GCF_022815605.1 - 9 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_JALGRP010000002.1 (Microbacterium sp. VKM Ac-2923)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 12.1	terpene	181,128	205,301	Low	carotenoid	terpene
Region 12.2	linaridin	494,407	516,990	Low	cypemycin	ribosomal:RiPP:Linaridin

NZ_JALGRP010000022.1 (Microbacterium sp. VKM Ac-2923)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 15.1	RiPP-like	1	10,891

NZ_JALGRP010000004.1 (Microbacterium sp. VKM Ac-2923)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 24.1	T3PKS	1	30,095
Region 24.2	terpene-precursor	178,777	199,838	Low	clifednamide A	NRPS:Type I+PKS

NZ_JALGRP010000005.1 (Microbacterium sp. VKM Ac-2923)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 25.1	terpene-precursor,betalactone	82,781	119,428

NZ_JALGRP010000007.1 (Microbacterium sp. VKM Ac-2923)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 27.1	NRP-metallophore,NRPS	70,307	152,110	Low	cahuitamycin A/cahuitamycin B/cahuitamycin C	NRPS:Type I
Region 27.2	lanthipeptide-class-ii	180,790	206,815

NZ_JALGRP010000008.1 (Microbacterium sp. VKM Ac-2923)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 28.1	NAPAA	104,735	138,679	High	ε-Poly-L-lysine	NRPS:Type I

No secondary metabolite regions were found in these records:: NZ_JALGRP010000001.1 (Microbacterium sp. VKM Ac-2923); NZ_JALGRP010000010.1 (Microbacterium sp. VKM Ac-2923); NZ_JALGRP010000011.1 (Microbacterium sp. VKM Ac-2923); NZ_JALGRP010000012.1 (Microbacterium sp. VKM Ac-2923); NZ_JALGRP010000013.1 (Microbacterium sp. VKM Ac-2923); NZ_JALGRP010000014.1 (Microbacterium sp. VKM Ac-2923); NZ_JALGRP010000015.1 (Microbacterium sp. VKM Ac-2923); NZ_JALGRP010000016.1 (Microbacterium sp. VKM Ac-2923); NZ_JALGRP010000017.1 (Microbacterium sp. VKM Ac-2923); NZ_JALGRP010000018.1 (Microbacterium sp. VKM Ac-2923); NZ_JALGRP010000019.1 (Microbacterium sp. VKM Ac-2923); NZ_JALGRP010000020.1 (Microbacterium sp. VKM Ac-2923); NZ_JALGRP010000021.1 (Microbacterium sp. VKM Ac-2923); NZ_JALGRP010000023.1 (Microbacterium sp. VKM Ac-2923); NZ_JALGRP010000024.1 (Microbacterium sp. VKM Ac-2923); NZ_JALGRP010000025.1 (Microbacterium sp. VKM Ac-2923); NZ_JALGRP010000026.1 (Microbacterium sp. VKM Ac-2923); NZ_JALGRP010000027.1 (Microbacterium sp. VKM Ac-2923); NZ_JALGRP010000028.1 (Microbacterium sp. VKM Ac-2923); NZ_JALGRP010000029.1 (Microbacterium sp. VKM Ac-2923); NZ_JALGRP010000003.1 (Microbacterium sp. VKM Ac-2923); NZ_JALGRP010000006.1 (Microbacterium sp. VKM Ac-2923); NZ_JALGRP010000009.1 (Microbacterium sp. VKM Ac-2923)

Compact view

NZ_JALGRP010000002.1 - Region 1 - terpene

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Location: 181,128 - 205,301 nt. (total: 24,174 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

MT347_RS04095: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

Ligases: synthetase

MT347_RS04085: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000637.3	0.67	terpene	carotenoid	Corynebacterium glutamicum
BGC0000644.3	0.61	terpene	carotenoid	Dietzia sp. CQ4
BGC0000650.3	0.59	terpene	carotenoid	Algoriphagus sp. KK10202C
BGC0000647.3	0.57	terpene	carotenoid	Rhodobacter sphaeroides
BGC0000648.3	0.50	terpene	carotenoid	Myxococcus xanthus
BGC0000636.3	0.49	terpene	carotenoid	Brevibacterium linens
BGC0001456.3	0.48	terpene	isorenieratene	Streptomyces argillaceus
BGC0000643.3	0.44	terpene	carotenoid	Brevundimonas vesicularis
BGC0000634.3	0.44	terpene	carotenoid	Brevundimonas sp. SD212
BGC0000391.5	0.37	NRPS	methylpendolmycin, pendolmycin	Marinactinospora thermotolerans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000637.3	0.67	terpene	carotenoid	Corynebacterium glutamicum
BGC0000644.3	0.61	terpene	carotenoid	Dietzia sp. CQ4
BGC0000650.3	0.59	terpene	carotenoid	Algoriphagus sp. KK10202C
BGC0000647.3	0.57	terpene	carotenoid	Rhodobacter sphaeroides
BGC0000648.3	0.50	terpene	carotenoid	Myxococcus xanthus
BGC0000636.3	0.49	terpene	carotenoid	Brevibacterium linens
BGC0001456.3	0.48	terpene	isorenieratene	Streptomyces argillaceus
BGC0000643.3	0.44	terpene	carotenoid	Brevundimonas vesicularis
BGC0000634.3	0.44	terpene	carotenoid	Brevundimonas sp. SD212
BGC0000391.5	0.37	NRPS	methylpendolmycin, pendolmycin	Marinactinospora thermotolerans

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
tetraterpene	C40 carotenoid		C40	unknown	unknown

Genes with terpene domains:

MT347_RS04085: PT_FPPS_like

Domain 1 (47 - 351): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

MT347_RS04090: PT_phytoene_like

Domain 1 (23 - 203): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → PSPP; FPP → squalene; FPP → diapophytoene; GGPP → phytoene; PSPP → hydroxysqualene

MT347_RS04100: Lycopene_cycl

Domain 1 (4 - 93): Lycopene cyclase

Reactions:: C40_carotenoid → C40_carotenoid

MT347_RS04105: Lycopene_cycl

Domain 1 (2 - 91): Lycopene cyclase

Reactions:: C40_carotenoid → C40_carotenoid

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (4):

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.55 out of 27.78

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.69 out of 20.97

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 17.93 out of 29.25

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.47 out of 26.33

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description

NZ_JALGRP010000002.1 - Region 2 - linaridin

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Location: 494,407 - 516,990 nt. (total: 22,584 nt) Show pHMM detection rules used

linaridin: (cypemycin or cypI)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002319.3	0.66	ribosomal	salinipeptin A, salinipeptin B, salinipeptin C, salinipeptin D	Streptomyces sp.
BGC0000583.5	0.64	ribosomal	grisemycin	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000582.4	0.62	ribosomal	cypemycin	Streptomyces sp. OH-4156
BGC0001188.3	0.41	ribosomal	legonaridin	Streptomyces sp. CT34
BGC0000543.5	0.39	ribosomal	pep5	Staphylococcus epidermidis
BGC0001735.5	0.35	other (other)	pentostatine, vidarabine	Streptomyces antibioticus
BGC0002362.3	0.28	PKS	loseolamycin A1, loseolamycin A2	Micromonospora endolithica
BGC0000374.5	0.25	NRPS	hormaomycin, hormaomycin A1, hormaomycin A2, hormaomycin A3, hormaomycin A4, hormaomycin A5, hormaomycin A6	Streptomyces griseoflavus
BGC0001020.5	0.21	NRPS, PKS	muraymycin C1	Streptomyces sp. NRRL 30471

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002319.3	0.66	ribosomal	salinipeptin A, salinipeptin B, salinipeptin C, salinipeptin D	Streptomyces sp.
BGC0000583.5	0.64	ribosomal	grisemycin	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000582.4	0.62	ribosomal	cypemycin	Streptomyces sp. OH-4156
BGC0001188.3	0.41	ribosomal	legonaridin	Streptomyces sp. CT34
BGC0000543.5	0.39	ribosomal	pep5	Staphylococcus epidermidis
BGC0001735.5	0.35	other (other)	pentostatine, vidarabine	Streptomyces antibioticus
BGC0002362.3	0.28	PKS	loseolamycin A1, loseolamycin A2	Micromonospora endolithica
BGC0000374.5	0.25	NRPS	hormaomycin, hormaomycin A1, hormaomycin A2, hormaomycin A3, hormaomycin A4, hormaomycin A5, hormaomycin A6	Streptomyces griseoflavus
BGC0001020.5	0.21	NRPS, PKS	muraymycin C1	Streptomyces sp. NRRL 30471

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.43 out of 20.97

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.78 out of 24.78

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.50 out of 20.47

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.89 out of 18.16

Confidence: strong

Additional weak hits (5):

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.94 out of 23.43

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 23.05 out of 29.65

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.91 out of 20.01

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 19.07 out of 29.25

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.33 out of 27.04

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CcpA	Catabolite control protein A
LexA variant 2	Repressor of DNA damage response
VqsM	Regulator of quorum-sensing signalling systems

NZ_JALGRP010000022.1 - Region 1 - RiPP-like

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Location: 1 - 10,891 nt. (total: 10,891 nt) Show pHMM detection rules used

Region on contig edge.

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002115.3	0.53	ribosomal	streptamidine	Streptomyces albidoflavus J1074
BGC0001638.4	0.51	ribosomal	klebsazolicin	Klebsiella pneumoniae subsp. ozaenae
BGC0000501.3	0.48	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000551.5	0.43	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000513.3	0.42	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000519.4	0.42	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0001639.3	0.41	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0002698.2	0.40	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000569.5	0.37	ribosomal	plantazolicin	Bacillus velezensis FZB42

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002115.3	0.53	ribosomal	streptamidine	Streptomyces albidoflavus J1074
BGC0001638.4	0.51	ribosomal	klebsazolicin	Klebsiella pneumoniae subsp. ozaenae
BGC0000501.3	0.48	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000551.5	0.43	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000513.3	0.42	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000519.4	0.42	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0001639.3	0.41	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0002698.2	0.40	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000569.5	0.37	ribosomal	plantazolicin	Bacillus velezensis FZB42

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.68 out of 29.38

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.92 out of 20.47

Confidence: medium

Additional weak hits (8):

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 16.13 out of 29.25

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.77 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.11 out of 32.74

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 15.78 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 16.44 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.79 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.10 out of 28.14

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.52 out of 28.19

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
FuR variant 1	Ferric Uptake Regulator
VqsM	Regulator of quorum-sensing signalling systems

NZ_JALGRP010000004.1 - Region 1 - T3PKS

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Location: 1 - 30,095 nt. (total: 30,095 nt) Show pHMM detection rules used

Region on contig edge.

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase oxygenase

MT347_RS07855: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

MT347_RS07910: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

Transferases: acetyltransferase glycosyltransferase

MT347_RS07795: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

MT347_RS07830: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

Hydrolases: glucosidase

MT347_RS07860: Alpha-glucosidase

smcogs: SMCOG1257: Alpha-glucosidase

MT347_RS07885: Alpha-glucosidase

smcogs: SMCOG1257: Alpha-glucosidase

Ligases: synthase

MT347_RS07845: chalcone and stilbene synthase domain protein

smcogs: SMCOG1024: chalcone and stilbene synthase domain protein

Translocases: transporter

MT347_RS07880: sugar-binding lipoprotein

smcogs: SMCOG1143: sugar-binding lipoprotein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000282.3	0.54	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001962.3	0.51	PKS	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0002403.2	0.49	PKS	β-Diketones	Hordeum vulgare subsp. vulgare
BGC0001077.4	0.47	PKS	6-anteisoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-geranyl-2-methoxyhydroquinone, 6-palmityl-4-O-geranyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-palmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone	Actinoplanes missouriensis 431
BGC0002285.2	0.46	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0002332.2	0.45	PKS	4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A	Candidatus Entotheonella sp.
BGC0001831.3	0.45	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0002362.3	0.45	PKS	loseolamycin A1, loseolamycin A2	Micromonospora endolithica
BGC0002690.2	0.43	other (other)	FW0622	Verrucosispora sp. FIM060022
BGC0001810.3	0.42	PKS	trehangelin	Polymorphospora rubra

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000282.3	0.54	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001962.3	0.51	PKS	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0002403.2	0.49	PKS	β-Diketones	Hordeum vulgare subsp. vulgare
BGC0001077.4	0.47	PKS	6-anteisoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-geranyl-2-methoxyhydroquinone, 6-palmityl-4-O-geranyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-palmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone	Actinoplanes missouriensis 431
BGC0002285.2	0.46	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0002332.2	0.45	PKS	4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A	Candidatus Entotheonella sp.
BGC0001831.3	0.45	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0002362.3	0.45	PKS	loseolamycin A1, loseolamycin A2	Micromonospora endolithica
BGC0002690.2	0.43	other (other)	FW0622	Verrucosispora sp. FIM060022
BGC0001810.3	0.42	PKS	trehangelin	Polymorphospora rubra

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 26.64 out of 30.11

Confidence: medium

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 25.16 out of 30.11

Confidence: medium

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 18.42 out of 19.52

Confidence: strong

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.46 out of 23.05

Confidence: medium

Additional weak hits (7):

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.06 out of 27.78

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 17.55 out of 29.25

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 20.42 out of 33.73

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.48 out of 21.55

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 19.34 out of 35.63

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 21.90 out of 30.11

Confidence: weak

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 20.71 out of 27.18

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
AfsR	Pleiotropic regulatory for antibiotic production
CelR	Cellobiose uptake repressor

NZ_JALGRP010000004.1 - Region 2 - terpene-precursor

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Location: 178,777 - 199,838 nt. (total: 21,062 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidase

MT347_RS08760: pyruvate oxidase/decarboxylase

smcogs: SMCOG1055: pyruvate oxidase/decarboxylase

Transferases: methyltransferase

MT347_RS08740: methyltransferase

smcogs: SMCOG1089: methyltransferase

Lyases: hydratase

MT347_RS08785: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Isomerases: isomerase

MT347_RS08750: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: ligase synthetase

MT347_RS08735: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

MT347_RS08780: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Translocases: transporter

MT347_RS08720: sugar-binding lipoprotein

smcogs: SMCOG1143: sugar-binding lipoprotein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001641.4	0.56	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000913.3	0.46	other (other)	MK-8	Enterobacter cloacae
BGC0001553.5	0.45	NRPS, PKS	clifednamide A	Streptomyces sp. JV178
BGC0001529.5	0.44	other (other)	benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K	Streptomyces sp. RI18
BGC0001137.5	0.41	other (other)	marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D	Marinactinospora thermotolerans
BGC0000451.5	0.40	NRPS	turnerbactin	Teredinibacter turnerae T7901
BGC0002538.3	0.39	PKS	chaetolivacine A, chaetolivacine B, chaetolivacine C	Chaetomium olivaceum
BGC0000905.5	0.39	other (other)	heme D1	Heliobacillus mobilis
BGC0000906.3	0.39	other (other)	heme D1	Heliophilum fasciatum
BGC0001594.3	0.38	other (other)	fischerindole L	Fischerella muscicola UTEX 1829

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001641.4	0.56	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000913.3	0.46	other (other)	MK-8	Enterobacter cloacae
BGC0001553.5	0.45	NRPS, PKS	clifednamide A	Streptomyces sp. JV178
BGC0001529.5	0.44	other (other)	benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K	Streptomyces sp. RI18
BGC0001137.5	0.41	other (other)	marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D	Marinactinospora thermotolerans
BGC0000451.5	0.40	NRPS	turnerbactin	Teredinibacter turnerae T7901
BGC0002538.3	0.39	PKS	chaetolivacine A, chaetolivacine B, chaetolivacine C	Chaetomium olivaceum
BGC0000905.5	0.39	other (other)	heme D1	Heliobacillus mobilis
BGC0000906.3	0.39	other (other)	heme D1	Heliophilum fasciatum
BGC0001594.3	0.38	other (other)	fischerindole L	Fischerella muscicola UTEX 1829

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

MT347_RS08735: PT_FPPS_like

Domain 1 (61 - 351): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.13 out of 19.26

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 18.49 out of 25.31

Confidence: medium

Additional weak hits (2):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.68 out of 30.22

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.86 out of 19.52

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
CatR	H2O2-responsive repressor

NZ_JALGRP010000005.1 - Region 1 - betalactone,terpene-precursor

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Location: 82,781 - 119,428 nt. (total: 36,648 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)
betalactone: (HMGL-like and AMP-binding)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

MT347_RS10150: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Transferases: acyltransferase

MT347_RS10095: acyltransferase

smcogs: SMCOG1141: acyltransferase

Hydrolases: deformylase

MT347_RS10110: peptide deformylase

smcogs: SMCOG1275: peptide deformylase

Ligases: ligase synthase synthetase

MT347_RS10070: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

MT347_RS10105: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

MT347_RS10120: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000677.5	0.30	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0002309.2	0.30	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0001910.4	0.27	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0001911.3	0.26	terpene	raimonol	Streptomyces anulatus
BGC0000664.5	0.26	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001456.3	0.26	terpene	isorenieratene	Streptomyces argillaceus
BGC0002561.3	0.25	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0000633.3	0.25	terpene	carotenoid	Streptomyces avermitilis
BGC0000649.3	0.25	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000936.5	0.25	other (other)	pyocyanine	Pseudomonas aeruginosa PAO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002309.2	0.47	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000677.5	0.45	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0000649.3	0.43	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001911.3	0.43	terpene	raimonol	Streptomyces anulatus
BGC0001910.4	0.43	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0000664.5	0.43	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002561.3	0.42	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0001456.3	0.42	terpene	isorenieratene	Streptomyces argillaceus
BGC0000633.3	0.42	terpene	carotenoid	Streptomyces avermitilis
BGC0001227.3	0.42	terpene	isorenieratene	Streptomyces collinus Tu 365

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

MT347_RS10070: PT_FPPS_like

Domain 1 (43 - 354): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (6):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.44 out of 30.22

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.38 out of 21.84

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.50 out of 30.22

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 19.59 out of 33.73

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.61 out of 30.22

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.28 out of 26.85

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description

NZ_JALGRP010000007.1 - Region 1 - NRP-metallophore,NRPS

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Location: 70,307 - 152,110 nt. (total: 81,804 nt) Show pHMM detection rules used

NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase oxygenase

MT347_RS12680: lysine/ornithine N-monooxygenase

smcogs: SMCOG1080: lysine/ornithine N-monooxygenase

MT347_RS12755: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

MT347_RS12765: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

Transferases: PPTase formyltransferase methyltransferase

MT347_RS12625: methyltransferase

smcogs: SMCOG1089: methyltransferase

MT347_RS12700: methionyl-tRNA formyltransferase

smcogs: SMCOG1228: methionyl-tRNA formyltransferase

MT347_RS12720: methionyl-tRNA formyltransferase

smcogs: SMCOG1228: methionyl-tRNA formyltransferase

MT347_RS18420: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1060: 4'-phosphopantetheinyl transferase

Hydrolases: hydrolase

MT347_RS12740: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

Ligases: ligase

MT347_RS12695: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

MT347_RS12725: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

MT347_RS12730: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001135.5	0.86	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002135.2	0.85	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001261.3	0.83	NRPS	AM-toxin	Alternaria alternata
BGC0001128.4	0.82	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.82	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002286.3	0.82	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.81	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001132.4	0.80	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.79	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001240.4	0.78	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001135.5	0.74	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002135.2	0.74	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001261.3	0.73	NRPS	AM-toxin	Alternaria alternata
BGC0001128.4	0.73	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.73	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002286.3	0.72	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.72	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001132.4	0.72	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.72	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001240.4	0.71	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.65 out of 18.46

Confidence: strong

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 28.19 out of 36.53

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 31.19 out of 36.53

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.46 out of 23.79

Confidence: medium

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.82 out of 21.84

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.92 out of 20.47

Confidence: medium

Additional weak hits (31):

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 18.12 out of 26.12

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.02 out of 26.06

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.28 out of 27.78

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.33 out of 29.38

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.63 out of 39.62

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 21.50 out of 32.74

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 21.17 out of 32.74

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.10 out of 29.38

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.07 out of 39.62

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.58 out of 29.38

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.95 out of 27.78

Confidence: weak

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 20.86 out of 27.18

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 17.80 out of 33.14

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 25.27 out of 36.53

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 36.53

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.24 out of 36.53

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 15.85 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 17.69 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.86 out of 28.14

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 21.41 out of 36.53

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.49 out of 39.62

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.64 out of 21.84

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 21.05 out of 32.74

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 19.12 out of 35.63

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.49 out of 29.65

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.49 out of 29.65

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 19.14 out of 22.40

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.19 out of 29.65

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.95 out of 29.65

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 21.59 out of 35.63

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.23 out of 30.98

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 70306 - 152110:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Fo-OH-Orn - X) + (Ser - D-Ser - X - X - X - D-Orn)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

MT347_RS12695: diOH-Bz

Search NORINE for peptide: strict or relaxed

AMP-binding (37..443): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: SVSVHSMSVPGGSIHVGGAQQGFGMAEGLVNYVR
Nearest Stachelhaus code(s):: diOH-Bz PMPSGGVVNK (74% 8Å match)
Stachelhaus code match:: 70% (weak)

MT347_RS12725: Fo-OH-Orn - X

Search NORINE for peptide: strict or relaxed

AMP-binding (25..428): Fo-OH-Orn

nrpys: Fo-OH-Orn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: Orn and hydroxy-Orn specific (Orn, OH-Orn)
Single AA prediction:: orn (Orn)

Stachelhaus prediction details:

Stachelhaus sequence:: RWQAFDISINELYLWCGGEYHGYGPAEATIGVSH
Nearest Stachelhaus code(s):: Fo-OH-Orn DINYWGGIGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1095..1519): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: RWGSFVDAATEGLTVTSGEHNFYGSTEITGDATV
Nearest Stachelhaus code(s):: bAla VDTVVSFGDK (68% 8Å match)
Stachelhaus code match:: 90% (moderate)

MT347_RS12730: Ser - Ser - X - X - X - Orn

Search NORINE for peptide: strict or relaxed

AMP-binding (467..880): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWATFDASLWEVHFFVSGEDNVYGPTETTVDVTS
Nearest Stachelhaus code(s):: Ser DVWHFSLVDK (74% 8Å match)
Stachelhaus code match:: 80% (moderate)

AMP-binding (1555..1961): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWMTFDVSVWELHFFFSGEHNLYGPTEAAVDVTA
Nearest Stachelhaus code(s):: Ser DVWHFSLVDK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3107..3511): X

nrpys: Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LWRTFDVSVPEWELSVGGEWNTYGPTEAAVETTG
Nearest Stachelhaus code(s):: meSer DVFESGGVAK (65% 8Å match); Lys DVFESGGVAK (62% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (4173..4583): X

nrpys: Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LWRTFDVAVPEWELSVGGEWNTYGPTEAAVETTG
Nearest Stachelhaus code(s):: meSer DVFESGGVAK (62% 8Å match); Lys DVFESGGVAK (59% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (5247..5656): X

nrpys: Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LWRTFDVSVPEWELSVGGEWNTYGPTEAAVETTG
Nearest Stachelhaus code(s):: meSer DVFESGGVAK (65% 8Å match); Lys DVFESGGVAK (62% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (7134..7552): Orn

nrpys: Orn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: Orn and hydroxy-Orn specific (Orn, OH-Orn)
Single AA prediction:: orn (Orn)

Stachelhaus prediction details:

Stachelhaus sequence:: MNHTFDASWEQWDVSLGGEYNLYGPTEYTINALG
Nearest Stachelhaus code(s):: OH-Orn DMENLGLINK (82% 8Å match)
Stachelhaus code match:: 70% (weak)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
DmdR1	Iron(II)-dependent repressor
IolR	Regulator of the inositol catabolism
MexT	Global virulence regulator
RpoN	Regulator of nitrogen assimilation and virulence
VqsM	Regulator of quorum-sensing signalling systems

NZ_JALGRP010000007.1 - Region 2 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 180,790 - 206,815 nt. (total: 26,026 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidase oxidoreductase

MT347_RS12930: NADH:flavin oxidoreductase/NADH oxidase

smcogs: SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

MT347_RS12935: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

MT347_RS18425: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

Lyases: cyclase

MT347_RS12960: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

MT347_RS12970: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001229.4	0.61	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000517.4	0.60	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0002110.3	0.55	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000528.5	0.55	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001311.5	0.52	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0002005.2	0.51	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0002663.2	0.51	ribosomal	amyloliquecidin GF610	Bacillus amyloliquefaciens UMAF6639
BGC0000554.4	0.51	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001579.4	0.50	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0001210.5	0.50	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001229.4	0.61	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000517.4	0.60	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0002110.3	0.55	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000528.5	0.55	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001311.5	0.52	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0002005.2	0.51	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0002663.2	0.51	ribosomal	amyloliquecidin GF610	Bacillus amyloliquefaciens UMAF6639
BGC0000554.4	0.51	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001579.4	0.50	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0001210.5	0.50	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for MT347_RS12960

MT347_RS12955

Leader:

MTERNVSLLEEIAEQDQALTS

Core:

AGQGWTTTITSLTCYGVSWVAGNNGQVCTATVECQNNCN

Core with dehydrations:

AGQGWDhbDhbDhbIDhbDhaLDhbCysYGVDhaWVAGNNGQVCysDhbADhbVECysQNNCysN

antiSMASH-DB 4.0 matches for MT347_RS12955

100.0%

NZ_JALGRP010000007.1and 1 other:

NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12955_lanthipeptide

Lanthipeptides: MT347_RS12955_lanthipeptide

1

AGQGWTTTITSLTCYGVSWVAGNNGQVCTATVECQNNCN

39

AGQGWTTTITSLTCYGVSWVAGNNGQVCTATVECQNNCN

1

AGQGWTTTITSLTCYGVSWVAGNNGQVCTATVECQNNCN

39

66.7%

NZ_BMRY01000003.1and 24 others:

NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12370_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS18205_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide

Lanthipeptides: IE140_RS12370_lanthipeptide

2

GQGWTTTITSLTCYGVSWVAGNNGQVCTATVECQNNC

38

GQGW T ++SL+CYG S+V GNNG CTAT ECQNNC

1

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNC

37

66.7%

NZ_CP116355.1and 1 other:

NZ_CP116355.1 Lanthipeptides: KPP03845_RS17815_lanthipeptide

Lanthipeptides: KPP03845_RS17815_lanthipeptide

2

GQGWTTTITSLTCYGVSWVAGNNGQVCTATVECQNNC

38

GQGW T ++SL+CYG S+V GNNG CTAT ECQNNC

1

GQGWGTVMSSLSCYGASYVLGNNGNFCTATAECQNNC

37

with 97 more sequence matches

Only the first 10 are displayed here.

66.7%

NZ_WHOM01000078.1and 1 other:

NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29300_lanthipeptide

Lanthipeptides: GCN81_RS29300_lanthipeptide

2

GQGWTTTITSLTCYGVSWVAGNNGQVCTATVECQNNC

38

GQGW TT++SL+CYG S+V GNNG CTAT ECQ+NC

1

GQGWGTTLSSLSCYGASYVLGNNGNFCTATAECQSNC

37

64.1%

NZ_QKTG01000020.1and 1 other:

NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS16920_lanthipeptide

Lanthipeptides: DEI99_RS16920_lanthipeptide

3

QGWTTTITSLTCYGVSWVAGNNGQVCTATVECQNNCN

39

QG TT+T+L+CYGVSW GN+G CTATVECQ+NC

1

QGIGTTVTTLSCYGVSWALGNDGNFCTATVECQSNCK

37

53.8%

NZ_LT575476.1and 1 other:

NZ_LT575476.1 Lanthipeptides: BN6628_RS02285_lanthipeptide

Lanthipeptides: BN6628_RS02285_lanthipeptide

5

WTTTITSLTCYGVSWVAGNNGQVCTATVECQNNCN

39

W T +T+L C G S+ G+ GQVCTATVEC NNC

3

WGTVLTTLACLGASYALGDKGQVCTATVECINNCR

37

52.5%

NZ_JALIRS010000003.1and 3 others:

NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07255_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide

Lanthipeptides: MOK21_RS07255_lanthipeptide

3

QGWTTTI-TSLTCYGVSWVAGNNGQVCTATVECQNNCN

39

+ W TI TSL C S++ GN G VCT TVECQ CN

3

ERWAETILTSLACAAASYILGNPGHVCTLTVECQKKCN

40

51.3%

NZ_CM000756.1and 7 others:

NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS34475_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptide

Lanthipeptides: BTHUR0011_RS34475_lanthipeptide

5

WTTTITSLTCYGVSWVAGNNGQVCTATVECQNNC

38

W TT TS T +S GN G+VCT TVEC NNC

4

WNTTATS-TSIIISETFGNKGKVCTYTVECVNNC

36

51.3%

NZ_CP017953.1and 27 others:

NZ_CP017953.1 Lanthipeptides: BAMY_RS16400_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06480_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06480_lanthipeptideNZ_CP033054.1 Lanthipeptides: D9777_RS18850_lanthipeptideNZ_CP033054.1 Lanthipeptides: D9777_RS18850_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15900_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15900_lanthipeptideNZ_CP047268.1 Lanthipeptides: GKS41_RS18615_lanthipeptideNZ_CP047268.1 Lanthipeptides: GKS41_RS18615_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05705_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05705_lanthipeptideNZ_CP072563.1 Lanthipeptides: J6600_RS15945_lanthipeptideNZ_CP072563.1 Lanthipeptides: J6600_RS15945_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16190_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16190_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16160_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16160_lanthipeptideNZ_CP116014.1 Lanthipeptides: PF996_RS17895_lanthipeptideNZ_CP116014.1 Lanthipeptides: PF996_RS17895_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11815_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11815_lanthipeptideNZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12550_lanthipeptideNZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12550_lanthipeptideNZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01375_lanthipeptideNZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01375_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06825_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06825_lanthipeptide

Lanthipeptides: BAMY_RS16400_lanthipeptide

5

WTTTITSLTCYGVSWVAGNNGQVCTATVECQNNC

38

W TT TSL VS V GN G+VCT T ECQ C

4

WNTTTTSLGGILVSEVLGNKGKVCTGTKECQGTC

37

51.3%

NZ_JAQFWW010000002.1and 1 other:

NZ_JAQFWW010000002.1 Lanthipeptides: PDT38_RS11330_lanthipeptide

Lanthipeptides: PDT38_RS11330_lanthipeptide

5

WTTTITSLTCYGVSWVAGNNGQVCTATVECQNNCN

39

W T +T+L+C S + G+ GQVCT TVECQNNC

3

WGTLLTTLSCLAASIMIGDKGQVCTGTVECQNNCR

37

48.7%

NZ_CP013862.1and 1 other:

NZ_CP013862.1 Lanthipeptides: AOX59_RS09360_lanthipeptide

Lanthipeptides: AOX59_RS09360_lanthipeptide

7

TTITSLTCYGVSWVAGNNGQVCTATVECQNNCN

39

T +T TC+ +S GN+G +CTATVECQ NCN

6

TALTYSTCHWISPAMGNDGHLCTATVECQPNCN

38

48.7%

NZ_CP047645.1and 7 others:

NZ_CP047645.1 Lanthipeptides: GSN02_RS17445_lanthipeptideNZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04860_lanthipeptideNZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04860_lanthipeptideNZ_NJRE01000008.1 Lanthipeptides: CE047_RS18560_lanthipeptideNZ_NJRE01000008.1 Lanthipeptides: CE047_RS18560_lanthipeptideNZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03725_lanthipeptideNZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03725_lanthipeptide

Lanthipeptides: GSN02_RS17445_lanthipeptide

5

WTTTITSLTCYGVSWVAGNNGQVCTATVECQNNC

38

W TT TS+ VS V GN G+VCT T ECQ C

4

WNTTTTSVGTILVSEVFGNKGKVCTGTKECQGTC

37

48.7%

NZ_JAGKQT010000007.1and 3 others:

NZ_JAGKQT010000007.1 Lanthipeptides: J2M30_RS09860_lanthipeptideNZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptideNZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptide

Lanthipeptides: J2M30_RS09860_lanthipeptide

8

TITSLTCYGVSWVAGNNGQVCTATVECQNNC

38

TI++ TC VS GN+G+VCT TVEC NNC

5

TISTSTCIAVSHFVGNDGKVCTYTVECVNNC

35

MIBiG 4.0 matches for MT347_RS12955

35.9%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

15

YGVSWVAGNNGQVCTATVECQNNCN

39

+ +S GNNG CT T ECQ NCN

6

FSLSNALGNNGGWCTLTKECQPNCN

30

33.3%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

15

YGVSWVAGNNGQVCTATVECQNNCN

39

Y +S GN G CT TVEC +CN

4

YNISCRLGNKGAYCTLTVECMPSCN

28

20.5%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

28

CTATVECQNNCN

39

CT + ECQ NCN

28

CTLSKECQPNCN

39

MT347_RS12965

Leader:

MTTNTHNRTGFIAEDDLVLLSENAQDVSAG

Core:

TTTAPCAVAGLTIAATAALPGFCPTGACTTRCTQG

Core with dehydrations:

DhbDhbDhbAPCysAVAGLDhbIAADhbAALPGFCysPDhbGACysDhbDhbRCysDhbQG

antiSMASH-DB 4.0 matches for MT347_RS12965

100.0%

NZ_JALGRP010000007.1and 1 other:

NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12965_lanthipeptide

Lanthipeptides: MT347_RS12965_lanthipeptide

1

TTTAPCAVAGLTIAATAALPGFCPTGACTTRCTQG

35

TTTAPCAVAGLTIAATAALPGFCPTGACTTRCTQG

1

TTTAPCAVAGLTIAATAALPGFCPTGACTTRCTQG

35

68.6%

NZ_JACSPO010000013.1and 1 other:

NZ_JACSPO010000013.1 Lanthipeptides: H9624_RS14885_lanthipeptide

Lanthipeptides: H9624_RS14885_lanthipeptide

1

TTTAPCAVAGLTIAATAALPGFCPTGACTTRC

32

TTT PCA+ G IA +AALP FCPTGACTTRC

3

TTTVPCAIGGGVIAISAALPDFCPTGACTTRC

34

45.7%

NZ_CP017762.1and 3 others:

NZ_CP017762.1 Lanthipeptides: BKP57_RS21840_lanthipeptideNZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptideNZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptide

Lanthipeptides: BKP57_RS21840_lanthipeptide

1

TTTAPCAVAGLTIAATAALPGFCPTGACTTRCTQ

34

TTT PCAVA +IA CPT AC+++C +

1

TTTVPCAVAA-SIA-------LCPTLACSSKCGE

26

with 87 more sequence matches

Only the first 10 are displayed here.

45.7%

NZ_JAENHN010000066.1and 1 other:

NZ_JAENHN010000066.1 Lanthipeptides: JHL18_RS24400_lanthipeptide

Lanthipeptides: JHL18_RS24400_lanthipeptide

5

PCAV---AGLTIAATAALPGFCPTGACTTRC

32

PCAV GLTI A+ C TGACT C

4

PCAVIATVGLTIKVATAV--VCETGACTGYC

32

42.9%

NZ_NTSF01000026.1and 1 other:

NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21840_lanthipeptide

Lanthipeptides: CN325_RS21840_lanthipeptide

1

TTTAPCAVAGLTIAATAALPGFCPTGACTTRC

32

+TT PC + G TI + A +CPT CT RC

2

STTVPCGI-GSTITISIA---YCPTSKCTERC

29

40.0%

NC_015215.1and 5 others:

NC_015215.1 Lanthipeptides: SGGBAA2069_RS00700_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09790_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09790_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05355_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05355_lanthipeptide

Lanthipeptides: SGGBAA2069_RS00700_lanthipeptide

6

CAVAGLT-IAATAALPGFCPTGACTTRCTQ

34

CA A ++ I+ +AL F T ACTTRC

5

CAWAAVSAISTVSAL--FQITTACTTRCYH

32

40.0%

NZ_CM000721.1and 9 others:

NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide

Lanthipeptides: BCERE0010_RS29355_lanthipeptide

8

VAGLTIAATAALPGFCPTGACTTRC

32

+ G TIA TA+L CPT CT+RC

14

IIGATIAVTASL---CPTTKCTSRC

35

40.0%

NZ_CP040938.1and 1 other:

NZ_CP040938.1 Lanthipeptides: B5772_RS02455_lanthipeptide

Lanthipeptides: B5772_RS02455_lanthipeptide

1

TTTAPCAVAGLTIAATAALPGFCPTGACTTRC

32

TT+ PCAV +A+TA CPT C+ +C

2

TTSIPCAV----MASTA----ICPTLVCSNKC

25

40.0%

NZ_JABBGE010000004.1and 1 other:

NZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13570_lanthipeptide

Lanthipeptides: HHL19_RS13570_lanthipeptide

2

TTAPCAVAGLTIAATAALPGFCPTGACTTRC

32

TT CAV +T AT CPT CT++C

1

TTWSCAV--VTAVATLVSASACPTTKCTSQC

29

40.0%

NZ_JAENHN010000066.1and 1 other:

NZ_JAENHN010000066.1 Lanthipeptides: JHL18_RS24410_lanthipeptide

Lanthipeptides: JHL18_RS24410_lanthipeptide

1

TTTAPCAVAGLTIAATAALPGFCPTGACTTRC

32

TTT CA+ GLT+ + CP+ ACT C

2

TTTLACAITGLTVIVVTEVA--CPSKACTGYC

31

40.0%

NZ_QKTG01000020.1and 1 other:

NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS08060_lanthipeptide

Lanthipeptides: DEI99_RS08060_lanthipeptide

16

TAALPGFCPTGACTTRC

32

+AALPGFCPTGACT++C

1

SAALPGFCPTGACTSKC

17

40.0%

NZ_QORY01000016.1and 1 other:

NZ_QORY01000016.1 Lanthipeptides: DT250_RS18265_lanthipeptide

Lanthipeptides: DT250_RS18265_lanthipeptide

2

TTAPCAVAGLTIAATAALPGFCPTGACTTRC

32

TT CA+ TIA+ A CPT AC+++C

8

TTWGCAI--FTIASAAQ----CPTTACSSKC

32

38.1%

NZ_NTSR01000029.1and 1 other:

NZ_NTSR01000029.1 Lanthipeptides: CN358_RS25165_lanthipeptide

Lanthipeptides: CN358_RS25165_lanthipeptide

2

TTAPCAV----AGLTIAATAALPGFCPTGACTTRC

32

TT PCAV G+TI CPT AC++RC

7

TTVPCAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

MIBiG 4.0 matches for MT347_RS12965

32.4%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

9

AGLTIAATAALPGFCPTGACTTRC

32

AG+ + +AA FCPT CT+RC

17

AGVAVGVSAA---FCPTTKCTSRC

37

20.0%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

22

FCPTGACTTRC

32

FCPT CT++C

16

FCPTTKCTSKC

26

20.0%

BGC0002130.3 (QKI29070.1):

Lanthipeptide: cacaoidin

2

TTAPCAV---AGLTIAATAAL

19

++APC + +I+ATA+

1

SSAPCTIYASVSASISATASW

21

allorf_190248_190481

Leader:

MGTARASRGAAPAPTGPRVRLTAAHVGGRRTGVRGA

Core:

ARPLFAATAHVSLRPTRAPPKGQTDVADRRCRRCGPQWKRS

Core with dehydrations:

ARPLFAADhbAHVDhaLRPDhbRAPPKGQDhbDVADRRCysRRCysGPQWKRDha

antiSMASH-DB 4.0 matches for allorf_190248_190481

100.0%

NZ_JALGRP010000007.1and 1 other:

NZ_JALGRP010000007.1 Lanthipeptides: allorf_190248_190481_lanthipeptide

Lanthipeptides: allorf_190248_190481_lanthipeptide

1

ARPLFAATAHVSLRPTRAPPKGQTDVADRRCRRCGPQWKRS

41

ARPLFAATAHVSLRPTRAPPKGQTDVADRRCRRCGPQWKRS

1

ARPLFAATAHVSLRPTRAPPKGQTDVADRRCRRCGPQWKRS

41

19.5%

NZ_CP039292.1and 1 other:

NZ_CP039292.1 Lanthipeptides: allorf_0076338_0076511_lanthipeptide

Lanthipeptides: allorf_0076338_0076511_lanthipeptide

21

KGQTDVADRRCRRCGPQWKRS

41

+G V+D C+ CGP +K +

6

EGSGRVSDCLCKGCGPTYKET

26

allorf_190392_190544

Leader:

MGTLRCGERRPRPRRSSVSGA

Core:

SGTFPLGAAASTPTIGHIRLALRRCTCGP

Core with dehydrations:

DhaGDhbFPLGAAADhaDhbPDhbIGHIRLALRRCysDhbCysGP

antiSMASH-DB 4.0 matches for allorf_190392_190544

100.0%

NZ_JALGRP010000007.1and 1 other:

NZ_JALGRP010000007.1 Lanthipeptides: allorf_190392_190544_lanthipeptide

Lanthipeptides: allorf_190392_190544_lanthipeptide

1

SGTFPLGAAASTPTIGHIRLALRRCTCGP

29

SGTFPLGAAASTPTIGHIRLALRRCTCGP

1

SGTFPLGAAASTPTIGHIRLALRRCTCGP

29

23.4%

NZ_BNBI01000017.1:

Lanthipeptides: allorf_050255_050446_lanthipeptide

5

PLGAAASTPTIGHIRLALRRCTCGP

29

P GAAA TP+ + L+R C P

1

PQGAAARTPS--RVHFGLQRPVCLP

23

20.7%

NZ_LMSL01000013.1:

Lanthipeptides: allorf_11540_11626_lanthipeptide

20

LALRRCTCGP

29

L++R C CGP

4

LSIRLCNCGP

13

with 1 more sequence matches

14.0%

NZ_AZVD01000036.1and 1 other:

NZ_KB898432.1 Lanthipeptides: allorf_07386_07619_lanthipeptide

Lanthipeptides: allorf_19664_19897_lanthipeptide

8

AAASTPTIGHIR

19

A S+P +GH+R

17

ALPSSPHLGHLR

28

allorf_201135_201245

Leader:

MEGERMPGV

Core:

SASAPLSCRAARRAPGGHCLRSGDAPI

Core with dehydrations:

DhaADhaAPLDhaCysRAARRAPGGHCysLRDhaGDAPI

antiSMASH-DB 4.0 matches for allorf_201135_201245

100.0%

NZ_JALGRP010000007.1and 1 other:

NZ_JALGRP010000007.1 Lanthipeptides: allorf_201135_201245_lanthipeptide

Lanthipeptides: allorf_201135_201245_lanthipeptide

1

SASAPLSCRAARRAPGGHCLRSGDAPI

27

SASAPLSCRAARRAPGGHCLRSGDAPI

1

SASAPLSCRAARRAPGGHCLRSGDAPI

27

35.7%

NZ_CP011130.1and 4 others:

NZ_CP023465.1 Lanthipeptides: CNO08_RS25790_lanthipeptideNZ_CP076103.1 Lanthipeptides: KME82_RS10615_lanthipeptideNZ_CP094357.1 Lanthipeptides: IEQ11_RS10290_lanthipeptideNZ_KQ061217.1 Lanthipeptides: WN54_RS27350_lanthipeptide

Lanthipeptides: LC55x_RS27745_lanthipeptide

1

SASAPLSCRAARRAPGGHCLRSGDAPI

27

S S+ C + + GG CL SG+ I

1

STSSFAGCNCSTSSNGG-CLCSGEVTI

26

31.2%

NZ_MUXN01000027.1:

Lanthipeptides: allorf_018463_018597_lanthipeptide

12

RRAPGGHCLRSG-DAPI

27

RRAP G R G DAP+

2

RRAPAGRSRRCGDDAPV

18

with 4 more sequence matches

25.7%

NZ_LMEQ01000012.1:

Lanthipeptides: allorf_0979470_0979679_lanthipeptide

6

LSCRAARRAPGGHCLRSGDAPI

27

L+CR R H RS D P+

5

LACRGEVRPQLVHRERSPDRPV

26

20.5%

NZ_VXKQ01000008.1:

Lanthipeptides: F3D62_RS12715_lanthipeptide

9

RAARRAPGGHCLRSGD

24

A APGGHC + D

20

NATLTAPGGHCTETTD

35

13.5%

NZ_CP007597.1:

Lanthipeptides: allorf_2301019_2301156_lanthipeptide

16

GGHCLR

21

GGHC+R

23

GGHCIR

28

10.4%

NZ_CP086102.1and 1 other:

NZ_KZ195572.1 Lanthipeptides: allorf_6130947_6131129_lanthipeptide

Lanthipeptides: allorf_6120061_6120243_lanthipeptide

19

CLRSGDAP

26

C+R+G+AP

10

CIRTGEAP

17

MIBiG 4.0 matches for allorf_201135_201245

9.8%

BGC0002120.3 (NQE92413.1):

Lanthipeptide: nocathioamide A

14

APGGHCLRS

22

AP H L S

37

APACHTLSS

45

Lanthipeptide(s) for MT347_RS12970

MT347_RS12955

Leader:

MTERNVSLLEEIAEQDQALTS

Core:

AGQGWTTTITSLTCYGVSWVAGNNGQVCTATVECQNNCN

Core with dehydrations:

AGQGWDhbDhbDhbIDhbDhaLDhbCysYGVDhaWVAGNNGQVCysDhbADhbVECysQNNCysN

antiSMASH-DB 4.0 matches for MT347_RS12955

100.0%

NZ_JALGRP010000007.1and 1 other:

NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12955_lanthipeptide

Lanthipeptides: MT347_RS12955_lanthipeptide

1

AGQGWTTTITSLTCYGVSWVAGNNGQVCTATVECQNNCN

39

AGQGWTTTITSLTCYGVSWVAGNNGQVCTATVECQNNCN

1

AGQGWTTTITSLTCYGVSWVAGNNGQVCTATVECQNNCN

39

66.7%

NZ_BMRY01000003.1and 24 others:

NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12370_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS18205_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide

Lanthipeptides: IE140_RS12370_lanthipeptide

2

GQGWTTTITSLTCYGVSWVAGNNGQVCTATVECQNNC

38

GQGW T ++SL+CYG S+V GNNG CTAT ECQNNC

1

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNC

37

66.7%

NZ_CP116355.1and 1 other:

NZ_CP116355.1 Lanthipeptides: KPP03845_RS17815_lanthipeptide

Lanthipeptides: KPP03845_RS17815_lanthipeptide

2

GQGWTTTITSLTCYGVSWVAGNNGQVCTATVECQNNC

38

GQGW T ++SL+CYG S+V GNNG CTAT ECQNNC

1

GQGWGTVMSSLSCYGASYVLGNNGNFCTATAECQNNC

37

with 97 more sequence matches

Only the first 10 are displayed here.

66.7%

NZ_WHOM01000078.1and 1 other:

NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29300_lanthipeptide

Lanthipeptides: GCN81_RS29300_lanthipeptide

2

GQGWTTTITSLTCYGVSWVAGNNGQVCTATVECQNNC

38

GQGW TT++SL+CYG S+V GNNG CTAT ECQ+NC

1

GQGWGTTLSSLSCYGASYVLGNNGNFCTATAECQSNC

37

64.1%

NZ_QKTG01000020.1and 1 other:

NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS16920_lanthipeptide

Lanthipeptides: DEI99_RS16920_lanthipeptide

3

QGWTTTITSLTCYGVSWVAGNNGQVCTATVECQNNCN

39

QG TT+T+L+CYGVSW GN+G CTATVECQ+NC

1

QGIGTTVTTLSCYGVSWALGNDGNFCTATVECQSNCK

37

53.8%

NZ_LT575476.1and 1 other:

NZ_LT575476.1 Lanthipeptides: BN6628_RS02285_lanthipeptide

Lanthipeptides: BN6628_RS02285_lanthipeptide

5

WTTTITSLTCYGVSWVAGNNGQVCTATVECQNNCN

39

W T +T+L C G S+ G+ GQVCTATVEC NNC

3

WGTVLTTLACLGASYALGDKGQVCTATVECINNCR

37

52.5%

NZ_JALIRS010000003.1and 3 others:

NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07255_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide

Lanthipeptides: MOK21_RS07255_lanthipeptide

3

QGWTTTI-TSLTCYGVSWVAGNNGQVCTATVECQNNCN

39

+ W TI TSL C S++ GN G VCT TVECQ CN

3

ERWAETILTSLACAAASYILGNPGHVCTLTVECQKKCN

40

51.3%

NZ_CM000756.1and 7 others:

NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS34475_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptide

Lanthipeptides: BTHUR0011_RS34475_lanthipeptide

5

WTTTITSLTCYGVSWVAGNNGQVCTATVECQNNC

38

W TT TS T +S GN G+VCT TVEC NNC

4

WNTTATS-TSIIISETFGNKGKVCTYTVECVNNC

36

51.3%

NZ_CP017953.1and 27 others:

NZ_CP017953.1 Lanthipeptides: BAMY_RS16400_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06480_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06480_lanthipeptideNZ_CP033054.1 Lanthipeptides: D9777_RS18850_lanthipeptideNZ_CP033054.1 Lanthipeptides: D9777_RS18850_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15900_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15900_lanthipeptideNZ_CP047268.1 Lanthipeptides: GKS41_RS18615_lanthipeptideNZ_CP047268.1 Lanthipeptides: GKS41_RS18615_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05705_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05705_lanthipeptideNZ_CP072563.1 Lanthipeptides: J6600_RS15945_lanthipeptideNZ_CP072563.1 Lanthipeptides: J6600_RS15945_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16190_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16190_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16160_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16160_lanthipeptideNZ_CP116014.1 Lanthipeptides: PF996_RS17895_lanthipeptideNZ_CP116014.1 Lanthipeptides: PF996_RS17895_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11815_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11815_lanthipeptideNZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12550_lanthipeptideNZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12550_lanthipeptideNZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01375_lanthipeptideNZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01375_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06825_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06825_lanthipeptide

Lanthipeptides: BAMY_RS16400_lanthipeptide

5

WTTTITSLTCYGVSWVAGNNGQVCTATVECQNNC

38

W TT TSL VS V GN G+VCT T ECQ C

4

WNTTTTSLGGILVSEVLGNKGKVCTGTKECQGTC

37

51.3%

NZ_JAQFWW010000002.1and 1 other:

NZ_JAQFWW010000002.1 Lanthipeptides: PDT38_RS11330_lanthipeptide

Lanthipeptides: PDT38_RS11330_lanthipeptide

5

WTTTITSLTCYGVSWVAGNNGQVCTATVECQNNCN

39

W T +T+L+C S + G+ GQVCT TVECQNNC

3

WGTLLTTLSCLAASIMIGDKGQVCTGTVECQNNCR

37

48.7%

NZ_CP013862.1and 1 other:

NZ_CP013862.1 Lanthipeptides: AOX59_RS09360_lanthipeptide

Lanthipeptides: AOX59_RS09360_lanthipeptide

7

TTITSLTCYGVSWVAGNNGQVCTATVECQNNCN

39

T +T TC+ +S GN+G +CTATVECQ NCN

6

TALTYSTCHWISPAMGNDGHLCTATVECQPNCN

38

48.7%

NZ_CP047645.1and 7 others:

NZ_CP047645.1 Lanthipeptides: GSN02_RS17445_lanthipeptideNZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04860_lanthipeptideNZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04860_lanthipeptideNZ_NJRE01000008.1 Lanthipeptides: CE047_RS18560_lanthipeptideNZ_NJRE01000008.1 Lanthipeptides: CE047_RS18560_lanthipeptideNZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03725_lanthipeptideNZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03725_lanthipeptide

Lanthipeptides: GSN02_RS17445_lanthipeptide

5

WTTTITSLTCYGVSWVAGNNGQVCTATVECQNNC

38

W TT TS+ VS V GN G+VCT T ECQ C

4

WNTTTTSVGTILVSEVFGNKGKVCTGTKECQGTC

37

48.7%

NZ_JAGKQT010000007.1and 3 others:

NZ_JAGKQT010000007.1 Lanthipeptides: J2M30_RS09860_lanthipeptideNZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptideNZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptide

Lanthipeptides: J2M30_RS09860_lanthipeptide

8

TITSLTCYGVSWVAGNNGQVCTATVECQNNC

38

TI++ TC VS GN+G+VCT TVEC NNC

5

TISTSTCIAVSHFVGNDGKVCTYTVECVNNC

35

MIBiG 4.0 matches for MT347_RS12955

35.9%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

15

YGVSWVAGNNGQVCTATVECQNNCN

39

+ +S GNNG CT T ECQ NCN

6

FSLSNALGNNGGWCTLTKECQPNCN

30

33.3%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

15

YGVSWVAGNNGQVCTATVECQNNCN

39

Y +S GN G CT TVEC +CN

4

YNISCRLGNKGAYCTLTVECMPSCN

28

20.5%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

28

CTATVECQNNCN

39

CT + ECQ NCN

28

CTLSKECQPNCN

39

MT347_RS12965

Leader:

MTTNTHNRTGFIAEDDLVLLSENAQDVSAG

Core:

TTTAPCAVAGLTIAATAALPGFCPTGACTTRCTQG

Core with dehydrations:

DhbDhbDhbAPCysAVAGLDhbIAADhbAALPGFCysPDhbGACysDhbDhbRCysDhbQG

antiSMASH-DB 4.0 matches for MT347_RS12965

100.0%

NZ_JALGRP010000007.1and 1 other:

NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12965_lanthipeptide

Lanthipeptides: MT347_RS12965_lanthipeptide

1

TTTAPCAVAGLTIAATAALPGFCPTGACTTRCTQG

35

TTTAPCAVAGLTIAATAALPGFCPTGACTTRCTQG

1

TTTAPCAVAGLTIAATAALPGFCPTGACTTRCTQG

35

68.6%

NZ_JACSPO010000013.1and 1 other:

NZ_JACSPO010000013.1 Lanthipeptides: H9624_RS14885_lanthipeptide

Lanthipeptides: H9624_RS14885_lanthipeptide

1

TTTAPCAVAGLTIAATAALPGFCPTGACTTRC

32

TTT PCA+ G IA +AALP FCPTGACTTRC

3

TTTVPCAIGGGVIAISAALPDFCPTGACTTRC

34

45.7%

NZ_CP017762.1and 3 others:

NZ_CP017762.1 Lanthipeptides: BKP57_RS21840_lanthipeptideNZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptideNZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptide

Lanthipeptides: BKP57_RS21840_lanthipeptide

1

TTTAPCAVAGLTIAATAALPGFCPTGACTTRCTQ

34

TTT PCAVA +IA CPT AC+++C +

1

TTTVPCAVAA-SIA-------LCPTLACSSKCGE

26

with 87 more sequence matches

Only the first 10 are displayed here.

45.7%

NZ_JAENHN010000066.1and 1 other:

NZ_JAENHN010000066.1 Lanthipeptides: JHL18_RS24400_lanthipeptide

Lanthipeptides: JHL18_RS24400_lanthipeptide

5

PCAV---AGLTIAATAALPGFCPTGACTTRC

32

PCAV GLTI A+ C TGACT C

4

PCAVIATVGLTIKVATAV--VCETGACTGYC

32

42.9%

NZ_NTSF01000026.1and 1 other:

NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21840_lanthipeptide

Lanthipeptides: CN325_RS21840_lanthipeptide

1

TTTAPCAVAGLTIAATAALPGFCPTGACTTRC

32

+TT PC + G TI + A +CPT CT RC

2

STTVPCGI-GSTITISIA---YCPTSKCTERC

29

40.0%

NC_015215.1and 5 others:

NC_015215.1 Lanthipeptides: SGGBAA2069_RS00700_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09790_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09790_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05355_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05355_lanthipeptide

Lanthipeptides: SGGBAA2069_RS00700_lanthipeptide

6

CAVAGLT-IAATAALPGFCPTGACTTRCTQ

34

CA A ++ I+ +AL F T ACTTRC

5

CAWAAVSAISTVSAL--FQITTACTTRCYH

32

40.0%

NZ_CM000721.1and 9 others:

NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide

Lanthipeptides: BCERE0010_RS29355_lanthipeptide

8

VAGLTIAATAALPGFCPTGACTTRC

32

+ G TIA TA+L CPT CT+RC

14

IIGATIAVTASL---CPTTKCTSRC

35

40.0%

NZ_CP040938.1and 1 other:

NZ_CP040938.1 Lanthipeptides: B5772_RS02455_lanthipeptide

Lanthipeptides: B5772_RS02455_lanthipeptide

1

TTTAPCAVAGLTIAATAALPGFCPTGACTTRC

32

TT+ PCAV +A+TA CPT C+ +C

2

TTSIPCAV----MASTA----ICPTLVCSNKC

25

40.0%

NZ_JABBGE010000004.1and 1 other:

NZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13570_lanthipeptide

Lanthipeptides: HHL19_RS13570_lanthipeptide

2

TTAPCAVAGLTIAATAALPGFCPTGACTTRC

32

TT CAV +T AT CPT CT++C

1

TTWSCAV--VTAVATLVSASACPTTKCTSQC

29

40.0%

NZ_JAENHN010000066.1and 1 other:

NZ_JAENHN010000066.1 Lanthipeptides: JHL18_RS24410_lanthipeptide

Lanthipeptides: JHL18_RS24410_lanthipeptide

1

TTTAPCAVAGLTIAATAALPGFCPTGACTTRC

32

TTT CA+ GLT+ + CP+ ACT C

2

TTTLACAITGLTVIVVTEVA--CPSKACTGYC

31

40.0%

NZ_QKTG01000020.1and 1 other:

NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS08060_lanthipeptide

Lanthipeptides: DEI99_RS08060_lanthipeptide

16

TAALPGFCPTGACTTRC

32

+AALPGFCPTGACT++C

1

SAALPGFCPTGACTSKC

17

40.0%

NZ_QORY01000016.1and 1 other:

NZ_QORY01000016.1 Lanthipeptides: DT250_RS18265_lanthipeptide

Lanthipeptides: DT250_RS18265_lanthipeptide

2

TTAPCAVAGLTIAATAALPGFCPTGACTTRC

32

TT CA+ TIA+ A CPT AC+++C

8

TTWGCAI--FTIASAAQ----CPTTACSSKC

32

38.1%

NZ_NTSR01000029.1and 1 other:

NZ_NTSR01000029.1 Lanthipeptides: CN358_RS25165_lanthipeptide

Lanthipeptides: CN358_RS25165_lanthipeptide

2

TTAPCAV----AGLTIAATAALPGFCPTGACTTRC

32

TT PCAV G+TI CPT AC++RC

7

TTVPCAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

MIBiG 4.0 matches for MT347_RS12965

32.4%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

9

AGLTIAATAALPGFCPTGACTTRC

32

AG+ + +AA FCPT CT+RC

17

AGVAVGVSAA---FCPTTKCTSRC

37

20.0%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

22

FCPTGACTTRC

32

FCPT CT++C

16

FCPTTKCTSKC

26

20.0%

BGC0002130.3 (QKI29070.1):

Lanthipeptide: cacaoidin

2

TTAPCAV---AGLTIAATAAL

19

++APC + +I+ATA+

1

SSAPCTIYASVSASISATASW

21

allorf_190248_190481

Leader:

MGTARASRGAAPAPTGPRVRLTAAHVGGRRTGVRGA

Core:

ARPLFAATAHVSLRPTRAPPKGQTDVADRRCRRCGPQWKRS

Core with dehydrations:

ARPLFAADhbAHVDhaLRPDhbRAPPKGQDhbDVADRRCysRRCysGPQWKRDha

antiSMASH-DB 4.0 matches for allorf_190248_190481

100.0%

NZ_JALGRP010000007.1and 1 other:

NZ_JALGRP010000007.1 Lanthipeptides: allorf_190248_190481_lanthipeptide

Lanthipeptides: allorf_190248_190481_lanthipeptide

1

ARPLFAATAHVSLRPTRAPPKGQTDVADRRCRRCGPQWKRS

41

ARPLFAATAHVSLRPTRAPPKGQTDVADRRCRRCGPQWKRS

1

ARPLFAATAHVSLRPTRAPPKGQTDVADRRCRRCGPQWKRS

41

19.5%

NZ_CP039292.1and 1 other:

NZ_CP039292.1 Lanthipeptides: allorf_0076338_0076511_lanthipeptide

Lanthipeptides: allorf_0076338_0076511_lanthipeptide

21

KGQTDVADRRCRRCGPQWKRS

41

+G V+D C+ CGP +K +

6

EGSGRVSDCLCKGCGPTYKET

26

allorf_190392_190544

Leader:

MGTLRCGERRPRPRRSSVSGA

Core:

SGTFPLGAAASTPTIGHIRLALRRCTCGP

Core with dehydrations:

DhaGDhbFPLGAAADhaDhbPDhbIGHIRLALRRCysDhbCysGP

antiSMASH-DB 4.0 matches for allorf_190392_190544

100.0%

NZ_JALGRP010000007.1and 1 other:

NZ_JALGRP010000007.1 Lanthipeptides: allorf_190392_190544_lanthipeptide

Lanthipeptides: allorf_190392_190544_lanthipeptide

1

SGTFPLGAAASTPTIGHIRLALRRCTCGP

29

SGTFPLGAAASTPTIGHIRLALRRCTCGP

1

SGTFPLGAAASTPTIGHIRLALRRCTCGP

29

23.4%

NZ_BNBI01000017.1:

Lanthipeptides: allorf_050255_050446_lanthipeptide

5

PLGAAASTPTIGHIRLALRRCTCGP

29

P GAAA TP+ + L+R C P

1

PQGAAARTPS--RVHFGLQRPVCLP

23

20.7%

NZ_LMSL01000013.1:

Lanthipeptides: allorf_11540_11626_lanthipeptide

20

LALRRCTCGP

29

L++R C CGP

4

LSIRLCNCGP

13

with 1 more sequence matches

14.0%

NZ_AZVD01000036.1and 1 other:

NZ_KB898432.1 Lanthipeptides: allorf_07386_07619_lanthipeptide

Lanthipeptides: allorf_19664_19897_lanthipeptide

8

AAASTPTIGHIR

19

A S+P +GH+R

17

ALPSSPHLGHLR

28

allorf_201135_201245

Leader:

MEGERMPGV

Core:

SASAPLSCRAARRAPGGHCLRSGDAPI

Core with dehydrations:

DhaADhaAPLDhaCysRAARRAPGGHCysLRDhaGDAPI

antiSMASH-DB 4.0 matches for allorf_201135_201245

100.0%

NZ_JALGRP010000007.1and 1 other:

NZ_JALGRP010000007.1 Lanthipeptides: allorf_201135_201245_lanthipeptide

Lanthipeptides: allorf_201135_201245_lanthipeptide

1

SASAPLSCRAARRAPGGHCLRSGDAPI

27

SASAPLSCRAARRAPGGHCLRSGDAPI

1

SASAPLSCRAARRAPGGHCLRSGDAPI

27

35.7%

NZ_CP011130.1and 4 others:

NZ_CP023465.1 Lanthipeptides: CNO08_RS25790_lanthipeptideNZ_CP076103.1 Lanthipeptides: KME82_RS10615_lanthipeptideNZ_CP094357.1 Lanthipeptides: IEQ11_RS10290_lanthipeptideNZ_KQ061217.1 Lanthipeptides: WN54_RS27350_lanthipeptide

Lanthipeptides: LC55x_RS27745_lanthipeptide

1

SASAPLSCRAARRAPGGHCLRSGDAPI

27

S S+ C + + GG CL SG+ I

1

STSSFAGCNCSTSSNGG-CLCSGEVTI

26

31.2%

NZ_MUXN01000027.1:

Lanthipeptides: allorf_018463_018597_lanthipeptide

12

RRAPGGHCLRSG-DAPI

27

RRAP G R G DAP+

2

RRAPAGRSRRCGDDAPV

18

with 4 more sequence matches

25.7%

NZ_LMEQ01000012.1:

Lanthipeptides: allorf_0979470_0979679_lanthipeptide

6

LSCRAARRAPGGHCLRSGDAPI

27

L+CR R H RS D P+

5

LACRGEVRPQLVHRERSPDRPV

26

20.5%

NZ_VXKQ01000008.1:

Lanthipeptides: F3D62_RS12715_lanthipeptide

9

RAARRAPGGHCLRSGD

24

A APGGHC + D

20

NATLTAPGGHCTETTD

35

13.5%

NZ_CP007597.1:

Lanthipeptides: allorf_2301019_2301156_lanthipeptide

16

GGHCLR

21

GGHC+R

23

GGHCIR

28

10.4%

NZ_CP086102.1and 1 other:

NZ_KZ195572.1 Lanthipeptides: allorf_6130947_6131129_lanthipeptide

Lanthipeptides: allorf_6120061_6120243_lanthipeptide

19

CLRSGDAP

26

C+R+G+AP

10

CIRTGEAP

17

MIBiG 4.0 matches for allorf_201135_201245

9.8%

BGC0002120.3 (NQE92413.1):

Lanthipeptide: nocathioamide A

14

APGGHCLRS

22

AP H L S

37

APACHTLSS

45

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.26 out of 19.26

Confidence: medium

Additional weak hits (6):

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 18.61 out of 30.97

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.90 out of 28.19

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.01 out of 27.04

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 18.93 out of 36.54

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.30 out of 21.84

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 20.85 out of 35.63

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

MT347_RS12955 - Class II

Cleavage pHMM score: -7.00

RODEO score: 0

Monoisotopic mass: 3888.8 Da

Molecular weight: 3891.2 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3909.2 Da N = 1; 3927.3 Da N = 2; 3945.3 Da N = 3; 3963.3 Da N = 4; 3981.3 Da N = 5

MT347_RS12965 - Class II

Cleavage pHMM score: -4.80

RODEO score: 0

Monoisotopic mass: 3134.6 Da

Molecular weight: 3136.6 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3154.6 Da N = 1; 3172.6 Da N = 2; 3190.7 Da N = 3; 3208.7 Da N = 4; 3226.7 Da N = 5

allorf_190248_190481 - Class II

Cleavage pHMM score: -4.30

RODEO score: 0

Monoisotopic mass: 4522.4 Da

Molecular weight: 4525.2 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 4543.2 Da N = 1; 4561.2 Da N = 2; 4579.2 Da N = 3

allorf_190392_190544 - Class II

Cleavage pHMM score: -2.00

RODEO score: 0

Monoisotopic mass: 2815.5 Da

Molecular weight: 2817.3 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2835.3 Da N = 1; 2853.3 Da N = 2; 2871.3 Da N = 3; 2889.4 Da N = 4

allorf_201135_201245 - Class II

Cleavage pHMM score: -5.00

RODEO score: 0

Monoisotopic mass: 2604.3 Da

Molecular weight: 2605.9 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2624.0 Da N = 1; 2642.0 Da N = 2

MT347_RS12955 - Class II

Cleavage pHMM score: -7.00

RODEO score: 0

Monoisotopic mass: 3888.8 Da

Molecular weight: 3891.2 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3909.2 Da N = 1; 3927.3 Da N = 2; 3945.3 Da N = 3; 3963.3 Da N = 4; 3981.3 Da N = 5

MT347_RS12965 - Class II

Cleavage pHMM score: -4.80

RODEO score: 0

Monoisotopic mass: 3134.6 Da

Molecular weight: 3136.6 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3154.6 Da N = 1; 3172.6 Da N = 2; 3190.7 Da N = 3; 3208.7 Da N = 4; 3226.7 Da N = 5

allorf_190248_190481 - Class II

Cleavage pHMM score: -4.30

RODEO score: 0

Monoisotopic mass: 4522.4 Da

Molecular weight: 4525.2 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 4543.2 Da N = 1; 4561.2 Da N = 2; 4579.2 Da N = 3

allorf_190392_190544 - Class II

Cleavage pHMM score: -2.00

RODEO score: 0

Monoisotopic mass: 2815.5 Da

Molecular weight: 2817.3 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2835.3 Da N = 1; 2853.3 Da N = 2; 2871.3 Da N = 3; 2889.4 Da N = 4

allorf_201135_201245 - Class II

Cleavage pHMM score: -5.00

RODEO score: 0

Monoisotopic mass: 2604.3 Da

Molecular weight: 2605.9 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2624.0 Da N = 1; 2642.0 Da N = 2

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein

NZ_JALGRP010000008.1 - Region 1 - NAPAA

Download region GenBank file

Download region SVG

Location: 104,735 - 138,679 nt. (total: 33,945 nt) Show pHMM detection rules used

NAPAA: (AMP-binding and TIGR02353)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

MT347_RS13505: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Hydrolases: dehalogenase

MT347_RS13500: haloalkane dehalogenase

smcogs: SMCOG1262: haloalkane dehalogenase

Isomerases: mutase

MT347_RS13640: phosphoglycerate mutase

smcogs: SMCOG1101: phosphoglycerate mutase

Ligases: ligase

MT347_RS13580: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002174.2	0.77	NRPS	ε-Poly-L-lysine	Epichloe festucae
BGC0001135.5	0.61	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001249.5	0.60	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001250.4	0.60	NRPS	epichloenin A	Epichloe festucae
BGC0001251.4	0.60	NRPS	epichloenin A	Epichloe festucae
BGC0001833.4	0.59	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001240.4	0.59	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0002286.3	0.59	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001166.5	0.59	NRPS	HC-toxin	Alternaria jesenskae
BGC0001641.4	0.59	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002174.2	0.77	NRPS	ε-Poly-L-lysine	Epichloe festucae
BGC0001135.5	0.61	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001249.5	0.60	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001250.4	0.60	NRPS	epichloenin A	Epichloe festucae
BGC0001251.4	0.60	NRPS	epichloenin A	Epichloe festucae
BGC0001833.4	0.59	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001240.4	0.59	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0002286.3	0.59	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001166.5	0.59	NRPS	HC-toxin	Alternaria jesenskae
BGC0001641.4	0.59	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (9):

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.67 out of 27.78

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 20.45 out of 30.97

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 24.23 out of 36.53

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 24.31 out of 36.53

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 16.77 out of 26.06

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.73 out of 18.57

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.83 out of 28.14

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.37 out of 28.19

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 18.31 out of 33.14

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 104734 - 138679:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

MT347_RS13580: X

AMP-binding (29..418): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: FAELFDASCEELSTIFGGEWNTYGPTEATVVACA
Nearest Stachelhaus code(s):: Lys DAEDIGTVVK (71% 8Å match); Gln or Tyr DAESVGTVVK (65% 8Å match)
Stachelhaus code match:: 90% (moderate)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description