Select genomic region:
Overview
1.1
8.1
8.2
9.1
13.1
14.1
15.1
18.1
20.1
20.2
22.1
25.1
27.1
27.2
31.1
32.1
32.2
32.3
32.4
32.5
34.1
35.1
36.1
36.2
36.3
36.4
37.1
37.2
37.3
37.4
38.1
38.2
39.1
40.1
40.2
40.3
40.4
41.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_JALDPQ010000007.1 (Streptomyces sp. TRM75563)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | NRPS | 50,666 | 90,172 | Low | azotobactin D | NRPS:Type I

NZ_JALDPQ010000035.1 (Streptomyces sp. TRM75563)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 8.1 | NRPS,melanin | 1 | 52,305 | Low | matlystatin A | NRPS:Type I+PKS
Region 8.2 | terpene | 69,927 | 93,881 | High | isorenieratene | terpene

NZ_JALDPQ010000036.1 (Streptomyces sp. TRM75563)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 9.1 | NRPS,T1PKS | 180,210 | 243,020 | Low | K-41A | PKS

NZ_JALDPQ010000040.1 (Streptomyces sp. TRM75563)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 13.1 | lassopeptide | 82,118 | 104,653 | High | albusnodin | ribosomal:RiPP

NZ_JALDPQ010000041.1 (Streptomyces sp. TRM75563)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 14.1 | lanthipeptide-class-iv | 51,078 | 73,948 | Low | labyrinthopeptin A2/labyrinthopeptin A1/labyrinthopeptin A3 | ribosomal:RiPP:Lanthipeptide

NZ_JALDPQ010000042.1 (Streptomyces sp. TRM75563)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 15.1 | lassopeptide,NRPS,T1PKS | 31,497 | 90,009 | High | SRO15-2005 | ribosomal:unmodified

NZ_JALDPQ010000045.1 (Streptomyces sp. TRM75563)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 18.1 | terpene | 69,380 | 90,456 | Low | steffimycin D | PKS:Type II+saccharide:hybrid/tailoring

NZ_JALDPQ010000047.1 (Streptomyces sp. TRM75563)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 20.1 | NRPS,T1PKS | 1,476 | 50,853 | High | SGR PTMs/SGR PTM Compound b/SGR PTM Compound c/SGR PTM Compound d | NRPS:Type I+PKS
Region 20.2 | terpene | 106,088 | 132,651 | Medium | hopene | terpene

NZ_JALDPQ010000049.1 (Streptomyces sp. TRM75563)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 22.1 | T1PKS | 1 | 4,284 |

NZ_JALDPQ010000052.1 (Streptomyces sp. TRM75563)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 25.1 | NRPS,T1PKS | 78,717 | 131,271 |  |

NZ_JALDPQ010000054.1 (Streptomyces sp. TRM75563)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 27.1 | terpene-precursor | 1 | 18,111 |  |
Region 27.2 | lanthipeptide-class-ii | 106,662 | 132,962 |  |

NZ_JALDPQ010000058.1 (Streptomyces sp. TRM75563)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 31.1 | ectoine,butyrolactone | 32,952 | 48,382 | Medium | showdomycin | other:other

NZ_JALDPQ010000059.1 (Streptomyces sp. TRM75563)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 32.1 | T3PKS | 35,765 | 76,817 | High | 2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone/2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol | PKS:Type III
Region 32.2 | terpene-precursor,melanin | 93,422 | 121,914 | High | melanin | other:other
Region 32.3 | RiPP-like | 122,838 | 134,205 | Medium | streptamidine | ribosomal:unmodified
Region 32.4 | NRPS | 220,868 | 263,725 |  |
Region 32.5 | RiPP-like | 339,742 | 350,539 |  |

NZ_JALDPQ010000061.1 (Streptomyces sp. TRM75563)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 34.1 | hglE-KS,T1PKS,NRPS,NRPS-like,terpene | 192,578 | 287,687 | High | isorenieratene | terpene

NZ_JALDPQ010000062.1 (Streptomyces sp. TRM75563)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 35.1 | ectoine | 318,514 | 328,912 | High | ectoine | other:other

NZ_JALDPQ010000063.1 (Streptomyces sp. TRM75563)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 36.1 | T3PKS | 78,261 | 119,391 |  |
Region 36.2 | NRP-metallophore,NRPS | 146,261 | 245,499 | High | griseobactin | NRPS:Type I
Region 36.3 | terpene | 306,135 | 328,348 | High | geosmin | terpene:Sesquiterpene
Region 36.4 | butyrolactone | 361,521 | 372,465 | Low | coelimycin P1 | PKS:Type I

NZ_JALDPQ010000064.1 (Streptomyces sp. TRM75563)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 37.1 | terpene | 146,300 | 167,277 |
Region 37.2 | terpene-precursor | 383,678 | 404,721 |  |
Region 37.3 | lanthipeptide-class-iii | 517,863 | 540,586 | High | AmfS | ribosomal:RiPP:Lanthipeptide
Region 37.4 | T1PKS,NRPS-like | 604,093 | 658,864 |  |

NZ_JALDPQ010000065.1 (Streptomyces sp. TRM75563)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 38.1 | lanthipeptide-class-ii,lanthipeptide-class-iii | 10,114 | 41,386 |
Region 38.2 | NI-siderophore | 85,276 | 115,054 | High | desferrioxamin B | other:other

NZ_JALDPQ010000066.1 (Streptomyces sp. TRM75563)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 39.1 | azole-containing-RiPP,RRE-containing | 151,935 | 186,770 |

NZ_JALDPQ010000067.1 (Streptomyces sp. TRM75563)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 40.1 | NI-siderophore | 57,147 | 89,906 | Low | kinamycin | PKS
Region 40.2 | hydrogen-cyanide | 193,816 | 206,725 | Low | aborycin | ribosomal:RiPP
Region 40.3 | RiPP-like | 338,337 | 349,728 | Low | 14-hydroxyisochainin | PKS:Modular type I
Region 40.4 | ectoine | 748,613 | 758,987 | Low | kosinostatin | NRPS:Type I+PKS:Type II+saccharide:hybrid/tailoring

NZ_JALDPQ010000068.1 (Streptomyces sp. TRM75563)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 41.1 | PKS-like,NRPS,betalactone,NRPS-like | 120,783 | 189,630 |  |

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | NRPS | 50,666 | 90,172 | Low | azotobactin D | NRPS:Type I
Region 8.1 | NRPS,melanin | 1 | 52,305 | Low | matlystatin A | NRPS:Type I+PKS
Region 8.2 | terpene | 69,927 | 93,881 | High | isorenieratene | terpene
Region 9.1 | NRPS,T1PKS | 180,210 | 243,020 | Low | K-41A | PKS
Region 13.1 | lassopeptide | 82,118 | 104,653 | High | albusnodin | ribosomal:RiPP
Region 14.1 | lanthipeptide-class-iv | 51,078 | 73,948 | Low | labyrinthopeptin A2/labyrinthopeptin A1/labyrinthopeptin A3 | ribosomal:RiPP:Lanthipeptide
Region 15.1 | lassopeptide,NRPS,T1PKS | 31,497 | 90,009 | High | SRO15-2005 | ribosomal:unmodified
Region 18.1 | terpene | 69,380 | 90,456 | Low | steffimycin D | PKS:Type II+saccharide:hybrid/tailoring
Region 20.1 | NRPS,T1PKS | 1,476 | 50,853 | High | SGR PTMs/SGR PTM Compound b/SGR PTM Compound c/SGR PTM Compound d | NRPS:Type I+PKS
Region 20.2 | terpene | 106,088 | 132,651 | Medium | hopene | terpene
Region 22.1 | T1PKS | 1 | 4,284 |
Region 25.1 | NRPS,T1PKS | 78,717 | 131,271 |  |
Region 27.1 | terpene-precursor | 1 | 18,111 |  |
Region 27.2 | lanthipeptide-class-ii | 106,662 | 132,962 |  |
Region 31.1 | ectoine,butyrolactone | 32,952 | 48,382 | Medium | showdomycin | other:other
Region 32.1 | T3PKS | 35,765 | 76,817 | High | 2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone/2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol | PKS:Type III
Region 32.2 | terpene-precursor,melanin | 93,422 | 121,914 | High | melanin | other:other
Region 32.3 | RiPP-like | 122,838 | 134,205 | Medium | streptamidine | ribosomal:unmodified
Region 32.4 | NRPS | 220,868 | 263,725 |  |
Region 32.5 | RiPP-like | 339,742 | 350,539 |  |
Region 34.1 | hglE-KS,T1PKS,NRPS,NRPS-like,terpene | 192,578 | 287,687 | High | isorenieratene | terpene
Region 35.1 | ectoine | 318,514 | 328,912 | High | ectoine | other:other
Region 36.1 | T3PKS | 78,261 | 119,391 |  |
Region 36.2 | NRP-metallophore,NRPS | 146,261 | 245,499 | High | griseobactin | NRPS:Type I
Region 36.3 | terpene | 306,135 | 328,348 | High | geosmin | terpene:Sesquiterpene
Region 36.4 | butyrolactone | 361,521 | 372,465 | Low | coelimycin P1 | PKS:Type I
Region 37.1 | terpene | 146,300 | 167,277 |
Region 37.2 | terpene-precursor | 383,678 | 404,721 |  |
Region 37.3 | lanthipeptide-class-iii | 517,863 | 540,586 | High | AmfS | ribosomal:RiPP:Lanthipeptide
Region 37.4 | T1PKS,NRPS-like | 604,093 | 658,864 |  |
Region 38.1 | lanthipeptide-class-ii,lanthipeptide-class-iii | 10,114 | 41,386 |
Region 38.2 | NI-siderophore | 85,276 | 115,054 | High | desferrioxamin B | other:other
Region 39.1 | azole-containing-RiPP,RRE-containing | 151,935 | 186,770 |
Region 40.1 | NI-siderophore | 57,147 | 89,906 | Low | kinamycin | PKS
Region 40.2 | hydrogen-cyanide | 193,816 | 206,725 | Low | aborycin | ribosomal:RiPP
Region 40.3 | RiPP-like | 338,337 | 349,728 | Low | 14-hydroxyisochainin | PKS:Modular type I
Region 40.4 | ectoine | 748,613 | 758,987 | Low | kosinostatin | NRPS:Type I+PKS:Type II+saccharide:hybrid/tailoring
Region 41.1 | PKS-like,NRPS,betalactone,NRPS-like | 120,783 | 189,630 |  |

No secondary metabolite regions were found in these records:
  NZ_JALDPQ010000018.1 (Streptomyces sp. TRM75563)
  NZ_JALDPQ010000022.1 (Streptomyces sp. TRM75563)
  NZ_JALDPQ010000024.1 (Streptomyces sp. TRM75563)
  NZ_JALDPQ010000032.1 (Streptomyces sp. TRM75563)
  NZ_JALDPQ010000033.1 (Streptomyces sp. TRM75563)
  NZ_JALDPQ010000034.1 (Streptomyces sp. TRM75563)
  NZ_JALDPQ010000037.1 (Streptomyces sp. TRM75563)
  NZ_JALDPQ010000038.1 (Streptomyces sp. TRM75563)
  NZ_JALDPQ010000039.1 (Streptomyces sp. TRM75563)
  NZ_JALDPQ010000043.1 (Streptomyces sp. TRM75563)
  NZ_JALDPQ010000044.1 (Streptomyces sp. TRM75563)
  NZ_JALDPQ010000046.1 (Streptomyces sp. TRM75563)
  NZ_JALDPQ010000048.1 (Streptomyces sp. TRM75563)
  NZ_JALDPQ010000050.1 (Streptomyces sp. TRM75563)
  NZ_JALDPQ010000051.1 (Streptomyces sp. TRM75563)
  NZ_JALDPQ010000053.1 (Streptomyces sp. TRM75563)
  NZ_JALDPQ010000055.1 (Streptomyces sp. TRM75563)
  NZ_JALDPQ010000056.1 (Streptomyces sp. TRM75563)
  NZ_JALDPQ010000057.1 (Streptomyces sp. TRM75563)
  NZ_JALDPQ010000060.1 (Streptomyces sp. TRM75563)
  NZ_JALDPQ010000005.1 (Streptomyces sp. TRM75563)

Compact view
NZ_JALDPQ010000007.1 - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 50,666 - 90,172 nt. (total: 39,507 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: esterase
MQC87_RS37545: enterobactin/ferric enterobactin esterase

smcogs
  SMCOG1098: enterobactin/ferric enterobactin esterase

Isomerases: mutase
MQC87_RS00310: phosphoglycerate mutase

smcogs
  SMCOG1101: phosphoglycerate mutase

Ligases: ligase
MQC87_RS00405: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

MQC87_RS00410: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

MQC87_RS00415: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

MQC87_RS00420: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

MQC87_RS00435: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002075.3 |  | 0.75 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0001132.4 |  | 0.71 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  | 0.71 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.4 |  | 0.71 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4 |  | 0.70 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0000342.4 |  | 0.69 | NRPS | enniatin | Fusarium equiseti
BGC0001758.4 |  | 0.69 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0002286.3 |  | 0.69 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2 |  | 0.69 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001250.4 |  | 0.68 | NRPS | epichloenin A | Epichloe festucae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002075.3 |  | 0.75 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0001132.4 |  | 0.71 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  | 0.71 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.4 |  | 0.71 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4 |  | 0.70 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0000342.4 |  | 0.69 | NRPS | enniatin | Fusarium equiseti
BGC0001758.4 |  | 0.69 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0002286.3 |  | 0.69 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2 |  | 0.69 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001250.4 |  | 0.68 | NRPS | epichloenin A | Epichloe festucae

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.60 out of 19.26
Confidence: medium
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 28.73 out of 36.53
Confidence: medium
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 22.54 out of 27.04
Confidence: medium
Additional weak hits (13):
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.88 out of 39.62
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.61 out of 39.62
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.32 out of 39.62
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.23 out of 39.62
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 16.41 out of 31.73
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.85 out of 27.78
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 15.86 out of 31.73
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 18.61 out of 30.97
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.29 out of 26.06
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 16.71 out of 29.25
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 16.89 out of 30.97
Confidence: weak
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.22 out of 20.97
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 15.58 out of 33.14
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 50665 - 90172:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Lys) + (Ser) + (Gly)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
MQC87_RS00405: Lys
Search NORINE for peptide: strict or relaxed
AMP-binding (489..914): Lys
nrpys: Lys

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    RWMAFDTHAEEPDLILGADVNSYGPTETTVIAAT
  Nearest Stachelhaus code(s):
    Lys DTEDIGSVIK (74% 8Å match)
  Stachelhaus code match:
    100% (strong)

MQC87_RS00410: Ser
Search NORINE for peptide: strict or relaxed
AMP-binding (517..918): Ser
nrpys: Ser

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    ser (Ser)
  Single AA prediction:
    ser (Ser)

Stachelhaus prediction details:
  Stachelhaus sequence:
    RWMTFDVSVWELHFVCSGEANLYGPTEAAVDVTS
  Nearest Stachelhaus code(s):
    Ser DVWHVSLVDK (91% 8Å match)
  Stachelhaus code match:
    100% (strong)

MQC87_RS00415: X
AMP-binding (38..439): X
nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    GLDFTNAGQTMNFLGSTAAVNYYTSTEAAPAQIT
  Nearest Stachelhaus code(s):
  Stachelhaus code match:
    0% (weak)

MQC87_RS00420: Gly
Search NORINE for peptide: strict or relaxed
AMP-binding (452..853): Gly
nrpys: Gly

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    gly (Gly)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LALTFDISTVELQALAGGEINVYGPTETTVWSTL
  Nearest Stachelhaus code(s):
    Gly DILQLGVVWK (74% 8Å match)
  Stachelhaus code match:
    90% (moderate)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
DasR | N-acetylglucosamine dependent repressor
DmdR1 | Iron(II)-dependent repressor

NZ_JALDPQ010000035.1 - Region 1 - NRPS,melanin
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 52,305 nt. (total: 52,305 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
melanin: melC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxygenase
MQC87_RS01045: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs
  SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

MQC87_RS01090: lysine/ornithine N-monooxygenase

smcogs
  SMCOG1080: lysine/ornithine N-monooxygenase

Transferases: halogenase
MQC87_RS01075: halogenase

smcogs
  SMCOG1119: halogenase

Hydrolases: deformylase
MQC87_RS01030: peptide deformylase

smcogs
  SMCOG1275: peptide deformylase

Ligases: ligase
MQC87_RS01050: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

MQC87_RS01055: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

MQC87_RS01070: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | melanin | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000909.3 |  |  | 0.59 | other (other) | melanin | Streptomyces avermitilis
BGC0000912.3 |  |  | 0.55 | other (other) | melanin | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000910.3 |  |  | 0.53 | other (other) | melanin | Streptomyces coelicolor A3(2)
BGC0000911.3 |  |  | 0.52 | other (other) | melanin | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000908.3 |  |  | 0.48 | other (other) | melanin | Streptomyces avermitilis
BGC0001132.4 |  |  | 0.40 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.4 |  |  | 0.40 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001833.4 |  |  | 0.40 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002135.2 |  |  | 0.39 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001128.4 |  |  | 0.39 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001132.4 |  | 0.72 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.4 |  | 0.72 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001833.4 |  | 0.72 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002135.2 |  | 0.71 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001128.4 |  | 0.71 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.71 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  | 0.70 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001261.3 |  | 0.70 | NRPS | AM-toxin | Alternaria alternata
BGC0001135.5 |  | 0.69 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001166.5 |  | 0.68 | NRPS | HC-toxin | Alternaria jesenskae

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.46 out of 23.05
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.21 out of 28.19
Confidence: medium
Additional weak hits (16):
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 19.22 out of 31.73
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.23 out of 32.74
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.79 out of 29.38
Confidence: weak
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.64 out of 21.84
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.01 out of 30.25
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.25 out of 30.25
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 18.28 out of 29.25
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 19.59 out of 33.73
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.58 out of 29.38
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.64 out of 28.14
Confidence: weak
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.67 out of 26.33
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.41 out of 36.53
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 21.21 out of 32.74
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 19.57 out of 35.63
Confidence: weak
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.15 out of 18.57
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.41 out of 28.14
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 52305:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Ser - D-X - X - X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
MQC87_RS01055: X
AMP-binding (25..419): X
nrpys: Piz

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    MWQAFDVSFQEGFVNTAGEVNHYGQSESAMVTSH
  Nearest Stachelhaus code(s):
    Piz DVQFNAHMVK (88% 8Å match)
  Stachelhaus code match:
    100% (strong)

MQC87_RS01070: Ser - X - X - X
Search NORINE for peptide: strict or relaxed
AMP-binding (472..878): Ser
nrpys: Ser

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LSTHFDVSVWEGSQVFAGEINMYGTTETTVHASF
  Nearest Stachelhaus code(s):
    Ser DVWSVAMVHK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1542..1940): X
nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LTHHFDFAVWEGTQLVGGEINAYGPTECTVYASM
  Nearest Stachelhaus code(s):
    Phe DFWTVAAVCK (71% 8Å match)
    Val DFESLAAVYK (50% 8Å match)
  Stachelhaus code match:
    70% (weak)

AMP-binding (3049..3437): X
nrpys: Ile, Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LLSHFDVSVWEGTQFVGGEINAYGPTEGTVYASM
  Nearest Stachelhaus code(s):
    Leu or Ile DVWTIGAVDK (62% 8Å match)
  Stachelhaus code match:
    80% (moderate)

AMP-binding (4101..4488): X
nrpys: (unknown)

SVM prediction details:
  Predicted physicochemical class:
    N/A
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    MSSHFDVSVWEGNQFVGGEINGYGETETFYASMS
  Nearest Stachelhaus code(s):
    dmeaTrp or 1Me-Trp DVWTHGGVAK (50% 8Å match)
    dmeaTrp DVWTHGGVAK (47% 8Å match)
  Stachelhaus code match:
    70% (weak)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsR | Pleiotropic regulatory for antibiotic production
ZuR variant 1 | Zinc-responsive repressor

NZ_JALDPQ010000035.1 - Region 2 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 69,927 - 93,881 nt. (total: 23,955 nt) Show pHMM detection rules used
Region on contig edge.
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
MQC87_RS01275: dehydrogenase

smcogs
  SMCOG1222: dehydrogenase

Transferases: methyltransferase
MQC87_RS01295: methyltransferase

smcogs
  SMCOG1089: methyltransferase

Hydrolases: hydrolase
MQC87_RS01250: alpha/beta hydrolase fold protein

smcogs
  SMCOG1036: alpha/beta hydrolase fold protein

Ligases: synthetase
MQC87_RS01270: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000664.5 |  | 0.88 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000649.3 |  | 0.79 | terpene | carotenoid | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001456.3 |  | 0.75 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000633.3 |  | 0.71 | terpene | carotenoid | Streptomyces avermitilis
BGC0001227.3 |  | 0.71 | terpene | isorenieratene | Streptomyces collinus Tu 365
BGC0000648.3 |  | 0.53 | terpene | carotenoid | Myxococcus xanthus
BGC0000645.3 |  | 0.53 | terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0000646.5 |  | 0.51 | terpene | β-carotein | uncultured bacterium
BGC0000640.3 |  | 0.50 | terpene | carotenoid | Enterobacteriaceae bacterium DC404
BGC0000639.3 |  | 0.49 | terpene | carotenoid | Enterobacteriaceae bacterium DC260

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000664.5 |  | 0.88 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000649.3 |  | 0.79 | terpene | carotenoid | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001456.3 |  | 0.75 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000633.3 |  | 0.71 | terpene | carotenoid | Streptomyces avermitilis
BGC0001227.3 |  | 0.71 | terpene | isorenieratene | Streptomyces collinus Tu 365
BGC0000648.3 |  | 0.53 | terpene | carotenoid | Myxococcus xanthus
BGC0000645.3 |  | 0.53 | terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0000646.5 |  | 0.51 | terpene | β-carotein | uncultured bacterium
BGC0000640.3 |  | 0.50 | terpene | carotenoid | Enterobacteriaceae bacterium DC404
BGC0000639.3 |  | 0.49 | terpene | carotenoid | Enterobacteriaceae bacterium DC260

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
tetraterpene | C40 carotenoid |  | C40 | unknown | unknown

Genes with terpene domains:
MQC87_RS01270: PT_FPPS_like
Domain 1 (53 - 363): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: unknown

Reactions:
  IPP, DMAPP → FPP
  IPP, DMAPP → GGPP
  IPP, DMAPP → GFPP
  IPP, DMAPP → HPP

MQC87_RS01280: PT_phytoene_like
Domain 1 (16 - 326): Prenyltransferase; Phytoene synthase like
Subtype: unknown

Reactions:
  FPP → PSPP
  FPP → squalene
  FPP → diapophytoene
  GGPP → phytoene
  PSPP → hydroxysqualene

MQC87_RS01300: Lycopene_cycl
Domain 1 (6 - 385): Lycopene cyclase

Reactions:
  C40_carotenoid → C40_carotenoid

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 19.35 out of 20.47
Confidence: strong
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 24.59 out of 29.72
Confidence: medium
Additional weak hits (6):
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.99 out of 26.85
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.06 out of 26.06
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 15.26 out of 28.14
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.43 out of 27.78
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.87 out of 27.78
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.87 out of 26.06
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
GFPP | Geranylfarnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
HPP | Hexaprenyl diphosphate
IPP | Isopentenyl diphosphate
PSPP | Presqualene diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
NtrC | Nitrogen regulatory protein C
VqsM | Regulator of quorum-sensing signalling systems

NZ_JALDPQ010000036.1 - Region 1 - NRPS,T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 180,210 - 243,020 nt. (total: 62,811 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidase oxidoreductase oxygenase
MQC87_RS02315: lysine/ornithine N-monooxygenase

smcogs
  SMCOG1080: lysine/ornithine N-monooxygenase

MQC87_RS02330: oxidoreductase

smcogs
  SMCOG1079: oxidoreductase

MQC87_RS02375: cytochrome P450

smcogs
  SMCOG1007: cytochrome P450

MQC87_RS02380: FAD linked oxidase domain protein

smcogs
  SMCOG1138: FAD linked oxidase domain protein

MQC87_RS02390: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

Transferases: acyltransferase aminotransferase glycosyltransferase transferase
MQC87_RS02320: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs
  SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

MQC87_RS02340: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs
  SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

MQC87_RS02350: glycosyltransferase, MGT family

smcogs
  SMCOG1062: glycosyltransferase, MGT family

MQC87_RS02355: glycosyltransferase, MGT family

smcogs
  SMCOG1062: glycosyltransferase, MGT family

MQC87_RS02365: polyketide synthase associated protein papA3

smcogs
  SMCOG1209: polyketide synthase associated protein papA3

MQC87_RS02395: glycosyltransferase, MGT family

smcogs
  SMCOG1062: glycosyltransferase, MGT family

Hydrolases: esterase
MQC87_RS02285: thioesterase

smcogs
  SMCOG1004: thioesterase

MQC87_RS02400: thioesterase

smcogs
  SMCOG1004: thioesterase

Lyases: dehydratase
MQC87_RS02325: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

MQC87_RS02345: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: ligase synthase
MQC87_RS02385: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

MQC87_RS02405: Beta-ketoacyl synthase

smcogs
  SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | T1PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001132.4 |  |  | 0.76 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  |  | 0.74 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  |  | 0.74 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0002135.2 |  |  | 0.74 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001128.4 |  |  | 0.74 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  |  | 0.72 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0002075.3 |  |  | 0.72 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0002286.3 |  |  | 0.72 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000342.4 |  |  | 0.71 | NRPS | enniatin | Fusarium equiseti
BGC0001135.5 |  |  | 0.71 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002075.3 |  | 0.73 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0001132.4 |  | 0.73 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  | 0.72 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  | 0.72 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001128.4 |  | 0.72 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2 |  | 0.71 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0002286.3 |  | 0.71 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  | 0.70 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001261.3 |  | 0.69 | NRPS | AM-toxin | Alternaria alternata
BGC0001135.5 |  | 0.69 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Location:
Identifier
Identity
Coverage
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.76 out of 23.05
Confidence: medium
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.82 out of 18.46
Confidence: medium
Additional weak hits (11):
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.97 out of 39.62
Confidence: weak
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.20 out of 26.85
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.72 out of 27.78
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.55 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.80 out of 26.06
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.06 out of 29.38
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.08 out of 27.78
Confidence: weak
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.59 out of 22.40
Confidence: weak
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.86 out of 26.85
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.71 out of 26.06
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.52 out of 28.19
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 180209 - 243020:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (ccmal) + (redmal) + (Tyr - NMe-Phe) + (D-Leu - Leu - D-X - X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 212892 - 243020:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (ccmal) + (redmal) + (Tyr - NMe-Phe) + (D-Leu - Leu - D-X - X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
MQC87_RS02365: Leu - Leu - X - X
Search NORINE for peptide: strict or relaxed
AMP-binding (468..857): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    GRLTFDVSVFETSTVFAGEVNAYGQTESFYATVF
  Nearest Stachelhaus code(s):
    Leu DVFSVAAYAK (88% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (2021..2411): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    N/A
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    GRLTFDVSVFETSTVFAGEVNAYGQTESFYATTY
  Nearest Stachelhaus code(s):
    Leu DVFSVAAYAK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (3084..3478): X
nrpys: (unknown)

SVM prediction details:
  Predicted physicochemical class:
    N/A
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    Unpolar aromatic ring (Phe, Trp)
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LTTAFDAAFWEQMLTVGGEVNAYGPTETTVCGAI
  Nearest Stachelhaus code(s):
    Leu DAWMVGAVCK (65% 8Å match)
  Stachelhaus code match:
    90% (moderate)

AMP-binding (4626..5027): X
nrpys: Phe, Trp, Ph-Gly, Tyr, bOH-Tyr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LDRNFDTSTYEVAMWTVGDVNGYGPTETTAATSM
  Nearest Stachelhaus code(s):
    Abu DTYWWGGTFK (68% 8Å match)
  Stachelhaus code match:
    60% (weak)

MQC87_RS02385: Tyr - Phe
Search NORINE for peptide: strict or relaxed
AMP-binding (465..864): Tyr
nrpys: Tyr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    Polar aromatic ring (Tyr, bOH-Tyr)
  Single AA prediction:
    tyr (Tyr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LAQAFDAAVSEMTLIVAGEINAYGPTEATVCATM
  Nearest Stachelhaus code(s):
    Tyr DASTIAAVCK (97% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1524..1923): Phe
nrpys: Phe

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    Unpolar aromatic ring (Phe, Trp)
  Single AA prediction:
    phe (Phe)

Stachelhaus prediction details:
  Stachelhaus sequence:
    VLQAFDSAVWEFTLIVAGEINGYGPTEATVSATM
  Nearest Stachelhaus code(s):
    His DTWTIASVSK (74% 8Å match)
    Phe DAWTIAGVCK (56% 8Å match)
  Stachelhaus code match:
    80% (moderate)

MQC87_RS02405: mal
PKS_AT (574..873): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 91.7%
  inactive: 79.2%
  2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 163.4
  inactive: 89.8
  Methoxymalonyl-CoA: 62.6
  Methylmalonyl-CoA: 57.8
  Propionyl-CoA: 30.4
  Ethylmalonyl-CoA: 24.9
  Benzoyl-CoA: 23.7
  CHC-CoA: 21.0
  Isobutyryl-CoA: 19.3
  Acetyl-CoA: 15.8
  trans-1,2-CPDA: 15.2
  2-Methylbutyryl-CoA: 14.2
  fatty_acid: 12.4
  3-Methylbutyryl-CoA: 0.0

MQC87_RS02410: mal
PKS_AT (0..215): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 66.7%
  inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 154.9
  inactive: 79.0
  Methoxymalonyl-CoA: 64.4
  Methylmalonyl-CoA: 54.7
  Isobutyryl-CoA: 23.1
  Ethylmalonyl-CoA: 21.9
  Propionyl-CoA: 21.3
  2-Methylbutyryl-CoA: 20.8
  Acetyl-CoA: 13.4
  Benzoyl-CoA: 12.1
  trans-1,2-CPDA: 11.3
  fatty_acid: 10.5
  CHC-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsR | Pleiotropic regulatory for antibiotic production
RpoN | Regulator of nitrogen assimilation and virulence

NZ_JALDPQ010000040.1 - Region 1 - lassopeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 82,118 - 104,653 nt. (total: 22,536 nt) Show pHMM detection rules used
lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lasso peptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: acetyltransferase
MQC87_RS03685: GCN5-related N-acetyltransferase

smcogs
  SMCOG1111: GCN5-related N-acetyltransferase

Hydrolases: hydrolase
MQC87_RS03695: asparagine synthase (glutamine-hydrolyzing)

smcogs
  SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lassopeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002006.2 |  | 0.78 | ribosomal | albusnodin | Streptomyces albus
BGC0001552.3 |  | 0.44 | ribosomal | citrulassin F | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0002298.2 |  | 0.44 | ribosomal | lassomycin-like peptide | Sanguibacter keddieii DSM 10542
BGC0001548.4 |  | 0.43 | ribosomal | citrulassin A | Streptomyces albulus
BGC0001549.3 |  | 0.43 | ribosomal | citrulassin B | Streptomyces aurantiacus JA 4570
BGC0002053.3 |  | 0.43 | ribosomal | ulleungdin | Streptomyces sp.
BGC0001634.3 |  | 0.43 | ribosomal | keywimysin | Streptomyces sp. NRRL F-5702
BGC0001550.3 |  | 0.43 | ribosomal | citrulassin D | Streptomyces katrae
BGC0000575.5 |  | 0.43 | ribosomal | lariatin | Rhodococcus jostii
BGC0001493.5 |  | 0.42 | ribosomal | achromosin | Streptomyces achromogenes subsp. achromogenes

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002006.2 |  | 0.78 | ribosomal | albusnodin | Streptomyces albus
BGC0001552.3 |  | 0.44 | ribosomal | citrulassin F | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0002298.2 |  | 0.44 | ribosomal | lassomycin-like peptide | Sanguibacter keddieii DSM 10542
BGC0001548.4 |  | 0.43 | ribosomal | citrulassin A | Streptomyces albulus
BGC0001549.3 |  | 0.43 | ribosomal | citrulassin B | Streptomyces aurantiacus JA 4570
BGC0002053.3 |  | 0.43 | ribosomal | ulleungdin | Streptomyces sp.
BGC0001634.3 |  | 0.43 | ribosomal | keywimysin | Streptomyces sp. NRRL F-5702
BGC0001550.3 |  | 0.43 | ribosomal | citrulassin D | Streptomyces katrae
BGC0000575.5 |  | 0.43 | ribosomal | lariatin | Rhodococcus jostii
BGC0001493.5 |  | 0.42 | ribosomal | achromosin | Streptomyces achromogenes subsp. achromogenes

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lasso peptide predictions
Lists the possible core peptides for each biosynthetic enzyme. Each core peptide shows the leader and core peptide sequences.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.
Lassopeptides - No core peptides found.
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.46 out of 23.05
Confidence: medium
CsoR
Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 27.35 out of 32.38
Confidence: medium
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.27 out of 26.85
Confidence: medium
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05
Confidence: medium
Additional weak hits (3):
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.78 out of 20.01
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 19.64 out of 36.54
Confidence: weak
RicR
Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 24.15 out of 32.93
Confidence: weak
Lasso peptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of disulfide bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.
No core peptides found.
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsR | Pleiotropic regulatory for antibiotic production
CsoR | Copper-responsive repressor
RutR | Regulator of the pyrimidine and purine metabolism

NZ_JALDPQ010000041.1 - Region 1 - lanthipeptide-class-iv
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 51,078 - 73,948 nt. (total: 22,871 nt) Show pHMM detection rules used
Region on contig edge.
lanthipeptide-class-iv: (cds(LANC_like and Pkinase) and not micKC)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-iv | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000551.5 |  | 0.61 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000501.3 |  | 0.59 | ribosomal | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0000496.5 |  | 0.59 | ribosomal | AmfS | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000563.4 |  | 0.58 | ribosomal | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0002337.2 |  | 0.57 | ribosomal | class IV lanthipeptide, SflA | Streptomyces sp. NRRL S-1022
BGC0000519.4 |  | 0.56 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0001226.4 |  | 0.53 | ribosomal | streptocollin | Streptomyces collinus Tu 365
BGC0002698.2 |  | 0.51 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0000513.3 |  | 0.47 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0000518.3 |  | 0.45 | ribosomal | informatipeptin | Streptomyces viridochromogenes DSM 40736

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000551.5 |  | 0.61 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000501.3 |  | 0.59 | ribosomal | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0000496.5 |  | 0.59 | ribosomal | AmfS | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000563.4 |  | 0.58 | ribosomal | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0002337.2 |  | 0.57 | ribosomal | class IV lanthipeptide, SflA | Streptomyces sp. NRRL S-1022
BGC0000519.4 |  | 0.56 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0001226.4 |  | 0.53 | ribosomal | streptocollin | Streptomyces collinus Tu 365
BGC0002698.2 |  | 0.51 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0000513.3 |  | 0.47 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0000518.3 |  | 0.45 | ribosomal | informatipeptin | Streptomyces viridochromogenes DSM 40736

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for MQC87_RS04420

MQC87_RS04410
Leader:
MIDNTMTVDVDELQTLEGEESVALAG
Core:
C T R T C T W T C S I T S I E Q Q
Core with dehydrations:
Cys Dhb R Dhb Cys Dhb W Dhb Cys Dha I Dhb Dha I E Q Q

#### antiSMASH-DB 4.0 matches for MQC87_RS04410

100.0%
NZ_BMRY01000001.1 and 16 others:
NZ_BNBJ01000011.1 Lanthipeptides: IE304_RS20740_lanthipeptide NZ_CP013738.1 Lanthipeptides: WQO_RS36570_lanthipeptide NZ_CP029361.1 Lanthipeptides: DIJ69_RS35105_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS21260_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS33035_lanthipeptide NZ_CP090837.1 Lanthipeptides: LZ559_RS20475_lanthipeptide NZ_JALDPQ010000041.1 Lanthipeptides: MQC87_RS04410_lanthipeptide NZ_JAMFLF010000024.1 Lanthipeptides: M1212_RS34580_lanthipeptide NZ_KL573566.1 Lanthipeptides: BG84_RS1000000140120_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS35670_lanthipeptide NZ_KZ819182.1 Lanthipeptides: DBP21_RS35710_lanthipeptide NZ_LIVT01000009.1 Lanthipeptides: AMK24_RS34305_lanthipeptide NZ_LIXK01000001.1 Lanthipeptides: AMK23_RS37735_lanthipeptide NZ_ML123117.1 Lanthipeptides: EES46_RS36000_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS33060_lanthipeptide NZ_WWGD01000043.1 Lanthipeptides: GTY72_RS37555_lanthipeptide
Lanthipeptides: IE140_RS05545_lanthipeptide
1
C T R T C T W T C S I T S I E Q Q
17
C T R T C T W T C S I T S I E Q Q
1
C T R T C T W T C S I T S I E Q Q
17
94.1%
NZ_JNLT01000004.1:
Lanthipeptides: CD02_RS38845_lanthipeptide
1
C T R T C T W T C S I T S I E Q Q
17
C T+T C T W T C S I T S I E Q Q
1
C T K T C T W T C S I T S I E Q Q
17
82.4%
NZ_LZRD01000027.1:
Lanthipeptides: A3Q37_RS37510_lanthipeptide
1
C T R T C T W T C S I T S I E Q Q
17
C T+T C T W T C I T S+E Q Q
1
C T K T C T W T C R I T S L E Q Q
17
with 8 more sequence matches
82.4%
NZ_ML123034.1:
Lanthipeptides: EES43_RS30965_lanthipeptide
1
C T R T C T W T C S I T S I E Q Q
17
C T T C W T C+I T S I E Q Q
1
C T A T C A W T C A I T S I E Q Q
17
72.2%
NZ_PGGV01000018.1:
Lanthipeptides: CUT39_RS20215_lanthipeptide
1
C T R T C T W T C S I T S I E Q
16
C T T C T W T C S I T S +Q
3
C T W T C T W T C S I T S F Q Q
18
40.9%
NZ_CP017708.2 and 1 other:
NZ_CP017708.2 Lanthipeptides: BJP36_RS08575_lanthipeptide
Lanthipeptides: BJP36_RS08575_lanthipeptide
1
C T R T C T W T C S I T S I E Q Q
17
C T C +T C +T I+Q Q
1
C G H T C G Y T C G V T E I K Q Q
17
38.9%
NZ_CP017599.1 and 1 other:
NZ_CP017599.1 Lanthipeptides: BJP34_RS13165_lanthipeptide
Lanthipeptides: BJP34_RS13165_lanthipeptide
4
T C T W T C S I T S I E Q Q
17
+C T +C I T I Q
3
S C T V S C L I T I I N N Q
16
33.3%
NC_017803.1:
Lanthipeptides: ACPL_RS45060_lanthipeptide
1
C T R T C T W T C S I T S
13
C T C T C S+T
8
C K G T C P A T C S V T G
20
33.3%
NZ_BROP01000004.1:
Lanthipeptides: OPC11_RS12060_lanthipeptide
1
C T R T C T W T C S I T
12
C T C T +C++T
4
C L L T C T V S C A V T
15
25.0%
NZ_VATK01000028.1:
Lanthipeptides: FDO66_RS19480_lanthipeptide
3
R T C T W T C S I T
12
R C W C S T
1
R P C G W I C S Y T
10
9.8%
NZ_CP040414.1:
Lanthipeptides: FE331_RS05905_lanthipeptide
1
C T R T C T W T C
9
C R+C W C
38
C N R S C G W G C
46

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.39 out of 19.26
Confidence: strong
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.07 out of 20.47
Confidence: medium
Additional weak hits (5):
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 21.87 out of 36.53
Confidence: weak
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.70 out of 27.04
Confidence: weak
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.18 out of 26.85
Confidence: weak
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.40 out of 21.84
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.18 out of 28.19
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

MQC87_RS04410 - Class III
  Cleavage pHMM score: 2.70
  RODEO score: 0
  Monoisotopic mass: 1833.8 Da
  Molecular weight: 1835.1 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1853.1 Da N = 1
    1871.1 Da N = 2
    1889.1 Da N = 3
    1907.1 Da N = 4

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
VqsM | Regulator of quorum-sensing signalling systems

NZ_JALDPQ010000042.1 - Region 1 - NRPS,T1PKS,lassopeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 31,497 - 90,009 nt. (total: 58,513 nt) Show pHMM detection rules used
Region on contig edge.
lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lasso peptides
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxygenase
MQC87_RS04680: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs
  SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

MQC87_RS04890: cytochrome P450

smcogs
  SMCOG1007: cytochrome P450

MQC87_RS04900: cytochrome P450

smcogs
  SMCOG1007: cytochrome P450

Transferases: acylase aminotransferase
MQC87_RS04895: aminotransferase

smcogs
  SMCOG1019: aminotransferase

MQC87_RS04905: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: hydrolase
MQC87_RS04735: asparagine synthase (glutamine-hydrolyzing)

smcogs
  SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Ligases: ligase
MQC87_RS04885: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lassopeptide | NRPS | T1PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | ---
BGC0001634.3 |  |  |  | 0.67 | ribosomal | keywimysin | Streptomyces sp. NRRL F-5702
BGC0001825.4 |  |  |  | 0.61 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001240.4 |  |  |  | 0.61 | NRPS | serinocyclin A, serinocyclin B | Metarhizium robertsii
BGC0000357.5 |  |  |  | 0.57 | NRPS | cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val) | Penicillium rubens Wisconsin 54-1255
BGC0001275.3 |  |  |  | 0.53 | PKS | 6-methylsalicyclic acid | Glarea lozoyensis
BGC0001257.3 |  |  |  | 0.53 | PKS | 1,3,6,8-tetrahydroxynaphthalene | Nodulisporium sp. ATCC74245
BGC0001485.4 |  |  |  | 0.45 | other (other) | chuangxinmycin | Actinoplanes tsinanensis
BGC0001548.4 |  |  |  | 0.40 | ribosomal | citrulassin A | Streptomyces albulus
BGC0002825.2 |  |  |  | 0.39 | ribosomal | nocapeptin A | Nocardia terpenica IFM 0406
BGC0002171.2 |  |  |  | 0.39 | NRPS, PKS | pyrophen, campyrone B | Aspergillus niger ATCC 1015

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001634.3 |  | 0.88 | ribosomal | keywimysin | Streptomyces sp. NRRL F-5702
BGC0001548.4 |  | 0.72 | ribosomal | citrulassin A | Streptomyces albulus
BGC0001507.3 |  | 0.67 | ribosomal | anantin C | Streptomyces olindensis
BGC0001825.4 |  | 0.64 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001240.4 |  | 0.64 | NRPS | serinocyclin A, serinocyclin B | Metarhizium robertsii
BGC0001550.3 |  | 0.63 | ribosomal | citrulassin D | Streptomyces katrae
BGC0000357.5 |  | 0.62 | NRPS | cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val) | Penicillium rubens Wisconsin 54-1255
BGC0000578.3 |  | 0.62 | ribosomal | SRO15-2005 | Streptomyces filamentosus NRRL 15998
BGC0001645.3 |  | 0.61 | ribosomal | lagmysin | Streptomyces sp. NRRL S-118
BGC0001551.4 |  | 0.61 | ribosomal | citrulassin E | Streptomyces glaucescens

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lasso peptide predictions
Lists the possible core peptides for each biosynthetic enzyme. Each core peptide shows the leader and core peptide sequences.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lassopeptide(s) for MQC87_RS04740

MQC87_RS04740
Leader:
MKQQKKAYVKPSLFKQGDFSKKTA
Full core:
G Y F Y G S Y K E Y W V R R I I
Putative macrolactam:
G Y F Y G S Y K E

#### antiSMASH-DB 4.0 matches for MQC87_RS04740

100.0%
NZ_AQRK01000073.1 and 34 others:
NZ_ARPF01000020.1 Lassopeptides: B083_RS1000000135975_lassopeptide NZ_BMSP01000033.1 Lassopeptides: IE150_RS31095_lassopeptide NZ_BNBJ01000018.1 Lassopeptides: IE304_RS27885_lassopeptide NZ_CP011522.1 Lassopeptides: ABE83_RS36070_lassopeptide NZ_CP015362.1 Lassopeptides: A6E92_RS32825_lassopeptide NZ_CP020570.1 Lassopeptides: B1H20_RS34515_lassopeptide NZ_CP024957.1 Lassopeptides: CVT27_RS18750_lassopeptide NZ_CP030930.1 Lassopeptides: DTW94_RS18860_lassopeptide NZ_CP032543.1 Lassopeptides: D6270_RS18940_lassopeptide NZ_CP058556.1 Lassopeptides: HXS80_RS15025_lassopeptide NZ_CP059898.1 Lassopeptides: H3V39_RS14565_lassopeptide NZ_CP070242.1 Lassopeptides: I6J39_RS14950_lassopeptide NZ_CP070260.1 Lassopeptides: I6J40_RS19545_lassopeptide NZ_CP077652.1 Lassopeptides: KRR37_RS18710_lassopeptide NZ_CP079114.1 Lassopeptides: KV381_RS20695_lassopeptide NZ_CP101140.1 Lassopeptides: NF554_RS14180_lassopeptide NZ_CP101397.1 Lassopeptides: NLU04_RS02420_lassopeptide NZ_CP113262.1 Lassopeptides: OUQ49_RS18920_lassopeptide NZ_JAGGOV010000040.1 Lassopeptides: J7E92_RS24040_lassopeptide NZ_JAHHWT010000002.1 Lassopeptides: KM153_RS04955_lassopeptide NZ_JAJDST010000050.1 Lassopeptides: LJC81_RS32430_lassopeptide NZ_JALDPQ010000042.1 Lassopeptides: MQC87_RS04740_lassopeptide NZ_JAMFLF010000013.1 Lassopeptides: M1212_RS26530_lassopeptide NZ_JANRMN010000006.1 Lassopeptides: NW249_RS11850_lassopeptide NZ_KB890924.1 Lassopeptides: B053_RS1000000136555_lassopeptide NZ_KB891296.1 Lassopeptides: B061_RS39115_lassopeptide NZ_KL573564.1 Lassopeptides: BG84_RS1000000139430_lassopeptide NZ_KZ819159.1 Lassopeptides: DBP19_RS18270_lassopeptide NZ_LR881952.1 Lassopeptides: STRPST75_RS15280_lassopeptide NZ_LZQS01000001.1 Lassopeptides: STIB_RS37415_lassopeptide NZ_RCOL01000001.1 Lassopeptides: STAN_RS20170_lassopeptide NZ_VEHK01000003.1 Lassopeptides: FS984_RS09665_lassopeptide NZ_WUEJ01000001.1 Lassopeptides: GRQ63_RS00790_lassopeptide NZ_WWGL01000031.1 Lassopeptides: GTY38_RS20560_lassopeptide
Lassopeptides: YUW_RS35360_lassopeptide
1
G Y F Y G S Y K E Y W V R R I I
16
G Y F Y G S Y K E Y W V R R I I
1
G Y F Y G S Y K E Y W V R R I I
16
93.8%
NZ_CP110539.1 and 1 other:
NZ_CP112880.1 Lassopeptides: N7925_RS15605_lassopeptide
Lassopeptides: OH133_RS17115_lassopeptide
1
G Y F Y G S Y K E Y W V R R I
15
G Y F Y G S Y K E Y W V R R I
1
G Y F Y G S Y K E Y W V R R I
15
87.5%
NZ_BMRY01000001.1 and 14 others:
NZ_BMSZ01000030.1 Lassopeptides: IE135_RS32485_lassopeptide NZ_CP010833.1 Lassopeptides: TK78_RS35300_lassopeptide NZ_CP021707.1 Lassopeptides: CCZ36_RS19605_lassopeptide NZ_CP084357.1 Lassopeptides: LEL86_RS33655_lassopeptide NZ_DS999644.1 Lassopeptides: SSGG_RS36910_lassopeptide NZ_JNLT01000024.1 Lassopeptides: CD02_RS38355_lassopeptide NZ_KZ679082.1 Lassopeptides: C6W96_RS19995_lassopeptide NZ_KZ819154.1 Lassopeptides: DBP12_RS14735_lassopeptide NZ_KZ819178.1 Lassopeptides: DBP20_RS19850_lassopeptide NZ_KZ819182.1 Lassopeptides: DBP21_RS20195_lassopeptide NZ_LACR01000007.1 Lassopeptides: YW5_RS36195_lassopeptide NZ_LZRD01000023.1 Lassopeptides: A3Q37_RS36590_lassopeptide NZ_NNBN01000001.1 Lassopeptides: CG717_RS32755_lassopeptide NZ_WWGD01000017.1 Lassopeptides: GTY72_RS09250_lassopeptide
Lassopeptides: IE140_RS06105_lassopeptide
1
G Y F Y G S Y K E Y W V R R I I
16
G Y F G S Y K E Y W R R I I
1
G Y F V G S Y K E Y W S R R I I
16
with 12 more sequence matches
Only the first 10 are displayed here.
87.5%
NZ_CP013738.1 and 4 others:
NZ_CP029361.1 Lassopeptides: DIJ69_RS14415_lassopeptide NZ_CP090837.1 Lassopeptides: LZ559_RS19885_lassopeptide NZ_JAJUKK010000001.1 Lassopeptides: LXH09_RS00260_lassopeptide NZ_LIXK01000001.1 Lassopeptides: AMK23_RS36895_lassopeptide
Lassopeptides: WQO_RS35795_lassopeptide
1
G Y F Y G S Y K E Y W V R R I I
16
G Y F G S Y K E Y W R R I I
1
G Y F V G S Y K E Y W T R R I I
16
82.4%
NC_021177.1 and 5 others:
NZ_BMUG01000007.1 Lassopeptides: IE264_RS21365_lassopeptide NZ_CP054926.1 Lassopeptides: HUT09_RS19455_lassopeptide NZ_CP068598.1 Lassopeptides: IFE09_RS19740_lassopeptide NZ_CP071044.1 Lassopeptides: JHY03_RS19320_lassopeptide NZ_JOJC01000016.1 Lassopeptides: IO23_RS1000000136610_lassopeptide
Lassopeptides: SFUL_RS36235_lassopeptide
1
G Y F Y G S Y K E Y W V R R I I
16
G Y F G S Y K E Y W V R R I+
1
G Y F V G S Y K E Y W V R R I V
16
81.2%
NZ_BDHJ01000011.1 and 4 others:
NZ_BMTW01000001.1 Lassopeptides: IE134_RS04135_lassopeptide NZ_CP076457.1 Lassopeptides: KME66_RS14195_lassopeptide NZ_KZ268499.1 Lassopeptides: CE422_RS34520_lassopeptide NZ_ML123117.1 Lassopeptides: EES46_RS05210_lassopeptide
Lassopeptides: BHQ08_RS34645_lassopeptide
1
G Y F Y G S Y K E Y W V R R I I
16
G Y F G S Y K E Y W R R I+
1
G Y F V G S Y K E Y W T R R I V
16
81.2%
NZ_CP020563.1:
Lassopeptides: B7C62_RS35255_lassopeptide
1
G Y F Y G S Y K E Y W V R R I I
16
G Y F G S Y K E+W R R I I
1
G Y F I G S Y K E F W S R R I I
16
75.0%
NZ_KB891808.1:
Lassopeptides: B072_RS47760_lassopeptide
1
G Y F Y G S Y K E Y W V R R I I
16
G Y F G S Y K E+ V R R I+
1
G Y F V G S Y K E W I V R R I V
16
75.0%
NZ_PGGW01000069.1:
Lassopeptides: CUT44_RS32610_lassopeptide
1
G Y F Y G S Y K E Y W V R R I I
16
G Y F Y G S Y K E+ R R I+
1
G Y F Y G S Y K E F L S R R I V
16
68.8%
NZ_CP061281.1:
Lassopeptides: IAG42_RS10065_lassopeptide
1
G Y F Y G S Y K E Y W V R R I I
16
G Y F G Y K E+ V R R I+
1
G Y F V G P Y K E W I V R R I V
16
62.5%
NZ_FOET01000001.1:
Lassopeptides: BMY40_RS27365_lassopeptide
1
G Y F Y G S Y K E Y W V R R I I
16
G Y F G Y K E Y+ R R +
1
G Y F V G K Y K E Y F S R R F V
16
62.5%
NZ_FOSG01000008.1 and 1 other:
NZ_PDKQ02000012.1 Lassopeptides: BFM75_RS03245_lassopeptide
Lassopeptides: BM237_RS28735_lassopeptide
1
G Y F Y G S Y K E Y W V R R I I
16
G Y F+G Y K E Y+ R R +
1
G Y F F G K Y K E Y F S R R F V
16
58.8%
NZ_JACHEM010000013.1:
Lassopeptides: HNQ79_RS23595_lassopeptide
1
G Y F Y G S Y K E Y W V R R I I
16
G F Y S K E Y W R R+
1
G M F Y A S C K E Y W S R R L C
16

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.39 out of 19.26
Confidence: strong
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 22.05 out of 22.40
Confidence: strong
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.13 out of 19.26
Confidence: medium
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 23.00 out of 27.04
Confidence: medium
Additional weak hits (20):
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.17 out of 26.85
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.98 out of 28.14
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.09 out of 30.25
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.11 out of 29.38
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.70 out of 29.38
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.60 out of 30.22
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.59 out of 39.62
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.51 out of 27.78
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 18.16 out of 31.73
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 16.65 out of 31.73
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.34 out of 30.22
Confidence: weak
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.60 out of 21.84
Confidence: weak
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.52 out of 20.97
Confidence: weak
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.03 out of 19.26
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.93 out of 28.19
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 18.90 out of 35.63
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 23.25 out of 36.53
Confidence: weak
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.56 out of 24.78
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.33 out of 32.93
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.77 out of 28.19
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Lasso peptides
NRPS/PKS products
NRPS/PKS substrates
RREFinder
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of disulfide bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

MQC87_RS04740 - Class II
  Cleavage pHMM score: 0.20
  RODEO score: 20
  Monoisotopic mass: 2081.0 Da
  Molecular weight: 2082.4 Da
  Number of bridges: 0

Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 31496 - 90009:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (D-X - Val) + (emal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 54097 - 90009:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (D-X - Val) + (emal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 66887 - 90009:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (D-X - Val) + (emal)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
MQC87_RS04885: X - Val
Search NORINE for peptide: strict or relaxed
AMP-binding (26..428): X
nrpys: Gly, Ala, Val, Leu, Ile, Abu, Ival

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LEAAFDMSVWDATLVIGGEINAYGPTESTVWATF
  Nearest Stachelhaus code(s):
    Phe DAWTVAAVCK (71% 8Å match)
  Stachelhaus code match:
    70% (weak)

AMP-binding (1851..2257): Val
nrpys: Val

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LSTHFDFSVWEGNQVFGGEVNMYGITETTVHVTF
  Nearest Stachelhaus code(s):
    Val DFWNVGMVHK (97% 8Å match)
    Thr DFWNVGMVHK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

MQC87_RS04905: emal
PKS_AT (330..626): emal
ATSignature: Isobutyryl-CoA, Methylmalonyl-CoA, Ethylmalonyl-CoA

Top 3 matches:
  Isobutyryl-CoA: 79.2%
  Methylmalonyl-CoA: 79.2%
  Ethylmalonyl-CoA: 79.2%

minowa: Ethylmalonyl-CoA

Prediction, score:
  Ethylmalonyl-CoA: 170.4
  Methylmalonyl-CoA: 169.9
  2-Methylbutyryl-CoA: 154.2
  Methoxymalonyl-CoA: 138.2
  Propionyl-CoA: 115.1
  trans-1,2-CPDA: 111.7
  CHC-CoA: 86.8
  Malonyl-CoA: 73.7
  Benzoyl-CoA: 50.0
  Isobutyryl-CoA: 47.3
  3-Methylbutyryl-CoA: 27.9
  fatty_acid: 15.0
  Acetyl-CoA: 13.3
  inactive: 10.5

Link to PARAS substrate predictor
RRE predictions
RREfinder results sidepanel.

lassopeptide protocluster (31496...54161)
MQC87_RS04730
  RRE type: Stand_Alone_Lasso_RRE
  Location: 0 - 82
  Score: 83.4

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsR | Pleiotropic regulatory for antibiotic production
CRP | Cyclic AMP receptor protein
DasR | N-acetylglucosamine dependent repressor
HypR | L-hydroxyproline utilization repressor

NZ_JALDPQ010000045.1 - Region 1 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 69,380 - 90,456 nt. (total: 21,077 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
MQC87_RS06060: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

Transferases: formyltransferase
MQC87_RS06030: methionyl-tRNA formyltransferase

smcogs
  SMCOG1228: methionyl-tRNA formyltransferase

Lyases: cyclase hydratase
MQC87_RS06050: Terpene synthase/cyclase metal-binding domain protein

smcogs
  SMCOG1052: Terpene synthase/cyclase metal-binding domain protein

MQC87_RS06070: Nitrilase/cyanide hydratase and apolipoprotein

smcogs
  SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002708.2 |  | 0.75 | terpene | (+)-δ-cadinol | Coniophora puteana RWD-64-598 SS2
BGC0002707.2 |  | 0.47 | terpene | (+)-δ-cadinol | Coniophora puteana RWD-64-598 SS2
BGC0000631.5 |  | 0.37 | terpene | Botrydial, 8,9-epibotrydial, 1-epibotrydial, Dihydrobotrydial, 10-Oxo-dihydrobotrydial, 10-dehydroxy dihydrobotrydialone, 10-epi-dihydrobotrydial, Botryendial, Botryenalol, Botrydienal, Norbotrydialone acetate, 10-Oxodihydrobotry-1(9),4(5)-diendial, 10-Oxodehydrodihydrobotrydial, Dehydrobotrydienol, 11-Hydroxydehydrobotrydienol, 12-hydroxydehydrobotrydienol, Secobotrytriendiol, Secobotrytriene-10,12,15-triol, Secobotrydiene-3,10,15-triol, Secobotrydiene-3,4,10,15-tetraol, 4β-Acetoxytetrahydrobotryslactone | Botrytis cinerea B05.10
BGC0002034.3 |  | 0.36 | other (other) | perquinoline A, perquinoline B, perquinoline C | Streptomyces sp. IB2014 016-6
BGC0000879.5 |  | 0.35 | other (other) | toyocamycin, sangivamycin | Streptomyces rimosus
BGC0001677.3 |  | 0.35 | PKS | mycophenolic acid | Penicillium roqueforti
BGC0002616.2 |  | 0.35 | PKS | mycophenolic acid | Penicillium roqueforti
BGC0001360.3 |  | 0.34 | PKS | mycophenolic acid | Penicillium roqueforti FM164
BGC0002619.2 |  | 0.34 | PKS | mycophenolic acid | Penicillium brevicompactum
BGC0000881.3 |  | 0.33 | other (other) | toyocamycin | Streptomyces ahygroscopicus subsp. wuzhouensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002708.2 |  | 0.75 | terpene | (+)-δ-cadinol | Coniophora puteana RWD-64-598 SS2
BGC0002707.2 |  | 0.47 | terpene | (+)-δ-cadinol | Coniophora puteana RWD-64-598 SS2
BGC0000631.5 |  | 0.37 | terpene | Botrydial, 8,9-epibotrydial, 1-epibotrydial, Dihydrobotrydial, 10-Oxo-dihydrobotrydial, 10-dehydroxy dihydrobotrydialone, 10-epi-dihydrobotrydial, Botryendial, Botryenalol, Botrydienal, Norbotrydialone acetate, 10-Oxodihydrobotry-1(9),4(5)-diendial, 10-Oxodehydrodihydrobotrydial, Dehydrobotrydienol, 11-Hydroxydehydrobotrydienol, 12-hydroxydehydrobotrydienol, Secobotrytriendiol, Secobotrytriene-10,12,15-triol, Secobotrydiene-3,10,15-triol, Secobotrydiene-3,4,10,15-tetraol, 4β-Acetoxytetrahydrobotryslactone | Botrytis cinerea B05.10
BGC0002034.3 |  | 0.36 | other (other) | perquinoline A, perquinoline B, perquinoline C | Streptomyces sp. IB2014 016-6
BGC0000879.5 |  | 0.35 | other (other) | toyocamycin, sangivamycin | Streptomyces rimosus
BGC0001677.3 |  | 0.35 | PKS | mycophenolic acid | Penicillium roqueforti
BGC0002616.2 |  | 0.35 | PKS | mycophenolic acid | Penicillium roqueforti
BGC0001360.3 |  | 0.34 | PKS | mycophenolic acid | Penicillium roqueforti FM164
BGC0002619.2 |  | 0.34 | PKS | mycophenolic acid | Penicillium brevicompactum
BGC0000881.3 |  | 0.33 | other (other) | toyocamycin | Streptomyces ahygroscopicus subsp. wuzhouensis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
monoterpene |  |  | C10 | C1-C10 | none
sesquiterpene |  |  | C15 | C1-C10 | none

Genes with terpene domains:
MQC87_RS06050: T1TS
Domain 1 (4 - 315): Type 1 terpene synthase
Subtype: Germacrene A synthase type

Reactions:
  GPP → monoterpene_C1-C10
  FPP → sesquiterpene_C1-C10

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16
Confidence: strong
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.10 out of 23.79
Confidence: medium
Additional weak hits (24):
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 19.00 out of 27.55
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.66 out of 26.06
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.43 out of 39.62
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 16.37 out of 26.12
Confidence: weak
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.21 out of 26.33
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.70 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.15 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.18 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 16.76 out of 26.06
Confidence: weak
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.15 out of 18.57
Confidence: weak
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.23 out of 20.97
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.14 out of 26.06
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 15.93 out of 31.73
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.08 out of 26.06
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 16.62 out of 31.73
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.01 out of 28.14
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 18.48 out of 28.14
Confidence: weak
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.92 out of 26.33
Confidence: weak
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.67 out of 26.33
Confidence: weak
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.84 out of 26.33
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.72 out of 28.19
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.24 out of 28.19
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.90 out of 28.19
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.45 out of 28.19
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
FPP | Farnesyl diphosphate
GPP | Geranyl diphoshate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
IolR | Regulator of the inositol catabolism

NZ_JALDPQ010000047.1 - Region 1 - NRPS,T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,476 - 50,853 nt. (total: 49,378 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase oxygenase
MQC87_RS07435: cytochrome P450

smcogs
  SMCOG1007: cytochrome P450

MQC87_RS07440: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs
  SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

MQC87_RS07445: dehydrogenase

smcogs
  SMCOG1222: dehydrogenase

MQC87_RS07450: dehydrogenase

smcogs
  SMCOG1222: dehydrogenase

MQC87_RS07510: NADH:flavin oxidoreductase/NADH oxidase

smcogs
  SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

MQC87_RS07535: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: aminotransferase
MQC87_RS07465: aminotransferase class V

smcogs
  SMCOG1139: aminotransferase class V

Hydrolases: hydrolase
MQC87_RS07430: alpha/beta hydrolase domain-containing protein

smcogs
  SMCOG1066: alpha/beta hydrolase domain-containing protein

Isomerases: racemase
MQC87_RS07390: mandelate racemase/muconate lactonizing enzyme

smcogs
  SMCOG1268: mandelate racemase/muconate lactonizing enzyme

Ligases: synthase
MQC87_RS07455: Beta-ketoacyl synthase

smcogs
  SMCOG1093: Beta-ketoacyl synthase

Translocases: transport
MQC87_RS07495: MMPL domain-containing transport protein

smcogs
  SMCOG1035: MMPL domain-containing transport protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | T1PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001043.4 |  |  | 1.39 | NRPS, PKS | SGR PTMs, SGR PTM Compound b, SGR PTM Compound c, SGR PTM Compound d | Streptomyces griseus subsp. griseus NBRC 13350
BGC0002365.2 |  |  | 1.30 | PKS, other (other) | 10-epi-HSAF, 10-epi-3-deOH-HSAF, 10-epi-maltophilin, 10-epi-xanthobaccin C, 10-epi-hydroxymaltophilin, 10-epi-FI-2 | Streptomyces sp.
BGC0001275.3 |  |  | 0.90 | PKS | 6-methylsalicyclic acid | Glarea lozoyensis
BGC0001273.3 |  |  | 0.90 | PKS | asperlactone | Aspergillus ochraceus
BGC0001244.3 |  |  | 0.90 | PKS | (-)-Mellein | Parastagonospora nodorum
BGC0000996.5 |  |  | 0.89 | NRPS, PKS | frontalamide B, frontalamide A | Streptomyces sp. SPB78
BGC0001726.4 |  |  | 0.75 | NRPS, PKS | pactamide A, pactamide B, pactamide C, pactamide D, pactamide E, pactamide F | Streptomyces pactum
BGC0002509.3 |  |  | 0.72 | NRPS | montamide A, capsimycin, clifednamide A, frontalamide A, combamide A | Streptomyces sp.
BGC0001132.4 |  |  | 0.68 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  |  | 0.68 | NRPS | icosalide A, icosalide B | Burkholderia gladioli

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001043.4 |  | 0.89 | NRPS, PKS | SGR PTMs, SGR PTM Compound b, SGR PTM Compound c, SGR PTM Compound d | Streptomyces griseus subsp. griseus NBRC 13350
BGC0002365.2 |  | 0.86 | PKS, other (other) | 10-epi-HSAF, 10-epi-3-deOH-HSAF, 10-epi-maltophilin, 10-epi-xanthobaccin C, 10-epi-hydroxymaltophilin, 10-epi-FI-2 | Streptomyces sp.
BGC0001275.3 |  | 0.75 | PKS | 6-methylsalicyclic acid | Glarea lozoyensis
BGC0001273.3 |  | 0.75 | PKS | asperlactone | Aspergillus ochraceus
BGC0001244.3 |  | 0.75 | PKS | (-)-Mellein | Parastagonospora nodorum
BGC0000996.5 |  | 0.75 | NRPS, PKS | frontalamide B, frontalamide A | Streptomyces sp. SPB78
BGC0001726.4 |  | 0.70 | NRPS, PKS | pactamide A, pactamide B, pactamide C, pactamide D, pactamide E, pactamide F | Streptomyces pactum
BGC0002509.3 |  | 0.69 | NRPS | montamide A, capsimycin, clifednamide A, frontalamide A, combamide A | Streptomyces sp.
BGC0001132.4 |  | 0.67 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  | 0.67 | NRPS | icosalide A, icosalide B | Burkholderia gladioli

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.09 out of 20.47
Confidence: medium
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 24.84 out of 29.72
Confidence: medium
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 28.35 out of 35.63
Confidence: medium
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 23.25 out of 29.72
Confidence: medium
Additional weak hits (7):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.32 out of 26.06
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.06 out of 29.38
Confidence: weak
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.92 out of 26.33
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 19.81 out of 30.98
Confidence: weak
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 14.29 out of 18.57
Confidence: weak
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 18.82 out of 25.88
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.01 out of 28.19
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 1475 - 50853:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (pk - Orn)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
MQC87_RS07455: pk - Orn
Search NORINE for peptide: strict or relaxed
PKS_AT (548..844): pk
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 70.8%
  Methylmalonyl-CoA: 58.3%
  CE-Malonyl-CoA: 54.2%

minowa: Methylmalonyl-CoA

Prediction, score:
  Methylmalonyl-CoA: 130.6
  Methoxymalonyl-CoA: 121.6
  Malonyl-CoA: 118.3
  Ethylmalonyl-CoA: 108.2
  Isobutyryl-CoA: 92.4
  Acetyl-CoA: 75.1
  Propionyl-CoA: 68.3
  2-Methylbutyryl-CoA: 68.0
  trans-1,2-CPDA: 67.8
  Benzoyl-CoA: 59.8
  CHC-CoA: 49.5
  fatty_acid: 43.0
  3-Methylbutyryl-CoA: 39.1
  inactive: 34.0

AMP-binding (2298..2712): Orn
nrpys: Orn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Long positively charged side chain (Orn, Lys, Arg)
  Small clusters prediction:
    Orn and hydroxy-Orn specific (Orn, OH-Orn)
  Single AA prediction:
    orn (Orn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    AAWAFDVFTGDREFVVGSDVNSYGLTEATIDSAY
  Nearest Stachelhaus code(s):
    Orn DVGEVGSIDK (85% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
NrtR | NAD synthesis repressor
NtrC | Nitrogen regulatory protein C
VqsM | Regulator of quorum-sensing signalling systems

NZ_JALDPQ010000047.1 - Region 2 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 106,088 - 132,651 nt. (total: 26,564 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
MQC87_RS07935: dehydrogenase

smcogs
  SMCOG1181: dehydrogenase

Transferases: aminotransferase transferase
MQC87_RS07875: aminotransferase class-III

smcogs
  SMCOG1013: aminotransferase class-III

MQC87_RS07940: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs
  SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

Lyases: dehydratase
MQC87_RS07950: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthetase
MQC87_RS07895: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000663.5 |  | 0.69 | terpene | hopene | Streptomyces coelicolor A3(2)
BGC0000647.3 |  | 0.57 | terpene | carotenoid | Rhodobacter sphaeroides
BGC0000656.5 |  | 0.50 | terpene | zeaxanthin | Xanthobacter autotrophicus Py2
BGC0002162.3 |  | 0.49 | terpene | sesterfisherol, sesterfisheric acid, compound 6, compound 7a, compound 5, compound 8 | Aspergillus fischeri NRRL 181
BGC0002610.3 |  | 0.49 | terpene | stellatic acid | Aspergillus stellatus
BGC0000630.3 |  | 0.49 | terpene | (2R,3S,3'S)-2-hydroxyastaxanthin | Paracoccus haeundaensis
BGC0000646.5 |  | 0.49 | terpene | β-carotein | uncultured bacterium
BGC0002173.2 |  | 0.48 | saccharide, terpene | fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol | Aspergillus fumigatus A1163
BGC0000640.3 |  | 0.48 | terpene | carotenoid | Enterobacteriaceae bacterium DC404
BGC0002508.2 |  | 0.48 | other (other) | 8-azaguanine | Streptomyces pathocidini

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000663.5 |  | 0.69 | terpene | hopene | Streptomyces coelicolor A3(2)
BGC0000647.3 |  | 0.57 | terpene | carotenoid | Rhodobacter sphaeroides
BGC0000656.5 |  | 0.50 | terpene | zeaxanthin | Xanthobacter autotrophicus Py2
BGC0002162.3 |  | 0.49 | terpene | sesterfisherol, sesterfisheric acid, compound 6, compound 7a, compound 5, compound 8 | Aspergillus fischeri NRRL 181
BGC0002610.3 |  | 0.49 | terpene | stellatic acid | Aspergillus stellatus
BGC0000630.3 |  | 0.49 | terpene | (2R,3S,3'S)-2-hydroxyastaxanthin | Paracoccus haeundaensis
BGC0000646.5 |  | 0.49 | terpene | β-carotein | uncultured bacterium
BGC0002173.2 |  | 0.48 | saccharide, terpene | fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol | Aspergillus fumigatus A1163
BGC0000640.3 |  | 0.48 | terpene | carotenoid | Enterobacteriaceae bacterium DC404
BGC0002508.2 |  | 0.48 | other (other) | 8-azaguanine | Streptomyces pathocidini

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene | hopanoid |  | C30 | hopanoid skeleton | unknown
triterpene | polypodane |  | C30 | polypodane skeleton | unknown

Genes with terpene domains:
MQC87_RS07890: T2TS
Domain 1 (25 - 652): Type 2 terpene synthase
Subtype: Squalene substrate

Reactions:
  squalene → hopanoid
  squalene → polypodane

MQC87_RS07895: PT_FPPS_like
Domain 1 (74 - 366): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: unknown

Reactions:
  IPP, DMAPP → FPP
  IPP, DMAPP → GGPP
  IPP, DMAPP → GFPP
  IPP, DMAPP → HPP

MQC87_RS07905: PT_phytoene_like
Domain 1 (13 - 296): Prenyltransferase; Phytoene synthase like
Subtype: unknown

Reactions:
  FPP → PSPP
  FPP → squalene
  FPP → diapophytoene
  GGPP → phytoene
  PSPP → hydroxysqualene

MQC87_RS07910: PT_phytoene_like
Domain 1 (16 - 284): Prenyltransferase; Phytoene synthase like
Subtype: Hydroxysqualene synthase

Reactions:
  PSPP → hydroxysqualene

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.09 out of 23.79
Confidence: medium
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 19.02 out of 21.84
Confidence: medium
Additional weak hits (10):
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 20.52 out of 32.74
Confidence: weak
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.38 out of 26.85
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.37 out of 27.78
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.81 out of 27.78
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.92 out of 30.22
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.59 out of 29.38
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.23 out of 30.98
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.72 out of 28.19
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.04 out of 29.65
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 21.29 out of 36.53
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
GFPP | Geranylfarnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
HPP | Hexaprenyl diphosphate
IPP | Isopentenyl diphosphate
PSPP | Presqualene diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
IolR | Regulator of the inositol catabolism
MexT | Global virulence regulator

NZ_JALDPQ010000049.1 - Region 1 - T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 4,284 nt. (total: 4,284 nt) Show pHMM detection rules used
Region on contig edge.
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: acylase
MQC87_RS09300: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T1PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000122.5 |  | 0.49 | PKS | phenylnannolone A, phenylnannolone B, phenylnannolone C | Nannocystis pusilla
BGC0000353.5 |  | 0.47 | NRPS | tacrolimus | Streptomyces sp. MA6548
BGC0000041.3 |  | 0.47 | PKS | oronofacic acid | Pseudomonas syringae
BGC0002138.2 |  | 0.46 | PKS | fuelimycin A, fuelimicin B, fuelimicin C | Streptomyces albireticuli NRRL B-1670
BGC0001544.3 |  | 0.45 | NRPS, PKS | chlorflavonin | Aspergillus campestris IBT 28561
BGC0001235.4 |  | 0.44 | NRPS, PKS | antalid | Polyangium spumosum
BGC0000067.5 |  | 0.42 | PKS | geldanamycin | Streptomyces hygroscopicus subsp. duamyceticus
BGC0000143.5 |  | 0.40 | PKS | salinomycin | Streptomyces albus
BGC0001647.3 |  | 0.40 | PKS | lagunapyrone A, lagunapyrone B, lagunapyrone C | Streptomyces sp. MP131-18
BGC0000999.4 |  | 0.40 | NRPS, PKS | heat-stable antifungal factor | Lysobacter enzymogenes

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000122.5 |  | 0.49 | PKS | phenylnannolone A, phenylnannolone B, phenylnannolone C | Nannocystis pusilla
BGC0000353.5 |  | 0.47 | NRPS | tacrolimus | Streptomyces sp. MA6548
BGC0000041.3 |  | 0.47 | PKS | oronofacic acid | Pseudomonas syringae
BGC0002138.2 |  | 0.46 | PKS | fuelimycin A, fuelimicin B, fuelimicin C | Streptomyces albireticuli NRRL B-1670
BGC0001544.3 |  | 0.45 | NRPS, PKS | chlorflavonin | Aspergillus campestris IBT 28561
BGC0001235.4 |  | 0.44 | NRPS, PKS | antalid | Polyangium spumosum
BGC0000067.5 |  | 0.42 | PKS | geldanamycin | Streptomyces hygroscopicus subsp. duamyceticus
BGC0000143.5 |  | 0.40 | PKS | salinomycin | Streptomyces albus
BGC0001647.3 |  | 0.40 | PKS | lagunapyrone A, lagunapyrone B, lagunapyrone C | Streptomyces sp. MP131-18
BGC0000999.4 |  | 0.40 | NRPS, PKS | heat-stable antifungal factor | Lysobacter enzymogenes

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 4284:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (ccmal)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
MQC87_RS09300: mal
PKS_AT (0..221): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 66.7%
  inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 158.2
  inactive: 84.8
  Methoxymalonyl-CoA: 74.7
  Methylmalonyl-CoA: 59.5
  Isobutyryl-CoA: 26.3
  Propionyl-CoA: 26.2
  Ethylmalonyl-CoA: 24.5
  2-Methylbutyryl-CoA: 24.4
  Acetyl-CoA: 13.3
  Benzoyl-CoA: 12.1
  fatty_acid: 10.5
  trans-1,2-CPDA: 10.4
  CHC-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor
NZ_JALDPQ010000052.1 - Region 1 - NRPS,T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 78,717 - 131,271 nt. (total: 52,555 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase oxygenase
MQC87_RS09740: cytochrome P450

smcogs
  SMCOG1007: cytochrome P450

MQC87_RS09795: aldo/keto reductase family oxidoreductase

smcogs
  SMCOG1039: aldo/keto reductase family oxidoreductase

MQC87_RS09860: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

MQC87_RS09880: dehydrogenase

smcogs
  SMCOG1072: dehydrogenase

Hydrolases: hydrolase
MQC87_RS09875: HAD-superfamily hydrolase, subfamily IA, variant

smcogs
  SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

Ligases: synthase
MQC87_RS09830: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

Translocases: transporter
MQC87_RS09895: sugar-binding lipoprotein

smcogs
  SMCOG1143: sugar-binding lipoprotein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | T1PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000307.4 |  |  | 0.61 | NRPS | AbT1 | Aureobasidium pullulans
BGC0001758.4 |  |  | 0.59 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001641.4 |  |  | 0.57 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002276.2 |  |  | 0.54 | NRPS | choline | Aspergillus nidulans FGSC A4
BGC0001160.5 |  |  | 0.53 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0001164.3 |  |  | 0.53 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0002099.3 |  |  | 0.47 | ribosomal | biarylitide YFH | Planomonospora sp. ID107089
BGC0002084.4 |  |  | 0.47 | ribosomal | biarylitide YYH | Planomonospora sp. ID82291
BGC0002631.2 |  |  | 0.41 | ribosomal | Myxarylin | Pyxidicoccus fallax
BGC0002518.3 |  |  | 0.37 | NRPS | syringafactin A, syringafactin C | Pseudomonas sp. SZ57

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000307.4 |  | 0.64 | NRPS | AbT1 | Aureobasidium pullulans
BGC0001758.4 |  | 0.63 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001641.4 |  | 0.62 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002276.2 |  | 0.61 | NRPS | choline | Aspergillus nidulans FGSC A4
BGC0001160.5 |  | 0.60 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0001164.3 |  | 0.60 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0002099.3 |  | 0.57 | ribosomal | biarylitide YFH | Planomonospora sp. ID107089
BGC0002084.4 |  | 0.57 | ribosomal | biarylitide YYH | Planomonospora sp. ID82291
BGC0002631.2 |  | 0.53 | ribosomal | Myxarylin | Pyxidicoccus fallax
BGC0002518.3 |  | 0.50 | NRPS | syringafactin A, syringafactin C | Pseudomonas sp. SZ57

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.94 out of 20.01
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.31 out of 23.79
Confidence: medium
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 26.90 out of 30.12
Confidence: medium
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.92 out of 20.47
Confidence: medium
Additional weak hits (12):
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 14.96 out of 27.78
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.49 out of 39.62
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.63 out of 27.78
Confidence: weak
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.47 out of 26.33
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 24.13 out of 30.22
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.68 out of 32.93
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 20.01 out of 35.63
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.53 out of 28.14
Confidence: weak
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.59 out of 22.40
Confidence: weak
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.07 out of 21.84
Confidence: weak
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 16.64 out of 21.84
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.96 out of 32.93
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 78716 - 131271:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (NH2 - ohmal - X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
MQC87_RS09830: NH2 - mal - X
CAL_domain (122..451): NH2
minowa: NH2

Prediction, score:
  NH2: 43.7
  fatty_acid: 36.4
  shikimic_acid: 0.0
  Acetyl-CoA: 0.0
  AHBA: 0.0

PKS_AT (1239..1521): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 79.2%
  inactive: 66.7%
  Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 124.3
  Methylmalonyl-CoA: 73.2
  Methoxymalonyl-CoA: 68.5
  inactive: 52.1
  Propionyl-CoA: 40.9
  fatty_acid: 35.0
  Ethylmalonyl-CoA: 31.7
  2-Methylbutyryl-CoA: 29.4
  Isobutyryl-CoA: 28.8
  trans-1,2-CPDA: 24.1
  CHC-CoA: 17.7
  Acetyl-CoA: 13.6
  Benzoyl-CoA: 11.1
  3-Methylbutyryl-CoA: 0.0

AMP-binding (2704..3124): X
nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWAAFDASVRQASSHVGGEANLYGPTEATINTSC
  Nearest Stachelhaus code(s):
    Gln DACSTGVINK (50% 8Å match)
  Stachelhaus code match:
    70% (weak)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArgR | Regulator of arginine biosynthesis genes
IolR | Regulator of the inositol catabolism
OsdR | Development and stress management regulator
VqsM | Regulator of quorum-sensing signalling systems

NZ_JALDPQ010000054.1 - Region 1 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 18,111 nt. (total: 18,111 nt) Show pHMM detection rules used
Region on contig edge.
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxygenase
MQC87_RS10520: cytochrome P450

smcogs
  SMCOG1007: cytochrome P450

Transferases: PPTase transferase
MQC87_RS10460: acetyl-CoA carboxylase, carboxyl transferase,

smcogs
  SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

MQC87_RS10465: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

Ligases: synthetase
MQC87_RS10490: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002631.2 |  | 0.54 | ribosomal | Myxarylin | Pyxidicoccus fallax
BGC0000902.4 |  | 0.46 | PKS | flaviolin | Saccharopolyspora erythraea NRRL 2338
BGC0000844.5 |  | 0.46 | other (other) | clavulanic acid | Streptomyces clavuligerus
BGC0000677.5 |  | 0.46 | terpene | cyclooctatin | Streptomyces melanosporofaciens
BGC0001224.5 |  | 0.45 | other (other) | reductasporine | uncultured bacterium
BGC0002031.3 |  | 0.44 | other (other) | kitasetaline | Kitasatospora setae KM-6054
BGC0000528.5 |  | 0.43 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001910.4 |  | 0.42 | terpene | cyslabdan A, cyslabdan B, cyslabdan C | Streptomyces cyslabdanicus
BGC0001911.3 |  | 0.41 | terpene | raimonol | Streptomyces anulatus
BGC0000285.5 |  | 0.41 | PKS, saccharide | flaviolin, flaviolin rhamnoside, 3,3'-diflaviolin | Saccharopolyspora erythraea

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002631.2 |  | 0.54 | ribosomal | Myxarylin | Pyxidicoccus fallax
BGC0000902.4 |  | 0.46 | PKS | flaviolin | Saccharopolyspora erythraea NRRL 2338
BGC0000844.5 |  | 0.46 | other (other) | clavulanic acid | Streptomyces clavuligerus
BGC0000677.5 |  | 0.46 | terpene | cyclooctatin | Streptomyces melanosporofaciens
BGC0001224.5 |  | 0.45 | other (other) | reductasporine | uncultured bacterium
BGC0002031.3 |  | 0.44 | other (other) | kitasetaline | Kitasatospora setae KM-6054
BGC0000528.5 |  | 0.43 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001910.4 |  | 0.42 | terpene | cyslabdan A, cyslabdan B, cyslabdan C | Streptomyces cyslabdanicus
BGC0001911.3 |  | 0.41 | terpene | raimonol | Streptomyces anulatus
BGC0000285.5 |  | 0.41 | PKS, saccharide | flaviolin, flaviolin rhamnoside, 3,3'-diflaviolin | Saccharopolyspora erythraea

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP
diterpene precursor |  | GGPP | C20 | acyclic | PP
sesterterpene precursor |  | GFPP | C25 | acyclic | PP
triterpene precursor |  | HPP | C30 | acyclic | PP

Genes with terpene domains:
MQC87_RS10490: PT_FPPS_like
Domain 1 (46 - 348): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: unknown

Reactions:
  IPP, DMAPP → FPP
  IPP, DMAPP → GGPP
  IPP, DMAPP → GFPP
  IPP, DMAPP → HPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 22.22 out of 27.04
Confidence: medium
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 22.24 out of 27.04
Confidence: medium
Additional weak hits (3):
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.06 out of 26.33
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.42 out of 29.65
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 22.96 out of 30.11
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
GFPP | Geranylfarnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
HPP | Hexaprenyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
DasR | N-acetylglucosamine dependent repressor

NZ_JALDPQ010000054.1 - Region 2 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 106,662 - 132,962 nt. (total: 26,301 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
MQC87_RS10985: NADH:flavin oxidoreductase/NADH oxidase

smcogs
  SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

Lyases: cyclase hydratase
MQC87_RS11010: Nitrilase/cyanide hydratase and apolipoprotein

smcogs
  SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein

MQC87_RS11025: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

MQC87_RS11035: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001229.4 |  | 0.61 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000554.4 |  | 0.56 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0002110.3 |  | 0.55 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0000528.5 |  | 0.55 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0002346.3 |  | 0.54 | ribosomal | kyamicin | Saccharopolyspora sp.
BGC0000525.5 |  | 0.53 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0001311.5 |  | 0.52 | ribosomal | flavecins | Ruminococcus flavefaciens FD-1
BGC0000517.4 |  | 0.52 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0001391.3 |  | 0.51 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni
BGC0000552.3 |  | 0.50 | ribosomal | SmbA, SmbB | Streptococcus mutans

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001229.4 |  | 0.61 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000554.4 |  | 0.56 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0002110.3 |  | 0.55 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0000528.5 |  | 0.55 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0002346.3 |  | 0.54 | ribosomal | kyamicin | Saccharopolyspora sp.
BGC0000525.5 |  | 0.53 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0001311.5 |  | 0.52 | ribosomal | flavecins | Ruminococcus flavefaciens FD-1
BGC0000517.4 |  | 0.52 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0001391.3 |  | 0.51 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni
BGC0000552.3 |  | 0.50 | ribosomal | SmbA, SmbB | Streptococcus mutans

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for MQC87_RS11025

MQC87_RS11020
Leader:
MANPNVGILEEIDDQNLDAVSAA
Core:
G Q G W G T I V S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C K
Core with dehydrations:
G Q G W G Dhb I V Dha Dha L Dha Cys Y G A Dha Y V L G N N G N F Cys Dhb A Dhb A E Cys Q N N Cys K

#### antiSMASH-DB 4.0 matches for MQC87_RS11020

100.0%
NZ_BMRY01000003.1 and 24 others:
NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12370_lanthipeptide NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptide NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptide NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptide NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptide NZ_CP021707.1 Lanthipeptides: CCZ36_RS18205_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide
Lanthipeptides: IE140_RS12370_lanthipeptide
1
G Q G W G T I V S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C K
38
G Q G W G T I V S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C K
1
G Q G W G T I V S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C K
38
94.7%
NZ_CP116355.1 and 1 other:
NZ_CP116355.1 Lanthipeptides: KPP03845_RS17815_lanthipeptide
Lanthipeptides: KPP03845_RS17815_lanthipeptide
1
G Q G W G T I V S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C K
38
G Q G W G T++S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C K
1
G Q G W G T V M S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C K
38
89.5%
NZ_WHOM01000078.1 and 1 other:
NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29300_lanthipeptide
Lanthipeptides: GCN81_RS29300_lanthipeptide
1
G Q G W G T I V S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C K
38
G Q G W G T +S S L S C Y G A S Y V L G N N G N F C T A T A E C Q+N C+
1
G Q G W G T T L S S L S C Y G A S Y V L G N N G N F C T A T A E C Q S N C Q
38
with 112 more sequence matches
Only the first 10 are displayed here.
71.1%
NZ_QKTG01000020.1 and 1 other:
NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS16920_lanthipeptide
Lanthipeptides: DEI99_RS16920_lanthipeptide
2
Q G W G T I V S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C K
38
Q G G T V++L S C Y G S+ L G N+G N F C T A T E C Q+N C K
1
Q G I G T T V T T L S C Y G V S W A L G N D G N F C T A T V E C Q S N C K
37
66.7%
NZ_JALGRP010000007.1 and 1 other:
NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12955_lanthipeptide
Lanthipeptides: MT347_RS12955_lanthipeptide
1
G Q G W G T I V S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C
37
G Q G W T ++S L+C Y G S+V G N N G C T A T E C Q N N C
2
G Q G W T T T I T S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C
38
55.3%
NZ_LT575476.1 and 1 other:
NZ_LT575476.1 Lanthipeptides: BN6628_RS02285_lanthipeptide
Lanthipeptides: BN6628_RS02285_lanthipeptide
4
W G T I V S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C K
38
W G T++++L+C G A S Y L G+ G C T A T E C N N C+
3
W G T V L T T L A C L G A S Y A L G D K G Q V C T A T V E C I N N C R
37
52.6%
NZ_BCEY01000006.1 and 1 other:
NZ_BCEY01000006.1 Lanthipeptides: GOZ53_RS01290_lanthipeptide
Lanthipeptides: GOZ53_RS01290_lanthipeptide
3
G W-G T I V S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C K
38
G W G S +S C S+ L G N+G C T T A E C Q C K
1
G W T G V A K S I V S C S L I S F A L G N D G W I C T W T A E C Q A T C K
37
50.0%
NZ_JALIRS010000003.1 and 3 others:
NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07255_lanthipeptide NZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide NZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide
Lanthipeptides: MOK21_RS07255_lanthipeptide
2
Q G W G-T I V S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C
37
+ W T I++S L+C A S Y+L G N G+ C T T E C Q C
3
E R W A E T I L T S L A C A A A S Y I L G N P G H V C T L T V E C Q K K C
39
50.0%
NZ_JAQFWW010000002.1 and 1 other:
NZ_JAQFWW010000002.1 Lanthipeptides: PDT38_RS11330_lanthipeptide
Lanthipeptides: PDT38_RS11330_lanthipeptide
4
W G T I V S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C K
38
W G T++++L S C A S ++G+ G C T T E C Q N N C+
3
W G T L L T T L S C L A A S I M I G D K G Q V C T G T V E C Q N N C R
37
47.4%
NC_015215.1 and 5 others:
NC_015215.1 Lanthipeptides: SGGBAA2069_RS00705_lanthipeptide NZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09795_lanthipeptide NZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09795_lanthipeptide NZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05350_lanthipeptide NZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05350_lanthipeptide
Lanthipeptides: SGGBAA2069_RS00705_lanthipeptide
3
G W G T I V S S L-S C Y G A S Y V L G N N G N F C T A T A E C Q N N C K
38
G W + S+ S C S L G N+G C T T A E C Q C+
1
G W T G V A K S I T S C S L L S I G L G N D G W V C T W T A E C Q A T C R
37
47.4%
NC_017299.1 and 1 other:
NC_017299.1 Lanthipeptides: H04402_RS03105_lanthipeptide
Lanthipeptides: H04402_RS03105_lanthipeptide
5
G T I V S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C
37
G T I +L S Y +G N+G C T T E C Q N N C
5
G T I S I T L S V Y-----M G N D G K V C T W T V E C Q N N C
32
47.4%
NZ_WITJ01000001.1 and 1 other:
NZ_WITJ01000001.1 Lanthipeptides: GHI93_RS00065_lanthipeptide
Lanthipeptides: GHI93_RS00065_lanthipeptide
1
G Q G W G T I V S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C K
38
G W + S S+ + L G N N G C T T E C Q N C K
1
G W T W N L V F S S V----V T L A L G N N G Y V C T W T H E C Q A N C K
34
44.7%
NZ_BMVL01000013.1 and 1 other:
NZ_BMVL01000013.1 Lanthipeptides: IE257_RS28650_lanthipeptide
Lanthipeptides: IE257_RS28650_lanthipeptide
6
T I V S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C K
38
T I +++ A S+ L G N N G+ C T T E C Q N C+
1
T I F E T V T Y T V A S W A L G N N G H L C T V T V E C Q K N C Q
33

#### MIBiG 4.0 matches for MQC87_RS11020

36.8%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
14
Y G A S Y V L G N N G N F C T A T A E C Q N N C
37
+ S L G N N G +C T T E C Q N C
6
F S L S N A L G N N G G W C T L T K E C Q P N C
29
31.6%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
14
Y G A S Y V L G N N G N F C T A T A E C Q N N C
37
Y S L G N G +C T T E C +C
4
Y N I S C R L G N K G A Y C T L T V E C M P S C
27
17.9%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
27
C T A T A E C Q N N C
37
C T + E C Q N C
28
C T L S K E C Q P N C
38
MQC87_RS11030
Leader:
MGDIAMNDATGYVSADELVELADA
Core:
P E S L A A G F T P T I I P A T A V T T V I V G A S A A M Q G G C P T S G C T K R C
Core with dehydrations:
P E Dha L A A G F Dhb P Dhb I I P A Dhb A V Dhb Dhb V I V G A Dha A A M Q G G Cys P Dhb Dha G Cys Dhb K R Cys

#### antiSMASH-DB 4.0 matches for MQC87_RS11030

100.0%
NZ_BNBJ01000003.1 and 9 others:
NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05295_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19415_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19415_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11030_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11030_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32890_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32890_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100135_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100135_lanthipeptide
Lanthipeptides: IE304_RS05295_lanthipeptide
1
P E S L A A G F T P T I I P A T A V T T V I V G A S A A M Q G G C P T S G C T K R C
42
P E S L A A G F T P T I I P A T A V T T V I V G A S A A M Q G G C P T S G C T K R C
1
P E S L A A G F T P T I I P A T A V T T V I V G A S A A M Q G G C P T S G C T K R C
42
97.6%
NZ_BMRY01000003.1 and 9 others:
NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12360_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS34975_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS34975_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: CD02_RS0123035_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: CD02_RS0123035_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS18445_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS18445_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS03745_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS03745_lanthipeptide
Lanthipeptides: IE140_RS12360_lanthipeptide
1
P E S L A A G F T P T I I P A T A V T T V I V G A S A A M Q G G C P T S G C T K R C
42
P+S L A A G F T P T I I P A T A V T T V I V G A S A A M Q G G C P T S G C T K R C
1
P D S L A A G F T P T I I P A T A V T T V I V G A S A A M Q G G C P T S G C T K R C
42
92.9%
NZ_BMSZ01000006.1 and 4 others:
NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12790_lanthipeptide NZ_CP021707.1 Lanthipeptides: CCZ36_RS18195_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19730_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19730_lanthipeptide
Lanthipeptides: IE135_RS12790_lanthipeptide
1
P E S L A A G F T P T I I P A T A V T T V I V G A S A A M Q G G C P T S G C T K R C
42
P+S L A A G T P T I+P A T A V T T V I V G A S A A M Q G G C P T S G C T K R C
1
P D S L A A G I T P T I V P A T A V T T V I V G A S A A M Q G G C P T S G C T K R C
42
with 80 more sequence matches
Only the first 10 are displayed here.
83.3%
NZ_WHOM01000078.1 and 1 other:
NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29290_lanthipeptide
Lanthipeptides: GCN81_RS29290_lanthipeptide
1
P E S L A A G F T P T I I P A T A V T T V I V G A S A A M Q G G C P T S G C T K R C
42
P E S L A A G T P T I+P A T V I V G A S A A+Q G G C P T S G C T K R C
1
P E S L A A G I T P T I L P A T G V---I V G A S A A L Q G G C P T S G C T K R C
39
42.9%
NZ_CKMQ01000043.1 and 8 others:
NZ_CKMQ01000043.1 Lanthipeptides: AE832_RS09950_lanthipeptide NZ_CKMR01000002.1 Lanthipeptides: AD782_RS02065_lanthipeptide NZ_CKMR01000002.1 Lanthipeptides: AD782_RS02065_lanthipeptide NZ_FIXU01000003.1 Lanthipeptides: A1M11_RS01730_lanthipeptide NZ_FIXU01000003.1 Lanthipeptides: A1M11_RS01730_lanthipeptide NZ_LR216041.1 Lanthipeptides: E0F00_RS05470_lanthipeptide NZ_LR216046.1 Lanthipeptides: E0E82_RS05985_lanthipeptide NZ_LR216046.1 Lanthipeptides: E0E82_RS05985_lanthipeptide
Lanthipeptides: AE832_RS09950_lanthipeptide
9
T P T I I P A T A V T T V I V G A S A A M Q G G C P T S G C T K R C
42
T P T I I P A T + G C P T S G C T K C
2
T P T I I P A T I S F V G V T F T V T L N A G A C P T S G C T K S C
35
42.9%
NZ_CP015591.1 and 15 others:
NZ_CP078085.1 Lanthipeptides: KU891_RS29355_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29350_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29345_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29340_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29335_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptide
Lanthipeptides: A7A70_RS27550_lanthipeptide
1
P E S L A A G F T P T I I P A T A V T T V I V G A S A A M Q G G C P T S G C T K R C
42
P E+ A T P T I+ A T T V + C P T+ C T R C
5
P E T T P A--T P T I V E A T I A A T V S I---------C P T T K C T S R C
35
40.5%
NZ_CM000756.1 and 17 others:
NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptide NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14765_lanthipeptide NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptide
Lanthipeptides: BTHUR0011_RS14765_lanthipeptide
2
E S L A A G F T P T I I P A T A V T T V I V G A S A A M Q G G C P T S G C T K R C
42
E S A G T P I+ A + T + Q C P T S C+K C
1
E S S G A G-T P A I V T A I S A V T A V T A-----Q S P C P T S A C S K S C
35
40.5%
NZ_CP017953.1 and 15 others:
NZ_CP017953.1 Lanthipeptides: BAMY_RS16390_lanthipeptide NZ_CP021011.1 Lanthipeptides: B6257_RS06470_lanthipeptide NZ_CP021011.1 Lanthipeptides: B6257_RS06470_lanthipeptide NZ_CP041784.1 Lanthipeptides: FOV14_RS15890_lanthipeptide NZ_CP041784.1 Lanthipeptides: FOV14_RS15890_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS05695_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS05695_lanthipeptide NZ_CP097326.1 Lanthipeptides: M5J22_RS16180_lanthipeptide NZ_CP097326.1 Lanthipeptides: M5J22_RS16180_lanthipeptide NZ_CP097784.1 Lanthipeptides: MF619_RS16150_lanthipeptide NZ_CP097784.1 Lanthipeptides: MF619_RS16150_lanthipeptide NZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11805_lanthipeptide NZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11805_lanthipeptide NZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06815_lanthipeptide NZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06815_lanthipeptide
Lanthipeptides: BAMY_RS16390_lanthipeptide
9
T P T I I P A T A V----T T V I V G A S A A M Q G G C P T S G C T K R C
42
T P T++ + T T V S A A C P T S C T K+C
2
T P T V V L T A T I G L T G T T F T V T L S A A---S C P T S A C T K Q C
36
40.5%
NZ_PNGD01000001.1 and 1 other:
NZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00165_lanthipeptide
Lanthipeptides: CJ239_RS00165_lanthipeptide
9
T P T I I P A T A V T T V I V G A S A A M Q G G C P T S G C T K R C
42
T P T I I A T + G C P T S G C T K C
2
T P T I I A A T I S F A G V T F T V T L N A G A C P T S G C T K S C
35
38.1%
NZ_BLIS01000009.1 and 1 other:
NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04825_lanthipeptide
Lanthipeptides: GVO03_RS04825_lanthipeptide
1
P E S L A A G F T P T I I P A T A V T T V I V G A S A A M Q G G C P T S G C T K R C
42
P S A +T P I T V A+ C P T S C T+ C
3
P A S P A T P Y T P A I G K G V I A V T A F V S A N T-----C P T S A C T R A C
39
37.5%
NZ_LT575476.1 and 1 other:
NZ_LT575476.1 Lanthipeptides: BN6628_RS02295_lanthipeptide
Lanthipeptides: BN6628_RS02295_lanthipeptide
2
E S L A A G F T P T I I P A T A V T T V I V G A S A A M Q G G C P T S G C T K R C
42
E + G+T P A T V +V I A C P T S C T K C
13
E D V K G G W T P V---A T V V I S V I G L T M N A T P--C P T S A C T K S C
48
35.7%
NZ_CACZYW010000004.1 and 3 others:
NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptide NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide
Lanthipeptides: HUF10_RS02820_lanthipeptide
14
P A T A V T T V I V G A S A A M Q G G-C P T S G C T K R C
42
P A T T V I V S A + C P T+ C T+ C
3
P A T P A T P V I V A V S A Y V S D K T C P T T A C T R A C
32
35.7%
NZ_CP061868.1 and 1 other:
NZ_CP061868.1 Lanthipeptides: IE339_RS06335_lanthipeptide
Lanthipeptides: IE339_RS06335_lanthipeptide
8
F T P T I I P A T A V T T V I V G A S A A M Q G G C P T S G C T K R C
42
T P T I+ T A V T I C P T+ C T+ C
1
I T P T I V-I T A V T G Y I------S T N T C P T T S C T R A C
28

#### MIBiG 4.0 matches for MQC87_RS11030

31.0%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
21
V I V G A S A A M Q G G C P T S G C T K R C
42
V V G S A A C P T+ C T R C
19
V A V G V S A A F---C P T T K C T S R C
37
16.7%
BGC0002130.3 (QKI29070.1):
Lanthipeptide: cacaoidin
14
P A T A V T T V I V G A S A A M Q G G C
33
P T +V S A G C
4
P C T I Y A S V S A S I S A T A S W G C
23
14.3%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
33
C P T S G C T K R C
42
C P T+ C T +C
17
C P T T K C T S K C
26
allorf_114966_115073
Leader:
MPERSGNVRFG
Core:
P C R N V P A V S V P S A R T P P P W N W S C V
Core with dehydrations:
P Cys R N V P A V Dha V P Dha A R Dhb P P P W N W Dha Cys V

#### antiSMASH-DB 4.0 matches for allorf_114966_115073

100.0%
NZ_JALDPQ010000054.1 and 1 other:
NZ_JALDPQ010000054.1 Lanthipeptides: allorf_114966_115073_lanthipeptide
Lanthipeptides: allorf_114966_115073_lanthipeptide
1
P C R N V P A V S V P S A R T P P P W N W S C V
24
P C R N V P A V S V P S A R T P P P W N W S C V
1
P C R N V P A V S V P S A R T P P P W N W S C V
24
29.2%
NZ_BMSZ01000006.1 and 2 others:
NZ_BMSZ01000006.1 Lanthipeptides: allorf_235964_236128_lanthipeptide NZ_CP021707.1 Lanthipeptides: allorf_3962821_3962985_lanthipeptide
Lanthipeptides: allorf_235964_236128_lanthipeptide
15
T P P P W N W S C V
24
+P P W N S C V
13
S P R P W N R S C V
22
25.9%
NZ_CP058552.1:
Lanthipeptides: HW560_RS06640_lanthipeptide
8
V S V P S A R T P P P W N W S C
23
V S +A P W W C
12
V S T I T A D C T P G W T W V C
27
with 3 more sequence matches
25.0%
NZ_GL877172.1:
Lanthipeptides: allorf_5847948_5848169_lanthipeptide
1
P C R N V P A V S V P S A R T P P P W N W
21
P V P A + P+A P P P +
15
P G A R V P A G T A P A A L N P P P G P Y
35
18.2%
NZ_BMRY01000003.1 and 5 others:
NZ_BMRY01000003.1 Lanthipeptides: allorf_458543_458737_lanthipeptide NZ_CP084357.1 Lanthipeptides: allorf_8050125_8050319_lanthipeptide NZ_CP084357.1 Lanthipeptides: allorf_8050125_8050319_lanthipeptide NZ_KZ819178.1 Lanthipeptides: allorf_4075416_4075610_lanthipeptide NZ_KZ819178.1 Lanthipeptides: allorf_4075416_4075610_lanthipeptide
Lanthipeptides: allorf_458543_458737_lanthipeptide
15
T P P P W N W S C V
24
+P P W N W S C V
35
S P R P W N W S C V
44
16.2%
NZ_CP085876.1:
Lanthipeptides: allorf_0058816_0059013_lanthipeptide
1
P C R N V P A V S V P S A R T P P P W
19
P +P++ +P S + P P+
18
P Y F Q L P S I C L P S V Q A P H P F
36
allorf_114997_115104
Leader:
MRAEGTDTAGT
Core:
F R H G P N L T L P E R S G N P P H R A C P N V
Core with dehydrations:
F R H G P N L Dhb L P E R Dha G N P P H R A Cys P N V

#### antiSMASH-DB 4.0 matches for allorf_114997_115104

100.0%
NZ_JALDPQ010000054.1 and 1 other:
NZ_JALDPQ010000054.1 Lanthipeptides: allorf_114997_115104_lanthipeptide
Lanthipeptides: allorf_114997_115104_lanthipeptide
1
F R H G P N L T L P E R S G N P P H R A C P N V
24
F R H G P N L T L P E R S G N P P H R A C P N V
1
F R H G P N L T L P E R S G N P P H R A C P N V
24
29.2%
NZ_CP080269.1:
Lassopeptides: KXU80_RS08620_lassopeptide
4
G P N L T L P E R S G N P P H R A C P
22
G P N +P+++G H P
1
G P N G V I P D K N G K G G H N N H P
19
25.0%
NZ_CM000743.1:
Lanthipeptides: allorf_5304622_5304729_lanthipeptide
1
F R H G P N L T L P E R S G N P P H R A C
21
H P N+ ++ P H +C
3
L A H E P N I L E Y R K T K I S P H H S C
23
with 2 more sequence matches
15.0%
NZ_BBZG01000001.1 and 1 other:
NZ_FOBF01000002.1 Lanthipeptides: allorf_603810_604049_lanthipeptide
Lanthipeptides: allorf_1402466_1402705_lanthipeptide
2
R H G P N L T L P E R S G N P P H R A C P
22
R P P R S P P H + P
4
R G T P R C A F P A R S P R P P H A S V P
24
11.5%
NZ_CP047146.1:
Lanthipeptides: allorf_3674152_3674370_lanthipeptide
12
R S G N P P H R A C P N V
24
R S G+ P R C +
8
R S G S I P W R I C R E I
20

#### Lanthipeptide(s) for MQC87_RS11035

MQC87_RS11020
Leader:
MANPNVGILEEIDDQNLDAVSAA
Core:
G Q G W G T I V S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C K
Core with dehydrations:
G Q G W G Dhb I V Dha Dha L Dha Cys Y G A Dha Y V L G N N G N F Cys Dhb A Dhb A E Cys Q N N Cys K

#### antiSMASH-DB 4.0 matches for MQC87_RS11020

100.0%
NZ_BMRY01000003.1 and 24 others:
NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12370_lanthipeptide NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptide NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12780_lanthipeptide NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptide NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05285_lanthipeptide NZ_CP021707.1 Lanthipeptides: CCZ36_RS18205_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19425_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS34965_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11020_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32880_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: CD02_RS38630_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100145_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS18455_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19720_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS03735_lanthipeptide
Lanthipeptides: IE140_RS12370_lanthipeptide
1
G Q G W G T I V S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C K
38
G Q G W G T I V S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C K
1
G Q G W G T I V S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C K
38
94.7%
NZ_CP116355.1 and 1 other:
NZ_CP116355.1 Lanthipeptides: KPP03845_RS17815_lanthipeptide
Lanthipeptides: KPP03845_RS17815_lanthipeptide
1
G Q G W G T I V S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C K
38
G Q G W G T++S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C K
1
G Q G W G T V M S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C K
38
89.5%
NZ_WHOM01000078.1 and 1 other:
NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29300_lanthipeptide
Lanthipeptides: GCN81_RS29300_lanthipeptide
1
G Q G W G T I V S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C K
38
G Q G W G T +S S L S C Y G A S Y V L G N N G N F C T A T A E C Q+N C+
1
G Q G W G T T L S S L S C Y G A S Y V L G N N G N F C T A T A E C Q S N C Q
38
with 112 more sequence matches
Only the first 10 are displayed here.
71.1%
NZ_QKTG01000020.1 and 1 other:
NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS16920_lanthipeptide
Lanthipeptides: DEI99_RS16920_lanthipeptide
2
Q G W G T I V S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C K
38
Q G G T V++L S C Y G S+ L G N+G N F C T A T E C Q+N C K
1
Q G I G T T V T T L S C Y G V S W A L G N D G N F C T A T V E C Q S N C K
37
66.7%
NZ_JALGRP010000007.1 and 1 other:
NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12955_lanthipeptide
Lanthipeptides: MT347_RS12955_lanthipeptide
1
G Q G W G T I V S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C
37
G Q G W T ++S L+C Y G S+V G N N G C T A T E C Q N N C
2
G Q G W T T T I T S L T C Y G V S W V A G N N G Q V C T A T V E C Q N N C
38
55.3%
NZ_LT575476.1 and 1 other:
NZ_LT575476.1 Lanthipeptides: BN6628_RS02285_lanthipeptide
Lanthipeptides: BN6628_RS02285_lanthipeptide
4
W G T I V S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C K
38
W G T++++L+C G A S Y L G+ G C T A T E C N N C+
3
W G T V L T T L A C L G A S Y A L G D K G Q V C T A T V E C I N N C R
37
52.6%
NZ_BCEY01000006.1 and 1 other:
NZ_BCEY01000006.1 Lanthipeptides: GOZ53_RS01290_lanthipeptide
Lanthipeptides: GOZ53_RS01290_lanthipeptide
3
G W-G T I V S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C K
38
G W G S +S C S+ L G N+G C T T A E C Q C K
1
G W T G V A K S I V S C S L I S F A L G N D G W I C T W T A E C Q A T C K
37
50.0%
NZ_JALIRS010000003.1 and 3 others:
NZ_JALIRS010000003.1 Lanthipeptides: MOK21_RS07255_lanthipeptide NZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide NZ_JALNLQ010000002.1 Lanthipeptides: MWJ95_RS06810_lanthipeptide
Lanthipeptides: MOK21_RS07255_lanthipeptide
2
Q G W G-T I V S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C
37
+ W T I++S L+C A S Y+L G N G+ C T T E C Q C
3
E R W A E T I L T S L A C A A A S Y I L G N P G H V C T L T V E C Q K K C
39
50.0%
NZ_JAQFWW010000002.1 and 1 other:
NZ_JAQFWW010000002.1 Lanthipeptides: PDT38_RS11330_lanthipeptide
Lanthipeptides: PDT38_RS11330_lanthipeptide
4
W G T I V S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C K
38
W G T++++L S C A S ++G+ G C T T E C Q N N C+
3
W G T L L T T L S C L A A S I M I G D K G Q V C T G T V E C Q N N C R
37
47.4%
NC_015215.1 and 5 others:
NC_015215.1 Lanthipeptides: SGGBAA2069_RS00705_lanthipeptide NZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09795_lanthipeptide NZ_JAKUYO010000004.1 Lanthipeptides: MK556_RS09795_lanthipeptide NZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05350_lanthipeptide NZ_JAMDHZ010000003.1 Lanthipeptides: M5Q10_RS05350_lanthipeptide
Lanthipeptides: SGGBAA2069_RS00705_lanthipeptide
3
G W G T I V S S L-S C Y G A S Y V L G N N G N F C T A T A E C Q N N C K
38
G W + S+ S C S L G N+G C T T A E C Q C+
1
G W T G V A K S I T S C S L L S I G L G N D G W V C T W T A E C Q A T C R
37
47.4%
NC_017299.1 and 1 other:
NC_017299.1 Lanthipeptides: H04402_RS03105_lanthipeptide
Lanthipeptides: H04402_RS03105_lanthipeptide
5
G T I V S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C
37
G T I +L S Y +G N+G C T T E C Q N N C
5
G T I S I T L S V Y-----M G N D G K V C T W T V E C Q N N C
32
47.4%
NZ_WITJ01000001.1 and 1 other:
NZ_WITJ01000001.1 Lanthipeptides: GHI93_RS00065_lanthipeptide
Lanthipeptides: GHI93_RS00065_lanthipeptide
1
G Q G W G T I V S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C K
38
G W + S S+ + L G N N G C T T E C Q N C K
1
G W T W N L V F S S V----V T L A L G N N G Y V C T W T H E C Q A N C K
34
44.7%
NZ_BMVL01000013.1 and 1 other:
NZ_BMVL01000013.1 Lanthipeptides: IE257_RS28650_lanthipeptide
Lanthipeptides: IE257_RS28650_lanthipeptide
6
T I V S S L S C Y G A S Y V L G N N G N F C T A T A E C Q N N C K
38
T I +++ A S+ L G N N G+ C T T E C Q N C+
1
T I F E T V T Y T V A S W A L G N N G H L C T V T V E C Q K N C Q
33

#### MIBiG 4.0 matches for MQC87_RS11020

36.8%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
14
Y G A S Y V L G N N G N F C T A T A E C Q N N C
37
+ S L G N N G +C T T E C Q N C
6
F S L S N A L G N N G G W C T L T K E C Q P N C
29
31.6%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
14
Y G A S Y V L G N N G N F C T A T A E C Q N N C
37
Y S L G N G +C T T E C +C
4
Y N I S C R L G N K G A Y C T L T V E C M P S C
27
17.9%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
27
C T A T A E C Q N N C
37
C T + E C Q N C
28
C T L S K E C Q P N C
38
MQC87_RS11030
Leader:
MGDIAMNDATGYVSADELVELADA
Core:
P E S L A A G F T P T I I P A T A V T T V I V G A S A A M Q G G C P T S G C T K R C
Core with dehydrations:
P E Dha L A A G F Dhb P Dhb I I P A Dhb A V Dhb Dhb V I V G A Dha A A M Q G G Cys P Dhb Dha G Cys Dhb K R Cys

#### antiSMASH-DB 4.0 matches for MQC87_RS11030

100.0%
NZ_BNBJ01000003.1 and 9 others:
NZ_BNBJ01000003.1 Lanthipeptides: IE304_RS05295_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19415_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS19415_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11030_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: MQC87_RS11030_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32890_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: M1212_RS32890_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100135_lanthipeptide NZ_JNZV01000231.1 Lanthipeptides: BG84_RS0100135_lanthipeptide
Lanthipeptides: IE304_RS05295_lanthipeptide
1
P E S L A A G F T P T I I P A T A V T T V I V G A S A A M Q G G C P T S G C T K R C
42
P E S L A A G F T P T I I P A T A V T T V I V G A S A A M Q G G C P T S G C T K R C
1
P E S L A A G F T P T I I P A T A V T T V I V G A S A A M Q G G C P T S G C T K R C
42
97.6%
NZ_BMRY01000003.1 and 9 others:
NZ_BMRY01000003.1 Lanthipeptides: IE140_RS12360_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS34975_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS34975_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: CD02_RS0123035_lanthipeptide NZ_JNLT01000014.1 Lanthipeptides: CD02_RS0123035_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS18445_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS18445_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS03745_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS03745_lanthipeptide
Lanthipeptides: IE140_RS12360_lanthipeptide
1
P E S L A A G F T P T I I P A T A V T T V I V G A S A A M Q G G C P T S G C T K R C
42
P+S L A A G F T P T I I P A T A V T T V I V G A S A A M Q G G C P T S G C T K R C
1
P D S L A A G F T P T I I P A T A V T T V I V G A S A A M Q G G C P T S G C T K R C
42
92.9%
NZ_BMSZ01000006.1 and 4 others:
NZ_BMSZ01000006.1 Lanthipeptides: IE135_RS12790_lanthipeptide NZ_CP021707.1 Lanthipeptides: CCZ36_RS18195_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19730_lanthipeptide NZ_LZRD01000017.1 Lanthipeptides: A3Q37_RS19730_lanthipeptide
Lanthipeptides: IE135_RS12790_lanthipeptide
1
P E S L A A G F T P T I I P A T A V T T V I V G A S A A M Q G G C P T S G C T K R C
42
P+S L A A G T P T I+P A T A V T T V I V G A S A A M Q G G C P T S G C T K R C
1
P D S L A A G I T P T I V P A T A V T T V I V G A S A A M Q G G C P T S G C T K R C
42
with 80 more sequence matches
Only the first 10 are displayed here.
83.3%
NZ_WHOM01000078.1 and 1 other:
NZ_WHOM01000078.1 Lanthipeptides: GCN81_RS29290_lanthipeptide
Lanthipeptides: GCN81_RS29290_lanthipeptide
1
P E S L A A G F T P T I I P A T A V T T V I V G A S A A M Q G G C P T S G C T K R C
42
P E S L A A G T P T I+P A T V I V G A S A A+Q G G C P T S G C T K R C
1
P E S L A A G I T P T I L P A T G V---I V G A S A A L Q G G C P T S G C T K R C
39
42.9%
NZ_CKMQ01000043.1 and 8 others:
NZ_CKMQ01000043.1 Lanthipeptides: AE832_RS09950_lanthipeptide NZ_CKMR01000002.1 Lanthipeptides: AD782_RS02065_lanthipeptide NZ_CKMR01000002.1 Lanthipeptides: AD782_RS02065_lanthipeptide NZ_FIXU01000003.1 Lanthipeptides: A1M11_RS01730_lanthipeptide NZ_FIXU01000003.1 Lanthipeptides: A1M11_RS01730_lanthipeptide NZ_LR216041.1 Lanthipeptides: E0F00_RS05470_lanthipeptide NZ_LR216046.1 Lanthipeptides: E0E82_RS05985_lanthipeptide NZ_LR216046.1 Lanthipeptides: E0E82_RS05985_lanthipeptide
Lanthipeptides: AE832_RS09950_lanthipeptide
9
T P T I I P A T A V T T V I V G A S A A M Q G G C P T S G C T K R C
42
T P T I I P A T + G C P T S G C T K C
2
T P T I I P A T I S F V G V T F T V T L N A G A C P T S G C T K S C
35
42.9%
NZ_CP015591.1 and 15 others:
NZ_CP078085.1 Lanthipeptides: KU891_RS29355_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29350_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29345_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29340_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29335_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptide
Lanthipeptides: A7A70_RS27550_lanthipeptide
1
P E S L A A G F T P T I I P A T A V T T V I V G A S A A M Q G G C P T S G C T K R C
42
P E+ A T P T I+ A T T V + C P T+ C T R C
5
P E T T P A--T P T I V E A T I A A T V S I---------C P T T K C T S R C
35
40.5%
NZ_CM000756.1 and 17 others:
NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptide NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14765_lanthipeptide NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptide
Lanthipeptides: BTHUR0011_RS14765_lanthipeptide
2
E S L A A G F T P T I I P A T A V T T V I V G A S A A M Q G G C P T S G C T K R C
42
E S A G T P I+ A + T + Q C P T S C+K C
1
E S S G A G-T P A I V T A I S A V T A V T A-----Q S P C P T S A C S K S C
35
40.5%
NZ_CP017953.1 and 15 others:
NZ_CP017953.1 Lanthipeptides: BAMY_RS16390_lanthipeptide NZ_CP021011.1 Lanthipeptides: B6257_RS06470_lanthipeptide NZ_CP021011.1 Lanthipeptides: B6257_RS06470_lanthipeptide NZ_CP041784.1 Lanthipeptides: FOV14_RS15890_lanthipeptide NZ_CP041784.1 Lanthipeptides: FOV14_RS15890_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS05695_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS05695_lanthipeptide NZ_CP097326.1 Lanthipeptides: M5J22_RS16180_lanthipeptide NZ_CP097326.1 Lanthipeptides: M5J22_RS16180_lanthipeptide NZ_CP097784.1 Lanthipeptides: MF619_RS16150_lanthipeptide NZ_CP097784.1 Lanthipeptides: MF619_RS16150_lanthipeptide NZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11805_lanthipeptide NZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11805_lanthipeptide NZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06815_lanthipeptide NZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06815_lanthipeptide
Lanthipeptides: BAMY_RS16390_lanthipeptide
9
T P T I I P A T A V----T T V I V G A S A A M Q G G C P T S G C T K R C
42
T P T++ + T T V S A A C P T S C T K+C
2
T P T V V L T A T I G L T G T T F T V T L S A A---S C P T S A C T K Q C
36
40.5%
NZ_PNGD01000001.1 and 1 other:
NZ_PNGD01000001.1 Lanthipeptides: CJ239_RS00165_lanthipeptide
Lanthipeptides: CJ239_RS00165_lanthipeptide
9
T P T I I P A T A V T T V I V G A S A A M Q G G C P T S G C T K R C
42
T P T I I A T + G C P T S G C T K C
2
T P T I I A A T I S F A G V T F T V T L N A G A C P T S G C T K S C
35
38.1%
NZ_BLIS01000009.1 and 1 other:
NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04825_lanthipeptide
Lanthipeptides: GVO03_RS04825_lanthipeptide
1
P E S L A A G F T P T I I P A T A V T T V I V G A S A A M Q G G C P T S G C T K R C
42
P S A +T P I T V A+ C P T S C T+ C
3
P A S P A T P Y T P A I G K G V I A V T A F V S A N T-----C P T S A C T R A C
39
37.5%
NZ_LT575476.1 and 1 other:
NZ_LT575476.1 Lanthipeptides: BN6628_RS02295_lanthipeptide
Lanthipeptides: BN6628_RS02295_lanthipeptide
2
E S L A A G F T P T I I P A T A V T T V I V G A S A A M Q G G C P T S G C T K R C
42
E + G+T P A T V +V I A C P T S C T K C
13
E D V K G G W T P V---A T V V I S V I G L T M N A T P--C P T S A C T K S C
48
35.7%
NZ_CACZYW010000004.1 and 3 others:
NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptide NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide
Lanthipeptides: HUF10_RS02820_lanthipeptide
14
P A T A V T T V I V G A S A A M Q G G-C P T S G C T K R C
42
P A T T V I V S A + C P T+ C T+ C
3
P A T P A T P V I V A V S A Y V S D K T C P T T A C T R A C
32
35.7%
NZ_CP061868.1 and 1 other:
NZ_CP061868.1 Lanthipeptides: IE339_RS06335_lanthipeptide
Lanthipeptides: IE339_RS06335_lanthipeptide
8
F T P T I I P A T A V T T V I V G A S A A M Q G G C P T S G C T K R C
42
T P T I+ T A V T I C P T+ C T+ C
1
I T P T I V-I T A V T G Y I------S T N T C P T T S C T R A C
28

#### MIBiG 4.0 matches for MQC87_RS11030

31.0%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
21
V I V G A S A A M Q G G C P T S G C T K R C
42
V V G S A A C P T+ C T R C
19
V A V G V S A A F---C P T T K C T S R C
37
16.7%
BGC0002130.3 (QKI29070.1):
Lanthipeptide: cacaoidin
14
P A T A V T T V I V G A S A A M Q G G C
33
P T +V S A G C
4
P C T I Y A S V S A S I S A T A S W G C
23
14.3%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
33
C P T S G C T K R C
42
C P T+ C T +C
17
C P T T K C T S K C
26
allorf_114966_115073
Leader:
MPERSGNVRFG
Core:
P C R N V P A V S V P S A R T P P P W N W S C V
Core with dehydrations:
P Cys R N V P A V Dha V P Dha A R Dhb P P P W N W Dha Cys V

#### antiSMASH-DB 4.0 matches for allorf_114966_115073

100.0%
NZ_JALDPQ010000054.1 and 1 other:
NZ_JALDPQ010000054.1 Lanthipeptides: allorf_114966_115073_lanthipeptide
Lanthipeptides: allorf_114966_115073_lanthipeptide
1
P C R N V P A V S V P S A R T P P P W N W S C V
24
P C R N V P A V S V P S A R T P P P W N W S C V
1
P C R N V P A V S V P S A R T P P P W N W S C V
24
29.2%
NZ_BMSZ01000006.1 and 2 others:
NZ_BMSZ01000006.1 Lanthipeptides: allorf_235964_236128_lanthipeptide NZ_CP021707.1 Lanthipeptides: allorf_3962821_3962985_lanthipeptide
Lanthipeptides: allorf_235964_236128_lanthipeptide
15
T P P P W N W S C V
24
+P P W N S C V
13
S P R P W N R S C V
22
25.9%
NZ_CP058552.1:
Lanthipeptides: HW560_RS06640_lanthipeptide
8
V S V P S A R T P P P W N W S C
23
V S +A P W W C
12
V S T I T A D C T P G W T W V C
27
with 3 more sequence matches
25.0%
NZ_GL877172.1:
Lanthipeptides: allorf_5847948_5848169_lanthipeptide
1
P C R N V P A V S V P S A R T P P P W N W
21
P V P A + P+A P P P +
15
P G A R V P A G T A P A A L N P P P G P Y
35
18.2%
NZ_BMRY01000003.1 and 5 others:
NZ_BMRY01000003.1 Lanthipeptides: allorf_458543_458737_lanthipeptide NZ_CP084357.1 Lanthipeptides: allorf_8050125_8050319_lanthipeptide NZ_CP084357.1 Lanthipeptides: allorf_8050125_8050319_lanthipeptide NZ_KZ819178.1 Lanthipeptides: allorf_4075416_4075610_lanthipeptide NZ_KZ819178.1 Lanthipeptides: allorf_4075416_4075610_lanthipeptide
Lanthipeptides: allorf_458543_458737_lanthipeptide
15
T P P P W N W S C V
24
+P P W N W S C V
35
S P R P W N W S C V
44
16.2%
NZ_CP085876.1:
Lanthipeptides: allorf_0058816_0059013_lanthipeptide
1
P C R N V P A V S V P S A R T P P P W
19
P +P++ +P S + P P+
18
P Y F Q L P S I C L P S V Q A P H P F
36
allorf_114997_115104
Leader:
MRAEGTDTAGT
Core:
F R H G P N L T L P E R S G N P P H R A C P N V
Core with dehydrations:
F R H G P N L Dhb L P E R Dha G N P P H R A Cys P N V

#### antiSMASH-DB 4.0 matches for allorf_114997_115104

100.0%
NZ_JALDPQ010000054.1 and 1 other:
NZ_JALDPQ010000054.1 Lanthipeptides: allorf_114997_115104_lanthipeptide
Lanthipeptides: allorf_114997_115104_lanthipeptide
1
F R H G P N L T L P E R S G N P P H R A C P N V
24
F R H G P N L T L P E R S G N P P H R A C P N V
1
F R H G P N L T L P E R S G N P P H R A C P N V
24
29.2%
NZ_CP080269.1:
Lassopeptides: KXU80_RS08620_lassopeptide
4
G P N L T L P E R S G N P P H R A C P
22
G P N +P+++G H P
1
G P N G V I P D K N G K G G H N N H P
19
25.0%
NZ_CM000743.1:
Lanthipeptides: allorf_5304622_5304729_lanthipeptide
1
F R H G P N L T L P E R S G N P P H R A C
21
H P N+ ++ P H +C
3
L A H E P N I L E Y R K T K I S P H H S C
23
with 2 more sequence matches
15.0%
NZ_BBZG01000001.1 and 1 other:
NZ_FOBF01000002.1 Lanthipeptides: allorf_603810_604049_lanthipeptide
Lanthipeptides: allorf_1402466_1402705_lanthipeptide
2
R H G P N L T L P E R S G N P P H R A C P
22
R P P R S P P H + P
4
R G T P R C A F P A R S P R P P H A S V P
24
11.5%
NZ_CP047146.1:
Lanthipeptides: allorf_3674152_3674370_lanthipeptide
12
R S G N P P H R A C P N V
24
R S G+ P R C +
8
R S G S I P W R I C R E I
20
allorf_130072_130218
Leader:
MTPRHAARSQGS
Core:
F A T T V R R F G R C P S E G G A E E F I P P G M P P Y A I S P L E V R
Core with dehydrations:
F A Dhb Dhb V R R F G R Cys P Dha E G G A E E F I P P G M P P Y A I Dha P L E V R

#### antiSMASH-DB 4.0 matches for allorf_130072_130218

100.0%
NZ_BNBJ01000003.1 and 3 others:
NZ_CP079114.1 Lanthipeptides: allorf_4422232_4422378_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: allorf_130072_130218_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: allorf_031162_031308_lanthipeptide
Lanthipeptides: allorf_023668_023814_lanthipeptide
1
F A T T V R R F G R C P S E G G A E E F I P P G M P P Y A I S P L E V R
36
F A T T V R R F G R C P S E G G A E E F I P P G M P P Y A I S P L E V R
1
F A T T V R R F G R C P S E G G A E E F I P P G M P P Y A I S P L E V R
36
97.2%
NZ_BMSZ01000006.1:
Lanthipeptides: allorf_251197_251343_lanthipeptide
1
F A T T V R R F G R C P S E G G A E E F I P P G M P P Y A I S P L E V R
36
F A T T V R R F G R C P S E G G A E E I P P G M P P Y A I S P L E V R
1
F A T T V R R F G R C P S E G G A E E S I P P G M P P Y A I S P L E V R
36
94.4%
NZ_LZRD01000017.1:
Lanthipeptides: allorf_103132_103278_lanthipeptide
1
F A T T V R R F G R C P S E G G A E E F I P P G M P P Y A I S P L E V R
36
F A T T V R R G R C P S E G G A E E I P P G M P P Y A I S P L E V R
1
F A T T V R R S G R C P S E G G A E E S I P P G M P P Y A I S P L E V R
36
with 4 more sequence matches
24.3%
NZ_QLMA01000007.1:
Lanthipeptides: CLV59_RS20825_lanthipeptide
3
T T V R R F G R C P S E G G A E E F I P P G
24
T T V C P+ I P P G
9
T T V M S I R T C P T V V D T C S T I P P G
30
18.4%
NZ_FMXV01000009.1:
Lanthipeptides: allorf_148352_148558_lanthipeptide
8
F G R C P S E G G A E E F I P P
23
G C P S G +P P
20
I G H C P S A G H N A R R L P P
35
16.7%
NZ_ML974127.1:
Lanthipeptides: EPL00_RS07380_lanthipeptide
10
R C P S E G G A E E F I
21
+C P G G A F+
19
K C P D C G G A L T F V
30
13.9%
NZ_CP119804.1:
Lanthipeptides: allorf_1905850_1905972_lanthipeptide
5
V R R F G R C P S E G G A E E
19
+ R F R C S + +
3
I N R F A R C D S H H S S A D
17

#### MIBiG 4.0 matches for allorf_130072_130218

13.9%
BGC0001639.3 (OUH62395.1):
Lasso peptide: klebsidin
13
S E G G A E E F I P P
23
S+G E F P
2
S D G P I I E F F N P
12

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 18.33 out of 19.52
Confidence: strong
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 18.39 out of 25.31
Confidence: medium
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.54 out of 18.46
Confidence: medium
Additional weak hits (3):
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.49 out of 19.26
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.12 out of 27.78
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 19.16 out of 29.25
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

MQC87_RS11020 - Class II
  Cleavage pHMM score: -2.30
  RODEO score: 0
  Monoisotopic mass: 3790.7 Da
  Molecular weight: 3793.1 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3811.2 Da N = 1
    3829.2 Da N = 2
    3847.2 Da N = 3
MQC87_RS11030 - Class II
  Cleavage pHMM score: -3.80
  RODEO score: 0
  Monoisotopic mass: 3855.0 Da
  Molecular weight: 3857.5 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3875.5 Da N = 1
    3893.5 Da N = 2
    3911.5 Da N = 3
    3929.5 Da N = 4
    3947.6 Da N = 5
    3965.6 Da N = 6
    3983.6 Da N = 7
allorf_114966_115073 - Class II
  Cleavage pHMM score: -6.10
  RODEO score: 0
  Monoisotopic mass: 2547.3 Da
  Molecular weight: 2548.9 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2566.9 Da N = 1
    2585.0 Da N = 2
allorf_114997_115104 - Class II
  Cleavage pHMM score: -6.60
  RODEO score: 0
  Monoisotopic mass: 2629.3 Da
  Molecular weight: 2630.9 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2649.0 Da N = 1
allorf_130072_130218 - Class II
  Cleavage pHMM score: -5.40
  RODEO score: 0
  Monoisotopic mass: 3862.0 Da
  Molecular weight: 3864.4 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3882.4 Da N = 1
    3900.4 Da N = 2
    3918.5 Da N = 3
MQC87_RS11020 - Class II
  Cleavage pHMM score: -2.30
  RODEO score: 0
  Monoisotopic mass: 3790.7 Da
  Molecular weight: 3793.1 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3811.2 Da N = 1
    3829.2 Da N = 2
    3847.2 Da N = 3
MQC87_RS11030 - Class II
  Cleavage pHMM score: -3.80
  RODEO score: 0
  Monoisotopic mass: 3855.0 Da
  Molecular weight: 3857.5 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3875.5 Da N = 1
    3893.5 Da N = 2
    3911.5 Da N = 3
    3929.5 Da N = 4
    3947.6 Da N = 5
    3965.6 Da N = 6
    3983.6 Da N = 7
allorf_114966_115073 - Class II
  Cleavage pHMM score: -6.10
  RODEO score: 0
  Monoisotopic mass: 2547.3 Da
  Molecular weight: 2548.9 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2566.9 Da N = 1
    2585.0 Da N = 2
allorf_114997_115104 - Class II
  Cleavage pHMM score: -6.60
  RODEO score: 0
  Monoisotopic mass: 2629.3 Da
  Molecular weight: 2630.9 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2649.0 Da N = 1

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsQ1 | Two-component system AfsQ1-Q2, activator of antibiotic production
CatR | H2O2-responsive repressor
RpoN | Regulator of nitrogen assimilation and virulence

NZ_JALDPQ010000058.1 - Region 1 - butyrolactone,ectoine
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 32,952 - 48,382 nt. (total: 15,431 nt) Show pHMM detection rules used
Region on contig edge.
ectoine: ectoine_synt
butyrolactone: AfsA

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
MQC87_RS12510: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

MQC87_RS12550: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: PPTase
MQC87_RS12530: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

Ligases: ligase
MQC87_RS12495: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ectoine | butyrolactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001778.5 |  |  | 0.55 | other (other) | showdomycin | Streptomyces showdoensis
BGC0000849.4 |  |  | 0.48 | other (butyrolactone) | SCB1, SCB2, SCB3 | Streptomyces coelicolor A3(2)
BGC0000848.5 |  |  | 0.48 | other (other) | A-factor | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000850.5 |  |  | 0.33 | other (other) | γ-butyrolactone | Streptomyces acidiscabies
BGC0000706.3 |  |  | 0.29 | saccharide | kanamycin | Streptomyces kanamyceticus
BGC0002276.2 |  |  | 0.26 | NRPS | choline | Aspergillus nidulans FGSC A4
BGC0001641.4 |  |  | 0.25 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001723.5 |  |  | 0.25 | PKS | oviedomycin | Streptomyces antibioticus
BGC0000003.3 |  |  | 0.24 | PKS | AF-toxin | Alternaria alternata
BGC0002675.2 |  |  | 0.24 | PKS | prodigiosin | Pseudoalteromonas rubra

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000849.4 |  | 0.77 | other (butyrolactone) | SCB1, SCB2, SCB3 | Streptomyces coelicolor A3(2)
BGC0000848.5 |  | 0.77 | other (other) | A-factor | Streptomyces griseus subsp. griseus NBRC 13350
BGC0002276.2 |  | 0.61 | NRPS | choline | Aspergillus nidulans FGSC A4
BGC0001778.5 |  | 0.58 | other (other) | showdomycin | Streptomyces showdoensis
BGC0001641.4 |  | 0.58 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000850.5 |  | 0.58 | other (other) | γ-butyrolactone | Streptomyces acidiscabies
BGC0002578.2 |  | 0.48 | other (other) | gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F | Streptomyces venezuelae ATCC 10712
BGC0000231.5 |  | 0.47 | PKS | griseusin A, griseusin B | Streptomyces griseus
BGC0000234.5 |  | 0.45 | PKS | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0001723.5 |  | 0.45 | PKS | oviedomycin | Streptomyces antibioticus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.82 out of 18.46
Confidence: medium
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05
Confidence: medium
Additional weak hits (14):
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.38 out of 20.01
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 16.99 out of 30.97
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.74 out of 20.01
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.22 out of 20.01
Confidence: weak
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.04 out of 18.57
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 15.55 out of 28.14
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.77 out of 29.38
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.22 out of 20.01
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.36 out of 20.01
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.53 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.30 out of 26.06
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.92 out of 30.22
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.24 out of 32.93
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.92 out of 28.14
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsR | Pleiotropic regulatory for antibiotic production
RpoN | Regulator of nitrogen assimilation and virulence

NZ_JALDPQ010000059.1 - Region 1 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 35,765 - 76,817 nt. (total: 41,053 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase
MQC87_RS12775: alcohol dehydrogenase

smcogs
  SMCOG1040: alcohol dehydrogenase

MQC87_RS12880: oxidoreductase

smcogs
  SMCOG1161: oxidoreductase

Transferases: kinase methyltransferase
MQC87_RS12780: PfkB domain protein

smcogs
  SMCOG1276: PfkB domain protein

MQC87_RS12885: Methylation

MITE
  MITE0000155Methylation (identity: 90.20%)
smcogs
  SMCOG1150: isoprenylcysteine carboxyl methyltransferase

Ligases: ligase synthase
MQC87_RS12830: carboxylate-amine ligase

smcogs
  SMCOG1165: carboxylate-amine ligase

MQC87_RS12890: chalcone and stilbene synthase domain protein

smcogs
  SMCOG1024: chalcone and stilbene synthase domain protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000282.3 |  | 0.89 | PKS | 2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3 |  | 0.53 | PKS | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0001647.3 |  | 0.47 | PKS | lagunapyrone A, lagunapyrone B, lagunapyrone C | Streptomyces sp. MP131-18
BGC0001964.2 |  | 0.45 | PKS | alkylpyrone-407, alkylpyrone-393 | Cystobacterineae bacterium
BGC0002362.3 |  | 0.45 | PKS | loseolamycin A1, loseolamycin A2 | Micromonospora endolithica
BGC0001927.4 |  | 0.44 | other (other) | A-94964 | Streptomyces sp.
BGC0001366.5 |  | 0.41 | PKS | BE-24566B, zunyimycin A | Streptomyces sp. FJS31-2
BGC0001850.4 |  | 0.41 | other (shikimate-derived) | diazaquinomycin A, diazaquinomycin E, diazaquinomycin F, diazaquinomycin G | Streptomyces sp. F001
BGC0001965.4 |  | 0.41 | other (other) | nybomycin | Streptomyces albus subsp. chlorinus
BGC0002305.2 |  | 0.41 | other (other) | legonoxamine A, desferrioxamine B, legonoxamine B | Streptomyces sp.

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000282.3 |  | 0.89 | PKS | 2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3 |  | 0.53 | PKS | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0001647.3 |  | 0.47 | PKS | lagunapyrone A, lagunapyrone B, lagunapyrone C | Streptomyces sp. MP131-18
BGC0001964.2 |  | 0.45 | PKS | alkylpyrone-407, alkylpyrone-393 | Cystobacterineae bacterium
BGC0002362.3 |  | 0.45 | PKS | loseolamycin A1, loseolamycin A2 | Micromonospora endolithica
BGC0001927.4 |  | 0.44 | other (other) | A-94964 | Streptomyces sp.
BGC0001366.5 |  | 0.41 | PKS | BE-24566B, zunyimycin A | Streptomyces sp. FJS31-2
BGC0001850.4 |  | 0.41 | other (shikimate-derived) | diazaquinomycin A, diazaquinomycin E, diazaquinomycin F, diazaquinomycin G | Streptomyces sp. F001
BGC0001965.4 |  | 0.41 | other (other) | nybomycin | Streptomyces albus subsp. chlorinus
BGC0002305.2 |  | 0.41 | other (other) | legonoxamine A, desferrioxamine B, legonoxamine B | Streptomyces sp.

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26
Confidence: medium
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 27.19 out of 36.53
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.20 out of 23.79
Confidence: medium
Additional weak hits (3):
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 18.31 out of 36.54
Confidence: weak
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 13.81 out of 18.57
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.53 out of 21.55
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
DmdR1 | Iron(II)-dependent repressor
IolR | Regulator of the inositol catabolism

NZ_JALDPQ010000059.1 - Region 2 - melanin,terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 93,422 - 121,914 nt. (total: 28,493 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)
melanin: melC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase oxygenase
MQC87_RS13085: aldo/keto reductase family oxidoreductase

smcogs
  SMCOG1039: aldo/keto reductase family oxidoreductase

MQC87_RS13185: cytochrome P450

smcogs
  SMCOG1007: cytochrome P450

Transferases: glycosyltransferase
MQC87_RS13130: glycosyl transferase group 1

smcogs
  SMCOG1045: glycosyl transferase group 1

MQC87_RS13135: sugar transferase

smcogs
  SMCOG1146: sugar transferase

MQC87_RS13155: glycosyl transferase group 1

smcogs
  SMCOG1045: glycosyl transferase group 1

Hydrolases: hydrolase
MQC87_RS13125: isochorismatase

smcogs
  SMCOG1027: isochorismatase

Ligases: synthetase
MQC87_RS13120: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | melanin | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000911.3 |  |  | 0.63 | other (other) | melanin | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000910.3 |  |  | 0.50 | other (other) | melanin | Streptomyces coelicolor A3(2)
BGC0000909.3 |  |  | 0.30 | other (other) | melanin | Streptomyces avermitilis
BGC0000912.3 |  |  | 0.26 | other (other) | melanin | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000800.5 |  |  | 0.26 | saccharide | xanthan | Xanthomonas campestris
BGC0001529.5 |  |  | 0.22 | other (other) | benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K | Streptomyces sp. RI18
BGC0000786.3 |  |  | 0.21 | saccharide | O-antigen | Edwardsiella ictaluri 93-146
BGC0000868.5 |  |  | 0.20 | other (other) | teichuronic acid | Bacillus subtilis subsp. subtilis str. 168
BGC0000790.3 |  |  | 0.18 | saccharide | O-antigen | Escherichia coli
BGC0000651.5 |  |  | 0.17 | terpene | KS-505a | Streptomyces argenteolus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000911.3 |  | 0.86 | other (other) | melanin | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000910.3 |  | 0.79 | other (other) | melanin | Streptomyces coelicolor A3(2)
BGC0000909.3 |  | 0.64 | other (other) | melanin | Streptomyces avermitilis
BGC0000912.3 |  | 0.59 | other (other) | melanin | Streptomyces griseus subsp. griseus NBRC 13350
BGC0002397.2 |  | 0.53 | terpene | astallatene | Arabidopsis thaliana
BGC0000908.3 |  | 0.52 | other (other) | melanin | Streptomyces avermitilis
BGC0000868.5 |  | 0.52 | other (other) | teichuronic acid | Bacillus subtilis subsp. subtilis str. 168
BGC0002400.2 |  | 0.49 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0000677.5 |  | 0.48 | terpene | cyclooctatin | Streptomyces melanosporofaciens
BGC0000800.5 |  | 0.47 | saccharide | xanthan | Xanthomonas campestris

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP
diterpene precursor |  | GGPP | C20 | acyclic | PP
sesterterpene precursor |  | GFPP | C25 | acyclic | PP
triterpene precursor |  | HPP | C30 | acyclic | PP

Genes with terpene domains:
MQC87_RS13120: PT_FPPS_like
Domain 1 (58 - 339): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: unknown

Reactions:
  IPP, DMAPP → FPP
  IPP, DMAPP → GGPP
  IPP, DMAPP → GFPP
  IPP, DMAPP → HPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.52 out of 23.79
Confidence: medium
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.92 out of 20.47
Confidence: medium
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.37 out of 20.47
Confidence: medium
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.00 out of 26.85
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.52 out of 23.79
Confidence: medium
Additional weak hits (4):
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.00 out of 28.14
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 18.35 out of 30.97
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.45 out of 30.25
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.19 out of 28.19
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
GFPP | Geranylfarnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
HPP | Hexaprenyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
IolR | Regulator of the inositol catabolism
RutR | Regulator of the pyrimidine and purine metabolism
VqsM | Regulator of quorum-sensing signalling systems

NZ_JALDPQ010000059.1 - Region 3 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 122,838 - 134,205 nt. (total: 11,368 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002115.3 |  | 0.74 | ribosomal | streptamidine | Streptomyces albidoflavus J1074
BGC0002306.2 |  | 0.43 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000551.5 |  | 0.42 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000513.3 |  | 0.42 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0001639.3 |  | 0.41 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0001579.4 |  | 0.40 | ribosomal | duramycin | Streptomyces cinnamoneus
BGC0000616.4 |  | 0.39 | ribosomal | amylocyclicin | Bacillus velezensis FZB42
BGC0000571.3 |  | 0.37 | ribosomal | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001863.4 |  | 0.35 | ribosomal, terpene | bacillicn CER074 | Bacillus mycoides
BGC0002289.2 |  | 0.35 | ribosomal | Leepeptin | Streptomyces leeuwenhoekii

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002115.3 |  | 0.74 | ribosomal | streptamidine | Streptomyces albidoflavus J1074
BGC0002306.2 |  | 0.43 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000551.5 |  | 0.42 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000513.3 |  | 0.42 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0001639.3 |  | 0.41 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0001579.4 |  | 0.40 | ribosomal | duramycin | Streptomyces cinnamoneus
BGC0000616.4 |  | 0.39 | ribosomal | amylocyclicin | Bacillus velezensis FZB42
BGC0000571.3 |  | 0.37 | ribosomal | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001863.4 |  | 0.35 | ribosomal, terpene | bacillicn CER074 | Bacillus mycoides
BGC0002289.2 |  | 0.35 | ribosomal | Leepeptin | Streptomyces leeuwenhoekii

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.04 out of 23.79
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16
Confidence: strong
Additional weak hits (2):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.88 out of 29.38
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 12.45 out of 28.14
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
IolR | Regulator of the inositol catabolism

NZ_JALDPQ010000059.1 - Region 4 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 220,868 - 263,725 nt. (total: 42,858 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
MQC87_RS13790: aldo/keto reductase family oxidoreductase

smcogs
  SMCOG1039: aldo/keto reductase family oxidoreductase

MQC87_RS13810: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Transferases: acyltransferase
MQC87_RS13860: acyltransferase

smcogs
  SMCOG1141: acyltransferase

Ligases: ligase
MQC87_RS13765: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001135.5 |  | 0.64 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0002135.2 |  | 0.63 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0000307.4 |  | 0.63 | NRPS | AbT1 | Aureobasidium pullulans
BGC0001166.5 |  | 0.63 | NRPS | HC-toxin | Alternaria jesenskae
BGC0001240.4 |  | 0.62 | NRPS | serinocyclin A, serinocyclin B | Metarhizium robertsii
BGC0001758.4 |  | 0.62 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001641.4 |  | 0.62 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000342.4 |  | 0.62 | NRPS | enniatin | Fusarium equiseti
BGC0001132.4 |  | 0.62 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  | 0.62 | NRPS | icosalide A, icosalide B | Burkholderia gladioli

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001135.5 |  | 0.64 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0002135.2 |  | 0.63 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0000307.4 |  | 0.63 | NRPS | AbT1 | Aureobasidium pullulans
BGC0001166.5 |  | 0.63 | NRPS | HC-toxin | Alternaria jesenskae
BGC0001240.4 |  | 0.62 | NRPS | serinocyclin A, serinocyclin B | Metarhizium robertsii
BGC0001758.4 |  | 0.62 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001641.4 |  | 0.62 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000342.4 |  | 0.62 | NRPS | enniatin | Fusarium equiseti
BGC0001132.4 |  | 0.62 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  | 0.62 | NRPS | icosalide A, icosalide B | Burkholderia gladioli

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
No hits above weak threshold.
Weak hits (4):
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 20.57 out of 32.74
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.56 out of 21.55
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.74 out of 29.65
Confidence: weak
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 21.74 out of 29.72
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 6, location 220867 - 263725:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
MQC87_RS13765: X
AMP-binding (12..413): X
nrpys: (unknown)

SVM prediction details:
  Predicted physicochemical class:
    N/A
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LTATFDVAFLEMALMTGADVACYGLTEATVNSTL
  Nearest Stachelhaus code(s):
    Ac-OH-Orn DVWALGAVNK (85% 8Å match)
  Stachelhaus code match:
    70% (weak)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---

NZ_JALDPQ010000059.1 - Region 5 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 339,742 - 350,539 nt. (total: 10,798 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
MQC87_RS14235: 3-hydroxyisobutyrate dehydrogenase

smcogs
  SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

Lyases: decarboxylase
MQC87_RS14255: diaminopimelate decarboxylase

smcogs
  SMCOG1264: diaminopimelate decarboxylase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001778.5 |  | 0.37 | other (other) | showdomycin | Streptomyces showdoensis
BGC0001575.4 |  | 0.34 | NRPS | PZN5, PZN6, PZN7, PZN9, PZN10, PZN11 | Ruminococcus sp. 5_1_39BFAA
BGC0001891.3 |  | 0.32 | other (other) | closthioamide | Ruminiclostridium cellulolyticum H10
BGC0001285.5 |  | 0.32 | other (fatty acid) | pseudopyronine A, pseudopyronine B | Pseudomonas putida
BGC0001882.3 |  | 0.31 | PKS | chrysoxanthone A, chrysoxanthone B, chrysoxanthone C | Penicillium rubens Wisconsin 54-1255
BGC0000729.3 |  | 0.31 | saccharide | capsular polysaccharide | Klebsiella pneumoniae
BGC0000728.5 |  | 0.31 | saccharide | capsular polysaccharide | Klebsiella pneumoniae subsp. ozaenae
BGC0000975.5 |  | 0.30 | NRPS, PKS | Cryptophycin A | Nostoc sp. ATCC 53789
BGC0000791.3 |  | 0.30 | saccharide | O-antigen | Cronobacter sakazakii
BGC0000730.3 |  | 0.28 | saccharide | capsular polysaccharide | Klebsiella pneumoniae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001778.5 |  | 0.37 | other (other) | showdomycin | Streptomyces showdoensis
BGC0001575.4 |  | 0.34 | NRPS | PZN5, PZN6, PZN7, PZN9, PZN10, PZN11 | Ruminococcus sp. 5_1_39BFAA
BGC0001891.3 |  | 0.32 | other (other) | closthioamide | Ruminiclostridium cellulolyticum H10
BGC0001285.5 |  | 0.32 | other (fatty acid) | pseudopyronine A, pseudopyronine B | Pseudomonas putida
BGC0001882.3 |  | 0.31 | PKS | chrysoxanthone A, chrysoxanthone B, chrysoxanthone C | Penicillium rubens Wisconsin 54-1255
BGC0000729.3 |  | 0.31 | saccharide | capsular polysaccharide | Klebsiella pneumoniae
BGC0000728.5 |  | 0.31 | saccharide | capsular polysaccharide | Klebsiella pneumoniae subsp. ozaenae
BGC0000975.5 |  | 0.30 | NRPS, PKS | Cryptophycin A | Nostoc sp. ATCC 53789
BGC0000791.3 |  | 0.30 | saccharide | O-antigen | Cronobacter sakazakii
BGC0000730.3 |  | 0.28 | saccharide | capsular polysaccharide | Klebsiella pneumoniae

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.26 out of 19.26
Confidence: medium
Additional weak hits (2):
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.69 out of 20.97
Confidence: weak
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.04 out of 27.55
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein

NZ_JALDPQ010000061.1 - Region 1 - NRPS,NRPS-like,T1PKS,hglE-KS,terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 192,578 - 287,687 nt. (total: 95,110 nt) Show pHMM detection rules used
hglE-KS: (hglE or hglD)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxygenase
MQC87_RS16655: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

MQC87_RS16660: alcohol dehydrogenase

smcogs
  SMCOG1040: alcohol dehydrogenase

MQC87_RS16795: dehydrogenase

smcogs
  SMCOG1072: dehydrogenase

MQC87_RS16830: cytochrome P450

smcogs
  SMCOG1007: cytochrome P450

MQC87_RS16840: cytochrome P450

smcogs
  SMCOG1007: cytochrome P450

MQC87_RS16915: dehydrogenase

smcogs
  SMCOG1222: dehydrogenase

Transferases: acylase aminotransferase glycosyltransferase kinase methyltransferase
MQC87_RS16635: glycerol kinase

smcogs
  SMCOG1210: glycerol kinase

MQC87_RS16720: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

MQC87_RS16775: aminotransferase

smcogs
  SMCOG1019: aminotransferase

MQC87_RS16820: aminotransferase class V

smcogs
  SMCOG1139: aminotransferase class V

MQC87_RS16880: methyltransferase

smcogs
  SMCOG1089: methyltransferase

MQC87_RS16895: glycosyltransferase, MGT family

smcogs
  SMCOG1062: glycosyltransferase, MGT family

MQC87_RS16900: glycosyl transferase group 1

smcogs
  SMCOG1045: glycosyl transferase group 1

Hydrolases: esterase
MQC87_RS16835: thioesterase

smcogs
  SMCOG1004: thioesterase

MQC87_RS16845: thioesterase

smcogs
  SMCOG1004: thioesterase

Lyases: dehydratase
MQC87_RS16715: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

MQC87_RS16750: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: ligase synthase synthetase
MQC87_RS16725: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

MQC87_RS16730: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

MQC87_RS16810: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

MQC87_RS16825: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

MQC87_RS16910: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | hglE-KS | T1PKS | NRPS | NRPS-like | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | --- | --- | ---
BGC0001268.4 |  |  |  |  |  | 1.01 | NRPS, PKS | fusarin C | Fusarium fujikuroi
BGC0001249.5 |  |  |  |  |  | 0.81 | NRPS | dimethylcoprogen | Alternaria alternata
BGC0001132.4 |  |  |  |  |  | 0.72 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002286.3 |  |  |  |  |  | 0.70 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  |  |  |  |  | 0.70 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  |  |  |  |  | 0.68 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0002164.2 |  |  |  |  |  | 0.67 | NRPS | peramine | Epichloe festucae
BGC0002171.2 |  |  |  |  |  | 0.67 | NRPS, PKS | pyrophen, campyrone B | Aspergillus niger ATCC 1015
BGC0002275.2 |  |  |  |  |  | 0.67 | NRPS, PKS | pyrophen, campyrone B | Aspergillus niger CBS 101883
BGC0001641.4 |  |  |  |  |  | 0.67 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000664.5 |  | 0.74 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001249.5 |  | 0.72 | NRPS | dimethylcoprogen | Alternaria alternata
BGC0000649.3 |  | 0.70 | terpene | carotenoid | Streptomyces griseus subsp. griseus NBRC 13350
BGC0002164.2 |  | 0.69 | NRPS | peramine | Epichloe festucae
BGC0001132.4 |  | 0.69 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002286.3 |  | 0.68 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  | 0.68 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  | 0.67 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001456.3 |  | 0.67 | terpene | isorenieratene | Streptomyces argillaceus
BGC0001641.4 |  | 0.66 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
tetraterpene | C40 carotenoid |  | C40 | unknown | unknown

Genes with terpene domains:
MQC87_RS16910: PT_FPPS_like
Domain 1 (26 - 326): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: unknown

Reactions:
  IPP, DMAPP → FPP
  IPP, DMAPP → GGPP
  IPP, DMAPP → GFPP
  IPP, DMAPP → HPP

MQC87_RS16920: PT_phytoene_like
Domain 1 (16 - 313): Prenyltransferase; Phytoene synthase like
Subtype: unknown

Reactions:
  FPP → PSPP
  FPP → squalene
  FPP → diapophytoene
  GGPP → phytoene
  PSPP → hydroxysqualene

MQC87_RS16935: Lycopene_cycl
Domain 1 (5 - 399): Lycopene cyclase

Reactions:
  C40_carotenoid → C40_carotenoid

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.00 out of 20.97
Confidence: medium
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 23.51 out of 30.11
Confidence: medium
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.10 out of 26.85
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.64 out of 24.78
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16
Confidence: strong
Additional weak hits (20):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.92 out of 29.38
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 18.22 out of 29.25
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 20.75 out of 32.74
Confidence: weak
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 19.95 out of 27.55
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.26 out of 27.78
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 16.22 out of 28.14
Confidence: weak
DosR
Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 23.11 out of 29.51
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.12 out of 29.38
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 15.42 out of 28.14
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 20.26 out of 36.54
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 19.79 out of 30.97
Confidence: weak
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.94 out of 27.55
Confidence: weak
NrdR
Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 21.32 out of 27.18
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.94 out of 32.93
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.11 out of 32.93
Confidence: weak
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 13.76 out of 18.57
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 19.20 out of 26.12
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 17.82 out of 26.12
Confidence: weak
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 21.67 out of 29.72
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.65 out of 28.19
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
Terpene
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 192577 - 271015:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (mal) + (X) + (Val)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 192577 - 245281:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (mal) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 222944 - 266436:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X) + (Val)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 228666 - 271015:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X) + (Val)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
MQC87_RS16725: mal
PKS_AT (573..870): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 79.2%
  inactive: 70.8%
  2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 92.7
  inactive: 28.2
  Methoxymalonyl-CoA: 28.2
  Methylmalonyl-CoA: 24.2
  CHC-CoA: 12.8
  2-Methylbutyryl-CoA: 8.8
  Isobutyryl-CoA: 7.6
  fatty_acid: 6.0
  Propionyl-CoA: 5.6
  Ethylmalonyl-CoA: 1.8
  trans-1,2-CPDA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0

MQC87_RS16730: mxmal
PKS_AT (941..1182): mxmal
ATSignature: (unknown)
No matches above 50%
minowa: Methoxymalonyl-CoA

Prediction, score:
  Methoxymalonyl-CoA: 36.6
  Methylmalonyl-CoA: 30.3
  Propionyl-CoA: 23.8
  Malonyl-CoA: 21.6
  2-Methylbutyryl-CoA: 20.1
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Isobutyryl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  Ethylmalonyl-CoA: -1.7
  inactive: -3.9

MQC87_RS16810: X
AMP-binding (23..428): X
nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LAAAFSAALEEPEIVVGGDINVYGPTEATATASY
  Nearest Stachelhaus code(s):
    Arg DAEDVGVIGK (47% 8Å match)
  Stachelhaus code match:
    60% (weak)

MQC87_RS16825: Val
Search NORINE for peptide: strict or relaxed
AMP-binding (200..602): Val
nrpys: Val

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    val (Val)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LDPAFDASTLEAWLVAGGDTNGYGPTENTTFTTC
  Nearest Stachelhaus code(s):
    Val DALWLGGTFK (91% 8Å match)
    bOH-Val DALWLGGTFK (79% 8Å match)
  Stachelhaus code match:
    90% (moderate)

Link to PARAS substrate predictor
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
GFPP | Geranylfarnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
HPP | Hexaprenyl diphosphate
IPP | Isopentenyl diphosphate
PSPP | Presqualene diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CcpA | Catabolite control protein A
CelR | Cellobiose uptake repressor
LexA variant 2 | Repressor of DNA damage response
RutR | Regulator of the pyrimidine and purine metabolism

NZ_JALDPQ010000062.1 - Region 1 - ectoine
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 318,514 - 328,912 nt. (total: 10,399 nt) Show pHMM detection rules used
ectoine: ectoine_synt

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
MQC87_RS19290: NADH:flavin oxidoreductase/NADH oxidase

smcogs
  SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

Transferases: aminotransferase
MQC87_RS19280: aminotransferase class V

smcogs
  SMCOG1139: aminotransferase class V

MQC87_RS19310: aminotransferase class-III

smcogs
  SMCOG1013: aminotransferase class-III

MQC87_RS19320: aminotransferase class V

smcogs
  SMCOG1139: aminotransferase class V

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ectoine | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000853.3 |  | 0.92 | other (other) | ectoine | Streptomyces anulatus
BGC0002052.3 |  | 0.86 | other (ectoine) | ectoine | Streptomyces sp.
BGC0000852.5 |  | 0.70 | other (other) | ectoine | Sporosarcina pasteurii
BGC0000858.3 |  | 0.66 | other (other) | ectoine | Methylobacter marinus
BGC0000859.3 |  | 0.66 | other (other) | ectoine | Methylomicrobium alcaliphilum
BGC0000856.3 |  | 0.66 | other (other) | ectoine | Methylophaga thalassica
BGC0000855.3 |  | 0.66 | other (other) | ectoine | Methylomicrobium kenyense
BGC0000857.3 |  | 0.63 | other (other) | ectoine | Methylophaga alcalica
BGC0000860.3 |  | 0.63 | other (other) | ectoine | Methylarcula marina
BGC0000854.3 |  | 0.62 | other (other) | ectoine | Methylomicrobium alcaliphilum 20Z

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000853.3 |  | 0.92 | other (other) | ectoine | Streptomyces anulatus
BGC0002052.3 |  | 0.86 | other (ectoine) | ectoine | Streptomyces sp.
BGC0000852.5 |  | 0.70 | other (other) | ectoine | Sporosarcina pasteurii
BGC0000858.3 |  | 0.66 | other (other) | ectoine | Methylobacter marinus
BGC0000859.3 |  | 0.66 | other (other) | ectoine | Methylomicrobium alcaliphilum
BGC0000856.3 |  | 0.66 | other (other) | ectoine | Methylophaga thalassica
BGC0000855.3 |  | 0.66 | other (other) | ectoine | Methylomicrobium kenyense
BGC0000857.3 |  | 0.63 | other (other) | ectoine | Methylophaga alcalica
BGC0000860.3 |  | 0.63 | other (other) | ectoine | Methylarcula marina
BGC0000854.3 |  | 0.62 | other (other) | ectoine | Methylomicrobium alcaliphilum 20Z

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.62 out of 19.52
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.81 out of 27.55
Confidence: medium
Additional weak hits (6):
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.51 out of 27.78
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 17.04 out of 26.12
Confidence: weak
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.03 out of 19.26
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.75 out of 21.55
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.67 out of 28.14
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.18 out of 28.19
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsQ1 | Two-component system AfsQ1-Q2, activator of antibiotic production
GnfM | Regulator of nitrogen-fixation genes

NZ_JALDPQ010000063.1 - Region 1 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 78,261 - 119,391 nt. (total: 41,131 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxygenase
MQC87_RS20120: cytochrome P450

smcogs
  SMCOG1007: cytochrome P450

MQC87_RS20155: alcohol dehydrogenase

smcogs
  SMCOG1040: alcohol dehydrogenase

Transferases: kinase
MQC87_RS20195: PfkB domain protein

smcogs
  SMCOG1276: PfkB domain protein

Hydrolases: protease
MQC87_RS20130: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Ligases: synthase
MQC87_RS20125: chalcone and stilbene synthase domain protein

smcogs
  SMCOG1024: chalcone and stilbene synthase domain protein

MQC87_RS20200: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs
  SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

MQC87_RS20205: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001310.5 |  | 0.83 | PKS | naringenin | Streptomyces clavuligerus ATCC 27064
BGC0002127.3 |  | 0.71 | PKS | flaviolin, 1,3,6,8-tetrahydroxynaphthalene | Streptomyces coelicolor A3(2)
BGC0000902.4 |  | 0.67 | PKS | flaviolin | Saccharopolyspora erythraea NRRL 2338
BGC0000285.5 |  | 0.61 | PKS, saccharide | flaviolin, flaviolin rhamnoside, 3,3'-diflaviolin | Saccharopolyspora erythraea
BGC0000280.5 |  | 0.53 | PKS | 2,4-diacetylphloroglucinol | Pseudomonas fluorescens
BGC0000281.3 |  | 0.52 | PKS | 2,4-diacetylphloroglucinol | Pseudomonas fluorescens
BGC0002711.2 |  | 0.51 | PKS | nostovalerolactone, 9-dehydronostovalerolactone | Nostoc punctiforme PCC 73102
BGC0002073.3 |  | 0.50 | NRPS | dehydroxynocardamine | Corynebacterium propinquum
BGC0002476.2 |  | 0.48 | NRPS | enterobactin | Escherichia coli str. K-12 substr. MG1655
BGC0001224.5 |  | 0.46 | other (other) | reductasporine | uncultured bacterium

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001310.5 |  | 0.83 | PKS | naringenin | Streptomyces clavuligerus ATCC 27064
BGC0002127.3 |  | 0.71 | PKS | flaviolin, 1,3,6,8-tetrahydroxynaphthalene | Streptomyces coelicolor A3(2)
BGC0000902.4 |  | 0.67 | PKS | flaviolin | Saccharopolyspora erythraea NRRL 2338
BGC0000285.5 |  | 0.61 | PKS, saccharide | flaviolin, flaviolin rhamnoside, 3,3'-diflaviolin | Saccharopolyspora erythraea
BGC0000280.5 |  | 0.53 | PKS | 2,4-diacetylphloroglucinol | Pseudomonas fluorescens
BGC0000281.3 |  | 0.52 | PKS | 2,4-diacetylphloroglucinol | Pseudomonas fluorescens
BGC0002711.2 |  | 0.51 | PKS | nostovalerolactone, 9-dehydronostovalerolactone | Nostoc punctiforme PCC 73102
BGC0002073.3 |  | 0.50 | NRPS | dehydroxynocardamine | Corynebacterium propinquum
BGC0002476.2 |  | 0.48 | NRPS | enterobactin | Escherichia coli str. K-12 substr. MG1655
BGC0001224.5 |  | 0.46 | other (other) | reductasporine | uncultured bacterium

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Location:
Identifier
Identity
Coverage
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.46 out of 23.05
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.21 out of 27.78
Confidence: medium
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 28.03 out of 36.53
Confidence: medium
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 21.78 out of 29.72
Confidence: medium
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.62 out of 19.52
Confidence: medium
Additional weak hits (21):
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.21 out of 30.22
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 17.38 out of 29.25
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 19.33 out of 30.97
Confidence: weak
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 18.99 out of 25.88
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 17.98 out of 31.73
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 14.78 out of 27.78
Confidence: weak
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.00 out of 27.55
Confidence: weak
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.73 out of 19.26
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.09 out of 28.14
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.16 out of 27.78
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.82 out of 26.06
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.13 out of 27.78
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.94 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.92 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.50 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 15.12 out of 26.06
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.31 out of 21.55
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.26 out of 28.19
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.33 out of 28.19
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 18.78 out of 35.63
Confidence: weak
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.76 out of 24.78
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsQ1 | Two-component system AfsQ1-Q2, activator of antibiotic production
AfsR | Pleiotropic regulatory for antibiotic production
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
DmdR1 | Iron(II)-dependent repressor
NtrC | Nitrogen regulatory protein C

NZ_JALDPQ010000063.1 - Region 2 - NRP-metallophore,NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 146,261 - 245,499 nt. (total: 99,239 nt) Show pHMM detection rules used
NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxygenase
MQC87_RS20430: lysine/ornithine N-monooxygenase

smcogs
  SMCOG1080: lysine/ornithine N-monooxygenase

MQC87_RS20595: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Hydrolases: esterase hydrolase
MQC87_RS20470: enterobactin/ferric enterobactin esterase

smcogs
  SMCOG1098: enterobactin/ferric enterobactin esterase

MQC87_RS20580: isochorismatase

smcogs
  SMCOG1027: isochorismatase

MQC87_RS20605: enterobactin/ferric enterobactin esterase

smcogs
  SMCOG1098: enterobactin/ferric enterobactin esterase

MQC87_RS20625: amidohydrolase

smcogs
  SMCOG1244: amidohydrolase

Lyases: dehydratase
MQC87_RS20425: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

Isomerases: isomerase
MQC87_RS20590: isochorismate synthase

smcogs
  SMCOG1018: isochorismate synthase

Ligases: ligase synthase
MQC87_RS20410: polyprenol-monophosphomannose synthase ppm1

smcogs
  SMCOG1123: polyprenol-monophosphomannose synthase ppm1

MQC87_RS20460: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

MQC87_RS20585: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

MQC87_RS20620: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRP-metallophore | NRPS | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | ---
BGC0000368.5 |  |  |  | 1.37 | NRPS | griseobactin | Streptomyces sp. ATCC 700974
BGC0001128.4 |  |  |  | 1.02 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  |  |  | 1.01 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0002286.3 |  |  |  | 1.00 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000325.5 |  |  |  | 0.97 | NRPS | coelichelin | Streptomyces coelicolor A3(2)
BGC0001641.4 |  |  |  | 0.95 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001240.4 |  |  |  | 0.93 | NRPS | serinocyclin A, serinocyclin B | Metarhizium robertsii
BGC0001166.5 |  |  |  | 0.92 | NRPS | HC-toxin | Alternaria jesenskae
BGC0000307.4 |  |  |  | 0.90 | NRPS | AbT1 | Aureobasidium pullulans
BGC0000401.5 |  |  |  | 0.88 | NRPS | paenibactin | Paenibacillus elgii B69

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000368.5 |  | 0.88 | NRPS | griseobactin | Streptomyces sp. ATCC 700974
BGC0000401.5 |  | 0.72 | NRPS | paenibactin | Paenibacillus elgii B69
BGC0001825.4 |  | 0.72 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0000325.5 |  | 0.71 | NRPS | coelichelin | Streptomyces coelicolor A3(2)
BGC0000343.5 |  | 0.71 | NRPS | enterobactin | Pseudomonas sp. J465
BGC0001132.4 |  | 0.71 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001185.5 |  | 0.71 | NRPS | bacillibactin | Bacillus velezensis FZB42
BGC0001833.4 |  | 0.70 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.4 |  | 0.70 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  | 0.69 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.16 out of 18.16
Confidence: strong
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 19.35 out of 20.47
Confidence: strong
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.92 out of 20.47
Confidence: medium
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.25 out of 20.47
Confidence: medium
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 32.36 out of 36.53
Confidence: strong
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 27.19 out of 36.53
Confidence: medium
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 29.30 out of 36.53
Confidence: medium
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 21.94 out of 27.04
Confidence: medium
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 21.63 out of 27.04
Confidence: medium
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 28.57 out of 36.53
Confidence: medium
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 29.74 out of 36.53
Confidence: medium
Additional weak hits (36):
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.67 out of 30.22
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 17.37 out of 28.14
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.25 out of 27.78
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.99 out of 26.06
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.42 out of 21.55
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 12.96 out of 26.06
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.91 out of 39.62
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 19.07 out of 33.73
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 20.68 out of 32.74
Confidence: weak
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.96 out of 25.75
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.95 out of 30.25
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.80 out of 21.55
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.28 out of 21.55
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.38 out of 28.19
Confidence: weak
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.59 out of 22.40
Confidence: weak
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.59 out of 22.40
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 23.24 out of 36.53
Confidence: weak
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 18.09 out of 25.88
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.69 out of 36.53
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 15.77 out of 29.38
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.24 out of 32.93
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.75 out of 32.93
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 18.86 out of 35.63
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 23.54 out of 36.53
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 20.07 out of 30.98
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.87 out of 20.01
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 26.60 out of 39.62
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 25.40 out of 36.53
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 21.24 out of 36.53
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 25.71 out of 36.53
Confidence: weak
RicR
Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.14 out of 32.93
Confidence: weak
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.26 out of 18.57
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 16.45 out of 29.25
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.73 out of 29.38
Confidence: weak
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.41 out of 25.75
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.29 out of 28.19
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 146260 - 245499:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (D-Fo-OH-Orn - D-Thr - OH-Orn) + (Arg - Thr)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
MQC87_RS20460: Fo-OH-Orn - Thr - OH-Orn
Search NORINE for peptide: strict or relaxed
AMP-binding (144..542): Fo-OH-Orn
nrpys: Fo-OH-Orn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Long positively charged side chain (Orn, Lys, Arg)
  Small clusters prediction:
    Orn and hydroxy-Orn specific (Orn, OH-Orn)
  Single AA prediction:
    orn (Orn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    RWQAFDISINELYLWCGGEYHGYGPAETTIGVSH
  Nearest Stachelhaus code(s):
    Fo-OH-Orn DINYWGGIGK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1625..2036): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LNTHFDFAVWEGNQIFGGEVNMYGITETTVHVTH
  Nearest Stachelhaus code(s):
    Thr DFWNIGMVHK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (3061..3459): OH-Orn
nrpys: OH-Orn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Long positively charged side chain (Orn, Lys, Arg)
  Small clusters prediction:
    Orn and hydroxy-Orn specific (Orn, OH-Orn)
  Single AA prediction:
    orn (Orn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    MNHVFDMSWEEWNVLLGGEYNLYGPTEYTINTLG
  Nearest Stachelhaus code(s):
    OH-Orn DMENLGLINK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

MQC87_RS20585: diOH-Bz
Search NORINE for peptide: strict or relaxed
AMP-binding (33..440): diOH-Bz
nrpys: diOH-Bz

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Small clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Single AA prediction:
    dhb (diOH-Bz)

Stachelhaus prediction details:
  Stachelhaus sequence:
    SGSLFPLSSPGGGLLVGGAQQVFGMAEGLVNYTR
  Nearest Stachelhaus code(s):
    diOH-Bz PLPGLGVVNK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

MQC87_RS20620: Arg - Thr
Search NORINE for peptide: strict or relaxed
AMP-binding (477..917): Arg
nrpys: Arg

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LGHAFDASWDPWDVVVGGEVNLYGPTETTVDAYY
  Nearest Stachelhaus code(s):
    Arg DADDVGLVDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1602..2010): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LATHFDFSVWEGNQVFGGEVNMYGITETTVHVSY
  Nearest Stachelhaus code(s):
    Thr DFWNVGMVHK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
DasR | N-acetylglucosamine dependent repressor
DmdR1 | Iron(II)-dependent repressor
VqsM | Regulator of quorum-sensing signalling systems

NZ_JALDPQ010000063.1 - Region 3 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 306,135 - 328,348 nt. (total: 22,214 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: cyclase hydratase
MQC87_RS21005: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

MQC87_RS21030: Terpene synthase/cyclase metal-binding domain protein

smcogs
  SMCOG1052: Terpene synthase/cyclase metal-binding domain protein

Ligases: ligase
MQC87_RS21000: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001181.4 |  | 0.83 | terpene | geosmin | Streptomyces coelicolor A3(2)
BGC0001746.3 |  | 0.75 | terpene | pristinol | Streptomyces pristinaespiralis ATCC 25486
BGC0001135.5 |  | 0.56 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001641.4 |  | 0.55 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  | 0.55 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001833.4 |  | 0.55 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002286.3 |  | 0.55 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  | 0.55 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4 |  | 0.55 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0000649.3 |  | 0.44 | terpene | carotenoid | Streptomyces griseus subsp. griseus NBRC 13350

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001181.4 |  | 0.83 | terpene | geosmin | Streptomyces coelicolor A3(2)
BGC0001746.3 |  | 0.75 | terpene | pristinol | Streptomyces pristinaespiralis ATCC 25486
BGC0001135.5 |  | 0.56 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001641.4 |  | 0.55 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  | 0.55 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001833.4 |  | 0.55 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002286.3 |  | 0.55 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  | 0.55 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4 |  | 0.55 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0000649.3 |  | 0.44 | terpene | carotenoid | Streptomyces griseus subsp. griseus NBRC 13350

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene |  | germacradienol | C15 | C1-C10 | OH
sesquiterpene |  | geosmin | C12 | C1-C10 | OH

Genes with terpene domains:
MQC87_RS21030: T1TS + T1TS
Domain 1 (2 - 326): Type 1 terpene synthase
Subtype: Geosmin synthase, N terminal domain

Reactions:
  FPP → germacradienol

Domain 2 (336 - 697): Type 1 terpene synthase
Subtype: Geosmin synthase, C terminal domain

Reactions:
  germacradienol → geosmin

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.02 out of 23.79
Confidence: medium
Additional weak hits (10):
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.75 out of 27.78
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 16.71 out of 31.73
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.75 out of 30.25
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 16.69 out of 27.78
Confidence: weak
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.26 out of 26.85
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.49 out of 29.38
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.82 out of 29.38
Confidence: weak
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.79 out of 22.40
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 23.14 out of 29.65
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.37 out of 28.19
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
FPP | Farnesyl diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
IolR | Regulator of the inositol catabolism

NZ_JALDPQ010000063.1 - Region 4 - butyrolactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 361,521 - 372,465 nt. (total: 10,945 nt) Show pHMM detection rules used
butyrolactone: AfsA

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
MQC87_RS21320: alcohol dehydrogenase

smcogs
  SMCOG1040: alcohol dehydrogenase

Transferases: methyltransferase
MQC87_RS21275: O-methyltransferase

smcogs
  SMCOG1042: O-methyltransferase

MQC87_RS21310: methyltransferase

smcogs
  SMCOG1089: methyltransferase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | butyrolactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000848.5 |  | 0.85 | other (other) | A-factor | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000849.4 |  | 0.83 | other (butyrolactone) | SCB1, SCB2, SCB3 | Streptomyces coelicolor A3(2)
BGC0000850.5 |  | 0.69 | other (other) | γ-butyrolactone | Streptomyces acidiscabies
BGC0002578.2 |  | 0.43 | other (other) | gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F | Streptomyces venezuelae ATCC 10712
BGC0001633.3 |  | 0.41 | other (other) | ketomemicin B3, ketomemicin B4 | Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0000393.5 |  | 0.38 | NRPS, PKS | myxoprincomide-c506 | Myxococcus xanthus DK 1622
BGC0000550.3 |  | 0.37 | ribosomal | salivaricin G32 | Streptococcus salivarius
BGC0000557.5 |  | 0.37 | ribosomal | streptococcin A-FF22 | Streptococcus pyogenes
BGC0000526.5 |  | 0.37 | ribosomal | macedocin | Streptococcus macedonicus
BGC0000189.4 |  | 0.37 | PKS | 3-(2'-hydroxy-3'-oxo-4'-methylpentyl)-indole, 3-(2'-hydroxy-3'-oxo-4'-methylhexyl)-indole, 3-(2'-acetoxy-3'-oxo-4'-methylpentyl)-indole, 3-(2'-acetoxy-3'-oxo-4'-methylhexyl)-indole | Xenorhabdus bovienii SS-2004

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000848.5 |  | 0.85 | other (other) | A-factor | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000849.4 |  | 0.83 | other (butyrolactone) | SCB1, SCB2, SCB3 | Streptomyces coelicolor A3(2)
BGC0000850.5 |  | 0.69 | other (other) | γ-butyrolactone | Streptomyces acidiscabies
BGC0002578.2 |  | 0.43 | other (other) | gaburedin A, gaburedin B, gaburedin C, gaburedin D, gaburedin E, gaburedin F | Streptomyces venezuelae ATCC 10712
BGC0001633.3 |  | 0.41 | other (other) | ketomemicin B3, ketomemicin B4 | Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0000393.5 |  | 0.38 | NRPS, PKS | myxoprincomide-c506 | Myxococcus xanthus DK 1622
BGC0000550.3 |  | 0.37 | ribosomal | salivaricin G32 | Streptococcus salivarius
BGC0000557.5 |  | 0.37 | ribosomal | streptococcin A-FF22 | Streptococcus pyogenes
BGC0000526.5 |  | 0.37 | ribosomal | macedocin | Streptococcus macedonicus
BGC0000189.4 |  | 0.37 | PKS | 3-(2'-hydroxy-3'-oxo-4'-methylpentyl)-indole, 3-(2'-hydroxy-3'-oxo-4'-methylhexyl)-indole, 3-(2'-acetoxy-3'-oxo-4'-methylpentyl)-indole, 3-(2'-acetoxy-3'-oxo-4'-methylhexyl)-indole | Xenorhabdus bovienii SS-2004

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
No hits above weak threshold.
Weak hits (3):
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 23.40 out of 36.53
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.15 out of 28.19
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.24 out of 29.65
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---

NZ_JALDPQ010000064.1 - Region 1 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 146,300 - 167,277 nt. (total: 20,978 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: deacetylase
MQC87_RS22345: polysaccharide deacetylase

smcogs
  SMCOG1235: polysaccharide deacetylase

Lyases: cyclase hydratase
MQC87_RS22325: Terpene synthase/cyclase metal-binding domain protein

smcogs
  SMCOG1052: Terpene synthase/cyclase metal-binding domain protein

MQC87_RS22355: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001866.4 |  | 0.29 | PKS | viriditoxin | Byssochlamys spectabilis
BGC0000518.3 |  | 0.28 | ribosomal | informatipeptin | Streptomyces viridochromogenes DSM 40736
BGC0002553.2 |  | 0.27 | other (other) | tunicamycin | Rathayibacter iranicus
BGC0000913.3 |  | 0.26 | other (other) | MK-8 | Enterobacter cloacae
BGC0000875.4 |  | 0.26 | other (nucleoside), saccharide | caprazamycin, caprazamycin aglycon | Streptomyces sp. MK730-62F2
BGC0002034.3 |  | 0.25 | other (other) | perquinoline A, perquinoline B, perquinoline C | Streptomyces sp. IB2014 016-6
BGC0000157.5 |  | 0.25 | PKS | tautomycetin | Streptomyces sp. CK4412
BGC0001190.3 |  | 0.24 | PKS | fusaric acid | Fusarium verticillioides 7600
BGC0000252.5 |  | 0.24 | PKS | nonactin | Streptomyces griseus subsp. griseus
BGC0000243.4 |  | 0.24 | PKS | nonactin, monactin, dinactin, trinactin, tetranactin | Streptomyces griseus subsp. griseus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001866.4 |  | 0.29 | PKS | viriditoxin | Byssochlamys spectabilis
BGC0000518.3 |  | 0.28 | ribosomal | informatipeptin | Streptomyces viridochromogenes DSM 40736
BGC0002553.2 |  | 0.27 | other (other) | tunicamycin | Rathayibacter iranicus
BGC0000913.3 |  | 0.26 | other (other) | MK-8 | Enterobacter cloacae
BGC0000875.4 |  | 0.26 | other (nucleoside), saccharide | caprazamycin, caprazamycin aglycon | Streptomyces sp. MK730-62F2
BGC0002034.3 |  | 0.25 | other (other) | perquinoline A, perquinoline B, perquinoline C | Streptomyces sp. IB2014 016-6
BGC0000157.5 |  | 0.25 | PKS | tautomycetin | Streptomyces sp. CK4412
BGC0001190.3 |  | 0.24 | PKS | fusaric acid | Fusarium verticillioides 7600
BGC0000252.5 |  | 0.24 | PKS | nonactin | Streptomyces griseus subsp. griseus
BGC0000243.4 |  | 0.24 | PKS | nonactin, monactin, dinactin, trinactin, tetranactin | Streptomyces griseus subsp. griseus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:
No product predictions
Genes with terpene domains:
MQC87_RS22325: T1TS
Domain 1 (1 - 305): Type 1 terpene synthase
Subtype: unknown
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.11 out of 19.52
Confidence: medium
Additional weak hits (13):
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 19.99 out of 27.55
Confidence: weak
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 17.99 out of 26.33
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.07 out of 26.06
Confidence: weak
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.67 out of 26.33
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 12.61 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.01 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 12.65 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.75 out of 26.06
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.11 out of 27.78
Confidence: weak
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 18.47 out of 26.33
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 20.42 out of 33.73
Confidence: weak
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.83 out of 32.93
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.
No acronyms to display
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsQ1 | Two-component system AfsQ1-Q2, activator of antibiotic production

NZ_JALDPQ010000064.1 - Region 2 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 383,678 - 404,721 nt. (total: 21,044 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: dehydratase
MQC87_RS23305: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthetase
MQC87_RS23340: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000673.3 |  | 0.53 | terpene | pimara-8(14),15-diene | Aspergillus nidulans FGSC A4
BGC0000948.5 |  | 0.45 | other (other) | α-galactosylceramide | Bacteroides fragilis NCTC 9343
BGC0000657.5 |  | 0.44 | terpene | 2-methylisoborneol | Pseudanabaena sp. dqh15
BGC0000677.5 |  | 0.41 | terpene | cyclooctatin | Streptomyces melanosporofaciens
BGC0000665.5 |  | 0.38 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0001485.4 |  | 0.36 | other (other) | chuangxinmycin | Actinoplanes tsinanensis
BGC0002309.2 |  | 0.36 | terpene | cattleyene | Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0001910.4 |  | 0.35 | terpene | cyslabdan A, cyslabdan B, cyslabdan C | Streptomyces cyslabdanicus
BGC0000678.5 |  | 0.35 | terpene | pentalenolactone | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000664.5 |  | 0.35 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000673.3 |  | 0.53 | terpene | pimara-8(14),15-diene | Aspergillus nidulans FGSC A4
BGC0000948.5 |  | 0.45 | other (other) | α-galactosylceramide | Bacteroides fragilis NCTC 9343
BGC0000657.5 |  | 0.44 | terpene | 2-methylisoborneol | Pseudanabaena sp. dqh15
BGC0000677.5 |  | 0.41 | terpene | cyclooctatin | Streptomyces melanosporofaciens
BGC0000665.5 |  | 0.38 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0001485.4 |  | 0.36 | other (other) | chuangxinmycin | Actinoplanes tsinanensis
BGC0002309.2 |  | 0.36 | terpene | cattleyene | Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0001910.4 |  | 0.35 | terpene | cyslabdan A, cyslabdan B, cyslabdan C | Streptomyces cyslabdanicus
BGC0000678.5 |  | 0.35 | terpene | pentalenolactone | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000664.5 |  | 0.35 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP
diterpene precursor |  | GGPP | C20 | acyclic | PP
sesterterpene precursor |  | GFPP | C25 | acyclic | PP
triterpene precursor |  | HPP | C30 | acyclic | PP

Genes with terpene domains:
MQC87_RS23340: PT_FPPS_like
Domain 1 (58 - 342): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: unknown

Reactions:
  IPP, DMAPP → FPP
  IPP, DMAPP → GGPP
  IPP, DMAPP → GFPP
  IPP, DMAPP → HPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.11 out of 23.79
Confidence: medium
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.86 out of 18.57
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.39 out of 19.26
Confidence: strong
Additional weak hits (4):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.03 out of 26.06
Confidence: weak
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.69 out of 20.97
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 19.43 out of 35.63
Confidence: weak
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 17.67 out of 24.78
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
GFPP | Geranylfarnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
HPP | Hexaprenyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
IolR | Regulator of the inositol catabolism
ToxT | Regulator of MSHA biosynthesis

NZ_JALDPQ010000064.1 - Region 3 - lanthipeptide-class-iii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 517,863 - 540,586 nt. (total: 22,724 nt) Show pHMM detection rules used
lanthipeptide-class-iii: (micKC and not PKS_KS)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: acetyltransferase aminotransferase
MQC87_RS23930: aminotransferase

smcogs
  SMCOG1019: aminotransferase

MQC87_RS23985: Chloramphenicol acetyltransferase

smcogs
  SMCOG1156: Chloramphenicol acetyltransferase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-iii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000496.5 |  | 0.89 | ribosomal | AmfS | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000553.3 |  | 0.72 | ribosomal | SRO15-2212 | Streptomyces filamentosus NRRL 15998
BGC0000551.5 |  | 0.66 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000513.3 |  | 0.61 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0000501.3 |  | 0.60 | ribosomal | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0000519.4 |  | 0.60 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000518.3 |  | 0.55 | ribosomal | informatipeptin | Streptomyces viridochromogenes DSM 40736
BGC0000546.3 |  | 0.54 | ribosomal | SAL-2242 | Streptomyces albidoflavus
BGC0001226.4 |  | 0.52 | ribosomal | streptocollin | Streptomyces collinus Tu 365
BGC0002700.2 |  | 0.51 | ribosomal | bacinapeptin | Bacillus nakamurai

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000496.5 |  | 0.89 | ribosomal | AmfS | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000553.3 |  | 0.72 | ribosomal | SRO15-2212 | Streptomyces filamentosus NRRL 15998
BGC0000551.5 |  | 0.66 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000513.3 |  | 0.61 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0000501.3 |  | 0.60 | ribosomal | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0000519.4 |  | 0.60 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000518.3 |  | 0.55 | ribosomal | informatipeptin | Streptomyces viridochromogenes DSM 40736
BGC0000546.3 |  | 0.54 | ribosomal | SAL-2242 | Streptomyces albidoflavus
BGC0001226.4 |  | 0.52 | ribosomal | streptocollin | Streptomyces collinus Tu 365
BGC0002700.2 |  | 0.51 | ribosomal | bacinapeptin | Bacillus nakamurai

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for MQC87_RS23970

MQC87_RS23965
Leader:
MALLDLQAMDTPAEDSFGELAT
Core:
G S Q V S L L V C E Y S S L S V V L C T P
Core with dehydrations:
G Dha Q V Dha L L V Cys E Y Dha Dha L Dha V V L Cys Dhb P

#### antiSMASH-DB 4.0 matches for MQC87_RS23965

100.0%
NC_010572.1 and 60 others:
NC_021177.1 Lanthipeptides: SFUL_RS24355_lanthipeptide NZ_AQRK01000102.1 Lanthipeptides: YUW_RS30025_lanthipeptide NZ_ARPF01000003.1 Lanthipeptides: B083_RS0107255_lanthipeptide NZ_BMRY01000001.1 Lanthipeptides: IE140_RS02070_lanthipeptide NZ_BMSP01000003.1 Lanthipeptides: IE150_RS06495_lanthipeptide NZ_BMSZ01000003.1 Lanthipeptides: IE135_RS07550_lanthipeptide NZ_BMTW01000017.1 Lanthipeptides: IE134_RS28550_lanthipeptide NZ_BMUG01000009.1 Lanthipeptides: IE264_RS25430_lanthipeptide NZ_BMVK01000002.1 Lanthipeptides: IE272_RS07115_lanthipeptide NZ_BNBJ01000002.1 Lanthipeptides: IE304_RS05195_lanthipeptide NZ_CM003601.1 Lanthipeptides: JI76_RS25200_lanthipeptide NZ_CP010833.1 Lanthipeptides: TK78_RS10875_lanthipeptide NZ_CP011522.1 Lanthipeptides: ABE83_RS11805_lanthipeptide NZ_CP013738.1 Lanthipeptides: WQO_RS23525_lanthipeptide NZ_CP015362.1 Lanthipeptides: A6E92_RS09975_lanthipeptide NZ_CP020563.1 Lanthipeptides: B7C62_RS24450_lanthipeptide NZ_CP020570.1 Lanthipeptides: B1H20_RS34690_lanthipeptide NZ_CP024957.1 Lanthipeptides: CVT27_RS22730_lanthipeptide NZ_CP029361.1 Lanthipeptides: DIJ69_RS10225_lanthipeptide NZ_CP030930.1 Lanthipeptides: DTW94_RS22865_lanthipeptide NZ_CP061072.1 Lanthipeptides: HYC88_RS10560_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS24895_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS29435_lanthipeptide NZ_CP086102.1 Lanthipeptides: LK895_RS11660_lanthipeptide NZ_CP090837.1 Lanthipeptides: LZ559_RS24025_lanthipeptide NZ_CP096281.1 Lanthipeptides: MWG59_RS25685_lanthipeptide NZ_CP101397.1 Lanthipeptides: NLU04_RS06465_lanthipeptide NZ_CP110539.1 Lanthipeptides: OH133_RS12690_lanthipeptide NZ_CP112880.1 Lanthipeptides: N7925_RS11185_lanthipeptide NZ_CP113262.1 Lanthipeptides: OUQ49_RS22935_lanthipeptide NZ_CP117709.1 Lanthipeptides: PSQ21_RS24530_lanthipeptide NZ_DS999644.1 Lanthipeptides: SSGG_RS09925_lanthipeptide NZ_GL877172.1 Lanthipeptides: SACT1_RS12960_lanthipeptide NZ_JAAWWP010000002.1 Lanthipeptides: HFV08_RS04115_lanthipeptide NZ_JAGGOV010000004.1 Lanthipeptides: J7E92_RS02930_lanthipeptide NZ_JAHHWT010000009.1 Lanthipeptides: KM153_RS24430_lanthipeptide NZ_JALDPQ010000064.1 Lanthipeptides: MQC87_RS23965_lanthipeptide NZ_JAMFLF010000002.1 Lanthipeptides: M1212_RS07295_lanthipeptide NZ_JANRMN010000004.1 Lanthipeptides: NW249_RS08610_lanthipeptide NZ_JNLT01000003.1 Lanthipeptides: CD02_RS0108685_lanthipeptide NZ_KB890925.1 Lanthipeptides: B053_RS0113845_lanthipeptide NZ_KL573549.1 Lanthipeptides: BG84_RS0119125_lanthipeptide NZ_KQ257779.1 Lanthipeptides: IQ60_RS22540_lanthipeptide NZ_KZ195572.1 Lanthipeptides: B9W61_RS11940_lanthipeptide NZ_KZ679082.1 Lanthipeptides: C6W96_RS24050_lanthipeptide NZ_KZ819154.1 Lanthipeptides: DBP12_RS10285_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS23960_lanthipeptide NZ_KZ819182.1 Lanthipeptides: DBP21_RS24660_lanthipeptide NZ_LACR01000009.1 Lanthipeptides: YW5_RS12280_lanthipeptide NZ_LIPB01000001.1 Lanthipeptides: AMK17_RS03280_lanthipeptide NZ_LIPE01000001.1 Lanthipeptides: AMK12_RS03355_lanthipeptide NZ_LIVT01000001.1 Lanthipeptides: AMK24_RS01700_lanthipeptide NZ_LIVW01000001.1 Lanthipeptides: AMK28_RS03165_lanthipeptide NZ_LIXK01000001.1 Lanthipeptides: AMK23_RS04085_lanthipeptide NZ_LMEL01000012.1 Lanthipeptides: ASD29_RS10010_lanthipeptide NZ_LZRD01000054.1 Lanthipeptides: A3Q37_RS33745_lanthipeptide NZ_ML123117.1 Lanthipeptides: EES46_RS10300_lanthipeptide NZ_NNBN01000004.1 Lanthipeptides: CG717_RS12310_lanthipeptide NZ_VEHK01000004.1 Lanthipeptides: FS984_RS13530_lanthipeptide NZ_WWGD01000029.1 Lanthipeptides: GTY72_RS23245_lanthipeptide
Lanthipeptides: SGR_RS11800_lanthipeptide
1
G S Q V S L L V C E Y S S L S V V L C T P
21
G S Q V S L L V C E Y S S L S V V L C T P
1
G S Q V S L L V C E Y S S L S V V L C T P
21
95.2%
NZ_BDHJ01000008.1 and 4 others:
NZ_CP032543.1 Lanthipeptides: D6270_RS22715_lanthipeptide NZ_CP076457.1 Lanthipeptides: KME66_RS09945_lanthipeptide NZ_CP077652.1 Lanthipeptides: KRR37_RS22855_lanthipeptide NZ_WUEJ01000001.1 Lanthipeptides: GRQ63_RS04560_lanthipeptide
Lanthipeptides: BHQ08_RS03045_lanthipeptide
1
G S Q V S L L V C E Y S S L S V V L C T P
21
G S Q V S L L V C E Y S S L S V L C T P
1
G S Q V S L L V C E Y S S L S V T L C T P
21
95.2%
NZ_CP010519.1 and 1 other:
NZ_CP092644.1 Lanthipeptides: MID12_RS21330_lanthipeptide
Lanthipeptides: SLNWT_RS22370_lanthipeptide
1
G S Q V S L L V C E Y S S L S V V L C T P
21
G S Q V S L L V C E Y S S L S V V L C+P
1
G S Q V S L L V C E Y S S L S V V L C S P
21
with 77 more sequence matches
Only the first 10 are displayed here.
95.2%
NZ_CP045178.1:
Lanthipeptides: GBW32_RS28450_lanthipeptide
1
G S Q V S L L V C E Y S S L S V V L C T P
21
G S Q V S L L+C E Y S S L S V V L C T P
1
G S Q V S L L I C E Y S S L S V V L C T P
21
95.2%
NZ_CP054926.1 and 11 others:
NZ_CP068598.1 Lanthipeptides: IFE09_RS23820_lanthipeptide NZ_CP071044.1 Lanthipeptides: JHY03_RS23495_lanthipeptide NZ_CP080029.1 Lanthipeptides: KZO11_RS24935_lanthipeptide NZ_JAJUKK010000008.1 Lanthipeptides: LXH09_RS27635_lanthipeptide NZ_JOJC01000009.1 Lanthipeptides: IO23_RS0108435_lanthipeptide NZ_KB891296.1 Lanthipeptides: B061_RS0103425_lanthipeptide NZ_KZ268499.1 Lanthipeptides: CE422_RS23450_lanthipeptide NZ_KZ819159.1 Lanthipeptides: DBP19_RS22830_lanthipeptide NZ_LR881952.1 Lanthipeptides: STRPST75_RS10975_lanthipeptide NZ_LZQS01000001.1 Lanthipeptides: STIB_RS05225_lanthipeptide NZ_RCOL01000001.1 Lanthipeptides: STAN_RS24840_lanthipeptide
Lanthipeptides: HUT09_RS23550_lanthipeptide
1
G S Q V S L L V C E Y S S L S V V L C T P
21
G S Q V S L L V C E+S S L S V V L C T P
1
G S Q V S L L V C E F S S L S V V L C T P
21
95.2%
NZ_CP058556.1 and 5 others:
NZ_CP059898.1 Lanthipeptides: H3V39_RS22935_lanthipeptide NZ_CP070242.1 Lanthipeptides: I6J39_RS23755_lanthipeptide NZ_CP070260.1 Lanthipeptides: I6J40_RS10935_lanthipeptide NZ_JAJDST010000047.1 Lanthipeptides: LJC81_RS16960_lanthipeptide NZ_WWGL01000003.1 Lanthipeptides: GTY38_RS03410_lanthipeptide
Lanthipeptides: HXS80_RS11105_lanthipeptide
1
G S Q V S L L V C E Y S S L S V V L C T P
21
G S Q V S+L V C E Y S S L S V V L C T P
1
G S Q V S V L V C E Y S S L S V V L C T P
21
90.5%
NZ_CM001165.1 and 4 others:
NZ_CP021118.1 Lanthipeptides: CAC01_RS28155_lanthipeptide NZ_CP049945.1 Lanthipeptides: G9U55_RS17850_lanthipeptide NZ_CP119149.1 Lanthipeptides: P0D76_RS02270_lanthipeptide NZ_RWGV01000033.1 Lanthipeptides: EJA11_RS20985_lanthipeptide
Lanthipeptides: STTU_RS29395_lanthipeptide
1
G S Q V S L L V C E Y S S L S V V L C T P
21
G S Q V S L L+C E Y S S L S V L C T P
1
G S Q V S L L I C E Y S S L S V T L C T P
21
85.7%
NC_020990.1 and 26 others:
NZ_AMPN02000002.1 Lanthipeptides: SM8_RS12785_lanthipeptide NZ_AP025692.1 Lanthipeptides: MTP06_RS18190_lanthipeptide NZ_CM002273.1 Lanthipeptides: B590_RS12280_lanthipeptide NZ_CP009802.1 Lanthipeptides: SFR_RS12925_lanthipeptide NZ_CP014485.1 Lanthipeptides: Salbus254_RS12710_lanthipeptide NZ_CP016824.1 Lanthipeptides: BEN82_RS18165_lanthipeptide NZ_CP026490.1 Lanthipeptides: C3K23_RS19520_lanthipeptide NZ_CP031742.1 Lanthipeptides: D0C37_RS13445_lanthipeptide NZ_CP047147.1 Lanthipeptides: GR131_RS18520_lanthipeptide NZ_CP053539.1 Lanthipeptides: HN026_RS11800_lanthipeptide NZ_CP056773.1 Lanthipeptides: HWN34_RS12245_lanthipeptide NZ_CP063844.1 Lanthipeptides: IPZ55_RS12410_lanthipeptide NZ_CP064783.1 Lanthipeptides: IT782_RS12060_lanthipeptide NZ_CP076385.1 Lanthipeptides: KNZ81_RS12450_lanthipeptide NZ_CP079112.1 Lanthipeptides: STALF2_RS18135_lanthipeptide NZ_CP091820.1 Lanthipeptides: L2I08_RS02835_lanthipeptide NZ_CP106650.1 Lanthipeptides: B591_RS12385_lanthipeptide NZ_CP113103.1 Lanthipeptides: OSU72_RS17905_lanthipeptide NZ_JAHUVY010000001.1 Lanthipeptides: STALF3_RS17905_lanthipeptide NZ_JALLPQ010000001.1 Lanthipeptides: MWG58_RS12385_lanthipeptide NZ_KB890715.1 Lanthipeptides: B048_RS0115750_lanthipeptide NZ_KN549183.1 Lanthipeptides: D076_RS30740_lanthipeptide NZ_KZ195583.1 Lanthipeptides: B9W68_RS12440_lanthipeptide NZ_MNPQ01000004.1 Lanthipeptides: BGV78_RS11170_lanthipeptide NZ_OX371412.1 Lanthipeptides: OZE77_RS18215_lanthipeptide NZ_VOGX01000092.1 Lanthipeptides: FRZ02_RS31600_lanthipeptide
Lanthipeptides: XNR_RS11575_lanthipeptide
1
G S Q V S L L V C E Y S S L S V V L C T P
21
G S Q+S L L+C E Y S S L S V L C T P
1
G S Q I S L L I C E Y S S L S V T L C T P
21
85.7%
NZ_AQRJ01000051.1 and 1 other:
NZ_LFBV01000002.1 Lanthipeptides: AB852_RS09920_lanthipeptide
Lanthipeptides: YW7_RS14945_lanthipeptide
1
G S Q V S L L V C E Y S S L S V V L C T P
21
G S Q V S L+V C E Y S S L S +L C T P
1
G S Q V S L I V C E Y S S L S A L L C T P
21
85.7%
NZ_CP045702.1:
Lanthipeptides: F0344_RS33200_lanthipeptide
1
G S Q V S L L V C E Y S S L S V V L C T P
21
G S Q V S L L V C E+S S L S+ L C T P
1
G S Q V S L L V C E H S S L S L T L C T P
21
85.7%
NZ_ML123034.1:
Lanthipeptides: EES43_RS19795_lanthipeptide
1
G S Q V S L L V C E Y S S L S V V L C T P
21
G S Q V S L L+C E+S S L S V L C T P
1
G S Q V S L L I C E F S S L S V T L C T P
21
81.0%
NZ_LWLE01000019.1:
Lanthipeptides: A6A29_RS44250_lanthipeptide
1
G S Q V S L L V C E Y S S L S V V L C T P
21
G S Q V S L L+C E+S S L S+ L C T P
1
G S Q V S L L I C E H S S L S L T L C T P
21
61.9%
NZ_QGGR01000008.1:
Lanthipeptides: BC793_RS19230_lanthipeptide
1
G S Q V S L L V C E Y S S L S V V L C T
20
G S Q S L L+C S S L S V C
2
G S Q A S L L L C G D S S L S V T T C N
21

#### MIBiG 4.0 matches for MQC87_RS23965

95.5%
BGC0000553.3 (SSGG_RS09925):
Lanthipeptide: SRO15-2212
1
G S Q V S L L V C E Y S S L S V V L C T P
21
G S Q V S L L V C E Y S S L S V V L C T P
2
G S Q V S L L V C E Y S S L S V V L C T P
22

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 18.51 out of 25.31
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.11 out of 23.79
Confidence: medium
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.92 out of 20.47
Confidence: medium
Additional weak hits (10):
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.20 out of 21.55
Confidence: weak
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 17.99 out of 25.31
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.91 out of 20.01
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 19.59 out of 33.73
Confidence: weak
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.11 out of 25.75
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 15.78 out of 29.38
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.19 out of 29.38
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.29 out of 32.93
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.12 out of 28.14
Confidence: weak
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.79 out of 22.40
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

MQC87_RS23965 - Class III
  Cleavage pHMM score: 31.80
  RODEO score: 0
  Monoisotopic mass: 2075.1 Da
  Molecular weight: 2076.4 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2094.4 Da N = 1
    2112.4 Da N = 2
    2130.5 Da N = 3
    2148.5 Da N = 4

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CatR | H2O2-responsive repressor
IolR | Regulator of the inositol catabolism
VqsM | Regulator of quorum-sensing signalling systems

NZ_JALDPQ010000064.1 - Region 4 - NRPS-like,T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 604,093 - 658,864 nt. (total: 54,772 nt) Show pHMM detection rules used
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase reductase
MQC87_RS24365: dihydropteridine reductase

smcogs
  SMCOG1159: dihydropteridine reductase

MQC87_RS24425: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

MQC87_RS24490: alkyl hydroperoxide reductase/ Thiol specific

smcogs
  SMCOG1196: alkyl hydroperoxide reductase/ Thiol specific

Transferases: aminotransferase
MQC87_RS24410: aminotransferase class-III

smcogs
  SMCOG1013: aminotransferase class-III

Hydrolases: dehalogenase esterase
MQC87_RS24325: haloalkane dehalogenase

smcogs
  SMCOG1262: haloalkane dehalogenase

MQC87_RS24420: thioesterase

smcogs
  SMCOG1004: thioesterase

Lyases: lyase
MQC87_RS24440: argininosuccinate lyase/adenylosuccinate lyase

smcogs
  SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Ligases: ligase synthase
MQC87_RS24405: Beta-ketoacyl synthase

smcogs
  SMCOG1093: Beta-ketoacyl synthase

MQC87_RS24430: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Translocases: permease
MQC87_RS24350: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T1PKS | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001249.5 |  |  | 0.82 | NRPS | dimethylcoprogen | Alternaria alternata
BGC0001132.4 |  |  | 0.70 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002286.3 |  |  | 0.69 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002164.2 |  |  | 0.69 | NRPS | peramine | Epichloe festucae
BGC0001128.4 |  |  | 0.69 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001261.3 |  |  | 0.68 | NRPS | AM-toxin | Alternaria alternata
BGC0001135.5 |  |  | 0.68 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001641.4 |  |  | 0.66 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001276.3 |  |  | 0.65 | PKS | 6-methylsalicyclic acid | Aspergillus terreus
BGC0001273.3 |  |  | 0.65 | PKS | asperlactone | Aspergillus ochraceus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001249.5 |  | 0.73 | NRPS | dimethylcoprogen | Alternaria alternata
BGC0001132.4 |  | 0.68 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002286.3 |  | 0.68 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002164.2 |  | 0.67 | NRPS | peramine | Epichloe festucae
BGC0001128.4 |  | 0.67 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001261.3 |  | 0.67 | NRPS | AM-toxin | Alternaria alternata
BGC0001135.5 |  | 0.67 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001641.4 |  | 0.66 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001276.3 |  | 0.66 | PKS | 6-methylsalicyclic acid | Aspergillus terreus
BGC0001273.3 |  | 0.66 | PKS | asperlactone | Aspergillus ochraceus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.89 out of 23.79
Confidence: medium
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 26.88 out of 36.53
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.91 out of 23.79
Confidence: medium
Additional weak hits (7):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.83 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 13.67 out of 26.06
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.25 out of 20.01
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 16.61 out of 29.38
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 15.36 out of 27.78
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 17.11 out of 31.73
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.92 out of 28.19
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 4, location 604092 - 658864:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (mal) + (aThr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 5, location 604092 - 647389:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (mal) + (aThr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 6, location 616206 - 658864:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (mal) + (aThr)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
MQC87_RS24405: mal
PKS_AT (554..851): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 75.0%
  inactive: 58.3%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 131.5
  inactive: 79.0
  Methylmalonyl-CoA: 57.3
  Methoxymalonyl-CoA: 56.7
  Isobutyryl-CoA: 43.8
  Ethylmalonyl-CoA: 38.7
  CHC-CoA: 30.5
  Propionyl-CoA: 28.6
  Benzoyl-CoA: 23.5
  fatty_acid: 21.8
  Acetyl-CoA: 17.4
  trans-1,2-CPDA: 14.9
  2-Methylbutyryl-CoA: 14.9
  3-Methylbutyryl-CoA: 11.8

MQC87_RS24430: aThr
Search NORINE for peptide: strict or relaxed
AMP-binding (302..687): aThr
nrpys: aThr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LAVHFDFSVWEGSQVLGGEVNMYGITETTVHVTA
  Nearest Stachelhaus code(s):
    aThr DFWSVGMVHK (94% 8Å match)
    Thr DFWSVGMVHK (91% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
DmdR1 | Iron(II)-dependent repressor
IolR | Regulator of the inositol catabolism

NZ_JALDPQ010000065.1 - Region 1 - lanthipeptide-class-ii,lanthipeptide-class-iii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 10,114 - 41,386 nt. (total: 31,273 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)
lanthipeptide-class-iii: (micKC and not PKS_KS)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
MQC87_RS27480: oxidoreductase

smcogs
  SMCOG1079: oxidoreductase

Hydrolases: protease
MQC87_RS27555: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase
MQC87_RS27495: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | lanthipeptide-class-iii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0002700.2 |  |  | 0.38 | ribosomal | bacinapeptin | Bacillus nakamurai
BGC0000551.5 |  |  | 0.37 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000496.5 |  |  | 0.37 | ribosomal | AmfS | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000525.5 |  |  | 0.37 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000519.4 |  |  | 0.35 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000501.3 |  |  | 0.35 | ribosomal | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0000518.3 |  |  | 0.35 | ribosomal | informatipeptin | Streptomyces viridochromogenes DSM 40736
BGC0000553.3 |  |  | 0.34 | ribosomal | SRO15-2212 | Streptomyces filamentosus NRRL 15998
BGC0002111.3 |  |  | 0.34 | ribosomal | andalusicin A, andalusicin B | Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0000513.3 |  |  | 0.32 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002700.2 |  | 0.51 | ribosomal | bacinapeptin | Bacillus nakamurai
BGC0000551.5 |  | 0.50 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000496.5 |  | 0.50 | ribosomal | AmfS | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000525.5 |  | 0.50 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000519.4 |  | 0.49 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000501.3 |  | 0.49 | ribosomal | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0000518.3 |  | 0.49 | ribosomal | informatipeptin | Streptomyces viridochromogenes DSM 40736
BGC0000553.3 |  | 0.48 | ribosomal | SRO15-2212 | Streptomyces filamentosus NRRL 15998
BGC0002111.3 |  | 0.48 | ribosomal | andalusicin A, andalusicin B | Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0000513.3 |  | 0.47 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for MQC87_RS27495

MQC87_RS27525
Leader:
MSENTQPADDANETPEVEAHSVLDLQETSVQGG
MQC87_RS27525
Leader:
MSENTQPADDANETPEVEAHSVLDLQETSVQGG
Shared core:
D T T D G N C I S V L S V V E S Q R
Core with dehydrations:
D Dhb Dhb D G N Cys I Dha V L Dha V V E Dha Q R

#### antiSMASH-DB 4.0 matches for MQC87_RS27525

100.0%
NZ_BNBJ01000007.1 and 21 others:
NZ_BNBJ01000007.1 Lanthipeptides: IE304_RS13825_lanthipeptide NZ_BNBJ01000007.1 Lanthipeptides: IE304_RS13825_lanthipeptide NZ_BNBJ01000007.1 Lanthipeptides: IE304_RS13825_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptide NZ_DS999644.1 Lanthipeptides: SSGG_RS37575_lanthipeptide NZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptide NZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptide NZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptide NZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptide NZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptide NZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptide NZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptide NZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptide NZ_KL573557.1 Lanthipeptides: BG84_RS1000000140065_lanthipeptide NZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptide NZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptide NZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptide NZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptide
Lanthipeptides: IE304_RS13825_lanthipeptide
1
D T T D G N C I S V L S V V E S Q R
18
D T T D G N C I S V L S V V E S Q R
1
D T T D G N C I S V L S V V E S Q R
18
94.4%
NZ_BMRY01000010.1 and 58 others:
NZ_BMRY01000010.1 Lanthipeptides: IE140_RS27680_lanthipeptide NZ_BMRY01000010.1 Lanthipeptides: IE140_RS27680_lanthipeptide NZ_BMRY01000010.1 Lanthipeptides: IE140_RS27680_lanthipeptide NZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptide NZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptide NZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptide NZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptide NZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptide NZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptide NZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptide NZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptide NZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptide NZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptide NZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptide NZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptide NZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptide NZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptide NZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptide NZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptide NZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptide NZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptide NZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptide NZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptide NZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptide NZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptide NZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptide NZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptide NZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptide NZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptide NZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptide NZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptide NZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptide NZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptide NZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptide NZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptide NZ_KZ679082.1 Lanthipeptides: allorf_2505302_2505508_lanthipeptide NZ_KZ679082.1 Lanthipeptides: allorf_2505302_2505508_lanthipeptide NZ_KZ679082.1 Lanthipeptides: allorf_2505302_2505508_lanthipeptide NZ_KZ819154.1 Lanthipeptides: allorf_5241449_5241619_lanthipeptide NZ_KZ819154.1 Lanthipeptides: allorf_5241449_5241619_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptide NZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptide NZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptide NZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptide NZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptide NZ_NNBN01000010.1 Lanthipeptides: CG717_RS33255_lanthipeptide NZ_NNBN01000010.1 Lanthipeptides: CG717_RS33255_lanthipeptide NZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptide NZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptide NZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptide NZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptide
Lanthipeptides: IE140_RS27680_lanthipeptide
1
D T T D G N C I S V L S V V E S Q R
18
D T T D G N C I S V L S V V E Q R
1
D T T D G N C I S V L S V V E Q Q R
18
78.9%
NZ_CP117709.1:
Lanthipeptides: PSQ21_RS10520_lanthipeptide
1
D T T D G N C I S V L S V V E S Q
17
D T D G N C I S V L S V V E+Q
1
D Q T D G N C I S V L S V V E T Q
17
with 13 more sequence matches
Only the first 10 are displayed here.
77.8%
NZ_LZRD01000043.1:
Lanthipeptides: A3Q37_RS37410_lanthipeptide
5
G N C I S V L S V V E S Q R
18
G N C I S V L S V V E S Q R
1
G N C I S V L S V V E S Q R
14
61.1%
NZ_BNBJ01000007.1 and 7 others:
NZ_CP079114.1 Lanthipeptides: KV381_RS11700_lanthipeptide NZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptide NZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptide NZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptide NZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptide NZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18750_lanthipeptide NZ_KL573557.1 Lanthipeptides: BG84_RS1000000140060_lanthipeptide
Lanthipeptides: IE304_RS13830_lanthipeptide
5
G N C I S V L S V V E S
16
G N C I S V L S V V E+
2
G N C I S V L S V V E N
13
57.9%
NZ_LZRD01000043.1:
Lanthipeptides: A3Q37_RS37415_lanthipeptide
2
T T D G N C I S V L S V V E S
16
G N C I S V L S V V E+
5
A P P G N C I S V L S V V E N
19
50.0%
NZ_LMFT01000038.1 and 1 other:
NZ_LMFT01000038.1 Lanthipeptides: ASD51_RS37395_lanthipeptide
Lanthipeptides: ASD51_RS37395_lanthipeptide
7
C I S V L S V V E
15
C I S V L S V V E
1
C I S V L S V V E
9
44.4%
NZ_CP119145.1:
Lanthipeptides: PZB75_RS01650_lanthipeptide
7
C I S V L S V V E S Q R
18
C+S V+S V V S+R
1
C V S V I S V V L S E R
12
37.5%
NZ_ML142907.1 and 1 other:
NZ_ML142907.1 Lanthipeptides: DN53_RS02460_lanthipeptide
Lanthipeptides: DN53_RS02460_lanthipeptide
1
D T T D G N C I S V L S V V E S
16
D T T+G+C S S+V S
7
D T T N G D C T S G T S I V I S
22
23.5%
NC_021177.1 and 9 others:
NC_021177.1 Lanthipeptides: SFUL_RS36595_lanthipeptide NZ_BMUG01000001.1 Lanthipeptides: IE264_RS01515_lanthipeptide NZ_BMUG01000001.1 Lanthipeptides: IE264_RS01515_lanthipeptide NZ_CP054926.1 Lanthipeptides: HUT09_RS11275_lanthipeptide NZ_CP054926.1 Lanthipeptides: HUT09_RS11275_lanthipeptide NZ_CP071044.1 Lanthipeptides: JHY03_RS11255_lanthipeptide NZ_CP071044.1 Lanthipeptides: JHY03_RS11255_lanthipeptide NZ_JOJC01000008.1 Lanthipeptides: IO23_RS1000000137100_lanthipeptide NZ_JOJC01000008.1 Lanthipeptides: IO23_RS1000000137100_lanthipeptide
Lanthipeptides: SFUL_RS36595_lanthipeptide
5
G N C I S V L S V V
14
G+C+S V L S V V
22
G S C V S V L S V V
31
22.2%
NZ_CP058552.1:
Lanthipeptides: HW560_RS06640_lanthipeptide
3
T D G N C I S V L S V
13
T D G N C+S ++
7
T D G N C V S T I T A
17
20.0%
NZ_BDHJ01000009.1 and 1 other:
NZ_CP076457.1 Lanthipeptides: KME66_RS23045_lanthipeptide
Lanthipeptides: BHQ08_RS34920_lanthipeptide
5
G N C I S V L S V V
14
G N C+S +S+V
19
G N C V S T V S L V
28
19.2%
NZ_BMLN01000009.1:
Lanthipeptides: IEX28_RS15335_lanthipeptide
3
T D G N C I S V L S V
13
T D G N C+ ++
7
T D G N C L K S I T A
17
MQC87_RS27530
Leader:
MSENTKPAADDANETPEVEAHSVLDLQETAVHGDRDIIAP
MQC87_RS27530
Leader:
MSENTKPAADDANETPEVEAHSVLDLQETAVHGDRDIIAP
Shared core:
P G N C I S V L S V V E N
Core with dehydrations:
P G N Cys I Dha V L Dha V V E N

#### antiSMASH-DB 4.0 matches for MQC87_RS27530

100.0%
NZ_BNBJ01000007.1 and 8 others:
NZ_CP079114.1 Lanthipeptides: KV381_RS11700_lanthipeptide NZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptide NZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptide NZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptide NZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptide NZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18750_lanthipeptide NZ_KL573557.1 Lanthipeptides: BG84_RS1000000140060_lanthipeptide NZ_LZRD01000043.1 Lanthipeptides: A3Q37_RS37415_lanthipeptide
Lanthipeptides: IE304_RS13830_lanthipeptide
1
P G N C I S V L S V V E N
13
P G N C I S V L S V V E N
1
P G N C I S V L S V V E N
13
69.2%
NZ_LMFT01000038.1 and 1 other:
NZ_LMFT01000038.1 Lanthipeptides: ASD51_RS37395_lanthipeptide
Lanthipeptides: ASD51_RS37395_lanthipeptide
4
C I S V L S V V E N
13
C I S V L S V V E
1
C I S V L S V V E G
10
61.1%
NZ_BMRY01000010.1 and 58 others:
NZ_BMRY01000010.1 Lanthipeptides: IE140_RS27680_lanthipeptide NZ_BMRY01000010.1 Lanthipeptides: IE140_RS27680_lanthipeptide NZ_BMRY01000010.1 Lanthipeptides: IE140_RS27680_lanthipeptide NZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptide NZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptide NZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptide NZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptide NZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptide NZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptide NZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptide NZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptide NZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptide NZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptide NZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptide NZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptide NZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptide NZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptide NZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptide NZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptide NZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptide NZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptide NZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptide NZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptide NZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptide NZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptide NZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptide NZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptide NZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptide NZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptide NZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptide NZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptide NZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptide NZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptide NZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptide NZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptide NZ_KZ679082.1 Lanthipeptides: allorf_2505302_2505508_lanthipeptide NZ_KZ679082.1 Lanthipeptides: allorf_2505302_2505508_lanthipeptide NZ_KZ679082.1 Lanthipeptides: allorf_2505302_2505508_lanthipeptide NZ_KZ819154.1 Lanthipeptides: allorf_5241449_5241619_lanthipeptide NZ_KZ819154.1 Lanthipeptides: allorf_5241449_5241619_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptide NZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptide NZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptide NZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptide NZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptide NZ_NNBN01000010.1 Lanthipeptides: CG717_RS33255_lanthipeptide NZ_NNBN01000010.1 Lanthipeptides: CG717_RS33255_lanthipeptide NZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptide NZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptide NZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptide NZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptide
Lanthipeptides: IE140_RS27680_lanthipeptide
2
G N C I S V L S V V E N
13
G N C I S V L S V V E
5
G N C I S V L S V V E Q
16
with 6 more sequence matches
61.1%
NZ_BNBJ01000007.1 and 22 others:
NZ_BNBJ01000007.1 Lanthipeptides: IE304_RS13825_lanthipeptide NZ_BNBJ01000007.1 Lanthipeptides: IE304_RS13825_lanthipeptide NZ_BNBJ01000007.1 Lanthipeptides: IE304_RS13825_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptide NZ_DS999644.1 Lanthipeptides: SSGG_RS37575_lanthipeptide NZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptide NZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptide NZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptide NZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptide NZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptide NZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptide NZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptide NZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptide NZ_KL573557.1 Lanthipeptides: BG84_RS1000000140065_lanthipeptide NZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptide NZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptide NZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptide NZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptide NZ_LZRD01000043.1 Lanthipeptides: A3Q37_RS37410_lanthipeptide
Lanthipeptides: IE304_RS13825_lanthipeptide
2
G N C I S V L S V V E N
13
G N C I S V L S V V E+
5
G N C I S V L S V V E S
16
57.9%
NZ_CP117709.1:
Lanthipeptides: PSQ21_RS10520_lanthipeptide
2
G N C I S V L S V V E N
13
G N C I S V L S V V E
5
G N C I S V L S V V E T
16
26.5%
NC_021177.1 and 9 others:
NC_021177.1 Lanthipeptides: SFUL_RS36595_lanthipeptide NZ_BMUG01000001.1 Lanthipeptides: IE264_RS01515_lanthipeptide NZ_BMUG01000001.1 Lanthipeptides: IE264_RS01515_lanthipeptide NZ_CP054926.1 Lanthipeptides: HUT09_RS11275_lanthipeptide NZ_CP054926.1 Lanthipeptides: HUT09_RS11275_lanthipeptide NZ_CP071044.1 Lanthipeptides: JHY03_RS11255_lanthipeptide NZ_CP071044.1 Lanthipeptides: JHY03_RS11255_lanthipeptide NZ_JOJC01000008.1 Lanthipeptides: IO23_RS1000000137100_lanthipeptide NZ_JOJC01000008.1 Lanthipeptides: IO23_RS1000000137100_lanthipeptide
Lanthipeptides: SFUL_RS36595_lanthipeptide
1
P G N C I S V L S V V
11
P G+C+S V L S V V
21
P G S C V S V L S V V
31
23.3%
NZ_BDHJ01000009.1 and 1 other:
NZ_CP076457.1 Lanthipeptides: KME66_RS23045_lanthipeptide
Lanthipeptides: BHQ08_RS34920_lanthipeptide
1
P G N C I S V L S V V
11
P G N C+S +S+V
18
P G N C V S T V S L V
28
19.2%
NZ_NBBB01000022.1 and 1 other:
NZ_NUOG01000083.1 Lanthipeptides: COE07_RS24905_lanthipeptide
Lanthipeptides: B6F67_RS25205_lanthipeptide
1
P G N C I S V L S V V E N
13
P G C ++ + E N
7
P G T C Q T L C R I T E N
19
17.9%
NZ_OCTY01000002.1:
Lanthipeptides: allorf_0865928_0866053_lanthipeptide
1
P G N C I S V L S V V
11
P G C+S +S +
10
P G K C V S H I S Y L
20
allorf_012354_012542
Leader:
MATSGHVDEDGM
Core:
R T A W H P I I G C H A H V M S K A R A R K G V K G P F G I D L C R R A P P A R T R R S G E N F H F
Core with dehydrations:
R Dhb A W H P I I G Cys H A H V M Dha K A R A R K G V K G P F G I D L Cys R R A P P A R Dhb R R Dha G E N F H F

#### antiSMASH-DB 4.0 matches for allorf_012354_012542

100.0%
NZ_JALDPQ010000065.1:
Lanthipeptides: allorf_012354_012542_lanthipeptide
1
R T A W H P I I G C H A H V M S K A R A R K G V K G P F G I D L C R R A P P A R T R R S G E N F H F
50
R T A W H P I I G C H A H V M S K A R A R K G V K G P F G I D L C R R A P P A R T R R S G E N F H F
1
R T A W H P I I G C H A H V M S K A R A R K G V K G P F G I D L C R R A P P A R T R R S G E N F H F
50
30.0%
NZ_CP013738.1:
Lanthipeptides: allorf_2654949_2655104_lanthipeptide
30
I D L C R R A P P A R T R R S G E N F H F
50
+D L C R P P A R T R E N F H F
1
L D L C R H P P P A R T P R G V E N F H F
21
28.0%
NZ_LIVT01000002.1:
Lanthipeptides: allorf_397934_398080_lanthipeptide
28
F G I D L C R R A P P A R T R R S G E N F H
49
F G+D L C R R+ P +T R G N F H
1
F G L D L C R R S S P G K T S R D G G N F H
22
with 5 more sequence matches
26.0%
NZ_LIVW01000002.1:
Lanthipeptides: allorf_0400297_0400458_lanthipeptide
30
I D L C R R A P P A R T R R S G E N F H
49
+D L C R P P A+T R++G E+F H
1
L D L C R H T P P A K T R Q N G E D F H
20
20.0%
NZ_CP051884.1:
Lanthipeptides: allorf_3276552_3276758_lanthipeptide
19
R A R K G V K G P F G I D L C R R A P P A R T R
42
R G V G P F G+ C R ++R
2
R C V C G V V G P F G L-F C R A T K E L Q S R
24
16.0%
NZ_CP063989.1:
Lanthipeptides: allorf_0194163_0194297_lanthipeptide
27
P F G I D L C R R A P P A R
40
P G L R R P P R
1
P I G S T L I R R L P P P R
14
16.0%
NZ_MUXN01000027.1:
Lanthipeptides: allorf_018463_018597_lanthipeptide
34
R R A P P A R T R R S G E N
47
R R A P R+R R G++
2
R R A P A G R S R R C G D D
15
14.0%
NZ_FPCC01000026.1:
Lanthipeptides: allorf_25741_25842_lanthipeptide
26
G P F G I D L C R R A P P A R T R R S G
45
P I+ C + R+R R+G
1
S P L A I N R C M K Q K T I R S R R A G
20
allorf_026695_026847
Leader:
MGNMGASGGFGRVRGRKMRAG
allorf_026695_026847
Leader:
MGNMGASGGFGRVRGRKMRAG
Shared core:
P R C A G A G P A A G S G R A Y G P L R R P S P F P E A R
Core with dehydrations:
P R Cys A G A G P A A G Dha G R A Y G P L R R P Dha P F P E A R

#### antiSMASH-DB 4.0 matches for allorf_026695_026847

100.0%
NZ_JALDPQ010000065.1 and 2 others:
NZ_JALDPQ010000065.1 Lanthipeptides: allorf_026695_026847_lanthipeptide NZ_JALDPQ010000065.1 Lanthipeptides: allorf_026695_026847_lanthipeptide
Lanthipeptides: allorf_026695_026847_lanthipeptide
1
P R C A G A G P A A G S G R A Y G P L R R P S P F P E A R
29
P R C A G A G P A A G S G R A Y G P L R R P S P F P E A R
1
P R C A G A G P A A G S G R A Y G P L R R P S P F P E A R
29
30.6%
NZ_CP020570.1 and 10 others:
NZ_CP020570.1 Lanthipeptides: allorf_2516141_2516284_lanthipeptide NZ_CP020570.1 Lanthipeptides: allorf_2516141_2516284_lanthipeptide NZ_CP058556.1 Lanthipeptides: allorf_5603706_5603849_lanthipeptide NZ_CP058556.1 Lanthipeptides: allorf_5603706_5603849_lanthipeptide NZ_CP058556.1 Lanthipeptides: allorf_5603706_5603849_lanthipeptide NZ_CP058556.1 Lanthipeptides: allorf_5603706_5603849_lanthipeptide NZ_CP059898.1 Lanthipeptides: allorf_2457020_2457163_lanthipeptide NZ_WWGL01000034.1 Lanthipeptides: allorf_1026403_1026546_lanthipeptide NZ_WWGL01000034.1 Lanthipeptides: allorf_1026403_1026546_lanthipeptide NZ_WWGL01000034.1 Lanthipeptides: allorf_1026403_1026546_lanthipeptide
Lanthipeptides: allorf_2516141_2516284_lanthipeptide
1
P R C A G A G P A A G S G R A Y G P L R R P
22
P R C A G G G R G R P
19
P R C A G V----G C G R T I G T C V R P
36
30.6%
NZ_CP070242.1 and 9 others:
NZ_CP070242.1 Lanthipeptides: allorf_2528027_2528170_lanthipeptide NZ_CP070242.1 Lanthipeptides: allorf_2528027_2528170_lanthipeptide NZ_CP070260.1 Lanthipeptides: allorf_5476524_5476667_lanthipeptide NZ_CP070260.1 Lanthipeptides: allorf_5476524_5476667_lanthipeptide NZ_CP070260.1 Lanthipeptides: allorf_5476524_5476667_lanthipeptide NZ_CP070260.1 Lanthipeptides: allorf_5476524_5476667_lanthipeptide NZ_JAJDST010000044.1 Lanthipeptides: allorf_029750_029893_lanthipeptide NZ_JAJDST010000044.1 Lanthipeptides: allorf_029750_029893_lanthipeptide NZ_JAJDST010000044.1 Lanthipeptides: allorf_029750_029893_lanthipeptide
Lanthipeptides: allorf_2528027_2528170_lanthipeptide
1
P R C A G A G P A A G S G R A Y G P L R R P
22
P R C A G G G R G R P
19
P R C A G V----G C G R T I G M C V R P
36
with 4 more sequence matches
20.5%
NC_014098.1:
Lanthipeptides: allorf_2904135_2904323_lanthipeptide
8
P A A G S G R A Y G P L R R P S P F
25
P G S G A G R P F
14
P T G G S G E A A G D C G R S E P F
31
18.6%
NZ_ML123085.1 and 3 others:
NZ_ML123085.1 Lanthipeptides: allorf_0381774_0381971_lanthipeptide NZ_RDBM01000037.1 Lanthipeptides: allorf_1275501_1275698_lanthipeptide NZ_RDBM01000037.1 Lanthipeptides: allorf_1275501_1275698_lanthipeptide
Lanthipeptides: allorf_0381774_0381971_lanthipeptide
20
R R P S P F P E A R
29
R R P S P E A R
34
R R P S P G Q E A R
43
18.2%
NC_021177.1 and 6 others:
NZ_BMUG01000001.1 Lanthipeptides: allorf_0358025_0358183_lanthipeptide NZ_BMUG01000001.1 Lanthipeptides: allorf_0358025_0358183_lanthipeptide NZ_CP054926.1 Lanthipeptides: allorf_2551449_2551640_lanthipeptide NZ_CP071044.1 Lanthipeptides: allorf_2560866_2561024_lanthipeptide NZ_JOJC01000008.1 Lanthipeptides: allorf_032194_032352_lanthipeptide NZ_JOJC01000008.1 Lanthipeptides: allorf_032194_032352_lanthipeptide
Lanthipeptides: allorf_2607385_2607543_lanthipeptide
21
R P S P F P E A R
29
R P S P P E A R
36
R P S P L P E A R
44
15.2%
NZ_CP098485.1:
Lanthipeptides: allorf_6386562_6386786_lanthipeptide
7
G P A A G S G R A Y-G P L R R P S P F
25
G P A G G A Y G +R R +
18
G P A G G C G E A Y R G T I R R N R T Y
37

#### Lanthipeptide(s) for MQC87_RS27515

MQC87_RS27525
Leader:
MSENTQPADDANETPEVEAHSVLDLQETSVQGG
MQC87_RS27525
Leader:
MSENTQPADDANETPEVEAHSVLDLQETSVQGG
Shared core:
D T T D G N C I S V L S V V E S Q R
Core with dehydrations:
D Dhb Dhb D G N Cys I Dha V L Dha V V E Dha Q R

#### antiSMASH-DB 4.0 matches for MQC87_RS27525

100.0%
NZ_BNBJ01000007.1 and 21 others:
NZ_BNBJ01000007.1 Lanthipeptides: IE304_RS13825_lanthipeptide NZ_BNBJ01000007.1 Lanthipeptides: IE304_RS13825_lanthipeptide NZ_BNBJ01000007.1 Lanthipeptides: IE304_RS13825_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptide NZ_DS999644.1 Lanthipeptides: SSGG_RS37575_lanthipeptide NZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptide NZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptide NZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptide NZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptide NZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptide NZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptide NZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptide NZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptide NZ_KL573557.1 Lanthipeptides: BG84_RS1000000140065_lanthipeptide NZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptide NZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptide NZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptide NZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptide
Lanthipeptides: IE304_RS13825_lanthipeptide
1
D T T D G N C I S V L S V V E S Q R
18
D T T D G N C I S V L S V V E S Q R
1
D T T D G N C I S V L S V V E S Q R
18
94.4%
NZ_BMRY01000010.1 and 58 others:
NZ_BMRY01000010.1 Lanthipeptides: IE140_RS27680_lanthipeptide NZ_BMRY01000010.1 Lanthipeptides: IE140_RS27680_lanthipeptide NZ_BMRY01000010.1 Lanthipeptides: IE140_RS27680_lanthipeptide NZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptide NZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptide NZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptide NZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptide NZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptide NZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptide NZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptide NZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptide NZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptide NZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptide NZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptide NZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptide NZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptide NZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptide NZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptide NZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptide NZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptide NZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptide NZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptide NZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptide NZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptide NZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptide NZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptide NZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptide NZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptide NZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptide NZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptide NZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptide NZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptide NZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptide NZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptide NZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptide NZ_KZ679082.1 Lanthipeptides: allorf_2505302_2505508_lanthipeptide NZ_KZ679082.1 Lanthipeptides: allorf_2505302_2505508_lanthipeptide NZ_KZ679082.1 Lanthipeptides: allorf_2505302_2505508_lanthipeptide NZ_KZ819154.1 Lanthipeptides: allorf_5241449_5241619_lanthipeptide NZ_KZ819154.1 Lanthipeptides: allorf_5241449_5241619_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptide NZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptide NZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptide NZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptide NZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptide NZ_NNBN01000010.1 Lanthipeptides: CG717_RS33255_lanthipeptide NZ_NNBN01000010.1 Lanthipeptides: CG717_RS33255_lanthipeptide NZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptide NZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptide NZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptide NZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptide
Lanthipeptides: IE140_RS27680_lanthipeptide
1
D T T D G N C I S V L S V V E S Q R
18
D T T D G N C I S V L S V V E Q R
1
D T T D G N C I S V L S V V E Q Q R
18
78.9%
NZ_CP117709.1:
Lanthipeptides: PSQ21_RS10520_lanthipeptide
1
D T T D G N C I S V L S V V E S Q
17
D T D G N C I S V L S V V E+Q
1
D Q T D G N C I S V L S V V E T Q
17
with 13 more sequence matches
Only the first 10 are displayed here.
77.8%
NZ_LZRD01000043.1:
Lanthipeptides: A3Q37_RS37410_lanthipeptide
5
G N C I S V L S V V E S Q R
18
G N C I S V L S V V E S Q R
1
G N C I S V L S V V E S Q R
14
61.1%
NZ_BNBJ01000007.1 and 7 others:
NZ_CP079114.1 Lanthipeptides: KV381_RS11700_lanthipeptide NZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptide NZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptide NZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptide NZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptide NZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18750_lanthipeptide NZ_KL573557.1 Lanthipeptides: BG84_RS1000000140060_lanthipeptide
Lanthipeptides: IE304_RS13830_lanthipeptide
5
G N C I S V L S V V E S
16
G N C I S V L S V V E+
2
G N C I S V L S V V E N
13
57.9%
NZ_LZRD01000043.1:
Lanthipeptides: A3Q37_RS37415_lanthipeptide
2
T T D G N C I S V L S V V E S
16
G N C I S V L S V V E+
5
A P P G N C I S V L S V V E N
19
50.0%
NZ_LMFT01000038.1 and 1 other:
NZ_LMFT01000038.1 Lanthipeptides: ASD51_RS37395_lanthipeptide
Lanthipeptides: ASD51_RS37395_lanthipeptide
7
C I S V L S V V E
15
C I S V L S V V E
1
C I S V L S V V E
9
44.4%
NZ_CP119145.1:
Lanthipeptides: PZB75_RS01650_lanthipeptide
7
C I S V L S V V E S Q R
18
C+S V+S V V S+R
1
C V S V I S V V L S E R
12
37.5%
NZ_ML142907.1 and 1 other:
NZ_ML142907.1 Lanthipeptides: DN53_RS02460_lanthipeptide
Lanthipeptides: DN53_RS02460_lanthipeptide
1
D T T D G N C I S V L S V V E S
16
D T T+G+C S S+V S
7
D T T N G D C T S G T S I V I S
22
23.5%
NC_021177.1 and 9 others:
NC_021177.1 Lanthipeptides: SFUL_RS36595_lanthipeptide NZ_BMUG01000001.1 Lanthipeptides: IE264_RS01515_lanthipeptide NZ_BMUG01000001.1 Lanthipeptides: IE264_RS01515_lanthipeptide NZ_CP054926.1 Lanthipeptides: HUT09_RS11275_lanthipeptide NZ_CP054926.1 Lanthipeptides: HUT09_RS11275_lanthipeptide NZ_CP071044.1 Lanthipeptides: JHY03_RS11255_lanthipeptide NZ_CP071044.1 Lanthipeptides: JHY03_RS11255_lanthipeptide NZ_JOJC01000008.1 Lanthipeptides: IO23_RS1000000137100_lanthipeptide NZ_JOJC01000008.1 Lanthipeptides: IO23_RS1000000137100_lanthipeptide
Lanthipeptides: SFUL_RS36595_lanthipeptide
5
G N C I S V L S V V
14
G+C+S V L S V V
22
G S C V S V L S V V
31
22.2%
NZ_CP058552.1:
Lanthipeptides: HW560_RS06640_lanthipeptide
3
T D G N C I S V L S V
13
T D G N C+S ++
7
T D G N C V S T I T A
17
20.0%
NZ_BDHJ01000009.1 and 1 other:
NZ_CP076457.1 Lanthipeptides: KME66_RS23045_lanthipeptide
Lanthipeptides: BHQ08_RS34920_lanthipeptide
5
G N C I S V L S V V
14
G N C+S +S+V
19
G N C V S T V S L V
28
19.2%
NZ_BMLN01000009.1:
Lanthipeptides: IEX28_RS15335_lanthipeptide
3
T D G N C I S V L S V
13
T D G N C+ ++
7
T D G N C L K S I T A
17
MQC87_RS27530
Leader:
MSENTKPAADDANETPEVEAHSVLDLQETAVHGDRDIIAP
MQC87_RS27530
Leader:
MSENTKPAADDANETPEVEAHSVLDLQETAVHGDRDIIAP
Shared core:
P G N C I S V L S V V E N
Core with dehydrations:
P G N Cys I Dha V L Dha V V E N

#### antiSMASH-DB 4.0 matches for MQC87_RS27530

100.0%
NZ_BNBJ01000007.1 and 8 others:
NZ_CP079114.1 Lanthipeptides: KV381_RS11700_lanthipeptide NZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptide NZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptide NZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptide NZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27530_lanthipeptide NZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18750_lanthipeptide NZ_KL573557.1 Lanthipeptides: BG84_RS1000000140060_lanthipeptide NZ_LZRD01000043.1 Lanthipeptides: A3Q37_RS37415_lanthipeptide
Lanthipeptides: IE304_RS13830_lanthipeptide
1
P G N C I S V L S V V E N
13
P G N C I S V L S V V E N
1
P G N C I S V L S V V E N
13
69.2%
NZ_LMFT01000038.1 and 1 other:
NZ_LMFT01000038.1 Lanthipeptides: ASD51_RS37395_lanthipeptide
Lanthipeptides: ASD51_RS37395_lanthipeptide
4
C I S V L S V V E N
13
C I S V L S V V E
1
C I S V L S V V E G
10
61.1%
NZ_BMRY01000010.1 and 58 others:
NZ_BMRY01000010.1 Lanthipeptides: IE140_RS27680_lanthipeptide NZ_BMRY01000010.1 Lanthipeptides: IE140_RS27680_lanthipeptide NZ_BMRY01000010.1 Lanthipeptides: IE140_RS27680_lanthipeptide NZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptide NZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptide NZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptide NZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptide NZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptide NZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptide NZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptide NZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptide NZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptide NZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptide NZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptide NZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptide NZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptide NZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptide NZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptide NZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptide NZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptide NZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptide NZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptide NZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptide NZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptide NZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptide NZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptide NZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptide NZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptide NZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptide NZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptide NZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptide NZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptide NZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptide NZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptide NZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptide NZ_KZ679082.1 Lanthipeptides: allorf_2505302_2505508_lanthipeptide NZ_KZ679082.1 Lanthipeptides: allorf_2505302_2505508_lanthipeptide NZ_KZ679082.1 Lanthipeptides: allorf_2505302_2505508_lanthipeptide NZ_KZ819154.1 Lanthipeptides: allorf_5241449_5241619_lanthipeptide NZ_KZ819154.1 Lanthipeptides: allorf_5241449_5241619_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptide NZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptide NZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptide NZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptide NZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptide NZ_NNBN01000010.1 Lanthipeptides: CG717_RS33255_lanthipeptide NZ_NNBN01000010.1 Lanthipeptides: CG717_RS33255_lanthipeptide NZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptide NZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptide NZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptide NZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptide
Lanthipeptides: IE140_RS27680_lanthipeptide
2
G N C I S V L S V V E N
13
G N C I S V L S V V E
5
G N C I S V L S V V E Q
16
with 6 more sequence matches
61.1%
NZ_BNBJ01000007.1 and 22 others:
NZ_BNBJ01000007.1 Lanthipeptides: IE304_RS13825_lanthipeptide NZ_BNBJ01000007.1 Lanthipeptides: IE304_RS13825_lanthipeptide NZ_BNBJ01000007.1 Lanthipeptides: IE304_RS13825_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptide NZ_DS999644.1 Lanthipeptides: SSGG_RS37575_lanthipeptide NZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptide NZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptide NZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptide NZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptide NZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptide NZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptide NZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptide NZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptide NZ_KL573557.1 Lanthipeptides: BG84_RS1000000140065_lanthipeptide NZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptide NZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptide NZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptide NZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptide NZ_LZRD01000043.1 Lanthipeptides: A3Q37_RS37410_lanthipeptide
Lanthipeptides: IE304_RS13825_lanthipeptide
2
G N C I S V L S V V E N
13
G N C I S V L S V V E+
5
G N C I S V L S V V E S
16
57.9%
NZ_CP117709.1:
Lanthipeptides: PSQ21_RS10520_lanthipeptide
2
G N C I S V L S V V E N
13
G N C I S V L S V V E
5
G N C I S V L S V V E T
16
26.5%
NC_021177.1 and 9 others:
NC_021177.1 Lanthipeptides: SFUL_RS36595_lanthipeptide NZ_BMUG01000001.1 Lanthipeptides: IE264_RS01515_lanthipeptide NZ_BMUG01000001.1 Lanthipeptides: IE264_RS01515_lanthipeptide NZ_CP054926.1 Lanthipeptides: HUT09_RS11275_lanthipeptide NZ_CP054926.1 Lanthipeptides: HUT09_RS11275_lanthipeptide NZ_CP071044.1 Lanthipeptides: JHY03_RS11255_lanthipeptide NZ_CP071044.1 Lanthipeptides: JHY03_RS11255_lanthipeptide NZ_JOJC01000008.1 Lanthipeptides: IO23_RS1000000137100_lanthipeptide NZ_JOJC01000008.1 Lanthipeptides: IO23_RS1000000137100_lanthipeptide
Lanthipeptides: SFUL_RS36595_lanthipeptide
1
P G N C I S V L S V V
11
P G+C+S V L S V V
21
P G S C V S V L S V V
31
23.3%
NZ_BDHJ01000009.1 and 1 other:
NZ_CP076457.1 Lanthipeptides: KME66_RS23045_lanthipeptide
Lanthipeptides: BHQ08_RS34920_lanthipeptide
1
P G N C I S V L S V V
11
P G N C+S +S+V
18
P G N C V S T V S L V
28
19.2%
NZ_NBBB01000022.1 and 1 other:
NZ_NUOG01000083.1 Lanthipeptides: COE07_RS24905_lanthipeptide
Lanthipeptides: B6F67_RS25205_lanthipeptide
1
P G N C I S V L S V V E N
13
P G C ++ + E N
7
P G T C Q T L C R I T E N
19
17.9%
NZ_OCTY01000002.1:
Lanthipeptides: allorf_0865928_0866053_lanthipeptide
1
P G N C I S V L S V V
11
P G C+S +S +
10
P G K C V S H I S Y L
20
allorf_026695_026847
Leader:
MGNMGASGGFGRVRGRKMRAG
allorf_026695_026847
Leader:
MGNMGASGGFGRVRGRKMRAG
Shared core:
P R C A G A G P A A G S G R A Y G P L R R P S P F P E A R
Core with dehydrations:
P R Cys A G A G P A A G Dha G R A Y G P L R R P Dha P F P E A R

#### antiSMASH-DB 4.0 matches for allorf_026695_026847

100.0%
NZ_JALDPQ010000065.1 and 2 others:
NZ_JALDPQ010000065.1 Lanthipeptides: allorf_026695_026847_lanthipeptide NZ_JALDPQ010000065.1 Lanthipeptides: allorf_026695_026847_lanthipeptide
Lanthipeptides: allorf_026695_026847_lanthipeptide
1
P R C A G A G P A A G S G R A Y G P L R R P S P F P E A R
29
P R C A G A G P A A G S G R A Y G P L R R P S P F P E A R
1
P R C A G A G P A A G S G R A Y G P L R R P S P F P E A R
29
30.6%
NZ_CP020570.1 and 10 others:
NZ_CP020570.1 Lanthipeptides: allorf_2516141_2516284_lanthipeptide NZ_CP020570.1 Lanthipeptides: allorf_2516141_2516284_lanthipeptide NZ_CP058556.1 Lanthipeptides: allorf_5603706_5603849_lanthipeptide NZ_CP058556.1 Lanthipeptides: allorf_5603706_5603849_lanthipeptide NZ_CP058556.1 Lanthipeptides: allorf_5603706_5603849_lanthipeptide NZ_CP058556.1 Lanthipeptides: allorf_5603706_5603849_lanthipeptide NZ_CP059898.1 Lanthipeptides: allorf_2457020_2457163_lanthipeptide NZ_WWGL01000034.1 Lanthipeptides: allorf_1026403_1026546_lanthipeptide NZ_WWGL01000034.1 Lanthipeptides: allorf_1026403_1026546_lanthipeptide NZ_WWGL01000034.1 Lanthipeptides: allorf_1026403_1026546_lanthipeptide
Lanthipeptides: allorf_2516141_2516284_lanthipeptide
1
P R C A G A G P A A G S G R A Y G P L R R P
22
P R C A G G G R G R P
19
P R C A G V----G C G R T I G T C V R P
36
30.6%
NZ_CP070242.1 and 9 others:
NZ_CP070242.1 Lanthipeptides: allorf_2528027_2528170_lanthipeptide NZ_CP070242.1 Lanthipeptides: allorf_2528027_2528170_lanthipeptide NZ_CP070260.1 Lanthipeptides: allorf_5476524_5476667_lanthipeptide NZ_CP070260.1 Lanthipeptides: allorf_5476524_5476667_lanthipeptide NZ_CP070260.1 Lanthipeptides: allorf_5476524_5476667_lanthipeptide NZ_CP070260.1 Lanthipeptides: allorf_5476524_5476667_lanthipeptide NZ_JAJDST010000044.1 Lanthipeptides: allorf_029750_029893_lanthipeptide NZ_JAJDST010000044.1 Lanthipeptides: allorf_029750_029893_lanthipeptide NZ_JAJDST010000044.1 Lanthipeptides: allorf_029750_029893_lanthipeptide
Lanthipeptides: allorf_2528027_2528170_lanthipeptide
1
P R C A G A G P A A G S G R A Y G P L R R P
22
P R C A G G G R G R P
19
P R C A G V----G C G R T I G M C V R P
36
with 4 more sequence matches
20.5%
NC_014098.1:
Lanthipeptides: allorf_2904135_2904323_lanthipeptide
8
P A A G S G R A Y G P L R R P S P F
25
P G S G A G R P F
14
P T G G S G E A A G D C G R S E P F
31
18.6%
NZ_ML123085.1 and 3 others:
NZ_ML123085.1 Lanthipeptides: allorf_0381774_0381971_lanthipeptide NZ_RDBM01000037.1 Lanthipeptides: allorf_1275501_1275698_lanthipeptide NZ_RDBM01000037.1 Lanthipeptides: allorf_1275501_1275698_lanthipeptide
Lanthipeptides: allorf_0381774_0381971_lanthipeptide
20
R R P S P F P E A R
29
R R P S P E A R
34
R R P S P G Q E A R
43
18.2%
NC_021177.1 and 6 others:
NZ_BMUG01000001.1 Lanthipeptides: allorf_0358025_0358183_lanthipeptide NZ_BMUG01000001.1 Lanthipeptides: allorf_0358025_0358183_lanthipeptide NZ_CP054926.1 Lanthipeptides: allorf_2551449_2551640_lanthipeptide NZ_CP071044.1 Lanthipeptides: allorf_2560866_2561024_lanthipeptide NZ_JOJC01000008.1 Lanthipeptides: allorf_032194_032352_lanthipeptide NZ_JOJC01000008.1 Lanthipeptides: allorf_032194_032352_lanthipeptide
Lanthipeptides: allorf_2607385_2607543_lanthipeptide
21
R P S P F P E A R
29
R P S P P E A R
36
R P S P L P E A R
44
15.2%
NZ_CP098485.1:
Lanthipeptides: allorf_6386562_6386786_lanthipeptide
7
G P A A G S G R A Y-G P L R R P S P F
25
G P A G G A Y G +R R +
18
G P A G G C G E A Y R G T I R R N R T Y
37

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 22.32 out of 27.04
Confidence: medium
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 19.52 out of 19.52
Confidence: strong
Additional weak hits (9):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 12.81 out of 26.06
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 15.85 out of 29.38
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 12.48 out of 28.14
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 18.09 out of 31.73
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.28 out of 30.25
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 14.70 out of 21.55
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.10 out of 30.25
Confidence: weak
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.83 out of 20.97
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.80 out of 28.19
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

MQC87_RS27525 - Class II
  Cleavage pHMM score: -4.20
  RODEO score: 0
  Monoisotopic mass: 1831.9 Da
  Molecular weight: 1833.0 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1851.0 Da N = 1
    1869.0 Da N = 2
    1887.0 Da N = 3
    1905.0 Da N = 4
MQC87_RS27530 - Class II
  Cleavage pHMM score: -7.30
  RODEO score: 0
  Monoisotopic mass: 1293.7 Da
  Molecular weight: 1294.5 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1312.5 Da N = 1
allorf_012354_012542 - Class II
  Cleavage pHMM score: -6.90
  RODEO score: 0
  Monoisotopic mass: 5576.0 Da
  Molecular weight: 5579.5 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    5597.5 Da N = 1
    5615.5 Da N = 2
allorf_026695_026847 - Class II
  Cleavage pHMM score: -6.50
  RODEO score: 0
  Monoisotopic mass: 2885.5 Da
  Molecular weight: 2887.2 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2905.3 Da N = 1
MQC87_RS27525 - Class II
  Cleavage pHMM score: -4.20
  RODEO score: 0
  Monoisotopic mass: 1831.9 Da
  Molecular weight: 1833.0 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1851.0 Da N = 1
    1869.0 Da N = 2
    1887.0 Da N = 3
    1905.0 Da N = 4
MQC87_RS27530 - Class II
  Cleavage pHMM score: -7.30
  RODEO score: 0
  Monoisotopic mass: 1293.7 Da
  Molecular weight: 1294.5 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1312.5 Da N = 1
allorf_026695_026847 - Class II
  Cleavage pHMM score: -6.50
  RODEO score: 0
  Monoisotopic mass: 2885.5 Da
  Molecular weight: 2887.2 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2905.3 Da N = 1
MQC87_RS27525 - Class II
  Cleavage pHMM score: -4.20
  RODEO score: 0
  Monoisotopic mass: 1831.9 Da
  Molecular weight: 1833.0 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1851.0 Da N = 1
    1869.0 Da N = 2
    1887.0 Da N = 3
    1905.0 Da N = 4
MQC87_RS27530 - Class II
  Cleavage pHMM score: -7.30
  RODEO score: 0
  Monoisotopic mass: 1293.7 Da
  Molecular weight: 1294.5 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1312.5 Da N = 1
allorf_026695_026847 - Class II
  Cleavage pHMM score: -6.50
  RODEO score: 0
  Monoisotopic mass: 2885.5 Da
  Molecular weight: 2887.2 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2905.3 Da N = 1
MQC87_RS27525 - Class II
  Cleavage pHMM score: -4.20
  RODEO score: 0
  Monoisotopic mass: 1831.9 Da
  Molecular weight: 1833.0 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1851.0 Da N = 1
    1869.0 Da N = 2
    1887.0 Da N = 3
    1905.0 Da N = 4
MQC87_RS27530 - Class II
  Cleavage pHMM score: -7.30
  RODEO score: 0
  Monoisotopic mass: 1293.7 Da
  Molecular weight: 1294.5 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1312.5 Da N = 1
allorf_026695_026847 - Class II
  Cleavage pHMM score: -6.50
  RODEO score: 0
  Monoisotopic mass: 2885.5 Da
  Molecular weight: 2887.2 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2905.3 Da N = 1

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsQ1 | Two-component system AfsQ1-Q2, activator of antibiotic production
DasR | N-acetylglucosamine dependent repressor

NZ_JALDPQ010000065.1 - Region 2 - NI-siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 85,276 - 115,054 nt. (total: 29,779 nt) Show pHMM detection rules used
NI-siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxygenase
MQC87_RS27765: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

MQC87_RS27805: lysine/ornithine N-monooxygenase

smcogs
  SMCOG1080: lysine/ornithine N-monooxygenase

Hydrolases: hydrolase
MQC87_RS27830: asparagine synthase (glutamine-hydrolyzing)

smcogs
  SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Lyases: decarboxylase
MQC87_RS27800: Decarboxylase, pyridoxal-dependent

smcogs
  SMCOG1180: Decarboxylase, pyridoxal-dependent

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NI-siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000941.3 |  | 0.88 | other (other) | desferrioxamin B | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001478.5 |  | 0.83 | other (other) | desferrioxamine E | Streptomyces sp. ID38640
BGC0002305.2 |  | 0.78 | other (other) | legonoxamine A, desferrioxamine B, legonoxamine B | Streptomyces sp.
BGC0000940.5 |  | 0.71 | other (other) | desferrioxamin B, desferrioxamine E | Streptomyces coelicolor A3(2)
BGC0001453.5 |  | 0.71 | other (other) | desferrioxamine | Streptomyces argillaceus
BGC0001572.3 |  | 0.70 | other (other) | desferrioxamine E | Pantoea agglomerans
BGC0002464.3 |  | 0.62 | other (other) | alcaligin | Bordetella pertussis Tohama I
BGC0002690.2 |  | 0.59 | other (other) | FW0622 | Verrucosispora sp. FIM060022
BGC0002620.2 |  | 0.55 | other (other) | fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4 | Fulvivirga marina
BGC0002469.2 |  | 0.54 | other (other) | woodybactin A, woodybactin B, woodybactin C, woodybactin D | Shewanella woodyi ATCC 51908

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000941.3 |  | 0.88 | other (other) | desferrioxamin B | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001478.5 |  | 0.83 | other (other) | desferrioxamine E | Streptomyces sp. ID38640
BGC0002305.2 |  | 0.78 | other (other) | legonoxamine A, desferrioxamine B, legonoxamine B | Streptomyces sp.
BGC0000940.5 |  | 0.71 | other (other) | desferrioxamin B, desferrioxamine E | Streptomyces coelicolor A3(2)
BGC0001453.5 |  | 0.71 | other (other) | desferrioxamine | Streptomyces argillaceus
BGC0001572.3 |  | 0.70 | other (other) | desferrioxamine E | Pantoea agglomerans
BGC0002464.3 |  | 0.62 | other (other) | alcaligin | Bordetella pertussis Tohama I
BGC0002690.2 |  | 0.59 | other (other) | FW0622 | Verrucosispora sp. FIM060022
BGC0002620.2 |  | 0.55 | other (other) | fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4 | Fulvivirga marina
BGC0002469.2 |  | 0.54 | other (other) | woodybactin A, woodybactin B, woodybactin C, woodybactin D | Shewanella woodyi ATCC 51908

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.52 out of 19.26
Confidence: medium
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 36.53 out of 36.53
Confidence: strong
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 27.77 out of 36.53
Confidence: medium
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 28.15 out of 30.11
Confidence: strong
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 28.15 out of 30.11
Confidence: strong
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 18.36 out of 25.31
Confidence: medium
Additional weak hits (11):
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 15.52 out of 20.97
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.65 out of 28.19
Confidence: weak
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.86 out of 19.52
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 18.25 out of 36.54
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 18.29 out of 36.54
Confidence: weak
BldD
Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.62 out of 23.43
Confidence: weak
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.84 out of 26.85
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.28 out of 30.25
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 21.83 out of 30.11
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 30.11
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 22.58 out of 30.11
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
CatR | H2O2-responsive repressor
CelR | Cellobiose uptake repressor
DmdR1 | Iron(II)-dependent repressor

NZ_JALDPQ010000066.1 - Region 1 - RRE-containing,azole-containing-RiPP
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 151,935 - 186,770 nt. (total: 34,836 nt) Show pHMM detection rules used
azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Azole RiPPs
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: hydrolase
MQC87_RS31100: amidohydrolase

smcogs
  SMCOG1244: amidohydrolase

Lyases: dehydratase
MQC87_RS31135: Lantibiotic dehydratase domain protein

smcogs
  SMCOG1155: Lantibiotic dehydratase domain protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | azole-containing-RiPP | RRE-containing | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001146.5 |  |  | 0.37 | ribosomal | cyclothiazomycin C | Streptomyces sp. NRRL WC-3908
BGC0000603.5 |  |  | 0.36 | ribosomal | cyclothiazomycin | Streptomyces hygroscopicus
BGC0001145.5 |  |  | 0.34 | ribosomal | cyclothiazomycin b1 | Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0001472.5 |  |  | 0.33 | ribosomal | berninamycin A | Streptomyces bernensis
BGC0001640.3 |  |  | 0.33 | ribosomal | kocurin | Kocuria rosea
BGC0000607.5 |  |  | 0.32 | ribosomal | micrococcin P1 | Macrococcus caseolyticus
BGC0000569.5 |  |  | 0.31 | ribosomal | plantazolicin | Bacillus velezensis FZB42
BGC0002316.2 |  |  | 0.30 | ribosomal | cebulantin | Saccharopolyspora cebuensis
BGC0001860.4 |  |  | 0.30 | ribosomal | thiomuracin | Thermobispora bispora DSM 43833
BGC0000566.5 |  |  | 0.29 | ribosomal | streptolysin S | Streptococcus pyogenes M1 GAS

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000603.5 |  | 0.51 | ribosomal | cyclothiazomycin | Streptomyces hygroscopicus
BGC0001146.5 |  | 0.51 | ribosomal | cyclothiazomycin C | Streptomyces sp. NRRL WC-3908
BGC0001860.4 |  | 0.50 | ribosomal | thiomuracin | Thermobispora bispora DSM 43833
BGC0001145.5 |  | 0.49 | ribosomal | cyclothiazomycin b1 | Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0001640.3 |  | 0.49 | ribosomal | kocurin | Kocuria rosea
BGC0001472.5 |  | 0.48 | ribosomal | berninamycin A | Streptomyces bernensis
BGC0000607.5 |  | 0.47 | ribosomal | micrococcin P1 | Macrococcus caseolyticus
BGC0001174.4 |  | 0.47 | ribosomal | corynazolicin | Corynebacterium urealyticum DSM 7111
BGC0000569.5 |  | 0.47 | ribosomal | plantazolicin | Bacillus velezensis FZB42
BGC0000613.5 |  | 0.47 | ribosomal | thiomuracin A | Nonomuraea sp. Bp3714-39

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.68 out of 20.47
Confidence: medium
Additional weak hits (2):
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.07 out of 39.62
Confidence: weak
CsoR
Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 21.53 out of 32.38
Confidence: weak
(Thi)azol(in)e containing peptide predictions
Lists the possible core peptides for each biosynthetic enzyme. Predicted tail sequences are also shown, if present.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.
No core peptides found.
RREFinder
TFBS Finder
Azole RiPPs
RRE predictions
RREfinder results sidepanel.

azole-containing-RiPP protocluster (151934...184525)
MQC87_RS31150
  RRE type: Thiopeptide_F_RRE
  Location: 39 - 118
  Score: 62.9
  RRE type: Heterocycloanthracin_C_RRE
  Location: 39 - 125
  Score: 41.8
RRE-containing protocluster (164514...186770)
MQC87_RS31150
  RRE type: Thiopeptide_F_RRE
  Location: 39 - 118
  Score: 62.9
  RRE type: Heterocycloanthracin_C_RRE
  Location: 39 - 125
  Score: 41.8

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
VqsM | Regulator of quorum-sensing signalling systems

Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its possible molecular weights and the scores for cleavage site prediction and RODEO. If relevant, other features, such as macrocycle and amidation, will also be listed.
No core peptides found.
NZ_JALDPQ010000067.1 - Region 1 - NI-siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 57,147 - 89,906 nt. (total: 32,760 nt) Show pHMM detection rules used
NI-siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxygenase
MQC87_RS32915: Antibiotic biosynthesis monooxygenase

smcogs
  SMCOG1258: Antibiotic biosynthesis monooxygenase

Transferases: aminotransferase
MQC87_RS32870: aminotransferase class-III

smcogs
  SMCOG1013: aminotransferase class-III

Isomerases: mutase
MQC87_RS32920: phosphoglycerate mutase

smcogs
  SMCOG1101: phosphoglycerate mutase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NI-siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002692.2 |  | 0.55 | other (other) | speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B | Kribbella speibonae
BGC0000942.4 |  | 0.55 | other (other) | petrobactin | Bacillus anthracis str. Ames
BGC0001713.5 |  | 0.52 | other (other) | ochrobactin | Ochrobactrum anthropi
BGC0002683.2 |  | 0.51 | NRPS | schizokinen | Nostoc sp. PCC 7120 = FACHB-418
BGC0000295.5 |  | 0.51 | NRPS | acinetoferrin | Acinetobacter haemolyticus
BGC0002469.2 |  | 0.51 | other (other) | woodybactin A, woodybactin B, woodybactin C, woodybactin D | Shewanella woodyi ATCC 51908
BGC0001531.5 |  | 0.50 | other (other) | bisucaberin B | Tenacibaculum mesophilum
BGC0000939.5 |  | 0.50 | other (other) | aerobactin | Grimontia hollisae
BGC0001572.3 |  | 0.50 | other (other) | desferrioxamine E | Pantoea agglomerans
BGC0002470.2 |  | 0.49 | other (other) | synechobactin C9, synechobactin C11, synechobactin 13, synechobactin 14, synechobactin 16, synechobactin A, synechobactin B, synechobactin C | Synechococcus sp. PCC 7002

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002692.2 |  | 0.55 | other (other) | speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B | Kribbella speibonae
BGC0000942.4 |  | 0.55 | other (other) | petrobactin | Bacillus anthracis str. Ames
BGC0001713.5 |  | 0.52 | other (other) | ochrobactin | Ochrobactrum anthropi
BGC0002683.2 |  | 0.51 | NRPS | schizokinen | Nostoc sp. PCC 7120 = FACHB-418
BGC0000295.5 |  | 0.51 | NRPS | acinetoferrin | Acinetobacter haemolyticus
BGC0002469.2 |  | 0.51 | other (other) | woodybactin A, woodybactin B, woodybactin C, woodybactin D | Shewanella woodyi ATCC 51908
BGC0001531.5 |  | 0.50 | other (other) | bisucaberin B | Tenacibaculum mesophilum
BGC0000939.5 |  | 0.50 | other (other) | aerobactin | Grimontia hollisae
BGC0001572.3 |  | 0.50 | other (other) | desferrioxamine E | Pantoea agglomerans
BGC0002470.2 |  | 0.49 | other (other) | synechobactin C9, synechobactin C11, synechobactin 13, synechobactin 14, synechobactin 16, synechobactin A, synechobactin B, synechobactin C | Synechococcus sp. PCC 7002

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.26 out of 19.26
Confidence: medium
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 25.36 out of 30.22
Confidence: medium
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 21.90 out of 27.04
Confidence: medium
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 25.84 out of 30.12
Confidence: medium
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.92 out of 20.47
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.93 out of 24.78
Confidence: medium
NrdR
Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 24.17 out of 27.18
Confidence: medium
NrdR
Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 22.03 out of 27.18
Confidence: medium
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.18 out of 20.47
Confidence: medium
Additional weak hits (14):
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 18.19 out of 31.73
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.66 out of 27.78
Confidence: weak
DosR
Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 23.40 out of 29.51
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.39 out of 30.25
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 18.25 out of 30.25
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.04 out of 29.65
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.62 out of 29.65
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.88 out of 29.65
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 23.09 out of 29.65
Confidence: weak
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 19.77 out of 25.88
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.65 out of 28.19
Confidence: weak
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.59 out of 22.40
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.79 out of 29.65
Confidence: weak
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 17.88 out of 24.78
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
ClgR | Caseinolytic protease gene regulator
DasR | N-acetylglucosamine dependent repressor
LexA variant 2 | Repressor of DNA damage response
NrdR | Represses ribonucleotide reductase encoding genes
OsdR | Development and stress management regulator
VqsM | Regulator of quorum-sensing signalling systems

NZ_JALDPQ010000067.1 - Region 2 - hydrogen-cyanide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 193,816 - 206,725 nt. (total: 12,910 nt) Show pHMM detection rules used
hydrogen-cyanide: (Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD) and DAO)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase reductase
MQC87_RS33420: FAD dependent oxidoreductase

smcogs
  SMCOG1103: FAD dependent oxidoreductase

MQC87_RS33430: alkyl hydroperoxide reductase subunit

smcogs
  SMCOG1176: alkyl hydroperoxide reductase subunit

Hydrolases: deaminase
MQC87_RS33450: ornithine cyclodeaminase

smcogs
  SMCOG1158: ornithine cyclodeaminase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | hydrogen-cyanide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002345.2 |  | 0.54 | other (other) | hydrogen cyanide | Pseudomonas fluorescens
BGC0002285.2 |  | 0.29 | ribosomal | aborycin | Streptomyces sp. ZS0098
BGC0000595.3 |  | 0.25 | ribosomal | SCO-2138 | Streptomyces coelicolor A3(2)
BGC0000135.5 |  | 0.21 | PKS | reveromycin A | Streptomyces sp. SN-593

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002345.2 |  | 0.54 | other (other) | hydrogen cyanide | Pseudomonas fluorescens
BGC0002285.2 |  | 0.29 | ribosomal | aborycin | Streptomyces sp. ZS0098
BGC0000595.3 |  | 0.25 | ribosomal | SCO-2138 | Streptomyces coelicolor A3(2)
BGC0000135.5 |  | 0.21 | PKS | reveromycin A | Streptomyces sp. SN-593

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 22.40 out of 22.40
Confidence: strong
Additional weak hits (6):
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.87 out of 20.01
Confidence: weak
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.13 out of 25.75
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.93 out of 39.62
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.49 out of 29.65
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 16.35 out of 33.14
Confidence: weak
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 20.42 out of 22.40
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
HypR | L-hydroxyproline utilization repressor

NZ_JALDPQ010000067.1 - Region 3 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 338,337 - 349,728 nt. (total: 11,392 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002387.2 |  | 0.27 | PKS | yangpumicin A | Micromonospora yangpuensis
BGC0002788.2 |  | 0.25 | PKS | 14-hydroxyisochainin | Streptomyces peucetius subsp. caesius ATCC 27952
BGC0001377.5 |  | 0.24 | PKS | uncialamycin | Streptomyces uncialis
BGC0001060.5 |  | 0.22 | PKS | dynemicin A | Micromonospora chersina
BGC0001984.3 |  | 0.20 | NRPS | sarpeptin A, sarpeptin B | Streptomyces sp.
BGC0000241.5 |  | 0.19 | PKS, saccharide | lomaiviticin A, lomaiviticin C, lomaiviticin D, lomaiviticin E | Salinispora tropica CNB-440
BGC0001693.3 |  | 0.18 | PKS | nenestatin | Micromonospora echinospora

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002387.2 |  | 0.27 | PKS | yangpumicin A | Micromonospora yangpuensis
BGC0002788.2 |  | 0.25 | PKS | 14-hydroxyisochainin | Streptomyces peucetius subsp. caesius ATCC 27952
BGC0001377.5 |  | 0.24 | PKS | uncialamycin | Streptomyces uncialis
BGC0001060.5 |  | 0.22 | PKS | dynemicin A | Micromonospora chersina
BGC0001984.3 |  | 0.20 | NRPS | sarpeptin A, sarpeptin B | Streptomyces sp.
BGC0000241.5 |  | 0.19 | PKS, saccharide | lomaiviticin A, lomaiviticin C, lomaiviticin D, lomaiviticin E | Salinispora tropica CNB-440
BGC0001693.3 |  | 0.18 | PKS | nenestatin | Micromonospora echinospora

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.80 out of 20.47
Confidence: medium
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.22 out of 26.85
Confidence: medium
Additional weak hits (2):
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.40 out of 29.65
Confidence: weak
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 19.18 out of 27.04
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
RutR | Regulator of the pyrimidine and purine metabolism
VqsM | Regulator of quorum-sensing signalling systems

NZ_JALDPQ010000067.1 - Region 4 - ectoine
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 748,613 - 758,987 nt. (total: 10,375 nt) Show pHMM detection rules used
ectoine: ectoine_synt

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
MQC87_RS35870: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

Ligases: ligase
MQC87_RS35845: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ectoine | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000342.4 |  | 0.59 | NRPS | enniatin | Fusarium equiseti
BGC0000307.4 |  | 0.59 | NRPS | AbT1 | Aureobasidium pullulans
BGC0001641.4 |  | 0.59 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001778.5 |  | 0.48 | other (other) | showdomycin | Streptomyces showdoensis
BGC0002020.3 |  | 0.44 | NRPS, saccharide | photolose, oligosaccharide 1 (GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 2 (GlcNAc-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 3 (GlcNAc-β(1-4)-GlcNAc-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 4 (GlcN-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 5 (6-phosphoGlcN-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc) | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000131.5 |  | 0.43 | PKS | pyrrolomycin | Streptomyces sp. UC 11065
BGC0002097.3 |  | 0.41 | NRPS, PKS, saccharide | kosinostatin | Micromonospora sp. 28ISP2-46
BGC0001073.5 |  | 0.40 | NRPS, PKS | kosinostatin | Micromonospora sp. TP-A0468
BGC0002555.3 |  | 0.40 | NRPS, PKS | emerimicin V, emerimicin VI, emerimicin VII, emerimicin VIII, emerimicin IX, emerimicin X | Acremonium sp.
BGC0000312.4 |  | 0.40 | NRPS | bassianolide | Beauveria bassiana

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000342.4 |  | 0.59 | NRPS | enniatin | Fusarium equiseti
BGC0000307.4 |  | 0.59 | NRPS | AbT1 | Aureobasidium pullulans
BGC0001641.4 |  | 0.59 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001778.5 |  | 0.48 | other (other) | showdomycin | Streptomyces showdoensis
BGC0002020.3 |  | 0.44 | NRPS, saccharide | photolose, oligosaccharide 1 (GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 2 (GlcNAc-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 3 (GlcNAc-β(1-4)-GlcNAc-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 4 (GlcN-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc), oligosaccharide 5 (6-phosphoGlcN-β(1-4)-GlcNAc-β(1-4)-1,6-anhydro-β-GlcNAc) | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000131.5 |  | 0.43 | PKS | pyrrolomycin | Streptomyces sp. UC 11065
BGC0002097.3 |  | 0.41 | NRPS, PKS, saccharide | kosinostatin | Micromonospora sp. 28ISP2-46
BGC0001073.5 |  | 0.40 | NRPS, PKS | kosinostatin | Micromonospora sp. TP-A0468
BGC0002555.3 |  | 0.40 | NRPS, PKS | emerimicin V, emerimicin VI, emerimicin VII, emerimicin VIII, emerimicin IX, emerimicin X | Acremonium sp.
BGC0000312.4 |  | 0.40 | NRPS | bassianolide | Beauveria bassiana

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 26.07 out of 30.12
Confidence: medium
Additional weak hits (3):
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.42 out of 29.65
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.27 out of 32.93
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 19.59 out of 29.65
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
OsdR | Development and stress management regulator

NZ_JALDPQ010000068.1 - Region 1 - NRPS,NRPS-like,PKS-like,betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 120,783 - 189,630 nt. (total: 68,848 nt) Show pHMM detection rules used
PKS-like: (t2pks2 or ksIII)
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
betalactone: (HMGL-like and AMP-binding)
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxygenase
MQC87_RS36685: dioxygenase, TauD/TfdA

smcogs
  SMCOG1121: dioxygenase, TauD/TfdA

MQC87_RS36770: cytochrome P450

smcogs
  SMCOG1007: cytochrome P450

MQC87_RS36790: cytochrome P450

smcogs
  SMCOG1007: cytochrome P450

Transferases: PPTase
MQC87_RS36815: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1060: 4'-phosphopantetheinyl transferase

Hydrolases: esterase
MQC87_RS36765: thioesterase

smcogs
  SMCOG1004: thioesterase

MQC87_RS36780: thioesterase

smcogs
  SMCOG1004: thioesterase

MQC87_RS36800: thioesterase

smcogs
  SMCOG1004: thioesterase

Ligases: ligase synthase
MQC87_RS36635: carbamoyl phosphate synthase small subunit

smcogs
  SMCOG1249: carbamoyl phosphate synthase small subunit

MQC87_RS36680: 8-amino-7-oxononanoate synthase

smcogs
  SMCOG1109: 8-amino-7-oxononanoate synthase

MQC87_RS36690: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs
  SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

MQC87_RS36745: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

MQC87_RS36775: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

MQC87_RS36805: 2-isopropylmalate synthase

smcogs
  SMCOG1271: 2-isopropylmalate synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | PKS-like | NRPS | betalactone | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | --- | ---
BGC0000342.4 |  |  |  |  | 1.06 | NRPS | enniatin | Fusarium equiseti
BGC0001132.4 |  |  |  |  | 1.05 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.4 |  |  |  |  | 1.04 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  |  |  |  | 1.04 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  |  |  |  | 1.02 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001641.4 |  |  |  |  | 1.00 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002164.2 |  |  |  |  | 1.00 | NRPS | peramine | Epichloe festucae
BGC0000307.4 |  |  |  |  | 0.98 | NRPS | AbT1 | Aureobasidium pullulans
BGC0001758.4 |  |  |  |  | 0.96 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0002075.3 |  |  |  |  | 0.95 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000342.4 |  | 0.68 | NRPS | enniatin | Fusarium equiseti
BGC0001132.4 |  | 0.68 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.4 |  | 0.68 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.68 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  | 0.67 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001641.4 |  | 0.67 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002164.2 |  | 0.67 | NRPS | peramine | Epichloe festucae
BGC0000307.4 |  | 0.66 | NRPS | AbT1 | Aureobasidium pullulans
BGC0001758.4 |  | 0.65 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0002075.3 |  | 0.65 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.98 out of 23.79
Confidence: medium
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.09 out of 20.47
Confidence: medium
Additional weak hits (12):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.66 out of 29.38
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.41 out of 30.25
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.29 out of 28.14
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 19.59 out of 33.73
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.07 out of 27.78
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 14.17 out of 26.06
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.25 out of 28.14
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 17.99 out of 29.38
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.34 out of 28.19
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 16.95 out of 28.19
Confidence: weak
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 19.56 out of 27.04
Confidence: weak
BldD
Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.10 out of 23.43
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 120782 - 189630:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X) + (Gly - NMe-X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 120782 - 161751:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Gly - NMe-X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 135082 - 189630:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X) + (Gly - NMe-X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
MQC87_RS36700: X
AMP-binding (359..526): X
No predictions made
MQC87_RS36745: Gly - X
Search NORINE for peptide: strict or relaxed
AMP-binding (24..428): Gly
nrpys: Gly

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    gly (Gly)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FCLTFDIAALELQGLCGGEWNLYGPTETTIWSLL
  Nearest Stachelhaus code(s):
    Gly DILQLGLIWK (88% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1093..1500): X
nrpys: Phe, Trp, Ph-Gly, Tyr, bOH-Tyr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LSYSFDPTFCECTFMVAGEINAYGPTEATVDTLY
  Nearest Stachelhaus code(s):
    bOH-Tyr DASTIAAVDK (56% 8Å match)
  Stachelhaus code match:
    70% (weak)

MQC87_RS36775: X
AMP-binding (18..416): X
nrpys: (unknown)

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Unpolar aromatic ring (Phe, Trp)
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    FNPAFDTFHWESLSQTGGDVNLYGPTEGTTAATA
  Nearest Stachelhaus code(s):
    Leu DAWLAGLTAK (74% 8Å match)
  Stachelhaus code match:
    80% (moderate)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
IolR | Regulator of the inositol catabolism
VqsM | Regulator of quorum-sensing signalling systems