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Overview
1.1
7.1
8.1
11.1
12.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_JALDUX010000010.1 (Streptococcus mitis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | lanthipeptide-class-ii | 1 | 14,765 |

NZ_JALDUX010000001.1 (Streptococcus mitis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 7.1 | T3PKS | 367,487 | 408,659 |

NZ_JALDUX010000002.1 (Streptococcus mitis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 8.1 | terpene-precursor | 256,264 | 277,139 |

NZ_JALDUX010000005.1 (Streptococcus mitis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 11.1 | RiPP-like | 10,103 | 22,256 |

NZ_JALDUX010000006.1 (Streptococcus mitis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 12.1 | RiPP-like | 14,772 | 34,638 |  |

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | lanthipeptide-class-ii | 1 | 14,765 |
Region 7.1 | T3PKS | 367,487 | 408,659 |
Region 8.1 | terpene-precursor | 256,264 | 277,139 |
Region 11.1 | RiPP-like | 10,103 | 22,256 |
Region 12.1 | RiPP-like | 14,772 | 34,638 |  |

No secondary metabolite regions were found in these records:
  NZ_JALDUX010000011.1 (Streptococcus mitis)
  NZ_JALDUX010000012.1 (Streptococcus mitis)
  NZ_JALDUX010000013.1 (Streptococcus mitis)
  NZ_JALDUX010000014.1 (Streptococcus mitis)
  NZ_JALDUX010000015.1 (Streptococcus mitis)
  NZ_JALDUX010000003.1 (Streptococcus mitis)
  NZ_JALDUX010000004.1 (Streptococcus mitis)
  NZ_JALDUX010000007.1 (Streptococcus mitis)
  NZ_JALDUX010000008.1 (Streptococcus mitis)
  NZ_JALDUX010000009.1 (Streptococcus mitis)

Compact view
NZ_JALDUX010000010.1 - Region 1 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 14,765 nt. (total: 14,765 nt) Show pHMM detection rules used
Region on contig edge.
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
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Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: protease
M1F92_RS09560: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase
M1F92_RS09540: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000500.5 |  | 0.59 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000504.5 |  | 0.51 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0001407.5 |  | 0.51 | ribosomal | bicereucin | Bacillus cereus SJ1
BGC0000554.4 |  | 0.50 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000622.5 |  | 0.49 | ribosomal | megacin | Bacillus megaterium
BGC0000623.3 |  | 0.49 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000502.5 |  | 0.48 | ribosomal | cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7 | Bacillus cereus
BGC0001555.4 |  | 0.46 | ribosomal | colicin V | Escherichia coli chi7122
BGC0002674.2 |  | 0.46 | ribosomal | enterocin F4-9 | Enterococcus faecalis
BGC0001210.5 |  | 0.46 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000500.5 |  | 0.59 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000504.5 |  | 0.51 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0001407.5 |  | 0.51 | ribosomal | bicereucin | Bacillus cereus SJ1
BGC0000554.4 |  | 0.50 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000622.5 |  | 0.49 | ribosomal | megacin | Bacillus megaterium
BGC0000623.3 |  | 0.49 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000502.5 |  | 0.48 | ribosomal | cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7 | Bacillus cereus
BGC0001555.4 |  | 0.46 | ribosomal | colicin V | Escherichia coli chi7122
BGC0002674.2 |  | 0.46 | ribosomal | enterocin F4-9 | Enterococcus faecalis
BGC0001210.5 |  | 0.46 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for M1F92_RS09540

M1F92_RS09530
Leader:
MTNFNSNEKFCGKSLKSLSADEMSLIYGA
Core:
S D G A E P R W T P T P L I L K S A A A S S K V C I S A L V S G I G G L V S Y N N D C L G
Core with dehydrations:
Dha D G A E P R W Dhb P Dhb P L I L K Dha A A A Dha Dha K V Cys I Dha A L V Dha G I G G L V Dha Y N N D Cys L G

#### antiSMASH-DB 4.0 matches for M1F92_RS09530

100.0%
NZ_JALDUX010000010.1:
Lanthipeptides: M1F92_RS09530_lanthipeptide
1
S D G A E P R W T P T P L I L K S A A A S S K V C I S A L V S G I G G L V S Y N N D C L G
45
S D G A E P R W T P T P L I L K S A A A S S K V C I S A L V S G I G G L V S Y N N D C L G
1
S D G A E P R W T P T P L I L K S A A A S S K V C I S A L V S G I G G L V S Y N N D C L G
45
95.6%
NC_003028.3 and 39 others:
NC_003098.1 Lanthipeptides: SPR_RS08860_lanthipeptide NC_011900.1 Lanthipeptides: SPN23F_RS10045_lanthipeptide NC_012466.1 Lanthipeptides: SPJ_RS09630_lanthipeptide NZ_CFDV01000030.1 Lanthipeptides: AQB43_RS08315_lanthipeptide NZ_CFVJ01000005.1 Lanthipeptides: AP598_RS03270_lanthipeptide NZ_CGGJ01000006.1 Lanthipeptides: AP607_RS03210_lanthipeptide NZ_CHVQ01000007.1 Lanthipeptides: AQF85_RS04280_lanthipeptide NZ_CJZM01000008.1 Lanthipeptides: AEE29_RS04150_lanthipeptide NZ_CLHL01000007.1 Lanthipeptides: AE723_RS05755_lanthipeptide NZ_CMIW01000004.1 Lanthipeptides: AD046_RS04070_lanthipeptide NZ_CP035253.1 Lanthipeptides: EQH27_RS09735_lanthipeptide NZ_CP082820.1 Lanthipeptides: K8B76_RS08860_lanthipeptide NZ_CPRX01000013.1 Lanthipeptides: AEE77_RS05815_lanthipeptide NZ_CPTT01000011.1 Lanthipeptides: AEH42_RS06005_lanthipeptide NZ_CRAW01000006.1 Lanthipeptides: AK725_RS04390_lanthipeptide NZ_CRXO01000010.1 Lanthipeptides: AKU38_RS05255_lanthipeptide NZ_FCRW01000008.1 Lanthipeptides: A1N73_RS07430_lanthipeptide NZ_FDDE01000015.1 Lanthipeptides: A1A23_RS09710_lanthipeptide NZ_FDFR01000008.1 Lanthipeptides: A1O50_RS09315_lanthipeptide NZ_FDGF01000009.1 Lanthipeptides: A0899_RS06590_lanthipeptide NZ_FDQP01000009.1 Lanthipeptides: A1S42_RS08045_lanthipeptide NZ_FECM01000008.1 Lanthipeptides: A1930_RS06470_lanthipeptide NZ_FEEQ01000001.1 Lanthipeptides: A1T31_RS01150_lanthipeptide NZ_FEOS01000003.1 Lanthipeptides: A1178_RS03090_lanthipeptide NZ_FFTU01000009.1 Lanthipeptides: A1K37_RS06340_lanthipeptide NZ_FHRS02000028.1 Lanthipeptides: A1898_RS09825_lanthipeptide NZ_FIXQ01000010.1 Lanthipeptides: AZ721_RS04795_lanthipeptide NZ_FZDX01000018.1 Lanthipeptides: CFW91_RS09485_lanthipeptide NZ_FZEI01000008.1 Lanthipeptides: CFW58_RS06405_lanthipeptide NZ_JACVHZ010000010.1 Lanthipeptides: ICJ99_RS03885_lanthipeptide NZ_JAGFAE010000038.1 Lanthipeptides: J5E60_RS09010_lanthipeptide NZ_LR216014.1 Lanthipeptides: E0F05_RS09380_lanthipeptide NZ_LR216019.1 Lanthipeptides: E0E94_RS09630_lanthipeptide NZ_LR216027.1 Lanthipeptides: E0E81_RS09200_lanthipeptide NZ_LR216049.1 Lanthipeptides: E0E96_RS09535_lanthipeptide NZ_LR216064.1 Lanthipeptides: E0F31_RS09520_lanthipeptide NZ_LR536843.1 Lanthipeptides: E0F34_RS09595_lanthipeptide NZ_NANQ01000003.1 Lanthipeptides: B5K28_RS01930_lanthipeptide NZ_NAOJ01000022.1 Lanthipeptides: B5K31_RS08010_lanthipeptide
Lanthipeptides: SP_RS09790_lanthipeptide
1
S D G A E P R W T P T P L I L K S A A A S S K V C I S A L V S G I G G L V S Y N N D C L G
45
S D G A E P R W T P T P+I L K S A A A S S K V C I S A V S G I G G L V S Y N N D C L G
1
S D G A E P R W T P T P I I L K S A A A S S K V C I S A A V S G I G G L V S Y N N D C L G
45
93.3%
NZ_CP035244.1 and 3 others:
NZ_CPPE01000023.1 Lanthipeptides: AD654_RS06870_lanthipeptide NZ_FHJP02000011.1 Lanthipeptides: A1O79_RS07380_lanthipeptide NZ_LR216016.1 Lanthipeptides: E0F10_RS10155_lanthipeptide
Lanthipeptides: EQH36_RS09100_lanthipeptide
1
S D G A E P R W T P T P L I L K S A A A S S K V C I S A L V S G I G G L V S Y N N D C L G
45
S D G A E P R W T P T P+I L K S A A A S S K+C I S A V S G I G G L V S Y N N D C L G
1
S D G A E P R W T P T P I I L K S A A A S S K I C I S A A V S G I G G L V S Y N N D C L G
45
with 23 more sequence matches
Only the first 10 are displayed here.
91.1%
NZ_JAMYJM010000002.1:
Lanthipeptides: NKE69_RS04880_lanthipeptide
1
S D G A E P R W T P T P L I L K S A A A S S K V C I S A L V S G I G G L V S Y N N D C L G
45
S D G A E P R W T P T P I L K S A A S S K V C I S A+V S G I G G+V S Y N N D C L G
1
S D G A E P R W T P T P F I L K S A T A S S K V C I S A V V S G I G G I V S Y N N D C L G
45
84.4%
NZ_MRXY01000010.1:
Lanthipeptides: BTU63_RS06300_lanthipeptide
1
S D G A E P R W T P T P L I L K S A A A S S K V C I S A L V S G I G G L V S Y N N D C L G
45
S D G A E P W T P T P I L K S A A S S K V C I S A++S G I G G+ S Y N N D C L G
1
S D G A E P L W T P T P T I L K S A A R S S K V C I S A I I S G I G G I F S Y N N D C L G
45
73.3%
NZ_CMKL01000017.1:
Lanthipeptides: AD734_RS09115_lanthipeptide
1
S D G A E P R W T P T P L I L K S A A A S S K V C I S A L V S G I G G
35
S D G A E P R W T P T P+I L K S A A A S S K V C I S A V S G I G G
1
S D G A E P R W T P T P I I L K S A A A S S K V C I S A A V S G I G G
35
54.3%
NZ_CP041405.1:
Lanthipeptides: FLT43_RS14400_lanthipeptide
5
E P R W T P T--P L I L K S A A A S S K V C I S A L V S G I G G L V S Y N N D C L G
45
E P R T P T P I + S S K V C+S + S I G G+ S+N N D C L G
4
E P R A T P T I V P A I S A A V R T S S K V C L S L V A S A I G G I A S H N N D C L G
46
54.3%
NZ_LN884299.1:
Lanthipeptides: BN2762_RS08660_lanthipeptide
5
E P R W T P T P L--I L K S A A A S S K V C I S A L V S G I G G L V S Y N N D C L G
45
+P R T P T + I++S A S S K V C I S A+ S I G+V S N +C L G
4
D P R A T P T I V A S I I R S V A Q S S K V C I S A V G S A I S G I V S N N K N C L G
46
53.3%
NZ_JACSPZ010000014.1:
Lanthipeptides: H9635_RS18390_lanthipeptide
5
E P R W T P T P L I L K S A A A S S K V C I S A L V S G I G G L V S Y N N D C L G
45
E P T P I L +A S S K C+ A +S I G L V S Y N D C L G
5
E P H T T P---I L S A A T K S S K K C L G A-I S A I S G L V S Y N K D C L G
41
51.1%
NZ_LWAG01000079.1:
Lanthipeptides: A4R27_RS25230_lanthipeptide
5
E P R W T P T P L I L K S A A A S S-K V C I S A L V S G I G G L V S Y N N D C L G
45
+P R W T P ++A A S K+C I S A+ S I G G+V S Y N +C G
4
D P R W T P I A S A A I N S A A R S S K I C I S A V G S A I G G I V S Y N K N C A G
45
48.9%
NZ_CP094446.1:
Lanthipeptides: L3476_RS23825_lanthipeptide
5
E P R W T P T P L I L K S A A A S S K V C I S A L V S G I G G L V S Y N N D C L G
45
E P R T P I+ + S S K C I S A+ S I G++S+N D C L G
4
E P R G T P A-T I V S A V T R S S K P C I S A I G S A I S G I I S H N K D C L G
43
48.9%
NZ_JACSNF010000005.1 and 1 other:
NZ_LMPR01000013.1 Lanthipeptides: ASF99_RS16390_lanthipeptide
Lanthipeptides: KNQ12_RS14665_lanthipeptide
5
E P R W T P T-P L I L K S A A A S S K V C I S A L V S G I G G L V S Y N N D C L G
45
+P R W T P L+ +S S+K C I A S I G+V S+N D C L G
4
D P R W T P V I S L V A R S I V K S T K A C I G A G A S A I S G I V S H N K D C L G
45
46.7%
NZ_CP026035.1:
Lanthipeptides: C2H96_RS00305_lanthipeptide
4
A E P R W T P-T P L I L K S A A A S S K V C I S A L V S G I G G L V S Y N N D C L G
45
A+P R W T P +L + S+++C I S + S I G+V S+N D C L G
3
A D P R W T P A V S A V L S A V G R S T R L C I S G I G S A I S G I V S H N K D C L G
45

#### MIBiG 4.0 matches for M1F92_RS09530

8.9%
BGC0000582.4 (ADR72962.1):
Linaridin: cypemycin
11
T P L I L K S A A A S S K V C I
26
T P + + S +C+
5
T P T V A Q F V I Q G S T I C L
20
M1F92_RS09535
Leader:
MKNDFVIGKSLKELSLEEMQLVYGG
Core:
T D G A D P R S T I I C S A T L S F I A S Y L G S A Q T R C G K D N K K K
Core with dehydrations:
Dhb D G A D P R Dha Dhb I I Cys Dha A Dhb L Dha F I A Dha Y L G Dha A Q Dhb R Cys G K D N K K K

#### antiSMASH-DB 4.0 matches for M1F92_RS09535

100.0%
NC_003028.3 and 45 others:
NC_003098.1 Lanthipeptides: SPR_RS08865_lanthipeptide NC_011900.1 Lanthipeptides: SPN23F_RS10050_lanthipeptide NC_012466.1 Lanthipeptides: SPJ_RS09635_lanthipeptide NZ_CFDV01000030.1 Lanthipeptides: AQB43_RS08320_lanthipeptide NZ_CFVJ01000005.1 Lanthipeptides: AP598_RS03265_lanthipeptide NZ_CGGJ01000006.1 Lanthipeptides: AP607_RS03205_lanthipeptide NZ_CHVQ01000007.1 Lanthipeptides: AQF85_RS04285_lanthipeptide NZ_CJZM01000008.1 Lanthipeptides: AEE29_RS04155_lanthipeptide NZ_CLHL01000007.1 Lanthipeptides: AE723_RS05750_lanthipeptide NZ_CMIW01000004.1 Lanthipeptides: AD046_RS04075_lanthipeptide NZ_CMKL01000017.1 Lanthipeptides: AD734_RS09110_lanthipeptide NZ_CP035244.1 Lanthipeptides: EQH36_RS09105_lanthipeptide NZ_CP035253.1 Lanthipeptides: EQH27_RS09740_lanthipeptide NZ_CP082820.1 Lanthipeptides: K8B76_RS08865_lanthipeptide NZ_CPPE01000023.1 Lanthipeptides: AD654_RS06875_lanthipeptide NZ_CPRX01000013.1 Lanthipeptides: AEE77_RS05820_lanthipeptide NZ_CPTT01000011.1 Lanthipeptides: AEH42_RS06000_lanthipeptide NZ_CRAW01000006.1 Lanthipeptides: AK725_RS04395_lanthipeptide NZ_CRXO01000010.1 Lanthipeptides: AKU38_RS05260_lanthipeptide NZ_FCRW01000008.1 Lanthipeptides: A1N73_RS07425_lanthipeptide NZ_FDDE01000015.1 Lanthipeptides: A1A23_RS09705_lanthipeptide NZ_FDFR01000008.1 Lanthipeptides: A1O50_RS09320_lanthipeptide NZ_FDGF01000009.1 Lanthipeptides: A0899_RS06595_lanthipeptide NZ_FDQP01000009.1 Lanthipeptides: A1S42_RS08050_lanthipeptide NZ_FECM01000008.1 Lanthipeptides: A1930_RS06475_lanthipeptide NZ_FEEQ01000001.1 Lanthipeptides: A1T31_RS01145_lanthipeptide NZ_FEOS01000003.1 Lanthipeptides: A1178_RS03085_lanthipeptide NZ_FFTU01000009.1 Lanthipeptides: A1K37_RS06335_lanthipeptide NZ_FHJP02000011.1 Lanthipeptides: A1O79_RS07375_lanthipeptide NZ_FHRS02000028.1 Lanthipeptides: A1898_RS09820_lanthipeptide NZ_FIXQ01000010.1 Lanthipeptides: AZ721_RS04790_lanthipeptide NZ_FZDX01000018.1 Lanthipeptides: CFW91_RS09480_lanthipeptide NZ_FZEI01000008.1 Lanthipeptides: CFW58_RS06410_lanthipeptide NZ_JACVHZ010000010.1 Lanthipeptides: ICJ99_RS03880_lanthipeptide NZ_JAGFAE010000038.1 Lanthipeptides: J5E60_RS09005_lanthipeptide NZ_JALDUX010000010.1 Lanthipeptides: M1F92_RS09535_lanthipeptide NZ_JAMYJM010000002.1 Lanthipeptides: NKE69_RS04885_lanthipeptide NZ_LR216014.1 Lanthipeptides: E0F05_RS09385_lanthipeptide NZ_LR216016.1 Lanthipeptides: E0F10_RS10160_lanthipeptide NZ_LR216019.1 Lanthipeptides: E0E94_RS09635_lanthipeptide NZ_LR216027.1 Lanthipeptides: E0E81_RS09205_lanthipeptide NZ_LR216049.1 Lanthipeptides: E0E96_RS09540_lanthipeptide NZ_LR216064.1 Lanthipeptides: E0F31_RS09525_lanthipeptide NZ_LR536843.1 Lanthipeptides: E0F34_RS09600_lanthipeptide NZ_NANQ01000003.1 Lanthipeptides: B5K28_RS01935_lanthipeptide
Lanthipeptides: SP_RS09795_lanthipeptide
1
T D G A D P R S T I I C S A T L S F I A S Y L G S A Q T R C G K D N K K K
37
T D G A D P R S T I I C S A T L S F I A S Y L G S A Q T R C G K D N K K K
1
T D G A D P R S T I I C S A T L S F I A S Y L G S A Q T R C G K D N K K K
37
97.3%
NZ_MRXY01000010.1:
Lanthipeptides: BTU63_RS06305_lanthipeptide
1
T D G A D P R S T I I C S A T L S F I A S Y L G S A Q T R C G K D N K K K
37
T D G A D P R S+I I C S A T L S F I A S Y L G S A Q T R C G K D N K K K
1
T D G A D P R S S I I C S A T L S F I A S Y L G S A Q T R C G K D N K K K
37
97.3%
NZ_NAOJ01000022.1:
Lanthipeptides: B5K31_RS08015_lanthipeptide
1
T D G A D P R S T I I C S A T L S F I A S Y L G S A Q T R C G K D N K K K
37
T D G A D P R S T I C S A T L S F I A S Y L G S A Q T R C G K D N K K K
1
T D G A D P R S T T I C S A T L S F I A S Y L G S A Q T R C G K D N K K K
37
with 20 more sequence matches
Only the first 10 are displayed here.
70.3%
NZ_CP026035.1:
Lanthipeptides: C2H96_RS00310_lanthipeptide
4
A D P R S T I I C S A T L S F I A S Y L G S A Q T R C G K D N K K
36
A D R S T I C S A +S F I A+Y L G S A T C G K D N K K
5
A D V R S T P I C S A G I S F I A T Y L G S A A T N C G K D N K K
37
59.5%
NZ_CP094446.1:
Lanthipeptides: L3476_RS23820_lanthipeptide
2
D G A D P--R S T I I C S A T L S F I A S Y L G S A Q T R C G K D N K K
36
D G D R S T+I C S F I S Y L S A +C G K N K K
1
D G M D V E V R S T L I C G V G A S F I G S Y L A S A A F K C G K K N K K
37
56.8%
NZ_FNYB01000021.1:
Lanthipeptides: BMZ34_RS24360_lanthipeptide
3
G A D P R S T I I C S A T L S F I A S Y L G S A Q T R C G K D N K K K
37
G D P R+T S F+A S Y+ S A Q R C G K D N K K
2
G V D P R T T P-S P L L A S F V A S Y I A S A Q Y R C G K D N K G K
35
56.8%
NZ_JACSNF010000005.1 and 1 other:
NZ_LMPR01000013.1 Lanthipeptides: ASF99_RS16385_lanthipeptide
Lanthipeptides: KNQ12_RS14670_lanthipeptide
4
A D P R S T I I C S A T L S F I A S Y L G S A Q T R C G K D N K K
36
D R S+++C S A L S F+ S Y L S A +C G K D N K K
4
V D V R S S L V C S A L L S F V G S Y L A S A G L K C G K D N K K
36
56.8%
NZ_KB976303.1:
Lanthipeptides: IGY_RS26050_lanthipeptide
3
G A D P R S T I I C S A T L S F I A S Y L G S A Q T R C G K D N K K K
37
G D P R+T S F+A S Y+ S A Q R C G K D N K K
2
G V D P R T T P-S P L L A S F V A S Y I A S A Q F R C G K D N K G K
35
55.3%
NZ_LWAG01000079.1:
Lanthipeptides: A4R27_RS25235_lanthipeptide
4
A D P R S T I I C S A T L S F I A S Y L G S A Q T R C G K D N K K K
37
A+ R S T+I C A +S I S Y L S A +C G K D N K K
5
A E A R S T L I C G A G I S L I G S Y L A S A A F K C G K D N K G K
38
54.1%
NZ_FNYB01000021.1:
Lanthipeptides: BMZ34_RS24355_lanthipeptide
3
G A D P R S T I I C S A T L S F I A S Y L G S A Q T R C G K D N K K K
37
G D P R+T S F+A S Y+ S A+ R C G K D N K K
2
G V D P R T T P-S P L L A S F V A S Y I A S A E F R C G K D N K G K
35
51.4%
NZ_LN884299.1:
Lanthipeptides: BN2762_RS08665_lanthipeptide
4
A D P R S T I I C S A T L S F I A S Y L G S A Q T R C G K D N K
35
A+ R S T++C +S F+A S Y L S A +C G K D N K
5
A E V R S T L L C G M G I S F V A S Y L A S A A F K C G K D N K
36
51.4%
NZ_NVMQ01000017.1:
Lanthipeptides: CON32_RS17790_lanthipeptide
3
G A D P R S T I I C S A T L S F I A S Y L G S A Q T R C G K D N K K K
37
G D P R+T S F+A S Y+ S A+ +C G K D N K K
2
G V D P R T T P-S P L L A S F V A S Y I A S A E F K C G K D N K G K
35
48.6%
NZ_KN125582.1:
Lanthipeptides: DJ91_RS27545_lanthipeptide
3
G A D P R S T I I C S A T L S F I A S Y L G S A Q T R C G K D N K
35
G P R+T + S F+A S Y+ S A+ R C G K D N K
2
G V T P R T T P A T T L L A S F V A S Y I A S A E F R C G K D N K
34
allorf_00832_00984
Leader:
MIIDKNNNAA
Core:
M R F C I F L P F L T S L N N R L L A N S K I M T S W A P H S L S F L S G S L N
Core with dehydrations:
M R F Cys I F L P F L Dhb Dha L N N R L L A N Dha K I M Dhb Dha W A P H Dha L Dha F L Dha G Dha L N

#### antiSMASH-DB 4.0 matches for allorf_00832_00984

100.0%
NZ_JALDUX010000010.1:
Lanthipeptides: allorf_00832_00984_lanthipeptide
1
M R F C I F L P F L T S L N N R L L A N S K I M T S W A P H S L S F L S G S L N
40
M R F C I F L P F L T S L N N R L L A N S K I M T S W A P H S L S F L S G S L N
1
M R F C I F L P F L T S L N N R L L A N S K I M T S W A P H S L S F L S G S L N
40

#### MIBiG 4.0 matches for allorf_00832_00984

10.0%
BGC0000503.5 (cinA):
Lanthipeptide: cinnamycin
4
C I F L P F
9
C F P F
5
C S F G P F
10

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.81 out of 30.25
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.63 out of 27.55
Confidence: medium
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

M1F92_RS09530 - Class II
  Cleavage pHMM score: -0.40
  RODEO score: 0
  Monoisotopic mass: 4355.3 Da
  Molecular weight: 4357.9 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4375.9 Da N = 1
    4394.0 Da N = 2
    4412.0 Da N = 3
    4430.0 Da N = 4
    4448.0 Da N = 5
    4466.0 Da N = 6
    4484.1 Da N = 7
M1F92_RS09535 - Class II
  Cleavage pHMM score: -1.30
  RODEO score: 0
  Monoisotopic mass: 3741.0 Da
  Molecular weight: 3743.2 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3761.2 Da N = 1
    3779.2 Da N = 2
    3797.3 Da N = 3
    3815.3 Da N = 4
    3833.3 Da N = 5
    3851.3 Da N = 6
    3869.3 Da N = 7
allorf_00832_00984 - Class II
  Cleavage pHMM score: -5.60
  RODEO score: 0
  Monoisotopic mass: 4364.3 Da
  Molecular weight: 4367.1 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4385.2 Da N = 1
    4403.2 Da N = 2
    4421.2 Da N = 3
    4439.2 Da N = 4
    4457.2 Da N = 5
    4475.3 Da N = 6
    4493.3 Da N = 7
    4511.3 Da N = 8

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ColR | Phenol-responsive regulator
GnfM | Regulator of nitrogen-fixation genes

NZ_JALDUX010000001.1 - Region 1 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 367,487 - 408,659 nt. (total: 41,173 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: reductase
M1F92_RS01845: hydroxymethylglutaryl-CoA reductase

smcogs
  SMCOG1187: hydroxymethylglutaryl-CoA reductase

Transferases: formyltransferase methyltransferase phosphotransferase
M1F92_RS01770: methyltransferase

smcogs
  SMCOG1248: methyltransferase

M1F92_RS01810: methionyl-tRNA formyltransferase

smcogs
  SMCOG1228: methionyl-tRNA formyltransferase

M1F92_RS01860: Glucose-specific phosphotransferase enzyme IIA

smcogs
  SMCOG1145: Glucose-specific phosphotransferase enzyme IIA

Hydrolases: hydrolase
M1F92_RS01760: isochorismatase

smcogs
  SMCOG1027: isochorismatase

Ligases: synthase
M1F92_RS01840: hydroxymethylglutaryl-CoA synthase

smcogs
  SMCOG1043: hydroxymethylglutaryl-CoA synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001521.3 |  | 0.41 | NRPS | auriculamide | Herpetosiphon aurantiacus DSM 785
BGC0002561.3 |  | 0.40 | other (other) | phenazine SA, phenazine SB, phenazine SC | Streptomyces sp.
BGC0000205.3 |  | 0.40 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0000706.3 |  | 0.39 | saccharide | kanamycin | Streptomyces kanamyceticus
BGC0000820.5 |  | 0.39 | other (other) | physostigmine | Streptomyces griseofuscus
BGC0002690.2 |  | 0.37 | other (other) | FW0622 | Verrucosispora sp. FIM060022
BGC0001080.5 |  | 0.37 | other (phenazine) | endophenazine A, endophenazine B | Streptomyces anulatus
BGC0002387.2 |  | 0.37 | PKS | yangpumicin A | Micromonospora yangpuensis
BGC0000286.3 |  | 0.36 | PKS | viguiepinol | Streptomyces sp. KO-3988
BGC0000019.5 |  | 0.36 | PKS | angolamycin | Streptomyces eurythermus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001521.3 |  | 0.41 | NRPS | auriculamide | Herpetosiphon aurantiacus DSM 785
BGC0002561.3 |  | 0.40 | other (other) | phenazine SA, phenazine SB, phenazine SC | Streptomyces sp.
BGC0000205.3 |  | 0.40 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0000706.3 |  | 0.39 | saccharide | kanamycin | Streptomyces kanamyceticus
BGC0000820.5 |  | 0.39 | other (other) | physostigmine | Streptomyces griseofuscus
BGC0002690.2 |  | 0.37 | other (other) | FW0622 | Verrucosispora sp. FIM060022
BGC0001080.5 |  | 0.37 | other (phenazine) | endophenazine A, endophenazine B | Streptomyces anulatus
BGC0002387.2 |  | 0.37 | PKS | yangpumicin A | Micromonospora yangpuensis
BGC0000286.3 |  | 0.36 | PKS | viguiepinol | Streptomyces sp. KO-3988
BGC0000019.5 |  | 0.36 | PKS | angolamycin | Streptomyces eurythermus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.53 out of 20.97
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.40 out of 30.25
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.60 out of 26.06
Confidence: medium
Additional weak hits (5):
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 21.39 out of 30.12
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.73 out of 29.25
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.18 out of 29.25
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.00 out of 30.98
Confidence: weak
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.97 out of 27.04
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
ColR | Phenol-responsive regulator
MogR | Repressor of flagellar motility genes

NZ_JALDUX010000002.1 - Region 1 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 256,264 - 277,139 nt. (total: 20,876 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: sulfhydrylase
M1F92_RS05990: O-succinylhomoserine sulfhydrylase

smcogs
  SMCOG1168: O-succinylhomoserine sulfhydrylase

Hydrolases: back translocase
M1F92_RS06045: GTP-binding protein LepA

smcogs
  SMCOG1190: GTP-binding protein LepA

Ligases: synthetase
M1F92_RS06020: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0001605.3 |  | 0.35 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0000815.4 |  | 0.35 | other (other) | loline, N-acetylnorloline, N-formylloline | Epichloe uncinata
BGC0000633.3 |  | 0.34 | terpene | carotenoid | Streptomyces avermitilis
BGC0001227.3 |  | 0.34 | terpene | isorenieratene | Streptomyces collinus Tu 365
BGC0000648.3 |  | 0.34 | terpene | carotenoid | Myxococcus xanthus
BGC0001456.3 |  | 0.33 | terpene | isorenieratene | Streptomyces argillaceus
BGC0001529.5 |  | 0.32 | other (other) | benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K | Streptomyces sp. RI18

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0001605.3 |  | 0.35 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0000815.4 |  | 0.35 | other (other) | loline, N-acetylnorloline, N-formylloline | Epichloe uncinata
BGC0000633.3 |  | 0.34 | terpene | carotenoid | Streptomyces avermitilis
BGC0001227.3 |  | 0.34 | terpene | isorenieratene | Streptomyces collinus Tu 365
BGC0000648.3 |  | 0.34 | terpene | carotenoid | Myxococcus xanthus
BGC0001456.3 |  | 0.33 | terpene | isorenieratene | Streptomyces argillaceus
BGC0001529.5 |  | 0.32 | other (other) | benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K | Streptomyces sp. RI18

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
M1F92_RS06020: PT_FPPS_like
Domain 1 (27 - 272): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  DMAPP, IPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 23.59 out of 25.88
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.28 out of 23.79
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.72 out of 27.78
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.77 out of 20.97
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.55 out of 19.26
Confidence: medium
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.83 out of 21.55
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.47 out of 28.19
Confidence: medium
Additional weak hits (3):
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.13 out of 25.88
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.49 out of 33.14
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.19 out of 30.11
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArcA | Repressor of carbon oxidation
CRP | Cyclic AMP receptor protein
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
IolR | Regulator of the inositol catabolism
PsrA | Oleic acid responsive regulator
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_JALDUX010000005.1 - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 10,103 - 22,256 nt. (total: 12,154 nt) Show pHMM detection rules used
Region on contig edge.
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: aminotransferase
M1F92_RS08405: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002579.2 |  | 0.48 | ribosomal | carnobacteriocin XY | Carnobacterium maltaromaticum
BGC0002577.2 |  | 0.46 | ribosomal | lactococcin G | Lactococcus lactis
BGC0000617.5 |  | 0.45 | ribosomal | coagulin | Bacillus coagulans
BGC0000624.3 |  | 0.43 | ribosomal | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0000558.5 |  | 0.42 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0002005.2 |  | 0.40 | ribosomal | RaxX | Xanthomonas oryzae pv. oryzae
BGC0000619.3 |  | 0.39 | ribosomal | gassericin T | Lactobacillus gasseri
BGC0001602.3 |  | 0.39 | ribosomal | gassericin-T | Lactobacillus gasseri
BGC0001388.3 |  | 0.39 | ribosomal | gassericin E | Lactobacillus gasseri
BGC0001863.4 |  | 0.39 | ribosomal, terpene | bacillicn CER074 | Bacillus mycoides

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002579.2 |  | 0.48 | ribosomal | carnobacteriocin XY | Carnobacterium maltaromaticum
BGC0002577.2 |  | 0.46 | ribosomal | lactococcin G | Lactococcus lactis
BGC0000617.5 |  | 0.45 | ribosomal | coagulin | Bacillus coagulans
BGC0000624.3 |  | 0.43 | ribosomal | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0000558.5 |  | 0.42 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0002005.2 |  | 0.40 | ribosomal | RaxX | Xanthomonas oryzae pv. oryzae
BGC0000619.3 |  | 0.39 | ribosomal | gassericin T | Lactobacillus gasseri
BGC0001602.3 |  | 0.39 | ribosomal | gassericin-T | Lactobacillus gasseri
BGC0001388.3 |  | 0.39 | ribosomal | gassericin E | Lactobacillus gasseri
BGC0001863.4 |  | 0.39 | ribosomal, terpene | bacillicn CER074 | Bacillus mycoides

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.35 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.88 out of 26.06
Confidence: medium
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.90 out of 20.47
Confidence: medium
Additional weak hits (7):
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.05 out of 30.11
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.58 out of 30.25
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.30 out of 39.62
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.84 out of 29.38
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.09 out of 30.25
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 20.85 out of 30.22
Confidence: weak
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 19.96 out of 24.78
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis
VqsM | Regulator of quorum-sensing signalling systems

NZ_JALDUX010000006.1 - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 14,772 - 34,638 nt. (total: 19,867 nt) Show pHMM detection rules used
Region on contig edge.
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002577.2 |  | 0.56 | ribosomal | lactococcin G | Lactococcus lactis
BGC0000619.3 |  | 0.53 | ribosomal | gassericin T | Lactobacillus gasseri
BGC0001602.3 |  | 0.53 | ribosomal | gassericin-T | Lactobacillus gasseri
BGC0001388.3 |  | 0.53 | ribosomal | gassericin E | Lactobacillus gasseri
BGC0002579.2 |  | 0.52 | ribosomal | carnobacteriocin XY | Carnobacterium maltaromaticum
BGC0000617.5 |  | 0.51 | ribosomal | coagulin | Bacillus coagulans
BGC0000624.3 |  | 0.50 | ribosomal | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0000558.5 |  | 0.42 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0002005.2 |  | 0.40 | ribosomal | RaxX | Xanthomonas oryzae pv. oryzae
BGC0001929.2 |  | 0.39 | ribosomal | WGK | Streptococcus ferus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002577.2 |  | 0.56 | ribosomal | lactococcin G | Lactococcus lactis
BGC0000619.3 |  | 0.53 | ribosomal | gassericin T | Lactobacillus gasseri
BGC0001602.3 |  | 0.53 | ribosomal | gassericin-T | Lactobacillus gasseri
BGC0001388.3 |  | 0.53 | ribosomal | gassericin E | Lactobacillus gasseri
BGC0002579.2 |  | 0.52 | ribosomal | carnobacteriocin XY | Carnobacterium maltaromaticum
BGC0000617.5 |  | 0.51 | ribosomal | coagulin | Bacillus coagulans
BGC0000624.3 |  | 0.50 | ribosomal | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0000558.5 |  | 0.42 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0002005.2 |  | 0.40 | ribosomal | RaxX | Xanthomonas oryzae pv. oryzae
BGC0001929.2 |  | 0.39 | ribosomal | WGK | Streptococcus ferus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.06 out of 19.26
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.02 out of 26.06
Confidence: medium
Additional weak hits (2):
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 19.95 out of 25.88
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 24.63 out of 35.63
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
MogR | Repressor of flagellar motility genes