07375_lanthipeptideNZ_FHRS02000028.1 Lanthipeptides: A1898_RS09820_lanthipeptideNZ_FIXQ01000010.1 Lanthipeptides: AZ721_RS04790_lanthipeptideNZ_FZDX01000018.1 Lanthipeptides: CFW91_RS09480_lanthipeptideNZ_FZEI01000008.1 Lanthipeptides: CFW58_RS06410_lanthipeptideNZ_JACVHZ010000010.1 Lanthipeptides: ICJ99_RS03880_lanthipeptideNZ_JAGFAE010000038.1 Lanthipeptides: J5E60_RS09005_lanthipeptideNZ_JALDUX010000010.1 Lanthipeptides: M1F92_RS09535_lanthipeptideNZ_JAMYJM010000002.1 Lanthipeptides: NKE69_RS04885_lanthipeptideNZ_LR216014.1 Lanthipeptides: E0F05_RS09385_lanthipeptideNZ_LR216016.1 Lanthipeptides: E0F10_RS10160_lanthipeptideNZ_LR216019.1 Lanthipeptides: E0E94_RS09635_lanthipeptideNZ_LR216027.1 Lanthipeptides: E0E81_RS09205_lanthipeptideNZ_LR216049.1 Lanthipeptides: E0E96_RS09540_lanthipeptideNZ_LR216064.1 Lanthipeptides: E0F31_RS09525_lanthipeptideNZ_LR536843.1 Lanthipeptides: E0F34_RS09600_lanthipeptideNZ_NANQ01000003.1 Lanthipeptides: B5K28_RS01935_lanthipeptide

Lanthipeptides: SP_RS09795_lanthipeptide

TDGADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

97.3%

NZ_MRXY01000010.1:

Lanthipeptides: BTU63_RS06305_lanthipeptide

TDGADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

TDGADPRS+IICSATLSFIASYLGSAQTRCGKDNKKK

TDGADPRSSIICSATLSFIASYLGSAQTRCGKDNKKK

97.3%

NZ_NAOJ01000022.1:

Lanthipeptides: B5K31_RS08015_lanthipeptide

TDGADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

TDGADPRST ICSATLSFIASYLGSAQTRCGKDNKKK

TDGADPRSTTICSATLSFIASYLGSAQTRCGKDNKKK

with 20 more sequence matches

Only the first 10 are displayed here.

70.3%

NZ_CP026035.1:

Lanthipeptides: C2H96_RS00310_lanthipeptide

ADPRSTIICSATLSFIASYLGSAQTRCGKDNKK

AD RST ICSA +SFIA+YLGSA T CGKDNKK

ADVRSTPICSAGISFIATYLGSAATNCGKDNKK

59.5%

NZ_CP094446.1:

Lanthipeptides: L3476_RS23820_lanthipeptide

DGADP--RSTIICSATLSFIASYLGSAQTRCGKDNKK

DG D RST+IC SFI SYL SA +CGK NKK

DGMDVEVRSTLICGVGASFIGSYLASAAFKCGKKNKK

56.8%

NZ_FNYB01000021.1:

Lanthipeptides: BMZ34_RS24360_lanthipeptide

GADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

G DPR+T SF+ASY+ SAQ RCGKDNK K

GVDPRTTP-SPLLASFVASYIASAQYRCGKDNKGK

56.8%

NZ_JACSNF010000005.1and 1 other:

NZ_LMPR01000013.1 Lanthipeptides: ASF99_RS16385_lanthipeptide

Lanthipeptides: KNQ12_RS14670_lanthipeptide

ADPRSTIICSATLSFIASYLGSAQTRCGKDNKK

D RS+++CSA LSF+ SYL SA +CGKDNKK

VDVRSSLVCSALLSFVGSYLASAGLKCGKDNKK

56.8%

NZ_KB976303.1:

Lanthipeptides: IGY_RS26050_lanthipeptide

GADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

G DPR+T SF+ASY+ SAQ RCGKDNK K

GVDPRTTP-SPLLASFVASYIASAQFRCGKDNKGK

55.3%

NZ_LWAG01000079.1:

Lanthipeptides: A4R27_RS25235_lanthipeptide

ADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

A+ RST+IC A +S I SYL SA +CGKDNK K

AEARSTLICGAGISLIGSYLASAAFKCGKDNKGK

54.1%

NZ_FNYB01000021.1:

Lanthipeptides: BMZ34_RS24355_lanthipeptide

GADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

G DPR+T SF+ASY+ SA+ RCGKDNK K

GVDPRTTP-SPLLASFVASYIASAEFRCGKDNKGK

51.4%

NZ_LN884299.1:

Lanthipeptides: BN2762_RS08665_lanthipeptide

ADPRSTIICSATLSFIASYLGSAQTRCGKDNK

A+ RST++C +SF+ASYL SA +CGKDNK

AEVRSTLLCGMGISFVASYLASAAFKCGKDNK

51.4%

NZ_NVMQ01000017.1:

Lanthipeptides: CON32_RS17790_lanthipeptide

GADPRSTIICSATLSFIASYLGSAQTRCGKDNKKK

G DPR+T SF+ASY+ SA+ +CGKDNK K

GVDPRTTP-SPLLASFVASYIASAEFKCGKDNKGK

48.6%

NZ_KN125582.1:

Lanthipeptides: DJ91_RS27545_lanthipeptide

GADPRSTIICSATLSFIASYLGSAQTRCGKDNK

G PR+T + SF+ASY+ SA+ RCGKDNK

GVTPRTTPATTLLASFVASYIASAEFRCGKDNK

allorf_00832_00984

Leader:

MIIDKNNNAA

Core:

MRFCIFLPFLTSLNNRLLANSKIMTSWAPHSLSFLSGSLN

Core with dehydrations:

MRFCysIFLPFLDhbDhaLNNRLLANDhaKIMDhbDhaWAPHDhaLDhaFLDhaGDhaLN

antiSMASH-DB 4.0 matches for allorf_00832_00984

100.0%

NZ_JALDUX010000010.1:

Lanthipeptides: allorf_00832_00984_lanthipeptide

MRFCIFLPFLTSLNNRLLANSKIMTSWAPHSLSFLSGSLN

MIBiG 4.0 matches for allorf_00832_00984

10.0%

BGC0000503.5 (cinA):

Lanthipeptide: cinnamycin

CIFLPF

C F PF

CSFGPF

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.81 out of 30.25

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.63 out of 27.55

Confidence: medium

Lanthipeptides

TFBS Finder

Core peptide predictions

M1F92_RS09530 - Class II

Cleavage pHMM score: -0.40

RODEO score: 0

Monoisotopic mass: 4355.3 Da

Molecular weight: 4357.9 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 4375.9 Da N = 1; 4394.0 Da N = 2; 4412.0 Da N = 3; 4430.0 Da N = 4; 4448.0 Da N = 5; 4466.0 Da N = 6; 4484.1 Da N = 7

M1F92_RS09535 - Class II

Cleavage pHMM score: -1.30

RODEO score: 0

Monoisotopic mass: 3741.0 Da

Molecular weight: 3743.2 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3761.2 Da N = 1; 3779.2 Da N = 2; 3797.3 Da N = 3; 3815.3 Da N = 4; 3833.3 Da N = 5; 3851.3 Da N = 6; 3869.3 Da N = 7

allorf_00832_00984 - Class II

Cleavage pHMM score: -5.60

RODEO score: 0

Monoisotopic mass: 4364.3 Da

Molecular weight: 4367.1 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 4385.2 Da N = 1; 4403.2 Da N = 2; 4421.2 Da N = 3; 4439.2 Da N = 4; 4457.2 Da N = 5; 4475.3 Da N = 6; 4493.3 Da N = 7; 4511.3 Da N = 8

TFBS definitions

Regulator	Description
ColR	Phenol-responsive regulator
GnfM	Regulator of nitrogen-fixation genes

NZ_JALDUX010000001.1 - Region 1 - T3PKS

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Location: 367,487 - 408,659 nt. (total: 41,173 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: reductase

M1F92_RS01845: hydroxymethylglutaryl-CoA reductase

smcogs: SMCOG1187: hydroxymethylglutaryl-CoA reductase

Transferases: formyltransferase methyltransferase phosphotransferase

M1F92_RS01770: methyltransferase

smcogs: SMCOG1248: methyltransferase

M1F92_RS01810: methionyl-tRNA formyltransferase

smcogs: SMCOG1228: methionyl-tRNA formyltransferase

M1F92_RS01860: Glucose-specific phosphotransferase enzyme IIA

smcogs: SMCOG1145: Glucose-specific phosphotransferase enzyme IIA

Hydrolases: hydrolase

M1F92_RS01760: isochorismatase

smcogs: SMCOG1027: isochorismatase

Ligases: synthase

M1F92_RS01840: hydroxymethylglutaryl-CoA synthase

smcogs: SMCOG1043: hydroxymethylglutaryl-CoA synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001521.3	0.41	NRPS	auriculamide	Herpetosiphon aurantiacus DSM 785
BGC0002561.3	0.40	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0000205.3	0.40	PKS	bryostatin	Candidatus Endobugula sertula
BGC0000706.3	0.39	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0000820.5	0.39	other (other)	physostigmine	Streptomyces griseofuscus
BGC0002690.2	0.37	other (other)	FW0622	Verrucosispora sp. FIM060022
BGC0001080.5	0.37	other (phenazine)	endophenazine A, endophenazine B	Streptomyces anulatus
BGC0002387.2	0.37	PKS	yangpumicin A	Micromonospora yangpuensis
BGC0000286.3	0.36	PKS	viguiepinol	Streptomyces sp. KO-3988
BGC0000019.5	0.36	PKS	angolamycin	Streptomyces eurythermus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001521.3	0.41	NRPS	auriculamide	Herpetosiphon aurantiacus DSM 785
BGC0002561.3	0.40	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0000205.3	0.40	PKS	bryostatin	Candidatus Endobugula sertula
BGC0000706.3	0.39	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0000820.5	0.39	other (other)	physostigmine	Streptomyces griseofuscus
BGC0002690.2	0.37	other (other)	FW0622	Verrucosispora sp. FIM060022
BGC0001080.5	0.37	other (phenazine)	endophenazine A, endophenazine B	Streptomyces anulatus
BGC0002387.2	0.37	PKS	yangpumicin A	Micromonospora yangpuensis
BGC0000286.3	0.36	PKS	viguiepinol	Streptomyces sp. KO-3988
BGC0000019.5	0.36	PKS	angolamycin	Streptomyces eurythermus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.53 out of 20.97

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.40 out of 30.25

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.60 out of 26.06

Confidence: medium

Additional weak hits (5):

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 21.39 out of 30.12

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.73 out of 29.25

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.18 out of 29.25

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.00 out of 30.98

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.97 out of 27.04

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
ColR	Phenol-responsive regulator
MogR	Repressor of flagellar motility genes

NZ_JALDUX010000002.1 - Region 1 - terpene-precursor

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Location: 256,264 - 277,139 nt. (total: 20,876 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: sulfhydrylase

M1F92_RS05990: O-succinylhomoserine sulfhydrylase

smcogs: SMCOG1168: O-succinylhomoserine sulfhydrylase

Hydrolases: back translocase

M1F92_RS06045: GTP-binding protein LepA

smcogs: SMCOG1190: GTP-binding protein LepA

Ligases: synthetase

M1F92_RS06020: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0001605.3	0.35	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0000815.4	0.35	other (other)	loline, N-acetylnorloline, N-formylloline	Epichloe uncinata
BGC0000633.3	0.34	terpene	carotenoid	Streptomyces avermitilis
BGC0001227.3	0.34	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000648.3	0.34	terpene	carotenoid	Myxococcus xanthus
BGC0001456.3	0.33	terpene	isorenieratene	Streptomyces argillaceus
BGC0001529.5	0.32	other (other)	benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K	Streptomyces sp. RI18

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0001605.3	0.35	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0000815.4	0.35	other (other)	loline, N-acetylnorloline, N-formylloline	Epichloe uncinata
BGC0000633.3	0.34	terpene	carotenoid	Streptomyces avermitilis
BGC0001227.3	0.34	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000648.3	0.34	terpene	carotenoid	Myxococcus xanthus
BGC0001456.3	0.33	terpene	isorenieratene	Streptomyces argillaceus
BGC0001529.5	0.32	other (other)	benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K	Streptomyces sp. RI18

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

M1F92_RS06020: PT_FPPS_like

Domain 1 (27 - 272): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 23.59 out of 25.88

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.28 out of 23.79

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.72 out of 27.78

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.77 out of 20.97

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.55 out of 19.26

Confidence: medium

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.83 out of 21.55

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.47 out of 28.19

Confidence: medium

Additional weak hits (3):

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.13 out of 25.88

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.49 out of 33.14

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.19 out of 30.11

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
CRP	Cyclic AMP receptor protein
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
IolR	Regulator of the inositol catabolism
PsrA	Oleic acid responsive regulator
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_JALDUX010000005.1 - Region 1 - RiPP-like

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Location: 10,103 - 22,256 nt. (total: 12,154 nt) Show pHMM detection rules used

Region on contig edge.

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: aminotransferase

M1F92_RS08405: aminotransferase

smcogs: SMCOG1019: aminotransferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002579.2	0.48	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0002577.2	0.46	ribosomal	lactococcin G	Lactococcus lactis
BGC0000617.5	0.45	ribosomal	coagulin	Bacillus coagulans
BGC0000624.3	0.43	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0000558.5	0.42	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0002005.2	0.40	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0000619.3	0.39	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001602.3	0.39	ribosomal	gassericin-T	Lactobacillus gasseri
BGC0001388.3	0.39	ribosomal	gassericin E	Lactobacillus gasseri
BGC0001863.4	0.39	ribosomal, terpene	bacillicn CER074	Bacillus mycoides

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002579.2	0.48	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0002577.2	0.46	ribosomal	lactococcin G	Lactococcus lactis
BGC0000617.5	0.45	ribosomal	coagulin	Bacillus coagulans
BGC0000624.3	0.43	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0000558.5	0.42	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0002005.2	0.40	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0000619.3	0.39	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001602.3	0.39	ribosomal	gassericin-T	Lactobacillus gasseri
BGC0001388.3	0.39	ribosomal	gassericin E	Lactobacillus gasseri
BGC0001863.4	0.39	ribosomal, terpene	bacillicn CER074	Bacillus mycoides

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.35 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.88 out of 26.06

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.90 out of 20.47

Confidence: medium

Additional weak hits (7):

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.05 out of 30.11

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.58 out of 30.25

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.30 out of 39.62

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.84 out of 29.38

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.09 out of 30.25

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 20.85 out of 30.22

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 19.96 out of 24.78

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis
VqsM	Regulator of quorum-sensing signalling systems

NZ_JALDUX010000006.1 - Region 1 - RiPP-like

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Location: 14,772 - 34,638 nt. (total: 19,867 nt) Show pHMM detection rules used

Region on contig edge.

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002577.2	0.56	ribosomal	lactococcin G	Lactococcus lactis
BGC0000619.3	0.53	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001602.3	0.53	ribosomal	gassericin-T	Lactobacillus gasseri
BGC0001388.3	0.53	ribosomal	gassericin E	Lactobacillus gasseri
BGC0002579.2	0.52	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0000617.5	0.51	ribosomal	coagulin	Bacillus coagulans
BGC0000624.3	0.50	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0000558.5	0.42	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0002005.2	0.40	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0001929.2	0.39	ribosomal	WGK	Streptococcus ferus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002577.2	0.56	ribosomal	lactococcin G	Lactococcus lactis
BGC0000619.3	0.53	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001602.3	0.53	ribosomal	gassericin-T	Lactobacillus gasseri
BGC0001388.3	0.53	ribosomal	gassericin E	Lactobacillus gasseri
BGC0002579.2	0.52	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0000617.5	0.51	ribosomal	coagulin	Bacillus coagulans
BGC0000624.3	0.50	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0000558.5	0.42	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0002005.2	0.40	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0001929.2	0.39	ribosomal	WGK	Streptococcus ferus

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.06 out of 19.26

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.02 out of 26.06

Confidence: medium

Additional weak hits (2):

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 19.95 out of 25.88

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 24.63 out of 35.63

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
MogR	Repressor of flagellar motility genes