GCF_019331795.1 - 7 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_JAHPZL010000015.1 (Austwickia sp. TVS 96-490-7B)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 7.1	RiPP-like	8,122	18,409

NZ_JAHPZL010000024.1 (Austwickia sp. TVS 96-490-7B)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 14.1	NI-siderophore	1	21,958	Low	peucechelin	NRPS:Type I

NZ_JAHPZL010000025.1 (Austwickia sp. TVS 96-490-7B)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 15.1	RiPP-like	1	11,640

NZ_JAHPZL010000003.1 (Austwickia sp. TVS 96-490-7B)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 19.1	CDPS	537,054	557,803

NZ_JAHPZL010000004.1 (Austwickia sp. TVS 96-490-7B)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 29.1	lanthipeptide-class-ii	326,570	349,272

NZ_JAHPZL010000007.1 (Austwickia sp. TVS 96-490-7B)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 47.1	RiPP-like	16,628	28,025

NZ_JAHPZL010000008.1 (Austwickia sp. TVS 96-490-7B)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 48.1	terpene-precursor	130,800	151,885

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 7.1	RiPP-like	8,122	18,409
Region 14.1	NI-siderophore	1	21,958	Low	peucechelin	NRPS:Type I
Region 15.1	RiPP-like	1	11,640
Region 19.1	CDPS	537,054	557,803
Region 29.1	lanthipeptide-class-ii	326,570	349,272
Region 47.1	RiPP-like	16,628	28,025
Region 48.1	terpene-precursor	130,800	151,885

No secondary metabolite regions were found in these records:: NZ_JAHPZL010000058.1 (Austwickia sp. TVS 96-490-7B); NZ_JAHPZL010000001.1 (Austwickia sp. TVS 96-490-7B); NZ_JAHPZL010000010.1 (Austwickia sp. TVS 96-490-7B); NZ_JAHPZL010000011.1 (Austwickia sp. TVS 96-490-7B); NZ_JAHPZL010000013.1 (Austwickia sp. TVS 96-490-7B); NZ_JAHPZL010000014.1 (Austwickia sp. TVS 96-490-7B); NZ_JAHPZL010000017.1 (Austwickia sp. TVS 96-490-7B); NZ_JAHPZL010000019.1 (Austwickia sp. TVS 96-490-7B); NZ_JAHPZL010000002.1 (Austwickia sp. TVS 96-490-7B); NZ_JAHPZL010000020.1 (Austwickia sp. TVS 96-490-7B); NZ_JAHPZL010000022.1 (Austwickia sp. TVS 96-490-7B); NZ_JAHPZL010000023.1 (Austwickia sp. TVS 96-490-7B); NZ_JAHPZL010000027.1 (Austwickia sp. TVS 96-490-7B); NZ_JAHPZL010000028.1 (Austwickia sp. TVS 96-490-7B); NZ_JAHPZL010000029.1 (Austwickia sp. TVS 96-490-7B); NZ_JAHPZL010000030.1 (Austwickia sp. TVS 96-490-7B); NZ_JAHPZL010000031.1 (Austwickia sp. TVS 96-490-7B); NZ_JAHPZL010000032.1 (Austwickia sp. TVS 96-490-7B); NZ_JAHPZL010000033.1 (Austwickia sp. TVS 96-490-7B); NZ_JAHPZL010000034.1 (Austwickia sp. TVS 96-490-7B); NZ_JAHPZL010000036.1 (Austwickia sp. TVS 96-490-7B); NZ_JAHPZL010000037.1 (Austwickia sp. TVS 96-490-7B); NZ_JAHPZL010000038.1 (Austwickia sp. TVS 96-490-7B); NZ_JAHPZL010000039.1 (Austwickia sp. TVS 96-490-7B); NZ_JAHPZL010000040.1 (Austwickia sp. TVS 96-490-7B); NZ_JAHPZL010000041.1 (Austwickia sp. TVS 96-490-7B); NZ_JAHPZL010000042.1 (Austwickia sp. TVS 96-490-7B); NZ_JAHPZL010000043.1 (Austwickia sp. TVS 96-490-7B); NZ_JAHPZL010000044.1 (Austwickia sp. TVS 96-490-7B); NZ_JAHPZL010000045.1 (Austwickia sp. TVS 96-490-7B); NZ_JAHPZL010000047.1 (Austwickia sp. TVS 96-490-7B); NZ_JAHPZL010000048.1 (Austwickia sp. TVS 96-490-7B); NZ_JAHPZL010000005.1 (Austwickia sp. TVS 96-490-7B); NZ_JAHPZL010000049.1 (Austwickia sp. TVS 96-490-7B); NZ_JAHPZL010000050.1 (Austwickia sp. TVS 96-490-7B); NZ_JAHPZL010000051.1 (Austwickia sp. TVS 96-490-7B); NZ_JAHPZL010000052.1 (Austwickia sp. TVS 96-490-7B); NZ_JAHPZL010000053.1 (Austwickia sp. TVS 96-490-7B); NZ_JAHPZL010000056.1 (Austwickia sp. TVS 96-490-7B); NZ_JAHPZL010000057.1 (Austwickia sp. TVS 96-490-7B); NZ_JAHPZL010000006.1 (Austwickia sp. TVS 96-490-7B)

Compact view

NZ_JAHPZL010000015.1 - Region 1 - RiPP-like

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Location: 8,122 - 18,409 nt. (total: 10,288 nt) Show pHMM detection rules used

Region on contig edge.

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

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SubClusterBlast

TFBS Finder

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001639.3	0.40	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0002049.3	0.40	ribosomal	microviridin N9, microviridin N8, microviridin N7, microviridin N6, microviridin N5, microviridin N4, microviridin N3	Nostoc punctiforme PCC 73102
BGC0000513.3	0.36	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000551.5	0.36	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000504.5	0.35	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001576.3	0.35	ribosomal	divamide A	Prochloron didemni
BGC0002698.2	0.35	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000500.5	0.34	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0001748.4	0.33	NRPS, PKS	pseudospumigin A, pseudospumigin B, pseudospumigin C, pseudospumigin D, pseudospumigin E, pseudospumigin F	Nostoc sp. CENA543
BGC0000351.5	0.32	NRPS	exochelin	Mycolicibacterium smegmatis MC2 155

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001639.3	0.40	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0002049.3	0.40	ribosomal	microviridin N9, microviridin N8, microviridin N7, microviridin N6, microviridin N5, microviridin N4, microviridin N3	Nostoc punctiforme PCC 73102
BGC0000513.3	0.36	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000551.5	0.36	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000504.5	0.35	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001576.3	0.35	ribosomal	divamide A	Prochloron didemni
BGC0002698.2	0.35	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000500.5	0.34	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0001748.4	0.33	NRPS, PKS	pseudospumigin A, pseudospumigin B, pseudospumigin C, pseudospumigin D, pseudospumigin E, pseudospumigin F	Nostoc sp. CENA543
BGC0000351.5	0.32	NRPS	exochelin	Mycolicibacterium smegmatis MC2 155

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 19.35 out of 20.47

Confidence: strong

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 28.54 out of 32.93

Confidence: medium

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 31.21 out of 32.38

Confidence: strong

Additional weak hits (3):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.63 out of 30.25

Confidence: weak

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 25.23 out of 32.38

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.52 out of 18.57

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CsoR	Copper-responsive repressor
RicR	Copper-responsive regulator
VqsM	Regulator of quorum-sensing signalling systems

NZ_JAHPZL010000024.1 - Region 1 - NI-siderophore

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Location: 1 - 21,958 nt. (total: 21,958 nt) Show pHMM detection rules used

Region on contig edge.

NI-siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

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Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: methyltransferase

KEM60_RS14840: methyltransferase

smcogs: SMCOG1089: methyltransferase

Lyases: decarboxylase lyase

KEM60_RS14815: diaminopimelate decarboxylase

smcogs: SMCOG1264: diaminopimelate decarboxylase

KEM60_RS14835: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000946.5	0.77	other (other)	vibrioferrin	Vibrio parahaemolyticus
BGC0001408.5	0.70	other (other)	xanthoferrin	Xanthomonas oryzae pv. oryzae KACC 10331
BGC0002527.2	0.69	other (other)	vibrioferrin	Azotobacter vinelandii CA
BGC0000947.5	0.53	other (other)	vibrioferrin	Vibrio alginolyticus
BGC0000943.5	0.48	other (other)	staphyloferrin B	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0002681.3	0.48	other (other)	rhizoferrin	Francisella tularensis subsp. tularensis SCHU S4
BGC0000942.4	0.47	other (other)	petrobactin	Bacillus anthracis str. Ames
BGC0001870.3	0.47	other (other)	putrebactin, avaroferrin	Xenorhabdus budapestensis
BGC0002683.2	0.45	NRPS	schizokinen	Nostoc sp. PCC 7120 = FACHB-418
BGC0001779.5	0.40	ribosomal	siamycin	Streptomyces nodosus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000946.5	0.77	other (other)	vibrioferrin	Vibrio parahaemolyticus
BGC0001408.5	0.70	other (other)	xanthoferrin	Xanthomonas oryzae pv. oryzae KACC 10331
BGC0002527.2	0.69	other (other)	vibrioferrin	Azotobacter vinelandii CA
BGC0000947.5	0.53	other (other)	vibrioferrin	Vibrio alginolyticus
BGC0000943.5	0.48	other (other)	staphyloferrin B	Staphylococcus aureus subsp. aureus NCTC 8325
BGC0002681.3	0.48	other (other)	rhizoferrin	Francisella tularensis subsp. tularensis SCHU S4
BGC0000942.4	0.47	other (other)	petrobactin	Bacillus anthracis str. Ames
BGC0001870.3	0.47	other (other)	putrebactin, avaroferrin	Xenorhabdus budapestensis
BGC0002683.2	0.45	NRPS	schizokinen	Nostoc sp. PCC 7120 = FACHB-418
BGC0001779.5	0.40	ribosomal	siamycin	Streptomyces nodosus

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 34.36 out of 36.53

Confidence: strong

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 32.03 out of 36.53

Confidence: strong

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 28.73 out of 36.53

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 27.73 out of 36.53

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.92 out of 23.79

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.55 out of 23.79

Confidence: medium

Additional weak hits (4):

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.42 out of 26.85

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.56 out of 39.62

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.37 out of 39.62

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.84 out of 28.19

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
DmdR1	Iron(II)-dependent repressor
IolR	Regulator of the inositol catabolism

NZ_JAHPZL010000025.1 - Region 1 - RiPP-like

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Location: 1 - 11,640 nt. (total: 11,640 nt) Show pHMM detection rules used

Region on contig edge.

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001485.4	0.38	other (other)	chuangxinmycin	Actinoplanes tsinanensis
BGC0001587.5	0.34	other (other)	ethylenediaminesuccinic acid hydroxyarginine (EDHA)	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000468.5	0.31	ribosomal	bottromycin A2	Streptomyces bottropensis DSM40262
BGC0001157.6	0.31	ribosomal	bottromycin A2	Streptomyces scabiei 87.22
BGC0000470.6	0.31	ribosomal	bottromycin D	Streptomyces sp. WMMB272
BGC0000469.6	0.29	ribosomal	bottromycin A2	Streptomyces sp. BC16019
BGC0001221.5	0.29	other (phenazine)	marinophenazine A, phenaziterpene A	Streptomyces sp. CNQ-509
BGC0000932.5	0.28	other (other)	tropodithietic acid, hydroxytropodithietic acid	Phaeobacter inhibens DSM 17395
BGC0002567.2	0.28	other (other)	EDHA	Streptomyces sp. MA5143a
BGC0001148.5	0.28	NRPS, ribosomal	pheganomycin	Streptomyces cirratus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001485.4	0.38	other (other)	chuangxinmycin	Actinoplanes tsinanensis
BGC0001587.5	0.34	other (other)	ethylenediaminesuccinic acid hydroxyarginine (EDHA)	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000468.5	0.31	ribosomal	bottromycin A2	Streptomyces bottropensis DSM40262
BGC0001157.6	0.31	ribosomal	bottromycin A2	Streptomyces scabiei 87.22
BGC0000470.6	0.31	ribosomal	bottromycin D	Streptomyces sp. WMMB272
BGC0000469.6	0.29	ribosomal	bottromycin A2	Streptomyces sp. BC16019
BGC0001221.5	0.29	other (phenazine)	marinophenazine A, phenaziterpene A	Streptomyces sp. CNQ-509
BGC0000932.5	0.28	other (other)	tropodithietic acid, hydroxytropodithietic acid	Phaeobacter inhibens DSM 17395
BGC0002567.2	0.28	other (other)	EDHA	Streptomyces sp. MA5143a
BGC0001148.5	0.28	NRPS, ribosomal	pheganomycin	Streptomyces cirratus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (2):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.20 out of 29.38

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.03 out of 26.85

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description

NZ_JAHPZL010000003.1 - Region 1 - CDPS

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Location: 537,054 - 557,803 nt. (total: 20,750 nt) Show pHMM detection rules used

CDPS: CDPS

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase

KEM60_RS05025: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002103.2	0.60	other (other)	pulcherriminic acid	Bacillus subtilis subsp. subtilis str. 168
BGC0002073.3	0.42	NRPS	dehydroxynocardamine	Corynebacterium propinquum
BGC0002698.2	0.40	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0002490.2	0.38	other (other)	yersinopine	Yersinia pestis CO92
BGC0000947.5	0.38	other (other)	vibrioferrin	Vibrio alginolyticus
BGC0002531.3	0.37	NRPS	cepaciachelin	Burkholderia ambifaria AMMD
BGC0000410.5	0.36	NRPS	pseudomonine	Pseudomonas fluorescens
BGC0000939.5	0.36	other (other)	aerobactin	Grimontia hollisae
BGC0001498.5	0.35	other (other)	aerobactin	Xenorhabdus szentirmaii DSM 16338
BGC0001392.5	0.35	ribosomal	pinensins	Chitinophaga pinensis DSM 2588

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002103.2	0.60	other (other)	pulcherriminic acid	Bacillus subtilis subsp. subtilis str. 168
BGC0002073.3	0.42	NRPS	dehydroxynocardamine	Corynebacterium propinquum
BGC0002698.2	0.40	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0002490.2	0.38	other (other)	yersinopine	Yersinia pestis CO92
BGC0000947.5	0.38	other (other)	vibrioferrin	Vibrio alginolyticus
BGC0002531.3	0.37	NRPS	cepaciachelin	Burkholderia ambifaria AMMD
BGC0000410.5	0.36	NRPS	pseudomonine	Pseudomonas fluorescens
BGC0000939.5	0.36	other (other)	aerobactin	Grimontia hollisae
BGC0001498.5	0.35	other (other)	aerobactin	Xenorhabdus szentirmaii DSM 16338
BGC0001392.5	0.35	ribosomal	pinensins	Chitinophaga pinensis DSM 2588

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.23 out of 27.78

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.26 out of 28.19

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16

Confidence: strong

Additional weak hits (3):

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 20.69 out of 35.63

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.27 out of 18.57

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 25.16 out of 36.53

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ZuR variant 1	Zinc-responsive repressor

NZ_JAHPZL010000004.1 - Region 1 - lanthipeptide-class-ii

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Location: 326,570 - 349,272 nt. (total: 22,703 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

KEM60_RS07370: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000503.5	0.52	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0000528.5	0.51	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0002346.3	0.44	ribosomal	kyamicin	Saccharopolyspora sp.
BGC0000516.4	0.44	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0001210.5	0.44	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0002110.3	0.44	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000527.5	0.44	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0002700.2	0.43	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0002306.2	0.43	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000504.5	0.43	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000503.5	0.52	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0000528.5	0.51	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0002346.3	0.44	ribosomal	kyamicin	Saccharopolyspora sp.
BGC0000516.4	0.44	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0001210.5	0.44	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0002110.3	0.44	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000527.5	0.44	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0002700.2	0.43	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0002306.2	0.43	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000504.5	0.43	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for KEM60_RS07370

allorf_329221_329397

Leader:

MSCRGRQHPSRGA

Core:

WALWGIPGEGRKFTFRGQHLEPDRTQVRRPASSGCVYLSGLTSPT

Core with dehydrations:

WALWGIPGEGRKFDhbFRGQHLEPDRDhbQVRRPADhaDhaGCysVYLDhaGLDhbDhaPDhb

antiSMASH-DB 4.0 matches for allorf_329221_329397

100.0%

NZ_JAHPZL010000004.1:

Lanthipeptides: allorf_329221_329397_lanthipeptide

1

WALWGIPGEGRKFTFRGQHLEPDRTQVRRPASSGCVYLSGLTSPT

45

WALWGIPGEGRKFTFRGQHLEPDRTQVRRPASSGCVYLSGLTSPT

1

WALWGIPGEGRKFTFRGQHLEPDRTQVRRPASSGCVYLSGLTSPT

45

15.6%

NZ_JANVAG010000003.1:

Lanthipeptides: allorf_436904_437122_lanthipeptide

33

SGCVYLSGLTSPT

45

SGCV+ S +T P+

2

SGCVFESAITDPS

14

allorf_329919_330011

Leader:

MWQDRRSGSFGG

Core:

SVCRRRVAGGPDADPAVT

Core with dehydrations:

DhaVCysRRRVAGGPDADPAVDhb

antiSMASH-DB 4.0 matches for allorf_329919_330011

100.0%

NZ_JAHPZL010000004.1:

Lanthipeptides: allorf_329919_330011_lanthipeptide

1

SVCRRRVAGGPDADPAVT

18

SVCRRRVAGGPDADPAVT

1

SVCRRRVAGGPDADPAVT

18

35.0%

NZ_BMTW01000001.1:

Lanthipeptides: allorf_0729166_0729378_lanthipeptide

4

RRRVAGGPDAD

14

RR G PDAD

9

RRHRTGWPDAD

19

35.0%

NZ_CP067395.1:

Lanthipeptides: allorf_0865489_0865689_lanthipeptide

4

RRRVAGGPDADP

15

RRRV+ P A P

5

RRRVSAHPRAQP

16

with 2 more sequence matches

33.3%

NZ_CP010836.1:

Lassopeptides: TS85_RS25615_lassopeptide

7

VAGGPDAD

14

+ GGPDAD

3

IVGGPDAD

10

32.0%

NZ_CP050504.1:

Lanthipeptides: allorf_8941092_8941208_lanthipeptide

2

VCRRRVAGGPD

12

VCRR AGG D

4

VCRRGRAGGAD

14

MIBiG 4.0 matches for allorf_329919_330011

13.5%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

14

DPAVT

18

DPAVT

2

DPAVT

6

allorf_329924_330103

Leader:

MTGFLVRQGRDRKSGFGA

Core:

ASGSFSSVASVNGCGRIGDQDLLADQCVVGVSRAALMPILP

Core with dehydrations:

ADhaGDhaFDhaDhaVADhaVNGCysGRIGDQDLLADQCysVVGVDhaRAALMPILP

antiSMASH-DB 4.0 matches for allorf_329924_330103

100.0%

NZ_JAHPZL010000004.1:

Lanthipeptides: allorf_329924_330103_lanthipeptide

1

ASGSFSSVASVNGCGRIGDQDLLADQCVVGVSRAALMPILP

41

ASGSFSSVASVNGCGRIGDQDLLADQCVVGVSRAALMPILP

1

ASGSFSSVASVNGCGRIGDQDLLADQCVVGVSRAALMPILP

41

allorf_329941_330090

Leader:

MCVKAETGRVASELRAGVFHLWRLLTGVAGS

Core:

AIRIFWRISVSSACRGRP

Core with dehydrations:

AIRIFWRIDhaVDhaDhaACysRGRP

antiSMASH-DB 4.0 matches for allorf_329941_330090

100.0%

NZ_JAHPZL010000004.1:

Lanthipeptides: allorf_329941_330090_lanthipeptide

1

AIRIFWRISVSSACRGRP

18

AIRIFWRISVSSACRGRP

1

AIRIFWRISVSSACRGRP

18

20.8%

NZ_JAAXRC010000001.1:

Lanthipeptides: HFO56_RS03105_lanthipeptide

1

AIRIFWRISVSSACRGR

17

A+ + W S +S C

4

ALGLMWDASCASTCDSN

20

20.0%

NZ_SLWS01000023.1:

Lanthipeptides: allorf_57815_57919_lanthipeptide

3

RIFWRISVSSACR

15

R +WR+ CR

3

RSYWRVRFDGNCR

15

allorf_330105_330254

Leader:

MSHSAGDVSDDCPISPYHDGAIAGH

Core:

RGRWGSPVPRDPNRTHDDCGMLLR

Core with dehydrations:

RGRWGDhaPVPRDPNRDhbHDDCysGMLLR

antiSMASH-DB 4.0 matches for allorf_330105_330254

100.0%

NZ_JAHPZL010000004.1:

Lanthipeptides: allorf_330105_330254_lanthipeptide

1

RGRWGSPVPRDPNRTHDDCGMLLR

24

RGRWGSPVPRDPNRTHDDCGMLLR

1

RGRWGSPVPRDPNRTHDDCGMLLR

24

27.3%

NZ_JAHUVY010000001.1and 1 other:

NZ_JAHUVY010000001.1 Lanthipeptides: allorf_0075041_0075244_lanthipeptide

Lanthipeptides: allorf_0075041_0075244_lanthipeptide

2

GRWGSPVP-----RDPNRTHDDCGMLLR

24

GR G P P R P R H GM +R

5

GRDGPPSPPCGWARTPPRGHSGTGMPVR

32

23.1%

NZ_JACJHX010000002.1:

Lassopeptides: HNP81_RS04455_lassopeptide

5

GSPVPRDPN

13

GSP+P D N

11

GSPIPVDEN

19

with 2 more sequence matches

20.8%

NZ_PGGW01000010.1and 1 other:

NZ_PGGW01000010.1 Lanthipeptides: CUT44_RS02535_lanthipeptide

Lanthipeptides: CUT44_RS02535_lanthipeptide

13

NRTHDDCG

20

N+T D+CG

3

NKTSDNCG

10

16.7%

NZ_OCTY01000002.1:

Lanthipeptides: allorf_0873960_0874184_lanthipeptide

4

WGSPVPRDPNR

14

+ SP PRDP R

24

YTSPRPRDPTR

34

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 23.38 out of 29.72

Confidence: medium

Additional weak hits (4):

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.32 out of 21.55

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 19.91 out of 29.25

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 19.72 out of 36.54

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.21 out of 26.33

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

allorf_329221_329397 - Class II

Cleavage pHMM score: -5.10

RODEO score: 0

Monoisotopic mass: 4869.6 Da

Molecular weight: 4872.5 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 4890.5 Da N = 1; 4908.5 Da N = 2; 4926.5 Da N = 3; 4944.5 Da N = 4; 4962.6 Da N = 5; 4980.6 Da N = 6; 4998.6 Da N = 7

allorf_329919_330011 - Class II

Cleavage pHMM score: -2.70

RODEO score: 0

Monoisotopic mass: 1789.9 Da

Molecular weight: 1791.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1809.0 Da N = 1

allorf_329924_330103 - Class II

Cleavage pHMM score: -6.40

RODEO score: 0

Monoisotopic mass: 3952.0 Da

Molecular weight: 3954.5 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3972.5 Da N = 1; 3990.5 Da N = 2; 4008.5 Da N = 3; 4026.6 Da N = 4

allorf_329941_330090 - Class II

Cleavage pHMM score: -5.30

RODEO score: 0

Monoisotopic mass: 2020.1 Da

Molecular weight: 2021.4 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2039.4 Da N = 1; 2057.4 Da N = 2

allorf_330105_330254 - Class II

Cleavage pHMM score: -6.80

RODEO score: 0

Monoisotopic mass: 2754.4 Da

Molecular weight: 2756.1 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2774.1 Da N = 1

TFBS definitions

Regulator	Description
NtrC	Nitrogen regulatory protein C

NZ_JAHPZL010000007.1 - Region 1 - RiPP-like

Download region GenBank file

Download region SVG

Location: 16,628 - 28,025 nt. (total: 11,398 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002115.3	0.55	ribosomal	streptamidine	Streptomyces albidoflavus J1074
BGC0000513.3	0.50	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0001638.4	0.50	ribosomal	klebsazolicin	Klebsiella pneumoniae subsp. ozaenae
BGC0002698.2	0.47	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0002306.2	0.43	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000558.5	0.42	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0000551.5	0.42	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0001555.4	0.42	ribosomal	colicin V	Escherichia coli chi7122
BGC0000519.4	0.41	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000590.5	0.41	ribosomal	microcin N	Escherichia coli

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002115.3	0.55	ribosomal	streptamidine	Streptomyces albidoflavus J1074
BGC0000513.3	0.50	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0001638.4	0.50	ribosomal	klebsazolicin	Klebsiella pneumoniae subsp. ozaenae
BGC0002698.2	0.47	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0002306.2	0.43	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000558.5	0.42	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0000551.5	0.42	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0001555.4	0.42	ribosomal	colicin V	Escherichia coli chi7122
BGC0000519.4	0.41	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000590.5	0.41	ribosomal	microcin N	Escherichia coli

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

NZ_JAHPZL010000008.1 - Region 1 - terpene-precursor

Download region GenBank file

Download region SVG

Location: 130,800 - 151,885 nt. (total: 21,086 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: synthetase

KEM60_RS11235: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002309.2	0.38	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000677.5	0.34	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0000678.5	0.32	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001456.3	0.31	terpene	isorenieratene	Streptomyces argillaceus
BGC0001911.3	0.31	terpene	raimonol	Streptomyces anulatus
BGC0001910.4	0.30	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0002294.3	0.29	other (other)	streptozotocin	Streptomyces achromogenes subsp. streptozoticus
BGC0000665.5	0.28	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0000664.5	0.28	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001994.4	0.28	other (other)	β-ethynylserine	Streptomyces cattleya NRRL 8057 = DSM 46488

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002309.2	0.38	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000677.5	0.34	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0000678.5	0.32	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001456.3	0.31	terpene	isorenieratene	Streptomyces argillaceus
BGC0001911.3	0.31	terpene	raimonol	Streptomyces anulatus
BGC0001910.4	0.30	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0002294.3	0.29	other (other)	streptozotocin	Streptomyces achromogenes subsp. streptozoticus
BGC0000665.5	0.28	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0000664.5	0.28	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001994.4	0.28	other (other)	β-ethynylserine	Streptomyces cattleya NRRL 8057 = DSM 46488

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

KEM60_RS11235: PT_FPPS_like

Domain 1 (42 - 360): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 25.49 out of 29.65

Confidence: medium

Additional weak hits (3):

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 17.28 out of 27.78

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.31 out of 28.19

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.74 out of 24.78

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
LexA variant 1	Repressor of DNA damage response