GCF_022557275.1 - 4 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP092907.1 (Enterococcus faecalis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	arylpolyene,NRPS	333,051	377,347
Region 1.2	terpene-precursor	724,697	745,578
Region 1.3	lanthipeptide-class-ii	814,386	842,233	Low	staphylococcin C55 α/staphylococcin C55 β	ribosomal:RiPP:Lanthipeptide
Region 1.4	cyclic-lactone-autoinducer	1,566,535	1,587,263

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	arylpolyene,NRPS	333,051	377,347
Region 1.2	terpene-precursor	724,697	745,578
Region 1.3	lanthipeptide-class-ii	814,386	842,233	Low	staphylococcin C55 α/staphylococcin C55 β	ribosomal:RiPP:Lanthipeptide
Region 1.4	cyclic-lactone-autoinducer	1,566,535	1,587,263

No secondary metabolite regions were found in these records:: NZ_CP092908.1 (Enterococcus faecalis); NZ_CP092909.1 (Enterococcus faecalis); NZ_CP092910.1 (Enterococcus faecalis)

Compact view

NZ_CP092907.1 - Region 1 - NRPS,arylpolyene

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Location: 333,051 - 377,347 nt. (total: 44,297 nt) Show pHMM detection rules used

arylpolyene: (APE_KS1 or APE_KS2)
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

MK744_RS01785: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

MK744_RS01840: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

Transferases: PPTase transferase

MK744_RS01740: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

MK744_RS01815: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

MK744_RS01820: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

Lyases: decarboxylase

MK744_RS01865: Decarboxylase, pyridoxal-dependent

smcogs: SMCOG1180: Decarboxylase, pyridoxal-dependent

Ligases: ligase synthase

MK744_RS01805: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

MK744_RS01810: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Translocases: permease

MK744_RS01870: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001261.3	0.58	NRPS	AM-toxin	Alternaria alternata
BGC0001166.5	0.57	NRPS	HC-toxin	Alternaria jesenskae
BGC0002286.3	0.54	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002008.3	0.38	other (other)	aryl polyenes	Xenorhabdus doucetiae
BGC0000836.5	0.38	other (other)	APE Ec	Escherichia coli CFT073
BGC0000837.4	0.37	other (other)	APE Vf	Aliivibrio fischeri ES114
BGC0000888.5	0.34	other (other)	bacilysin	Bacillus sp. CS93
BGC0001928.2	0.33	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0002518.3	0.32	NRPS	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0002547.2	0.32	PKS	youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4	Streptomyces youssoufiensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001261.3	0.63	NRPS	AM-toxin	Alternaria alternata
BGC0001166.5	0.62	NRPS	HC-toxin	Alternaria jesenskae
BGC0002286.3	0.61	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002008.3	0.51	other (other)	aryl polyenes	Xenorhabdus doucetiae
BGC0000836.5	0.51	other (other)	APE Ec	Escherichia coli CFT073
BGC0000837.4	0.50	other (other)	APE Vf	Aliivibrio fischeri ES114
BGC0000888.5	0.49	other (other)	bacilysin	Bacillus sp. CS93
BGC0001928.2	0.48	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0002518.3	0.47	NRPS	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0002547.2	0.47	PKS	youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4	Streptomyces youssoufiensis

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.27 out of 26.06

Confidence: strong

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.55 out of 18.46

Confidence: strong

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.93 out of 30.25

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.54 out of 26.06

Confidence: medium

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 29.42 out of 32.74

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.37 out of 29.38

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.31 out of 30.25

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.99 out of 30.25

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.28 out of 27.78

Confidence: strong

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 21.07 out of 25.31

Confidence: medium

Additional weak hits (3):

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 23.10 out of 36.53

Confidence: weak

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 19.58 out of 27.18

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 23.73 out of 29.65

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 333050 - 377347:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

MK744_RS01810: X

AMP-binding (15..416): X

nrpys: Gly, Ala, Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LGMAFDPSIAQFDIISCGEFNFYGPSECSVYSTV
Nearest Stachelhaus code(s):: Cap DPQDIGIVNK (50% 8Å match)
Stachelhaus code match:: 60% (weak)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CatR	H2O2-responsive repressor
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
FuR variant 1	Ferric Uptake Regulator
FuR variant 2	Ferric Uptake Regulator
MogR	Repressor of flagellar motility genes
RpoN	Regulator of nitrogen assimilation and virulence

NZ_CP092907.1 - Region 2 - terpene-precursor

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Location: 724,697 - 745,578 nt. (total: 20,882 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: peptidase

MK744_RS03515: methionine aminopeptidase

smcogs: SMCOG1172: methionine aminopeptidase

Ligases: synthetase

MK744_RS03550: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002309.2	0.36	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000639.3	0.34	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.34	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0001605.3	0.32	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001075.5	0.31	PKS, terpene	aurachin RE	Rhodococcus erythropolis
BGC0001456.3	0.30	terpene	isorenieratene	Streptomyces argillaceus
BGC0000286.3	0.30	PKS	viguiepinol	Streptomyces sp. KO-3988

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002309.2	0.36	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000639.3	0.34	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.34	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0001605.3	0.32	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001075.5	0.31	PKS, terpene	aurachin RE	Rhodococcus erythropolis
BGC0001456.3	0.30	terpene	isorenieratene	Streptomyces argillaceus
BGC0000286.3	0.30	PKS	viguiepinol	Streptomyces sp. KO-3988

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

MK744_RS03550: PT_FPPS_like

Domain 1 (29 - 276): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: IPP, DMAPP → FPP

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.25 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.38 out of 27.78

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.87 out of 28.19

Confidence: medium

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ZuR variant 1	Zinc-responsive repressor

NZ_CP092907.1 - Region 3 - lanthipeptide-class-ii

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Location: 814,386 - 842,233 nt. (total: 27,848 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

MK744_RS04010: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Lyases: cyclase

MK744_RS03995: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

MK744_RS04005: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000520.5	0.78	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0000555.3	0.70	ribosomal	staphylococcin C55 α, staphylococcin C55 β	Staphylococcus aureus
BGC0001229.4	0.63	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0002110.3	0.59	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0001391.3	0.55	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000525.5	0.53	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000517.4	0.51	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0001555.4	0.51	ribosomal	colicin V	Escherichia coli chi7122
BGC0001210.5	0.51	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0002663.2	0.51	ribosomal	amyloliquecidin GF610	Bacillus amyloliquefaciens UMAF6639

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000520.5	0.78	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0000555.3	0.70	ribosomal	staphylococcin C55 α, staphylococcin C55 β	Staphylococcus aureus
BGC0001229.4	0.63	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0002110.3	0.59	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0001391.3	0.55	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000525.5	0.53	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000517.4	0.51	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0001555.4	0.51	ribosomal	colicin V	Escherichia coli chi7122
BGC0001210.5	0.51	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0002663.2	0.51	ribosomal	amyloliquecidin GF610	Bacillus amyloliquefaciens UMAF6639

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for MK744_RS03995

MK744_RS03985

Leader:

MRDEENNETLINNEQVAWFEEVADQSFDDDVFGA

Core:

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

Core with dehydrations:

CysDhbDhbNDhbFDhaLDhaDYWGNKGNWCysDhbADhbHECysMGWCysK

antiSMASH-DB 4.0 matches for MK744_RS03985

100.0%

NZ_AP026714.1and 21 others:

NZ_AP026714.1 Lanthipeptides: PO853_RS06515_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11265_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11265_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03985_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03985_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09810_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09810_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00085_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00085_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07700_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07700_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03735_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03735_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00120_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00120_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07750_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07750_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04675_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04675_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07990_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07990_lanthipeptide

Lanthipeptides: PO853_RS06515_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

93.3%

NZ_BLIS01000009.1and 7 others:

NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04820_lanthipeptideNZ_LR134317.1 Lanthipeptides: EL136_RS01685_lanthipeptideNZ_LR134317.1 Lanthipeptides: EL136_RS01685_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02620_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02620_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01935_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01935_lanthipeptide

Lanthipeptides: GVO03_RS04820_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

CTTNTFSLSDYWGNKGNWCT THECM WCK

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

93.3%

NZ_CP061868.1and 1 other:

NZ_CP061868.1 Lanthipeptides: IE339_RS06330_lanthipeptide

Lanthipeptides: IE339_RS06330_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

CTTNTFSLSDYWGNKG WCTATHECM WCK

CTTNTFSLSDYWGNKGGWCTATHECMSWCK

with 105 more sequence matches

Only the first 10 are displayed here.

93.3%

NZ_PCGR01000003.1and 1 other:

NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09620_lanthipeptide

Lanthipeptides: CQS04_RS09620_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

CTTNTFSLSDYWGN GNWCTATHECM WCK

CTTNTFSLSDYWGNNGNWCTATHECMSWCK

86.7%

NZ_FMPI01000012.1and 1 other:

NZ_FMPI01000012.1 Lanthipeptides: BJR39_RS08305_lanthipeptide

Lanthipeptides: BJR39_RS08305_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

C+TNTFSLSDYWGN GNWCTA+HECM WCK

CSTNTFSLSDYWGNNGNWCTASHECMSWCK

86.7%

NZ_NUIO01000031.1and 1 other:

NZ_NUIO01000031.1 Lanthipeptides: CN977_RS23160_lanthipeptide

Lanthipeptides: CN977_RS23160_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

CTTNTFSLSDYWGN G+WCTATHEC+ WCK

CTTNTFSLSDYWGNDGSWCTATHECLSWCK

83.3%

NZ_CACZYW010000004.1and 1 other:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02825_lanthipeptide

Lanthipeptides: HUF10_RS02825_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

C+TNTFSLSDYWGN GNWCT +HECM WCK

CSTNTFSLSDYWGNNGNWCTLSHECMAWCK

83.3%

NZ_CP027862.1and 1 other:

NZ_CP027862.1 Lanthipeptides: allorf_0097945_0098112_lanthipeptide

Lanthipeptides: allorf_0097945_0098112_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

C+TNTFSLSDYWGN+G WCT THECM WCK

CSTNTFSLSDYWGNRGYWCTLTHECMSWCK

83.3%

NZ_CP034414.1and 1 other:

NZ_CP034414.1 Lanthipeptides: EI692_RS18440_lanthipeptide

Lanthipeptides: EI692_RS18440_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

C+TNTFSLSDYWGNKG WCT +HECM WCK

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

83.3%

NZ_QGEE01000020.1and 5 others:

NZ_QGEE01000020.1 Lanthipeptides: DKP74_RS06160_lanthipeptideNZ_QGEF01000018.1 Lanthipeptides: DKP75_RS05595_lanthipeptideNZ_QGEF01000018.1 Lanthipeptides: DKP75_RS05595_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05380_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05380_lanthipeptide

Lanthipeptides: DKP74_RS06160_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

C+TNTFSLSDYWGN+GNWCT +HECM WCK

CSTNTFSLSDYWGNRGNWCTLSHECMAWCK

80.0%

NZ_CP016767.1and 11 others:

NZ_CP016767.1 Lanthipeptides: BCV50_RS13410_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15325_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15325_lanthipeptideNZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07920_lanthipeptideNZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07920_lanthipeptideNZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00580_lanthipeptideNZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00580_lanthipeptideNZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17015_lanthipeptideNZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17015_lanthipeptideNZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04645_lanthipeptideNZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04645_lanthipeptide

Lanthipeptides: BCV50_RS13410_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWC

CTTNTFSLSDYWGNKG WCT + ECM WC

CTTNTFSLSDYWGNKGGWCTVSKECMAWC

80.0%

NZ_CP051884.1and 2 others:

NZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptide

Lanthipeptides: HGK68_RS15125_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

C+TNTFSLSDYWGN G CT THECM WCK

CSTNTFSLSDYWGNNGWLCTITHECMSWCK

80.0%

NZ_FNHR01000005.1and 1 other:

NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05590_lanthipeptide

Lanthipeptides: BLQ37_RS05590_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

C+TNTFSLSDY GN GNWCT +HECM WCK

CSTNTFSLSDYMGNNGNWCTISHECMAWCK

MIBiG 4.0 matches for MK744_RS03985

63.3%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

CTTNTFSLSDYWGNKGNWCTATHECMGWC

CTTNTFSLS+ GN G WCT T EC C

CTTNTFSLSNALGNNGGWCTLTKECQPNC

40.0%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

FSLSDYWGNKGNWCTATHECMGWC

+++S GNKG +CT T ECM C

YNISCRLGNKGAYCTLTVECMPSC

12.8%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

CTATHECMGWC

CT + EC C

CTLSKECQPNC

MK744_RS03990

Leader:

MNNDKQNEPNVDLELGKYLEADLISLTDDEVTGG

Core:

GTPTITIPISIAVSGWISDKTCPTSVCTRAC

Core with dehydrations:

GDhbPDhbIDhbIPIDhaIAVDhaGWIDhaDKDhbCysPDhbDhaVCysDhbRACys

antiSMASH-DB 4.0 matches for MK744_RS03990

100.0%

NZ_AP026714.1and 21 others:

NZ_AP026714.1 Lanthipeptides: PO853_RS06520_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11270_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11270_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03990_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03990_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09815_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09815_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00090_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00090_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07695_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07695_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03740_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03740_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00125_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00125_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07745_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07745_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04680_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04680_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07985_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07985_lanthipeptide

Lanthipeptides: PO853_RS06520_lanthipeptide

GTPTITIPISIAVSGWISDKTCPTSVCTRAC

61.3%

NZ_CP051884.1and 3 others:

NZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptide

Lanthipeptides: HGK68_RS15130_lanthipeptide

GTPTITIPISIAVSGWISDKTCPTSVCTRAC

GTPT+ + I VS WIS+ TCP+S CTRAC

GTPTVVLSI---VSAWISNNTCPSSACTRAC

61.3%

NZ_CP061868.1and 1 other:

NZ_CP061868.1 Lanthipeptides: IE339_RS06335_lanthipeptide

Lanthipeptides: IE339_RS06335_lanthipeptide

TPTITIPISIAVSGWISDKTCPTSVCTRAC

TPTI I AV+G+IS TCPT+ CTRAC

TPTIVI---TAVTGYISTNTCPTTSCTRAC

with 77 more sequence matches

Only the first 10 are displayed here.

61.3%

NZ_NUIO01000031.1and 1 other:

NZ_NUIO01000031.1 Lanthipeptides: CN977_RS23165_lanthipeptide

Lanthipeptides: CN977_RS23165_lanthipeptide

TPTITIPISIAVSGWISDKTCPTSVCTRAC

TPT++I ++ AVSG+IS TCPT+ CTRAC

TPTVSIALT-AVSGYISSNTCPTTACTRAC

54.8%

NZ_CP027862.1and 1 other:

NZ_CP027862.1 Lanthipeptides: C3B71_RS16030_lanthipeptide

Lanthipeptides: C3B71_RS16030_lanthipeptide

TPTITIPISIAVSGWISDKTCPTSVCTRAC

TP + +AV G+IS TCPT+VCTRAC

TPAVATAALLAVGGFISHNTCPTTVCTRAC

54.8%

NZ_CP034414.1and 1 other:

NZ_CP034414.1 Lanthipeptides: EI692_RS18435_lanthipeptide

Lanthipeptides: EI692_RS18435_lanthipeptide

ITIPISIAVSGWISDKTCPTSVCTRAC

+T ISI VSG+IS TCP++ CTRAC

VTPAISILVSGFISTNTCPSTACTRAC

54.8%

NZ_PCGR01000003.1and 1 other:

NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09625_lanthipeptide

Lanthipeptides: CQS04_RS09625_lanthipeptide

GTPTITIPISIAVSGWISDKTCPTSVCTRAC

TPTI I A++G+IS +CPT+ CTRAC

ATPTIVI---TAITGYISANSCPTTACTRAC

50.0%

NZ_CACZYW010000004.1and 3 others:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide

Lanthipeptides: HUF10_RS02820_lanthipeptide

PISIAVSGWISDKTCPTSVCTRAC

P+ +AVS ++SDKTCPT+ CTRAC

PVIVAVSAYVSDKTCPTTACTRAC

48.4%

NZ_KE384533.1and 2 others:

NZ_KE384533.1 Lanthipeptides: K329_RS31315_lanthipeptideNZ_KE384533.1 Lanthipeptides: K329_RS31315_lanthipeptide

Lanthipeptides: K329_RS31315_lanthipeptide

TPTITIPISIAVSGWISDKTCPTSVCTRAC

TPTI I + VS ++S TCPT+ CT C

TPTIVISV---VSAYVSTNTCPTTSCTDEC

42.4%

NZ_LR134317.1and 1 other:

NZ_LR134317.1 Lanthipeptides: EL136_RS01690_lanthipeptide

Lanthipeptides: EL136_RS01690_lanthipeptide

IPISIAVSGWISDKTCPTSVCTRAC

+ S+AV+ +IS TCPT+ CTRAC

VKASVAVTAFISANTCPTTSCTRAC

42.4%

NZ_MIFN01000022.1and 1 other:

NZ_MIFN01000022.1 Lanthipeptides: BHL26_RS15355_lanthipeptide

Lanthipeptides: BHL26_RS15355_lanthipeptide

AVSGWISDKTCPTSVCTRAC

AVSG+IS TCP++ CTRAC

AVSGYISSNTCPSTACTRAC

41.9%

NZ_CP016767.1and 3 others:

NZ_CP016767.1 Lanthipeptides: BCV50_RS13415_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptide

Lanthipeptides: BCV50_RS13415_lanthipeptide

PISIAVSGWISDKTCPTSVCTRAC

P ++G+IS TCPT+ CTRAC

PALSVITGYISSNTCPTTACTRAC

41.9%

NZ_CP050134.2and 3 others:

NZ_EQ973330.1 Lanthipeptides: CORMATOL_RS14310_lanthipeptideNZ_LR134504.1 Lanthipeptides: EL293_RS13085_lanthipeptideNZ_LR134504.1 Lanthipeptides: EL293_RS13085_lanthipeptide

Lanthipeptides: HBA49_RS00775_lanthipeptide

PTITIPISIAVSGWISDKTCPTSVCTRAC

P+ IPISIA+ CPT+ C+R C

PSTLIPISIAL--------CPTTRCSRRC

MIBiG 4.0 matches for MK744_RS03990

24.3%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

IPISIAVSGWISDKTCPTSVCTRAC

+ I V+ +S CPT+ CT C

VAIQAGVAVGVSAAFCPTTKCTSRC

19.4%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

CPTSVCTRAC

CPT+ CT C

CPTTKCTSKC

allorf_0815941_0816015

Leader:

MTGARTSGGA

Core:

CGLIRSNAKNLTRS

Core with dehydrations:

CysGLIRDhaNAKNLDhbRDha

antiSMASH-DB 4.0 matches for allorf_0815941_0816015

100.0%

NC_021362.1and 11 others:

NZ_AP025342.1 Lanthipeptides: allorf_1476567_1476641_lanthipeptideNZ_AP026714.1 Lanthipeptides: allorf_1207193_1207267_lanthipeptideNZ_CP010524.1 Lanthipeptides: allorf_0181624_0181698_lanthipeptideNZ_CP020352.1 Lanthipeptides: allorf_0187351_0187425_lanthipeptideNZ_CP023168.1 Lanthipeptides: allorf_0187408_0187482_lanthipeptideNZ_CP039297.1 Lanthipeptides: allorf_0098046_0098120_lanthipeptideNZ_CP040672.1 Lanthipeptides: allorf_1092980_1093054_lanthipeptideNZ_CP059318.1 Lanthipeptides: allorf_0097981_0098055_lanthipeptideNZ_CP087137.1 Lanthipeptides: allorf_0097877_0097951_lanthipeptideNZ_CP118744.1 Lanthipeptides: allorf_0187316_0187390_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: allorf_1660067_1660141_lanthipeptide

Lanthipeptides: allorf_0181474_0181548_lanthipeptide

CGLIRSNAKNLTRS

78.6%

NZ_CP051884.1:

Lanthipeptides: allorf_3277830_3277904_lanthipeptide

CGLIRSNAKNLTRS

CGLIR NAKNLT++

CGLIRCNAKNLTKA

allorf_0817095_0817172

Leader:

MLVWALPVSLAA

Core:

TQGIEFSFSSCRY

Core with dehydrations:

DhbQGIEFDhaFDhaDhaCysRY

antiSMASH-DB 4.0 matches for allorf_0817095_0817172

100.0%

NZ_AP026714.1and 3 others:

NZ_KZ845958.1 Lanthipeptides: allorf_1543968_1544045_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: allorf_000071_000148_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: allorf_1658910_1658987_lanthipeptide

Lanthipeptides: allorf_1208347_1208424_lanthipeptide

TQGIEFSFSSCRY

allorf_0817463_0817624

Leader:

MGRSHGFGSTTTYSFALFRLAFAAA

Core:

PSLRLNLACNRNSPVHSTKGTPSLINEL

Core with dehydrations:

PDhaLRLNLACysNRNDhaPVHDhaDhbKGDhbPDhaLINEL

antiSMASH-DB 4.0 matches for allorf_0817463_0817624

100.0%

NZ_AP026714.1and 3 others:

NZ_KZ845958.1 Lanthipeptides: allorf_1543516_1543677_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: allorf_000439_000600_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: allorf_1658458_1658619_lanthipeptide

Lanthipeptides: allorf_1208715_1208876_lanthipeptide

PSLRLNLACNRNSPVHSTKGTPSLINEL

25.0%

NZ_CP101397.1:

Lanthipeptides: allorf_6458986_6459099_lanthipeptide

CNRNSPVHSTKGTPSL

C+R +P S G+P L

CDRKAPEWSWMGSPLL

21.4%

NZ_AUBN01000022.1:

Lanthipeptides: allorf_16681_16803_lanthipeptide

ACNRNSPVHSTKGTPSLIN

+C R S +G P L +

SCGRGSGSRGIRGWPRLCS

with 1 more sequence matches

17.9%

NZ_KZ454939.1:

Lanthipeptides: allorf_0215974_0216129_lanthipeptide

NRNSPVHST

N++SPVH++

NQDSPVHTS

allorf_0817521_0817646

Leader:

MHARLSRRDGA

Core:

AAKASLNRANEYVVVDPKPCDLPMSRLKVR

Core with dehydrations:

AAKADhaLNRANEYVVVDPKPCysDLPMDhaRLKVR

antiSMASH-DB 4.0 matches for allorf_0817521_0817646

100.0%

NZ_AP026714.1and 3 others:

NZ_KZ845958.1 Lanthipeptides: allorf_1543494_1543619_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: allorf_000497_000622_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: allorf_1658436_1658561_lanthipeptide

Lanthipeptides: allorf_1208773_1208898_lanthipeptide

AAKASLNRANEYVVVDPKPCDLPMSRLKVR

86.7%

NZ_CP101913.1:

Lanthipeptides: allorf_1817119_1817316_lanthipeptide

AKASLNRANEYVVVDPKPCDLPMSRLKVR

AKASLNRANEY VVDPK CDLPMSR+KVR

AKASLNRANEYAVVDPKLCDLPMSRVKVR

20.0%

NZ_CP064879.1:

Lanthipeptides: allorf_8085548_8085745_lanthipeptide

KPCDLPMSRLKV

PC LP+ L V

SPCSLPLYYLCV

allorf_0817696_0817887

Leader:

MWVAEKFQTNLEIAGS

Core:

LRNSFRASLGIENDGGRALFGLGAHLGLPNSDKLRMPFIYIRESDCE

Core with dehydrations:

LRNDhaFRADhaLGIENDGGRALFGLGAHLGLPNDhaDKLRMPFIYIREDhaDCysE

antiSMASH-DB 4.0 matches for allorf_0817696_0817887

100.0%

NZ_AP026714.1and 3 others:

NZ_KZ845958.1 Lanthipeptides: allorf_1543253_1543444_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: allorf_000672_000863_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: allorf_1658195_1658386_lanthipeptide

Lanthipeptides: allorf_1208948_1209139_lanthipeptide

LRNSFRASLGIENDGGRALFGLGAHLGLPNSDKLRMPFIYIRESDCE

57.4%

NZ_CM000721.1:

Lanthipeptides: allorf_5216374_5216547_lanthipeptide

RNSFRASLGIENDGGRALFGLGAHLGLPNSDKLRMPFIY

RNSFRASL ++ GGRAL GLG +GLPNS KLRMP Y

RNSFRASLKCKSLGGRALIGLGVLIGLPNSVKLRMPMTY

17.0%

NZ_JABWGN010000023.1:

Lanthipeptides: HTZ77_RS41305_lanthipeptide

GGRALFGLGAHLGLPN

GG L LG H G P+

GGSTLTVLGCHSGAPS

with 1 more sequence matches

17.0%

NZ_JABWGO010000017.1:

Lanthipeptides: HT134_RS41585_lanthipeptide

GGRALFGLGAHLGLPN

GG L LG H G P+

GGSTLTVLGCHSGTPS

MIBiG 4.0 matches for allorf_0817696_0817887

12.8%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

RNSFRASLGIENDGGRALF

N+F S + N+GG

TNTFSLSNALGNNGGWCTL

allorf_0819132_0819293

Leader:

MSDGQFDWGGRLLKGNGG

Core:

AQRFPQNGWKSFEECKGRRELDCETYKSSRDESRA

Core with dehydrations:

AQRFPQNGWKDhaFEECysKGRRELDCysEDhbYKDhaDhaRDEDhaRA

antiSMASH-DB 4.0 matches for allorf_0819132_0819293

100.0%

NZ_AP026714.1and 4 others:

NZ_CP101913.1 Lanthipeptides: allorf_1818804_1818965_lanthipeptideNZ_KZ845958.1 Lanthipeptides: allorf_1541847_1542008_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: allorf_002108_002269_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: allorf_1656789_1656950_lanthipeptide

Lanthipeptides: allorf_1210384_1210545_lanthipeptide

AQRFPQNGWKSFEECKGRRELDCETYKSSRDESRA

94.3%

NZ_CM000721.1:

Lanthipeptides: allorf_5214947_5215108_lanthipeptide

AQRFPQNGWKSFEECKGRRELDCETYKSSRDESRA

AQRFPQNGWKSF ECKG RELDCETYKSSRDESRA

AQRFPQNGWKSFVECKGIRELDCETYKSSRDESRA

94.3%

NZ_CP039297.1and 3 others:

NZ_CP040672.1 Lanthipeptides: allorf_1096094_1096255_lanthipeptideNZ_CP059318.1 Lanthipeptides: allorf_0101095_0101256_lanthipeptideNZ_CP087137.1 Lanthipeptides: allorf_0100933_0101094_lanthipeptide

Lanthipeptides: allorf_0101160_0101321_lanthipeptide

AQRFPQNGWKSFEECKGRRELDCETYKSSRDESRA

AQRFPQNGWKSF ECKG RELDCETYKSSRDESRA

AQRFPQNGWKSFAECKGTRELDCETYKSSRDESRA

with 1 more sequence matches

88.6%

NC_015215.1:

Lanthipeptides: allorf_0087347_0087508_lanthipeptide

AQRFPQNGWKSFEECKGRRELDCETYKSSRDESRA

AQRFPQNGWKSF ECKG RELDCE+Y SSRDESRA

AQRFPQNGWKSFAECKGIRELDCESYNSSRDESRA

allorf_0819396_0819626

Leader:

MAPRCRLVASWGCSRSQGLGCSPIKAARELGSERRETVRSLSVAGVGNLRGA

Core:

VLSTRGPGWTYRWCTSCSAKGIAG

Core with dehydrations:

VLDhaDhbRGPGWDhbYRWCysDhbDhaCysDhaAKGIAG

antiSMASH-DB 4.0 matches for allorf_0819396_0819626

100.0%

NZ_AP026714.1and 4 others:

NZ_KZ845958.1 Lanthipeptides: allorf_1541514_1541744_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: allorf_002372_002602_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: allorf_002372_002602_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: allorf_1656456_1656686_lanthipeptide

Lanthipeptides: allorf_1210648_1210878_lanthipeptide

VLSTRGPGWTYRWCTSCSAKGIAG

95.8%

NZ_CM000721.1and 4 others:

NZ_CP039297.1 Lanthipeptides: allorf_0101424_0101654_lanthipeptideNZ_CP040672.1 Lanthipeptides: allorf_1096358_1096588_lanthipeptideNZ_CP059318.1 Lanthipeptides: allorf_0101359_0101589_lanthipeptideNZ_CP087137.1 Lanthipeptides: allorf_0101197_0101427_lanthipeptide

Lanthipeptides: allorf_5214614_5214844_lanthipeptide

VLSTRGPGWTYRWCTSCSAKGIAG

VLSTRGPGWT+RWCTSCSAKGIAG

VLSTRGPGWTHRWCTSCSAKGIAG

47.7%

NZ_CP101913.1:

Lanthipeptides: allorf_1819068_1819298_lanthipeptide

VLSTRGPGWTYRWCTSCSAKGIAG

VLSTRGPGWT+RWCTSCSA+ IAG

VLSTRGPGWTHRWCTSCSARSIAG

with 5 more sequence matches

45.5%

NC_015215.1:

Lanthipeptides: allorf_0087611_0087841_lanthipeptide

STRGPGWTYRWCTSCSAKGIAG

STRGP WTYRWCTSC AKGIAG

STRGPEWTYRWCTSCLAKGIAG

32.1%

NZ_CP025546.1and 5 others:

NZ_CP025546.1 Lanthipeptides: allorf_4260056_4260220_lanthipeptideNZ_SDLM01000003.1 Lanthipeptides: allorf_121827_121991_lanthipeptideNZ_SDLM01000003.1 Lanthipeptides: allorf_121827_121991_lanthipeptideNZ_SDLN01000007.1 Lanthipeptides: allorf_135103_135267_lanthipeptideNZ_SDLN01000007.1 Lanthipeptides: allorf_135103_135267_lanthipeptide

Lanthipeptides: allorf_4260056_4260220_lanthipeptide

STRGPGWTYRWCTSCSAKG

+ RGP W W T CS G

TKRGPTWDPLWATPCSLNG

25.0%

NZ_BMVC01000001.1:

Lanthipeptides: IE282_RS02360_lanthipeptide

LSTRGPGWTYRWCTSCS

L+ G +R CT+C+

LAISGEESCFRTCTTCA

25.0%

NZ_NNBJ01000009.1:

Lanthipeptides: CG740_RS39730_lanthipeptide

GPGWTYRWCTSCS

G G +R CT+C+

GEGTCFRTCTTCA

17.2%

NZ_JANIOB010000033.1:

Lanthipeptides: NQ113_RS28010_lanthipeptide

GPGWTYRWCTS

PG+T R C +

NPGFTNRLCPT

MIBiG 4.0 matches for allorf_0819396_0819626

16.7%

BGC0001155.5 (AGY49587.1):

Thiopeptide: GE2270

WCTSCS

+C SCS

FCCSCS

allorf_0820552_0820677

Leader:

MVAQLVEQRIEAPCVGSSTLSHAIYGG

Core:

IAKWLNATDCKSVP

Core with dehydrations:

IAKWLNADhbDCysKDhaVP

antiSMASH-DB 4.0 matches for allorf_0820552_0820677

100.0%

NZ_AP026714.1and 15 others:

NZ_AP026714.1 Lanthipeptides: allorf_1211804_1211929_lanthipeptideNZ_CP028724.1 Lanthipeptides: allorf_2251561_2251686_lanthipeptideNZ_CP092907.1 Lanthipeptides: allorf_0820552_0820677_lanthipeptideNZ_KB944759.1 Lanthipeptides: allorf_0005263_0005388_lanthipeptideNZ_KZ845892.1 Lanthipeptides: allorf_0004017_0004142_lanthipeptideNZ_KZ845958.1 Lanthipeptides: allorf_1540463_1540588_lanthipeptideNZ_KZ845958.1 Lanthipeptides: allorf_1540463_1540588_lanthipeptideNZ_LR607361.1 Lanthipeptides: allorf_1048534_1048659_lanthipeptideNZ_LR607361.1 Lanthipeptides: allorf_1048534_1048659_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: allorf_347989_348114_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: allorf_347989_348114_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: allorf_003528_003653_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: allorf_003528_003653_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: allorf_1655405_1655530_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: allorf_1655405_1655530_lanthipeptide

Lanthipeptides: allorf_1211804_1211929_lanthipeptide

IAKWLNATDCKSVP

Lanthipeptide(s) for MK744_RS04005

MK744_RS03985

Leader:

MRDEENNETLINNEQVAWFEEVADQSFDDDVFGA

Core:

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

Core with dehydrations:

CysDhbDhbNDhbFDhaLDhaDYWGNKGNWCysDhbADhbHECysMGWCysK

antiSMASH-DB 4.0 matches for MK744_RS03985

100.0%

NZ_AP026714.1and 21 others:

Lanthipeptides: PO853_RS06515_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

93.3%

NZ_BLIS01000009.1and 7 others:

Lanthipeptides: GVO03_RS04820_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

CTTNTFSLSDYWGNKGNWCT THECM WCK

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

93.3%

NZ_CP061868.1and 1 other:

NZ_CP061868.1 Lanthipeptides: IE339_RS06330_lanthipeptide

Lanthipeptides: IE339_RS06330_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

CTTNTFSLSDYWGNKG WCTATHECM WCK

CTTNTFSLSDYWGNKGGWCTATHECMSWCK

with 105 more sequence matches

Only the first 10 are displayed here.

93.3%

NZ_PCGR01000003.1and 1 other:

NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09620_lanthipeptide

Lanthipeptides: CQS04_RS09620_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

CTTNTFSLSDYWGN GNWCTATHECM WCK

CTTNTFSLSDYWGNNGNWCTATHECMSWCK

86.7%

NZ_FMPI01000012.1and 1 other:

NZ_FMPI01000012.1 Lanthipeptides: BJR39_RS08305_lanthipeptide

Lanthipeptides: BJR39_RS08305_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

C+TNTFSLSDYWGN GNWCTA+HECM WCK

CSTNTFSLSDYWGNNGNWCTASHECMSWCK

86.7%

NZ_NUIO01000031.1and 1 other:

NZ_NUIO01000031.1 Lanthipeptides: CN977_RS23160_lanthipeptide

Lanthipeptides: CN977_RS23160_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

CTTNTFSLSDYWGN G+WCTATHEC+ WCK

CTTNTFSLSDYWGNDGSWCTATHECLSWCK

83.3%

NZ_CACZYW010000004.1and 1 other:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02825_lanthipeptide

Lanthipeptides: HUF10_RS02825_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

C+TNTFSLSDYWGN GNWCT +HECM WCK

CSTNTFSLSDYWGNNGNWCTLSHECMAWCK

83.3%

NZ_CP027862.1and 1 other:

NZ_CP027862.1 Lanthipeptides: allorf_0097945_0098112_lanthipeptide

Lanthipeptides: allorf_0097945_0098112_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

C+TNTFSLSDYWGN+G WCT THECM WCK

CSTNTFSLSDYWGNRGYWCTLTHECMSWCK

83.3%

NZ_CP034414.1and 1 other:

NZ_CP034414.1 Lanthipeptides: EI692_RS18440_lanthipeptide

Lanthipeptides: EI692_RS18440_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

C+TNTFSLSDYWGNKG WCT +HECM WCK

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

83.3%

NZ_QGEE01000020.1and 5 others:

Lanthipeptides: DKP74_RS06160_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

C+TNTFSLSDYWGN+GNWCT +HECM WCK

CSTNTFSLSDYWGNRGNWCTLSHECMAWCK

80.0%

NZ_CP016767.1and 11 others:

Lanthipeptides: BCV50_RS13410_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWC

CTTNTFSLSDYWGNKG WCT + ECM WC

CTTNTFSLSDYWGNKGGWCTVSKECMAWC

80.0%

NZ_CP051884.1and 2 others:

NZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptide

Lanthipeptides: HGK68_RS15125_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

C+TNTFSLSDYWGN G CT THECM WCK

CSTNTFSLSDYWGNNGWLCTITHECMSWCK

80.0%

NZ_FNHR01000005.1and 1 other:

NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05590_lanthipeptide

Lanthipeptides: BLQ37_RS05590_lanthipeptide

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

C+TNTFSLSDY GN GNWCT +HECM WCK

CSTNTFSLSDYMGNNGNWCTISHECMAWCK

MIBiG 4.0 matches for MK744_RS03985

63.3%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

CTTNTFSLSDYWGNKGNWCTATHECMGWC

CTTNTFSLS+ GN G WCT T EC C

CTTNTFSLSNALGNNGGWCTLTKECQPNC

40.0%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

FSLSDYWGNKGNWCTATHECMGWC

+++S GNKG +CT T ECM C

YNISCRLGNKGAYCTLTVECMPSC

12.8%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

CTATHECMGWC

CT + EC C

CTLSKECQPNC

MK744_RS03990

Leader:

MNNDKQNEPNVDLELGKYLEADLISLTDDEVTGG

Core:

GTPTITIPISIAVSGWISDKTCPTSVCTRAC

Core with dehydrations:

GDhbPDhbIDhbIPIDhaIAVDhaGWIDhaDKDhbCysPDhbDhaVCysDhbRACys

antiSMASH-DB 4.0 matches for MK744_RS03990

100.0%

NZ_AP026714.1and 21 others:

Lanthipeptides: PO853_RS06520_lanthipeptide

GTPTITIPISIAVSGWISDKTCPTSVCTRAC

61.3%

NZ_CP051884.1and 3 others:

NZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptide

Lanthipeptides: HGK68_RS15130_lanthipeptide

GTPTITIPISIAVSGWISDKTCPTSVCTRAC

GTPT+ + I VS WIS+ TCP+S CTRAC

GTPTVVLSI---VSAWISNNTCPSSACTRAC

61.3%

NZ_CP061868.1and 1 other:

NZ_CP061868.1 Lanthipeptides: IE339_RS06335_lanthipeptide

Lanthipeptides: IE339_RS06335_lanthipeptide

TPTITIPISIAVSGWISDKTCPTSVCTRAC

TPTI I AV+G+IS TCPT+ CTRAC

TPTIVI---TAVTGYISTNTCPTTSCTRAC

with 77 more sequence matches

Only the first 10 are displayed here.

61.3%

NZ_NUIO01000031.1and 1 other:

NZ_NUIO01000031.1 Lanthipeptides: CN977_RS23165_lanthipeptide

Lanthipeptides: CN977_RS23165_lanthipeptide

TPTITIPISIAVSGWISDKTCPTSVCTRAC

TPT++I ++ AVSG+IS TCPT+ CTRAC

TPTVSIALT-AVSGYISSNTCPTTACTRAC

54.8%

NZ_CP027862.1and 1 other:

NZ_CP027862.1 Lanthipeptides: C3B71_RS16030_lanthipeptide

Lanthipeptides: C3B71_RS16030_lanthipeptide

TPTITIPISIAVSGWISDKTCPTSVCTRAC

TP + +AV G+IS TCPT+VCTRAC

TPAVATAALLAVGGFISHNTCPTTVCTRAC

54.8%

NZ_CP034414.1and 1 other:

NZ_CP034414.1 Lanthipeptides: EI692_RS18435_lanthipeptide

Lanthipeptides: EI692_RS18435_lanthipeptide

ITIPISIAVSGWISDKTCPTSVCTRAC

+T ISI VSG+IS TCP++ CTRAC

VTPAISILVSGFISTNTCPSTACTRAC

54.8%

NZ_PCGR01000003.1and 1 other:

NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09625_lanthipeptide

Lanthipeptides: CQS04_RS09625_lanthipeptide

GTPTITIPISIAVSGWISDKTCPTSVCTRAC

TPTI I A++G+IS +CPT+ CTRAC

ATPTIVI---TAITGYISANSCPTTACTRAC

50.0%

NZ_CACZYW010000004.1and 3 others:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide

Lanthipeptides: HUF10_RS02820_lanthipeptide

PISIAVSGWISDKTCPTSVCTRAC

P+ +AVS ++SDKTCPT+ CTRAC

PVIVAVSAYVSDKTCPTTACTRAC

48.4%

NZ_KE384533.1and 2 others:

NZ_KE384533.1 Lanthipeptides: K329_RS31315_lanthipeptideNZ_KE384533.1 Lanthipeptides: K329_RS31315_lanthipeptide

Lanthipeptides: K329_RS31315_lanthipeptide

TPTITIPISIAVSGWISDKTCPTSVCTRAC

TPTI I + VS ++S TCPT+ CT C

TPTIVISV---VSAYVSTNTCPTTSCTDEC

42.4%

NZ_LR134317.1and 1 other:

NZ_LR134317.1 Lanthipeptides: EL136_RS01690_lanthipeptide

Lanthipeptides: EL136_RS01690_lanthipeptide

IPISIAVSGWISDKTCPTSVCTRAC

+ S+AV+ +IS TCPT+ CTRAC

VKASVAVTAFISANTCPTTSCTRAC

42.4%

NZ_MIFN01000022.1and 1 other:

NZ_MIFN01000022.1 Lanthipeptides: BHL26_RS15355_lanthipeptide

Lanthipeptides: BHL26_RS15355_lanthipeptide

AVSGWISDKTCPTSVCTRAC

AVSG+IS TCP++ CTRAC

AVSGYISSNTCPSTACTRAC

41.9%

NZ_CP016767.1and 3 others:

NZ_CP016767.1 Lanthipeptides: BCV50_RS13415_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptide

Lanthipeptides: BCV50_RS13415_lanthipeptide

PISIAVSGWISDKTCPTSVCTRAC

P ++G+IS TCPT+ CTRAC

PALSVITGYISSNTCPTTACTRAC

41.9%

NZ_CP050134.2and 3 others:

NZ_EQ973330.1 Lanthipeptides: CORMATOL_RS14310_lanthipeptideNZ_LR134504.1 Lanthipeptides: EL293_RS13085_lanthipeptideNZ_LR134504.1 Lanthipeptides: EL293_RS13085_lanthipeptide

Lanthipeptides: HBA49_RS00775_lanthipeptide

PTITIPISIAVSGWISDKTCPTSVCTRAC

P+ IPISIA+ CPT+ C+R C

PSTLIPISIAL--------CPTTRCSRRC

MIBiG 4.0 matches for MK744_RS03990

24.3%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

IPISIAVSGWISDKTCPTSVCTRAC

+ I V+ +S CPT+ CT C

VAIQAGVAVGVSAAFCPTTKCTSRC

19.4%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

CPTSVCTRAC

CPT+ CT C

CPTTKCTSKC

allorf_0819396_0819626

Leader:

MAPRCRLVASWGCSRSQGLGCSPIKAARELGSERRETVRSLSVAGVGNLRGA

Core:

VLSTRGPGWTYRWCTSCSAKGIAG

Core with dehydrations:

VLDhaDhbRGPGWDhbYRWCysDhbDhaCysDhaAKGIAG

antiSMASH-DB 4.0 matches for allorf_0819396_0819626

100.0%

NZ_AP026714.1and 4 others:

Lanthipeptides: allorf_1210648_1210878_lanthipeptide

VLSTRGPGWTYRWCTSCSAKGIAG

95.8%

NZ_CM000721.1and 4 others:

Lanthipeptides: allorf_5214614_5214844_lanthipeptide

VLSTRGPGWTYRWCTSCSAKGIAG

VLSTRGPGWT+RWCTSCSAKGIAG

VLSTRGPGWTHRWCTSCSAKGIAG

47.7%

NZ_CP101913.1:

Lanthipeptides: allorf_1819068_1819298_lanthipeptide

VLSTRGPGWTYRWCTSCSAKGIAG

VLSTRGPGWT+RWCTSCSA+ IAG

VLSTRGPGWTHRWCTSCSARSIAG

with 5 more sequence matches

45.5%

NC_015215.1:

Lanthipeptides: allorf_0087611_0087841_lanthipeptide

STRGPGWTYRWCTSCSAKGIAG

STRGP WTYRWCTSC AKGIAG

STRGPEWTYRWCTSCLAKGIAG

32.1%

NZ_CP025546.1and 5 others:

Lanthipeptides: allorf_4260056_4260220_lanthipeptide

STRGPGWTYRWCTSCSAKG

+ RGP W W T CS G

TKRGPTWDPLWATPCSLNG

25.0%

NZ_BMVC01000001.1:

Lanthipeptides: IE282_RS02360_lanthipeptide

LSTRGPGWTYRWCTSCS

L+ G +R CT+C+

LAISGEESCFRTCTTCA

25.0%

NZ_NNBJ01000009.1:

Lanthipeptides: CG740_RS39730_lanthipeptide

GPGWTYRWCTSCS

G G +R CT+C+

GEGTCFRTCTTCA

17.2%

NZ_JANIOB010000033.1:

Lanthipeptides: NQ113_RS28010_lanthipeptide

GPGWTYRWCTS

PG+T R C +

NPGFTNRLCPT

MIBiG 4.0 matches for allorf_0819396_0819626

16.7%

BGC0001155.5 (AGY49587.1):

Thiopeptide: GE2270

WCTSCS

+C SCS

FCCSCS

allorf_0820552_0820677

Leader:

MVAQLVEQRIEAPCVGSSTLSHAIYGG

Core:

IAKWLNATDCKSVP

Core with dehydrations:

IAKWLNADhbDCysKDhaVP

antiSMASH-DB 4.0 matches for allorf_0820552_0820677

100.0%

NZ_AP026714.1and 15 others:

Lanthipeptides: allorf_1211804_1211929_lanthipeptide

IAKWLNATDCKSVP

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.86 out of 25.88

Confidence: medium

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 29.31 out of 33.14

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 15.53 out of 18.16

Confidence: strong

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.10 out of 21.55

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.06 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.06 out of 26.06

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.94 out of 30.25

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 25.49 out of 30.25

Confidence: medium

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 23.31 out of 27.04

Confidence: medium

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.56 out of 25.88

Confidence: medium

Additional weak hits (11):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 26.37 out of 31.73

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.58 out of 19.52

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.26 out of 23.43

Confidence: weak

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 20.16 out of 29.72

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.22 out of 20.01

Confidence: weak

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 16.58 out of 20.47

Confidence: weak

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 20.81 out of 29.72

Confidence: weak

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 19.89 out of 29.51

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 16.99 out of 30.12

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 17.35 out of 30.12

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 24.25 out of 36.53

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

MK744_RS03985 - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 3317.4 Da

Molecular weight: 3319.7 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3337.7 Da N = 1; 3355.7 Da N = 2; 3373.7 Da N = 3

MK744_RS03990 - Class II

Cleavage pHMM score: -1.70

RODEO score: 0

Monoisotopic mass: 2997.6 Da

Molecular weight: 2999.5 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3017.5 Da N = 1; 3035.5 Da N = 2; 3053.5 Da N = 3; 3071.6 Da N = 4; 3089.6 Da N = 5; 3107.6 Da N = 6; 3125.6 Da N = 7

allorf_0819396_0819626 - Class II

Cleavage pHMM score: -5.70

RODEO score: 0

Monoisotopic mass: 2448.2 Da

Molecular weight: 2449.8 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2467.8 Da N = 1; 2485.8 Da N = 2; 2503.8 Da N = 3; 2521.9 Da N = 4

allorf_0820552_0820677 - Class II

Cleavage pHMM score: -3.90

RODEO score: 0

Monoisotopic mass: 1508.8 Da

Molecular weight: 1509.8 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1527.8 Da N = 1

MK744_RS03985 - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 3317.4 Da

Molecular weight: 3319.7 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3337.7 Da N = 1; 3355.7 Da N = 2; 3373.7 Da N = 3

MK744_RS03990 - Class II

Cleavage pHMM score: -1.70

RODEO score: 0

Monoisotopic mass: 2997.6 Da

Molecular weight: 2999.5 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3017.5 Da N = 1; 3035.5 Da N = 2; 3053.5 Da N = 3; 3071.6 Da N = 4; 3089.6 Da N = 5; 3107.6 Da N = 6; 3125.6 Da N = 7

allorf_0815941_0816015 - Class II

Cleavage pHMM score: -3.80

RODEO score: 0

Monoisotopic mass: 1477.8 Da

Molecular weight: 1478.7 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1496.7 Da N = 1; 1514.7 Da N = 2

allorf_0817095_0817172 - Class II

Cleavage pHMM score: -6.60

RODEO score: 0

Monoisotopic mass: 1451.7 Da

Molecular weight: 1452.6 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1470.6 Da N = 1; 1488.6 Da N = 2; 1506.6 Da N = 3

allorf_0817463_0817624 - Class II

Cleavage pHMM score: -6.20

RODEO score: 0

Monoisotopic mass: 2922.6 Da

Molecular weight: 2924.3 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2942.3 Da N = 1; 2960.4 Da N = 2; 2978.4 Da N = 3; 2996.4 Da N = 4; 3014.4 Da N = 5

allorf_0817521_0817646 - Class II

Cleavage pHMM score: -7.20

RODEO score: 0

Monoisotopic mass: 3303.8 Da

Molecular weight: 3305.9 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3323.9 Da N = 1

allorf_0817696_0817887 - Class II

Cleavage pHMM score: -5.10

RODEO score: 0

Monoisotopic mass: 5132.6 Da

Molecular weight: 5135.8 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 5153.8 Da N = 1; 5171.8 Da N = 2; 5189.8 Da N = 3

allorf_0819132_0819293 - Class II

Cleavage pHMM score: -6.00

RODEO score: 0

Monoisotopic mass: 4103.0 Da

Molecular weight: 4105.4 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 4123.4 Da N = 1; 4141.5 Da N = 2; 4159.5 Da N = 3

allorf_0819396_0819626 - Class II

Cleavage pHMM score: -5.70

RODEO score: 0

Monoisotopic mass: 2448.2 Da

Molecular weight: 2449.8 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2467.8 Da N = 1; 2485.8 Da N = 2; 2503.8 Da N = 3; 2521.9 Da N = 4

allorf_0820552_0820677 - Class II

Cleavage pHMM score: -3.90

RODEO score: 0

Monoisotopic mass: 1508.8 Da

Molecular weight: 1509.8 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1527.8 Da N = 1

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
ArcA	Repressor of carbon oxidation
ColR	Phenol-responsive regulator
DasR	N-acetylglucosamine dependent repressor
MogR	Repressor of flagellar motility genes
PsrA	Oleic acid responsive regulator
ZuR variant 2	Zinc-responsive repressor

NZ_CP092907.1 - Region 4 - cyclic-lactone-autoinducer

Download region GenBank file

Download region SVG

Location: 1,566,535 - 1,587,263 nt. (total: 20,729 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001291.3	0.41	ribosomal	enterocin NKR-5-3B	Enterococcus faecium
BGC0001948.3	0.37	other (other)	naseseazine C, C3-aryl pyrroloindolines	Streptomyces sp.
BGC0000046.4	0.35	PKS	depudecin	Alternaria brassicicola
BGC0002227.3	0.31	NRPS	AKML B, AKML D, AKML A, AKML C	Aspergillus luchuensis IFO 4308
BGC0002667.2	0.30	ribosomal	estericin A	Clostridium estertheticum
BGC0001246.3	0.30	PKS	trans-resorcylide	Sarocladium zeae
BGC0000688.4	0.29	terpene	copalyl diphosphate	Diaporthe amygdali
BGC0001954.2	0.28	NRPS, PKS	wortmanamide A, wortmanamide B	Talaromyces wortmannii
BGC0001366.5	0.27	PKS	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2
BGC0002058.3	0.27	NRPS, PKS	mutanocyclin	Streptococcus mutans B04Sm5

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001291.3	0.41	ribosomal	enterocin NKR-5-3B	Enterococcus faecium
BGC0001948.3	0.37	other (other)	naseseazine C, C3-aryl pyrroloindolines	Streptomyces sp.
BGC0000046.4	0.35	PKS	depudecin	Alternaria brassicicola
BGC0002227.3	0.31	NRPS	AKML B, AKML D, AKML A, AKML C	Aspergillus luchuensis IFO 4308
BGC0002667.2	0.30	ribosomal	estericin A	Clostridium estertheticum
BGC0001246.3	0.30	PKS	trans-resorcylide	Sarocladium zeae
BGC0000688.4	0.29	terpene	copalyl diphosphate	Diaporthe amygdali
BGC0001954.2	0.28	NRPS, PKS	wortmanamide A, wortmanamide B	Talaromyces wortmannii
BGC0001366.5	0.27	PKS	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2
BGC0002058.3	0.27	NRPS, PKS	mutanocyclin	Streptococcus mutans B04Sm5

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 28.99 out of 30.25

Confidence: strong

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.08 out of 23.79

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.55 out of 19.26

Confidence: medium

Additional weak hits (1):

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 20.68 out of 29.72

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
ColR	Phenol-responsive regulator
IolR	Regulator of the inositol catabolism