GCF_022748615.1 - 38 region(s)

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Location: 50,666 - 90,172 nt. (total: 39,507 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: esterase

MQC87_RS37545: enterobactin/ferric enterobactin esterase

smcogs: SMCOG1098: enterobactin/ferric enterobactin esterase

Isomerases: mutase

MQC87_RS00310: phosphoglycerate mutase

smcogs: SMCOG1101: phosphoglycerate mutase

Ligases: ligase

MQC87_RS00405: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

MQC87_RS00410: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

MQC87_RS00415: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

MQC87_RS00420: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

MQC87_RS00435: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002075.3	0.75	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001132.4	0.71	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.71	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.71	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0000342.4	0.69	NRPS	enniatin	Fusarium equiseti
BGC0001758.4	0.69	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002286.3	0.69	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2	0.69	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001250.4	0.68	NRPS	epichloenin A	Epichloe festucae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002075.3	0.75	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001132.4	0.71	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.71	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.71	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0000342.4	0.69	NRPS	enniatin	Fusarium equiseti
BGC0001758.4	0.69	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002286.3	0.69	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2	0.69	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001250.4	0.68	NRPS	epichloenin A	Epichloe festucae

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.60 out of 19.26

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 28.73 out of 36.53

Confidence: medium

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 22.54 out of 27.04

Confidence: medium

Additional weak hits (13):

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.88 out of 39.62

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.61 out of 39.62

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.32 out of 39.62

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.23 out of 39.62

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 16.41 out of 31.73

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.85 out of 27.78

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 15.86 out of 31.73

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 18.61 out of 30.97

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.29 out of 26.06

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 16.71 out of 29.25

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 16.89 out of 30.97

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.22 out of 20.97

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 15.58 out of 33.14

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 50665 - 90172:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Lys) + (Ser) + (Gly)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

MQC87_RS00405: Lys

Search NORINE for peptide: strict or relaxed

AMP-binding (489..914): Lys

nrpys: Lys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: RWMAFDTHAEEPDLILGADVNSYGPTETTVIAAT
Nearest Stachelhaus code(s):: Lys DTEDIGSVIK (74% 8Å match)
Stachelhaus code match:: 100% (strong)

MQC87_RS00410: Ser

Search NORINE for peptide: strict or relaxed

AMP-binding (517..918): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWMTFDVSVWELHFVCSGEANLYGPTEAAVDVTS
Nearest Stachelhaus code(s):: Ser DVWHVSLVDK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

MQC87_RS00415: X

AMP-binding (38..439): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: GLDFTNAGQTMNFLGSTAAVNYYTSTEAAPAQIT
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

MQC87_RS00420: Gly

Search NORINE for peptide: strict or relaxed

AMP-binding (452..853): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: LALTFDISTVELQALAGGEINVYGPTETTVWSTL
Nearest Stachelhaus code(s):: Gly DILQLGVVWK (74% 8Å match)
Stachelhaus code match:: 90% (moderate)

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
DasR	N-acetylglucosamine dependent repressor
DmdR1	Iron(II)-dependent repressor

NZ_JALDPQ010000035.1 - Region 1 - NRPS,melanin

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Location: 1 - 52,305 nt. (total: 52,305 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
melanin: melC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

MQC87_RS01045: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

MQC87_RS01090: lysine/ornithine N-monooxygenase

smcogs: SMCOG1080: lysine/ornithine N-monooxygenase

Transferases: halogenase

MQC87_RS01075: halogenase

smcogs: SMCOG1119: halogenase

Hydrolases: deformylase

MQC87_RS01030: peptide deformylase

smcogs: SMCOG1275: peptide deformylase

Ligases: ligase

MQC87_RS01050: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

MQC87_RS01055: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

MQC87_RS01070: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000909.3	0.59	other (other)	melanin	Streptomyces avermitilis
BGC0000912.3	0.55	other (other)	melanin	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000910.3	0.53	other (other)	melanin	Streptomyces coelicolor A3(2)
BGC0000911.3	0.52	other (other)	melanin	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000908.3	0.48	other (other)	melanin	Streptomyces avermitilis
BGC0001132.4	0.40	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.40	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001833.4	0.40	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	0.39	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001128.4	0.39	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001132.4	0.72	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.72	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001833.4	0.72	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	0.71	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001128.4	0.71	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.71	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.70	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001261.3	0.70	NRPS	AM-toxin	Alternaria alternata
BGC0001135.5	0.69	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001166.5	0.68	NRPS	HC-toxin	Alternaria jesenskae

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.46 out of 23.05

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.21 out of 28.19

Confidence: medium

Additional weak hits (16):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 19.22 out of 31.73

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.23 out of 32.74

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.79 out of 29.38

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.64 out of 21.84

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.01 out of 30.25

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.25 out of 30.25

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 18.28 out of 29.25

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 19.59 out of 33.73

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.58 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.64 out of 28.14

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.67 out of 26.33

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.41 out of 36.53

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 21.21 out of 32.74

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 19.57 out of 35.63

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.15 out of 18.57

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.41 out of 28.14

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 52305:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ser - D-X - X - X)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

MQC87_RS01055: X

AMP-binding (25..419): X

nrpys: Piz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: MWQAFDVSFQEGFVNTAGEVNHYGQSESAMVTSH
Nearest Stachelhaus code(s):: Piz DVQFNAHMVK (88% 8Å match)
Stachelhaus code match:: 100% (strong)

MQC87_RS01070: Ser - X - X - X

Search NORINE for peptide: strict or relaxed

AMP-binding (472..878): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LSTHFDVSVWEGSQVFAGEINMYGTTETTVHASF
Nearest Stachelhaus code(s):: Ser DVWSVAMVHK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1542..1940): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LTHHFDFAVWEGTQLVGGEINAYGPTECTVYASM
Nearest Stachelhaus code(s):: Phe DFWTVAAVCK (71% 8Å match); Val DFESLAAVYK (50% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (3049..3437): X

nrpys: Ile, Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LLSHFDVSVWEGTQFVGGEINAYGPTEGTVYASM
Nearest Stachelhaus code(s):: Leu or Ile DVWTIGAVDK (62% 8Å match)
Stachelhaus code match:: 80% (moderate)

AMP-binding (4101..4488): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: MSSHFDVSVWEGNQFVGGEINGYGETETFYASMS
Nearest Stachelhaus code(s):: dmeaTrp or 1Me-Trp DVWTHGGVAK (50% 8Å match); dmeaTrp DVWTHGGVAK (47% 8Å match)
Stachelhaus code match:: 70% (weak)

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
ZuR variant 1	Zinc-responsive repressor

NZ_JALDPQ010000035.1 - Region 2 - terpene

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Location: 69,927 - 93,881 nt. (total: 23,955 nt) Show pHMM detection rules used

Region on contig edge.

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

MQC87_RS01275: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

Transferases: methyltransferase

MQC87_RS01295: methyltransferase

smcogs: SMCOG1089: methyltransferase

Hydrolases: hydrolase

MQC87_RS01250: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

Ligases: synthetase

MQC87_RS01270: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000664.5	0.88	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000649.3	0.79	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001456.3	0.75	terpene	isorenieratene	Streptomyces argillaceus
BGC0000633.3	0.71	terpene	carotenoid	Streptomyces avermitilis
BGC0001227.3	0.71	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000648.3	0.53	terpene	carotenoid	Myxococcus xanthus
BGC0000645.3	0.53	terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0000646.5	0.51	terpene	β-carotein	uncultured bacterium
BGC0000640.3	0.50	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0000639.3	0.49	terpene	carotenoid	Enterobacteriaceae bacterium DC260

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000664.5	0.88	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000649.3	0.79	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001456.3	0.75	terpene	isorenieratene	Streptomyces argillaceus
BGC0000633.3	0.71	terpene	carotenoid	Streptomyces avermitilis
BGC0001227.3	0.71	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000648.3	0.53	terpene	carotenoid	Myxococcus xanthus
BGC0000645.3	0.53	terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0000646.5	0.51	terpene	β-carotein	uncultured bacterium
BGC0000640.3	0.50	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0000639.3	0.49	terpene	carotenoid	Enterobacteriaceae bacterium DC260

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
tetraterpene	C40 carotenoid		C40	unknown	unknown

Genes with terpene domains:

MQC87_RS01270: PT_FPPS_like

Domain 1 (53 - 363): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

MQC87_RS01280: PT_phytoene_like

Domain 1 (16 - 326): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → PSPP; FPP → squalene; FPP → diapophytoene; GGPP → phytoene; PSPP → hydroxysqualene

MQC87_RS01300: Lycopene_cycl

Domain 1 (6 - 385): Lycopene cyclase

Reactions:: C40_carotenoid → C40_carotenoid

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 19.35 out of 20.47

Confidence: strong

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 24.59 out of 29.72

Confidence: medium

Additional weak hits (6):

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.99 out of 26.85

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.06 out of 26.06

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 15.26 out of 28.14

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.43 out of 27.78

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.87 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.87 out of 26.06

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description
NtrC	Nitrogen regulatory protein C
VqsM	Regulator of quorum-sensing signalling systems

NZ_JALDPQ010000036.1 - Region 1 - NRPS,T1PKS

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Location: 180,210 - 243,020 nt. (total: 62,811 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidase oxidoreductase oxygenase

MQC87_RS02315: lysine/ornithine N-monooxygenase

smcogs: SMCOG1080: lysine/ornithine N-monooxygenase

MQC87_RS02330: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

MQC87_RS02375: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

MQC87_RS02380: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

MQC87_RS02390: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Transferases: acyltransferase aminotransferase glycosyltransferase transferase

MQC87_RS02320: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

MQC87_RS02340: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

MQC87_RS02350: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

MQC87_RS02355: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

MQC87_RS02365: polyketide synthase associated protein papA3

smcogs: SMCOG1209: polyketide synthase associated protein papA3

MQC87_RS02395: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

Hydrolases: esterase

MQC87_RS02285: thioesterase

smcogs: SMCOG1004: thioesterase

MQC87_RS02400: thioesterase

smcogs: SMCOG1004: thioesterase

Lyases: dehydratase

MQC87_RS02325: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

MQC87_RS02345: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: ligase synthase

MQC87_RS02385: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

MQC87_RS02405: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001132.4	0.76	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.74	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.74	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0002135.2	0.74	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001128.4	0.74	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.72	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002075.3	0.72	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0002286.3	0.72	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000342.4	0.71	NRPS	enniatin	Fusarium equiseti
BGC0001135.5	0.71	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002075.3	0.73	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001132.4	0.73	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.72	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.72	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.72	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2	0.71	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002286.3	0.71	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.70	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001261.3	0.69	NRPS	AM-toxin	Alternaria alternata
BGC0001135.5	0.69	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis

Similar known clusters from MIBiG 4.0

Similar subclusters

Transcription Factor Binding Sites

Binding sites found:

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.76 out of 23.05

Confidence: medium

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.82 out of 18.46

Confidence: medium

Additional weak hits (11):

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.97 out of 39.62

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.20 out of 26.85

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.72 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.55 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.80 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.06 out of 29.38

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.08 out of 27.78

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.59 out of 22.40

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.86 out of 26.85

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.71 out of 26.06

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.52 out of 28.19

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 180209 - 243020:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ccmal) + (redmal) + (Tyr - NMe-Phe) + (D-Leu - Leu - D-X - X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 212892 - 243020:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ccmal) + (redmal) + (Tyr - NMe-Phe) + (D-Leu - Leu - D-X - X)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

MQC87_RS02365: Leu - Leu - X - X

Search NORINE for peptide: strict or relaxed

AMP-binding (468..857): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: GRLTFDVSVFETSTVFAGEVNAYGQTESFYATVF
Nearest Stachelhaus code(s):: Leu DVFSVAAYAK (88% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2021..2411): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: GRLTFDVSVFETSTVFAGEVNAYGQTESFYATTY
Nearest Stachelhaus code(s):: Leu DVFSVAAYAK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3084..3478): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Unpolar aromatic ring (Phe, Trp)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LTTAFDAAFWEQMLTVGGEVNAYGPTETTVCGAI
Nearest Stachelhaus code(s):: Leu DAWMVGAVCK (65% 8Å match)
Stachelhaus code match:: 90% (moderate)

AMP-binding (4626..5027): X

nrpys: Phe, Trp, Ph-Gly, Tyr, bOH-Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LDRNFDTSTYEVAMWTVGDVNGYGPTETTAATSM
Nearest Stachelhaus code(s):: Abu DTYWWGGTFK (68% 8Å match)
Stachelhaus code match:: 60% (weak)

MQC87_RS02385: Tyr - Phe

Search NORINE for peptide: strict or relaxed

AMP-binding (465..864): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: LAQAFDAAVSEMTLIVAGEINAYGPTEATVCATM
Nearest Stachelhaus code(s):: Tyr DASTIAAVCK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1524..1923): Phe

nrpys: Phe

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Unpolar aromatic ring (Phe, Trp)
Single AA prediction:: phe (Phe)

Stachelhaus prediction details:

Stachelhaus sequence:: VLQAFDSAVWEFTLIVAGEINGYGPTEATVSATM
Nearest Stachelhaus code(s):: His DTWTIASVSK (74% 8Å match); Phe DAWTIAGVCK (56% 8Å match)
Stachelhaus code match:: 80% (moderate)

MQC87_RS02405: mal

PKS_AT (574..873): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 163.4
inactive: 89.8
Methoxymalonyl-CoA: 62.6
Methylmalonyl-CoA: 57.8
Propionyl-CoA: 30.4
Ethylmalonyl-CoA: 24.9
Benzoyl-CoA: 23.7
CHC-CoA: 21.0
Isobutyryl-CoA: 19.3
Acetyl-CoA: 15.8
trans-1,2-CPDA: 15.2
2-Methylbutyryl-CoA: 14.2
fatty_acid: 12.4
3-Methylbutyryl-CoA: 0.0

MQC87_RS02410: mal

PKS_AT (0..215): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 154.9
inactive: 79.0
Methoxymalonyl-CoA: 64.4
Methylmalonyl-CoA: 54.7
Isobutyryl-CoA: 23.1
Ethylmalonyl-CoA: 21.9
Propionyl-CoA: 21.3
2-Methylbutyryl-CoA: 20.8
Acetyl-CoA: 13.4
Benzoyl-CoA: 12.1
trans-1,2-CPDA: 11.3
fatty_acid: 10.5
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
RpoN	Regulator of nitrogen assimilation and virulence

NZ_JALDPQ010000040.1 - Region 1 - lassopeptide

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Location: 82,118 - 104,653 nt. (total: 22,536 nt) Show pHMM detection rules used

lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lasso peptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: acetyltransferase

MQC87_RS03685: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

Hydrolases: hydrolase

MQC87_RS03695: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002006.2	0.78	ribosomal	albusnodin	Streptomyces albus
BGC0001552.3	0.44	ribosomal	citrulassin F	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0002298.2	0.44	ribosomal	lassomycin-like peptide	Sanguibacter keddieii DSM 10542
BGC0001548.4	0.43	ribosomal	citrulassin A	Streptomyces albulus
BGC0001549.3	0.43	ribosomal	citrulassin B	Streptomyces aurantiacus JA 4570
BGC0002053.3	0.43	ribosomal	ulleungdin	Streptomyces sp.
BGC0001634.3	0.43	ribosomal	keywimysin	Streptomyces sp. NRRL F-5702
BGC0001550.3	0.43	ribosomal	citrulassin D	Streptomyces katrae
BGC0000575.5	0.43	ribosomal	lariatin	Rhodococcus jostii
BGC0001493.5	0.42	ribosomal	achromosin	Streptomyces achromogenes subsp. achromogenes

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002006.2	0.78	ribosomal	albusnodin	Streptomyces albus
BGC0001552.3	0.44	ribosomal	citrulassin F	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0002298.2	0.44	ribosomal	lassomycin-like peptide	Sanguibacter keddieii DSM 10542
BGC0001548.4	0.43	ribosomal	citrulassin A	Streptomyces albulus
BGC0001549.3	0.43	ribosomal	citrulassin B	Streptomyces aurantiacus JA 4570
BGC0002053.3	0.43	ribosomal	ulleungdin	Streptomyces sp.
BGC0001634.3	0.43	ribosomal	keywimysin	Streptomyces sp. NRRL F-5702
BGC0001550.3	0.43	ribosomal	citrulassin D	Streptomyces katrae
BGC0000575.5	0.43	ribosomal	lariatin	Rhodococcus jostii
BGC0001493.5	0.42	ribosomal	achromosin	Streptomyces achromogenes subsp. achromogenes

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lasso peptide predictions

Lassopeptides - No core peptides found.

Transcription Factor Binding Sites

Binding sites found:

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.46 out of 23.05

Confidence: medium

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 27.35 out of 32.38

Confidence: medium

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.27 out of 26.85

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05

Confidence: medium

Additional weak hits (3):

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.78 out of 20.01

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 19.64 out of 36.54

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 24.15 out of 32.93

Confidence: weak

Lasso peptides

TFBS Finder

Core peptide predictions

No core peptides found.

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
CsoR	Copper-responsive repressor
RutR	Regulator of the pyrimidine and purine metabolism

NZ_JALDPQ010000041.1 - Region 1 - lanthipeptide-class-iv

Download region SVG

Location: 51,078 - 73,948 nt. (total: 22,871 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-iv: (cds(LANC_like and Pkinase) and not micKC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000551.5	0.61	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000501.3	0.59	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000496.5	0.59	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000563.4	0.58	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0002337.2	0.57	ribosomal	class IV lanthipeptide, SflA	Streptomyces sp. NRRL S-1022
BGC0000519.4	0.56	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0001226.4	0.53	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0002698.2	0.51	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000513.3	0.47	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000518.3	0.45	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000551.5	0.61	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000501.3	0.59	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000496.5	0.59	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000563.4	0.58	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0002337.2	0.57	ribosomal	class IV lanthipeptide, SflA	Streptomyces sp. NRRL S-1022
BGC0000519.4	0.56	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0001226.4	0.53	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0002698.2	0.51	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000513.3	0.47	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000518.3	0.45	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for MQC87_RS04420

MQC87_RS04410

Leader:

MIDNTMTVDVDELQTLEGEESVALAG

Core:

CTRTCTWTCSITSIEQQ

Core with dehydrations:

CysDhbRDhbCysDhbWDhbCysDhaIDhbDhaIEQQ

antiSMASH-DB 4.0 matches for MQC87_RS04410

100.0%

NZ_BMRY01000001.1and 16 others:

NZ_BNBJ01000011.1 Lanthipeptides: IE304_RS20740_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS36570_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS35105_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS21260_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS33035_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS20475_lanthipeptideNZ_JALDPQ010000041.1 Lanthipeptides: MQC87_RS04410_lanthipeptideNZ_JAMFLF010000024.1 Lanthipeptides: M1212_RS34580_lanthipeptideNZ_KL573566.1 Lanthipeptides: BG84_RS1000000140120_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS35670_lanthipeptideNZ_KZ819182.1 Lanthipeptides: DBP21_RS35710_lanthipeptideNZ_LIVT01000009.1 Lanthipeptides: AMK24_RS34305_lanthipeptideNZ_LIXK01000001.1 Lanthipeptides: AMK23_RS37735_lanthipeptideNZ_ML123117.1 Lanthipeptides: EES46_RS36000_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS33060_lanthipeptideNZ_WWGD01000043.1 Lanthipeptides: GTY72_RS37555_lanthipeptide

Lanthipeptides: IE140_RS05545_lanthipeptide

1

CTRTCTWTCSITSIEQQ

17

CTRTCTWTCSITSIEQQ

1

CTRTCTWTCSITSIEQQ

17

94.1%

NZ_JNLT01000004.1:

Lanthipeptides: CD02_RS38845_lanthipeptide

1

CTRTCTWTCSITSIEQQ

17

CT+TCTWTCSITSIEQQ

1

CTKTCTWTCSITSIEQQ

17

82.4%

NZ_LZRD01000027.1:

Lanthipeptides: A3Q37_RS37510_lanthipeptide

1

CTRTCTWTCSITSIEQQ

17

CT+TCTWTC ITS+EQQ

1

CTKTCTWTCRITSLEQQ

17

with 8 more sequence matches

82.4%

NZ_ML123034.1:

Lanthipeptides: EES43_RS30965_lanthipeptide

1

CTRTCTWTCSITSIEQQ

17

CT TC WTC+ITSIEQQ

1

CTATCAWTCAITSIEQQ

17

72.2%

NZ_PGGV01000018.1:

Lanthipeptides: CUT39_RS20215_lanthipeptide

1

CTRTCTWTCSITSIEQ

16

CT TCTWTCSITS +Q

3

CTWTCTWTCSITSFQQ

18

40.9%

NZ_CP017708.2and 1 other:

NZ_CP017708.2 Lanthipeptides: BJP36_RS08575_lanthipeptide

Lanthipeptides: BJP36_RS08575_lanthipeptide

1

CTRTCTWTCSITSIEQQ

17

C TC +TC +T I+QQ

1

CGHTCGYTCGVTEIKQQ

17

38.9%

NZ_CP017599.1and 1 other:

NZ_CP017599.1 Lanthipeptides: BJP34_RS13165_lanthipeptide

Lanthipeptides: BJP34_RS13165_lanthipeptide

4

TCTWTCSITSIEQQ

17

+CT +C IT I Q

3

SCTVSCLITIINNQ

16

33.3%

NC_017803.1:

Lanthipeptides: ACPL_RS45060_lanthipeptide

1

CTRTCTWTCSITS

13

C TC TCS+T

8

CKGTCPATCSVTG

20

33.3%

NZ_BROP01000004.1:

Lanthipeptides: OPC11_RS12060_lanthipeptide

1

CTRTCTWTCSIT

12

C TCT +C++T

4

CLLTCTVSCAVT

15

25.0%

NZ_VATK01000028.1:

Lanthipeptides: FDO66_RS19480_lanthipeptide

3

RTCTWTCSIT

12

R C W CS T

1

RPCGWICSYT

10

9.8%

NZ_CP040414.1:

Lanthipeptides: FE331_RS05905_lanthipeptide

1

CTRTCTWTC

9

C R+C W C

38

CNRSCGWGC

46

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.39 out of 19.26

Confidence: strong

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.07 out of 20.47

Confidence: medium

Additional weak hits (5):

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 21.87 out of 36.53

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.70 out of 27.04

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.18 out of 26.85

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.40 out of 21.84

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.18 out of 28.19

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

MQC87_RS04410 - Class III

Cleavage pHMM score: 2.70

RODEO score: 0

Monoisotopic mass: 1833.8 Da

Molecular weight: 1835.1 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 1853.1 Da N = 1; 1871.1 Da N = 2; 1889.1 Da N = 3; 1907.1 Da N = 4

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
VqsM	Regulator of quorum-sensing signalling systems

NZ_JALDPQ010000042.1 - Region 1 - NRPS,T1PKS,lassopeptide

Download region SVG

Location: 31,497 - 90,009 nt. (total: 58,513 nt) Show pHMM detection rules used

Region on contig edge.

lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lasso peptides

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

MQC87_RS04680: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

MQC87_RS04890: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

MQC87_RS04900: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Transferases: acylase aminotransferase

MQC87_RS04895: aminotransferase

smcogs: SMCOG1019: aminotransferase

MQC87_RS04905: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: hydrolase

MQC87_RS04735: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Ligases: ligase

MQC87_RS04885: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001634.3	0.67	ribosomal	keywimysin	Streptomyces sp. NRRL F-5702
BGC0001825.4	0.61	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001240.4	0.61	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0000357.5	0.57	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001275.3	0.53	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001257.3	0.53	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001485.4	0.45	other (other)	chuangxinmycin	Actinoplanes tsinanensis
BGC0001548.4	0.40	ribosomal	citrulassin A	Streptomyces albulus
BGC0002825.2	0.39	ribosomal	nocapeptin A	Nocardia terpenica IFM 0406
BGC0002171.2	0.39	NRPS, PKS	pyrophen, campyrone B	Aspergillus niger ATCC 1015

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001634.3	0.88	ribosomal	keywimysin	Streptomyces sp. NRRL F-5702
BGC0001548.4	0.72	ribosomal	citrulassin A	Streptomyces albulus
BGC0001507.3	0.67	ribosomal	anantin C	Streptomyces olindensis
BGC0001825.4	0.64	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001240.4	0.64	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001550.3	0.63	ribosomal	citrulassin D	Streptomyces katrae
BGC0000357.5	0.62	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0000578.3	0.62	ribosomal	SRO15-2005	Streptomyces filamentosus NRRL 15998
BGC0001645.3	0.61	ribosomal	lagmysin	Streptomyces sp. NRRL S-118
BGC0001551.4	0.61	ribosomal	citrulassin E	Streptomyces glaucescens

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lasso peptide predictions

Lassopeptide(s) for MQC87_RS04740

MQC87_RS04740

Leader:

MKQQKKAYVKPSLFKQGDFSKKTA

Full core:

GYFYGSYKEYWVRRII

Putative macrolactam:

GYFYGSYKE

antiSMASH-DB 4.0 matches for MQC87_RS04740

100.0%

NZ_AQRK01000073.1and 34 others:

NZ_ARPF01000020.1 Lassopeptides: B083_RS1000000135975_lassopeptideNZ_BMSP01000033.1 Lassopeptides: IE150_RS31095_lassopeptideNZ_BNBJ01000018.1 Lassopeptides: IE304_RS27885_lassopeptideNZ_CP011522.1 Lassopeptides: ABE83_RS36070_lassopeptideNZ_CP015362.1 Lassopeptides: A6E92_RS32825_lassopeptideNZ_CP020570.1 Lassopeptides: B1H20_RS34515_lassopeptideNZ_CP024957.1 Lassopeptides: CVT27_RS18750_lassopeptideNZ_CP030930.1 Lassopeptides: DTW94_RS18860_lassopeptideNZ_CP032543.1 Lassopeptides: D6270_RS18940_lassopeptideNZ_CP058556.1 Lassopeptides: HXS80_RS15025_lassopeptideNZ_CP059898.1 Lassopeptides: H3V39_RS14565_lassopeptideNZ_CP070242.1 Lassopeptides: I6J39_RS14950_lassopeptideNZ_CP070260.1 Lassopeptides: I6J40_RS19545_lassopeptideNZ_CP077652.1 Lassopeptides: KRR37_RS18710_lassopeptideNZ_CP079114.1 Lassopeptides: KV381_RS20695_lassopeptideNZ_CP101140.1 Lassopeptides: NF554_RS14180_lassopeptideNZ_CP101397.1 Lassopeptides: NLU04_RS02420_lassopeptideNZ_CP113262.1 Lassopeptides: OUQ49_RS18920_lassopeptideNZ_JAGGOV010000040.1 Lassopeptides: J7E92_RS24040_lassopeptideNZ_JAHHWT010000002.1 Lassopeptides: KM153_RS04955_lassopeptideNZ_JAJDST010000050.1 Lassopeptides: LJC81_RS32430_lassopeptideNZ_JALDPQ010000042.1 Lassopeptides: MQC87_RS04740_lassopeptideNZ_JAMFLF010000013.1 Lassopeptides: M1212_RS26530_lassopeptideNZ_JANRMN010000006.1 Lassopeptides: NW249_RS11850_lassopeptideNZ_KB890924.1 Lassopeptides: B053_RS1000000136555_lassopeptideNZ_KB891296.1 Lassopeptides: B061_RS39115_lassopeptideNZ_KL573564.1 Lassopeptides: BG84_RS1000000139430_lassopeptideNZ_KZ819159.1 Lassopeptides: DBP19_RS18270_lassopeptideNZ_LR881952.1 Lassopeptides: STRPST75_RS15280_lassopeptideNZ_LZQS01000001.1 Lassopeptides: STIB_RS37415_lassopeptideNZ_RCOL01000001.1 Lassopeptides: STAN_RS20170_lassopeptideNZ_VEHK01000003.1 Lassopeptides: FS984_RS09665_lassopeptideNZ_WUEJ01000001.1 Lassopeptides: GRQ63_RS00790_lassopeptideNZ_WWGL01000031.1 Lassopeptides: GTY38_RS20560_lassopeptide

Lassopeptides: YUW_RS35360_lassopeptide

1

GYFYGSYKEYWVRRII

16

GYFYGSYKEYWVRRII

1

GYFYGSYKEYWVRRII

16

93.8%

NZ_CP110539.1and 1 other:

NZ_CP112880.1 Lassopeptides: N7925_RS15605_lassopeptide

Lassopeptides: OH133_RS17115_lassopeptide

1

GYFYGSYKEYWVRRI

15

GYFYGSYKEYWVRRI

1

GYFYGSYKEYWVRRI

15

87.5%

NZ_BMRY01000001.1and 14 others:

NZ_BMSZ01000030.1 Lassopeptides: IE135_RS32485_lassopeptideNZ_CP010833.1 Lassopeptides: TK78_RS35300_lassopeptideNZ_CP021707.1 Lassopeptides: CCZ36_RS19605_lassopeptideNZ_CP084357.1 Lassopeptides: LEL86_RS33655_lassopeptideNZ_DS999644.1 Lassopeptides: SSGG_RS36910_lassopeptideNZ_JNLT01000024.1 Lassopeptides: CD02_RS38355_lassopeptideNZ_KZ679082.1 Lassopeptides: C6W96_RS19995_lassopeptideNZ_KZ819154.1 Lassopeptides: DBP12_RS14735_lassopeptideNZ_KZ819178.1 Lassopeptides: DBP20_RS19850_lassopeptideNZ_KZ819182.1 Lassopeptides: DBP21_RS20195_lassopeptideNZ_LACR01000007.1 Lassopeptides: YW5_RS36195_lassopeptideNZ_LZRD01000023.1 Lassopeptides: A3Q37_RS36590_lassopeptideNZ_NNBN01000001.1 Lassopeptides: CG717_RS32755_lassopeptideNZ_WWGD01000017.1 Lassopeptides: GTY72_RS09250_lassopeptide

Lassopeptides: IE140_RS06105_lassopeptide

1

GYFYGSYKEYWVRRII

16

GYF GSYKEYW RRII

1

GYFVGSYKEYWSRRII

16

with 12 more sequence matches

Only the first 10 are displayed here.

87.5%

NZ_CP013738.1and 4 others:

NZ_CP029361.1 Lassopeptides: DIJ69_RS14415_lassopeptideNZ_CP090837.1 Lassopeptides: LZ559_RS19885_lassopeptideNZ_JAJUKK010000001.1 Lassopeptides: LXH09_RS00260_lassopeptideNZ_LIXK01000001.1 Lassopeptides: AMK23_RS36895_lassopeptide

Lassopeptides: WQO_RS35795_lassopeptide

1

GYFYGSYKEYWVRRII

16

GYF GSYKEYW RRII

1

GYFVGSYKEYWTRRII

16

82.4%

NC_021177.1and 5 others:

NZ_BMUG01000007.1 Lassopeptides: IE264_RS21365_lassopeptideNZ_CP054926.1 Lassopeptides: HUT09_RS19455_lassopeptideNZ_CP068598.1 Lassopeptides: IFE09_RS19740_lassopeptideNZ_CP071044.1 Lassopeptides: JHY03_RS19320_lassopeptideNZ_JOJC01000016.1 Lassopeptides: IO23_RS1000000136610_lassopeptide

Lassopeptides: SFUL_RS36235_lassopeptide

1

GYFYGSYKEYWVRRII

16

GYF GSYKEYWVRRI+

1

GYFVGSYKEYWVRRIV

16

81.2%

NZ_BDHJ01000011.1and 4 others:

NZ_BMTW01000001.1 Lassopeptides: IE134_RS04135_lassopeptideNZ_CP076457.1 Lassopeptides: KME66_RS14195_lassopeptideNZ_KZ268499.1 Lassopeptides: CE422_RS34520_lassopeptideNZ_ML123117.1 Lassopeptides: EES46_RS05210_lassopeptide

Lassopeptides: BHQ08_RS34645_lassopeptide

1

GYFYGSYKEYWVRRII

16

GYF GSYKEYW RRI+

1

GYFVGSYKEYWTRRIV

16

81.2%

NZ_CP020563.1:

Lassopeptides: B7C62_RS35255_lassopeptide

1

GYFYGSYKEYWVRRII

16

GYF GSYKE+W RRII

1

GYFIGSYKEFWSRRII

16

75.0%

NZ_KB891808.1:

Lassopeptides: B072_RS47760_lassopeptide

1

GYFYGSYKEYWVRRII

16

GYF GSYKE+ VRRI+

1

GYFVGSYKEWIVRRIV

16

75.0%

NZ_PGGW01000069.1:

Lassopeptides: CUT44_RS32610_lassopeptide

1

GYFYGSYKEYWVRRII

16

GYFYGSYKE+ RRI+

1

GYFYGSYKEFLSRRIV

16

68.8%

NZ_CP061281.1:

Lassopeptides: IAG42_RS10065_lassopeptide

1

GYFYGSYKEYWVRRII

16

GYF G YKE+ VRRI+

1

GYFVGPYKEWIVRRIV

16

62.5%

NZ_FOET01000001.1:

Lassopeptides: BMY40_RS27365_lassopeptide

1

GYFYGSYKEYWVRRII

16

GYF G YKEY+ RR +

1

GYFVGKYKEYFSRRFV

16

62.5%

NZ_FOSG01000008.1and 1 other:

NZ_PDKQ02000012.1 Lassopeptides: BFM75_RS03245_lassopeptide

Lassopeptides: BM237_RS28735_lassopeptide

1

GYFYGSYKEYWVRRII

16

GYF+G YKEY+ RR +

1

GYFFGKYKEYFSRRFV

16

58.8%

NZ_JACHEM010000013.1:

Lassopeptides: HNQ79_RS23595_lassopeptide

1

GYFYGSYKEYWVRRII

16

G FY S KEYW RR+

1

GMFYASCKEYWSRRLC

16

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.39 out of 19.26

Confidence: strong

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 22.05 out of 22.40

Confidence: strong

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.13 out of 19.26

Confidence: medium

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 23.00 out of 27.04

Confidence: medium

Additional weak hits (20):

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.17 out of 26.85

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.98 out of 28.14

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.09 out of 30.25

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.11 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.70 out of 29.38

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.60 out of 30.22

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.59 out of 39.62

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.51 out of 27.78

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 18.16 out of 31.73

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 16.65 out of 31.73

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.34 out of 30.22

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.60 out of 21.84

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.52 out of 20.97

Confidence: weak

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.03 out of 19.26

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.93 out of 28.19

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 18.90 out of 35.63

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 23.25 out of 36.53

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.56 out of 24.78

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.33 out of 32.93

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.77 out of 28.19

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

Lasso peptides

NRPS/PKS products

NRPS/PKS substrates

RREFinder

TFBS Finder

Core peptide predictions

MQC87_RS04740 - Class II: Cleavage pHMM score: 0.20; RODEO score: 20; Monoisotopic mass: 2081.0 Da; Molecular weight: 2082.4 Da; Number of bridges: 0

Predicted core structure(s)

For candidate cluster 1, location 31496 - 90009:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-X - Val) + (emal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 54097 - 90009:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-X - Val) + (emal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 66887 - 90009:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-X - Val) + (emal)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

MQC87_RS04885: X - Val

Search NORINE for peptide: strict or relaxed

AMP-binding (26..428): X

nrpys: Gly, Ala, Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LEAAFDMSVWDATLVIGGEINAYGPTESTVWATF
Nearest Stachelhaus code(s):: Phe DAWTVAAVCK (71% 8Å match)
Stachelhaus code match:: 70% (weak)

AMP-binding (1851..2257): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LSTHFDFSVWEGNQVFGGEVNMYGITETTVHVTF
Nearest Stachelhaus code(s):: Val DFWNVGMVHK (97% 8Å match); Thr DFWNVGMVHK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

MQC87_RS04905: emal

PKS_AT (330..626): emal

ATSignature: Isobutyryl-CoA, Methylmalonyl-CoA, Ethylmalonyl-CoA

Top 3 matches:: Isobutyryl-CoA: 79.2%; Methylmalonyl-CoA: 79.2%; Ethylmalonyl-CoA: 79.2%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 170.4
Methylmalonyl-CoA: 169.9
2-Methylbutyryl-CoA: 154.2
Methoxymalonyl-CoA: 138.2
Propionyl-CoA: 115.1
trans-1,2-CPDA: 111.7
CHC-CoA: 86.8
Malonyl-CoA: 73.7
Benzoyl-CoA: 50.0
Isobutyryl-CoA: 47.3
3-Methylbutyryl-CoA: 27.9
fatty_acid: 15.0
Acetyl-CoA: 13.3
inactive: 10.5

RRE predictions

: RRE type: Stand_Alone_Lasso_RRE; Location: 0 - 82; Score: 83.4

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
CRP	Cyclic AMP receptor protein
DasR	N-acetylglucosamine dependent repressor
HypR	L-hydroxyproline utilization repressor

NZ_JALDPQ010000045.1 - Region 1 - terpene

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Location: 69,380 - 90,456 nt. (total: 21,077 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

MQC87_RS06060: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

Transferases: formyltransferase

MQC87_RS06030: methionyl-tRNA formyltransferase

smcogs: SMCOG1228: methionyl-tRNA formyltransferase

Lyases: cyclase hydratase

MQC87_RS06050: Terpene synthase/cyclase metal-binding domain protein

smcogs: SMCOG1052: Terpene synthase/cyclase metal-binding domain protein

MQC87_RS06070: Nitrilase/cyanide hydratase and apolipoprotein

smcogs: SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002708.2	0.75	terpene	(+)-δ-cadinol	Coniophora puteana RWD-64-598 SS2
BGC0002707.2	0.47	terpene	(+)-δ-cadinol	Coniophora puteana RWD-64-598 SS2
BGC0000631.5	0.37	terpene	Botrydial, 8,9-epibotrydial, 1-epibotrydial, Dihydrobotrydial, 10-Oxo-dihydrobotrydial, 10-dehydroxy dihydrobotrydialone, 10-epi-dihydrobotrydial, Botryendial, Botryenalol, Botrydienal, Norbotrydialone acetate, 10-Oxodihydrobotry-1(9),4(5)-diendial, 10-Oxodehydrodihydrobotrydial, Dehydrobotrydienol, 11-Hydroxydehydrobotrydienol, 12-hydroxydehydrobotrydienol, Secobotrytriendiol, Secobotrytriene-10,12,15-triol, Secobotrydiene-3,10,15-triol, Secobotrydiene-3,4,10,15-tetraol, 4β-Acetoxytetrahydrobotryslactone	Botrytis cinerea B05.10
BGC0002034.3	0.36	other (other)	perquinoline A, perquinoline B, perquinoline C	Streptomyces sp. IB2014 016-6
BGC0000879.5	0.35	other (other)	toyocamycin, sangivamycin	Streptomyces rimosus
BGC0001677.3	0.35	PKS	mycophenolic acid	Penicillium roqueforti
BGC0002616.2	0.35	PKS	mycophenolic acid	Penicillium roqueforti
BGC0001360.3	0.34	PKS	mycophenolic acid	Penicillium roqueforti FM164
BGC0002619.2	0.34	PKS	mycophenolic acid	Penicillium brevicompactum
BGC0000881.3	0.33	other (other)	toyocamycin	Streptomyces ahygroscopicus subsp. wuzhouensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002708.2	0.75	terpene	(+)-δ-cadinol	Coniophora puteana RWD-64-598 SS2
BGC0002707.2	0.47	terpene	(+)-δ-cadinol	Coniophora puteana RWD-64-598 SS2
BGC0000631.5	0.37	terpene	Botrydial, 8,9-epibotrydial, 1-epibotrydial, Dihydrobotrydial, 10-Oxo-dihydrobotrydial, 10-dehydroxy dihydrobotrydialone, 10-epi-dihydrobotrydial, Botryendial, Botryenalol, Botrydienal, Norbotrydialone acetate, 10-Oxodihydrobotry-1(9),4(5)-diendial, 10-Oxodehydrodihydrobotrydial, Dehydrobotrydienol, 11-Hydroxydehydrobotrydienol, 12-hydroxydehydrobotrydienol, Secobotrytriendiol, Secobotrytriene-10,12,15-triol, Secobotrydiene-3,10,15-triol, Secobotrydiene-3,4,10,15-tetraol, 4β-Acetoxytetrahydrobotryslactone	Botrytis cinerea B05.10
BGC0002034.3	0.36	other (other)	perquinoline A, perquinoline B, perquinoline C	Streptomyces sp. IB2014 016-6
BGC0000879.5	0.35	other (other)	toyocamycin, sangivamycin	Streptomyces rimosus
BGC0001677.3	0.35	PKS	mycophenolic acid	Penicillium roqueforti
BGC0002616.2	0.35	PKS	mycophenolic acid	Penicillium roqueforti
BGC0001360.3	0.34	PKS	mycophenolic acid	Penicillium roqueforti FM164
BGC0002619.2	0.34	PKS	mycophenolic acid	Penicillium brevicompactum
BGC0000881.3	0.33	other (other)	toyocamycin	Streptomyces ahygroscopicus subsp. wuzhouensis

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
monoterpene			C10	C1-C10	none
sesquiterpene			C15	C1-C10	none

Genes with terpene domains:

MQC87_RS06050: T1TS

Domain 1 (4 - 315): Type 1 terpene synthase

Subtype: Germacrene A synthase type

Reactions:: GPP → monoterpene_C1-C10; FPP → sesquiterpene_C1-C10

Transcription Factor Binding Sites

Binding sites found:

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16

Confidence: strong

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.10 out of 23.79

Confidence: medium

Additional weak hits (24):

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 19.00 out of 27.55

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.66 out of 26.06

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.43 out of 39.62

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 16.37 out of 26.12

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.21 out of 26.33

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.70 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.15 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.18 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 16.76 out of 26.06

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.15 out of 18.57

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.23 out of 20.97

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.14 out of 26.06

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 15.93 out of 31.73

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.08 out of 26.06

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 16.62 out of 31.73

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.01 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 18.48 out of 28.14

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.92 out of 26.33

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.67 out of 26.33

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.84 out of 26.33

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.72 out of 28.19

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.24 out of 28.19

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.90 out of 28.19

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.45 out of 28.19

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate
GPP	Geranyl diphoshate

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
IolR	Regulator of the inositol catabolism

NZ_JALDPQ010000047.1 - Region 1 - NRPS,T1PKS

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Location: 1,476 - 50,853 nt. (total: 49,378 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

MQC87_RS07435: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

MQC87_RS07440: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

MQC87_RS07445: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

MQC87_RS07450: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

MQC87_RS07510: NADH:flavin oxidoreductase/NADH oxidase

smcogs: SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

MQC87_RS07535: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: aminotransferase

MQC87_RS07465: aminotransferase class V

smcogs: SMCOG1139: aminotransferase class V

Hydrolases: hydrolase

MQC87_RS07430: alpha/beta hydrolase domain-containing protein

smcogs: SMCOG1066: alpha/beta hydrolase domain-containing protein

Isomerases: racemase

MQC87_RS07390: mandelate racemase/muconate lactonizing enzyme

smcogs: SMCOG1268: mandelate racemase/muconate lactonizing enzyme

Ligases: synthase

MQC87_RS07455: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Translocases: transport

MQC87_RS07495: MMPL domain-containing transport protein

smcogs: SMCOG1035: MMPL domain-containing transport protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001043.4	1.39	NRPS, PKS	SGR PTMs, SGR PTM Compound b, SGR PTM Compound c, SGR PTM Compound d	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002365.2	1.30	PKS, other (other)	10-epi-HSAF, 10-epi-3-deOH-HSAF, 10-epi-maltophilin, 10-epi-xanthobaccin C, 10-epi-hydroxymaltophilin, 10-epi-FI-2	Streptomyces sp.
BGC0001275.3	0.90	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.90	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.90	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0000996.5	0.89	NRPS, PKS	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0001726.4	0.75	NRPS, PKS	pactamide A, pactamide B, pactamide C, pactamide D, pactamide E, pactamide F	Streptomyces pactum
BGC0002509.3	0.72	NRPS	montamide A, capsimycin, clifednamide A, frontalamide A, combamide A	Streptomyces sp.
BGC0001132.4	0.68	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.68	NRPS	icosalide A, icosalide B	Burkholderia gladioli

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001043.4	0.89	NRPS, PKS	SGR PTMs, SGR PTM Compound b, SGR PTM Compound c, SGR PTM Compound d	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002365.2	0.86	PKS, other (other)	10-epi-HSAF, 10-epi-3-deOH-HSAF, 10-epi-maltophilin, 10-epi-xanthobaccin C, 10-epi-hydroxymaltophilin, 10-epi-FI-2	Streptomyces sp.
BGC0001275.3	0.75	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.75	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.75	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0000996.5	0.75	NRPS, PKS	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0001726.4	0.70	NRPS, PKS	pactamide A, pactamide B, pactamide C, pactamide D, pactamide E, pactamide F	Streptomyces pactum
BGC0002509.3	0.69	NRPS	montamide A, capsimycin, clifednamide A, frontalamide A, combamide A	Streptomyces sp.
BGC0001132.4	0.67	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.67	NRPS	icosalide A, icosalide B	Burkholderia gladioli

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.09 out of 20.47

Confidence: medium

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 24.84 out of 29.72

Confidence: medium

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 28.35 out of 35.63

Confidence: medium

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 23.25 out of 29.72

Confidence: medium

Additional weak hits (7):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.32 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.06 out of 29.38

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.92 out of 26.33

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 19.81 out of 30.98

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.29 out of 18.57

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 18.82 out of 25.88

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.01 out of 28.19

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 1475 - 50853:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk - Orn)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

MQC87_RS07455: pk - Orn

Search NORINE for peptide: strict or relaxed

PKS_AT (548..844): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 70.8%; Methylmalonyl-CoA: 58.3%; CE-Malonyl-CoA: 54.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 130.6
Methoxymalonyl-CoA: 121.6
Malonyl-CoA: 118.3
Ethylmalonyl-CoA: 108.2
Isobutyryl-CoA: 92.4
Acetyl-CoA: 75.1
Propionyl-CoA: 68.3
2-Methylbutyryl-CoA: 68.0
trans-1,2-CPDA: 67.8
Benzoyl-CoA: 59.8
CHC-CoA: 49.5
fatty_acid: 43.0
3-Methylbutyryl-CoA: 39.1
inactive: 34.0

AMP-binding (2298..2712): Orn

nrpys: Orn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: Orn and hydroxy-Orn specific (Orn, OH-Orn)
Single AA prediction:: orn (Orn)

Stachelhaus prediction details:

Stachelhaus sequence:: AAWAFDVFTGDREFVVGSDVNSYGLTEATIDSAY
Nearest Stachelhaus code(s):: Orn DVGEVGSIDK (85% 8Å match)
Stachelhaus code match:: 100% (strong)

TFBS definitions

Regulator	Description
NrtR	NAD synthesis repressor
NtrC	Nitrogen regulatory protein C
VqsM	Regulator of quorum-sensing signalling systems

NZ_JALDPQ010000047.1 - Region 2 - terpene

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Location: 106,088 - 132,651 nt. (total: 26,564 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

MQC87_RS07935: dehydrogenase

smcogs: SMCOG1181: dehydrogenase

Transferases: aminotransferase transferase

MQC87_RS07875: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

MQC87_RS07940: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

Lyases: dehydratase

MQC87_RS07950: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthetase

MQC87_RS07895: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000663.5	0.69	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0000647.3	0.57	terpene	carotenoid	Rhodobacter sphaeroides
BGC0000656.5	0.50	terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0002162.3	0.49	terpene	sesterfisherol, sesterfisheric acid, compound 6, compound 7a, compound 5, compound 8	Aspergillus fischeri NRRL 181
BGC0002610.3	0.49	terpene	stellatic acid	Aspergillus stellatus
BGC0000630.3	0.49	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000646.5	0.49	terpene	β-carotein	uncultured bacterium
BGC0002173.2	0.48	saccharide, terpene	fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol	Aspergillus fumigatus A1163
BGC0000640.3	0.48	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0002508.2	0.48	other (other)	8-azaguanine	Streptomyces pathocidini

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000663.5	0.69	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0000647.3	0.57	terpene	carotenoid	Rhodobacter sphaeroides
BGC0000656.5	0.50	terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0002162.3	0.49	terpene	sesterfisherol, sesterfisheric acid, compound 6, compound 7a, compound 5, compound 8	Aspergillus fischeri NRRL 181
BGC0002610.3	0.49	terpene	stellatic acid	Aspergillus stellatus
BGC0000630.3	0.49	terpene	(2R,3S,3'S)-2-hydroxyastaxanthin	Paracoccus haeundaensis
BGC0000646.5	0.49	terpene	β-carotein	uncultured bacterium
BGC0002173.2	0.48	saccharide, terpene	fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol	Aspergillus fumigatus A1163
BGC0000640.3	0.48	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0002508.2	0.48	other (other)	8-azaguanine	Streptomyces pathocidini

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	hopanoid		C30	hopanoid skeleton	unknown
triterpene	polypodane		C30	polypodane skeleton	unknown

Genes with terpene domains:

MQC87_RS07890: T2TS

Domain 1 (25 - 652): Type 2 terpene synthase

Subtype: Squalene substrate

Reactions:: squalene → hopanoid; squalene → polypodane

MQC87_RS07895: PT_FPPS_like

Domain 1 (74 - 366): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

MQC87_RS07905: PT_phytoene_like

Domain 1 (13 - 296): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → PSPP; FPP → squalene; FPP → diapophytoene; GGPP → phytoene; PSPP → hydroxysqualene

MQC87_RS07910: PT_phytoene_like

Domain 1 (16 - 284): Prenyltransferase; Phytoene synthase like

Subtype: Hydroxysqualene synthase

Reactions:: PSPP → hydroxysqualene

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.09 out of 23.79

Confidence: medium

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 19.02 out of 21.84

Confidence: medium

Additional weak hits (10):

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 20.52 out of 32.74

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.38 out of 26.85

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.37 out of 27.78

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.81 out of 27.78

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.92 out of 30.22

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.59 out of 29.38

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.23 out of 30.98

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.72 out of 28.19

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.04 out of 29.65

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 21.29 out of 36.53

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description
IolR	Regulator of the inositol catabolism
MexT	Global virulence regulator

NZ_JALDPQ010000049.1 - Region 1 - T1PKS

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Location: 1 - 4,284 nt. (total: 4,284 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

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other genes

resistance

TTA codons

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NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: acylase

MQC87_RS09300: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000122.5	0.49	PKS	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0000353.5	0.47	NRPS	tacrolimus	Streptomyces sp. MA6548
BGC0000041.3	0.47	PKS	oronofacic acid	Pseudomonas syringae
BGC0002138.2	0.46	PKS	fuelimycin A, fuelimicin B, fuelimicin C	Streptomyces albireticuli NRRL B-1670
BGC0001544.3	0.45	NRPS, PKS	chlorflavonin	Aspergillus campestris IBT 28561
BGC0001235.4	0.44	NRPS, PKS	antalid	Polyangium spumosum
BGC0000067.5	0.42	PKS	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000143.5	0.40	PKS	salinomycin	Streptomyces albus
BGC0001647.3	0.40	PKS	lagunapyrone A, lagunapyrone B, lagunapyrone C	Streptomyces sp. MP131-18
BGC0000999.4	0.40	NRPS, PKS	heat-stable antifungal factor	Lysobacter enzymogenes

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000122.5	0.49	PKS	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0000353.5	0.47	NRPS	tacrolimus	Streptomyces sp. MA6548
BGC0000041.3	0.47	PKS	oronofacic acid	Pseudomonas syringae
BGC0002138.2	0.46	PKS	fuelimycin A, fuelimicin B, fuelimicin C	Streptomyces albireticuli NRRL B-1670
BGC0001544.3	0.45	NRPS, PKS	chlorflavonin	Aspergillus campestris IBT 28561
BGC0001235.4	0.44	NRPS, PKS	antalid	Polyangium spumosum
BGC0000067.5	0.42	PKS	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000143.5	0.40	PKS	salinomycin	Streptomyces albus
BGC0001647.3	0.40	PKS	lagunapyrone A, lagunapyrone B, lagunapyrone C	Streptomyces sp. MP131-18
BGC0000999.4	0.40	NRPS, PKS	heat-stable antifungal factor	Lysobacter enzymogenes

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 4284:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ccmal)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

MQC87_RS09300: mal

PKS_AT (0..221): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 158.2
inactive: 84.8
Methoxymalonyl-CoA: 74.7
Methylmalonyl-CoA: 59.5
Isobutyryl-CoA: 26.3
Propionyl-CoA: 26.2
Ethylmalonyl-CoA: 24.5
2-Methylbutyryl-CoA: 24.4
Acetyl-CoA: 13.3
Benzoyl-CoA: 12.1
fatty_acid: 10.5
trans-1,2-CPDA: 10.4
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

NZ_JALDPQ010000052.1 - Region 1 - NRPS,T1PKS

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Location: 78,717 - 131,271 nt. (total: 52,555 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

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regulatory genes

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resistance

TTA codons

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Select a gene to view the details available for it

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TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

MQC87_RS09740: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

MQC87_RS09795: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

MQC87_RS09860: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

MQC87_RS09880: dehydrogenase

smcogs: SMCOG1072: dehydrogenase

Hydrolases: hydrolase

MQC87_RS09875: HAD-superfamily hydrolase, subfamily IA, variant

smcogs: SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

Ligases: synthase

MQC87_RS09830: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Translocases: transporter

MQC87_RS09895: sugar-binding lipoprotein

smcogs: SMCOG1143: sugar-binding lipoprotein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000307.4	0.61	NRPS	AbT1	Aureobasidium pullulans
BGC0001758.4	0.59	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.4	0.57	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002276.2	0.54	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001160.5	0.53	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.53	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002099.3	0.47	ribosomal	biarylitide YFH	Planomonospora sp. ID107089
BGC0002084.4	0.47	ribosomal	biarylitide YYH	Planomonospora sp. ID82291
BGC0002631.2	0.41	ribosomal	Myxarylin	Pyxidicoccus fallax
BGC0002518.3	0.37	NRPS	syringafactin A, syringafactin C	Pseudomonas sp. SZ57

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000307.4	0.64	NRPS	AbT1	Aureobasidium pullulans
BGC0001758.4	0.63	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.4	0.62	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002276.2	0.61	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001160.5	0.60	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.60	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002099.3	0.57	ribosomal	biarylitide YFH	Planomonospora sp. ID107089
BGC0002084.4	0.57	ribosomal	biarylitide YYH	Planomonospora sp. ID82291
BGC0002631.2	0.53	ribosomal	Myxarylin	Pyxidicoccus fallax
BGC0002518.3	0.50	NRPS	syringafactin A, syringafactin C	Pseudomonas sp. SZ57

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.94 out of 20.01

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.31 out of 23.79

Confidence: medium

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 26.90 out of 30.12

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.92 out of 20.47

Confidence: medium

Additional weak hits (12):

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 14.96 out of 27.78

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.49 out of 39.62

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.63 out of 27.78

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.47 out of 26.33

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 24.13 out of 30.22

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.68 out of 32.93

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 20.01 out of 35.63

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.53 out of 28.14

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.59 out of 22.40

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.07 out of 21.84

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.64 out of 21.84

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.96 out of 32.93

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 78716 - 131271:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (NH2 - ohmal - X)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

MQC87_RS09830: NH2 - mal - X

CAL_domain (122..451): NH2

minowa: NH2

Prediction, score:

NH2: 43.7
fatty_acid: 36.4
shikimic_acid: 0.0
Acetyl-CoA: 0.0
AHBA: 0.0

PKS_AT (1239..1521): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; inactive: 66.7%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 124.3
Methylmalonyl-CoA: 73.2
Methoxymalonyl-CoA: 68.5
inactive: 52.1
Propionyl-CoA: 40.9
fatty_acid: 35.0
Ethylmalonyl-CoA: 31.7
2-Methylbutyryl-CoA: 29.4
Isobutyryl-CoA: 28.8
trans-1,2-CPDA: 24.1
CHC-CoA: 17.7
Acetyl-CoA: 13.6
Benzoyl-CoA: 11.1
3-Methylbutyryl-CoA: 0.0

AMP-binding (2704..3124): X

nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: YWAAFDASVRQASSHVGGEANLYGPTEATINTSC
Nearest Stachelhaus code(s):: Gln DACSTGVINK (50% 8Å match)
Stachelhaus code match:: 70% (weak)

TFBS definitions

Regulator	Description
ArgR	Regulator of arginine biosynthesis genes
IolR	Regulator of the inositol catabolism
OsdR	Development and stress management regulator
VqsM	Regulator of quorum-sensing signalling systems

NZ_JALDPQ010000054.1 - Region 1 - terpene-precursor

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Location: 1 - 18,111 nt. (total: 18,111 nt) Show pHMM detection rules used

Region on contig edge.

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

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Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase

MQC87_RS10520: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Transferases: PPTase transferase

MQC87_RS10460: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

MQC87_RS10465: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Ligases: synthetase

MQC87_RS10490: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002631.2	0.54	ribosomal	Myxarylin	Pyxidicoccus fallax
BGC0000902.4	0.46	PKS	flaviolin	Saccharopolyspora erythraea NRRL 2338
BGC0000844.5	0.46	other (other)	clavulanic acid	Streptomyces clavuligerus
BGC0000677.5	0.46	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0001224.5	0.45	other (other)	reductasporine	uncultured bacterium
BGC0002031.3	0.44	other (other)	kitasetaline	Kitasatospora setae KM-6054
BGC0000528.5	0.43	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001910.4	0.42	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0001911.3	0.41	terpene	raimonol	Streptomyces anulatus
BGC0000285.5	0.41	PKS, saccharide	flaviolin, flaviolin rhamnoside, 3,3'-diflaviolin	Saccharopolyspora erythraea

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002631.2	0.54	ribosomal	Myxarylin	Pyxidicoccus fallax
BGC0000902.4	0.46	PKS	flaviolin	Saccharopolyspora erythraea NRRL 2338
BGC0000844.5	0.46	other (other)	clavulanic acid	Streptomyces clavuligerus
BGC0000677.5	0.46	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0001224.5	0.45	other (other)	reductasporine	uncultured bacterium
BGC0002031.3	0.44	other (other)	kitasetaline	Kitasatospora setae KM-6054
BGC0000528.5	0.43	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001910.4	0.42	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0001911.3	0.41	terpene	raimonol	Streptomyces anulatus
BGC0000285.5	0.41	PKS, saccharide	flaviolin, flaviolin rhamnoside, 3,3'-diflaviolin	Saccharopolyspora erythraea

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

MQC87_RS10490: PT_FPPS_like

Domain 1 (46 - 348): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 22.22 out of 27.04

Confidence: medium

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 22.24 out of 27.04

Confidence: medium

Additional weak hits (3):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.06 out of 26.33

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.42 out of 29.65

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 22.96 out of 30.11

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
DasR	N-acetylglucosamine dependent repressor

NZ_JALDPQ010000054.1 - Region 2 - lanthipeptide-class-ii

BGC0002110.3 (QKV49893.1):

Download region SVG

Location: 106,662 - 132,962 nt. (total: 26,301 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

MQC87_RS10985: NADH:flavin oxidoreductase/NADH oxidase

smcogs: SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

Lyases: cyclase hydratase

MQC87_RS11010: Nitrilase/cyanide hydratase and apolipoprotein

smcogs: SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein

MQC87_RS11025: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

MQC87_RS11035: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001229.4	0.61	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000554.4	0.56	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002110.3	0.55	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000528.5	0.55	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0002346.3	0.54	ribosomal	kyamicin	Saccharopolyspora sp.
BGC0000525.5	0.53	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0001311.5	0.52	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0000517.4	0.52	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0001391.3	0.51	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000552.3	0.50	ribosomal	SmbA, SmbB	Streptococcus mutans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001229.4	0.61	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000554.4	0.56	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002110.3	0.55	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000528.5	0.55	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0002346.3	0.54	ribosomal	kyamicin	Saccharopolyspora sp.
BGC0000525.5	0.53	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0001311.5	0.52	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0000517.4	0.52	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0001391.3	0.51	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000552.3	0.50	ribosomal	SmbA, SmbB	Streptococcus mutans

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for MQC87_RS11025

MQC87_RS11020

Leader:

MANPNVGILEEIDDQNLDAVSAA

Core:

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

Core with dehydrations:

GQGWGDhbIVDhaDhaLDhaCysYGADhaYVLGNNGNFCysDhbADhbAECysQNNCysK

antiSMASH-DB 4.0 matches for MQC87_RS11020

100.0%

NZ_BMRY01000003.1and 24 others:

NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12370_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS18205_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide

Lanthipeptides: IE140_RS12370_lanthipeptide

1

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

1

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

94.7%

NZ_CP116355.1and 1 other:

NZ_CP116355.1 Lanthipeptides: KPP03845_RS17815_lanthipeptide

Lanthipeptides: KPP03845_RS17815_lanthipeptide

1

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

GQGWGT++SSLSCYGASYVLGNNGNFCTATAECQNNCK

1

GQGWGTVMSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

89.5%

NZ_WHOM01000078.1and 1 other:

NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29300_lanthipeptide

Lanthipeptides: GCN81_RS29300_lanthipeptide

1

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

GQGWGT +SSLSCYGASYVLGNNGNFCTATAECQ+NC+

1

GQGWGTTLSSLSCYGASYVLGNNGNFCTATAECQSNCQ

38

with 112 more sequence matches

Only the first 10 are displayed here.

71.1%

NZ_QKTG01000020.1and 1 other:

NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS16920_lanthipeptide

Lanthipeptides: DEI99_RS16920_lanthipeptide

2

QGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

QG GT V++LSCYG S+ LGN+GNFCTAT ECQ+NCK

1

QGIGTTVTTLSCYGVSWALGNDGNFCTATVECQSNCK

37

66.7%

NZ_JALGRP010000007.1and 1 other:

NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12955_lanthipeptide

Lanthipeptides: MT347_RS12955_lanthipeptide

1

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNC

37

GQGW T ++SL+CYG S+V GNNG CTAT ECQNNC

2

GQGWTTTITSLTCYGVSWVAGNNGQVCTATVECQNNC

38

55.3%

NZ_LT575476.1and 1 other:

NZ_LT575476.1 Lanthipeptides: BN6628_RS02285_lanthipeptide

Lanthipeptides: BN6628_RS02285_lanthipeptide

4

WGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

WGT++++L+C GASY LG+ G CTAT EC NNC+

3

WGTVLTTLACLGASYALGDKGQVCTATVECINNCR

37

52.6%

NZ_BCEY01000006.1and 1 other:

NZ_BCEY01000006.1 Lanthipeptides: GOZ53_RS01290_lanthipeptide

Lanthipeptides: GOZ53_RS01290_lanthipeptide

3

GW-GTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

GW G S +SC S+ LGN+G CT TAECQ CK

1

GWTGVAKSIVSCSLISFALGNDGWICTWTAECQATCK

37

50.0%

NZ_JALIRS010000003.1and 3 others:

NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07255_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide

Lanthipeptides: MOK21_RS07255_lanthipeptide

2

QGWG-TIVSSLSCYGASYVLGNNGNFCTATAECQNNC

37

+ W TI++SL+C ASY+LGN G+ CT T ECQ C

3

ERWAETILTSLACAAASYILGNPGHVCTLTVECQKKC

39

50.0%

NZ_JAQFWW010000002.1and 1 other:

NZ_JAQFWW010000002.1 Lanthipeptides: PDT38_RS11330_lanthipeptide

Lanthipeptides: PDT38_RS11330_lanthipeptide

4

WGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

WGT++++LSC AS ++G+ G CT T ECQNNC+

3

WGTLLTTLSCLAASIMIGDKGQVCTGTVECQNNCR

37

47.4%

NC_015215.1and 5 others:

NC_015215.1 Lanthipeptides: SGGBAA2069_RS00705_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09795_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09795_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05350_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05350_lanthipeptide

Lanthipeptides: SGGBAA2069_RS00705_lanthipeptide

3

GWGTIVSSL-SCYGASYVLGNNGNFCTATAECQNNCK

38

GW + S+ SC S LGN+G CT TAECQ C+

1

GWTGVAKSITSCSLLSIGLGNDGWVCTWTAECQATCR

37

47.4%

NC_017299.1and 1 other:

NC_017299.1 Lanthipeptides: H04402_RS03105_lanthipeptide

Lanthipeptides: H04402_RS03105_lanthipeptide

5

GTIVSSLSCYGASYVLGNNGNFCTATAECQNNC

37

GTI +LS Y +GN+G CT T ECQNNC

5

GTISITLSVY-----MGNDGKVCTWTVECQNNC

32

47.4%

NZ_WITJ01000001.1and 1 other:

NZ_WITJ01000001.1 Lanthipeptides: GHI93_RS00065_lanthipeptide

Lanthipeptides: GHI93_RS00065_lanthipeptide

1

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

G W + SS+ + LGNNG CT T ECQ NCK

1

GWTWNLVFSSV----VTLALGNNGYVCTWTHECQANCK

34

44.7%

NZ_BMVL01000013.1and 1 other:

NZ_BMVL01000013.1 Lanthipeptides: IE257_RS28650_lanthipeptide

Lanthipeptides: IE257_RS28650_lanthipeptide

6

TIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

TI +++ AS+ LGNNG+ CT T ECQ NC+

1

TIFETVTYTVASWALGNNGHLCTVTVECQKNCQ

33

MIBiG 4.0 matches for MQC87_RS11020

36.8%

Lanthipeptide: birimositide

14

YGASYVLGNNGNFCTATAECQNNC

37

+ S LGNNG +CT T ECQ NC

6

FSLSNALGNNGGWCTLTKECQPNC

29

31.6%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

14

YGASYVLGNNGNFCTATAECQNNC

37

Y S LGN G +CT T EC +C

4

YNISCRLGNKGAYCTLTVECMPSC

27

17.9%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

27

CTATAECQNNC

37

CT + ECQ NC

28

CTLSKECQPNC

38

MQC87_RS11030

Leader:

MGDIAMNDATGYVSADELVELADA

Core:

PESLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

Core with dehydrations:

PEDhaLAAGFDhbPDhbIIPADhbAVDhbDhbVIVGADhaAAMQGGCysPDhbDhaGCysDhbKRCys

antiSMASH-DB 4.0 matches for MQC87_RS11030

100.0%

NZ_BNBJ01000003.1and 9 others:

NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05295_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19415_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19415_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11030_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11030_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32890_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32890_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100135_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100135_lanthipeptide

Lanthipeptides: IE304_RS05295_lanthipeptide

1

PESLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

PESLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

1

PESLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

97.6%

NZ_BMRY01000003.1and 9 others:

NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12360_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34975_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34975_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS0123035_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS0123035_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18445_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18445_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03745_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03745_lanthipeptide

Lanthipeptides: IE140_RS12360_lanthipeptide

1

PESLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

P+SLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

1

PDSLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

92.9%

NZ_BMSZ01000006.1and 4 others:

NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12790_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS18195_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19730_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19730_lanthipeptide

Lanthipeptides: IE135_RS12790_lanthipeptide

1

PESLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

P+SLAAG TPTI+PATAVTTVIVGASAAMQGGCPTSGCTKRC

1

PDSLAAGITPTIVPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

with 80 more sequence matches

Only the first 10 are displayed here.

83.3%

NZ_WHOM01000078.1and 1 other:

NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29290_lanthipeptide

Lanthipeptides: GCN81_RS29290_lanthipeptide

1

PESLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

PESLAAG TPTI+PAT V IVGASAA+QGGCPTSGCTKRC

1

PESLAAGITPTILPATGV---IVGASAALQGGCPTSGCTKRC

39

42.9%

NZ_CKMQ01000043.1and 8 others:

NZ_CKMQ01000043.1 Lanthipeptides: AE832_RS09950_lanthipeptideNZ_CKMR01000002.1 Lanthipeptides: AD782_RS02065_lanthipeptideNZ_CKMR01000002.1 Lanthipeptides: AD782_RS02065_lanthipeptideNZ_FIXU01000003.1 Lanthipeptides: A1M11_RS01730_lanthipeptideNZ_FIXU01000003.1 Lanthipeptides: A1M11_RS01730_lanthipeptideNZ_LR216041.1 Lanthipeptides: E0F00_RS05470_lanthipeptideNZ_LR216046.1 Lanthipeptides: E0E82_RS05985_lanthipeptideNZ_LR216046.1 Lanthipeptides: E0E82_RS05985_lanthipeptide

Lanthipeptides: AE832_RS09950_lanthipeptide

9

TPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

TPTIIPAT + G CPTSGCTK C

2

TPTIIPATISFVGVTFTVTLNAGACPTSGCTKSC

35

42.9%

NZ_CP015591.1and 15 others:

NZ_CP078085.1 Lanthipeptides: KU891_RS29355_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29350_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29345_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29340_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29335_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptide

Lanthipeptides: A7A70_RS27550_lanthipeptide

1

PESLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

PE+ A TPTI+ AT TV + CPT+ CT RC

5

PETTPA--TPTIVEATIAATVSI---------CPTTKCTSRC

35

40.5%

NZ_CM000756.1and 17 others:

NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptideNZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14765_lanthipeptideNZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptide

Lanthipeptides: BTHUR0011_RS14765_lanthipeptide

2

ESLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

ES AG TP I+ A + T + Q CPTS C+K C

1

ESSGAG-TPAIVTAISAVTAVTA-----QSPCPTSACSKSC

35

40.5%

NZ_CP017953.1and 15 others:

NZ_CP017953.1 Lanthipeptides: BAMY_RS16390_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06470_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06470_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15890_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15890_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05695_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05695_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16180_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16180_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16150_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16150_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11805_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11805_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06815_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06815_lanthipeptide

Lanthipeptides: BAMY_RS16390_lanthipeptide

9

TPTIIPATAV----TTVIVGASAAMQGGCPTSGCTKRC

42

TPT++ + TT V SAA CPTS CTK+C

2

TPTVVLTATIGLTGTTFTVTLSAA---SCPTSACTKQC

36

40.5%

NZ_PNGD01000001.1and 1 other:

NZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00165_lanthipeptide

Lanthipeptides: CJ239_RS00165_lanthipeptide

9

TPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

TPTII AT + G CPTSGCTK C

2

TPTIIAATISFAGVTFTVTLNAGACPTSGCTKSC

35

38.1%

NZ_BLIS01000009.1and 1 other:

NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04825_lanthipeptide

Lanthipeptides: GVO03_RS04825_lanthipeptide

1

PESLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

P S A +TP I T V A+ CPTS CT+ C

3

PASPATPYTPAIGKGVIAVTAFVSANT-----CPTSACTRAC

39

37.5%

NZ_LT575476.1and 1 other:

NZ_LT575476.1 Lanthipeptides: BN6628_RS02295_lanthipeptide

Lanthipeptides: BN6628_RS02295_lanthipeptide

2

ESLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

E + G+TP AT V +VI A CPTS CTK C

13

EDVKGGWTPV---ATVVISVIGLTMNATP--CPTSACTKSC

48

35.7%

NZ_CACZYW010000004.1and 3 others:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide

Lanthipeptides: HUF10_RS02820_lanthipeptide

14

PATAVTTVIVGASAAMQGG-CPTSGCTKRC

42

PAT T VIV SA + CPT+ CT+ C

3

PATPATPVIVAVSAYVSDKTCPTTACTRAC

32

35.7%

NZ_CP061868.1and 1 other:

NZ_CP061868.1 Lanthipeptides: IE339_RS06335_lanthipeptide

Lanthipeptides: IE339_RS06335_lanthipeptide

8

FTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

TPTI+ TAVT I CPT+ CT+ C

1

ITPTIV-ITAVTGYI------STNTCPTTSCTRAC

28

MIBiG 4.0 matches for MQC87_RS11030

31.0%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

21

VIVGASAAMQGGCPTSGCTKRC

42

V VG SAA CPT+ CT RC

19

VAVGVSAAF---CPTTKCTSRC

37

16.7%

BGC0002130.3 (QKI29070.1):

Lanthipeptide: cacaoidin

14

PATAVTTVIVGASAAMQGGC

33

P T +V SA GC

4

PCTIYASVSASISATASWGC

23

14.3%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

33

CPTSGCTKRC

42

CPT+ CT +C

17

CPTTKCTSKC

26

allorf_114966_115073

Leader:

MPERSGNVRFG

Core:

PCRNVPAVSVPSARTPPPWNWSCV

Core with dehydrations:

PCysRNVPAVDhaVPDhaARDhbPPPWNWDhaCysV

antiSMASH-DB 4.0 matches for allorf_114966_115073

100.0%

NZ_JALDPQ010000054.1and 1 other:

NZ_JALDPQ010000054.1 Lanthipeptides: allorf_114966_115073_lanthipeptide

Lanthipeptides: allorf_114966_115073_lanthipeptide

1

PCRNVPAVSVPSARTPPPWNWSCV

24

PCRNVPAVSVPSARTPPPWNWSCV

1

PCRNVPAVSVPSARTPPPWNWSCV

24

29.2%

NZ_BMSZ01000006.1and 2 others:

NZ_BMSZ01000006.1 Lanthipeptides: allorf_235964_236128_lanthipeptideNZ_CP021707.1 Lanthipeptides: allorf_3962821_3962985_lanthipeptide

Lanthipeptides: allorf_235964_236128_lanthipeptide

15

TPPPWNWSCV

24

+P PWN SCV

13

SPRPWNRSCV

22

25.9%

BGC0002110.3 (QKV49893.1):

Lanthipeptides: HW560_RS06640_lanthipeptide

8

VSVPSARTPPPWNWSC

23

VS +A P W W C

12

VSTITADCTPGWTWVC

27

with 3 more sequence matches

25.0%

NZ_GL877172.1:

Lanthipeptides: allorf_5847948_5848169_lanthipeptide

1

PCRNVPAVSVPSARTPPPWNW

21

P VPA + P+A PPP +

15

PGARVPAGTAPAALNPPPGPY

35

18.2%

NZ_BMRY01000003.1and 5 others:

NZ_BMRY01000003.1 Lanthipeptides: allorf_458543_458737_lanthipeptideNZ_CP084357.1 Lanthipeptides: allorf_8050125_8050319_lanthipeptideNZ_CP084357.1 Lanthipeptides: allorf_8050125_8050319_lanthipeptideNZ_KZ819178.1 Lanthipeptides: allorf_4075416_4075610_lanthipeptideNZ_KZ819178.1 Lanthipeptides: allorf_4075416_4075610_lanthipeptide

Lanthipeptides: allorf_458543_458737_lanthipeptide

15

TPPPWNWSCV

24

+P PWNWSCV

35

SPRPWNWSCV

44

16.2%

NZ_CP085876.1:

Lanthipeptides: allorf_0058816_0059013_lanthipeptide

1

PCRNVPAVSVPSARTPPPW

19

P +P++ +PS + P P+

18

PYFQLPSICLPSVQAPHPF

36

allorf_114997_115104

Leader:

MRAEGTDTAGT

Core:

FRHGPNLTLPERSGNPPHRACPNV

Core with dehydrations:

FRHGPNLDhbLPERDhaGNPPHRACysPNV

antiSMASH-DB 4.0 matches for allorf_114997_115104

100.0%

NZ_JALDPQ010000054.1and 1 other:

NZ_JALDPQ010000054.1 Lanthipeptides: allorf_114997_115104_lanthipeptide

Lanthipeptides: allorf_114997_115104_lanthipeptide

1

FRHGPNLTLPERSGNPPHRACPNV

24

FRHGPNLTLPERSGNPPHRACPNV

1

FRHGPNLTLPERSGNPPHRACPNV

24

29.2%

NZ_CP080269.1:

Lassopeptides: KXU80_RS08620_lassopeptide

4

GPNLTLPERSGNPPHRACP

22

GPN +P+++G H P

1

GPNGVIPDKNGKGGHNNHP

19

25.0%

NZ_CM000743.1:

Lanthipeptides: allorf_5304622_5304729_lanthipeptide

1

FRHGPNLTLPERSGNPPHRAC

21

H PN+ ++ PH +C

3

LAHEPNILEYRKTKISPHHSC

23

with 2 more sequence matches

15.0%

NZ_BBZG01000001.1and 1 other:

NZ_FOBF01000002.1 Lanthipeptides: allorf_603810_604049_lanthipeptide

Lanthipeptides: allorf_1402466_1402705_lanthipeptide

2

RHGPNLTLPERSGNPPHRACP

22

R P P RS PPH + P

4

RGTPRCAFPARSPRPPHASVP

24

11.5%

NZ_CP047146.1:

Lanthipeptides: allorf_3674152_3674370_lanthipeptide

12

RSGNPPHRACPNV

24

RSG+ P R C +

8

RSGSIPWRICREI

20

Lanthipeptide(s) for MQC87_RS11035

MQC87_RS11020

Leader:

MANPNVGILEEIDDQNLDAVSAA

Core:

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

Core with dehydrations:

GQGWGDhbIVDhaDhaLDhaCysYGADhaYVLGNNGNFCysDhbADhbAECysQNNCysK

antiSMASH-DB 4.0 matches for MQC87_RS11020

100.0%

NZ_BMRY01000003.1and 24 others:

NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12370_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS18205_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide

Lanthipeptides: IE140_RS12370_lanthipeptide

1

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

1

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

94.7%

NZ_CP116355.1and 1 other:

NZ_CP116355.1 Lanthipeptides: KPP03845_RS17815_lanthipeptide

Lanthipeptides: KPP03845_RS17815_lanthipeptide

1

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

GQGWGT++SSLSCYGASYVLGNNGNFCTATAECQNNCK

1

GQGWGTVMSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

89.5%

NZ_WHOM01000078.1and 1 other:

NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29300_lanthipeptide

Lanthipeptides: GCN81_RS29300_lanthipeptide

1

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

GQGWGT +SSLSCYGASYVLGNNGNFCTATAECQ+NC+

1

GQGWGTTLSSLSCYGASYVLGNNGNFCTATAECQSNCQ

38

with 112 more sequence matches

Only the first 10 are displayed here.

71.1%

NZ_QKTG01000020.1and 1 other:

NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS16920_lanthipeptide

Lanthipeptides: DEI99_RS16920_lanthipeptide

2

QGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

QG GT V++LSCYG S+ LGN+GNFCTAT ECQ+NCK

1

QGIGTTVTTLSCYGVSWALGNDGNFCTATVECQSNCK

37

66.7%

NZ_JALGRP010000007.1and 1 other:

NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12955_lanthipeptide

Lanthipeptides: MT347_RS12955_lanthipeptide

1

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNC

37

GQGW T ++SL+CYG S+V GNNG CTAT ECQNNC

2

GQGWTTTITSLTCYGVSWVAGNNGQVCTATVECQNNC

38

55.3%

NZ_LT575476.1and 1 other:

NZ_LT575476.1 Lanthipeptides: BN6628_RS02285_lanthipeptide

Lanthipeptides: BN6628_RS02285_lanthipeptide

4

WGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

WGT++++L+C GASY LG+ G CTAT EC NNC+

3

WGTVLTTLACLGASYALGDKGQVCTATVECINNCR

37

52.6%

NZ_BCEY01000006.1and 1 other:

NZ_BCEY01000006.1 Lanthipeptides: GOZ53_RS01290_lanthipeptide

Lanthipeptides: GOZ53_RS01290_lanthipeptide

3

GW-GTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

GW G S +SC S+ LGN+G CT TAECQ CK

1

GWTGVAKSIVSCSLISFALGNDGWICTWTAECQATCK

37

50.0%

NZ_JALIRS010000003.1and 3 others:

NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07255_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptideNZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide

Lanthipeptides: MOK21_RS07255_lanthipeptide

2

QGWG-TIVSSLSCYGASYVLGNNGNFCTATAECQNNC

37

+ W TI++SL+C ASY+LGN G+ CT T ECQ C

3

ERWAETILTSLACAAASYILGNPGHVCTLTVECQKKC

39

50.0%

NZ_JAQFWW010000002.1and 1 other:

NZ_JAQFWW010000002.1 Lanthipeptides: PDT38_RS11330_lanthipeptide

Lanthipeptides: PDT38_RS11330_lanthipeptide

4

WGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

WGT++++LSC AS ++G+ G CT T ECQNNC+

3

WGTLLTTLSCLAASIMIGDKGQVCTGTVECQNNCR

37

47.4%

NC_015215.1and 5 others:

NC_015215.1 Lanthipeptides: SGGBAA2069_RS00705_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09795_lanthipeptideNZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09795_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05350_lanthipeptideNZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05350_lanthipeptide

Lanthipeptides: SGGBAA2069_RS00705_lanthipeptide

3

GWGTIVSSL-SCYGASYVLGNNGNFCTATAECQNNCK

38

GW + S+ SC S LGN+G CT TAECQ C+

1

GWTGVAKSITSCSLLSIGLGNDGWVCTWTAECQATCR

37

47.4%

NC_017299.1and 1 other:

NC_017299.1 Lanthipeptides: H04402_RS03105_lanthipeptide

Lanthipeptides: H04402_RS03105_lanthipeptide

5

GTIVSSLSCYGASYVLGNNGNFCTATAECQNNC

37

GTI +LS Y +GN+G CT T ECQNNC

5

GTISITLSVY-----MGNDGKVCTWTVECQNNC

32

47.4%

NZ_WITJ01000001.1and 1 other:

NZ_WITJ01000001.1 Lanthipeptides: GHI93_RS00065_lanthipeptide

Lanthipeptides: GHI93_RS00065_lanthipeptide

1

GQGWGTIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

G W + SS+ + LGNNG CT T ECQ NCK

1

GWTWNLVFSSV----VTLALGNNGYVCTWTHECQANCK

34

44.7%

NZ_BMVL01000013.1and 1 other:

NZ_BMVL01000013.1 Lanthipeptides: IE257_RS28650_lanthipeptide

Lanthipeptides: IE257_RS28650_lanthipeptide

6

TIVSSLSCYGASYVLGNNGNFCTATAECQNNCK

38

TI +++ AS+ LGNNG+ CT T ECQ NC+

1

TIFETVTYTVASWALGNNGHLCTVTVECQKNCQ

33

MIBiG 4.0 matches for MQC87_RS11020

36.8%

Lanthipeptide: birimositide

14

YGASYVLGNNGNFCTATAECQNNC

37

+ S LGNNG +CT T ECQ NC

6

FSLSNALGNNGGWCTLTKECQPNC

29

31.6%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

14

YGASYVLGNNGNFCTATAECQNNC

37

Y S LGN G +CT T EC +C

4

YNISCRLGNKGAYCTLTVECMPSC

27

17.9%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

27

CTATAECQNNC

37

CT + ECQ NC

28

CTLSKECQPNC

38

MQC87_RS11030

Leader:

MGDIAMNDATGYVSADELVELADA

Core:

PESLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

Core with dehydrations:

PEDhaLAAGFDhbPDhbIIPADhbAVDhbDhbVIVGADhaAAMQGGCysPDhbDhaGCysDhbKRCys

antiSMASH-DB 4.0 matches for MQC87_RS11030

100.0%

NZ_BNBJ01000003.1and 9 others:

NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05295_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19415_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS19415_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11030_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11030_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32890_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32890_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100135_lanthipeptideNZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100135_lanthipeptide

Lanthipeptides: IE304_RS05295_lanthipeptide

1

PESLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

PESLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

1

PESLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

97.6%

NZ_BMRY01000003.1and 9 others:

NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12360_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34975_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS34975_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS0123035_lanthipeptideNZ_JNLT01000014.1 Lanthipeptides: CD02_RS0123035_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18445_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS18445_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03745_lanthipeptideNZ_NNBN01000001.1 Lanthipeptides: CG717_RS03745_lanthipeptide

Lanthipeptides: IE140_RS12360_lanthipeptide

1

PESLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

P+SLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

1

PDSLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

92.9%

NZ_BMSZ01000006.1and 4 others:

NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12790_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS18195_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19730_lanthipeptideNZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19730_lanthipeptide

Lanthipeptides: IE135_RS12790_lanthipeptide

1

PESLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

P+SLAAG TPTI+PATAVTTVIVGASAAMQGGCPTSGCTKRC

1

PDSLAAGITPTIVPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

with 80 more sequence matches

Only the first 10 are displayed here.

83.3%

NZ_WHOM01000078.1and 1 other:

NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29290_lanthipeptide

Lanthipeptides: GCN81_RS29290_lanthipeptide

1

PESLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

PESLAAG TPTI+PAT V IVGASAA+QGGCPTSGCTKRC

1

PESLAAGITPTILPATGV---IVGASAALQGGCPTSGCTKRC

39

42.9%

NZ_CKMQ01000043.1and 8 others:

NZ_CKMQ01000043.1 Lanthipeptides: AE832_RS09950_lanthipeptideNZ_CKMR01000002.1 Lanthipeptides: AD782_RS02065_lanthipeptideNZ_CKMR01000002.1 Lanthipeptides: AD782_RS02065_lanthipeptideNZ_FIXU01000003.1 Lanthipeptides: A1M11_RS01730_lanthipeptideNZ_FIXU01000003.1 Lanthipeptides: A1M11_RS01730_lanthipeptideNZ_LR216041.1 Lanthipeptides: E0F00_RS05470_lanthipeptideNZ_LR216046.1 Lanthipeptides: E0E82_RS05985_lanthipeptideNZ_LR216046.1 Lanthipeptides: E0E82_RS05985_lanthipeptide

Lanthipeptides: AE832_RS09950_lanthipeptide

9

TPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

TPTIIPAT + G CPTSGCTK C

2

TPTIIPATISFVGVTFTVTLNAGACPTSGCTKSC

35

42.9%

NZ_CP015591.1and 15 others:

NZ_CP078085.1 Lanthipeptides: KU891_RS29355_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29350_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29345_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29340_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29335_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptide

Lanthipeptides: A7A70_RS27550_lanthipeptide

1

PESLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

PE+ A TPTI+ AT TV + CPT+ CT RC

5

PETTPA--TPTIVEATIAATVSI---------CPTTKCTSRC

35

40.5%

NZ_CM000756.1and 17 others:

NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptideNZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14765_lanthipeptideNZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptide

Lanthipeptides: BTHUR0011_RS14765_lanthipeptide

2

ESLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

ES AG TP I+ A + T + Q CPTS C+K C

1

ESSGAG-TPAIVTAISAVTAVTA-----QSPCPTSACSKSC

35

40.5%

NZ_CP017953.1and 15 others:

NZ_CP017953.1 Lanthipeptides: BAMY_RS16390_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06470_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06470_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15890_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15890_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05695_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05695_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16180_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16180_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16150_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16150_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11805_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11805_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06815_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06815_lanthipeptide

Lanthipeptides: BAMY_RS16390_lanthipeptide

9

TPTIIPATAV----TTVIVGASAAMQGGCPTSGCTKRC

42

TPT++ + TT V SAA CPTS CTK+C

2

TPTVVLTATIGLTGTTFTVTLSAA---SCPTSACTKQC

36

40.5%

NZ_PNGD01000001.1and 1 other:

NZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00165_lanthipeptide

Lanthipeptides: CJ239_RS00165_lanthipeptide

9

TPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

TPTII AT + G CPTSGCTK C

2

TPTIIAATISFAGVTFTVTLNAGACPTSGCTKSC

35

38.1%

NZ_BLIS01000009.1and 1 other:

NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04825_lanthipeptide

Lanthipeptides: GVO03_RS04825_lanthipeptide

1

PESLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

P S A +TP I T V A+ CPTS CT+ C

3

PASPATPYTPAIGKGVIAVTAFVSANT-----CPTSACTRAC

39

37.5%

NZ_LT575476.1and 1 other:

NZ_LT575476.1 Lanthipeptides: BN6628_RS02295_lanthipeptide

Lanthipeptides: BN6628_RS02295_lanthipeptide

2

ESLAAGFTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

E + G+TP AT V +VI A CPTS CTK C

13

EDVKGGWTPV---ATVVISVIGLTMNATP--CPTSACTKSC

48

35.7%

NZ_CACZYW010000004.1and 3 others:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide

Lanthipeptides: HUF10_RS02820_lanthipeptide

14

PATAVTTVIVGASAAMQGG-CPTSGCTKRC

42

PAT T VIV SA + CPT+ CT+ C

3

PATPATPVIVAVSAYVSDKTCPTTACTRAC

32

35.7%

NZ_CP061868.1and 1 other:

NZ_CP061868.1 Lanthipeptides: IE339_RS06335_lanthipeptide

Lanthipeptides: IE339_RS06335_lanthipeptide

8

FTPTIIPATAVTTVIVGASAAMQGGCPTSGCTKRC

42

TPTI+ TAVT I CPT+ CT+ C

1

ITPTIV-ITAVTGYI------STNTCPTTSCTRAC

28

MIBiG 4.0 matches for MQC87_RS11030

31.0%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

21

VIVGASAAMQGGCPTSGCTKRC

42

V VG SAA CPT+ CT RC

19

VAVGVSAAF---CPTTKCTSRC

37

16.7%

BGC0002130.3 (QKI29070.1):

Lanthipeptide: cacaoidin

14

PATAVTTVIVGASAAMQGGC

33

P T +V SA GC

4

PCTIYASVSASISATASWGC

23

14.3%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

33

CPTSGCTKRC

42

CPT+ CT +C

17

CPTTKCTSKC

26

allorf_114966_115073

Leader:

MPERSGNVRFG

Core:

PCRNVPAVSVPSARTPPPWNWSCV

Core with dehydrations:

PCysRNVPAVDhaVPDhaARDhbPPPWNWDhaCysV

antiSMASH-DB 4.0 matches for allorf_114966_115073

100.0%

NZ_JALDPQ010000054.1and 1 other:

NZ_JALDPQ010000054.1 Lanthipeptides: allorf_114966_115073_lanthipeptide

Lanthipeptides: allorf_114966_115073_lanthipeptide

1

PCRNVPAVSVPSARTPPPWNWSCV

24

PCRNVPAVSVPSARTPPPWNWSCV

1

PCRNVPAVSVPSARTPPPWNWSCV

24

29.2%

NZ_BMSZ01000006.1and 2 others:

NZ_BMSZ01000006.1 Lanthipeptides: allorf_235964_236128_lanthipeptideNZ_CP021707.1 Lanthipeptides: allorf_3962821_3962985_lanthipeptide

Lanthipeptides: allorf_235964_236128_lanthipeptide

15

TPPPWNWSCV

24

+P PWN SCV

13

SPRPWNRSCV

22

25.9%

BGC0001639.3 (OUH62395.1):

Lanthipeptides: HW560_RS06640_lanthipeptide

8

VSVPSARTPPPWNWSC

23

VS +A P W W C

12

VSTITADCTPGWTWVC

27

with 3 more sequence matches

25.0%

NZ_GL877172.1:

Lanthipeptides: allorf_5847948_5848169_lanthipeptide

1

PCRNVPAVSVPSARTPPPWNW

21

P VPA + P+A PPP +

15

PGARVPAGTAPAALNPPPGPY

35

18.2%

NZ_BMRY01000003.1and 5 others:

NZ_BMRY01000003.1 Lanthipeptides: allorf_458543_458737_lanthipeptideNZ_CP084357.1 Lanthipeptides: allorf_8050125_8050319_lanthipeptideNZ_CP084357.1 Lanthipeptides: allorf_8050125_8050319_lanthipeptideNZ_KZ819178.1 Lanthipeptides: allorf_4075416_4075610_lanthipeptideNZ_KZ819178.1 Lanthipeptides: allorf_4075416_4075610_lanthipeptide

Lanthipeptides: allorf_458543_458737_lanthipeptide

15

TPPPWNWSCV

24

+P PWNWSCV

35

SPRPWNWSCV

44

16.2%

NZ_CP085876.1:

Lanthipeptides: allorf_0058816_0059013_lanthipeptide

1

PCRNVPAVSVPSARTPPPW

19

P +P++ +PS + P P+

18

PYFQLPSICLPSVQAPHPF

36

allorf_114997_115104

Leader:

MRAEGTDTAGT

Core:

FRHGPNLTLPERSGNPPHRACPNV

Core with dehydrations:

FRHGPNLDhbLPERDhaGNPPHRACysPNV

antiSMASH-DB 4.0 matches for allorf_114997_115104

100.0%

NZ_JALDPQ010000054.1and 1 other:

NZ_JALDPQ010000054.1 Lanthipeptides: allorf_114997_115104_lanthipeptide

Lanthipeptides: allorf_114997_115104_lanthipeptide

1

FRHGPNLTLPERSGNPPHRACPNV

24

FRHGPNLTLPERSGNPPHRACPNV

1

FRHGPNLTLPERSGNPPHRACPNV

24

29.2%

NZ_CP080269.1:

Lassopeptides: KXU80_RS08620_lassopeptide

4

GPNLTLPERSGNPPHRACP

22

GPN +P+++G H P

1

GPNGVIPDKNGKGGHNNHP

19

25.0%

NZ_CM000743.1:

Lanthipeptides: allorf_5304622_5304729_lanthipeptide

1

FRHGPNLTLPERSGNPPHRAC

21

H PN+ ++ PH +C

3

LAHEPNILEYRKTKISPHHSC

23

with 2 more sequence matches

15.0%

NZ_BBZG01000001.1and 1 other:

NZ_FOBF01000002.1 Lanthipeptides: allorf_603810_604049_lanthipeptide

Lanthipeptides: allorf_1402466_1402705_lanthipeptide

2

RHGPNLTLPERSGNPPHRACP

22

R P P RS PPH + P

4

RGTPRCAFPARSPRPPHASVP

24

11.5%

NZ_CP047146.1:

Lanthipeptides: allorf_3674152_3674370_lanthipeptide

12

RSGNPPHRACPNV

24

RSG+ P R C +

8

RSGSIPWRICREI

20

allorf_130072_130218

Leader:

MTPRHAARSQGS

Core:

FATTVRRFGRCPSEGGAEEFIPPGMPPYAISPLEVR

Core with dehydrations:

FADhbDhbVRRFGRCysPDhaEGGAEEFIPPGMPPYAIDhaPLEVR

antiSMASH-DB 4.0 matches for allorf_130072_130218

100.0%

NZ_BNBJ01000003.1and 3 others:

NZ_CP079114.1 Lanthipeptides: allorf_4422232_4422378_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: allorf_130072_130218_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: allorf_031162_031308_lanthipeptide

Lanthipeptides: allorf_023668_023814_lanthipeptide

1

FATTVRRFGRCPSEGGAEEFIPPGMPPYAISPLEVR

36

FATTVRRFGRCPSEGGAEEFIPPGMPPYAISPLEVR

1

FATTVRRFGRCPSEGGAEEFIPPGMPPYAISPLEVR

36

97.2%

NZ_BMSZ01000006.1:

Lanthipeptides: allorf_251197_251343_lanthipeptide

1

FATTVRRFGRCPSEGGAEEFIPPGMPPYAISPLEVR

36

FATTVRRFGRCPSEGGAEE IPPGMPPYAISPLEVR

1

FATTVRRFGRCPSEGGAEESIPPGMPPYAISPLEVR

36

94.4%

NZ_LZRD01000017.1:

Lanthipeptides: allorf_103132_103278_lanthipeptide

1

FATTVRRFGRCPSEGGAEEFIPPGMPPYAISPLEVR

36

FATTVRR GRCPSEGGAEE IPPGMPPYAISPLEVR

1

FATTVRRSGRCPSEGGAEESIPPGMPPYAISPLEVR

36

with 4 more sequence matches

24.3%

NZ_QLMA01000007.1:

Lanthipeptides: CLV59_RS20825_lanthipeptide

3

TTVRRFGRCPSEGGAEEFIPPG

24

TTV CP+ IPPG

9

TTVMSIRTCPTVVDTCSTIPPG

30

18.4%

NZ_FMXV01000009.1:

Lanthipeptides: allorf_148352_148558_lanthipeptide

8

FGRCPSEGGAEEFIPP

23

G CPS G +PP

20

IGHCPSAGHNARRLPP

35

16.7%

NZ_ML974127.1:

Lanthipeptides: EPL00_RS07380_lanthipeptide

10

RCPSEGGAEEFI

21

+CP GGA F+

19

KCPDCGGALTFV

30

13.9%

NZ_CP119804.1:

Lanthipeptides: allorf_1905850_1905972_lanthipeptide

5

VRRFGRCPSEGGAEE

19

+ RF RC S + +

3

INRFARCDSHHSSAD

17

MIBiG 4.0 matches for allorf_130072_130218

13.9%

Lasso peptide: klebsidin

13

SEGGAEEFIPP

23

S+G EF P

2

SDGPIIEFFNP

12

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 18.33 out of 19.52

Confidence: strong

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 18.39 out of 25.31

Confidence: medium

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.54 out of 18.46

Confidence: medium

Additional weak hits (3):

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.49 out of 19.26

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.12 out of 27.78

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 19.16 out of 29.25

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

MQC87_RS11020 - Class II

Cleavage pHMM score: -2.30

RODEO score: 0

Monoisotopic mass: 3790.7 Da

Molecular weight: 3793.1 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3811.2 Da N = 1; 3829.2 Da N = 2; 3847.2 Da N = 3

MQC87_RS11030 - Class II

Cleavage pHMM score: -3.80

RODEO score: 0

Monoisotopic mass: 3855.0 Da

Molecular weight: 3857.5 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3875.5 Da N = 1; 3893.5 Da N = 2; 3911.5 Da N = 3; 3929.5 Da N = 4; 3947.6 Da N = 5; 3965.6 Da N = 6; 3983.6 Da N = 7

allorf_114966_115073 - Class II

Cleavage pHMM score: -6.10

RODEO score: 0

Monoisotopic mass: 2547.3 Da

Molecular weight: 2548.9 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2566.9 Da N = 1; 2585.0 Da N = 2

allorf_114997_115104 - Class II

Cleavage pHMM score: -6.60

RODEO score: 0

Monoisotopic mass: 2629.3 Da

Molecular weight: 2630.9 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2649.0 Da N = 1

allorf_130072_130218 - Class II

Cleavage pHMM score: -5.40

RODEO score: 0

Monoisotopic mass: 3862.0 Da

Molecular weight: 3864.4 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3882.4 Da N = 1; 3900.4 Da N = 2; 3918.5 Da N = 3

MQC87_RS11020 - Class II

Cleavage pHMM score: -2.30

RODEO score: 0

Monoisotopic mass: 3790.7 Da

Molecular weight: 3793.1 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3811.2 Da N = 1; 3829.2 Da N = 2; 3847.2 Da N = 3

MQC87_RS11030 - Class II

Cleavage pHMM score: -3.80

RODEO score: 0

Monoisotopic mass: 3855.0 Da

Molecular weight: 3857.5 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3875.5 Da N = 1; 3893.5 Da N = 2; 3911.5 Da N = 3; 3929.5 Da N = 4; 3947.6 Da N = 5; 3965.6 Da N = 6; 3983.6 Da N = 7

allorf_114966_115073 - Class II

Cleavage pHMM score: -6.10

RODEO score: 0

Monoisotopic mass: 2547.3 Da

Molecular weight: 2548.9 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2566.9 Da N = 1; 2585.0 Da N = 2

allorf_114997_115104 - Class II

Cleavage pHMM score: -6.60

RODEO score: 0

Monoisotopic mass: 2629.3 Da

Molecular weight: 2630.9 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2649.0 Da N = 1

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
CatR	H2O2-responsive repressor
RpoN	Regulator of nitrogen assimilation and virulence

NZ_JALDPQ010000058.1 - Region 1 - butyrolactone,ectoine

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Location: 32,952 - 48,382 nt. (total: 15,431 nt) Show pHMM detection rules used

Region on contig edge.

ectoine: ectoine_synt
butyrolactone: AfsA

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

MQC87_RS12510: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

MQC87_RS12550: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: PPTase

MQC87_RS12530: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Ligases: ligase

MQC87_RS12495: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001778.5	0.55	other (other)	showdomycin	Streptomyces showdoensis
BGC0000849.4	0.48	other (butyrolactone)	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)
BGC0000848.5	0.48	other (other)	A-factor	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000850.5	0.33	other (other)	γ-butyrolactone	Streptomyces acidiscabies
BGC0000706.3	0.29	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0002276.2	0.26	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001641.4	0.25	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001723.5	0.25	PKS	oviedomycin	Streptomyces antibioticus
BGC0000003.3	0.24	PKS	AF-toxin	Alternaria alternata
BGC0002675.2	0.24	PKS	prodigiosin	Pseudoalteromonas rubra

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000849.4	0.77	other (butyrolactone)	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)
BGC0000848.5	0.77	other (other)	A-factor	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002276.2	0.61	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001778.5	0.58	other (other)	showdomycin	Streptomyces showdoensis
BGC0001641.4	0.58	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000850.5	0.58	other (other)	γ-butyrolactone	Streptomyces acidiscabies
BGC0002578.2	0.48	other (other)	gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F	Streptomyces venezuelae ATCC 10712
BGC0000231.5	0.47	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.45	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001723.5	0.45	PKS	oviedomycin	Streptomyces antibioticus

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.82 out of 18.46

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05

Confidence: medium

Additional weak hits (14):

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.38 out of 20.01

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 16.99 out of 30.97

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.74 out of 20.01

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.22 out of 20.01

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.04 out of 18.57

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 15.55 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.77 out of 29.38

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.22 out of 20.01

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.36 out of 20.01

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.53 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.30 out of 26.06

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.92 out of 30.22

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.24 out of 32.93

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.92 out of 28.14

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
RpoN	Regulator of nitrogen assimilation and virulence

NZ_JALDPQ010000059.1 - Region 1 - T3PKS

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Location: 35,765 - 76,817 nt. (total: 41,053 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

MQC87_RS12775: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

MQC87_RS12880: oxidoreductase

smcogs: SMCOG1161: oxidoreductase

Transferases: kinase methyltransferase

MQC87_RS12780: PfkB domain protein

smcogs: SMCOG1276: PfkB domain protein

MQC87_RS12885: Methylation

MITE: MITE0000155Methylation (identity: 90.20%)
smcogs: SMCOG1150: isoprenylcysteine carboxyl methyltransferase

Ligases: ligase synthase

MQC87_RS12830: carboxylate-amine ligase

smcogs: SMCOG1165: carboxylate-amine ligase

MQC87_RS12890: chalcone and stilbene synthase domain protein

smcogs: SMCOG1024: chalcone and stilbene synthase domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000282.3	0.89	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3	0.53	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001647.3	0.47	PKS	lagunapyrone A, lagunapyrone B, lagunapyrone C	Streptomyces sp. MP131-18
BGC0001964.2	0.45	PKS	alkylpyrone-407, alkylpyrone-393	Cystobacterineae bacterium
BGC0002362.3	0.45	PKS	loseolamycin A1, loseolamycin A2	Micromonospora endolithica
BGC0001927.4	0.44	other (other)	A-94964	Streptomyces sp.
BGC0001366.5	0.41	PKS	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2
BGC0001850.4	0.41	other (shikimate-derived)	diazaquinomycin A, diazaquinomycin E, diazaquinomycin F, diazaquinomycin G	Streptomyces sp. F001
BGC0001965.4	0.41	other (other)	nybomycin	Streptomyces albus subsp. chlorinus
BGC0002305.2	0.41	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000282.3	0.89	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3	0.53	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001647.3	0.47	PKS	lagunapyrone A, lagunapyrone B, lagunapyrone C	Streptomyces sp. MP131-18
BGC0001964.2	0.45	PKS	alkylpyrone-407, alkylpyrone-393	Cystobacterineae bacterium
BGC0002362.3	0.45	PKS	loseolamycin A1, loseolamycin A2	Micromonospora endolithica
BGC0001927.4	0.44	other (other)	A-94964	Streptomyces sp.
BGC0001366.5	0.41	PKS	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2
BGC0001850.4	0.41	other (shikimate-derived)	diazaquinomycin A, diazaquinomycin E, diazaquinomycin F, diazaquinomycin G	Streptomyces sp. F001
BGC0001965.4	0.41	other (other)	nybomycin	Streptomyces albus subsp. chlorinus
BGC0002305.2	0.41	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 27.19 out of 36.53

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.20 out of 23.79

Confidence: medium

Additional weak hits (3):

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 18.31 out of 36.54

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 13.81 out of 18.57

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.53 out of 21.55

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
DmdR1	Iron(II)-dependent repressor
IolR	Regulator of the inositol catabolism

NZ_JALDPQ010000059.1 - Region 2 - melanin,terpene-precursor

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Location: 93,422 - 121,914 nt. (total: 28,493 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)
melanin: melC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase oxygenase

MQC87_RS13085: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

MQC87_RS13185: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Transferases: glycosyltransferase

MQC87_RS13130: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

MQC87_RS13135: sugar transferase

smcogs: SMCOG1146: sugar transferase

MQC87_RS13155: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

Hydrolases: hydrolase

MQC87_RS13125: isochorismatase

smcogs: SMCOG1027: isochorismatase

Ligases: synthetase

MQC87_RS13120: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000911.3	0.63	other (other)	melanin	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000910.3	0.50	other (other)	melanin	Streptomyces coelicolor A3(2)
BGC0000909.3	0.30	other (other)	melanin	Streptomyces avermitilis
BGC0000912.3	0.26	other (other)	melanin	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000800.5	0.26	saccharide	xanthan	Xanthomonas campestris
BGC0001529.5	0.22	other (other)	benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K	Streptomyces sp. RI18
BGC0000786.3	0.21	saccharide	O-antigen	Edwardsiella ictaluri 93-146
BGC0000868.5	0.20	other (other)	teichuronic acid	Bacillus subtilis subsp. subtilis str. 168
BGC0000790.3	0.18	saccharide	O-antigen	Escherichia coli
BGC0000651.5	0.17	terpene	KS-505a	Streptomyces argenteolus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000911.3	0.86	other (other)	melanin	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000910.3	0.79	other (other)	melanin	Streptomyces coelicolor A3(2)
BGC0000909.3	0.64	other (other)	melanin	Streptomyces avermitilis
BGC0000912.3	0.59	other (other)	melanin	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002397.2	0.53	terpene	astallatene	Arabidopsis thaliana
BGC0000908.3	0.52	other (other)	melanin	Streptomyces avermitilis
BGC0000868.5	0.52	other (other)	teichuronic acid	Bacillus subtilis subsp. subtilis str. 168
BGC0002400.2	0.49	terpene	boleracene	Brassica oleracea var. oleracea
BGC0000677.5	0.48	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0000800.5	0.47	saccharide	xanthan	Xanthomonas campestris

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

MQC87_RS13120: PT_FPPS_like

Domain 1 (58 - 339): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.52 out of 23.79

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.92 out of 20.47

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.37 out of 20.47

Confidence: medium

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.00 out of 26.85

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.52 out of 23.79

Confidence: medium

Additional weak hits (4):

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.00 out of 28.14

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 18.35 out of 30.97

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.45 out of 30.25

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.19 out of 28.19

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
IolR	Regulator of the inositol catabolism
RutR	Regulator of the pyrimidine and purine metabolism
VqsM	Regulator of quorum-sensing signalling systems

NZ_JALDPQ010000059.1 - Region 3 - RiPP-like

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Location: 122,838 - 134,205 nt. (total: 11,368 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002115.3	0.74	ribosomal	streptamidine	Streptomyces albidoflavus J1074
BGC0002306.2	0.43	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000551.5	0.42	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000513.3	0.42	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0001639.3	0.41	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0001579.4	0.40	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0000616.4	0.39	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0000571.3	0.37	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001863.4	0.35	ribosomal, terpene	bacillicn CER074	Bacillus mycoides
BGC0002289.2	0.35	ribosomal	Leepeptin	Streptomyces leeuwenhoekii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002115.3	0.74	ribosomal	streptamidine	Streptomyces albidoflavus J1074
BGC0002306.2	0.43	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000551.5	0.42	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000513.3	0.42	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0001639.3	0.41	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0001579.4	0.40	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0000616.4	0.39	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0000571.3	0.37	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001863.4	0.35	ribosomal, terpene	bacillicn CER074	Bacillus mycoides
BGC0002289.2	0.35	ribosomal	Leepeptin	Streptomyces leeuwenhoekii

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.04 out of 23.79

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16

Confidence: strong

Additional weak hits (2):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.88 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 12.45 out of 28.14

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
IolR	Regulator of the inositol catabolism

NZ_JALDPQ010000059.1 - Region 4 - NRPS

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Location: 220,868 - 263,725 nt. (total: 42,858 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

MQC87_RS13790: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

MQC87_RS13810: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Transferases: acyltransferase

MQC87_RS13860: acyltransferase

smcogs: SMCOG1141: acyltransferase

Ligases: ligase

MQC87_RS13765: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001135.5	0.64	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002135.2	0.63	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000307.4	0.63	NRPS	AbT1	Aureobasidium pullulans
BGC0001166.5	0.63	NRPS	HC-toxin	Alternaria jesenskae
BGC0001240.4	0.62	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001758.4	0.62	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.4	0.62	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000342.4	0.62	NRPS	enniatin	Fusarium equiseti
BGC0001132.4	0.62	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.62	NRPS	icosalide A, icosalide B	Burkholderia gladioli

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001135.5	0.64	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002135.2	0.63	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000307.4	0.63	NRPS	AbT1	Aureobasidium pullulans
BGC0001166.5	0.63	NRPS	HC-toxin	Alternaria jesenskae
BGC0001240.4	0.62	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001758.4	0.62	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.4	0.62	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000342.4	0.62	NRPS	enniatin	Fusarium equiseti
BGC0001132.4	0.62	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.62	NRPS	icosalide A, icosalide B	Burkholderia gladioli

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (4):

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 20.57 out of 32.74

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.56 out of 21.55

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.74 out of 29.65

Confidence: weak

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 21.74 out of 29.72

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 6, location 220867 - 263725:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

MQC87_RS13765: X

AMP-binding (12..413): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LTATFDVAFLEMALMTGADVACYGLTEATVNSTL
Nearest Stachelhaus code(s):: Ac-OH-Orn DVWALGAVNK (85% 8Å match)
Stachelhaus code match:: 70% (weak)

TFBS definitions

Regulator	Description

NZ_JALDPQ010000059.1 - Region 5 - RiPP-like

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Location: 339,742 - 350,539 nt. (total: 10,798 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

MQC87_RS14235: 3-hydroxyisobutyrate dehydrogenase

smcogs: SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

Lyases: decarboxylase

MQC87_RS14255: diaminopimelate decarboxylase

smcogs: SMCOG1264: diaminopimelate decarboxylase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001778.5	0.37	other (other)	showdomycin	Streptomyces showdoensis
BGC0001575.4	0.34	NRPS	PZN5, PZN6, PZN7, PZN9, PZN10, PZN11	Ruminococcus sp. 5_1_39BFAA
BGC0001891.3	0.32	other (other)	closthioamide	Ruminiclostridium cellulolyticum H10
BGC0001285.5	0.32	other (fatty acid)	pseudopyronine A, pseudopyronine B	Pseudomonas putida
BGC0001882.3	0.31	PKS	chrysoxanthone A, chrysoxanthone B, chrysoxanthone C	Penicillium rubens Wisconsin 54-1255
BGC0000729.3	0.31	saccharide	capsular polysaccharide	Klebsiella pneumoniae
BGC0000728.5	0.31	saccharide	capsular polysaccharide	Klebsiella pneumoniae subsp. ozaenae
BGC0000975.5	0.30	NRPS, PKS	Cryptophycin A	Nostoc sp. ATCC 53789
BGC0000791.3	0.30	saccharide	O-antigen	Cronobacter sakazakii
BGC0000730.3	0.28	saccharide	capsular polysaccharide	Klebsiella pneumoniae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001778.5	0.37	other (other)	showdomycin	Streptomyces showdoensis
BGC0001575.4	0.34	NRPS	PZN5, PZN6, PZN7, PZN9, PZN10, PZN11	Ruminococcus sp. 5_1_39BFAA
BGC0001891.3	0.32	other (other)	closthioamide	Ruminiclostridium cellulolyticum H10
BGC0001285.5	0.32	other (fatty acid)	pseudopyronine A, pseudopyronine B	Pseudomonas putida
BGC0001882.3	0.31	PKS	chrysoxanthone A, chrysoxanthone B, chrysoxanthone C	Penicillium rubens Wisconsin 54-1255
BGC0000729.3	0.31	saccharide	capsular polysaccharide	Klebsiella pneumoniae
BGC0000728.5	0.31	saccharide	capsular polysaccharide	Klebsiella pneumoniae subsp. ozaenae
BGC0000975.5	0.30	NRPS, PKS	Cryptophycin A	Nostoc sp. ATCC 53789
BGC0000791.3	0.30	saccharide	O-antigen	Cronobacter sakazakii
BGC0000730.3	0.28	saccharide	capsular polysaccharide	Klebsiella pneumoniae

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.26 out of 19.26

Confidence: medium

Additional weak hits (2):

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.69 out of 20.97

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.04 out of 27.55

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein

NZ_JALDPQ010000061.1 - Region 1 - NRPS,NRPS-like,T1PKS,hglE-KS,terpene

Download region SVG

Location: 192,578 - 287,687 nt. (total: 95,110 nt) Show pHMM detection rules used

hglE-KS: (hglE or hglD)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

MQC87_RS16655: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

MQC87_RS16660: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

MQC87_RS16795: dehydrogenase

smcogs: SMCOG1072: dehydrogenase

MQC87_RS16830: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

MQC87_RS16840: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

MQC87_RS16915: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

Transferases: acylase aminotransferase glycosyltransferase kinase methyltransferase

MQC87_RS16635: glycerol kinase

smcogs: SMCOG1210: glycerol kinase

MQC87_RS16720: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

MQC87_RS16775: aminotransferase

smcogs: SMCOG1019: aminotransferase

MQC87_RS16820: aminotransferase class V

smcogs: SMCOG1139: aminotransferase class V

MQC87_RS16880: methyltransferase

smcogs: SMCOG1089: methyltransferase

MQC87_RS16895: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

MQC87_RS16900: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

Hydrolases: esterase

MQC87_RS16835: thioesterase

smcogs: SMCOG1004: thioesterase

MQC87_RS16845: thioesterase

smcogs: SMCOG1004: thioesterase

Lyases: dehydratase

MQC87_RS16715: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

MQC87_RS16750: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: ligase synthase synthetase

MQC87_RS16725: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

MQC87_RS16730: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

MQC87_RS16810: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

MQC87_RS16825: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

MQC87_RS16910: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001268.4	1.01	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0001249.5	0.81	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001132.4	0.72	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286.3	0.70	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.70	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.68	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002164.2	0.67	NRPS	peramine	Epichloe festucae
BGC0002171.2	0.67	NRPS, PKS	pyrophen, campyrone B	Aspergillus niger ATCC 1015
BGC0002275.2	0.67	NRPS, PKS	pyrophen, campyrone B	Aspergillus niger CBS 101883
BGC0001641.4	0.67	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000664.5	0.74	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001249.5	0.72	NRPS	dimethylcoprogen	Alternaria alternata
BGC0000649.3	0.70	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002164.2	0.69	NRPS	peramine	Epichloe festucae
BGC0001132.4	0.69	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286.3	0.68	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.68	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.67	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001456.3	0.67	terpene	isorenieratene	Streptomyces argillaceus
BGC0001641.4	0.66	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
tetraterpene	C40 carotenoid		C40	unknown	unknown

Genes with terpene domains:

MQC87_RS16910: PT_FPPS_like

Domain 1 (26 - 326): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

MQC87_RS16920: PT_phytoene_like

Domain 1 (16 - 313): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → PSPP; FPP → squalene; FPP → diapophytoene; GGPP → phytoene; PSPP → hydroxysqualene

MQC87_RS16935: Lycopene_cycl

Domain 1 (5 - 399): Lycopene cyclase

Reactions:: C40_carotenoid → C40_carotenoid

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.00 out of 20.97

Confidence: medium

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 23.51 out of 30.11

Confidence: medium

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.10 out of 26.85

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.64 out of 24.78

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16

Confidence: strong

Additional weak hits (20):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.92 out of 29.38

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 18.22 out of 29.25

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 20.75 out of 32.74

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 19.95 out of 27.55

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.26 out of 27.78

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 16.22 out of 28.14

Confidence: weak

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 23.11 out of 29.51

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.12 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 15.42 out of 28.14

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 20.26 out of 36.54

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 19.79 out of 30.97

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.94 out of 27.55

Confidence: weak

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 21.32 out of 27.18

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.94 out of 32.93

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.11 out of 32.93

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 13.76 out of 18.57

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 19.20 out of 26.12

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 17.82 out of 26.12

Confidence: weak

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 21.67 out of 29.72

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.65 out of 28.19

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Terpene

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 192577 - 271015:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal) + (X) + (Val)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 192577 - 245281:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 222944 - 266436:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (Val)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 228666 - 271015:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (Val)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

MQC87_RS16725: mal

PKS_AT (573..870): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; inactive: 70.8%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 92.7
inactive: 28.2
Methoxymalonyl-CoA: 28.2
Methylmalonyl-CoA: 24.2
CHC-CoA: 12.8
2-Methylbutyryl-CoA: 8.8
Isobutyryl-CoA: 7.6
fatty_acid: 6.0
Propionyl-CoA: 5.6
Ethylmalonyl-CoA: 1.8
trans-1,2-CPDA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

MQC87_RS16730: mxmal

PKS_AT (941..1182): mxmal

ATSignature: (unknown)

No matches above 50%

minowa: Methoxymalonyl-CoA

Prediction, score:

Methoxymalonyl-CoA: 36.6
Methylmalonyl-CoA: 30.3
Propionyl-CoA: 23.8
Malonyl-CoA: 21.6
2-Methylbutyryl-CoA: 20.1
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
Ethylmalonyl-CoA: -1.7
inactive: -3.9

MQC87_RS16810: X

AMP-binding (23..428): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LAAAFSAALEEPEIVVGGDINVYGPTEATATASY
Nearest Stachelhaus code(s):: Arg DAEDVGVIGK (47% 8Å match)
Stachelhaus code match:: 60% (weak)

MQC87_RS16825: Val

Search NORINE for peptide: strict or relaxed

AMP-binding (200..602): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: LDPAFDASTLEAWLVAGGDTNGYGPTENTTFTTC
Nearest Stachelhaus code(s):: Val DALWLGGTFK (91% 8Å match); bOH-Val DALWLGGTFK (79% 8Å match)
Stachelhaus code match:: 90% (moderate)

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CcpA	Catabolite control protein A
CelR	Cellobiose uptake repressor
LexA variant 2	Repressor of DNA damage response
RutR	Regulator of the pyrimidine and purine metabolism

NZ_JALDPQ010000062.1 - Region 1 - ectoine

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Location: 318,514 - 328,912 nt. (total: 10,399 nt) Show pHMM detection rules used

ectoine: ectoine_synt

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

MQC87_RS19290: NADH:flavin oxidoreductase/NADH oxidase

smcogs: SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

Transferases: aminotransferase

MQC87_RS19280: aminotransferase class V

smcogs: SMCOG1139: aminotransferase class V

MQC87_RS19310: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

MQC87_RS19320: aminotransferase class V

smcogs: SMCOG1139: aminotransferase class V

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000853.3	0.92	other (other)	ectoine	Streptomyces anulatus
BGC0002052.3	0.86	other (ectoine)	ectoine	Streptomyces sp.
BGC0000852.5	0.70	other (other)	ectoine	Sporosarcina pasteurii
BGC0000858.3	0.66	other (other)	ectoine	Methylobacter marinus
BGC0000859.3	0.66	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0000856.3	0.66	other (other)	ectoine	Methylophaga thalassica
BGC0000855.3	0.66	other (other)	ectoine	Methylomicrobium kenyense
BGC0000857.3	0.63	other (other)	ectoine	Methylophaga alcalica
BGC0000860.3	0.63	other (other)	ectoine	Methylarcula marina
BGC0000854.3	0.62	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000853.3	0.92	other (other)	ectoine	Streptomyces anulatus
BGC0002052.3	0.86	other (ectoine)	ectoine	Streptomyces sp.
BGC0000852.5	0.70	other (other)	ectoine	Sporosarcina pasteurii
BGC0000858.3	0.66	other (other)	ectoine	Methylobacter marinus
BGC0000859.3	0.66	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0000856.3	0.66	other (other)	ectoine	Methylophaga thalassica
BGC0000855.3	0.66	other (other)	ectoine	Methylomicrobium kenyense
BGC0000857.3	0.63	other (other)	ectoine	Methylophaga alcalica
BGC0000860.3	0.63	other (other)	ectoine	Methylarcula marina
BGC0000854.3	0.62	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.62 out of 19.52

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.81 out of 27.55

Confidence: medium

Additional weak hits (6):

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.51 out of 27.78

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 17.04 out of 26.12

Confidence: weak

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.03 out of 19.26

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.75 out of 21.55

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.67 out of 28.14

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.18 out of 28.19

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
GnfM	Regulator of nitrogen-fixation genes

NZ_JALDPQ010000063.1 - Region 1 - T3PKS

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Location: 78,261 - 119,391 nt. (total: 41,131 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

MQC87_RS20120: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

MQC87_RS20155: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

Transferases: kinase

MQC87_RS20195: PfkB domain protein

smcogs: SMCOG1276: PfkB domain protein

Hydrolases: protease

MQC87_RS20130: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Ligases: synthase

MQC87_RS20125: chalcone and stilbene synthase domain protein

smcogs: SMCOG1024: chalcone and stilbene synthase domain protein

MQC87_RS20200: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

MQC87_RS20205: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001310.5	0.83	PKS	naringenin	Streptomyces clavuligerus ATCC 27064
BGC0002127.3	0.71	PKS	flaviolin, 1,3,6,8-tetrahydroxynaphthalene	Streptomyces coelicolor A3(2)
BGC0000902.4	0.67	PKS	flaviolin	Saccharopolyspora erythraea NRRL 2338
BGC0000285.5	0.61	PKS, saccharide	flaviolin, flaviolin rhamnoside, 3,3'-diflaviolin	Saccharopolyspora erythraea
BGC0000280.5	0.53	PKS	2,4-diacetylphloroglucinol	Pseudomonas fluorescens
BGC0000281.3	0.52	PKS	2,4-diacetylphloroglucinol	Pseudomonas fluorescens
BGC0002711.2	0.51	PKS	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0002073.3	0.50	NRPS	dehydroxynocardamine	Corynebacterium propinquum
BGC0002476.2	0.48	NRPS	enterobactin	Escherichia coli str. K-12 substr. MG1655
BGC0001224.5	0.46	other (other)	reductasporine	uncultured bacterium

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001310.5	0.83	PKS	naringenin	Streptomyces clavuligerus ATCC 27064
BGC0002127.3	0.71	PKS	flaviolin, 1,3,6,8-tetrahydroxynaphthalene	Streptomyces coelicolor A3(2)
BGC0000902.4	0.67	PKS	flaviolin	Saccharopolyspora erythraea NRRL 2338
BGC0000285.5	0.61	PKS, saccharide	flaviolin, flaviolin rhamnoside, 3,3'-diflaviolin	Saccharopolyspora erythraea
BGC0000280.5	0.53	PKS	2,4-diacetylphloroglucinol	Pseudomonas fluorescens
BGC0000281.3	0.52	PKS	2,4-diacetylphloroglucinol	Pseudomonas fluorescens
BGC0002711.2	0.51	PKS	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0002073.3	0.50	NRPS	dehydroxynocardamine	Corynebacterium propinquum
BGC0002476.2	0.48	NRPS	enterobactin	Escherichia coli str. K-12 substr. MG1655
BGC0001224.5	0.46	other (other)	reductasporine	uncultured bacterium

Similar known clusters from MIBiG 4.0

Similar subclusters

Transcription Factor Binding Sites

Binding sites found:

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.46 out of 23.05

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.21 out of 27.78

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 28.03 out of 36.53

Confidence: medium

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 21.78 out of 29.72

Confidence: medium

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.62 out of 19.52

Confidence: medium

Additional weak hits (21):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.21 out of 30.22

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 17.38 out of 29.25

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 19.33 out of 30.97

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 18.99 out of 25.88

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 17.98 out of 31.73

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 14.78 out of 27.78

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.00 out of 27.55

Confidence: weak

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.73 out of 19.26

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.09 out of 28.14

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.16 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.82 out of 26.06

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.13 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.94 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.92 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.50 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.12 out of 26.06

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.31 out of 21.55

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.26 out of 28.19

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.33 out of 28.19

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 18.78 out of 35.63

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.76 out of 24.78

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
AfsR	Pleiotropic regulatory for antibiotic production
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
DmdR1	Iron(II)-dependent repressor
NtrC	Nitrogen regulatory protein C

NZ_JALDPQ010000063.1 - Region 2 - NRP-metallophore,NRPS

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Location: 146,261 - 245,499 nt. (total: 99,239 nt) Show pHMM detection rules used

NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

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other genes

resistance

TTA codons

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

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TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

MQC87_RS20430: lysine/ornithine N-monooxygenase

smcogs: SMCOG1080: lysine/ornithine N-monooxygenase

MQC87_RS20595: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Hydrolases: esterase hydrolase

MQC87_RS20470: enterobactin/ferric enterobactin esterase

smcogs: SMCOG1098: enterobactin/ferric enterobactin esterase

MQC87_RS20580: isochorismatase

smcogs: SMCOG1027: isochorismatase

MQC87_RS20605: enterobactin/ferric enterobactin esterase

smcogs: SMCOG1098: enterobactin/ferric enterobactin esterase

MQC87_RS20625: amidohydrolase

smcogs: SMCOG1244: amidohydrolase

Lyases: dehydratase

MQC87_RS20425: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Isomerases: isomerase

MQC87_RS20590: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: ligase synthase

MQC87_RS20410: polyprenol-monophosphomannose synthase ppm1

smcogs: SMCOG1123: polyprenol-monophosphomannose synthase ppm1

MQC87_RS20460: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

MQC87_RS20585: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

MQC87_RS20620: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000368.5	1.37	NRPS	griseobactin	Streptomyces sp. ATCC 700974
BGC0001128.4	1.02	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	1.01	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002286.3	1.00	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000325.5	0.97	NRPS	coelichelin	Streptomyces coelicolor A3(2)
BGC0001641.4	0.95	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001240.4	0.93	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0001166.5	0.92	NRPS	HC-toxin	Alternaria jesenskae
BGC0000307.4	0.90	NRPS	AbT1	Aureobasidium pullulans
BGC0000401.5	0.88	NRPS	paenibactin	Paenibacillus elgii B69

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000368.5	0.88	NRPS	griseobactin	Streptomyces sp. ATCC 700974
BGC0000401.5	0.72	NRPS	paenibactin	Paenibacillus elgii B69
BGC0001825.4	0.72	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0000325.5	0.71	NRPS	coelichelin	Streptomyces coelicolor A3(2)
BGC0000343.5	0.71	NRPS	enterobactin	Pseudomonas sp. J465
BGC0001132.4	0.71	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001185.5	0.71	NRPS	bacillibactin	Bacillus velezensis FZB42
BGC0001833.4	0.70	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.70	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.69	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16

Confidence: strong

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 19.35 out of 20.47

Confidence: strong

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.92 out of 20.47

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.25 out of 20.47

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 32.36 out of 36.53

Confidence: strong

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 27.19 out of 36.53

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 29.30 out of 36.53

Confidence: medium

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 21.94 out of 27.04

Confidence: medium

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 21.63 out of 27.04

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 28.57 out of 36.53

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 29.74 out of 36.53

Confidence: medium

Additional weak hits (36):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.67 out of 30.22

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 17.37 out of 28.14

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.25 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.99 out of 26.06

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.42 out of 21.55

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 12.96 out of 26.06

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.91 out of 39.62

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 19.07 out of 33.73

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 20.68 out of 32.74

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.96 out of 25.75

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.95 out of 30.25

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.80 out of 21.55

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.28 out of 21.55

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.38 out of 28.19

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.59 out of 22.40

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.59 out of 22.40

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 23.24 out of 36.53

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 18.09 out of 25.88

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.69 out of 36.53

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 15.77 out of 29.38

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.24 out of 32.93

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.75 out of 32.93

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 18.86 out of 35.63

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 23.54 out of 36.53

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 20.07 out of 30.98

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.87 out of 20.01

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 26.60 out of 39.62

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 25.40 out of 36.53

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 21.24 out of 36.53

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 25.71 out of 36.53

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.14 out of 32.93

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.26 out of 18.57

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 16.45 out of 29.25

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.73 out of 29.38

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.41 out of 25.75

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.29 out of 28.19

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 2, location 146260 - 245499:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Fo-OH-Orn - D-Thr - OH-Orn) + (Arg - Thr)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

MQC87_RS20460: Fo-OH-Orn - Thr - OH-Orn

Search NORINE for peptide: strict or relaxed

AMP-binding (144..542): Fo-OH-Orn

nrpys: Fo-OH-Orn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: Orn and hydroxy-Orn specific (Orn, OH-Orn)
Single AA prediction:: orn (Orn)

Stachelhaus prediction details:

Stachelhaus sequence:: RWQAFDISINELYLWCGGEYHGYGPAETTIGVSH
Nearest Stachelhaus code(s):: Fo-OH-Orn DINYWGGIGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1625..2036): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LNTHFDFAVWEGNQIFGGEVNMYGITETTVHVTH
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3061..3459): OH-Orn

nrpys: OH-Orn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: Orn and hydroxy-Orn specific (Orn, OH-Orn)
Single AA prediction:: orn (Orn)

Stachelhaus prediction details:

Stachelhaus sequence:: MNHVFDMSWEEWNVLLGGEYNLYGPTEYTINTLG
Nearest Stachelhaus code(s):: OH-Orn DMENLGLINK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

MQC87_RS20585: diOH-Bz

Search NORINE for peptide: strict or relaxed

AMP-binding (33..440): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: SGSLFPLSSPGGGLLVGGAQQVFGMAEGLVNYTR
Nearest Stachelhaus code(s):: diOH-Bz PLPGLGVVNK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

MQC87_RS20620: Arg - Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (477..917): Arg

nrpys: Arg

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LGHAFDASWDPWDVVVGGEVNLYGPTETTVDAYY
Nearest Stachelhaus code(s):: Arg DADDVGLVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1602..2010): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LATHFDFSVWEGNQVFGGEVNMYGITETTVHVSY
Nearest Stachelhaus code(s):: Thr DFWNVGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
DasR	N-acetylglucosamine dependent repressor
DmdR1	Iron(II)-dependent repressor
VqsM	Regulator of quorum-sensing signalling systems

NZ_JALDPQ010000063.1 - Region 3 - terpene

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Location: 306,135 - 328,348 nt. (total: 22,214 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase hydratase

MQC87_RS21005: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

MQC87_RS21030: Terpene synthase/cyclase metal-binding domain protein

smcogs: SMCOG1052: Terpene synthase/cyclase metal-binding domain protein

Ligases: ligase

MQC87_RS21000: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001181.4	0.83	terpene	geosmin	Streptomyces coelicolor A3(2)
BGC0001746.3	0.75	terpene	pristinol	Streptomyces pristinaespiralis ATCC 25486
BGC0001135.5	0.56	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001641.4	0.55	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.55	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001833.4	0.55	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002286.3	0.55	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.55	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.55	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000649.3	0.44	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001181.4	0.83	terpene	geosmin	Streptomyces coelicolor A3(2)
BGC0001746.3	0.75	terpene	pristinol	Streptomyces pristinaespiralis ATCC 25486
BGC0001135.5	0.56	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001641.4	0.55	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.55	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001833.4	0.55	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002286.3	0.55	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.55	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.55	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000649.3	0.44	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene		germacradienol	C15	C1-C10	OH
sesquiterpene		geosmin	C12	C1-C10	OH

Genes with terpene domains:

MQC87_RS21030: T1TS + T1TS

Domain 1 (2 - 326): Type 1 terpene synthase

Subtype: Geosmin synthase, N terminal domain

Reactions:: FPP → germacradienol

Domain 2 (336 - 697): Type 1 terpene synthase

Subtype: Geosmin synthase, C terminal domain

Reactions:: germacradienol → geosmin

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.02 out of 23.79

Confidence: medium

Additional weak hits (10):

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.75 out of 27.78

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 16.71 out of 31.73

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.75 out of 30.25

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.69 out of 27.78

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.26 out of 26.85

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.49 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.82 out of 29.38

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.79 out of 22.40

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 23.14 out of 29.65

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.37 out of 28.19

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate

TFBS definitions

Regulator	Description
IolR	Regulator of the inositol catabolism

NZ_JALDPQ010000063.1 - Region 4 - butyrolactone

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Location: 361,521 - 372,465 nt. (total: 10,945 nt) Show pHMM detection rules used

butyrolactone: AfsA

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

MQC87_RS21320: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

Transferases: methyltransferase

MQC87_RS21275: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

MQC87_RS21310: methyltransferase

smcogs: SMCOG1089: methyltransferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000848.5	0.85	other (other)	A-factor	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000849.4	0.83	other (butyrolactone)	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)
BGC0000850.5	0.69	other (other)	γ-butyrolactone	Streptomyces acidiscabies
BGC0002578.2	0.43	other (other)	gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F	Streptomyces venezuelae ATCC 10712
BGC0001633.3	0.41	other (other)	ketomemicin B3, ketomemicin B4	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0000393.5	0.38	NRPS, PKS	myxoprincomide-c506	Myxococcus xanthus DK 1622
BGC0000550.3	0.37	ribosomal	salivaricin G32	Streptococcus salivarius
BGC0000557.5	0.37	ribosomal	streptococcin A-FF22	Streptococcus pyogenes
BGC0000526.5	0.37	ribosomal	macedocin	Streptococcus macedonicus
BGC0000189.4	0.37	PKS	3-(2'-hydroxy-3'-oxo-4'-methylpentyl)-indole, 3-(2'-hydroxy-3'-oxo-4'-methylhexyl)-indole, 3-(2'-acetoxy-3'-oxo-4'-methylpentyl)-indole, 3-(2'-acetoxy-3'-oxo-4'-methylhexyl)-indole	Xenorhabdus bovienii SS-2004

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000848.5	0.85	other (other)	A-factor	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000849.4	0.83	other (butyrolactone)	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)
BGC0000850.5	0.69	other (other)	γ-butyrolactone	Streptomyces acidiscabies
BGC0002578.2	0.43	other (other)	gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F	Streptomyces venezuelae ATCC 10712
BGC0001633.3	0.41	other (other)	ketomemicin B3, ketomemicin B4	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0000393.5	0.38	NRPS, PKS	myxoprincomide-c506	Myxococcus xanthus DK 1622
BGC0000550.3	0.37	ribosomal	salivaricin G32	Streptococcus salivarius
BGC0000557.5	0.37	ribosomal	streptococcin A-FF22	Streptococcus pyogenes
BGC0000526.5	0.37	ribosomal	macedocin	Streptococcus macedonicus
BGC0000189.4	0.37	PKS	3-(2'-hydroxy-3'-oxo-4'-methylpentyl)-indole, 3-(2'-hydroxy-3'-oxo-4'-methylhexyl)-indole, 3-(2'-acetoxy-3'-oxo-4'-methylpentyl)-indole, 3-(2'-acetoxy-3'-oxo-4'-methylhexyl)-indole	Xenorhabdus bovienii SS-2004

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (3):

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 23.40 out of 36.53

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.15 out of 28.19

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.24 out of 29.65

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description

NZ_JALDPQ010000064.1 - Region 1 - terpene

Download region SVG

Location: 146,300 - 167,277 nt. (total: 20,978 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: deacetylase

MQC87_RS22345: polysaccharide deacetylase

smcogs: SMCOG1235: polysaccharide deacetylase

Lyases: cyclase hydratase

MQC87_RS22325: Terpene synthase/cyclase metal-binding domain protein

smcogs: SMCOG1052: Terpene synthase/cyclase metal-binding domain protein

MQC87_RS22355: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001866.4	0.29	PKS	viriditoxin	Byssochlamys spectabilis
BGC0000518.3	0.28	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0002553.2	0.27	other (other)	tunicamycin	Rathayibacter iranicus
BGC0000913.3	0.26	other (other)	MK-8	Enterobacter cloacae
BGC0000875.4	0.26	other (nucleoside), saccharide	caprazamycin, caprazamycin aglycon	Streptomyces sp. MK730-62F2
BGC0002034.3	0.25	other (other)	perquinoline A, perquinoline B, perquinoline C	Streptomyces sp. IB2014 016-6
BGC0000157.5	0.25	PKS	tautomycetin	Streptomyces sp. CK4412
BGC0001190.3	0.24	PKS	fusaric acid	Fusarium verticillioides 7600
BGC0000252.5	0.24	PKS	nonactin	Streptomyces griseus subsp. griseus
BGC0000243.4	0.24	PKS	nonactin, monactin, dinactin, trinactin, tetranactin	Streptomyces griseus subsp. griseus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001866.4	0.29	PKS	viriditoxin	Byssochlamys spectabilis
BGC0000518.3	0.28	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0002553.2	0.27	other (other)	tunicamycin	Rathayibacter iranicus
BGC0000913.3	0.26	other (other)	MK-8	Enterobacter cloacae
BGC0000875.4	0.26	other (nucleoside), saccharide	caprazamycin, caprazamycin aglycon	Streptomyces sp. MK730-62F2
BGC0002034.3	0.25	other (other)	perquinoline A, perquinoline B, perquinoline C	Streptomyces sp. IB2014 016-6
BGC0000157.5	0.25	PKS	tautomycetin	Streptomyces sp. CK4412
BGC0001190.3	0.24	PKS	fusaric acid	Fusarium verticillioides 7600
BGC0000252.5	0.24	PKS	nonactin	Streptomyces griseus subsp. griseus
BGC0000243.4	0.24	PKS	nonactin, monactin, dinactin, trinactin, tetranactin	Streptomyces griseus subsp. griseus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

No product predictions

Genes with terpene domains:

MQC87_RS22325: T1TS

Domain 1 (1 - 305): Type 1 terpene synthase

Subtype: unknown

Transcription Factor Binding Sites

Binding sites found:

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.11 out of 19.52

Confidence: medium

Additional weak hits (13):

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 19.99 out of 27.55

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 17.99 out of 26.33

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.07 out of 26.06

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.67 out of 26.33

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 12.61 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.01 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 12.65 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.75 out of 26.06

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.11 out of 27.78

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.47 out of 26.33

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 20.42 out of 33.73

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.83 out of 32.93

Confidence: weak

Terpene

TFBS Finder

Glossary

No acronyms to display

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production

NZ_JALDPQ010000064.1 - Region 2 - terpene-precursor

Download region SVG

Location: 383,678 - 404,721 nt. (total: 21,044 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: dehydratase

MQC87_RS23305: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthetase

MQC87_RS23340: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000673.3	0.53	terpene	pimara-8(14),15-diene	Aspergillus nidulans FGSC A4
BGC0000948.5	0.45	other (other)	α-galactosylceramide	Bacteroides fragilis NCTC 9343
BGC0000657.5	0.44	terpene	2-methylisoborneol	Pseudanabaena sp. dqh15
BGC0000677.5	0.41	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0000665.5	0.38	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0001485.4	0.36	other (other)	chuangxinmycin	Actinoplanes tsinanensis
BGC0002309.2	0.36	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0001910.4	0.35	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0000678.5	0.35	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000664.5	0.35	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000673.3	0.53	terpene	pimara-8(14),15-diene	Aspergillus nidulans FGSC A4
BGC0000948.5	0.45	other (other)	α-galactosylceramide	Bacteroides fragilis NCTC 9343
BGC0000657.5	0.44	terpene	2-methylisoborneol	Pseudanabaena sp. dqh15
BGC0000677.5	0.41	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0000665.5	0.38	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0001485.4	0.36	other (other)	chuangxinmycin	Actinoplanes tsinanensis
BGC0002309.2	0.36	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0001910.4	0.35	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0000678.5	0.35	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000664.5	0.35	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

MQC87_RS23340: PT_FPPS_like

Domain 1 (58 - 342): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.11 out of 23.79

Confidence: medium

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.86 out of 18.57

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.39 out of 19.26

Confidence: strong

Additional weak hits (4):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.03 out of 26.06

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.69 out of 20.97

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 19.43 out of 35.63

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 17.67 out of 24.78

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
IolR	Regulator of the inositol catabolism
ToxT	Regulator of MSHA biosynthesis

NZ_JALDPQ010000064.1 - Region 3 - lanthipeptide-class-iii

BGC0000553.3 (SSGG_RS09925):

Download region SVG

Location: 517,863 - 540,586 nt. (total: 22,724 nt) Show pHMM detection rules used

lanthipeptide-class-iii: (micKC and not PKS_KS)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: acetyltransferase aminotransferase

MQC87_RS23930: aminotransferase

smcogs: SMCOG1019: aminotransferase

MQC87_RS23985: Chloramphenicol acetyltransferase

smcogs: SMCOG1156: Chloramphenicol acetyltransferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000496.5	0.89	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000553.3	0.72	ribosomal	SRO15-2212	Streptomyces filamentosus NRRL 15998
BGC0000551.5	0.66	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000513.3	0.61	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000501.3	0.60	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000519.4	0.60	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000518.3	0.55	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0000546.3	0.54	ribosomal	SAL-2242	Streptomyces albidoflavus
BGC0001226.4	0.52	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0002700.2	0.51	ribosomal	bacinapeptin	Bacillus nakamurai

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000496.5	0.89	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000553.3	0.72	ribosomal	SRO15-2212	Streptomyces filamentosus NRRL 15998
BGC0000551.5	0.66	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000513.3	0.61	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000501.3	0.60	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000519.4	0.60	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000518.3	0.55	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0000546.3	0.54	ribosomal	SAL-2242	Streptomyces albidoflavus
BGC0001226.4	0.52	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0002700.2	0.51	ribosomal	bacinapeptin	Bacillus nakamurai

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for MQC87_RS23970

MQC87_RS23965

Leader:

MALLDLQAMDTPAEDSFGELAT

Core:

GSQVSLLVCEYSSLSVVLCTP

Core with dehydrations:

GDhaQVDhaLLVCysEYDhaDhaLDhaVVLCysDhbP

antiSMASH-DB 4.0 matches for MQC87_RS23965

100.0%

NC_010572.1and 60 others:

NC_021177.1 Lanthipeptides: SFUL_RS24355_lanthipeptideNZ_AQRK01000102.1 Lanthipeptides: YUW_RS30025_lanthipeptideNZ_ARPF01000003.1 Lanthipeptides: B083_RS0107255_lanthipeptideNZ_BMRY01000001.1 Lanthipeptides: IE140_RS02070_lanthipeptideNZ_BMSP01000003.1 Lanthipeptides: IE150_RS06495_lanthipeptideNZ_BMSZ01000003.1 Lanthipeptides: IE135_RS07550_lanthipeptideNZ_BMTW01000017.1 Lanthipeptides: IE134_RS28550_lanthipeptideNZ_BMUG01000009.1 Lanthipeptides: IE264_RS25430_lanthipeptideNZ_BMVK01000002.1 Lanthipeptides: IE272_RS07115_lanthipeptideNZ_BNBJ01000002.1 Lanthipeptides: IE304_RS05195_lanthipeptideNZ_CM003601.1 Lanthipeptides: JI76_RS25200_lanthipeptideNZ_CP010833.1 Lanthipeptides: TK78_RS10875_lanthipeptideNZ_CP011522.1 Lanthipeptides: ABE83_RS11805_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS23525_lanthipeptideNZ_CP015362.1 Lanthipeptides: A6E92_RS09975_lanthipeptideNZ_CP020563.1 Lanthipeptides: B7C62_RS24450_lanthipeptideNZ_CP020570.1 Lanthipeptides: B1H20_RS34690_lanthipeptideNZ_CP024957.1 Lanthipeptides: CVT27_RS22730_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS10225_lanthipeptideNZ_CP030930.1 Lanthipeptides: DTW94_RS22865_lanthipeptideNZ_CP061072.1 Lanthipeptides: HYC88_RS10560_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS24895_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS29435_lanthipeptideNZ_CP086102.1 Lanthipeptides: LK895_RS11660_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS24025_lanthipeptideNZ_CP096281.1 Lanthipeptides: MWG59_RS25685_lanthipeptideNZ_CP101397.1 Lanthipeptides: NLU04_RS06465_lanthipeptideNZ_CP110539.1 Lanthipeptides: OH133_RS12690_lanthipeptideNZ_CP112880.1 Lanthipeptides: N7925_RS11185_lanthipeptideNZ_CP113262.1 Lanthipeptides: OUQ49_RS22935_lanthipeptideNZ_CP117709.1 Lanthipeptides: PSQ21_RS24530_lanthipeptideNZ_DS999644.1 Lanthipeptides: SSGG_RS09925_lanthipeptideNZ_GL877172.1 Lanthipeptides: SACT1_RS12960_lanthipeptideNZ_JAAWWP010000002.1 Lanthipeptides: HFV08_RS04115_lanthipeptideNZ_JAGGOV010000004.1 Lanthipeptides: J7E92_RS02930_lanthipeptideNZ_JAHHWT010000009.1 Lanthipeptides: KM153_RS24430_lanthipeptideNZ_JALDPQ010000064.1 Lanthipeptides: MQC87_RS23965_lanthipeptideNZ_JAMFLF010000002.1 Lanthipeptides: M1212_RS07295_lanthipeptideNZ_JANRMN010000004.1 Lanthipeptides: NW249_RS08610_lanthipeptideNZ_JNLT01000003.1 Lanthipeptides: CD02_RS0108685_lanthipeptideNZ_KB890925.1 Lanthipeptides: B053_RS0113845_lanthipeptideNZ_KL573549.1 Lanthipeptides: BG84_RS0119125_lanthipeptideNZ_KQ257779.1 Lanthipeptides: IQ60_RS22540_lanthipeptideNZ_KZ195572.1 Lanthipeptides: B9W61_RS11940_lanthipeptideNZ_KZ679082.1 Lanthipeptides: C6W96_RS24050_lanthipeptideNZ_KZ819154.1 Lanthipeptides: DBP12_RS10285_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS23960_lanthipeptideNZ_KZ819182.1 Lanthipeptides: DBP21_RS24660_lanthipeptideNZ_LACR01000009.1 Lanthipeptides: YW5_RS12280_lanthipeptideNZ_LIPB01000001.1 Lanthipeptides: AMK17_RS03280_lanthipeptideNZ_LIPE01000001.1 Lanthipeptides: AMK12_RS03355_lanthipeptideNZ_LIVT01000001.1 Lanthipeptides: AMK24_RS01700_lanthipeptideNZ_LIVW01000001.1 Lanthipeptides: AMK28_RS03165_lanthipeptideNZ_LIXK01000001.1 Lanthipeptides: AMK23_RS04085_lanthipeptideNZ_LMEL01000012.1 Lanthipeptides: ASD29_RS10010_lanthipeptideNZ_LZRD01000054.1 Lanthipeptides: A3Q37_RS33745_lanthipeptideNZ_ML123117.1 Lanthipeptides: EES46_RS10300_lanthipeptideNZ_NNBN01000004.1 Lanthipeptides: CG717_RS12310_lanthipeptideNZ_VEHK01000004.1 Lanthipeptides: FS984_RS13530_lanthipeptideNZ_WWGD01000029.1 Lanthipeptides: GTY72_RS23245_lanthipeptide

Lanthipeptides: SGR_RS11800_lanthipeptide

1

GSQVSLLVCEYSSLSVVLCTP

21

GSQVSLLVCEYSSLSVVLCTP

1

GSQVSLLVCEYSSLSVVLCTP

21

95.2%

NZ_BDHJ01000008.1and 4 others:

NZ_CP032543.1 Lanthipeptides: D6270_RS22715_lanthipeptideNZ_CP076457.1 Lanthipeptides: KME66_RS09945_lanthipeptideNZ_CP077652.1 Lanthipeptides: KRR37_RS22855_lanthipeptideNZ_WUEJ01000001.1 Lanthipeptides: GRQ63_RS04560_lanthipeptide

Lanthipeptides: BHQ08_RS03045_lanthipeptide

1

GSQVSLLVCEYSSLSVVLCTP

21

GSQVSLLVCEYSSLSV LCTP

1

GSQVSLLVCEYSSLSVTLCTP

21

95.2%

NZ_CP010519.1and 1 other:

NZ_CP092644.1 Lanthipeptides: MID12_RS21330_lanthipeptide

Lanthipeptides: SLNWT_RS22370_lanthipeptide

1

GSQVSLLVCEYSSLSVVLCTP

21

GSQVSLLVCEYSSLSVVLC+P

1

GSQVSLLVCEYSSLSVVLCSP

21

with 77 more sequence matches

Only the first 10 are displayed here.

95.2%

NZ_CP045178.1:

Lanthipeptides: GBW32_RS28450_lanthipeptide

1

GSQVSLLVCEYSSLSVVLCTP

21

GSQVSLL+CEYSSLSVVLCTP

1

GSQVSLLICEYSSLSVVLCTP

21

95.2%

NZ_CP054926.1and 11 others:

NZ_CP068598.1 Lanthipeptides: IFE09_RS23820_lanthipeptideNZ_CP071044.1 Lanthipeptides: JHY03_RS23495_lanthipeptideNZ_CP080029.1 Lanthipeptides: KZO11_RS24935_lanthipeptideNZ_JAJUKK010000008.1 Lanthipeptides: LXH09_RS27635_lanthipeptideNZ_JOJC01000009.1 Lanthipeptides: IO23_RS0108435_lanthipeptideNZ_KB891296.1 Lanthipeptides: B061_RS0103425_lanthipeptideNZ_KZ268499.1 Lanthipeptides: CE422_RS23450_lanthipeptideNZ_KZ819159.1 Lanthipeptides: DBP19_RS22830_lanthipeptideNZ_LR881952.1 Lanthipeptides: STRPST75_RS10975_lanthipeptideNZ_LZQS01000001.1 Lanthipeptides: STIB_RS05225_lanthipeptideNZ_RCOL01000001.1 Lanthipeptides: STAN_RS24840_lanthipeptide

Lanthipeptides: HUT09_RS23550_lanthipeptide

1

GSQVSLLVCEYSSLSVVLCTP

21

GSQVSLLVCE+SSLSVVLCTP

1

GSQVSLLVCEFSSLSVVLCTP

21

95.2%

NZ_CP058556.1and 5 others:

NZ_CP059898.1 Lanthipeptides: H3V39_RS22935_lanthipeptideNZ_CP070242.1 Lanthipeptides: I6J39_RS23755_lanthipeptideNZ_CP070260.1 Lanthipeptides: I6J40_RS10935_lanthipeptideNZ_JAJDST010000047.1 Lanthipeptides: LJC81_RS16960_lanthipeptideNZ_WWGL01000003.1 Lanthipeptides: GTY38_RS03410_lanthipeptide

Lanthipeptides: HXS80_RS11105_lanthipeptide

1

GSQVSLLVCEYSSLSVVLCTP

21

GSQVS+LVCEYSSLSVVLCTP

1

GSQVSVLVCEYSSLSVVLCTP

21

90.5%

NZ_CM001165.1and 4 others:

NZ_CP021118.1 Lanthipeptides: CAC01_RS28155_lanthipeptideNZ_CP049945.1 Lanthipeptides: G9U55_RS17850_lanthipeptideNZ_CP119149.1 Lanthipeptides: P0D76_RS02270_lanthipeptideNZ_RWGV01000033.1 Lanthipeptides: EJA11_RS20985_lanthipeptide

Lanthipeptides: STTU_RS29395_lanthipeptide

1

GSQVSLLVCEYSSLSVVLCTP

21

GSQVSLL+CEYSSLSV LCTP

1

GSQVSLLICEYSSLSVTLCTP

21

85.7%

NC_020990.1and 26 others:

NZ_AMPN02000002.1 Lanthipeptides: SM8_RS12785_lanthipeptideNZ_AP025692.1 Lanthipeptides: MTP06_RS18190_lanthipeptideNZ_CM002273.1 Lanthipeptides: B590_RS12280_lanthipeptideNZ_CP009802.1 Lanthipeptides: SFR_RS12925_lanthipeptideNZ_CP014485.1 Lanthipeptides: Salbus254_RS12710_lanthipeptideNZ_CP016824.1 Lanthipeptides: BEN82_RS18165_lanthipeptideNZ_CP026490.1 Lanthipeptides: C3K23_RS19520_lanthipeptideNZ_CP031742.1 Lanthipeptides: D0C37_RS13445_lanthipeptideNZ_CP047147.1 Lanthipeptides: GR131_RS18520_lanthipeptideNZ_CP053539.1 Lanthipeptides: HN026_RS11800_lanthipeptideNZ_CP056773.1 Lanthipeptides: HWN34_RS12245_lanthipeptideNZ_CP063844.1 Lanthipeptides: IPZ55_RS12410_lanthipeptideNZ_CP064783.1 Lanthipeptides: IT782_RS12060_lanthipeptideNZ_CP076385.1 Lanthipeptides: KNZ81_RS12450_lanthipeptideNZ_CP079112.1 Lanthipeptides: STALF2_RS18135_lanthipeptideNZ_CP091820.1 Lanthipeptides: L2I08_RS02835_lanthipeptideNZ_CP106650.1 Lanthipeptides: B591_RS12385_lanthipeptideNZ_CP113103.1 Lanthipeptides: OSU72_RS17905_lanthipeptideNZ_JAHUVY010000001.1 Lanthipeptides: STALF3_RS17905_lanthipeptideNZ_JALLPQ010000001.1 Lanthipeptides: MWG58_RS12385_lanthipeptideNZ_KB890715.1 Lanthipeptides: B048_RS0115750_lanthipeptideNZ_KN549183.1 Lanthipeptides: D076_RS30740_lanthipeptideNZ_KZ195583.1 Lanthipeptides: B9W68_RS12440_lanthipeptideNZ_MNPQ01000004.1 Lanthipeptides: BGV78_RS11170_lanthipeptideNZ_OX371412.1 Lanthipeptides: OZE77_RS18215_lanthipeptideNZ_VOGX01000092.1 Lanthipeptides: FRZ02_RS31600_lanthipeptide

Lanthipeptides: XNR_RS11575_lanthipeptide

1

GSQVSLLVCEYSSLSVVLCTP

21

GSQ+SLL+CEYSSLSV LCTP

1

GSQISLLICEYSSLSVTLCTP

21

85.7%

NZ_AQRJ01000051.1and 1 other:

NZ_LFBV01000002.1 Lanthipeptides: AB852_RS09920_lanthipeptide

Lanthipeptides: YW7_RS14945_lanthipeptide

1

GSQVSLLVCEYSSLSVVLCTP

21

GSQVSL+VCEYSSLS +LCTP

1

GSQVSLIVCEYSSLSALLCTP

21

85.7%

NZ_CP045702.1:

Lanthipeptides: F0344_RS33200_lanthipeptide

1

GSQVSLLVCEYSSLSVVLCTP

21

GSQVSLLVCE+SSLS+ LCTP

1

GSQVSLLVCEHSSLSLTLCTP

21

85.7%

NZ_ML123034.1:

Lanthipeptides: EES43_RS19795_lanthipeptide

1

GSQVSLLVCEYSSLSVVLCTP

21

GSQVSLL+CE+SSLSV LCTP

1

GSQVSLLICEFSSLSVTLCTP

21

81.0%

NZ_LWLE01000019.1:

Lanthipeptides: A6A29_RS44250_lanthipeptide

1

GSQVSLLVCEYSSLSVVLCTP

21

GSQVSLL+CE+SSLS+ LCTP

1

GSQVSLLICEHSSLSLTLCTP

21

61.9%

NZ_QGGR01000008.1:

Lanthipeptides: BC793_RS19230_lanthipeptide

1

GSQVSLLVCEYSSLSVVLCT

20

GSQ SLL+C SSLSV C

2

GSQASLLLCGDSSLSVTTCN

21

MIBiG 4.0 matches for MQC87_RS23965

95.5%

Lanthipeptide: SRO15-2212

1

GSQVSLLVCEYSSLSVVLCTP

21

GSQVSLLVCEYSSLSVVLCTP

2

GSQVSLLVCEYSSLSVVLCTP

22

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 18.51 out of 25.31

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.11 out of 23.79

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.92 out of 20.47

Confidence: medium

Additional weak hits (10):

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.20 out of 21.55

Confidence: weak

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 17.99 out of 25.31

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.91 out of 20.01

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 19.59 out of 33.73

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.11 out of 25.75

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 15.78 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.19 out of 29.38

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.29 out of 32.93

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.12 out of 28.14

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.79 out of 22.40

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

MQC87_RS23965 - Class III

Cleavage pHMM score: 31.80

RODEO score: 0

Monoisotopic mass: 2075.1 Da

Molecular weight: 2076.4 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2094.4 Da N = 1; 2112.4 Da N = 2; 2130.5 Da N = 3; 2148.5 Da N = 4

TFBS definitions

Regulator	Description
CatR	H2O2-responsive repressor
IolR	Regulator of the inositol catabolism
VqsM	Regulator of quorum-sensing signalling systems

NZ_JALDPQ010000064.1 - Region 4 - NRPS-like,T1PKS

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Location: 604,093 - 658,864 nt. (total: 54,772 nt) Show pHMM detection rules used

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase reductase

MQC87_RS24365: dihydropteridine reductase

smcogs: SMCOG1159: dihydropteridine reductase

MQC87_RS24425: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

MQC87_RS24490: alkyl hydroperoxide reductase/ Thiol specific

smcogs: SMCOG1196: alkyl hydroperoxide reductase/ Thiol specific

Transferases: aminotransferase

MQC87_RS24410: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Hydrolases: dehalogenase esterase

MQC87_RS24325: haloalkane dehalogenase

smcogs: SMCOG1262: haloalkane dehalogenase

MQC87_RS24420: thioesterase

smcogs: SMCOG1004: thioesterase

Lyases: lyase

MQC87_RS24440: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Ligases: ligase synthase

MQC87_RS24405: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

MQC87_RS24430: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Translocases: permease

MQC87_RS24350: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001249.5	0.82	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001132.4	0.70	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286.3	0.69	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002164.2	0.69	NRPS	peramine	Epichloe festucae
BGC0001128.4	0.69	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001261.3	0.68	NRPS	AM-toxin	Alternaria alternata
BGC0001135.5	0.68	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001641.4	0.66	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001276.3	0.65	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.3	0.65	PKS	asperlactone	Aspergillus ochraceus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001249.5	0.73	NRPS	dimethylcoprogen	Alternaria alternata
BGC0001132.4	0.68	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002286.3	0.68	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002164.2	0.67	NRPS	peramine	Epichloe festucae
BGC0001128.4	0.67	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001261.3	0.67	NRPS	AM-toxin	Alternaria alternata
BGC0001135.5	0.67	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001641.4	0.66	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001276.3	0.66	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.3	0.66	PKS	asperlactone	Aspergillus ochraceus

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.89 out of 23.79

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 26.88 out of 36.53

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.91 out of 23.79

Confidence: medium

Additional weak hits (7):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.83 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.67 out of 26.06

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.25 out of 20.01

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.61 out of 29.38

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.36 out of 27.78

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 17.11 out of 31.73

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.92 out of 28.19

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 4, location 604092 - 658864:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal) + (aThr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 5, location 604092 - 647389:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal) + (aThr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 6, location 616206 - 658864:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal) + (aThr)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

MQC87_RS24405: mal

PKS_AT (554..851): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 131.5
inactive: 79.0
Methylmalonyl-CoA: 57.3
Methoxymalonyl-CoA: 56.7
Isobutyryl-CoA: 43.8
Ethylmalonyl-CoA: 38.7
CHC-CoA: 30.5
Propionyl-CoA: 28.6
Benzoyl-CoA: 23.5
fatty_acid: 21.8
Acetyl-CoA: 17.4
trans-1,2-CPDA: 14.9
2-Methylbutyryl-CoA: 14.9
3-Methylbutyryl-CoA: 11.8

MQC87_RS24430: aThr

Search NORINE for peptide: strict or relaxed

AMP-binding (302..687): aThr

nrpys: aThr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LAVHFDFSVWEGSQVLGGEVNMYGITETTVHVTA
Nearest Stachelhaus code(s):: aThr DFWSVGMVHK (94% 8Å match); Thr DFWSVGMVHK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

TFBS definitions

Regulator	Description
DmdR1	Iron(II)-dependent repressor
IolR	Regulator of the inositol catabolism

NZ_JALDPQ010000065.1 - Region 1 - lanthipeptide-class-ii,lanthipeptide-class-iii

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Location: 10,114 - 41,386 nt. (total: 31,273 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)
lanthipeptide-class-iii: (micKC and not PKS_KS)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

MQC87_RS27480: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

Hydrolases: protease

MQC87_RS27555: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase

MQC87_RS27495: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002700.2	0.38	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0000551.5	0.37	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000496.5	0.37	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000525.5	0.37	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000519.4	0.35	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000501.3	0.35	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000518.3	0.35	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0000553.3	0.34	ribosomal	SRO15-2212	Streptomyces filamentosus NRRL 15998
BGC0002111.3	0.34	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0000513.3	0.32	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002700.2	0.51	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0000551.5	0.50	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000496.5	0.50	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000525.5	0.50	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000519.4	0.49	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000501.3	0.49	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000518.3	0.49	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0000553.3	0.48	ribosomal	SRO15-2212	Streptomyces filamentosus NRRL 15998
BGC0002111.3	0.48	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0000513.3	0.47	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for MQC87_RS27495

MQC87_RS27525

Leader:

MSENTQPADDANETPEVEAHSVLDLQETSVQGG

MQC87_RS27525

Leader:

MSENTQPADDANETPEVEAHSVLDLQETSVQGG

Shared core:

DTTDGNCISVLSVVESQR

Core with dehydrations:

DDhbDhbDGNCysIDhaVLDhaVVEDhaQR

antiSMASH-DB 4.0 matches for MQC87_RS27525

100.0%

NZ_BNBJ01000007.1and 21 others:

NZ_BNBJ01000007.1 Lanthipeptides: IE304_RS13825_lanthipeptideNZ_BNBJ01000007.1 Lanthipeptides: IE304_RS13825_lanthipeptideNZ_BNBJ01000007.1 Lanthipeptides: IE304_RS13825_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptideNZ_DS999644.1 Lanthipeptides: SSGG_RS37575_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptideNZ_KL573557.1 Lanthipeptides: BG84_RS1000000140065_lanthipeptideNZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptideNZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptideNZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptideNZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptide

Lanthipeptides: IE304_RS13825_lanthipeptide

1

DTTDGNCISVLSVVESQR

18

DTTDGNCISVLSVVESQR

1

DTTDGNCISVLSVVESQR

18

94.4%

NZ_BMRY01000010.1and 58 others:

NZ_BMRY01000010.1 Lanthipeptides: IE140_RS27680_lanthipeptideNZ_BMRY01000010.1 Lanthipeptides: IE140_RS27680_lanthipeptideNZ_BMRY01000010.1 Lanthipeptides: IE140_RS27680_lanthipeptideNZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptideNZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptideNZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptideNZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptideNZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptideNZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptideNZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptideNZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptideNZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptideNZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptideNZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptideNZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptideNZ_KZ679082.1 Lanthipeptides: allorf_2505302_2505508_lanthipeptideNZ_KZ679082.1 Lanthipeptides: allorf_2505302_2505508_lanthipeptideNZ_KZ679082.1 Lanthipeptides: allorf_2505302_2505508_lanthipeptideNZ_KZ819154.1 Lanthipeptides: allorf_5241449_5241619_lanthipeptideNZ_KZ819154.1 Lanthipeptides: allorf_5241449_5241619_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptideNZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptideNZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptideNZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptideNZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptideNZ_NNBN01000010.1 Lanthipeptides: CG717_RS33255_lanthipeptideNZ_NNBN01000010.1 Lanthipeptides: CG717_RS33255_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptide

Lanthipeptides: IE140_RS27680_lanthipeptide

1

DTTDGNCISVLSVVESQR

18

DTTDGNCISVLSVVE QR

1

DTTDGNCISVLSVVEQQR

18

78.9%

Lanthipeptides: PSQ21_RS10520_lanthipeptide

1

DTTDGNCISVLSVVESQ

17

D TDGNCISVLSVVE+Q

1

DQTDGNCISVLSVVETQ

17

with 13 more sequence matches

Only the first 10 are displayed here.

77.8%

Lanthipeptides: A3Q37_RS37410_lanthipeptide

5

GNCISVLSVVESQR

18

GNCISVLSVVESQR

1

GNCISVLSVVESQR

14

61.1%

NZ_BNBJ01000007.1and 7 others:

NZ_CP079114.1 Lanthipeptides: KV381_RS11700_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18750_lanthipeptideNZ_KL573557.1 Lanthipeptides: BG84_RS1000000140060_lanthipeptide

Lanthipeptides: IE304_RS13830_lanthipeptide

5

GNCISVLSVVES

16

GNCISVLSVVE+

2

GNCISVLSVVEN

13

57.9%

Lanthipeptides: A3Q37_RS37415_lanthipeptide

2

TTDGNCISVLSVVES

16

GNCISVLSVVE+

5

APPGNCISVLSVVEN

19

50.0%

NZ_LMFT01000038.1and 1 other:

NZ_LMFT01000038.1 Lanthipeptides: ASD51_RS37395_lanthipeptide

Lanthipeptides: ASD51_RS37395_lanthipeptide

7

CISVLSVVE

15

CISVLSVVE

1

CISVLSVVE

9

44.4%

NZ_CP119145.1:

Lanthipeptides: PZB75_RS01650_lanthipeptide

7

CISVLSVVESQR

18

C+SV+SVV S+R

1

CVSVISVVLSER

12

37.5%

NZ_ML142907.1and 1 other:

NZ_ML142907.1 Lanthipeptides: DN53_RS02460_lanthipeptide

Lanthipeptides: DN53_RS02460_lanthipeptide

1

DTTDGNCISVLSVVES

16

DTT+G+C S S+V S

7

DTTNGDCTSGTSIVIS

22

23.5%

NC_021177.1and 9 others:

NC_021177.1 Lanthipeptides: SFUL_RS36595_lanthipeptideNZ_BMUG01000001.1 Lanthipeptides: IE264_RS01515_lanthipeptideNZ_BMUG01000001.1 Lanthipeptides: IE264_RS01515_lanthipeptideNZ_CP054926.1 Lanthipeptides: HUT09_RS11275_lanthipeptideNZ_CP054926.1 Lanthipeptides: HUT09_RS11275_lanthipeptideNZ_CP071044.1 Lanthipeptides: JHY03_RS11255_lanthipeptideNZ_CP071044.1 Lanthipeptides: JHY03_RS11255_lanthipeptideNZ_JOJC01000008.1 Lanthipeptides: IO23_RS1000000137100_lanthipeptideNZ_JOJC01000008.1 Lanthipeptides: IO23_RS1000000137100_lanthipeptide

Lanthipeptides: SFUL_RS36595_lanthipeptide

5

GNCISVLSVV

14

G+C+SVLSVV

22

GSCVSVLSVV

31

22.2%

Lanthipeptides: HW560_RS06640_lanthipeptide

3

TDGNCISVLSV

13

TDGNC+S ++

7

TDGNCVSTITA

17

20.0%

NZ_BDHJ01000009.1and 1 other:

NZ_CP076457.1 Lanthipeptides: KME66_RS23045_lanthipeptide

Lanthipeptides: BHQ08_RS34920_lanthipeptide

5

GNCISVLSVV

14

GNC+S +S+V

19

GNCVSTVSLV

28

19.2%

NZ_BMLN01000009.1:

Lanthipeptides: IEX28_RS15335_lanthipeptide

3

TDGNCISVLSV

13

TDGNC+ ++

7

TDGNCLKSITA

17

MQC87_RS27530

Leader:

MSENTKPAADDANETPEVEAHSVLDLQETAVHGDRDIIAP

MQC87_RS27530

Leader:

MSENTKPAADDANETPEVEAHSVLDLQETAVHGDRDIIAP

Shared core:

PGNCISVLSVVEN

Core with dehydrations:

PGNCysIDhaVLDhaVVEN

antiSMASH-DB 4.0 matches for MQC87_RS27530

100.0%

NZ_BNBJ01000007.1and 8 others:

NZ_CP079114.1 Lanthipeptides: KV381_RS11700_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18750_lanthipeptideNZ_KL573557.1 Lanthipeptides: BG84_RS1000000140060_lanthipeptideNZ_LZRD01000043.1 Lanthipeptides: A3Q37_RS37415_lanthipeptide

Lanthipeptides: IE304_RS13830_lanthipeptide

1

PGNCISVLSVVEN

13

PGNCISVLSVVEN

1

PGNCISVLSVVEN

13

69.2%

NZ_LMFT01000038.1and 1 other:

NZ_LMFT01000038.1 Lanthipeptides: ASD51_RS37395_lanthipeptide

Lanthipeptides: ASD51_RS37395_lanthipeptide

4

CISVLSVVEN

13

CISVLSVVE

1

CISVLSVVEG

10

61.1%

NZ_BMRY01000010.1and 58 others:

NZ_BMRY01000010.1 Lanthipeptides: IE140_RS27680_lanthipeptideNZ_BMRY01000010.1 Lanthipeptides: IE140_RS27680_lanthipeptideNZ_BMRY01000010.1 Lanthipeptides: IE140_RS27680_lanthipeptideNZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptideNZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptideNZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptideNZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptideNZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptideNZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptideNZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptideNZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptideNZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptideNZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptideNZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptideNZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptideNZ_KZ679082.1 Lanthipeptides: allorf_2505302_2505508_lanthipeptideNZ_KZ679082.1 Lanthipeptides: allorf_2505302_2505508_lanthipeptideNZ_KZ679082.1 Lanthipeptides: allorf_2505302_2505508_lanthipeptideNZ_KZ819154.1 Lanthipeptides: allorf_5241449_5241619_lanthipeptideNZ_KZ819154.1 Lanthipeptides: allorf_5241449_5241619_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptideNZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptideNZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptideNZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptideNZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptideNZ_NNBN01000010.1 Lanthipeptides: CG717_RS33255_lanthipeptideNZ_NNBN01000010.1 Lanthipeptides: CG717_RS33255_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptide

Lanthipeptides: IE140_RS27680_lanthipeptide

2

GNCISVLSVVEN

13

GNCISVLSVVE

5

GNCISVLSVVEQ

16

with 6 more sequence matches

61.1%

NZ_BNBJ01000007.1and 22 others:

NZ_BNBJ01000007.1 Lanthipeptides: IE304_RS13825_lanthipeptideNZ_BNBJ01000007.1 Lanthipeptides: IE304_RS13825_lanthipeptideNZ_BNBJ01000007.1 Lanthipeptides: IE304_RS13825_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptideNZ_DS999644.1 Lanthipeptides: SSGG_RS37575_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptideNZ_KL573557.1 Lanthipeptides: BG84_RS1000000140065_lanthipeptideNZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptideNZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptideNZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptideNZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptideNZ_LZRD01000043.1 Lanthipeptides: A3Q37_RS37410_lanthipeptide

Lanthipeptides: IE304_RS13825_lanthipeptide

2

GNCISVLSVVEN

13

GNCISVLSVVE+

5

GNCISVLSVVES

16

57.9%

Lanthipeptides: PSQ21_RS10520_lanthipeptide

2

GNCISVLSVVEN

13

GNCISVLSVVE

5

GNCISVLSVVET

16

26.5%

NC_021177.1and 9 others:

NC_021177.1 Lanthipeptides: SFUL_RS36595_lanthipeptideNZ_BMUG01000001.1 Lanthipeptides: IE264_RS01515_lanthipeptideNZ_BMUG01000001.1 Lanthipeptides: IE264_RS01515_lanthipeptideNZ_CP054926.1 Lanthipeptides: HUT09_RS11275_lanthipeptideNZ_CP054926.1 Lanthipeptides: HUT09_RS11275_lanthipeptideNZ_CP071044.1 Lanthipeptides: JHY03_RS11255_lanthipeptideNZ_CP071044.1 Lanthipeptides: JHY03_RS11255_lanthipeptideNZ_JOJC01000008.1 Lanthipeptides: IO23_RS1000000137100_lanthipeptideNZ_JOJC01000008.1 Lanthipeptides: IO23_RS1000000137100_lanthipeptide

Lanthipeptides: SFUL_RS36595_lanthipeptide

1

PGNCISVLSVV

11

PG+C+SVLSVV

21

PGSCVSVLSVV

31

23.3%

NZ_BDHJ01000009.1and 1 other:

NZ_CP076457.1 Lanthipeptides: KME66_RS23045_lanthipeptide

Lanthipeptides: BHQ08_RS34920_lanthipeptide

1

PGNCISVLSVV

11

PGNC+S +S+V

18

PGNCVSTVSLV

28

19.2%

NZ_NBBB01000022.1and 1 other:

NZ_NUOG01000083.1 Lanthipeptides: COE07_RS24905_lanthipeptide

Lanthipeptides: B6F67_RS25205_lanthipeptide

1

PGNCISVLSVVEN

13

PG C ++ + EN

7

PGTCQTLCRITEN

19

17.9%

NZ_OCTY01000002.1:

Lanthipeptides: allorf_0865928_0866053_lanthipeptide

1

PGNCISVLSVV

11

PG C+S +S +

10

PGKCVSHISYL

20

allorf_012354_012542

Leader:

MATSGHVDEDGM

Core:

RTAWHPIIGCHAHVMSKARARKGVKGPFGIDLCRRAPPARTRRSGENFHF

Core with dehydrations:

RDhbAWHPIIGCysHAHVMDhaKARARKGVKGPFGIDLCysRRAPPARDhbRRDhaGENFHF

antiSMASH-DB 4.0 matches for allorf_012354_012542

100.0%

NZ_JALDPQ010000065.1:

Lanthipeptides: allorf_012354_012542_lanthipeptide

1

RTAWHPIIGCHAHVMSKARARKGVKGPFGIDLCRRAPPARTRRSGENFHF

50

RTAWHPIIGCHAHVMSKARARKGVKGPFGIDLCRRAPPARTRRSGENFHF

1

RTAWHPIIGCHAHVMSKARARKGVKGPFGIDLCRRAPPARTRRSGENFHF

50

30.0%

NZ_CP013738.1:

Lanthipeptides: allorf_2654949_2655104_lanthipeptide

30

IDLCRRAPPARTRRSGENFHF

50

+DLCR PPART R ENFHF

1

LDLCRHPPPARTPRGVENFHF

21

28.0%

NZ_LIVT01000002.1:

Lanthipeptides: allorf_397934_398080_lanthipeptide

28

FGIDLCRRAPPARTRRSGENFH

49

FG+DLCRR+ P +T R G NFH

1

FGLDLCRRSSPGKTSRDGGNFH

22

with 5 more sequence matches

26.0%

NZ_LIVW01000002.1:

Lanthipeptides: allorf_0400297_0400458_lanthipeptide

30

IDLCRRAPPARTRRSGENFH

49

+DLCR PPA+TR++GE+FH

1

LDLCRHTPPAKTRQNGEDFH

20

20.0%

NZ_CP051884.1:

Lanthipeptides: allorf_3276552_3276758_lanthipeptide

19

RARKGVKGPFGIDLCRRAPPARTR

42

R GV GPFG+ CR ++R

2

RCVCGVVGPFGL-FCRATKELQSR

24

16.0%

NZ_CP063989.1:

Lanthipeptides: allorf_0194163_0194297_lanthipeptide

27

PFGIDLCRRAPPAR

40

P G L RR PP R

1

PIGSTLIRRLPPPR

14

16.0%

NZ_MUXN01000027.1:

Lanthipeptides: allorf_018463_018597_lanthipeptide

34

RRAPPARTRRSGEN

47

RRAP R+RR G++

2

RRAPAGRSRRCGDD

15

14.0%

NZ_FPCC01000026.1:

Lanthipeptides: allorf_25741_25842_lanthipeptide

26

GPFGIDLCRRAPPARTRRSG

45

P I+ C + R+RR+G

1

SPLAINRCMKQKTIRSRRAG

20

allorf_026695_026847

Leader:

MGNMGASGGFGRVRGRKMRAG

allorf_026695_026847

Leader:

MGNMGASGGFGRVRGRKMRAG

Shared core:

PRCAGAGPAAGSGRAYGPLRRPSPFPEAR

Core with dehydrations:

PRCysAGAGPAAGDhaGRAYGPLRRPDhaPFPEAR

antiSMASH-DB 4.0 matches for allorf_026695_026847

100.0%

NZ_JALDPQ010000065.1and 2 others:

NZ_JALDPQ010000065.1 Lanthipeptides: allorf_026695_026847_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: allorf_026695_026847_lanthipeptide

Lanthipeptides: allorf_026695_026847_lanthipeptide

1

PRCAGAGPAAGSGRAYGPLRRPSPFPEAR

29

PRCAGAGPAAGSGRAYGPLRRPSPFPEAR

1

PRCAGAGPAAGSGRAYGPLRRPSPFPEAR

29

30.6%

NZ_CP020570.1and 10 others:

NZ_CP020570.1 Lanthipeptides: allorf_2516141_2516284_lanthipeptideNZ_CP020570.1 Lanthipeptides: allorf_2516141_2516284_lanthipeptideNZ_CP058556.1 Lanthipeptides: allorf_5603706_5603849_lanthipeptideNZ_CP058556.1 Lanthipeptides: allorf_5603706_5603849_lanthipeptideNZ_CP058556.1 Lanthipeptides: allorf_5603706_5603849_lanthipeptideNZ_CP058556.1 Lanthipeptides: allorf_5603706_5603849_lanthipeptideNZ_CP059898.1 Lanthipeptides: allorf_2457020_2457163_lanthipeptideNZ_WWGL01000034.1 Lanthipeptides: allorf_1026403_1026546_lanthipeptideNZ_WWGL01000034.1 Lanthipeptides: allorf_1026403_1026546_lanthipeptideNZ_WWGL01000034.1 Lanthipeptides: allorf_1026403_1026546_lanthipeptide

Lanthipeptides: allorf_2516141_2516284_lanthipeptide

1

PRCAGAGPAAGSGRAYGPLRRP

22

PRCAG G GR G RP

19

PRCAGV----GCGRTIGTCVRP

36

30.6%

NZ_CP070242.1and 9 others:

NZ_CP070242.1 Lanthipeptides: allorf_2528027_2528170_lanthipeptideNZ_CP070242.1 Lanthipeptides: allorf_2528027_2528170_lanthipeptideNZ_CP070260.1 Lanthipeptides: allorf_5476524_5476667_lanthipeptideNZ_CP070260.1 Lanthipeptides: allorf_5476524_5476667_lanthipeptideNZ_CP070260.1 Lanthipeptides: allorf_5476524_5476667_lanthipeptideNZ_CP070260.1 Lanthipeptides: allorf_5476524_5476667_lanthipeptideNZ_JAJDST010000044.1 Lanthipeptides: allorf_029750_029893_lanthipeptideNZ_JAJDST010000044.1 Lanthipeptides: allorf_029750_029893_lanthipeptideNZ_JAJDST010000044.1 Lanthipeptides: allorf_029750_029893_lanthipeptide

Lanthipeptides: allorf_2528027_2528170_lanthipeptide

1

PRCAGAGPAAGSGRAYGPLRRP

22

PRCAG G GR G RP

19

PRCAGV----GCGRTIGMCVRP

36

with 4 more sequence matches

20.5%

NC_014098.1:

Lanthipeptides: allorf_2904135_2904323_lanthipeptide

8

PAAGSGRAYGPLRRPSPF

25

P GSG A G R PF

14

PTGGSGEAAGDCGRSEPF

31

18.6%

NZ_ML123085.1and 3 others:

NZ_ML123085.1 Lanthipeptides: allorf_0381774_0381971_lanthipeptideNZ_RDBM01000037.1 Lanthipeptides: allorf_1275501_1275698_lanthipeptideNZ_RDBM01000037.1 Lanthipeptides: allorf_1275501_1275698_lanthipeptide

Lanthipeptides: allorf_0381774_0381971_lanthipeptide

20

RRPSPFPEAR

29

RRPSP EAR

34

RRPSPGQEAR

43

18.2%

NC_021177.1and 6 others:

NZ_BMUG01000001.1 Lanthipeptides: allorf_0358025_0358183_lanthipeptideNZ_BMUG01000001.1 Lanthipeptides: allorf_0358025_0358183_lanthipeptideNZ_CP054926.1 Lanthipeptides: allorf_2551449_2551640_lanthipeptideNZ_CP071044.1 Lanthipeptides: allorf_2560866_2561024_lanthipeptideNZ_JOJC01000008.1 Lanthipeptides: allorf_032194_032352_lanthipeptideNZ_JOJC01000008.1 Lanthipeptides: allorf_032194_032352_lanthipeptide

Lanthipeptides: allorf_2607385_2607543_lanthipeptide

21

RPSPFPEAR

29

RPSP PEAR

36

RPSPLPEAR

44

15.2%

NZ_CP098485.1:

Lanthipeptides: allorf_6386562_6386786_lanthipeptide

7

GPAAGSGRAY-GPLRRPSPF

25

GPA G G AY G +RR +

18

GPAGGCGEAYRGTIRRNRTY

37

Lanthipeptide(s) for MQC87_RS27515

MQC87_RS27525

Leader:

MSENTQPADDANETPEVEAHSVLDLQETSVQGG

MQC87_RS27525

Leader:

MSENTQPADDANETPEVEAHSVLDLQETSVQGG

Shared core:

DTTDGNCISVLSVVESQR

Core with dehydrations:

DDhbDhbDGNCysIDhaVLDhaVVEDhaQR

antiSMASH-DB 4.0 matches for MQC87_RS27525

100.0%

NZ_BNBJ01000007.1and 21 others:

NZ_BNBJ01000007.1 Lanthipeptides: IE304_RS13825_lanthipeptideNZ_BNBJ01000007.1 Lanthipeptides: IE304_RS13825_lanthipeptideNZ_BNBJ01000007.1 Lanthipeptides: IE304_RS13825_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptideNZ_DS999644.1 Lanthipeptides: SSGG_RS37575_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptideNZ_KL573557.1 Lanthipeptides: BG84_RS1000000140065_lanthipeptideNZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptideNZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptideNZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptideNZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptide

Lanthipeptides: IE304_RS13825_lanthipeptide

1

DTTDGNCISVLSVVESQR

18

DTTDGNCISVLSVVESQR

1

DTTDGNCISVLSVVESQR

18

94.4%

NZ_BMRY01000010.1and 58 others:

NZ_BMRY01000010.1 Lanthipeptides: IE140_RS27680_lanthipeptideNZ_BMRY01000010.1 Lanthipeptides: IE140_RS27680_lanthipeptideNZ_BMRY01000010.1 Lanthipeptides: IE140_RS27680_lanthipeptideNZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptideNZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptideNZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptideNZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptideNZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptideNZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptideNZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptideNZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptideNZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptideNZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptideNZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptideNZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptideNZ_KZ679082.1 Lanthipeptides: allorf_2505302_2505508_lanthipeptideNZ_KZ679082.1 Lanthipeptides: allorf_2505302_2505508_lanthipeptideNZ_KZ679082.1 Lanthipeptides: allorf_2505302_2505508_lanthipeptideNZ_KZ819154.1 Lanthipeptides: allorf_5241449_5241619_lanthipeptideNZ_KZ819154.1 Lanthipeptides: allorf_5241449_5241619_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptideNZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptideNZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptideNZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptideNZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptideNZ_NNBN01000010.1 Lanthipeptides: CG717_RS33255_lanthipeptideNZ_NNBN01000010.1 Lanthipeptides: CG717_RS33255_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptide

Lanthipeptides: IE140_RS27680_lanthipeptide

1

DTTDGNCISVLSVVESQR

18

DTTDGNCISVLSVVE QR

1

DTTDGNCISVLSVVEQQR

18

78.9%

Lanthipeptides: PSQ21_RS10520_lanthipeptide

1

DTTDGNCISVLSVVESQ

17

D TDGNCISVLSVVE+Q

1

DQTDGNCISVLSVVETQ

17

with 13 more sequence matches

Only the first 10 are displayed here.

77.8%

Lanthipeptides: A3Q37_RS37410_lanthipeptide

5

GNCISVLSVVESQR

18

GNCISVLSVVESQR

1

GNCISVLSVVESQR

14

61.1%

NZ_BNBJ01000007.1and 7 others:

NZ_CP079114.1 Lanthipeptides: KV381_RS11700_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18750_lanthipeptideNZ_KL573557.1 Lanthipeptides: BG84_RS1000000140060_lanthipeptide

Lanthipeptides: IE304_RS13830_lanthipeptide

5

GNCISVLSVVES

16

GNCISVLSVVE+

2

GNCISVLSVVEN

13

57.9%

Lanthipeptides: A3Q37_RS37415_lanthipeptide

2

TTDGNCISVLSVVES

16

GNCISVLSVVE+

5

APPGNCISVLSVVEN

19

50.0%

NZ_LMFT01000038.1and 1 other:

NZ_LMFT01000038.1 Lanthipeptides: ASD51_RS37395_lanthipeptide

Lanthipeptides: ASD51_RS37395_lanthipeptide

7

CISVLSVVE

15

CISVLSVVE

1

CISVLSVVE

9

44.4%

NZ_CP119145.1:

Lanthipeptides: PZB75_RS01650_lanthipeptide

7

CISVLSVVESQR

18

C+SV+SVV S+R

1

CVSVISVVLSER

12

37.5%

NZ_ML142907.1and 1 other:

NZ_ML142907.1 Lanthipeptides: DN53_RS02460_lanthipeptide

Lanthipeptides: DN53_RS02460_lanthipeptide

1

DTTDGNCISVLSVVES

16

DTT+G+C S S+V S

7

DTTNGDCTSGTSIVIS

22

23.5%

NC_021177.1and 9 others:

NC_021177.1 Lanthipeptides: SFUL_RS36595_lanthipeptideNZ_BMUG01000001.1 Lanthipeptides: IE264_RS01515_lanthipeptideNZ_BMUG01000001.1 Lanthipeptides: IE264_RS01515_lanthipeptideNZ_CP054926.1 Lanthipeptides: HUT09_RS11275_lanthipeptideNZ_CP054926.1 Lanthipeptides: HUT09_RS11275_lanthipeptideNZ_CP071044.1 Lanthipeptides: JHY03_RS11255_lanthipeptideNZ_CP071044.1 Lanthipeptides: JHY03_RS11255_lanthipeptideNZ_JOJC01000008.1 Lanthipeptides: IO23_RS1000000137100_lanthipeptideNZ_JOJC01000008.1 Lanthipeptides: IO23_RS1000000137100_lanthipeptide

Lanthipeptides: SFUL_RS36595_lanthipeptide

5

GNCISVLSVV

14

G+C+SVLSVV

22

GSCVSVLSVV

31

22.2%

Lanthipeptides: HW560_RS06640_lanthipeptide

3

TDGNCISVLSV

13

TDGNC+S ++

7

TDGNCVSTITA

17

20.0%

NZ_BDHJ01000009.1and 1 other:

NZ_CP076457.1 Lanthipeptides: KME66_RS23045_lanthipeptide

Lanthipeptides: BHQ08_RS34920_lanthipeptide

5

GNCISVLSVV

14

GNC+S +S+V

19

GNCVSTVSLV

28

19.2%

NZ_BMLN01000009.1:

Lanthipeptides: IEX28_RS15335_lanthipeptide

3

TDGNCISVLSV

13

TDGNC+ ++

7

TDGNCLKSITA

17

MQC87_RS27530

Leader:

MSENTKPAADDANETPEVEAHSVLDLQETAVHGDRDIIAP

MQC87_RS27530

Leader:

MSENTKPAADDANETPEVEAHSVLDLQETAVHGDRDIIAP

Shared core:

PGNCISVLSVVEN

Core with dehydrations:

PGNCysIDhaVLDhaVVEN

antiSMASH-DB 4.0 matches for MQC87_RS27530

100.0%

NZ_BNBJ01000007.1and 8 others:

NZ_CP079114.1 Lanthipeptides: KV381_RS11700_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18750_lanthipeptideNZ_KL573557.1 Lanthipeptides: BG84_RS1000000140060_lanthipeptideNZ_LZRD01000043.1 Lanthipeptides: A3Q37_RS37415_lanthipeptide

Lanthipeptides: IE304_RS13830_lanthipeptide

1

PGNCISVLSVVEN

13

PGNCISVLSVVEN

1

PGNCISVLSVVEN

13

69.2%

NZ_LMFT01000038.1and 1 other:

NZ_LMFT01000038.1 Lanthipeptides: ASD51_RS37395_lanthipeptide

Lanthipeptides: ASD51_RS37395_lanthipeptide

4

CISVLSVVEN

13

CISVLSVVE

1

CISVLSVVEG

10

61.1%

NZ_BMRY01000010.1and 58 others:

NZ_BMRY01000010.1 Lanthipeptides: IE140_RS27680_lanthipeptideNZ_BMRY01000010.1 Lanthipeptides: IE140_RS27680_lanthipeptideNZ_BMRY01000010.1 Lanthipeptides: IE140_RS27680_lanthipeptideNZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptideNZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptideNZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptideNZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptideNZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptideNZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptideNZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptideNZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptideNZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptideNZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptideNZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptideNZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptideNZ_KZ679082.1 Lanthipeptides: allorf_2505302_2505508_lanthipeptideNZ_KZ679082.1 Lanthipeptides: allorf_2505302_2505508_lanthipeptideNZ_KZ679082.1 Lanthipeptides: allorf_2505302_2505508_lanthipeptideNZ_KZ819154.1 Lanthipeptides: allorf_5241449_5241619_lanthipeptideNZ_KZ819154.1 Lanthipeptides: allorf_5241449_5241619_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptideNZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptideNZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptideNZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptideNZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptideNZ_NNBN01000010.1 Lanthipeptides: CG717_RS33255_lanthipeptideNZ_NNBN01000010.1 Lanthipeptides: CG717_RS33255_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptide

Lanthipeptides: IE140_RS27680_lanthipeptide

2

GNCISVLSVVEN

13

GNCISVLSVVE

5

GNCISVLSVVEQ

16

with 6 more sequence matches

61.1%

NZ_BNBJ01000007.1and 22 others:

NZ_BNBJ01000007.1 Lanthipeptides: IE304_RS13825_lanthipeptideNZ_BNBJ01000007.1 Lanthipeptides: IE304_RS13825_lanthipeptideNZ_BNBJ01000007.1 Lanthipeptides: IE304_RS13825_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptideNZ_DS999644.1 Lanthipeptides: SSGG_RS37575_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptideNZ_KL573557.1 Lanthipeptides: BG84_RS1000000140065_lanthipeptideNZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptideNZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptideNZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptideNZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptideNZ_LZRD01000043.1 Lanthipeptides: A3Q37_RS37410_lanthipeptide

Lanthipeptides: IE304_RS13825_lanthipeptide

2

GNCISVLSVVEN

13

GNCISVLSVVE+

5

GNCISVLSVVES

16

57.9%

Lanthipeptides: PSQ21_RS10520_lanthipeptide

2

GNCISVLSVVEN

13

GNCISVLSVVE

5

GNCISVLSVVET

16

26.5%

NC_021177.1and 9 others:

NC_021177.1 Lanthipeptides: SFUL_RS36595_lanthipeptideNZ_BMUG01000001.1 Lanthipeptides: IE264_RS01515_lanthipeptideNZ_BMUG01000001.1 Lanthipeptides: IE264_RS01515_lanthipeptideNZ_CP054926.1 Lanthipeptides: HUT09_RS11275_lanthipeptideNZ_CP054926.1 Lanthipeptides: HUT09_RS11275_lanthipeptideNZ_CP071044.1 Lanthipeptides: JHY03_RS11255_lanthipeptideNZ_CP071044.1 Lanthipeptides: JHY03_RS11255_lanthipeptideNZ_JOJC01000008.1 Lanthipeptides: IO23_RS1000000137100_lanthipeptideNZ_JOJC01000008.1 Lanthipeptides: IO23_RS1000000137100_lanthipeptide

Lanthipeptides: SFUL_RS36595_lanthipeptide

1

PGNCISVLSVV

11

PG+C+SVLSVV

21

PGSCVSVLSVV

31

23.3%

NZ_BDHJ01000009.1and 1 other:

NZ_CP076457.1 Lanthipeptides: KME66_RS23045_lanthipeptide

Lanthipeptides: BHQ08_RS34920_lanthipeptide

1

PGNCISVLSVV

11

PGNC+S +S+V

18

PGNCVSTVSLV

28

19.2%

NZ_NBBB01000022.1and 1 other:

NZ_NUOG01000083.1 Lanthipeptides: COE07_RS24905_lanthipeptide

Lanthipeptides: B6F67_RS25205_lanthipeptide

1

PGNCISVLSVVEN

13

PG C ++ + EN

7

PGTCQTLCRITEN

19

17.9%

NZ_OCTY01000002.1:

Lanthipeptides: allorf_0865928_0866053_lanthipeptide

1

PGNCISVLSVV

11

PG C+S +S +

10

PGKCVSHISYL

20

allorf_026695_026847

Leader:

MGNMGASGGFGRVRGRKMRAG

allorf_026695_026847

Leader:

MGNMGASGGFGRVRGRKMRAG

Shared core:

PRCAGAGPAAGSGRAYGPLRRPSPFPEAR

Core with dehydrations:

PRCysAGAGPAAGDhaGRAYGPLRRPDhaPFPEAR

antiSMASH-DB 4.0 matches for allorf_026695_026847

100.0%

NZ_JALDPQ010000065.1and 2 others:

NZ_JALDPQ010000065.1 Lanthipeptides: allorf_026695_026847_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: allorf_026695_026847_lanthipeptide

Lanthipeptides: allorf_026695_026847_lanthipeptide

1

PRCAGAGPAAGSGRAYGPLRRPSPFPEAR

29

PRCAGAGPAAGSGRAYGPLRRPSPFPEAR

1

PRCAGAGPAAGSGRAYGPLRRPSPFPEAR

29

30.6%

NZ_CP020570.1and 10 others:

NZ_CP020570.1 Lanthipeptides: allorf_2516141_2516284_lanthipeptideNZ_CP020570.1 Lanthipeptides: allorf_2516141_2516284_lanthipeptideNZ_CP058556.1 Lanthipeptides: allorf_5603706_5603849_lanthipeptideNZ_CP058556.1 Lanthipeptides: allorf_5603706_5603849_lanthipeptideNZ_CP058556.1 Lanthipeptides: allorf_5603706_5603849_lanthipeptideNZ_CP058556.1 Lanthipeptides: allorf_5603706_5603849_lanthipeptideNZ_CP059898.1 Lanthipeptides: allorf_2457020_2457163_lanthipeptideNZ_WWGL01000034.1 Lanthipeptides: allorf_1026403_1026546_lanthipeptideNZ_WWGL01000034.1 Lanthipeptides: allorf_1026403_1026546_lanthipeptideNZ_WWGL01000034.1 Lanthipeptides: allorf_1026403_1026546_lanthipeptide

Lanthipeptides: allorf_2516141_2516284_lanthipeptide

1

PRCAGAGPAAGSGRAYGPLRRP

22

PRCAG G GR G RP

19

PRCAGV----GCGRTIGTCVRP

36

30.6%

NZ_CP070242.1and 9 others:

NZ_CP070242.1 Lanthipeptides: allorf_2528027_2528170_lanthipeptideNZ_CP070242.1 Lanthipeptides: allorf_2528027_2528170_lanthipeptideNZ_CP070260.1 Lanthipeptides: allorf_5476524_5476667_lanthipeptideNZ_CP070260.1 Lanthipeptides: allorf_5476524_5476667_lanthipeptideNZ_CP070260.1 Lanthipeptides: allorf_5476524_5476667_lanthipeptideNZ_CP070260.1 Lanthipeptides: allorf_5476524_5476667_lanthipeptideNZ_JAJDST010000044.1 Lanthipeptides: allorf_029750_029893_lanthipeptideNZ_JAJDST010000044.1 Lanthipeptides: allorf_029750_029893_lanthipeptideNZ_JAJDST010000044.1 Lanthipeptides: allorf_029750_029893_lanthipeptide

Lanthipeptides: allorf_2528027_2528170_lanthipeptide

1

PRCAGAGPAAGSGRAYGPLRRP

22

PRCAG G GR G RP

19

PRCAGV----GCGRTIGMCVRP

36

with 4 more sequence matches

20.5%

NC_014098.1:

Lanthipeptides: allorf_2904135_2904323_lanthipeptide

8

PAAGSGRAYGPLRRPSPF

25

P GSG A G R PF

14

PTGGSGEAAGDCGRSEPF

31

18.6%

NZ_ML123085.1and 3 others:

NZ_ML123085.1 Lanthipeptides: allorf_0381774_0381971_lanthipeptideNZ_RDBM01000037.1 Lanthipeptides: allorf_1275501_1275698_lanthipeptideNZ_RDBM01000037.1 Lanthipeptides: allorf_1275501_1275698_lanthipeptide

Lanthipeptides: allorf_0381774_0381971_lanthipeptide

20

RRPSPFPEAR

29

RRPSP EAR

34

RRPSPGQEAR

43

18.2%

NC_021177.1and 6 others:

NZ_BMUG01000001.1 Lanthipeptides: allorf_0358025_0358183_lanthipeptideNZ_BMUG01000001.1 Lanthipeptides: allorf_0358025_0358183_lanthipeptideNZ_CP054926.1 Lanthipeptides: allorf_2551449_2551640_lanthipeptideNZ_CP071044.1 Lanthipeptides: allorf_2560866_2561024_lanthipeptideNZ_JOJC01000008.1 Lanthipeptides: allorf_032194_032352_lanthipeptideNZ_JOJC01000008.1 Lanthipeptides: allorf_032194_032352_lanthipeptide

Lanthipeptides: allorf_2607385_2607543_lanthipeptide

21

RPSPFPEAR

29

RPSP PEAR

36

RPSPLPEAR

44

15.2%

NZ_CP098485.1:

Lanthipeptides: allorf_6386562_6386786_lanthipeptide

7

GPAAGSGRAY-GPLRRPSPF

25

GPA G G AY G +RR +

18

GPAGGCGEAYRGTIRRNRTY

37

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 22.32 out of 27.04

Confidence: medium

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 19.52 out of 19.52

Confidence: strong

Additional weak hits (9):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 12.81 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 15.85 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 12.48 out of 28.14

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 18.09 out of 31.73

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.28 out of 30.25

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.70 out of 21.55

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.10 out of 30.25

Confidence: weak

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.83 out of 20.97

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.80 out of 28.19

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

MQC87_RS27525 - Class II

Cleavage pHMM score: -4.20

RODEO score: 0

Monoisotopic mass: 1831.9 Da

Molecular weight: 1833.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1851.0 Da N = 1; 1869.0 Da N = 2; 1887.0 Da N = 3; 1905.0 Da N = 4

MQC87_RS27530 - Class II

Cleavage pHMM score: -7.30

RODEO score: 0

Monoisotopic mass: 1293.7 Da

Molecular weight: 1294.5 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1312.5 Da N = 1

allorf_012354_012542 - Class II

Cleavage pHMM score: -6.90

RODEO score: 0

Monoisotopic mass: 5576.0 Da

Molecular weight: 5579.5 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 5597.5 Da N = 1; 5615.5 Da N = 2

allorf_026695_026847 - Class II

Cleavage pHMM score: -6.50

RODEO score: 0

Monoisotopic mass: 2885.5 Da

Molecular weight: 2887.2 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2905.3 Da N = 1

MQC87_RS27525 - Class II

Cleavage pHMM score: -4.20

RODEO score: 0

Monoisotopic mass: 1831.9 Da

Molecular weight: 1833.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1851.0 Da N = 1; 1869.0 Da N = 2; 1887.0 Da N = 3; 1905.0 Da N = 4

MQC87_RS27530 - Class II

Cleavage pHMM score: -7.30

RODEO score: 0

Monoisotopic mass: 1293.7 Da

Molecular weight: 1294.5 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1312.5 Da N = 1

allorf_026695_026847 - Class II

Cleavage pHMM score: -6.50

RODEO score: 0

Monoisotopic mass: 2885.5 Da

Molecular weight: 2887.2 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2905.3 Da N = 1

MQC87_RS27525 - Class II

Cleavage pHMM score: -4.20

RODEO score: 0

Monoisotopic mass: 1831.9 Da

Molecular weight: 1833.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1851.0 Da N = 1; 1869.0 Da N = 2; 1887.0 Da N = 3; 1905.0 Da N = 4

MQC87_RS27530 - Class II

Cleavage pHMM score: -7.30

RODEO score: 0

Monoisotopic mass: 1293.7 Da

Molecular weight: 1294.5 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1312.5 Da N = 1

allorf_026695_026847 - Class II

Cleavage pHMM score: -6.50

RODEO score: 0

Monoisotopic mass: 2885.5 Da

Molecular weight: 2887.2 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2905.3 Da N = 1

MQC87_RS27525 - Class II

Cleavage pHMM score: -4.20

RODEO score: 0

Monoisotopic mass: 1831.9 Da

Molecular weight: 1833.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1851.0 Da N = 1; 1869.0 Da N = 2; 1887.0 Da N = 3; 1905.0 Da N = 4

MQC87_RS27530 - Class II

Cleavage pHMM score: -7.30

RODEO score: 0

Monoisotopic mass: 1293.7 Da

Molecular weight: 1294.5 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1312.5 Da N = 1

allorf_026695_026847 - Class II

Cleavage pHMM score: -6.50

RODEO score: 0

Monoisotopic mass: 2885.5 Da

Molecular weight: 2887.2 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2905.3 Da N = 1

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
DasR	N-acetylglucosamine dependent repressor

NZ_JALDPQ010000065.1 - Region 2 - NI-siderophore

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Location: 85,276 - 115,054 nt. (total: 29,779 nt) Show pHMM detection rules used

NI-siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

MQC87_RS27765: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

MQC87_RS27805: lysine/ornithine N-monooxygenase

smcogs: SMCOG1080: lysine/ornithine N-monooxygenase

Hydrolases: hydrolase

MQC87_RS27830: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Lyases: decarboxylase

MQC87_RS27800: Decarboxylase, pyridoxal-dependent

smcogs: SMCOG1180: Decarboxylase, pyridoxal-dependent

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000941.3	0.88	other (other)	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001478.5	0.83	other (other)	desferrioxamine E	Streptomyces sp. ID38640
BGC0002305.2	0.78	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0000940.5	0.71	other (other)	desferrioxamin B, desferrioxamine E	Streptomyces coelicolor A3(2)
BGC0001453.5	0.71	other (other)	desferrioxamine	Streptomyces argillaceus
BGC0001572.3	0.70	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0002464.3	0.62	other (other)	alcaligin	Bordetella pertussis Tohama I
BGC0002690.2	0.59	other (other)	FW0622	Verrucosispora sp. FIM060022
BGC0002620.2	0.55	other (other)	fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4	Fulvivirga marina
BGC0002469.2	0.54	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000941.3	0.88	other (other)	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001478.5	0.83	other (other)	desferrioxamine E	Streptomyces sp. ID38640
BGC0002305.2	0.78	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0000940.5	0.71	other (other)	desferrioxamin B, desferrioxamine E	Streptomyces coelicolor A3(2)
BGC0001453.5	0.71	other (other)	desferrioxamine	Streptomyces argillaceus
BGC0001572.3	0.70	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0002464.3	0.62	other (other)	alcaligin	Bordetella pertussis Tohama I
BGC0002690.2	0.59	other (other)	FW0622	Verrucosispora sp. FIM060022
BGC0002620.2	0.55	other (other)	fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4	Fulvivirga marina
BGC0002469.2	0.54	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.52 out of 19.26

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 36.53 out of 36.53

Confidence: strong

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 27.77 out of 36.53

Confidence: medium

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 28.15 out of 30.11

Confidence: strong

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 28.15 out of 30.11

Confidence: strong

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 18.36 out of 25.31

Confidence: medium

Additional weak hits (11):

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.52 out of 20.97

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.65 out of 28.19

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.86 out of 19.52

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 18.25 out of 36.54

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 18.29 out of 36.54

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.62 out of 23.43

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.84 out of 26.85

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.28 out of 30.25

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 21.83 out of 30.11

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 30.11

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 22.58 out of 30.11

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
CatR	H2O2-responsive repressor
CelR	Cellobiose uptake repressor
DmdR1	Iron(II)-dependent repressor

NZ_JALDPQ010000066.1 - Region 1 - RRE-containing,azole-containing-RiPP

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Location: 151,935 - 186,770 nt. (total: 34,836 nt) Show pHMM detection rules used

azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Azole RiPPs

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: hydrolase

MQC87_RS31100: amidohydrolase

smcogs: SMCOG1244: amidohydrolase

Lyases: dehydratase

MQC87_RS31135: Lantibiotic dehydratase domain protein

smcogs: SMCOG1155: Lantibiotic dehydratase domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001146.5	0.37	ribosomal	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0000603.5	0.36	ribosomal	cyclothiazomycin	Streptomyces hygroscopicus
BGC0001145.5	0.34	ribosomal	cyclothiazomycin b1	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0001472.5	0.33	ribosomal	berninamycin A	Streptomyces bernensis
BGC0001640.3	0.33	ribosomal	kocurin	Kocuria rosea
BGC0000607.5	0.32	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0000569.5	0.31	ribosomal	plantazolicin	Bacillus velezensis FZB42
BGC0002316.2	0.30	ribosomal	cebulantin	Saccharopolyspora cebuensis
BGC0001860.4	0.30	ribosomal	thiomuracin	Thermobispora bispora DSM 43833
BGC0000566.5	0.29	ribosomal	streptolysin S	Streptococcus pyogenes M1 GAS

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000603.5	0.51	ribosomal	cyclothiazomycin	Streptomyces hygroscopicus
BGC0001146.5	0.51	ribosomal	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0001860.4	0.50	ribosomal	thiomuracin	Thermobispora bispora DSM 43833
BGC0001145.5	0.49	ribosomal	cyclothiazomycin b1	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0001640.3	0.49	ribosomal	kocurin	Kocuria rosea
BGC0001472.5	0.48	ribosomal	berninamycin A	Streptomyces bernensis
BGC0000607.5	0.47	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0001174.4	0.47	ribosomal	corynazolicin	Corynebacterium urealyticum DSM 7111
BGC0000569.5	0.47	ribosomal	plantazolicin	Bacillus velezensis FZB42
BGC0000613.5	0.47	ribosomal	thiomuracin A	Nonomuraea sp. Bp3714-39

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.68 out of 20.47

Confidence: medium

Additional weak hits (2):

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.07 out of 39.62

Confidence: weak

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 21.53 out of 32.38

Confidence: weak

(Thi)azol(in)e containing peptide predictions

No core peptides found.

RREFinder

TFBS Finder

Azole RiPPs

RRE predictions

: RRE type: Thiopeptide_F_RRE; Location: 39 - 118; Score: 62.9; RRE type: Heterocycloanthracin_C_RRE; Location: 39 - 125; Score: 41.8
: RRE type: Thiopeptide_F_RRE; Location: 39 - 118; Score: 62.9; RRE type: Heterocycloanthracin_C_RRE; Location: 39 - 125; Score: 41.8

TFBS definitions

Regulator	Description
VqsM	Regulator of quorum-sensing signalling systems

Core peptide predictions

No core peptides found.

NZ_JALDPQ010000067.1 - Region 1 - NI-siderophore

Download region SVG

Location: 57,147 - 89,906 nt. (total: 32,760 nt) Show pHMM detection rules used

NI-siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase

MQC87_RS32915: Antibiotic biosynthesis monooxygenase

smcogs: SMCOG1258: Antibiotic biosynthesis monooxygenase

Transferases: aminotransferase

MQC87_RS32870: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Isomerases: mutase

MQC87_RS32920: phosphoglycerate mutase

smcogs: SMCOG1101: phosphoglycerate mutase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002692.2	0.55	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0000942.4	0.55	other (other)	petrobactin	Bacillus anthracis str. Ames
BGC0001713.5	0.52	other (other)	ochrobactin	Ochrobactrum anthropi
BGC0002683.2	0.51	NRPS	schizokinen	Nostoc sp. PCC 7120 = FACHB-418
BGC0000295.5	0.51	NRPS	acinetoferrin	Acinetobacter haemolyticus
BGC0002469.2	0.51	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0001531.5	0.50	other (other)	bisucaberin B	Tenacibaculum mesophilum
BGC0000939.5	0.50	other (other)	aerobactin	Grimontia hollisae
BGC0001572.3	0.50	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0002470.2	0.49	other (other)	synechobactin C9, synechobactin C11, synechobactin 13, synechobactin 14, synechobactin 16, synechobactin A, synechobactin B, synechobactin C	Synechococcus sp. PCC 7002

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002692.2	0.55	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0000942.4	0.55	other (other)	petrobactin	Bacillus anthracis str. Ames
BGC0001713.5	0.52	other (other)	ochrobactin	Ochrobactrum anthropi
BGC0002683.2	0.51	NRPS	schizokinen	Nostoc sp. PCC 7120 = FACHB-418
BGC0000295.5	0.51	NRPS	acinetoferrin	Acinetobacter haemolyticus
BGC0002469.2	0.51	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0001531.5	0.50	other (other)	bisucaberin B	Tenacibaculum mesophilum
BGC0000939.5	0.50	other (other)	aerobactin	Grimontia hollisae
BGC0001572.3	0.50	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0002470.2	0.49	other (other)	synechobactin C9, synechobactin C11, synechobactin 13, synechobactin 14, synechobactin 16, synechobactin A, synechobactin B, synechobactin C	Synechococcus sp. PCC 7002

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.26 out of 19.26

Confidence: medium

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 25.36 out of 30.22

Confidence: medium

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 21.90 out of 27.04

Confidence: medium

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 25.84 out of 30.12

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.92 out of 20.47

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.93 out of 24.78

Confidence: medium

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 24.17 out of 27.18

Confidence: medium

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 22.03 out of 27.18

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.18 out of 20.47

Confidence: medium

Additional weak hits (14):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 18.19 out of 31.73

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.66 out of 27.78

Confidence: weak

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 23.40 out of 29.51

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.39 out of 30.25

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.25 out of 30.25

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.04 out of 29.65

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.62 out of 29.65

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.88 out of 29.65

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 23.09 out of 29.65

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 19.77 out of 25.88

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.65 out of 28.19

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.59 out of 22.40

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.79 out of 29.65

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 17.88 out of 24.78

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
ClgR	Caseinolytic protease gene regulator
DasR	N-acetylglucosamine dependent repressor
LexA variant 2	Repressor of DNA damage response
NrdR	Represses ribonucleotide reductase encoding genes
OsdR	Development and stress management regulator
VqsM	Regulator of quorum-sensing signalling systems

NZ_JALDPQ010000067.1 - Region 2 - hydrogen-cyanide

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Location: 193,816 - 206,725 nt. (total: 12,910 nt) Show pHMM detection rules used

hydrogen-cyanide: (Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD) and DAO)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase reductase

MQC87_RS33420: FAD dependent oxidoreductase

smcogs: SMCOG1103: FAD dependent oxidoreductase

MQC87_RS33430: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

Hydrolases: deaminase

MQC87_RS33450: ornithine cyclodeaminase

smcogs: SMCOG1158: ornithine cyclodeaminase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002345.2	0.54	other (other)	hydrogen cyanide	Pseudomonas fluorescens
BGC0002285.2	0.29	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0000595.3	0.25	ribosomal	SCO-2138	Streptomyces coelicolor A3(2)
BGC0000135.5	0.21	PKS	reveromycin A	Streptomyces sp. SN-593

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002345.2	0.54	other (other)	hydrogen cyanide	Pseudomonas fluorescens
BGC0002285.2	0.29	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0000595.3	0.25	ribosomal	SCO-2138	Streptomyces coelicolor A3(2)
BGC0000135.5	0.21	PKS	reveromycin A	Streptomyces sp. SN-593

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 22.40 out of 22.40

Confidence: strong

Additional weak hits (6):

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.87 out of 20.01

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.13 out of 25.75

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.93 out of 39.62

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.49 out of 29.65

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 16.35 out of 33.14

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 20.42 out of 22.40

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
HypR	L-hydroxyproline utilization repressor

NZ_JALDPQ010000067.1 - Region 3 - RiPP-like

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Location: 338,337 - 349,728 nt. (total: 11,392 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002387.2	0.27	PKS	yangpumicin A	Micromonospora yangpuensis
BGC0002788.2	0.25	PKS	14-hydroxyisochainin	Streptomyces peucetius subsp. caesius ATCC 27952
BGC0001377.5	0.24	PKS	uncialamycin	Streptomyces uncialis
BGC0001060.5	0.22	PKS	dynemicin A	Micromonospora chersina
BGC0001984.3	0.20	NRPS	sarpeptin A, sarpeptin B	Streptomyces sp.
BGC0000241.5	0.19	PKS, saccharide	lomaiviticin A, lomaiviticin C, lomaiviticin D, lomaiviticin E	Salinispora tropica CNB-440
BGC0001693.3	0.18	PKS	nenestatin	Micromonospora echinospora

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002387.2	0.27	PKS	yangpumicin A	Micromonospora yangpuensis
BGC0002788.2	0.25	PKS	14-hydroxyisochainin	Streptomyces peucetius subsp. caesius ATCC 27952
BGC0001377.5	0.24	PKS	uncialamycin	Streptomyces uncialis
BGC0001060.5	0.22	PKS	dynemicin A	Micromonospora chersina
BGC0001984.3	0.20	NRPS	sarpeptin A, sarpeptin B	Streptomyces sp.
BGC0000241.5	0.19	PKS, saccharide	lomaiviticin A, lomaiviticin C, lomaiviticin D, lomaiviticin E	Salinispora tropica CNB-440
BGC0001693.3	0.18	PKS	nenestatin	Micromonospora echinospora

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.80 out of 20.47

Confidence: medium

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.22 out of 26.85

Confidence: medium

Additional weak hits (2):

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.40 out of 29.65

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 19.18 out of 27.04

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
RutR	Regulator of the pyrimidine and purine metabolism
VqsM	Regulator of quorum-sensing signalling systems

NZ_JALDPQ010000067.1 - Region 4 - ectoine

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Location: 748,613 - 758,987 nt. (total: 10,375 nt) Show pHMM detection rules used

ectoine: ectoine_synt

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

MQC87_RS35870: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Ligases: ligase

MQC87_RS35845: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000342.4	0.59	NRPS	enniatin	Fusarium equiseti
BGC0000307.4	0.59	NRPS	AbT1	Aureobasidium pullulans
BGC0001641.4	0.59	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001778.5	0.48	other (other)	showdomycin	Streptomyces showdoensis
BGC0002020.3	0.44	NRPS, saccharide	photolose, oligosaccharide 1 (GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 2 (GlcNAc-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 3 (GlcNAc-β(1-4)-GlcNAc-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 4 (GlcN-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 5 (6-phosphoGlcN-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc)	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000131.5	0.43	PKS	pyrrolomycin	Streptomyces sp. UC 11065
BGC0002097.3	0.41	NRPS, PKS, saccharide	kosinostatin	Micromonospora sp. 28ISP2-46
BGC0001073.5	0.40	NRPS, PKS	kosinostatin	Micromonospora sp. TP-A0468
BGC0002555.3	0.40	NRPS, PKS	emerimicin V, emerimicin VI, emerimicin VII, emerimicin VIII, emerimicin IX, emerimicin X	Acremonium sp.
BGC0000312.4	0.40	NRPS	bassianolide	Beauveria bassiana

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000342.4	0.59	NRPS	enniatin	Fusarium equiseti
BGC0000307.4	0.59	NRPS	AbT1	Aureobasidium pullulans
BGC0001641.4	0.59	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001778.5	0.48	other (other)	showdomycin	Streptomyces showdoensis
BGC0002020.3	0.44	NRPS, saccharide	photolose, oligosaccharide 1 (GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 2 (GlcNAc-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 3 (GlcNAc-β(1-4)-GlcNAc-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 4 (GlcN-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 5 (6-phosphoGlcN-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc)	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000131.5	0.43	PKS	pyrrolomycin	Streptomyces sp. UC 11065
BGC0002097.3	0.41	NRPS, PKS, saccharide	kosinostatin	Micromonospora sp. 28ISP2-46
BGC0001073.5	0.40	NRPS, PKS	kosinostatin	Micromonospora sp. TP-A0468
BGC0002555.3	0.40	NRPS, PKS	emerimicin V, emerimicin VI, emerimicin VII, emerimicin VIII, emerimicin IX, emerimicin X	Acremonium sp.
BGC0000312.4	0.40	NRPS	bassianolide	Beauveria bassiana

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 26.07 out of 30.12

Confidence: medium

Additional weak hits (3):

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.42 out of 29.65

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.27 out of 32.93

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.59 out of 29.65

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
OsdR	Development and stress management regulator

NZ_JALDPQ010000068.1 - Region 1 - NRPS,NRPS-like,PKS-like,betalactone

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Location: 120,783 - 189,630 nt. (total: 68,848 nt) Show pHMM detection rules used

PKS-like: (t2pks2 or ksIII)
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
betalactone: (HMGL-like and AMP-binding)
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase

MQC87_RS36685: dioxygenase, TauD/TfdA

smcogs: SMCOG1121: dioxygenase, TauD/TfdA

MQC87_RS36770: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

MQC87_RS36790: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Transferases: PPTase

MQC87_RS36815: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1060: 4'-phosphopantetheinyl transferase

Hydrolases: esterase

MQC87_RS36765: thioesterase

smcogs: SMCOG1004: thioesterase

MQC87_RS36780: thioesterase

smcogs: SMCOG1004: thioesterase

MQC87_RS36800: thioesterase

smcogs: SMCOG1004: thioesterase

Ligases: ligase synthase

MQC87_RS36635: carbamoyl phosphate synthase small subunit

smcogs: SMCOG1249: carbamoyl phosphate synthase small subunit

MQC87_RS36680: 8-amino-7-oxononanoate synthase

smcogs: SMCOG1109: 8-amino-7-oxononanoate synthase

MQC87_RS36690: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

MQC87_RS36745: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

MQC87_RS36775: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

MQC87_RS36805: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000342.4	1.06	NRPS	enniatin	Fusarium equiseti
BGC0001132.4	1.05	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	1.04	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	1.04	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	1.02	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001641.4	1.00	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002164.2	1.00	NRPS	peramine	Epichloe festucae
BGC0000307.4	0.98	NRPS	AbT1	Aureobasidium pullulans
BGC0001758.4	0.96	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002075.3	0.95	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000342.4	0.68	NRPS	enniatin	Fusarium equiseti
BGC0001132.4	0.68	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.68	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.68	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.67	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001641.4	0.67	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002164.2	0.67	NRPS	peramine	Epichloe festucae
BGC0000307.4	0.66	NRPS	AbT1	Aureobasidium pullulans
BGC0001758.4	0.65	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002075.3	0.65	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.98 out of 23.79

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.09 out of 20.47

Confidence: medium

Additional weak hits (12):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.66 out of 29.38

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.41 out of 30.25

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.29 out of 28.14

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 19.59 out of 33.73

Confidence: weak

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.07 out of 27.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.17 out of 26.06

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.25 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.99 out of 29.38

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.34 out of 28.19

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.95 out of 28.19

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 19.56 out of 27.04

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.10 out of 23.43

Confidence: weak

Module view

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Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 120782 - 189630:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (Gly - NMe-X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 120782 - 161751:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly - NMe-X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 135082 - 189630:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X) + (Gly - NMe-X)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

MQC87_RS36700: X

AMP-binding (359..526): X

No predictions made

MQC87_RS36745: Gly - X

Search NORINE for peptide: strict or relaxed

AMP-binding (24..428): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FCLTFDIAALELQGLCGGEWNLYGPTETTIWSLL
Nearest Stachelhaus code(s):: Gly DILQLGLIWK (88% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1093..1500): X

nrpys: Phe, Trp, Ph-Gly, Tyr, bOH-Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LSYSFDPTFCECTFMVAGEINAYGPTEATVDTLY
Nearest Stachelhaus code(s):: bOH-Tyr DASTIAAVDK (56% 8Å match)
Stachelhaus code match:: 70% (weak)

MQC87_RS36775: X

AMP-binding (18..416): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Unpolar aromatic ring (Phe, Trp)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: FNPAFDTFHWESLSQTGGDVNLYGPTEGTTAATA
Nearest Stachelhaus code(s):: Leu DAWLAGLTAK (74% 8Å match)
Stachelhaus code match:: 80% (moderate)