GCF_016925535.1 - 15 region(s)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	lanthipeptide-class-i	1,403,330	1,428,445
Region 1.2	HR-T2PKS,butyrolactone	1,440,301	1,482,372
Region 1.3	T1PKS,NRPS	1,673,411	1,736,611
Region 1.4	NI-siderophore	1,828,352	1,859,389
Region 1.5	azole-containing-RiPP,NRPS	1,931,179	1,976,492	Low	triacsin C	other:other
Region 1.6	terpene-precursor	2,023,142	2,044,203
Region 1.7	NRP-metallophore,NRPS	2,118,529	2,167,955	Low	griseobactin	NRPS:Type I
Region 1.8	azole-containing-RiPP	2,261,264	2,287,564
Region 1.9	RiPP-like	2,383,327	2,397,344
Region 1.10	lanthipeptide-class-iii	2,422,036	2,444,801
Region 1.11	ectoine	2,891,641	2,902,069	High	ectoine	other:ectoine
Region 1.12	phosphonate	3,178,875	3,193,784
Region 1.13	NRPS-like	3,223,810	3,267,796
Region 1.14	hydrogen-cyanide	3,660,621	3,673,486	Low	aborycin	ribosomal:RiPP
Region 1.15	lanthipeptide-class-ii	3,764,510	3,787,851	High	SRO15-3108	ribosomal:RiPP:Lanthipeptide

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	lanthipeptide-class-i	1,403,330	1,428,445
Region 1.2	HR-T2PKS,butyrolactone	1,440,301	1,482,372
Region 1.3	T1PKS,NRPS	1,673,411	1,736,611
Region 1.4	NI-siderophore	1,828,352	1,859,389
Region 1.5	azole-containing-RiPP,NRPS	1,931,179	1,976,492	Low	triacsin C	other:other
Region 1.6	terpene-precursor	2,023,142	2,044,203
Region 1.7	NRP-metallophore,NRPS	2,118,529	2,167,955	Low	griseobactin	NRPS:Type I
Region 1.8	azole-containing-RiPP	2,261,264	2,287,564
Region 1.9	RiPP-like	2,383,327	2,397,344
Region 1.10	lanthipeptide-class-iii	2,422,036	2,444,801
Region 1.11	ectoine	2,891,641	2,902,069	High	ectoine	other:ectoine
Region 1.12	phosphonate	3,178,875	3,193,784
Region 1.13	NRPS-like	3,223,810	3,267,796
Region 1.14	hydrogen-cyanide	3,660,621	3,673,486	Low	aborycin	ribosomal:RiPP
Region 1.15	lanthipeptide-class-ii	3,764,510	3,787,851	High	SRO15-3108	ribosomal:RiPP:Lanthipeptide

NZ_CP070496.1 - Region 1 - lanthipeptide-class-i

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Location: 1,403,330 - 1,428,445 nt. (total: 25,116 nt) Show pHMM detection rules used

lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

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Reference	Similarity score	Type	Compound(s)	Organism
BGC0002576.2	0.75	ribosomal	mechercharmycin	Thermoactinomyces sp.
BGC0002640.2	0.56	ribosomal	thalassomonasin A, thalassomonasin B	Thalassomonas actiniarum
BGC0001289.5	0.49	ribosomal	penisin	Paenibacillus ehimensis
BGC0002316.2	0.44	ribosomal	cebulantin	Saccharopolyspora cebuensis
BGC0000541.5	0.44	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0002635.2	0.44	ribosomal	daspyromycin A, daspyromycin B	Actinokineospora diospyrosa
BGC0000542.3	0.44	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000544.4	0.40	ribosomal	planosporicin	Planomonospora alba
BGC0000506.4	0.39	ribosomal	entianin	Bacillus subtilis subsp. spizizenii
BGC0000511.5	0.37	ribosomal	ericin S	Bacillus subtilis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002576.2	0.75	ribosomal	mechercharmycin	Thermoactinomyces sp.
BGC0002640.2	0.56	ribosomal	thalassomonasin A, thalassomonasin B	Thalassomonas actiniarum
BGC0001289.5	0.49	ribosomal	penisin	Paenibacillus ehimensis
BGC0002316.2	0.44	ribosomal	cebulantin	Saccharopolyspora cebuensis
BGC0000541.5	0.44	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0002635.2	0.44	ribosomal	daspyromycin A, daspyromycin B	Actinokineospora diospyrosa
BGC0000542.3	0.44	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000544.4	0.40	ribosomal	planosporicin	Planomonospora alba
BGC0000506.4	0.39	ribosomal	entianin	Bacillus subtilis subsp. spizizenii
BGC0000511.5	0.37	ribosomal	ericin S	Bacillus subtilis

Regulator	Description
ANR	Anaerobic transcriptional regulator
VqsM	Regulator of quorum-sensing signalling systems

NZ_CP070496.1 - Region 2 - HR-T2PKS,butyrolactone

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Location: 1,440,301 - 1,482,372 nt. (total: 42,072 nt) Show pHMM detection rules used

HR-T2PKS: (hr-t2pks-ksa and (t2fas or APE_KS2 or ketoacyl-synt))
butyrolactone: AfsA

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Reference	Similarity score	Type	Compound(s)	Organism
BGC0001244.3	0.51	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0000231.5	0.32	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001197.5	0.30	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0002711.2	0.28	PKS	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0001987.2	0.27	PKS	koreenceine A, koreenceine B, koreenceine C, koreenceine D	Pseudomonas koreensis
BGC0002510.2	0.27	PKS	youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4	Streptomyces sp.
BGC0000204.5	0.27	PKS	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200
BGC0001810.3	0.27	PKS	trehangelin	Polymorphospora rubra
BGC0000188.5	0.26	other (other)	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0002554.2	0.25	other (other)	carquinostatin A, carquinostatin B	Streptomyces exfoliatus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001244.3	0.59	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0000231.5	0.47	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0002711.2	0.47	PKS	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0001197.5	0.46	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0001987.2	0.44	PKS	koreenceine A, koreenceine B, koreenceine C, koreenceine D	Pseudomonas koreensis
BGC0001810.3	0.44	PKS	trehangelin	Polymorphospora rubra
BGC0002510.2	0.44	PKS	youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4	Streptomyces sp.
BGC0000204.5	0.43	PKS	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200
BGC0002554.2	0.43	other (other)	carquinostatin A, carquinostatin B	Streptomyces exfoliatus
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842

Regulator	Description
CatR	H2O2-responsive repressor

NZ_CP070496.1 - Region 3 - NRPS,T1PKS

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Location: 1,673,411 - 1,736,611 nt. (total: 63,201 nt) Show pHMM detection rules used

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

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Reference	Similarity score	Type	Compound(s)	Organism
BGC0001758.4	0.63	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001833.4	0.62	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001273.3	0.59	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.58	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001240.4	0.58	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0000307.4	0.58	NRPS	AbT1	Aureobasidium pullulans
BGC0001160.5	0.58	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001166.5	0.58	NRPS	HC-toxin	Alternaria jesenskae
BGC0002191.2	0.58	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001249.5	0.58	NRPS	dimethylcoprogen	Alternaria alternata

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001758.4	0.65	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001833.4	0.64	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.63	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001240.4	0.63	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii
BGC0000307.4	0.63	NRPS	AbT1	Aureobasidium pullulans
BGC0001160.5	0.62	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001166.5	0.62	NRPS	HC-toxin	Alternaria jesenskae
BGC0002191.2	0.62	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001249.5	0.62	NRPS	dimethylcoprogen	Alternaria alternata

Regulator	Description
CcpA	Catabolite control protein A
DasR	N-acetylglucosamine dependent repressor
FuR variant 1	Ferric Uptake Regulator
RpoN	Regulator of nitrogen assimilation and virulence
RutR	Regulator of the pyrimidine and purine metabolism
VqsM	Regulator of quorum-sensing signalling systems
ZuR variant 1	Zinc-responsive repressor

NZ_CP070496.1 - Region 4 - NI-siderophore

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Location: 1,828,352 - 1,859,389 nt. (total: 31,038 nt) Show pHMM detection rules used

NI-siderophore: IucA_IucC

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Reference	Similarity score	Type	Compound(s)	Organism
BGC0002527.2	0.51	other (other)	vibrioferrin	Azotobacter vinelandii CA
BGC0001408.5	0.51	other (other)	xanthoferrin	Xanthomonas oryzae pv. oryzae KACC 10331
BGC0002692.2	0.49	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0001226.4	0.43	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0000563.4	0.42	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0001660.3	0.41	ribosomal	mathermycin	Marinactinospora thermotolerans
BGC0002635.2	0.41	ribosomal	daspyromycin A, daspyromycin B	Actinokineospora diospyrosa
BGC0001579.4	0.41	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0000541.5	0.40	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000503.5	0.40	ribosomal	cinnamycin	Streptomyces cinnamoneus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002527.2	0.51	other (other)	vibrioferrin	Azotobacter vinelandii CA
BGC0001408.5	0.51	other (other)	xanthoferrin	Xanthomonas oryzae pv. oryzae KACC 10331
BGC0002692.2	0.49	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0001226.4	0.43	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0000563.4	0.42	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0001660.3	0.41	ribosomal	mathermycin	Marinactinospora thermotolerans
BGC0002635.2	0.41	ribosomal	daspyromycin A, daspyromycin B	Actinokineospora diospyrosa
BGC0001579.4	0.41	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0000541.5	0.40	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000503.5	0.40	ribosomal	cinnamycin	Streptomyces cinnamoneus

Regulator	Description
NtrC	Nitrogen regulatory protein C
RpoN	Regulator of nitrogen assimilation and virulence

NZ_CP070496.1 - Region 5 - NRPS,azole-containing-RiPP

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Location: 1,931,179 - 1,976,492 nt. (total: 45,314 nt) Show pHMM detection rules used

azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

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Reference	Similarity score	Type	Compound(s)	Organism
BGC0001170.5	0.47	ribosomal	clostridiolysin S	Clostridium sporogenes ATCC 15579
BGC0000564.5	0.46	ribosomal	clostridiolysin S	Clostridium botulinum A str. ATCC 3502
BGC0000566.5	0.44	ribosomal	streptolysin S	Streptococcus pyogenes M1 GAS
BGC0001171.5	0.43	ribosomal	listeriolysin S	Listeria monocytogenes serotype 4b str. F2365
BGC0001825.4	0.30	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0002286.3	0.30	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.4	0.30	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.30	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001758.4	0.30	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001132.4	0.29	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001825.4	0.64	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0002286.3	0.64	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.4	0.64	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.63	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001758.4	0.63	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001132.4	0.63	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001135.5	0.63	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002135.2	0.62	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000357.5	0.62	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001261.3	0.62	NRPS	AM-toxin	Alternaria alternata

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
IolR	Regulator of the inositol catabolism
RpoN	Regulator of nitrogen assimilation and virulence

NZ_CP070496.1 - Region 6 - terpene-precursor

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Location: 2,023,142 - 2,044,203 nt. (total: 21,062 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

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Reference	Similarity score	Type	Compound(s)	Organism
BGC0001579.4	0.40	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0000677.5	0.39	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0002309.2	0.37	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000844.5	0.35	other (other)	clavulanic acid	Streptomyces clavuligerus
BGC0001911.3	0.35	terpene	raimonol	Streptomyces anulatus
BGC0001910.4	0.34	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0001550.3	0.33	ribosomal	citrulassin D	Streptomyces katrae
BGC0000664.5	0.32	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001227.3	0.32	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000678.5	0.31	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001579.4	0.40	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0000677.5	0.39	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0002309.2	0.37	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000844.5	0.35	other (other)	clavulanic acid	Streptomyces clavuligerus
BGC0001911.3	0.35	terpene	raimonol	Streptomyces anulatus
BGC0001910.4	0.34	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0001550.3	0.33	ribosomal	citrulassin D	Streptomyces katrae
BGC0000664.5	0.32	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001227.3	0.32	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000678.5	0.31	terpene	pentalenolactone	Streptomyces avermitilis MA-4680 = NBRC 14893

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

Regulator	Description
CcpA	Catabolite control protein A
DmdR1	Iron(II)-dependent repressor
MexT	Global virulence regulator

NZ_CP070496.1 - Region 7 - NRP-metallophore,NRPS

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Location: 2,118,529 - 2,167,955 nt. (total: 49,427 nt) Show pHMM detection rules used

NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

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Reference	Similarity score	Type	Compound(s)	Organism
BGC0000343.5	0.77	NRPS	enterobactin	Pseudomonas sp. J465
BGC0001135.5	0.61	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002164.2	0.59	NRPS	peramine	Epichloe festucae
BGC0002135.2	0.58	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002492.3	0.58	NRPS	myxochelin B, myxochelin A	Myxococcus xanthus DK 1622
BGC0001261.3	0.58	NRPS	AM-toxin	Alternaria alternata
BGC0001166.5	0.58	NRPS	HC-toxin	Alternaria jesenskae
BGC0001249.5	0.57	NRPS	dimethylcoprogen	Alternaria alternata
BGC0000357.5	0.57	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001185.5	0.56	NRPS	bacillibactin	Bacillus velezensis FZB42

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000343.5	0.71	NRPS	enterobactin	Pseudomonas sp. J465
BGC0001135.5	0.64	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002164.2	0.63	NRPS	peramine	Epichloe festucae
BGC0002135.2	0.63	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002492.3	0.63	NRPS	myxochelin B, myxochelin A	Myxococcus xanthus DK 1622
BGC0001261.3	0.63	NRPS	AM-toxin	Alternaria alternata
BGC0001166.5	0.62	NRPS	HC-toxin	Alternaria jesenskae
BGC0001249.5	0.62	NRPS	dimethylcoprogen	Alternaria alternata
BGC0000357.5	0.62	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255
BGC0001185.5	0.62	NRPS	bacillibactin	Bacillus velezensis FZB42

Regulator	Description
ANR	Anaerobic transcriptional regulator
ClgR	Caseinolytic protease gene regulator
DmdR1	Iron(II)-dependent repressor
PsrA	Oleic acid responsive regulator
RpoN	Regulator of nitrogen assimilation and virulence
VqsM	Regulator of quorum-sensing signalling systems

NZ_CP070496.1 - Region 8 - azole-containing-RiPP

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Location: 2,261,264 - 2,287,564 nt. (total: 26,301 nt) Show pHMM detection rules used

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Reference	Similarity score	Type	Compound(s)	Organism
BGC0000622.5	0.50	ribosomal	megacin	Bacillus megaterium
BGC0002584.2	0.47	ribosomal	azolemycin B, azolemycin A, azolemycin D, azolemycin C	Streptomyces sp. FXJ1.264
BGC0002311.3	0.44	ribosomal	cutimycin	Cutibacterium acnes KPA171202
BGC0002150.2	0.43	ribosomal	triculamin	Streptomyces triculaminicus
BGC0002151.2	0.43	ribosomal	alboverticillin	Streptomyces griseocarneus
BGC0000500.5	0.43	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0001167.4	0.42	ribosomal	piricyclamide 7005E1, piricyclamide 7005E2, piricyclamide 7005E3, piricyclamide 7005E4	Microcystis aeruginosa PCC 7005
BGC0000517.4	0.42	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0002551.2	0.39	other (other), ribosomal, terpene	muscoride A, muscoride B	Nostoc sp. UHCC-0398

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000622.5	0.50	ribosomal	megacin	Bacillus megaterium
BGC0002584.2	0.47	ribosomal	azolemycin B, azolemycin A, azolemycin D, azolemycin C	Streptomyces sp. FXJ1.264
BGC0002311.3	0.44	ribosomal	cutimycin	Cutibacterium acnes KPA171202
BGC0002150.2	0.43	ribosomal	triculamin	Streptomyces triculaminicus
BGC0002151.2	0.43	ribosomal	alboverticillin	Streptomyces griseocarneus
BGC0000500.5	0.43	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0001167.4	0.42	ribosomal	piricyclamide 7005E1, piricyclamide 7005E2, piricyclamide 7005E3, piricyclamide 7005E4	Microcystis aeruginosa PCC 7005
BGC0000517.4	0.42	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0002551.2	0.39	other (other), ribosomal, terpene	muscoride A, muscoride B	Nostoc sp. UHCC-0398

Regulator	Description
AbrC3	Antibiotic production activator
CRP	Cyclic AMP receptor protein
PsrA	Oleic acid responsive regulator

NZ_CP070496.1 - Region 9 - RiPP-like

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Location: 2,383,327 - 2,397,344 nt. (total: 14,018 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

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core biosynthetic genes

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Reference	Similarity score	Type	Compound(s)	Organism
BGC0002115.3	0.53	ribosomal	streptamidine	Streptomyces albidoflavus J1074
BGC0000519.4	0.49	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000571.3	0.42	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000558.5	0.42	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0001555.4	0.42	ribosomal	colicin V	Escherichia coli chi7122
BGC0000551.5	0.42	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0002312.2	0.42	ribosomal	ubonodin	Burkholderia ubonensis
BGC0001229.4	0.42	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000501.3	0.41	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002115.3	0.53	ribosomal	streptamidine	Streptomyces albidoflavus J1074
BGC0000519.4	0.49	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000571.3	0.42	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000558.5	0.42	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0001555.4	0.42	ribosomal	colicin V	Escherichia coli chi7122
BGC0000551.5	0.42	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0002312.2	0.42	ribosomal	ubonodin	Burkholderia ubonensis
BGC0001229.4	0.42	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000501.3	0.41	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928

Regulator	Description
FuR variant 1	Ferric Uptake Regulator
ZuR variant 1	Zinc-responsive repressor

NZ_CP070496.1 - Region 10 - lanthipeptide-class-iii

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Location: 2,422,036 - 2,444,801 nt. (total: 22,766 nt) Show pHMM detection rules used

lanthipeptide-class-iii: (micKC and not PKS_KS)

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Reference	Similarity score	Type	Compound(s)	Organism
BGC0001226.4	0.53	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0000551.5	0.52	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000496.5	0.51	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000519.4	0.51	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000919.5	0.44	other (other)	phaseolotoxin	Pseudomonas syringae
BGC0002701.2	0.44	ribosomal	paenithipeptin	Paenibacillus thiaminolyticus
BGC0002631.2	0.42	ribosomal	Myxarylin	Pyxidicoccus fallax
BGC0000503.5	0.41	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0002382.3	0.41	ribosomal	grimoviridin	Grimontia marina
BGC0000707.5	0.41	saccharide	kasugamycin	Streptomyces kasugaensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001226.4	0.53	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0000551.5	0.52	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000496.5	0.51	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000519.4	0.51	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000919.5	0.44	other (other)	phaseolotoxin	Pseudomonas syringae
BGC0002701.2	0.44	ribosomal	paenithipeptin	Paenibacillus thiaminolyticus
BGC0002631.2	0.42	ribosomal	Myxarylin	Pyxidicoccus fallax
BGC0000503.5	0.41	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0002382.3	0.41	ribosomal	grimoviridin	Grimontia marina
BGC0000707.5	0.41	saccharide	kasugamycin	Streptomyces kasugaensis

Regulator	Description
CcpA	Catabolite control protein A

NZ_CP070496.1 - Region 11 - ectoine

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Location: 2,891,641 - 2,902,069 nt. (total: 10,429 nt) Show pHMM detection rules used

ectoine: ectoine_synt

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Reference	Similarity score	Type	Compound(s)	Organism
BGC0002052.3	0.78	other (ectoine)	ectoine	Streptomyces sp.
BGC0000853.3	0.77	other (other)	ectoine	Streptomyces anulatus
BGC0000852.5	0.70	other (other)	ectoine	Sporosarcina pasteurii
BGC0000858.3	0.67	other (other)	ectoine	Methylobacter marinus
BGC0000856.3	0.66	other (other)	ectoine	Methylophaga thalassica
BGC0000860.3	0.59	other (other)	ectoine	Methylarcula marina
BGC0000857.3	0.59	other (other)	ectoine	Methylophaga alcalica
BGC0000854.3	0.57	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z
BGC0000855.3	0.55	other (other)	ectoine	Methylomicrobium kenyense
BGC0000859.3	0.55	other (other)	ectoine	Methylomicrobium alcaliphilum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002052.3	0.78	other (ectoine)	ectoine	Streptomyces sp.
BGC0000853.3	0.77	other (other)	ectoine	Streptomyces anulatus
BGC0000852.5	0.70	other (other)	ectoine	Sporosarcina pasteurii
BGC0000858.3	0.67	other (other)	ectoine	Methylobacter marinus
BGC0000856.3	0.66	other (other)	ectoine	Methylophaga thalassica
BGC0000860.3	0.59	other (other)	ectoine	Methylarcula marina
BGC0000857.3	0.59	other (other)	ectoine	Methylophaga alcalica
BGC0000854.3	0.57	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z
BGC0000855.3	0.55	other (other)	ectoine	Methylomicrobium kenyense
BGC0000859.3	0.55	other (other)	ectoine	Methylomicrobium alcaliphilum

Regulator	Description
CRP	Cyclic AMP receptor protein
CatR	H2O2-responsive repressor
HypR	L-hydroxyproline utilization repressor

NZ_CP070496.1 - Region 12 - phosphonate

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Location: 3,178,875 - 3,193,784 nt. (total: 14,910 nt) Show pHMM detection rules used

phosphonate: (phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase or phosphonatesMeIsocitrateLyase))

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Reference	Similarity score	Type	Compound(s)	Organism
BGC0000938.5	0.47	other (aminocoumarin)	fosfomycin	Streptomyces fradiae
BGC0000807.3	0.45	saccharide	phosphonoglycans	Stackebrandtia nassauensis DSM 44728
BGC0000897.5	0.43	other (other)	dehydrophos	Streptomyces luridus
BGC0002670.2	0.41	other (other)	fosfonochlorin	Fusarium oxysporum f. sp. lycopersici 4287
BGC0000806.5	0.38	saccharide	phosphonoglycans	Glycomyces sp. NRRL B-16210
BGC0000926.5	0.38	other (other)	rhizocticin A	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001739.3	0.35	other (other)	phosphonoacetic Acid	Streptomyces sp. NRRL F-525
BGC0001411.3	0.35	saccharide	polysaccharide B	Bacteroides fragilis
BGC0000937.5	0.32	other (other)	fosfazinomycin A, fosfazinomycin B	Streptomyces sp. WM6372
BGC0000753.3	0.28	saccharide	capsular polysaccharide	Actinobacillus pleuropneumoniae

NZ_CP070496.1 - Region 13 - NRPS-like

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Location: 3,223,810 - 3,267,796 nt. (total: 43,987 nt) Show pHMM detection rules used

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

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regulatory genes

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NZ_CP070496.1 - Region 14 - hydrogen-cyanide

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Location: 3,660,621 - 3,673,486 nt. (total: 12,866 nt) Show pHMM detection rules used

hydrogen-cyanide: (Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD) and DAO)

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core biosynthetic genes

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NZ_CP070496.1 - Region 15 - lanthipeptide-class-ii

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Location: 3,764,510 - 3,787,851 nt. (total: 23,342 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

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Reference	Similarity score	Type	Compound(s)	Organism
BGC0001633.3	0.43	other (other)	ketomemicin B3, ketomemicin B4	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0000577.3	0.37	ribosomal	sphingonodin II	Sphingobium japonicum UT26S
BGC0002285.2	0.35	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0001302.5	0.35	other (other)	lomofungin	Streptomyces lomondensis
BGC0001012.3	0.33	NRPS, PKS	meridamycin	Streptomyces violaceusniger
BGC0000813.3	0.32	other (other)	K-252a	Nonomuraea longicatena
BGC0000126.5	0.32	PKS	pladienolide B	Streptomyces platensis
BGC0002083.3	0.32	PKS	gladiofungin A, gladiofungin B	Burkholderia gladioli
BGC0001726.4	0.32	NRPS, PKS	pactamide A, pactamide B, pactamide C, pactamide D, pactamide E, pactamide F	Streptomyces pactum
BGC0000058.5	0.32	PKS	FD-891	Streptomyces graminofaciens

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001633.3	0.43	other (other)	ketomemicin B3, ketomemicin B4	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0000577.3	0.37	ribosomal	sphingonodin II	Sphingobium japonicum UT26S
BGC0002285.2	0.35	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0001302.5	0.35	other (other)	lomofungin	Streptomyces lomondensis
BGC0001012.3	0.33	NRPS, PKS	meridamycin	Streptomyces violaceusniger
BGC0000813.3	0.32	other (other)	K-252a	Nonomuraea longicatena
BGC0000126.5	0.32	PKS	pladienolide B	Streptomyces platensis
BGC0002083.3	0.32	PKS	gladiofungin A, gladiofungin B	Burkholderia gladioli
BGC0001726.4	0.32	NRPS, PKS	pactamide A, pactamide B, pactamide C, pactamide D, pactamide E, pactamide F	Streptomyces pactum
BGC0000058.5	0.32	PKS	FD-891	Streptomyces graminofaciens

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000554.4	0.70	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000626.3	0.56	ribosomal	thuricin	Bacillus thuringiensis
BGC0001555.4	0.52	ribosomal	colicin V	Escherichia coli chi7122
BGC0000516.4	0.52	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000590.5	0.51	ribosomal	microcin N	Escherichia coli
BGC0002005.2	0.51	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0000525.5	0.51	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0002698.2	0.50	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000528.5	0.50	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000588.5	0.49	ribosomal	microcin L	Escherichia coli

Identified secondary metabolite regions using strictness 'relaxed'

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Lanthipeptide(s) for JQS30_RS10325

antiSMASH-DB 4.0 matches for JQS30_RS10330

MIBiG 4.0 matches for JQS30_RS10330

antiSMASH-DB 4.0 matches for JQS30_RS10335

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Lanthipeptide(s) for JQS30_RS16105

antiSMASH-DB 4.0 matches for JQS30_RS16095

MIBiG 4.0 matches for JQS30_RS16095

antiSMASH-DB 4.0 matches for allorf_3767835_3767960

antiSMASH-DB 4.0 matches for allorf_3767860_3768009

antiSMASH-DB 4.0 matches for allorf_3770370_3770519

antiSMASH-DB 4.0 matches for allorf_3770845_3770946

antiSMASH-DB 4.0 matches for allorf_3773540_3773689

antiSMASH-DB 4.0 matches for allorf_3773571_3773729

MIBiG 4.0 matches for allorf_3773571_3773729

antiSMASH-DB 4.0 matches for allorf_3774399_3774488

antiSMASH-DB 4.0 matches for allorf_3783783_3783950

antiSMASH-DB 4.0 matches for allorf_3786763_3786897

antiSMASH-DB 4.0 matches for allorf_3786998_3787234

MIBiG 4.0 matches for allorf_3786998_3787234

antiSMASH-DB 4.0 matches for allorf_3787129_3787275

MIBiG 4.0 matches for allorf_3787129_3787275

antiSMASH-DB 4.0 matches for allorf_3787251_3787397

MIBiG 4.0 matches for allorf_3787251_3787397

antiSMASH-DB 4.0 matches for allorf_3787373_3787519

antiSMASH-DB 4.0 matches for allorf_3787427_3787648

MIBiG 4.0 matches for allorf_3787427_3787648

antiSMASH-DB 4.0 matches for allorf_3787434_3787580

antiSMASH-DB 4.0 matches for allorf_3787495_3787722

antiSMASH-DB 4.0 matches for allorf_3787556_3787777

antiSMASH-DB 4.0 matches for allorf_3787768_3787845

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