Select genomic region:
Overview
12.1
12.2
15.1
24.1
24.2
25.1
27.1
27.2
28.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_JALGRP010000002.1 (Microbacterium sp. VKM Ac-2923)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 12.1 | terpene | 181,128 | 205,301 | Low | carotenoid | terpene
Region 12.2 | linaridin | 494,407 | 516,990 | Low | cypemycin | ribosomal:RiPP:Linaridin

NZ_JALGRP010000022.1 (Microbacterium sp. VKM Ac-2923)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 15.1 | RiPP-like | 1 | 10,891 |

NZ_JALGRP010000004.1 (Microbacterium sp. VKM Ac-2923)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 24.1 | T3PKS | 1 | 30,095 |
Region 24.2 | terpene-precursor | 178,777 | 199,838 | Low | clifednamide A | NRPS:Type I+PKS

NZ_JALGRP010000005.1 (Microbacterium sp. VKM Ac-2923)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 25.1 | terpene-precursor,betalactone | 82,781 | 119,428 |  |

NZ_JALGRP010000007.1 (Microbacterium sp. VKM Ac-2923)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 27.1 | NRP-metallophore,NRPS | 70,307 | 152,110 | Low | cahuitamycin A/cahuitamycin B/cahuitamycin C | NRPS:Type I
Region 27.2 | lanthipeptide-class-ii | 180,790 | 206,815 |

NZ_JALGRP010000008.1 (Microbacterium sp. VKM Ac-2923)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 28.1 | NAPAA | 104,735 | 138,679 | High | ε-Poly-L-lysine | NRPS:Type I

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 12.1 | terpene | 181,128 | 205,301 | Low | carotenoid | terpene
Region 12.2 | linaridin | 494,407 | 516,990 | Low | cypemycin | ribosomal:RiPP:Linaridin
Region 15.1 | RiPP-like | 1 | 10,891 |
Region 24.1 | T3PKS | 1 | 30,095 |
Region 24.2 | terpene-precursor | 178,777 | 199,838 | Low | clifednamide A | NRPS:Type I+PKS
Region 25.1 | terpene-precursor,betalactone | 82,781 | 119,428 |  |
Region 27.1 | NRP-metallophore,NRPS | 70,307 | 152,110 | Low | cahuitamycin A/cahuitamycin B/cahuitamycin C | NRPS:Type I
Region 27.2 | lanthipeptide-class-ii | 180,790 | 206,815 |
Region 28.1 | NAPAA | 104,735 | 138,679 | High | ε-Poly-L-lysine | NRPS:Type I

No secondary metabolite regions were found in these records:
  NZ_JALGRP010000001.1 (Microbacterium sp. VKM Ac-2923)
  NZ_JALGRP010000010.1 (Microbacterium sp. VKM Ac-2923)
  NZ_JALGRP010000011.1 (Microbacterium sp. VKM Ac-2923)
  NZ_JALGRP010000012.1 (Microbacterium sp. VKM Ac-2923)
  NZ_JALGRP010000013.1 (Microbacterium sp. VKM Ac-2923)
  NZ_JALGRP010000014.1 (Microbacterium sp. VKM Ac-2923)
  NZ_JALGRP010000015.1 (Microbacterium sp. VKM Ac-2923)
  NZ_JALGRP010000016.1 (Microbacterium sp. VKM Ac-2923)
  NZ_JALGRP010000017.1 (Microbacterium sp. VKM Ac-2923)
  NZ_JALGRP010000018.1 (Microbacterium sp. VKM Ac-2923)
  NZ_JALGRP010000019.1 (Microbacterium sp. VKM Ac-2923)
  NZ_JALGRP010000020.1 (Microbacterium sp. VKM Ac-2923)
  NZ_JALGRP010000021.1 (Microbacterium sp. VKM Ac-2923)
  NZ_JALGRP010000023.1 (Microbacterium sp. VKM Ac-2923)
  NZ_JALGRP010000024.1 (Microbacterium sp. VKM Ac-2923)
  NZ_JALGRP010000025.1 (Microbacterium sp. VKM Ac-2923)
  NZ_JALGRP010000026.1 (Microbacterium sp. VKM Ac-2923)
  NZ_JALGRP010000027.1 (Microbacterium sp. VKM Ac-2923)
  NZ_JALGRP010000028.1 (Microbacterium sp. VKM Ac-2923)
  NZ_JALGRP010000029.1 (Microbacterium sp. VKM Ac-2923)
  NZ_JALGRP010000003.1 (Microbacterium sp. VKM Ac-2923)
  NZ_JALGRP010000006.1 (Microbacterium sp. VKM Ac-2923)
  NZ_JALGRP010000009.1 (Microbacterium sp. VKM Ac-2923)

Compact view
NZ_JALGRP010000002.1 - Region 1 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 181,128 - 205,301 nt. (total: 24,174 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
MT347_RS04095: dehydrogenase

smcogs
  SMCOG1222: dehydrogenase

Ligases: synthetase
MT347_RS04085: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000637.3 |  | 0.67 | terpene | carotenoid | Corynebacterium glutamicum
BGC0000644.3 |  | 0.61 | terpene | carotenoid | Dietzia sp. CQ4
BGC0000650.3 |  | 0.59 | terpene | carotenoid | Algoriphagus sp. KK10202C
BGC0000647.3 |  | 0.57 | terpene | carotenoid | Rhodobacter sphaeroides
BGC0000648.3 |  | 0.50 | terpene | carotenoid | Myxococcus xanthus
BGC0000636.3 |  | 0.49 | terpene | carotenoid | Brevibacterium linens
BGC0001456.3 |  | 0.48 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000643.3 |  | 0.44 | terpene | carotenoid | Brevundimonas vesicularis
BGC0000634.3 |  | 0.44 | terpene | carotenoid | Brevundimonas sp. SD212
BGC0000391.5 |  | 0.37 | NRPS | methylpendolmycin, pendolmycin | Marinactinospora thermotolerans

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000637.3 |  | 0.67 | terpene | carotenoid | Corynebacterium glutamicum
BGC0000644.3 |  | 0.61 | terpene | carotenoid | Dietzia sp. CQ4
BGC0000650.3 |  | 0.59 | terpene | carotenoid | Algoriphagus sp. KK10202C
BGC0000647.3 |  | 0.57 | terpene | carotenoid | Rhodobacter sphaeroides
BGC0000648.3 |  | 0.50 | terpene | carotenoid | Myxococcus xanthus
BGC0000636.3 |  | 0.49 | terpene | carotenoid | Brevibacterium linens
BGC0001456.3 |  | 0.48 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000643.3 |  | 0.44 | terpene | carotenoid | Brevundimonas vesicularis
BGC0000634.3 |  | 0.44 | terpene | carotenoid | Brevundimonas sp. SD212
BGC0000391.5 |  | 0.37 | NRPS | methylpendolmycin, pendolmycin | Marinactinospora thermotolerans

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
tetraterpene | C40 carotenoid |  | C40 | unknown | unknown

Genes with terpene domains:
MT347_RS04085: PT_FPPS_like
Domain 1 (47 - 351): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: unknown

Reactions:
  IPP, DMAPP → FPP
  IPP, DMAPP → GGPP
  IPP, DMAPP → GFPP
  IPP, DMAPP → HPP

MT347_RS04090: PT_phytoene_like
Domain 1 (23 - 203): Prenyltransferase; Phytoene synthase like
Subtype: unknown

Reactions:
  FPP → PSPP
  FPP → squalene
  FPP → diapophytoene
  GGPP → phytoene
  PSPP → hydroxysqualene

MT347_RS04100: Lycopene_cycl
Domain 1 (4 - 93): Lycopene cyclase

Reactions:
  C40_carotenoid → C40_carotenoid

MT347_RS04105: Lycopene_cycl
Domain 1 (2 - 91): Lycopene cyclase

Reactions:
  C40_carotenoid → C40_carotenoid

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
No hits above weak threshold.
Weak hits (4):
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.55 out of 27.78
Confidence: weak
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.69 out of 20.97
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 17.93 out of 29.25
Confidence: weak
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.47 out of 26.33
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
GFPP | Geranylfarnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
HPP | Hexaprenyl diphosphate
IPP | Isopentenyl diphosphate
PSPP | Presqualene diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---

NZ_JALGRP010000002.1 - Region 2 - linaridin
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 494,407 - 516,990 nt. (total: 22,584 nt) Show pHMM detection rules used
linaridin: (cypemycin or cypI)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | linaridin | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002319.3 |  | 0.66 | ribosomal | salinipeptin A, salinipeptin B, salinipeptin C, salinipeptin D | Streptomyces sp.
BGC0000583.5 |  | 0.64 | ribosomal | grisemycin | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000582.4 |  | 0.62 | ribosomal | cypemycin | Streptomyces sp. OH-4156
BGC0001188.3 |  | 0.41 | ribosomal | legonaridin | Streptomyces sp. CT34
BGC0000543.5 |  | 0.39 | ribosomal | pep5 | Staphylococcus epidermidis
BGC0001735.5 |  | 0.35 | other (other) | pentostatine, vidarabine | Streptomyces antibioticus
BGC0002362.3 |  | 0.28 | PKS | loseolamycin A1, loseolamycin A2 | Micromonospora endolithica
BGC0000374.5 |  | 0.25 | NRPS | hormaomycin, hormaomycin A1, hormaomycin A2, hormaomycin A3, hormaomycin A4, hormaomycin A5, hormaomycin A6 | Streptomyces griseoflavus
BGC0001020.5 |  | 0.21 | NRPS, PKS | muraymycin C1 | Streptomyces sp. NRRL 30471

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002319.3 |  | 0.66 | ribosomal | salinipeptin A, salinipeptin B, salinipeptin C, salinipeptin D | Streptomyces sp.
BGC0000583.5 |  | 0.64 | ribosomal | grisemycin | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000582.4 |  | 0.62 | ribosomal | cypemycin | Streptomyces sp. OH-4156
BGC0001188.3 |  | 0.41 | ribosomal | legonaridin | Streptomyces sp. CT34
BGC0000543.5 |  | 0.39 | ribosomal | pep5 | Staphylococcus epidermidis
BGC0001735.5 |  | 0.35 | other (other) | pentostatine, vidarabine | Streptomyces antibioticus
BGC0002362.3 |  | 0.28 | PKS | loseolamycin A1, loseolamycin A2 | Micromonospora endolithica
BGC0000374.5 |  | 0.25 | NRPS | hormaomycin, hormaomycin A1, hormaomycin A2, hormaomycin A3, hormaomycin A4, hormaomycin A5, hormaomycin A6 | Streptomyces griseoflavus
BGC0001020.5 |  | 0.21 | NRPS, PKS | muraymycin C1 | Streptomyces sp. NRRL 30471

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.43 out of 20.97
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.78 out of 24.78
Confidence: medium
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.50 out of 20.47
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.89 out of 18.16
Confidence: strong
Additional weak hits (5):
BldD
Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.94 out of 23.43
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 23.05 out of 29.65
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.91 out of 20.01
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 19.07 out of 29.25
Confidence: weak
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.33 out of 27.04
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CcpA | Catabolite control protein A
LexA variant 2 | Repressor of DNA damage response
VqsM | Regulator of quorum-sensing signalling systems

NZ_JALGRP010000022.1 - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 10,891 nt. (total: 10,891 nt) Show pHMM detection rules used
Region on contig edge.
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002115.3 |  | 0.53 | ribosomal | streptamidine | Streptomyces albidoflavus J1074
BGC0001638.4 |  | 0.51 | ribosomal | klebsazolicin | Klebsiella pneumoniae subsp. ozaenae
BGC0000501.3 |  | 0.48 | ribosomal | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0000551.5 |  | 0.43 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000513.3 |  | 0.42 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000519.4 |  | 0.42 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0001639.3 |  | 0.41 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0002698.2 |  | 0.40 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0000569.5 |  | 0.37 | ribosomal | plantazolicin | Bacillus velezensis FZB42

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002115.3 |  | 0.53 | ribosomal | streptamidine | Streptomyces albidoflavus J1074
BGC0001638.4 |  | 0.51 | ribosomal | klebsazolicin | Klebsiella pneumoniae subsp. ozaenae
BGC0000501.3 |  | 0.48 | ribosomal | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0000551.5 |  | 0.43 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000513.3 |  | 0.42 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000519.4 |  | 0.42 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0001639.3 |  | 0.41 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0002698.2 |  | 0.40 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0000569.5 |  | 0.37 | ribosomal | plantazolicin | Bacillus velezensis FZB42

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.68 out of 29.38
Confidence: medium
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.92 out of 20.47
Confidence: medium
Additional weak hits (8):
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 16.13 out of 29.25
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.77 out of 29.38
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.11 out of 32.74
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 15.78 out of 28.14
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 16.44 out of 28.14
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.79 out of 29.38
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.10 out of 28.14
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.52 out of 28.19
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
FuR variant 1 | Ferric Uptake Regulator
VqsM | Regulator of quorum-sensing signalling systems

NZ_JALGRP010000004.1 - Region 1 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 30,095 nt. (total: 30,095 nt) Show pHMM detection rules used
Region on contig edge.
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase oxygenase
MT347_RS07855: monooxygenase FAD-binding

smcogs
  SMCOG1050: monooxygenase FAD-binding

MT347_RS07910: aldo/keto reductase family oxidoreductase

smcogs
  SMCOG1039: aldo/keto reductase family oxidoreductase

Transferases: acetyltransferase glycosyltransferase
MT347_RS07795: GCN5-related N-acetyltransferase

smcogs
  SMCOG1111: GCN5-related N-acetyltransferase

MT347_RS07830: glycosyl transferase group 1

smcogs
  SMCOG1045: glycosyl transferase group 1

Hydrolases: glucosidase
MT347_RS07860: Alpha-glucosidase

smcogs
  SMCOG1257: Alpha-glucosidase

MT347_RS07885: Alpha-glucosidase

smcogs
  SMCOG1257: Alpha-glucosidase

Ligases: synthase
MT347_RS07845: chalcone and stilbene synthase domain protein

smcogs
  SMCOG1024: chalcone and stilbene synthase domain protein

Translocases: transporter
MT347_RS07880: sugar-binding lipoprotein

smcogs
  SMCOG1143: sugar-binding lipoprotein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000282.3 |  | 0.54 | PKS | 2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001962.3 |  | 0.51 | PKS | hierridin B, hierridin C | Cyanobium sp. LEGE 06113
BGC0002403.2 |  | 0.49 | PKS | β-Diketones | Hordeum vulgare subsp. vulgare
BGC0001077.4 |  | 0.47 | PKS | 6-anteisoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-geranyl-2-methoxyhydroquinone, 6-palmityl-4-O-geranyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-palmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone | Actinoplanes missouriensis 431
BGC0002285.2 |  | 0.46 | ribosomal | aborycin | Streptomyces sp. ZS0098
BGC0002332.2 |  | 0.45 | PKS | 4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A | Candidatus Entotheonella sp.
BGC0001831.3 |  | 0.45 | PKS | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0002362.3 |  | 0.45 | PKS | loseolamycin A1, loseolamycin A2 | Micromonospora endolithica
BGC0002690.2 |  | 0.43 | other (other) | FW0622 | Verrucosispora sp. FIM060022
BGC0001810.3 |  | 0.42 | PKS | trehangelin | Polymorphospora rubra

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000282.3 |  | 0.54 | PKS | 2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001962.3 |  | 0.51 | PKS | hierridin B, hierridin C | Cyanobium sp. LEGE 06113
BGC0002403.2 |  | 0.49 | PKS | β-Diketones | Hordeum vulgare subsp. vulgare
BGC0001077.4 |  | 0.47 | PKS | 6-anteisoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-geranyl-2-methoxyhydroquinone, 6-palmityl-4-O-geranyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-palmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone | Actinoplanes missouriensis 431
BGC0002285.2 |  | 0.46 | ribosomal | aborycin | Streptomyces sp. ZS0098
BGC0002332.2 |  | 0.45 | PKS | 4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A | Candidatus Entotheonella sp.
BGC0001831.3 |  | 0.45 | PKS | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0002362.3 |  | 0.45 | PKS | loseolamycin A1, loseolamycin A2 | Micromonospora endolithica
BGC0002690.2 |  | 0.43 | other (other) | FW0622 | Verrucosispora sp. FIM060022
BGC0001810.3 |  | 0.42 | PKS | trehangelin | Polymorphospora rubra

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 26.64 out of 30.11
Confidence: medium
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 25.16 out of 30.11
Confidence: medium
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 18.42 out of 19.52
Confidence: strong
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.46 out of 23.05
Confidence: medium
Additional weak hits (7):
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.06 out of 27.78
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 17.55 out of 29.25
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 20.42 out of 33.73
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.48 out of 21.55
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 19.34 out of 35.63
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 21.90 out of 30.11
Confidence: weak
NrdR
Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 20.71 out of 27.18
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsQ1 | Two-component system AfsQ1-Q2, activator of antibiotic production
AfsR | Pleiotropic regulatory for antibiotic production
CelR | Cellobiose uptake repressor

NZ_JALGRP010000004.1 - Region 2 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 178,777 - 199,838 nt. (total: 21,062 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidase
MT347_RS08760: pyruvate oxidase/decarboxylase

smcogs
  SMCOG1055: pyruvate oxidase/decarboxylase

Transferases: methyltransferase
MT347_RS08740: methyltransferase

smcogs
  SMCOG1089: methyltransferase

Lyases: hydratase
MT347_RS08785: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

Isomerases: isomerase
MT347_RS08750: isochorismate synthase

smcogs
  SMCOG1018: isochorismate synthase

Ligases: ligase synthetase
MT347_RS08735: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

MT347_RS08780: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Translocases: transporter
MT347_RS08720: sugar-binding lipoprotein

smcogs
  SMCOG1143: sugar-binding lipoprotein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001641.4 |  | 0.56 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000913.3 |  | 0.46 | other (other) | MK-8 | Enterobacter cloacae
BGC0001553.5 |  | 0.45 | NRPS, PKS | clifednamide A | Streptomyces sp. JV178
BGC0001529.5 |  | 0.44 | other (other) | benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K | Streptomyces sp. RI18
BGC0001137.5 |  | 0.41 | other (other) | marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D | Marinactinospora thermotolerans
BGC0000451.5 |  | 0.40 | NRPS | turnerbactin | Teredinibacter turnerae T7901
BGC0002538.3 |  | 0.39 | PKS | chaetolivacine A, chaetolivacine B, chaetolivacine C | Chaetomium olivaceum
BGC0000905.5 |  | 0.39 | other (other) | heme D1 | Heliobacillus mobilis
BGC0000906.3 |  | 0.39 | other (other) | heme D1 | Heliophilum fasciatum
BGC0001594.3 |  | 0.38 | other (other) | fischerindole L | Fischerella muscicola UTEX 1829

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001641.4 |  | 0.56 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000913.3 |  | 0.46 | other (other) | MK-8 | Enterobacter cloacae
BGC0001553.5 |  | 0.45 | NRPS, PKS | clifednamide A | Streptomyces sp. JV178
BGC0001529.5 |  | 0.44 | other (other) | benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K | Streptomyces sp. RI18
BGC0001137.5 |  | 0.41 | other (other) | marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D | Marinactinospora thermotolerans
BGC0000451.5 |  | 0.40 | NRPS | turnerbactin | Teredinibacter turnerae T7901
BGC0002538.3 |  | 0.39 | PKS | chaetolivacine A, chaetolivacine B, chaetolivacine C | Chaetomium olivaceum
BGC0000905.5 |  | 0.39 | other (other) | heme D1 | Heliobacillus mobilis
BGC0000906.3 |  | 0.39 | other (other) | heme D1 | Heliophilum fasciatum
BGC0001594.3 |  | 0.38 | other (other) | fischerindole L | Fischerella muscicola UTEX 1829

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP
diterpene precursor |  | GGPP | C20 | acyclic | PP
sesterterpene precursor |  | GFPP | C25 | acyclic | PP
triterpene precursor |  | HPP | C30 | acyclic | PP

Genes with terpene domains:
MT347_RS08735: PT_FPPS_like
Domain 1 (61 - 351): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: unknown

Reactions:
  IPP, DMAPP → FPP
  IPP, DMAPP → GGPP
  IPP, DMAPP → GFPP
  IPP, DMAPP → HPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.13 out of 19.26
Confidence: medium
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 18.49 out of 25.31
Confidence: medium
Additional weak hits (2):
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.68 out of 30.22
Confidence: weak
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.86 out of 19.52
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
GFPP | Geranylfarnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
HPP | Hexaprenyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
CatR | H2O2-responsive repressor

NZ_JALGRP010000005.1 - Region 1 - betalactone,terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 82,781 - 119,428 nt. (total: 36,648 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
MT347_RS10150: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Transferases: acyltransferase
MT347_RS10095: acyltransferase

smcogs
  SMCOG1141: acyltransferase

Hydrolases: deformylase
MT347_RS10110: peptide deformylase

smcogs
  SMCOG1275: peptide deformylase

Ligases: ligase synthase synthetase
MT347_RS10070: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

MT347_RS10105: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

MT347_RS10120: 2-isopropylmalate synthase

smcogs
  SMCOG1271: 2-isopropylmalate synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000677.5 |  |  | 0.30 | terpene | cyclooctatin | Streptomyces melanosporofaciens
BGC0002309.2 |  |  | 0.30 | terpene | cattleyene | Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0001910.4 |  |  | 0.27 | terpene | cyslabdan A, cyslabdan B, cyslabdan C | Streptomyces cyslabdanicus
BGC0001911.3 |  |  | 0.26 | terpene | raimonol | Streptomyces anulatus
BGC0000664.5 |  |  | 0.26 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001456.3 |  |  | 0.26 | terpene | isorenieratene | Streptomyces argillaceus
BGC0002561.3 |  |  | 0.25 | other (other) | phenazine SA, phenazine SB, phenazine SC | Streptomyces sp.
BGC0000633.3 |  |  | 0.25 | terpene | carotenoid | Streptomyces avermitilis
BGC0000649.3 |  |  | 0.25 | terpene | carotenoid | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000936.5 |  |  | 0.25 | other (other) | pyocyanine | Pseudomonas aeruginosa PAO1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002309.2 |  | 0.47 | terpene | cattleyene | Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000677.5 |  | 0.45 | terpene | cyclooctatin | Streptomyces melanosporofaciens
BGC0000649.3 |  | 0.43 | terpene | carotenoid | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001911.3 |  | 0.43 | terpene | raimonol | Streptomyces anulatus
BGC0001910.4 |  | 0.43 | terpene | cyslabdan A, cyslabdan B, cyslabdan C | Streptomyces cyslabdanicus
BGC0000664.5 |  | 0.43 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0002561.3 |  | 0.42 | other (other) | phenazine SA, phenazine SB, phenazine SC | Streptomyces sp.
BGC0001456.3 |  | 0.42 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000633.3 |  | 0.42 | terpene | carotenoid | Streptomyces avermitilis
BGC0001227.3 |  | 0.42 | terpene | isorenieratene | Streptomyces collinus Tu 365

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP
diterpene precursor |  | GGPP | C20 | acyclic | PP
sesterterpene precursor |  | GFPP | C25 | acyclic | PP
triterpene precursor |  | HPP | C30 | acyclic | PP

Genes with terpene domains:
MT347_RS10070: PT_FPPS_like
Domain 1 (43 - 354): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: unknown

Reactions:
  IPP, DMAPP → FPP
  IPP, DMAPP → GGPP
  IPP, DMAPP → GFPP
  IPP, DMAPP → HPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
No hits above weak threshold.
Weak hits (6):
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.44 out of 30.22
Confidence: weak
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.38 out of 21.84
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.50 out of 30.22
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 19.59 out of 33.73
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.61 out of 30.22
Confidence: weak
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.28 out of 26.85
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
GFPP | Geranylfarnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
HPP | Hexaprenyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---

NZ_JALGRP010000007.1 - Region 1 - NRP-metallophore,NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 70,307 - 152,110 nt. (total: 81,804 nt) Show pHMM detection rules used
NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase oxygenase
MT347_RS12680: lysine/ornithine N-monooxygenase

smcogs
  SMCOG1080: lysine/ornithine N-monooxygenase

MT347_RS12755: aldo/keto reductase family oxidoreductase

smcogs
  SMCOG1039: aldo/keto reductase family oxidoreductase

MT347_RS12765: aldo/keto reductase family oxidoreductase

smcogs
  SMCOG1039: aldo/keto reductase family oxidoreductase

Transferases: PPTase formyltransferase methyltransferase
MT347_RS12625: methyltransferase

smcogs
  SMCOG1089: methyltransferase

MT347_RS12700: methionyl-tRNA formyltransferase

smcogs
  SMCOG1228: methionyl-tRNA formyltransferase

MT347_RS12720: methionyl-tRNA formyltransferase

smcogs
  SMCOG1228: methionyl-tRNA formyltransferase

MT347_RS18420: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1060: 4'-phosphopantetheinyl transferase

Hydrolases: hydrolase
MT347_RS12740: alpha/beta hydrolase fold protein

smcogs
  SMCOG1036: alpha/beta hydrolase fold protein

Ligases: ligase
MT347_RS12695: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

MT347_RS12725: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

MT347_RS12730: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRP-metallophore | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001135.5 |  |  | 0.86 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0002135.2 |  |  | 0.85 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001261.3 |  |  | 0.83 | NRPS | AM-toxin | Alternaria alternata
BGC0001128.4 |  |  | 0.82 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4 |  |  | 0.82 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002286.3 |  |  | 0.82 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  |  | 0.81 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001132.4 |  |  | 0.80 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.4 |  |  | 0.79 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001240.4 |  |  | 0.78 | NRPS | serinocyclin A, serinocyclin B | Metarhizium robertsii

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001135.5 |  | 0.74 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0002135.2 |  | 0.74 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001261.3 |  | 0.73 | NRPS | AM-toxin | Alternaria alternata
BGC0001128.4 |  | 0.73 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4 |  | 0.73 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002286.3 |  | 0.72 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  | 0.72 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001132.4 |  | 0.72 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.4 |  | 0.72 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001240.4 |  | 0.71 | NRPS | serinocyclin A, serinocyclin B | Metarhizium robertsii

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.65 out of 18.46
Confidence: strong
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 28.19 out of 36.53
Confidence: medium
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 31.19 out of 36.53
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.46 out of 23.79
Confidence: medium
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.82 out of 21.84
Confidence: medium
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.92 out of 20.47
Confidence: medium
Additional weak hits (31):
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 18.12 out of 26.12
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.02 out of 26.06
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.28 out of 27.78
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.33 out of 29.38
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.63 out of 39.62
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 21.50 out of 32.74
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 21.17 out of 32.74
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.10 out of 29.38
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.07 out of 39.62
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.58 out of 29.38
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.95 out of 27.78
Confidence: weak
NrdR
Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 20.86 out of 27.18
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 17.80 out of 33.14
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 25.27 out of 36.53
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 36.53
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.24 out of 36.53
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 15.85 out of 28.14
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 17.69 out of 28.14
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.86 out of 28.14
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 21.41 out of 36.53
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.49 out of 39.62
Confidence: weak
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.64 out of 21.84
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 21.05 out of 32.74
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 19.12 out of 35.63
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.49 out of 29.65
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.49 out of 29.65
Confidence: weak
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 19.14 out of 22.40
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.19 out of 29.65
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.95 out of 29.65
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 21.59 out of 35.63
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.23 out of 30.98
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 70306 - 152110:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Fo-OH-Orn - X) + (Ser - D-Ser - X - X - X - D-Orn)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
MT347_RS12695: diOH-Bz
Search NORINE for peptide: strict or relaxed
AMP-binding (37..443): diOH-Bz
nrpys: diOH-Bz

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Small clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Single AA prediction:
    dhb (diOH-Bz)

Stachelhaus prediction details:
  Stachelhaus sequence:
    SVSVHSMSVPGGSIHVGGAQQGFGMAEGLVNYVR
  Nearest Stachelhaus code(s):
    diOH-Bz PMPSGGVVNK (74% 8Å match)
  Stachelhaus code match:
    70% (weak)

MT347_RS12725: Fo-OH-Orn - X
Search NORINE for peptide: strict or relaxed
AMP-binding (25..428): Fo-OH-Orn
nrpys: Fo-OH-Orn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Long positively charged side chain (Orn, Lys, Arg)
  Small clusters prediction:
    Orn and hydroxy-Orn specific (Orn, OH-Orn)
  Single AA prediction:
    orn (Orn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    RWQAFDISINELYLWCGGEYHGYGPAEATIGVSH
  Nearest Stachelhaus code(s):
    Fo-OH-Orn DINYWGGIGK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1095..1519): X
nrpys: (unknown)

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    RWGSFVDAATEGLTVTSGEHNFYGSTEITGDATV
  Nearest Stachelhaus code(s):
    bAla VDTVVSFGDK (68% 8Å match)
  Stachelhaus code match:
    90% (moderate)

MT347_RS12730: Ser - Ser - X - X - X - Orn
Search NORINE for peptide: strict or relaxed
AMP-binding (467..880): Ser
nrpys: Ser

SVM prediction details:
  Predicted physicochemical class:
    N/A
  Large clusters prediction:
    N/A
  Small clusters prediction:
    ser (Ser)
  Single AA prediction:
    ser (Ser)

Stachelhaus prediction details:
  Stachelhaus sequence:
    RWATFDASLWEVHFFVSGEDNVYGPTETTVDVTS
  Nearest Stachelhaus code(s):
    Ser DVWHFSLVDK (74% 8Å match)
  Stachelhaus code match:
    80% (moderate)

AMP-binding (1555..1961): Ser
nrpys: Ser

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    ser (Ser)
  Single AA prediction:
    ser (Ser)

Stachelhaus prediction details:
  Stachelhaus sequence:
    RWMTFDVSVWELHFFFSGEHNLYGPTEAAVDVTA
  Nearest Stachelhaus code(s):
    Ser DVWHFSLVDK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (3107..3511): X
nrpys: Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LWRTFDVSVPEWELSVGGEWNTYGPTEAAVETTG
  Nearest Stachelhaus code(s):
    meSer DVFESGGVAK (65% 8Å match)
    Lys DVFESGGVAK (62% 8Å match)
  Stachelhaus code match:
    70% (weak)

AMP-binding (4173..4583): X
nrpys: Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LWRTFDVAVPEWELSVGGEWNTYGPTEAAVETTG
  Nearest Stachelhaus code(s):
    meSer DVFESGGVAK (62% 8Å match)
    Lys DVFESGGVAK (59% 8Å match)
  Stachelhaus code match:
    70% (weak)

AMP-binding (5247..5656): X
nrpys: Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LWRTFDVSVPEWELSVGGEWNTYGPTEAAVETTG
  Nearest Stachelhaus code(s):
    meSer DVFESGGVAK (65% 8Å match)
    Lys DVFESGGVAK (62% 8Å match)
  Stachelhaus code match:
    70% (weak)

AMP-binding (7134..7552): Orn
nrpys: Orn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Long positively charged side chain (Orn, Lys, Arg)
  Small clusters prediction:
    Orn and hydroxy-Orn specific (Orn, OH-Orn)
  Single AA prediction:
    orn (Orn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    MNHTFDASWEQWDVSLGGEYNLYGPTEYTINALG
  Nearest Stachelhaus code(s):
    OH-Orn DMENLGLINK (82% 8Å match)
  Stachelhaus code match:
    70% (weak)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
DmdR1 | Iron(II)-dependent repressor
IolR | Regulator of the inositol catabolism
MexT | Global virulence regulator
RpoN | Regulator of nitrogen assimilation and virulence
VqsM | Regulator of quorum-sensing signalling systems

NZ_JALGRP010000007.1 - Region 2 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 180,790 - 206,815 nt. (total: 26,026 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidase oxidoreductase
MT347_RS12930: NADH:flavin oxidoreductase/NADH oxidase

smcogs
  SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

MT347_RS12935: FAD linked oxidase domain protein

smcogs
  SMCOG1138: FAD linked oxidase domain protein

MT347_RS18425: FAD linked oxidase domain protein

smcogs
  SMCOG1138: FAD linked oxidase domain protein

Lyases: cyclase
MT347_RS12960: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

MT347_RS12970: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001229.4 |  | 0.61 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000517.4 |  | 0.60 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0002110.3 |  | 0.55 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0000528.5 |  | 0.55 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001311.5 |  | 0.52 | ribosomal | flavecins | Ruminococcus flavefaciens FD-1
BGC0002005.2 |  | 0.51 | ribosomal | RaxX | Xanthomonas oryzae pv. oryzae
BGC0002663.2 |  | 0.51 | ribosomal | amyloliquecidin GF610 | Bacillus amyloliquefaciens UMAF6639
BGC0000554.4 |  | 0.51 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001579.4 |  | 0.50 | ribosomal | duramycin | Streptomyces cinnamoneus
BGC0001210.5 |  | 0.50 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001229.4 |  | 0.61 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000517.4 |  | 0.60 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0002110.3 |  | 0.55 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0000528.5 |  | 0.55 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001311.5 |  | 0.52 | ribosomal | flavecins | Ruminococcus flavefaciens FD-1
BGC0002005.2 |  | 0.51 | ribosomal | RaxX | Xanthomonas oryzae pv. oryzae
BGC0002663.2 |  | 0.51 | ribosomal | amyloliquecidin GF610 | Bacillus amyloliquefaciens UMAF6639
BGC0000554.4 |  | 0.51 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001579.4 |  | 0.50 | ribosomal | duramycin | Streptomyces cinnamoneus
BGC0001210.5 |  | 0.50 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for MT347_RS12960

MT347_RS12955
Leader:
MTERNVSLLEEIAEQDQALTS
Core:
A G Q G W T T T I T S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C N
Core with dehydrations:
A G Q G W Dhb Dhb Dhb I Dhb Dha L Dhb Cys Y G V Dha W V A G N N G Q V Cys Dhb A Dhb V E Cys Q N N Cys N

#### antiSMASH-DB 4.0 matches for MT347_RS12955

100.0%
NZ_JALGRP010000007.1 and 1 other:
NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12955_lanthipeptide
Lanthipeptides: MT347_RS12955_lanthipeptide
1
A G Q G W T T T I T S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C N
39
A G Q G W T T T I T S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C N
1
A G Q G W T T T I T S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C N
39
66.7%
NZ_BMRY01000003.1 and 24 others:
NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12370_lanthipeptide NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptide NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptide NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptide NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptide NZ_CP021707.1 Lanthipeptides: CCZ36_RS18205_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide
Lanthipeptides: IE140_RS12370_lanthipeptide
2
G Q G W T T T I T S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C
38
G Q G W T ++S L+C Y G S+V G N N G C T A T E C Q N N C
1
G Q G W G T I V S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C
37
66.7%
NZ_CP116355.1 and 1 other:
NZ_CP116355.1 Lanthipeptides: KPP03845_RS17815_lanthipeptide
Lanthipeptides: KPP03845_RS17815_lanthipeptide
2
G Q G W T T T I T S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C
38
G Q G W T ++S L+C Y G S+V G N N G C T A T E C Q N N C
1
G Q G W G T V M S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C
37
with 97 more sequence matches
Only the first 10 are displayed here.
66.7%
NZ_WHOM01000078.1 and 1 other:
NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29300_lanthipeptide
Lanthipeptides: GCN81_RS29300_lanthipeptide
2
G Q G W T T T I T S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C
38
G Q G W T T++S L+C Y G S+V G N N G C T A T E C Q+N C
1
G Q G W G T T L S S L S C Y G A S Y V L G N N G N F C T A T A E C Q S N C
37
64.1%
NZ_QKTG01000020.1 and 1 other:
NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS16920_lanthipeptide
Lanthipeptides: DEI99_RS16920_lanthipeptide
3
Q G W T T T I T S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C N
39
Q G T T+T+L+C Y G V S W G N+G C T A T V E C Q+N C
1
Q G I G T T V T T L S C Y G V S W A L G N D G N F C T A T V E C Q S N C K
37
53.8%
NZ_LT575476.1 and 1 other:
NZ_LT575476.1 Lanthipeptides: BN6628_RS02285_lanthipeptide
Lanthipeptides: BN6628_RS02285_lanthipeptide
5
W T T T I T S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C N
39
W T +T+L C G S+ G+ G Q V C T A T V E C N N C
3
W G T V L T T L A C L G A S Y A L G D K G Q V C T A T V E C I N N C R
37
52.5%
NZ_JALIRS010000003.1 and 3 others:
NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07255_lanthipeptide NZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide NZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide
Lanthipeptides: MOK21_RS07255_lanthipeptide
3
Q G W T T T I-T S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C N
39
+ W T I T S L C S++ G N G V C T T V E C Q C N
3
E R W A E T I L T S L A C A A A S Y I L G N P G H V C T L T V E C Q K K C N
40
51.3%
NZ_CM000756.1 and 7 others:
NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS34475_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptide
Lanthipeptides: BTHUR0011_RS34475_lanthipeptide
5
W T T T I T S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C
38
W T T T S T +S G N G+V C T T V E C N N C
4
W N T T A T S-T S I I I S E T F G N K G K V C T Y T V E C V N N C
36
51.3%
NZ_CP017953.1 and 27 others:
NZ_CP017953.1 Lanthipeptides: BAMY_RS16400_lanthipeptide NZ_CP021011.1 Lanthipeptides: B6257_RS06480_lanthipeptide NZ_CP021011.1 Lanthipeptides: B6257_RS06480_lanthipeptide NZ_CP033054.1 Lanthipeptides: D9777_RS18850_lanthipeptide NZ_CP033054.1 Lanthipeptides: D9777_RS18850_lanthipeptide NZ_CP041784.1 Lanthipeptides: FOV14_RS15900_lanthipeptide NZ_CP041784.1 Lanthipeptides: FOV14_RS15900_lanthipeptide NZ_CP047268.1 Lanthipeptides: GKS41_RS18615_lanthipeptide NZ_CP047268.1 Lanthipeptides: GKS41_RS18615_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS05705_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS05705_lanthipeptide NZ_CP072563.1 Lanthipeptides: J6600_RS15945_lanthipeptide NZ_CP072563.1 Lanthipeptides: J6600_RS15945_lanthipeptide NZ_CP097326.1 Lanthipeptides: M5J22_RS16190_lanthipeptide NZ_CP097326.1 Lanthipeptides: M5J22_RS16190_lanthipeptide NZ_CP097784.1 Lanthipeptides: MF619_RS16160_lanthipeptide NZ_CP097784.1 Lanthipeptides: MF619_RS16160_lanthipeptide NZ_CP116014.1 Lanthipeptides: PF996_RS17895_lanthipeptide NZ_CP116014.1 Lanthipeptides: PF996_RS17895_lanthipeptide NZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11815_lanthipeptide NZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11815_lanthipeptide NZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12550_lanthipeptide NZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12550_lanthipeptide NZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01375_lanthipeptide NZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01375_lanthipeptide NZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06825_lanthipeptide NZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06825_lanthipeptide
Lanthipeptides: BAMY_RS16400_lanthipeptide
5
W T T T I T S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C
38
W T T T S L V S V G N G+V C T T E C Q C
4
W N T T T T S L G G I L V S E V L G N K G K V C T G T K E C Q G T C
37
51.3%
NZ_JAQFWW010000002.1 and 1 other:
NZ_JAQFWW010000002.1 Lanthipeptides: PDT38_RS11330_lanthipeptide
Lanthipeptides: PDT38_RS11330_lanthipeptide
5
W T T T I T S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C N
39
W T +T+L+C S + G+ G Q V C T T V E C Q N N C
3
W G T L L T T L S C L A A S I M I G D K G Q V C T G T V E C Q N N C R
37
48.7%
NZ_CP013862.1 and 1 other:
NZ_CP013862.1 Lanthipeptides: AOX59_RS09360_lanthipeptide
Lanthipeptides: AOX59_RS09360_lanthipeptide
7
T T I T S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C N
39
T +T T C+ +S G N+G +C T A T V E C Q N C N
6
T A L T Y S T C H W I S P A M G N D G H L C T A T V E C Q P N C N
38
48.7%
NZ_CP047645.1 and 7 others:
NZ_CP047645.1 Lanthipeptides: GSN02_RS17445_lanthipeptide NZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04860_lanthipeptide NZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04860_lanthipeptide NZ_NJRE01000008.1 Lanthipeptides: CE047_RS18560_lanthipeptide NZ_NJRE01000008.1 Lanthipeptides: CE047_RS18560_lanthipeptide NZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03725_lanthipeptide NZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03725_lanthipeptide
Lanthipeptides: GSN02_RS17445_lanthipeptide
5
W T T T I T S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C
38
W T T T S+ V S V G N G+V C T T E C Q C
4
W N T T T T S V G T I L V S E V F G N K G K V C T G T K E C Q G T C
37
48.7%
NZ_JAGKQT010000007.1 and 3 others:
NZ_JAGKQT010000007.1 Lanthipeptides: J2M30_RS09860_lanthipeptide NZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptide NZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptide
Lanthipeptides: J2M30_RS09860_lanthipeptide
8
T I T S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C
38
T I++ T C V S G N+G+V C T T V E C N N C
5
T I S T S T C I A V S H F V G N D G K V C T Y T V E C V N N C
35

#### MIBiG 4.0 matches for MT347_RS12955

35.9%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
15
Y G V S W V A G N N G Q V C T A T V E C Q N N C N
39
+ +S G N N G C T T E C Q N C N
6
F S L S N A L G N N G G W C T L T K E C Q P N C N
30
33.3%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
15
Y G V S W V A G N N G Q V C T A T V E C Q N N C N
39
Y +S G N G C T T V E C +C N
4
Y N I S C R L G N K G A Y C T L T V E C M P S C N
28
20.5%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
28
C T A T V E C Q N N C N
39
C T + E C Q N C N
28
C T L S K E C Q P N C N
39
MT347_RS12965
Leader:
MTTNTHNRTGFIAEDDLVLLSENAQDVSAG
Core:
T T T A P C A V A G L T I A A T A A L P G F C P T G A C T T R C T Q G
Core with dehydrations:
Dhb Dhb Dhb A P Cys A V A G L Dhb I A A Dhb A A L P G F Cys P Dhb G A Cys Dhb Dhb R Cys Dhb Q G

#### antiSMASH-DB 4.0 matches for MT347_RS12965

100.0%
NZ_JALGRP010000007.1 and 1 other:
NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12965_lanthipeptide
Lanthipeptides: MT347_RS12965_lanthipeptide
1
T T T A P C A V A G L T I A A T A A L P G F C P T G A C T T R C T Q G
35
T T T A P C A V A G L T I A A T A A L P G F C P T G A C T T R C T Q G
1
T T T A P C A V A G L T I A A T A A L P G F C P T G A C T T R C T Q G
35
68.6%
NZ_JACSPO010000013.1 and 1 other:
NZ_JACSPO010000013.1 Lanthipeptides: H9624_RS14885_lanthipeptide
Lanthipeptides: H9624_RS14885_lanthipeptide
1
T T T A P C A V A G L T I A A T A A L P G F C P T G A C T T R C
32
T T T P C A+ G I A +A A L P F C P T G A C T T R C
3
T T T V P C A I G G G V I A I S A A L P D F C P T G A C T T R C
34
45.7%
NZ_CP017762.1 and 3 others:
NZ_CP017762.1 Lanthipeptides: BKP57_RS21840_lanthipeptide NZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptide NZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptide
Lanthipeptides: BKP57_RS21840_lanthipeptide
1
T T T A P C A V A G L T I A A T A A L P G F C P T G A C T T R C T Q
34
T T T P C A V A +I A C P T A C+++C +
1
T T T V P C A V A A-S I A-------L C P T L A C S S K C G E
26
with 87 more sequence matches
Only the first 10 are displayed here.
45.7%
NZ_JAENHN010000066.1 and 1 other:
NZ_JAENHN010000066.1 Lanthipeptides: JHL18_RS24400_lanthipeptide
Lanthipeptides: JHL18_RS24400_lanthipeptide
5
P C A V---A G L T I A A T A A L P G F C P T G A C T T R C
32
P C A V G L T I A+ C T G A C T C
4
P C A V I A T V G L T I K V A T A V--V C E T G A C T G Y C
32
42.9%
NZ_NTSF01000026.1 and 1 other:
NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21840_lanthipeptide
Lanthipeptides: CN325_RS21840_lanthipeptide
1
T T T A P C A V A G L T I A A T A A L P G F C P T G A C T T R C
32
+T T P C + G T I + A +C P T C T R C
2
S T T V P C G I-G S T I T I S I A---Y C P T S K C T E R C
29
40.0%
NC_015215.1 and 5 others:
NC_015215.1 Lanthipeptides: SGGBAA2069_RS00700_lanthipeptide NZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09790_lanthipeptide NZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09790_lanthipeptide NZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05355_lanthipeptide NZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05355_lanthipeptide
Lanthipeptides: SGGBAA2069_RS00700_lanthipeptide
6
C A V A G L T-I A A T A A L P G F C P T G A C T T R C T Q
34
C A A ++ I+ +A L F T A C T T R C
5
C A W A A V S A I S T V S A L--F Q I T T A C T T R C Y H
32
40.0%
NZ_CM000721.1 and 9 others:
NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptide NZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide
Lanthipeptides: BCERE0010_RS29355_lanthipeptide
8
V A G L T I A A T A A L P G F C P T G A C T T R C
32
+ G T I A T A+L C P T C T+R C
14
I I G A T I A V T A S L---C P T T K C T S R C
35
40.0%
NZ_CP040938.1 and 1 other:
NZ_CP040938.1 Lanthipeptides: B5772_RS02455_lanthipeptide
Lanthipeptides: B5772_RS02455_lanthipeptide
1
T T T A P C A V A G L T I A A T A A L P G F C P T G A C T T R C
32
T T+ P C A V +A+T A C P T C+ +C
2
T T S I P C A V----M A S T A----I C P T L V C S N K C
25
40.0%
NZ_JABBGE010000004.1 and 1 other:
NZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13570_lanthipeptide
Lanthipeptides: HHL19_RS13570_lanthipeptide
2
T T A P C A V A G L T I A A T A A L P G F C P T G A C T T R C
32
T T C A V +T A T C P T C T++C
1
T T W S C A V--V T A V A T L V S A S A C P T T K C T S Q C
29
40.0%
NZ_JAENHN010000066.1 and 1 other:
NZ_JAENHN010000066.1 Lanthipeptides: JHL18_RS24410_lanthipeptide
Lanthipeptides: JHL18_RS24410_lanthipeptide
1
T T T A P C A V A G L T I A A T A A L P G F C P T G A C T T R C
32
T T T C A+ G L T+ + C P+ A C T C
2
T T T L A C A I T G L T V I V V T E V A--C P S K A C T G Y C
31
40.0%
NZ_QKTG01000020.1 and 1 other:
NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS08060_lanthipeptide
Lanthipeptides: DEI99_RS08060_lanthipeptide
16
T A A L P G F C P T G A C T T R C
32
+A A L P G F C P T G A C T++C
1
S A A L P G F C P T G A C T S K C
17
40.0%
NZ_QORY01000016.1 and 1 other:
NZ_QORY01000016.1 Lanthipeptides: DT250_RS18265_lanthipeptide
Lanthipeptides: DT250_RS18265_lanthipeptide
2
T T A P C A V A G L T I A A T A A L P G F C P T G A C T T R C
32
T T C A+ T I A+ A C P T A C+++C
8
T T W G C A I--F T I A S A A Q----C P T T A C S S K C
32
38.1%
NZ_NTSR01000029.1 and 1 other:
NZ_NTSR01000029.1 Lanthipeptides: CN358_RS25165_lanthipeptide
Lanthipeptides: CN358_RS25165_lanthipeptide
2
T T A P C A V----A G L T I A A T A A L P G F C P T G A C T T R C
32
T T P C A V G+T I C P T A C++R C
7
T T V P C A V G G A T V G I T I Y T F D R S H Q S C P T S A C S S R C
41

#### MIBiG 4.0 matches for MT347_RS12965

32.4%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
9
A G L T I A A T A A L P G F C P T G A C T T R C
32
A G+ + +A A F C P T C T+R C
17
A G V A V G V S A A---F C P T T K C T S R C
37
20.0%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
22
F C P T G A C T T R C
32
F C P T C T++C
16
F C P T T K C T S K C
26
20.0%
BGC0002130.3 (QKI29070.1):
Lanthipeptide: cacaoidin
2
T T A P C A V---A G L T I A A T A A L
19
++A P C + +I+A T A+
1
S S A P C T I Y A S V S A S I S A T A S W
21
allorf_190248_190481
Leader:
MGTARASRGAAPAPTGPRVRLTAAHVGGRRTGVRGA
Core:
A R P L F A A T A H V S L R P T R A P P K G Q T D V A D R R C R R C G P Q W K R S
Core with dehydrations:
A R P L F A A Dhb A H V Dha L R P Dhb R A P P K G Q Dhb D V A D R R Cys R R Cys G P Q W K R Dha

#### antiSMASH-DB 4.0 matches for allorf_190248_190481

100.0%
NZ_JALGRP010000007.1 and 1 other:
NZ_JALGRP010000007.1 Lanthipeptides: allorf_190248_190481_lanthipeptide
Lanthipeptides: allorf_190248_190481_lanthipeptide
1
A R P L F A A T A H V S L R P T R A P P K G Q T D V A D R R C R R C G P Q W K R S
41
A R P L F A A T A H V S L R P T R A P P K G Q T D V A D R R C R R C G P Q W K R S
1
A R P L F A A T A H V S L R P T R A P P K G Q T D V A D R R C R R C G P Q W K R S
41
19.5%
NZ_CP039292.1 and 1 other:
NZ_CP039292.1 Lanthipeptides: allorf_0076338_0076511_lanthipeptide
Lanthipeptides: allorf_0076338_0076511_lanthipeptide
21
K G Q T D V A D R R C R R C G P Q W K R S
41
+G V+D C+ C G P +K +
6
E G S G R V S D C L C K G C G P T Y K E T
26
allorf_190392_190544
Leader:
MGTLRCGERRPRPRRSSVSGA
Core:
S G T F P L G A A A S T P T I G H I R L A L R R C T C G P
Core with dehydrations:
Dha G Dhb F P L G A A A Dha Dhb P Dhb I G H I R L A L R R Cys Dhb Cys G P

#### antiSMASH-DB 4.0 matches for allorf_190392_190544

100.0%
NZ_JALGRP010000007.1 and 1 other:
NZ_JALGRP010000007.1 Lanthipeptides: allorf_190392_190544_lanthipeptide
Lanthipeptides: allorf_190392_190544_lanthipeptide
1
S G T F P L G A A A S T P T I G H I R L A L R R C T C G P
29
S G T F P L G A A A S T P T I G H I R L A L R R C T C G P
1
S G T F P L G A A A S T P T I G H I R L A L R R C T C G P
29
23.4%
NZ_BNBI01000017.1:
Lanthipeptides: allorf_050255_050446_lanthipeptide
5
P L G A A A S T P T I G H I R L A L R R C T C G P
29
P G A A A T P+ + L+R C P
1
P Q G A A A R T P S--R V H F G L Q R P V C L P
23
20.7%
NZ_LMSL01000013.1:
Lanthipeptides: allorf_11540_11626_lanthipeptide
20
L A L R R C T C G P
29
L++R C C G P
4
L S I R L C N C G P
13
with 1 more sequence matches
14.0%
NZ_AZVD01000036.1 and 1 other:
NZ_KB898432.1 Lanthipeptides: allorf_07386_07619_lanthipeptide
Lanthipeptides: allorf_19664_19897_lanthipeptide
8
A A A S T P T I G H I R
19
A S+P +G H+R
17
A L P S S P H L G H L R
28
allorf_201135_201245
Leader:
MEGERMPGV
Core:
S A S A P L S C R A A R R A P G G H C L R S G D A P I
Core with dehydrations:
Dha A Dha A P L Dha Cys R A A R R A P G G H Cys L R Dha G D A P I

#### antiSMASH-DB 4.0 matches for allorf_201135_201245

100.0%
NZ_JALGRP010000007.1 and 1 other:
NZ_JALGRP010000007.1 Lanthipeptides: allorf_201135_201245_lanthipeptide
Lanthipeptides: allorf_201135_201245_lanthipeptide
1
S A S A P L S C R A A R R A P G G H C L R S G D A P I
27
S A S A P L S C R A A R R A P G G H C L R S G D A P I
1
S A S A P L S C R A A R R A P G G H C L R S G D A P I
27
35.7%
NZ_CP011130.1 and 4 others:
NZ_CP023465.1 Lanthipeptides: CNO08_RS25790_lanthipeptide NZ_CP076103.1 Lanthipeptides: KME82_RS10615_lanthipeptide NZ_CP094357.1 Lanthipeptides: IEQ11_RS10290_lanthipeptide NZ_KQ061217.1 Lanthipeptides: WN54_RS27350_lanthipeptide
Lanthipeptides: LC55x_RS27745_lanthipeptide
1
S A S A P L S C R A A R R A P G G H C L R S G D A P I
27
S S+ C + + G G C L S G+ I
1
S T S S F A G C N C S T S S N G G-C L C S G E V T I
26
31.2%
NZ_MUXN01000027.1:
Lanthipeptides: allorf_018463_018597_lanthipeptide
12
R R A P G G H C L R S G-D A P I
27
R R A P G R G D A P+
2
R R A P A G R S R R C G D D A P V
18
with 4 more sequence matches
25.7%
NZ_LMEQ01000012.1:
Lanthipeptides: allorf_0979470_0979679_lanthipeptide
6
L S C R A A R R A P G G H C L R S G D A P I
27
L+C R R H R S D P+
5
L A C R G E V R P Q L V H R E R S P D R P V
26
20.5%
NZ_VXKQ01000008.1:
Lanthipeptides: F3D62_RS12715_lanthipeptide
9
R A A R R A P G G H C L R S G D
24
A A P G G H C + D
20
N A T L T A P G G H C T E T T D
35
13.5%
NZ_CP007597.1:
Lanthipeptides: allorf_2301019_2301156_lanthipeptide
16
G G H C L R
21
G G H C+R
23
G G H C I R
28
10.4%
NZ_CP086102.1 and 1 other:
NZ_KZ195572.1 Lanthipeptides: allorf_6130947_6131129_lanthipeptide
Lanthipeptides: allorf_6120061_6120243_lanthipeptide
19
C L R S G D A P
26
C+R+G+A P
10
C I R T G E A P
17

#### MIBiG 4.0 matches for allorf_201135_201245

9.8%
BGC0002120.3 (NQE92413.1):
Lanthipeptide: nocathioamide A
14
A P G G H C L R S
22
A P H L S
37
A P A C H T L S S
45

#### Lanthipeptide(s) for MT347_RS12970

MT347_RS12955
Leader:
MTERNVSLLEEIAEQDQALTS
Core:
A G Q G W T T T I T S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C N
Core with dehydrations:
A G Q G W Dhb Dhb Dhb I Dhb Dha L Dhb Cys Y G V Dha W V A G N N G Q V Cys Dhb A Dhb V E Cys Q N N Cys N

#### antiSMASH-DB 4.0 matches for MT347_RS12955

100.0%
NZ_JALGRP010000007.1 and 1 other:
NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12955_lanthipeptide
Lanthipeptides: MT347_RS12955_lanthipeptide
1
A G Q G W T T T I T S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C N
39
A G Q G W T T T I T S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C N
1
A G Q G W T T T I T S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C N
39
66.7%
NZ_BMRY01000003.1 and 24 others:
NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12370_lanthipeptide NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptide NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptide NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptide NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptide NZ_CP021707.1 Lanthipeptides: CCZ36_RS18205_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide
Lanthipeptides: IE140_RS12370_lanthipeptide
2
G Q G W T T T I T S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C
38
G Q G W T ++S L+C Y G S+V G N N G C T A T E C Q N N C
1
G Q G W G T I V S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C
37
66.7%
NZ_CP116355.1 and 1 other:
NZ_CP116355.1 Lanthipeptides: KPP03845_RS17815_lanthipeptide
Lanthipeptides: KPP03845_RS17815_lanthipeptide
2
G Q G W T T T I T S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C
38
G Q G W T ++S L+C Y G S+V G N N G C T A T E C Q N N C
1
G Q G W G T V M S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C
37
with 97 more sequence matches
Only the first 10 are displayed here.
66.7%
NZ_WHOM01000078.1 and 1 other:
NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29300_lanthipeptide
Lanthipeptides: GCN81_RS29300_lanthipeptide
2
G Q G W T T T I T S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C
38
G Q G W T T++S L+C Y G S+V G N N G C T A T E C Q+N C
1
G Q G W G T T L S S L S C Y G A S Y V L G N N G N F C T A T A E C Q S N C
37
64.1%
NZ_QKTG01000020.1 and 1 other:
NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS16920_lanthipeptide
Lanthipeptides: DEI99_RS16920_lanthipeptide
3
Q G W T T T I T S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C N
39
Q G T T+T+L+C Y G V S W G N+G C T A T V E C Q+N C
1
Q G I G T T V T T L S C Y G V S W A L G N D G N F C T A T V E C Q S N C K
37
53.8%
NZ_LT575476.1 and 1 other:
NZ_LT575476.1 Lanthipeptides: BN6628_RS02285_lanthipeptide
Lanthipeptides: BN6628_RS02285_lanthipeptide
5
W T T T I T S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C N
39
W T +T+L C G S+ G+ G Q V C T A T V E C N N C
3
W G T V L T T L A C L G A S Y A L G D K G Q V C T A T V E C I N N C R
37
52.5%
NZ_JALIRS010000003.1 and 3 others:
NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07255_lanthipeptide NZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide NZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide
Lanthipeptides: MOK21_RS07255_lanthipeptide
3
Q G W T T T I-T S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C N
39
+ W T I T S L C S++ G N G V C T T V E C Q C N
3
E R W A E T I L T S L A C A A A S Y I L G N P G H V C T L T V E C Q K K C N
40
51.3%
NZ_CM000756.1 and 7 others:
NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS34475_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS30450_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS29770_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS30260_lanthipeptide
Lanthipeptides: BTHUR0011_RS34475_lanthipeptide
5
W T T T I T S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C
38
W T T T S T +S G N G+V C T T V E C N N C
4
W N T T A T S-T S I I I S E T F G N K G K V C T Y T V E C V N N C
36
51.3%
NZ_CP017953.1 and 27 others:
NZ_CP017953.1 Lanthipeptides: BAMY_RS16400_lanthipeptide NZ_CP021011.1 Lanthipeptides: B6257_RS06480_lanthipeptide NZ_CP021011.1 Lanthipeptides: B6257_RS06480_lanthipeptide NZ_CP033054.1 Lanthipeptides: D9777_RS18850_lanthipeptide NZ_CP033054.1 Lanthipeptides: D9777_RS18850_lanthipeptide NZ_CP041784.1 Lanthipeptides: FOV14_RS15900_lanthipeptide NZ_CP041784.1 Lanthipeptides: FOV14_RS15900_lanthipeptide NZ_CP047268.1 Lanthipeptides: GKS41_RS18615_lanthipeptide NZ_CP047268.1 Lanthipeptides: GKS41_RS18615_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS05705_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS05705_lanthipeptide NZ_CP072563.1 Lanthipeptides: J6600_RS15945_lanthipeptide NZ_CP072563.1 Lanthipeptides: J6600_RS15945_lanthipeptide NZ_CP097326.1 Lanthipeptides: M5J22_RS16190_lanthipeptide NZ_CP097326.1 Lanthipeptides: M5J22_RS16190_lanthipeptide NZ_CP097784.1 Lanthipeptides: MF619_RS16160_lanthipeptide NZ_CP097784.1 Lanthipeptides: MF619_RS16160_lanthipeptide NZ_CP116014.1 Lanthipeptides: PF996_RS17895_lanthipeptide NZ_CP116014.1 Lanthipeptides: PF996_RS17895_lanthipeptide NZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11815_lanthipeptide NZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11815_lanthipeptide NZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12550_lanthipeptide NZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12550_lanthipeptide NZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01375_lanthipeptide NZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01375_lanthipeptide NZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06825_lanthipeptide NZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06825_lanthipeptide
Lanthipeptides: BAMY_RS16400_lanthipeptide
5
W T T T I T S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C
38
W T T T S L V S V G N G+V C T T E C Q C
4
W N T T T T S L G G I L V S E V L G N K G K V C T G T K E C Q G T C
37
51.3%
NZ_JAQFWW010000002.1 and 1 other:
NZ_JAQFWW010000002.1 Lanthipeptides: PDT38_RS11330_lanthipeptide
Lanthipeptides: PDT38_RS11330_lanthipeptide
5
W T T T I T S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C N
39
W T +T+L+C S + G+ G Q V C T T V E C Q N N C
3
W G T L L T T L S C L A A S I M I G D K G Q V C T G T V E C Q N N C R
37
48.7%
NZ_CP013862.1 and 1 other:
NZ_CP013862.1 Lanthipeptides: AOX59_RS09360_lanthipeptide
Lanthipeptides: AOX59_RS09360_lanthipeptide
7
T T I T S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C N
39
T +T T C+ +S G N+G +C T A T V E C Q N C N
6
T A L T Y S T C H W I S P A M G N D G H L C T A T V E C Q P N C N
38
48.7%
NZ_CP047645.1 and 7 others:
NZ_CP047645.1 Lanthipeptides: GSN02_RS17445_lanthipeptide NZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04860_lanthipeptide NZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04860_lanthipeptide NZ_NJRE01000008.1 Lanthipeptides: CE047_RS18560_lanthipeptide NZ_NJRE01000008.1 Lanthipeptides: CE047_RS18560_lanthipeptide NZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03725_lanthipeptide NZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03725_lanthipeptide
Lanthipeptides: GSN02_RS17445_lanthipeptide
5
W T T T I T S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C
38
W T T T S+ V S V G N G+V C T T E C Q C
4
W N T T T T S V G T I L V S E V F G N K G K V C T G T K E C Q G T C
37
48.7%
NZ_JAGKQT010000007.1 and 3 others:
NZ_JAGKQT010000007.1 Lanthipeptides: J2M30_RS09860_lanthipeptide NZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptide NZ_LVYL01000010.1 Lanthipeptides: A3863_RS05855_lanthipeptide
Lanthipeptides: J2M30_RS09860_lanthipeptide
8
T I T S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C
38
T I++ T C V S G N+G+V C T T V E C N N C
5
T I S T S T C I A V S H F V G N D G K V C T Y T V E C V N N C
35

#### MIBiG 4.0 matches for MT347_RS12955

35.9%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
15
Y G V S W V A G N N G Q V C T A T V E C Q N N C N
39
+ +S G N N G C T T E C Q N C N
6
F S L S N A L G N N G G W C T L T K E C Q P N C N
30
33.3%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
15
Y G V S W V A G N N G Q V C T A T V E C Q N N C N
39
Y +S G N G C T T V E C +C N
4
Y N I S C R L G N K G A Y C T L T V E C M P S C N
28
20.5%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
28
C T A T V E C Q N N C N
39
C T + E C Q N C N
28
C T L S K E C Q P N C N
39
MT347_RS12965
Leader:
MTTNTHNRTGFIAEDDLVLLSENAQDVSAG
Core:
T T T A P C A V A G L T I A A T A A L P G F C P T G A C T T R C T Q G
Core with dehydrations:
Dhb Dhb Dhb A P Cys A V A G L Dhb I A A Dhb A A L P G F Cys P Dhb G A Cys Dhb Dhb R Cys Dhb Q G

#### antiSMASH-DB 4.0 matches for MT347_RS12965

100.0%
NZ_JALGRP010000007.1 and 1 other:
NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12965_lanthipeptide
Lanthipeptides: MT347_RS12965_lanthipeptide
1
T T T A P C A V A G L T I A A T A A L P G F C P T G A C T T R C T Q G
35
T T T A P C A V A G L T I A A T A A L P G F C P T G A C T T R C T Q G
1
T T T A P C A V A G L T I A A T A A L P G F C P T G A C T T R C T Q G
35
68.6%
NZ_JACSPO010000013.1 and 1 other:
NZ_JACSPO010000013.1 Lanthipeptides: H9624_RS14885_lanthipeptide
Lanthipeptides: H9624_RS14885_lanthipeptide
1
T T T A P C A V A G L T I A A T A A L P G F C P T G A C T T R C
32
T T T P C A+ G I A +A A L P F C P T G A C T T R C
3
T T T V P C A I G G G V I A I S A A L P D F C P T G A C T T R C
34
45.7%
NZ_CP017762.1 and 3 others:
NZ_CP017762.1 Lanthipeptides: BKP57_RS21840_lanthipeptide NZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptide NZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptide
Lanthipeptides: BKP57_RS21840_lanthipeptide
1
T T T A P C A V A G L T I A A T A A L P G F C P T G A C T T R C T Q
34
T T T P C A V A +I A C P T A C+++C +
1
T T T V P C A V A A-S I A-------L C P T L A C S S K C G E
26
with 87 more sequence matches
Only the first 10 are displayed here.
45.7%
NZ_JAENHN010000066.1 and 1 other:
NZ_JAENHN010000066.1 Lanthipeptides: JHL18_RS24400_lanthipeptide
Lanthipeptides: JHL18_RS24400_lanthipeptide
5
P C A V---A G L T I A A T A A L P G F C P T G A C T T R C
32
P C A V G L T I A+ C T G A C T C
4
P C A V I A T V G L T I K V A T A V--V C E T G A C T G Y C
32
42.9%
NZ_NTSF01000026.1 and 1 other:
NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21840_lanthipeptide
Lanthipeptides: CN325_RS21840_lanthipeptide
1
T T T A P C A V A G L T I A A T A A L P G F C P T G A C T T R C
32
+T T P C + G T I + A +C P T C T R C
2
S T T V P C G I-G S T I T I S I A---Y C P T S K C T E R C
29
40.0%
NC_015215.1 and 5 others:
NC_015215.1 Lanthipeptides: SGGBAA2069_RS00700_lanthipeptide NZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09790_lanthipeptide NZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09790_lanthipeptide NZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05355_lanthipeptide NZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05355_lanthipeptide
Lanthipeptides: SGGBAA2069_RS00700_lanthipeptide
6
C A V A G L T-I A A T A A L P G F C P T G A C T T R C T Q
34
C A A ++ I+ +A L F T A C T T R C
5
C A W A A V S A I S T V S A L--F Q I T T A C T T R C Y H
32
40.0%
NZ_CM000721.1 and 9 others:
NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptide NZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide
Lanthipeptides: BCERE0010_RS29355_lanthipeptide
8
V A G L T I A A T A A L P G F C P T G A C T T R C
32
+ G T I A T A+L C P T C T+R C
14
I I G A T I A V T A S L---C P T T K C T S R C
35
40.0%
NZ_CP040938.1 and 1 other:
NZ_CP040938.1 Lanthipeptides: B5772_RS02455_lanthipeptide
Lanthipeptides: B5772_RS02455_lanthipeptide
1
T T T A P C A V A G L T I A A T A A L P G F C P T G A C T T R C
32
T T+ P C A V +A+T A C P T C+ +C
2
T T S I P C A V----M A S T A----I C P T L V C S N K C
25
40.0%
NZ_JABBGE010000004.1 and 1 other:
NZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13570_lanthipeptide
Lanthipeptides: HHL19_RS13570_lanthipeptide
2
T T A P C A V A G L T I A A T A A L P G F C P T G A C T T R C
32
T T C A V +T A T C P T C T++C
1
T T W S C A V--V T A V A T L V S A S A C P T T K C T S Q C
29
40.0%
NZ_JAENHN010000066.1 and 1 other:
NZ_JAENHN010000066.1 Lanthipeptides: JHL18_RS24410_lanthipeptide
Lanthipeptides: JHL18_RS24410_lanthipeptide
1
T T T A P C A V A G L T I A A T A A L P G F C P T G A C T T R C
32
T T T C A+ G L T+ + C P+ A C T C
2
T T T L A C A I T G L T V I V V T E V A--C P S K A C T G Y C
31
40.0%
NZ_QKTG01000020.1 and 1 other:
NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS08060_lanthipeptide
Lanthipeptides: DEI99_RS08060_lanthipeptide
16
T A A L P G F C P T G A C T T R C
32
+A A L P G F C P T G A C T++C
1
S A A L P G F C P T G A C T S K C
17
40.0%
NZ_QORY01000016.1 and 1 other:
NZ_QORY01000016.1 Lanthipeptides: DT250_RS18265_lanthipeptide
Lanthipeptides: DT250_RS18265_lanthipeptide
2
T T A P C A V A G L T I A A T A A L P G F C P T G A C T T R C
32
T T C A+ T I A+ A C P T A C+++C
8
T T W G C A I--F T I A S A A Q----C P T T A C S S K C
32
38.1%
NZ_NTSR01000029.1 and 1 other:
NZ_NTSR01000029.1 Lanthipeptides: CN358_RS25165_lanthipeptide
Lanthipeptides: CN358_RS25165_lanthipeptide
2
T T A P C A V----A G L T I A A T A A L P G F C P T G A C T T R C
32
T T P C A V G+T I C P T A C++R C
7
T T V P C A V G G A T V G I T I Y T F D R S H Q S C P T S A C S S R C
41

#### MIBiG 4.0 matches for MT347_RS12965

32.4%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
9
A G L T I A A T A A L P G F C P T G A C T T R C
32
A G+ + +A A F C P T C T+R C
17
A G V A V G V S A A---F C P T T K C T S R C
37
20.0%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
22
F C P T G A C T T R C
32
F C P T C T++C
16
F C P T T K C T S K C
26
20.0%
BGC0002130.3 (QKI29070.1):
Lanthipeptide: cacaoidin
2
T T A P C A V---A G L T I A A T A A L
19
++A P C + +I+A T A+
1
S S A P C T I Y A S V S A S I S A T A S W
21
allorf_190248_190481
Leader:
MGTARASRGAAPAPTGPRVRLTAAHVGGRRTGVRGA
Core:
A R P L F A A T A H V S L R P T R A P P K G Q T D V A D R R C R R C G P Q W K R S
Core with dehydrations:
A R P L F A A Dhb A H V Dha L R P Dhb R A P P K G Q Dhb D V A D R R Cys R R Cys G P Q W K R Dha

#### antiSMASH-DB 4.0 matches for allorf_190248_190481

100.0%
NZ_JALGRP010000007.1 and 1 other:
NZ_JALGRP010000007.1 Lanthipeptides: allorf_190248_190481_lanthipeptide
Lanthipeptides: allorf_190248_190481_lanthipeptide
1
A R P L F A A T A H V S L R P T R A P P K G Q T D V A D R R C R R C G P Q W K R S
41
A R P L F A A T A H V S L R P T R A P P K G Q T D V A D R R C R R C G P Q W K R S
1
A R P L F A A T A H V S L R P T R A P P K G Q T D V A D R R C R R C G P Q W K R S
41
19.5%
NZ_CP039292.1 and 1 other:
NZ_CP039292.1 Lanthipeptides: allorf_0076338_0076511_lanthipeptide
Lanthipeptides: allorf_0076338_0076511_lanthipeptide
21
K G Q T D V A D R R C R R C G P Q W K R S
41
+G V+D C+ C G P +K +
6
E G S G R V S D C L C K G C G P T Y K E T
26
allorf_190392_190544
Leader:
MGTLRCGERRPRPRRSSVSGA
Core:
S G T F P L G A A A S T P T I G H I R L A L R R C T C G P
Core with dehydrations:
Dha G Dhb F P L G A A A Dha Dhb P Dhb I G H I R L A L R R Cys Dhb Cys G P

#### antiSMASH-DB 4.0 matches for allorf_190392_190544

100.0%
NZ_JALGRP010000007.1 and 1 other:
NZ_JALGRP010000007.1 Lanthipeptides: allorf_190392_190544_lanthipeptide
Lanthipeptides: allorf_190392_190544_lanthipeptide
1
S G T F P L G A A A S T P T I G H I R L A L R R C T C G P
29
S G T F P L G A A A S T P T I G H I R L A L R R C T C G P
1
S G T F P L G A A A S T P T I G H I R L A L R R C T C G P
29
23.4%
NZ_BNBI01000017.1:
Lanthipeptides: allorf_050255_050446_lanthipeptide
5
P L G A A A S T P T I G H I R L A L R R C T C G P
29
P G A A A T P+ + L+R C P
1
P Q G A A A R T P S--R V H F G L Q R P V C L P
23
20.7%
NZ_LMSL01000013.1:
Lanthipeptides: allorf_11540_11626_lanthipeptide
20
L A L R R C T C G P
29
L++R C C G P
4
L S I R L C N C G P
13
with 1 more sequence matches
14.0%
NZ_AZVD01000036.1 and 1 other:
NZ_KB898432.1 Lanthipeptides: allorf_07386_07619_lanthipeptide
Lanthipeptides: allorf_19664_19897_lanthipeptide
8
A A A S T P T I G H I R
19
A S+P +G H+R
17
A L P S S P H L G H L R
28
allorf_201135_201245
Leader:
MEGERMPGV
Core:
S A S A P L S C R A A R R A P G G H C L R S G D A P I
Core with dehydrations:
Dha A Dha A P L Dha Cys R A A R R A P G G H Cys L R Dha G D A P I

#### antiSMASH-DB 4.0 matches for allorf_201135_201245

100.0%
NZ_JALGRP010000007.1 and 1 other:
NZ_JALGRP010000007.1 Lanthipeptides: allorf_201135_201245_lanthipeptide
Lanthipeptides: allorf_201135_201245_lanthipeptide
1
S A S A P L S C R A A R R A P G G H C L R S G D A P I
27
S A S A P L S C R A A R R A P G G H C L R S G D A P I
1
S A S A P L S C R A A R R A P G G H C L R S G D A P I
27
35.7%
NZ_CP011130.1 and 4 others:
NZ_CP023465.1 Lanthipeptides: CNO08_RS25790_lanthipeptide NZ_CP076103.1 Lanthipeptides: KME82_RS10615_lanthipeptide NZ_CP094357.1 Lanthipeptides: IEQ11_RS10290_lanthipeptide NZ_KQ061217.1 Lanthipeptides: WN54_RS27350_lanthipeptide
Lanthipeptides: LC55x_RS27745_lanthipeptide
1
S A S A P L S C R A A R R A P G G H C L R S G D A P I
27
S S+ C + + G G C L S G+ I
1
S T S S F A G C N C S T S S N G G-C L C S G E V T I
26
31.2%
NZ_MUXN01000027.1:
Lanthipeptides: allorf_018463_018597_lanthipeptide
12
R R A P G G H C L R S G-D A P I
27
R R A P G R G D A P+
2
R R A P A G R S R R C G D D A P V
18
with 4 more sequence matches
25.7%
NZ_LMEQ01000012.1:
Lanthipeptides: allorf_0979470_0979679_lanthipeptide
6
L S C R A A R R A P G G H C L R S G D A P I
27
L+C R R H R S D P+
5
L A C R G E V R P Q L V H R E R S P D R P V
26
20.5%
NZ_VXKQ01000008.1:
Lanthipeptides: F3D62_RS12715_lanthipeptide
9
R A A R R A P G G H C L R S G D
24
A A P G G H C + D
20
N A T L T A P G G H C T E T T D
35
13.5%
NZ_CP007597.1:
Lanthipeptides: allorf_2301019_2301156_lanthipeptide
16
G G H C L R
21
G G H C+R
23
G G H C I R
28
10.4%
NZ_CP086102.1 and 1 other:
NZ_KZ195572.1 Lanthipeptides: allorf_6130947_6131129_lanthipeptide
Lanthipeptides: allorf_6120061_6120243_lanthipeptide
19
C L R S G D A P
26
C+R+G+A P
10
C I R T G E A P
17

#### MIBiG 4.0 matches for allorf_201135_201245

9.8%
BGC0002120.3 (NQE92413.1):
Lanthipeptide: nocathioamide A
14
A P G G H C L R S
22
A P H L S
37
A P A C H T L S S
45

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.26 out of 19.26
Confidence: medium
Additional weak hits (6):
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 18.61 out of 30.97
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.90 out of 28.19
Confidence: weak
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.01 out of 27.04
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 18.93 out of 36.54
Confidence: weak
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.30 out of 21.84
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 20.85 out of 35.63
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

MT347_RS12955 - Class II
  Cleavage pHMM score: -7.00
  RODEO score: 0
  Monoisotopic mass: 3888.8 Da
  Molecular weight: 3891.2 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3909.2 Da N = 1
    3927.3 Da N = 2
    3945.3 Da N = 3
    3963.3 Da N = 4
    3981.3 Da N = 5
MT347_RS12965 - Class II
  Cleavage pHMM score: -4.80
  RODEO score: 0
  Monoisotopic mass: 3134.6 Da
  Molecular weight: 3136.6 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3154.6 Da N = 1
    3172.6 Da N = 2
    3190.7 Da N = 3
    3208.7 Da N = 4
    3226.7 Da N = 5
allorf_190248_190481 - Class II
  Cleavage pHMM score: -4.30
  RODEO score: 0
  Monoisotopic mass: 4522.4 Da
  Molecular weight: 4525.2 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4543.2 Da N = 1
    4561.2 Da N = 2
    4579.2 Da N = 3
allorf_190392_190544 - Class II
  Cleavage pHMM score: -2.00
  RODEO score: 0
  Monoisotopic mass: 2815.5 Da
  Molecular weight: 2817.3 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2835.3 Da N = 1
    2853.3 Da N = 2
    2871.3 Da N = 3
    2889.4 Da N = 4
allorf_201135_201245 - Class II
  Cleavage pHMM score: -5.00
  RODEO score: 0
  Monoisotopic mass: 2604.3 Da
  Molecular weight: 2605.9 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2624.0 Da N = 1
    2642.0 Da N = 2
MT347_RS12955 - Class II
  Cleavage pHMM score: -7.00
  RODEO score: 0
  Monoisotopic mass: 3888.8 Da
  Molecular weight: 3891.2 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3909.2 Da N = 1
    3927.3 Da N = 2
    3945.3 Da N = 3
    3963.3 Da N = 4
    3981.3 Da N = 5
MT347_RS12965 - Class II
  Cleavage pHMM score: -4.80
  RODEO score: 0
  Monoisotopic mass: 3134.6 Da
  Molecular weight: 3136.6 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3154.6 Da N = 1
    3172.6 Da N = 2
    3190.7 Da N = 3
    3208.7 Da N = 4
    3226.7 Da N = 5
allorf_190248_190481 - Class II
  Cleavage pHMM score: -4.30
  RODEO score: 0
  Monoisotopic mass: 4522.4 Da
  Molecular weight: 4525.2 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4543.2 Da N = 1
    4561.2 Da N = 2
    4579.2 Da N = 3
allorf_190392_190544 - Class II
  Cleavage pHMM score: -2.00
  RODEO score: 0
  Monoisotopic mass: 2815.5 Da
  Molecular weight: 2817.3 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2835.3 Da N = 1
    2853.3 Da N = 2
    2871.3 Da N = 3
    2889.4 Da N = 4
allorf_201135_201245 - Class II
  Cleavage pHMM score: -5.00
  RODEO score: 0
  Monoisotopic mass: 2604.3 Da
  Molecular weight: 2605.9 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2624.0 Da N = 1
    2642.0 Da N = 2

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein

NZ_JALGRP010000008.1 - Region 1 - NAPAA
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 104,735 - 138,679 nt. (total: 33,945 nt) Show pHMM detection rules used
NAPAA: (AMP-binding and TIGR02353)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
MT347_RS13505: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Hydrolases: dehalogenase
MT347_RS13500: haloalkane dehalogenase

smcogs
  SMCOG1262: haloalkane dehalogenase

Isomerases: mutase
MT347_RS13640: phosphoglycerate mutase

smcogs
  SMCOG1101: phosphoglycerate mutase

Ligases: ligase
MT347_RS13580: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NAPAA | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002174.2 |  | 0.77 | NRPS | ε-Poly-L-lysine | Epichloe festucae
BGC0001135.5 |  | 0.61 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001249.5 |  | 0.60 | NRPS | dimethylcoprogen | Alternaria alternata
BGC0001250.4 |  | 0.60 | NRPS | epichloenin A | Epichloe festucae
BGC0001251.4 |  | 0.60 | NRPS | epichloenin A | Epichloe festucae
BGC0001833.4 |  | 0.59 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001240.4 |  | 0.59 | NRPS | serinocyclin A, serinocyclin B | Metarhizium robertsii
BGC0002286.3 |  | 0.59 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001166.5 |  | 0.59 | NRPS | HC-toxin | Alternaria jesenskae
BGC0001641.4 |  | 0.59 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002174.2 |  | 0.77 | NRPS | ε-Poly-L-lysine | Epichloe festucae
BGC0001135.5 |  | 0.61 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001249.5 |  | 0.60 | NRPS | dimethylcoprogen | Alternaria alternata
BGC0001250.4 |  | 0.60 | NRPS | epichloenin A | Epichloe festucae
BGC0001251.4 |  | 0.60 | NRPS | epichloenin A | Epichloe festucae
BGC0001833.4 |  | 0.59 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001240.4 |  | 0.59 | NRPS | serinocyclin A, serinocyclin B | Metarhizium robertsii
BGC0002286.3 |  | 0.59 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001166.5 |  | 0.59 | NRPS | HC-toxin | Alternaria jesenskae
BGC0001641.4 |  | 0.59 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
No hits above weak threshold.
Weak hits (9):
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.67 out of 27.78
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 20.45 out of 30.97
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 24.23 out of 36.53
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 24.31 out of 36.53
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 16.77 out of 26.06
Confidence: weak
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.73 out of 18.57
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.83 out of 28.14
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.37 out of 28.19
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 18.31 out of 33.14
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 104734 - 138679:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
MT347_RS13580: X
AMP-binding (29..418): X
nrpys: (unknown)

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    FAELFDASCEELSTIFGGEWNTYGPTEATVVACA
  Nearest Stachelhaus code(s):
    Lys DAEDIGTVVK (71% 8Å match)
    Gln or Tyr DAESVGTVVK (65% 8Å match)
  Stachelhaus code match:
    90% (moderate)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
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