Select genomic region:
Overview
7.1
14.1
15.1
19.1
29.1
47.1
48.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_JAHPZL010000015.1 (Austwickia sp. TVS 96-490-7B)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 7.1 | RiPP-like | 8,122 | 18,409 |

NZ_JAHPZL010000024.1 (Austwickia sp. TVS 96-490-7B)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 14.1 | NI-siderophore | 1 | 21,958 | Low | peucechelin | NRPS:Type I

NZ_JAHPZL010000025.1 (Austwickia sp. TVS 96-490-7B)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 15.1 | RiPP-like | 1 | 11,640 |

NZ_JAHPZL010000003.1 (Austwickia sp. TVS 96-490-7B)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 19.1 | CDPS | 537,054 | 557,803 |  |

NZ_JAHPZL010000004.1 (Austwickia sp. TVS 96-490-7B)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 29.1 | lanthipeptide-class-ii | 326,570 | 349,272 |

NZ_JAHPZL010000007.1 (Austwickia sp. TVS 96-490-7B)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 47.1 | RiPP-like | 16,628 | 28,025 |

NZ_JAHPZL010000008.1 (Austwickia sp. TVS 96-490-7B)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 48.1 | terpene-precursor | 130,800 | 151,885 |  |

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 7.1 | RiPP-like | 8,122 | 18,409 |
Region 14.1 | NI-siderophore | 1 | 21,958 | Low | peucechelin | NRPS:Type I
Region 15.1 | RiPP-like | 1 | 11,640 |
Region 19.1 | CDPS | 537,054 | 557,803 |  |
Region 29.1 | lanthipeptide-class-ii | 326,570 | 349,272 |
Region 47.1 | RiPP-like | 16,628 | 28,025 |
Region 48.1 | terpene-precursor | 130,800 | 151,885 |  |

No secondary metabolite regions were found in these records:
  NZ_JAHPZL010000058.1 (Austwickia sp. TVS 96-490-7B)
  NZ_JAHPZL010000001.1 (Austwickia sp. TVS 96-490-7B)
  NZ_JAHPZL010000010.1 (Austwickia sp. TVS 96-490-7B)
  NZ_JAHPZL010000011.1 (Austwickia sp. TVS 96-490-7B)
  NZ_JAHPZL010000013.1 (Austwickia sp. TVS 96-490-7B)
  NZ_JAHPZL010000014.1 (Austwickia sp. TVS 96-490-7B)
  NZ_JAHPZL010000017.1 (Austwickia sp. TVS 96-490-7B)
  NZ_JAHPZL010000019.1 (Austwickia sp. TVS 96-490-7B)
  NZ_JAHPZL010000002.1 (Austwickia sp. TVS 96-490-7B)
  NZ_JAHPZL010000020.1 (Austwickia sp. TVS 96-490-7B)
  NZ_JAHPZL010000022.1 (Austwickia sp. TVS 96-490-7B)
  NZ_JAHPZL010000023.1 (Austwickia sp. TVS 96-490-7B)
  NZ_JAHPZL010000027.1 (Austwickia sp. TVS 96-490-7B)
  NZ_JAHPZL010000028.1 (Austwickia sp. TVS 96-490-7B)
  NZ_JAHPZL010000029.1 (Austwickia sp. TVS 96-490-7B)
  NZ_JAHPZL010000030.1 (Austwickia sp. TVS 96-490-7B)
  NZ_JAHPZL010000031.1 (Austwickia sp. TVS 96-490-7B)
  NZ_JAHPZL010000032.1 (Austwickia sp. TVS 96-490-7B)
  NZ_JAHPZL010000033.1 (Austwickia sp. TVS 96-490-7B)
  NZ_JAHPZL010000034.1 (Austwickia sp. TVS 96-490-7B)
  NZ_JAHPZL010000036.1 (Austwickia sp. TVS 96-490-7B)
  NZ_JAHPZL010000037.1 (Austwickia sp. TVS 96-490-7B)
  NZ_JAHPZL010000038.1 (Austwickia sp. TVS 96-490-7B)
  NZ_JAHPZL010000039.1 (Austwickia sp. TVS 96-490-7B)
  NZ_JAHPZL010000040.1 (Austwickia sp. TVS 96-490-7B)
  NZ_JAHPZL010000041.1 (Austwickia sp. TVS 96-490-7B)
  NZ_JAHPZL010000042.1 (Austwickia sp. TVS 96-490-7B)
  NZ_JAHPZL010000043.1 (Austwickia sp. TVS 96-490-7B)
  NZ_JAHPZL010000044.1 (Austwickia sp. TVS 96-490-7B)
  NZ_JAHPZL010000045.1 (Austwickia sp. TVS 96-490-7B)
  NZ_JAHPZL010000047.1 (Austwickia sp. TVS 96-490-7B)
  NZ_JAHPZL010000048.1 (Austwickia sp. TVS 96-490-7B)
  NZ_JAHPZL010000005.1 (Austwickia sp. TVS 96-490-7B)
  NZ_JAHPZL010000049.1 (Austwickia sp. TVS 96-490-7B)
  NZ_JAHPZL010000050.1 (Austwickia sp. TVS 96-490-7B)
  NZ_JAHPZL010000051.1 (Austwickia sp. TVS 96-490-7B)
  NZ_JAHPZL010000052.1 (Austwickia sp. TVS 96-490-7B)
  NZ_JAHPZL010000053.1 (Austwickia sp. TVS 96-490-7B)
  NZ_JAHPZL010000056.1 (Austwickia sp. TVS 96-490-7B)
  NZ_JAHPZL010000057.1 (Austwickia sp. TVS 96-490-7B)
  NZ_JAHPZL010000006.1 (Austwickia sp. TVS 96-490-7B)

Compact view
NZ_JAHPZL010000015.1 - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 8,122 - 18,409 nt. (total: 10,288 nt) Show pHMM detection rules used
Region on contig edge.
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001639.3 |  | 0.40 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0002049.3 |  | 0.40 | ribosomal | microviridin N9, microviridin N8, microviridin N7, microviridin N6, microviridin N5, microviridin N4, microviridin N3 | Nostoc punctiforme PCC 73102
BGC0000513.3 |  | 0.36 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0000551.5 |  | 0.36 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000504.5 |  | 0.35 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0001576.3 |  | 0.35 | ribosomal | divamide A | Prochloron didemni
BGC0002698.2 |  | 0.35 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0000500.5 |  | 0.34 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0001748.4 |  | 0.33 | NRPS, PKS | pseudospumigin A, pseudospumigin B, pseudospumigin C, pseudospumigin D, pseudospumigin E, pseudospumigin F | Nostoc sp. CENA543
BGC0000351.5 |  | 0.32 | NRPS | exochelin | Mycolicibacterium smegmatis MC2 155

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001639.3 |  | 0.40 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0002049.3 |  | 0.40 | ribosomal | microviridin N9, microviridin N8, microviridin N7, microviridin N6, microviridin N5, microviridin N4, microviridin N3 | Nostoc punctiforme PCC 73102
BGC0000513.3 |  | 0.36 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0000551.5 |  | 0.36 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000504.5 |  | 0.35 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0001576.3 |  | 0.35 | ribosomal | divamide A | Prochloron didemni
BGC0002698.2 |  | 0.35 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0000500.5 |  | 0.34 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0001748.4 |  | 0.33 | NRPS, PKS | pseudospumigin A, pseudospumigin B, pseudospumigin C, pseudospumigin D, pseudospumigin E, pseudospumigin F | Nostoc sp. CENA543
BGC0000351.5 |  | 0.32 | NRPS | exochelin | Mycolicibacterium smegmatis MC2 155

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 19.35 out of 20.47
Confidence: strong
RicR
Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 28.54 out of 32.93
Confidence: medium
CsoR
Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 31.21 out of 32.38
Confidence: strong
Additional weak hits (3):
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.63 out of 30.25
Confidence: weak
CsoR
Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 25.23 out of 32.38
Confidence: weak
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.52 out of 18.57
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CsoR | Copper-responsive repressor
RicR | Copper-responsive regulator
VqsM | Regulator of quorum-sensing signalling systems

NZ_JAHPZL010000024.1 - Region 1 - NI-siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 21,958 nt. (total: 21,958 nt) Show pHMM detection rules used
Region on contig edge.
NI-siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: methyltransferase
KEM60_RS14840: methyltransferase

smcogs
  SMCOG1089: methyltransferase

Lyases: decarboxylase lyase
KEM60_RS14815: diaminopimelate decarboxylase

smcogs
  SMCOG1264: diaminopimelate decarboxylase

KEM60_RS14835: argininosuccinate lyase/adenylosuccinate lyase

smcogs
  SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NI-siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000946.5 |  | 0.77 | other (other) | vibrioferrin | Vibrio parahaemolyticus
BGC0001408.5 |  | 0.70 | other (other) | xanthoferrin | Xanthomonas oryzae pv. oryzae KACC 10331
BGC0002527.2 |  | 0.69 | other (other) | vibrioferrin | Azotobacter vinelandii CA
BGC0000947.5 |  | 0.53 | other (other) | vibrioferrin | Vibrio alginolyticus
BGC0000943.5 |  | 0.48 | other (other) | staphyloferrin B | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0002681.3 |  | 0.48 | other (other) | rhizoferrin | Francisella tularensis subsp. tularensis SCHU S4
BGC0000942.4 |  | 0.47 | other (other) | petrobactin | Bacillus anthracis str. Ames
BGC0001870.3 |  | 0.47 | other (other) | putrebactin, avaroferrin | Xenorhabdus budapestensis
BGC0002683.2 |  | 0.45 | NRPS | schizokinen | Nostoc sp. PCC 7120 = FACHB-418
BGC0001779.5 |  | 0.40 | ribosomal | siamycin | Streptomyces nodosus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000946.5 |  | 0.77 | other (other) | vibrioferrin | Vibrio parahaemolyticus
BGC0001408.5 |  | 0.70 | other (other) | xanthoferrin | Xanthomonas oryzae pv. oryzae KACC 10331
BGC0002527.2 |  | 0.69 | other (other) | vibrioferrin | Azotobacter vinelandii CA
BGC0000947.5 |  | 0.53 | other (other) | vibrioferrin | Vibrio alginolyticus
BGC0000943.5 |  | 0.48 | other (other) | staphyloferrin B | Staphylococcus aureus subsp. aureus NCTC 8325
BGC0002681.3 |  | 0.48 | other (other) | rhizoferrin | Francisella tularensis subsp. tularensis SCHU S4
BGC0000942.4 |  | 0.47 | other (other) | petrobactin | Bacillus anthracis str. Ames
BGC0001870.3 |  | 0.47 | other (other) | putrebactin, avaroferrin | Xenorhabdus budapestensis
BGC0002683.2 |  | 0.45 | NRPS | schizokinen | Nostoc sp. PCC 7120 = FACHB-418
BGC0001779.5 |  | 0.40 | ribosomal | siamycin | Streptomyces nodosus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 34.36 out of 36.53
Confidence: strong
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 32.03 out of 36.53
Confidence: strong
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 28.73 out of 36.53
Confidence: medium
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 27.73 out of 36.53
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.92 out of 23.79
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.55 out of 23.79
Confidence: medium
Additional weak hits (4):
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.42 out of 26.85
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.56 out of 39.62
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.37 out of 39.62
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.84 out of 28.19
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
DmdR1 | Iron(II)-dependent repressor
IolR | Regulator of the inositol catabolism

NZ_JAHPZL010000025.1 - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 11,640 nt. (total: 11,640 nt) Show pHMM detection rules used
Region on contig edge.
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001485.4 |  | 0.38 | other (other) | chuangxinmycin | Actinoplanes tsinanensis
BGC0001587.5 |  | 0.34 | other (other) | ethylenediaminesuccinic acid hydroxyarginine (EDHA) | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000468.5 |  | 0.31 | ribosomal | bottromycin A2 | Streptomyces bottropensis DSM40262
BGC0001157.6 |  | 0.31 | ribosomal | bottromycin A2 | Streptomyces scabiei 87.22
BGC0000470.6 |  | 0.31 | ribosomal | bottromycin D | Streptomyces sp. WMMB272
BGC0000469.6 |  | 0.29 | ribosomal | bottromycin A2 | Streptomyces sp. BC16019
BGC0001221.5 |  | 0.29 | other (phenazine) | marinophenazine A, phenaziterpene A | Streptomyces sp. CNQ-509
BGC0000932.5 |  | 0.28 | other (other) | tropodithietic acid, hydroxytropodithietic acid | Phaeobacter inhibens DSM 17395
BGC0002567.2 |  | 0.28 | other (other) | EDHA | Streptomyces sp. MA5143a
BGC0001148.5 |  | 0.28 | NRPS, ribosomal | pheganomycin | Streptomyces cirratus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001485.4 |  | 0.38 | other (other) | chuangxinmycin | Actinoplanes tsinanensis
BGC0001587.5 |  | 0.34 | other (other) | ethylenediaminesuccinic acid hydroxyarginine (EDHA) | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0000468.5 |  | 0.31 | ribosomal | bottromycin A2 | Streptomyces bottropensis DSM40262
BGC0001157.6 |  | 0.31 | ribosomal | bottromycin A2 | Streptomyces scabiei 87.22
BGC0000470.6 |  | 0.31 | ribosomal | bottromycin D | Streptomyces sp. WMMB272
BGC0000469.6 |  | 0.29 | ribosomal | bottromycin A2 | Streptomyces sp. BC16019
BGC0001221.5 |  | 0.29 | other (phenazine) | marinophenazine A, phenaziterpene A | Streptomyces sp. CNQ-509
BGC0000932.5 |  | 0.28 | other (other) | tropodithietic acid, hydroxytropodithietic acid | Phaeobacter inhibens DSM 17395
BGC0002567.2 |  | 0.28 | other (other) | EDHA | Streptomyces sp. MA5143a
BGC0001148.5 |  | 0.28 | NRPS, ribosomal | pheganomycin | Streptomyces cirratus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
No hits above weak threshold.
Weak hits (2):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.20 out of 29.38
Confidence: weak
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.03 out of 26.85
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---

NZ_JAHPZL010000003.1 - Region 1 - CDPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 537,054 - 557,803 nt. (total: 20,750 nt) Show pHMM detection rules used
CDPS: CDPS

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxygenase
KEM60_RS05025: cytochrome P450

smcogs
  SMCOG1007: cytochrome P450

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | CDPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002103.2 |  | 0.60 | other (other) | pulcherriminic acid | Bacillus subtilis subsp. subtilis str. 168
BGC0002073.3 |  | 0.42 | NRPS | dehydroxynocardamine | Corynebacterium propinquum
BGC0002698.2 |  | 0.40 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0002490.2 |  | 0.38 | other (other) | yersinopine | Yersinia pestis CO92
BGC0000947.5 |  | 0.38 | other (other) | vibrioferrin | Vibrio alginolyticus
BGC0002531.3 |  | 0.37 | NRPS | cepaciachelin | Burkholderia ambifaria AMMD
BGC0000410.5 |  | 0.36 | NRPS | pseudomonine | Pseudomonas fluorescens
BGC0000939.5 |  | 0.36 | other (other) | aerobactin | Grimontia hollisae
BGC0001498.5 |  | 0.35 | other (other) | aerobactin | Xenorhabdus szentirmaii DSM 16338
BGC0001392.5 |  | 0.35 | ribosomal | pinensins | Chitinophaga pinensis DSM 2588

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002103.2 |  | 0.60 | other (other) | pulcherriminic acid | Bacillus subtilis subsp. subtilis str. 168
BGC0002073.3 |  | 0.42 | NRPS | dehydroxynocardamine | Corynebacterium propinquum
BGC0002698.2 |  | 0.40 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0002490.2 |  | 0.38 | other (other) | yersinopine | Yersinia pestis CO92
BGC0000947.5 |  | 0.38 | other (other) | vibrioferrin | Vibrio alginolyticus
BGC0002531.3 |  | 0.37 | NRPS | cepaciachelin | Burkholderia ambifaria AMMD
BGC0000410.5 |  | 0.36 | NRPS | pseudomonine | Pseudomonas fluorescens
BGC0000939.5 |  | 0.36 | other (other) | aerobactin | Grimontia hollisae
BGC0001498.5 |  | 0.35 | other (other) | aerobactin | Xenorhabdus szentirmaii DSM 16338
BGC0001392.5 |  | 0.35 | ribosomal | pinensins | Chitinophaga pinensis DSM 2588

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.23 out of 27.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.26 out of 28.19
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16
Confidence: strong
Additional weak hits (3):
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 20.69 out of 35.63
Confidence: weak
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.27 out of 18.57
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 25.16 out of 36.53
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ZuR variant 1 | Zinc-responsive repressor

NZ_JAHPZL010000004.1 - Region 1 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 326,570 - 349,272 nt. (total: 22,703 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: cyclase
KEM60_RS07370: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000503.5 |  | 0.52 | ribosomal | cinnamycin | Streptomyces cinnamoneus
BGC0000528.5 |  | 0.51 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0002346.3 |  | 0.44 | ribosomal | kyamicin | Saccharopolyspora sp.
BGC0000516.4 |  | 0.44 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0001210.5 |  | 0.44 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0002110.3 |  | 0.44 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0000527.5 |  | 0.44 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0002700.2 |  | 0.43 | ribosomal | bacinapeptin | Bacillus nakamurai
BGC0002306.2 |  | 0.43 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000504.5 |  | 0.43 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000503.5 |  | 0.52 | ribosomal | cinnamycin | Streptomyces cinnamoneus
BGC0000528.5 |  | 0.51 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0002346.3 |  | 0.44 | ribosomal | kyamicin | Saccharopolyspora sp.
BGC0000516.4 |  | 0.44 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0001210.5 |  | 0.44 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0002110.3 |  | 0.44 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0000527.5 |  | 0.44 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0002700.2 |  | 0.43 | ribosomal | bacinapeptin | Bacillus nakamurai
BGC0002306.2 |  | 0.43 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000504.5 |  | 0.43 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for KEM60_RS07370

allorf_329221_329397
Leader:
MSCRGRQHPSRGA
Core:
W A L W G I P G E G R K F T F R G Q H L E P D R T Q V R R P A S S G C V Y L S G L T S P T
Core with dehydrations:
W A L W G I P G E G R K F Dhb F R G Q H L E P D R Dhb Q V R R P A Dha Dha G Cys V Y L Dha G L Dhb Dha P Dhb

#### antiSMASH-DB 4.0 matches for allorf_329221_329397

100.0%
NZ_JAHPZL010000004.1:
Lanthipeptides: allorf_329221_329397_lanthipeptide
1
W A L W G I P G E G R K F T F R G Q H L E P D R T Q V R R P A S S G C V Y L S G L T S P T
45
W A L W G I P G E G R K F T F R G Q H L E P D R T Q V R R P A S S G C V Y L S G L T S P T
1
W A L W G I P G E G R K F T F R G Q H L E P D R T Q V R R P A S S G C V Y L S G L T S P T
45
15.6%
NZ_JANVAG010000003.1:
Lanthipeptides: allorf_436904_437122_lanthipeptide
33
S G C V Y L S G L T S P T
45
S G C V+ S +T P+
2
S G C V F E S A I T D P S
14
allorf_329919_330011
Leader:
MWQDRRSGSFGG
Core:
S V C R R R V A G G P D A D P A V T
Core with dehydrations:
Dha V Cys R R R V A G G P D A D P A V Dhb

#### antiSMASH-DB 4.0 matches for allorf_329919_330011

100.0%
NZ_JAHPZL010000004.1:
Lanthipeptides: allorf_329919_330011_lanthipeptide
1
S V C R R R V A G G P D A D P A V T
18
S V C R R R V A G G P D A D P A V T
1
S V C R R R V A G G P D A D P A V T
18
35.0%
NZ_BMTW01000001.1:
Lanthipeptides: allorf_0729166_0729378_lanthipeptide
4
R R R V A G G P D A D
14
R R G P D A D
9
R R H R T G W P D A D
19
35.0%
NZ_CP067395.1:
Lanthipeptides: allorf_0865489_0865689_lanthipeptide
4
R R R V A G G P D A D P
15
R R R V+ P A P
5
R R R V S A H P R A Q P
16
with 2 more sequence matches
33.3%
NZ_CP010836.1:
Lassopeptides: TS85_RS25615_lassopeptide
7
V A G G P D A D
14
+ G G P D A D
3
I V G G P D A D
10
32.0%
NZ_CP050504.1:
Lanthipeptides: allorf_8941092_8941208_lanthipeptide
2
V C R R R V A G G P D
12
V C R R A G G D
4
V C R R G R A G G A D
14

#### MIBiG 4.0 matches for allorf_329919_330011

13.5%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
14
D P A V T
18
D P A V T
2
D P A V T
6
allorf_329924_330103
Leader:
MTGFLVRQGRDRKSGFGA
Core:
A S G S F S S V A S V N G C G R I G D Q D L L A D Q C V V G V S R A A L M P I L P
Core with dehydrations:
A Dha G Dha F Dha Dha V A Dha V N G Cys G R I G D Q D L L A D Q Cys V V G V Dha R A A L M P I L P

#### antiSMASH-DB 4.0 matches for allorf_329924_330103

100.0%
NZ_JAHPZL010000004.1:
Lanthipeptides: allorf_329924_330103_lanthipeptide
1
A S G S F S S V A S V N G C G R I G D Q D L L A D Q C V V G V S R A A L M P I L P
41
A S G S F S S V A S V N G C G R I G D Q D L L A D Q C V V G V S R A A L M P I L P
1
A S G S F S S V A S V N G C G R I G D Q D L L A D Q C V V G V S R A A L M P I L P
41
allorf_329941_330090
Leader:
MCVKAETGRVASELRAGVFHLWRLLTGVAGS
Core:
A I R I F W R I S V S S A C R G R P
Core with dehydrations:
A I R I F W R I Dha V Dha Dha A Cys R G R P

#### antiSMASH-DB 4.0 matches for allorf_329941_330090

100.0%
NZ_JAHPZL010000004.1:
Lanthipeptides: allorf_329941_330090_lanthipeptide
1
A I R I F W R I S V S S A C R G R P
18
A I R I F W R I S V S S A C R G R P
1
A I R I F W R I S V S S A C R G R P
18
20.8%
NZ_JAAXRC010000001.1:
Lanthipeptides: HFO56_RS03105_lanthipeptide
1
A I R I F W R I S V S S A C R G R
17
A+ + W S +S C
4
A L G L M W D A S C A S T C D S N
20
20.0%
NZ_SLWS01000023.1:
Lanthipeptides: allorf_57815_57919_lanthipeptide
3
R I F W R I S V S S A C R
15
R +W R+ C R
3
R S Y W R V R F D G N C R
15
allorf_330105_330254
Leader:
MSHSAGDVSDDCPISPYHDGAIAGH
Core:
R G R W G S P V P R D P N R T H D D C G M L L R
Core with dehydrations:
R G R W G Dha P V P R D P N R Dhb H D D Cys G M L L R

#### antiSMASH-DB 4.0 matches for allorf_330105_330254

100.0%
NZ_JAHPZL010000004.1:
Lanthipeptides: allorf_330105_330254_lanthipeptide
1
R G R W G S P V P R D P N R T H D D C G M L L R
24
R G R W G S P V P R D P N R T H D D C G M L L R
1
R G R W G S P V P R D P N R T H D D C G M L L R
24
27.3%
NZ_JAHUVY010000001.1 and 1 other:
NZ_JAHUVY010000001.1 Lanthipeptides: allorf_0075041_0075244_lanthipeptide
Lanthipeptides: allorf_0075041_0075244_lanthipeptide
2
G R W G S P V P-----R D P N R T H D D C G M L L R
24
G R G P P R P R H G M +R
5
G R D G P P S P P C G W A R T P P R G H S G T G M P V R
32
23.1%
NZ_JACJHX010000002.1:
Lassopeptides: HNP81_RS04455_lassopeptide
5
G S P V P R D P N
13
G S P+P D N
11
G S P I P V D E N
19
with 2 more sequence matches
20.8%
NZ_PGGW01000010.1 and 1 other:
NZ_PGGW01000010.1 Lanthipeptides: CUT44_RS02535_lanthipeptide
Lanthipeptides: CUT44_RS02535_lanthipeptide
13
N R T H D D C G
20
N+T D+C G
3
N K T S D N C G
10
16.7%
NZ_OCTY01000002.1:
Lanthipeptides: allorf_0873960_0874184_lanthipeptide
4
W G S P V P R D P N R
14
+ S P P R D P R
24
Y T S P R P R D P T R
34

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 23.38 out of 29.72
Confidence: medium
Additional weak hits (4):
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.32 out of 21.55
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 19.91 out of 29.25
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 19.72 out of 36.54
Confidence: weak
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.21 out of 26.33
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

allorf_329221_329397 - Class II
  Cleavage pHMM score: -5.10
  RODEO score: 0
  Monoisotopic mass: 4869.6 Da
  Molecular weight: 4872.5 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4890.5 Da N = 1
    4908.5 Da N = 2
    4926.5 Da N = 3
    4944.5 Da N = 4
    4962.6 Da N = 5
    4980.6 Da N = 6
    4998.6 Da N = 7
allorf_329919_330011 - Class II
  Cleavage pHMM score: -2.70
  RODEO score: 0
  Monoisotopic mass: 1789.9 Da
  Molecular weight: 1791.0 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1809.0 Da N = 1
allorf_329924_330103 - Class II
  Cleavage pHMM score: -6.40
  RODEO score: 0
  Monoisotopic mass: 3952.0 Da
  Molecular weight: 3954.5 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3972.5 Da N = 1
    3990.5 Da N = 2
    4008.5 Da N = 3
    4026.6 Da N = 4
allorf_329941_330090 - Class II
  Cleavage pHMM score: -5.30
  RODEO score: 0
  Monoisotopic mass: 2020.1 Da
  Molecular weight: 2021.4 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2039.4 Da N = 1
    2057.4 Da N = 2
allorf_330105_330254 - Class II
  Cleavage pHMM score: -6.80
  RODEO score: 0
  Monoisotopic mass: 2754.4 Da
  Molecular weight: 2756.1 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2774.1 Da N = 1

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
NtrC | Nitrogen regulatory protein C

NZ_JAHPZL010000007.1 - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 16,628 - 28,025 nt. (total: 11,398 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002115.3 |  | 0.55 | ribosomal | streptamidine | Streptomyces albidoflavus J1074
BGC0000513.3 |  | 0.50 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0001638.4 |  | 0.50 | ribosomal | klebsazolicin | Klebsiella pneumoniae subsp. ozaenae
BGC0002698.2 |  | 0.47 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0002306.2 |  | 0.43 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000558.5 |  | 0.42 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000551.5 |  | 0.42 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0001555.4 |  | 0.42 | ribosomal | colicin V | Escherichia coli chi7122
BGC0000519.4 |  | 0.41 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000590.5 |  | 0.41 | ribosomal | microcin N | Escherichia coli

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002115.3 |  | 0.55 | ribosomal | streptamidine | Streptomyces albidoflavus J1074
BGC0000513.3 |  | 0.50 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0001638.4 |  | 0.50 | ribosomal | klebsazolicin | Klebsiella pneumoniae subsp. ozaenae
BGC0002698.2 |  | 0.47 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0002306.2 |  | 0.43 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000558.5 |  | 0.42 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000551.5 |  | 0.42 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0001555.4 |  | 0.42 | ribosomal | colicin V | Escherichia coli chi7122
BGC0000519.4 |  | 0.41 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000590.5 |  | 0.41 | ribosomal | microcin N | Escherichia coli

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

NZ_JAHPZL010000008.1 - Region 1 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 130,800 - 151,885 nt. (total: 21,086 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Ligases: synthetase
KEM60_RS11235: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002309.2 |  | 0.38 | terpene | cattleyene | Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000677.5 |  | 0.34 | terpene | cyclooctatin | Streptomyces melanosporofaciens
BGC0000678.5 |  | 0.32 | terpene | pentalenolactone | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001456.3 |  | 0.31 | terpene | isorenieratene | Streptomyces argillaceus
BGC0001911.3 |  | 0.31 | terpene | raimonol | Streptomyces anulatus
BGC0001910.4 |  | 0.30 | terpene | cyslabdan A, cyslabdan B, cyslabdan C | Streptomyces cyslabdanicus
BGC0002294.3 |  | 0.29 | other (other) | streptozotocin | Streptomyces achromogenes subsp. streptozoticus
BGC0000665.5 |  | 0.28 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0000664.5 |  | 0.28 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001994.4 |  | 0.28 | other (other) | β-ethynylserine | Streptomyces cattleya NRRL 8057 = DSM 46488

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002309.2 |  | 0.38 | terpene | cattleyene | Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000677.5 |  | 0.34 | terpene | cyclooctatin | Streptomyces melanosporofaciens
BGC0000678.5 |  | 0.32 | terpene | pentalenolactone | Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0001456.3 |  | 0.31 | terpene | isorenieratene | Streptomyces argillaceus
BGC0001911.3 |  | 0.31 | terpene | raimonol | Streptomyces anulatus
BGC0001910.4 |  | 0.30 | terpene | cyslabdan A, cyslabdan B, cyslabdan C | Streptomyces cyslabdanicus
BGC0002294.3 |  | 0.29 | other (other) | streptozotocin | Streptomyces achromogenes subsp. streptozoticus
BGC0000665.5 |  | 0.28 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0000664.5 |  | 0.28 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001994.4 |  | 0.28 | other (other) | β-ethynylserine | Streptomyces cattleya NRRL 8057 = DSM 46488

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP
diterpene precursor |  | GGPP | C20 | acyclic | PP
sesterterpene precursor |  | GFPP | C25 | acyclic | PP
triterpene precursor |  | HPP | C30 | acyclic | PP

Genes with terpene domains:
KEM60_RS11235: PT_FPPS_like
Domain 1 (42 - 360): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: unknown

Reactions:
  IPP, DMAPP → FPP
  IPP, DMAPP → GGPP
  IPP, DMAPP → GFPP
  IPP, DMAPP → HPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 25.49 out of 29.65
Confidence: medium
Additional weak hits (3):
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 17.28 out of 27.78
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.31 out of 28.19
Confidence: weak
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 18.74 out of 24.78
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
GFPP | Geranylfarnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
HPP | Hexaprenyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
LexA variant 1 | Repressor of DNA damage response