Select genomic region:
Overview
1.1
1.2
1.3
1.4
1.5
1.6
1.7
1.8
1.9
1.10
1.11
1.12
1.13
1.14
1.15

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP070496.1 (Natronoglycomyces albus)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | lanthipeptide-class-i | 1,403,330 | 1,428,445 |
Region 1.2 | HR-T2PKS,butyrolactone | 1,440,301 | 1,482,372 |
Region 1.3 | T1PKS,NRPS | 1,673,411 | 1,736,611 |
Region 1.4 | NI-siderophore | 1,828,352 | 1,859,389 |  |
Region 1.5 | azole-containing-RiPP,NRPS | 1,931,179 | 1,976,492 | Low | triacsin C | other:other
Region 1.6 | terpene-precursor | 2,023,142 | 2,044,203 |
Region 1.7 | NRP-metallophore,NRPS | 2,118,529 | 2,167,955 | Low | griseobactin | NRPS:Type I
Region 1.8 | azole-containing-RiPP | 2,261,264 | 2,287,564 |
Region 1.9 | RiPP-like | 2,383,327 | 2,397,344 |
Region 1.10 | lanthipeptide-class-iii | 2,422,036 | 2,444,801 |
Region 1.11 | ectoine | 2,891,641 | 2,902,069 | High | ectoine | other:ectoine
Region 1.12 | phosphonate | 3,178,875 | 3,193,784 |  |
Region 1.13 | NRPS-like | 3,223,810 | 3,267,796 |  |
Region 1.14 | hydrogen-cyanide | 3,660,621 | 3,673,486 | Low | aborycin | ribosomal:RiPP
Region 1.15 | lanthipeptide-class-ii | 3,764,510 | 3,787,851 | High | SRO15-3108 | ribosomal:RiPP:Lanthipeptide

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | lanthipeptide-class-i | 1,403,330 | 1,428,445 |
Region 1.2 | HR-T2PKS,butyrolactone | 1,440,301 | 1,482,372 |
Region 1.3 | T1PKS,NRPS | 1,673,411 | 1,736,611 |
Region 1.4 | NI-siderophore | 1,828,352 | 1,859,389 |  |
Region 1.5 | azole-containing-RiPP,NRPS | 1,931,179 | 1,976,492 | Low | triacsin C | other:other
Region 1.6 | terpene-precursor | 2,023,142 | 2,044,203 |
Region 1.7 | NRP-metallophore,NRPS | 2,118,529 | 2,167,955 | Low | griseobactin | NRPS:Type I
Region 1.8 | azole-containing-RiPP | 2,261,264 | 2,287,564 |
Region 1.9 | RiPP-like | 2,383,327 | 2,397,344 |
Region 1.10 | lanthipeptide-class-iii | 2,422,036 | 2,444,801 |
Region 1.11 | ectoine | 2,891,641 | 2,902,069 | High | ectoine | other:ectoine
Region 1.12 | phosphonate | 3,178,875 | 3,193,784 |  |
Region 1.13 | NRPS-like | 3,223,810 | 3,267,796 |  |
Region 1.14 | hydrogen-cyanide | 3,660,621 | 3,673,486 | Low | aborycin | ribosomal:RiPP
Region 1.15 | lanthipeptide-class-ii | 3,764,510 | 3,787,851 | High | SRO15-3108 | ribosomal:RiPP:Lanthipeptide

No secondary metabolite regions were found in these records:
  NZ_CP070498.1 (Natronoglycomyces albus)
  NZ_CP070497.1 (Natronoglycomyces albus)

Compact view
NZ_CP070496.1 - Region 1 - lanthipeptide-class-i
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,403,330 - 1,428,445 nt. (total: 25,116 nt) Show pHMM detection rules used
lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: cyclase dehydratase
JQS30_RS06005: Lantibiotic dehydratase domain protein

smcogs
  SMCOG1155: Lantibiotic dehydratase domain protein

JQS30_RS06010: Lanthionine synthetase C family protein

smcogs
  SMCOG1140: Lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-i | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002576.2 |  | 0.75 | ribosomal | mechercharmycin | Thermoactinomyces sp.
BGC0002640.2 |  | 0.56 | ribosomal | thalassomonasin A, thalassomonasin B | Thalassomonas actiniarum
BGC0001289.5 |  | 0.49 | ribosomal | penisin | Paenibacillus ehimensis
BGC0002316.2 |  | 0.44 | ribosomal | cebulantin | Saccharopolyspora cebuensis
BGC0000541.5 |  | 0.44 | ribosomal | paenicidin A | Paenibacillus polymyxa
BGC0002635.2 |  | 0.44 | ribosomal | daspyromycin A, daspyromycin B | Actinokineospora diospyrosa
BGC0000542.3 |  | 0.44 | ribosomal | paenicidin B | Paenibacillus terrae
BGC0000544.4 |  | 0.40 | ribosomal | planosporicin | Planomonospora alba
BGC0000506.4 |  | 0.39 | ribosomal | entianin | Bacillus subtilis subsp. spizizenii
BGC0000511.5 |  | 0.37 | ribosomal | ericin S | Bacillus subtilis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002576.2 |  | 0.75 | ribosomal | mechercharmycin | Thermoactinomyces sp.
BGC0002640.2 |  | 0.56 | ribosomal | thalassomonasin A, thalassomonasin B | Thalassomonas actiniarum
BGC0001289.5 |  | 0.49 | ribosomal | penisin | Paenibacillus ehimensis
BGC0002316.2 |  | 0.44 | ribosomal | cebulantin | Saccharopolyspora cebuensis
BGC0000541.5 |  | 0.44 | ribosomal | paenicidin A | Paenibacillus polymyxa
BGC0002635.2 |  | 0.44 | ribosomal | daspyromycin A, daspyromycin B | Actinokineospora diospyrosa
BGC0000542.3 |  | 0.44 | ribosomal | paenicidin B | Paenibacillus terrae
BGC0000544.4 |  | 0.40 | ribosomal | planosporicin | Planomonospora alba
BGC0000506.4 |  | 0.39 | ribosomal | entianin | Bacillus subtilis subsp. spizizenii
BGC0000511.5 |  | 0.37 | ribosomal | ericin S | Bacillus subtilis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.
Lanthipeptides - No core peptides found.
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.92 out of 20.47
Confidence: medium
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 22.38 out of 26.33
Confidence: medium
Additional weak hits (3):
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.01 out of 32.74
Confidence: weak
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.02 out of 26.85
Confidence: weak
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.44 out of 27.04
Confidence: weak
Lanthipeptides
RREFinder
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.
No core peptides found.
RRE predictions
RREfinder results sidepanel.

lanthipeptide-class-i protocluster (1403329...1428445)
JQS30_RS06005
  RRE type: Lanthipeptide_LanB_RRE
  Location: 134 - 224
  Score: 57.6

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
VqsM | Regulator of quorum-sensing signalling systems

NZ_CP070496.1 - Region 2 - HR-T2PKS,butyrolactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,440,301 - 1,482,372 nt. (total: 42,072 nt) Show pHMM detection rules used
HR-T2PKS: (hr-t2pks-ksa and (t2fas or APE_KS2 or ketoacyl-synt))
butyrolactone: AfsA

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
JQS30_RS06210: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Ligases: synthase
JQS30_RS06220: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

JQS30_RS06230: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs
  SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | HR-T2PKS | butyrolactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001244.3 |  |  | 0.51 | PKS | (-)-Mellein | Parastagonospora nodorum
BGC0000231.5 |  |  | 0.32 | PKS | griseusin A, griseusin B | Streptomyces griseus
BGC0001197.5 |  |  | 0.30 | PKS | frankiamicin | Frankia sp. EAN1pec
BGC0002711.2 |  |  | 0.28 | PKS | nostovalerolactone, 9-dehydronostovalerolactone | Nostoc punctiforme PCC 73102
BGC0001987.2 |  |  | 0.27 | PKS | koreenceine A, koreenceine B, koreenceine C, koreenceine D | Pseudomonas koreensis
BGC0002510.2 |  |  | 0.27 | PKS | youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4 | Streptomyces sp.
BGC0000204.5 |  |  | 0.27 | PKS | benastatin A, benastatin B, BE-43767, TAN1532B | Streptomyces sp. A2991200
BGC0001810.3 |  |  | 0.27 | PKS | trehangelin | Polymorphospora rubra
BGC0000188.5 |  |  | 0.26 | other (other) | saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2 | Cylindrospermopsis raciborskii T3
BGC0002554.2 |  |  | 0.25 | other (other) | carquinostatin A, carquinostatin B | Streptomyces exfoliatus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001244.3 |  | 0.59 | PKS | (-)-Mellein | Parastagonospora nodorum
BGC0000231.5 |  | 0.47 | PKS | griseusin A, griseusin B | Streptomyces griseus
BGC0002711.2 |  | 0.47 | PKS | nostovalerolactone, 9-dehydronostovalerolactone | Nostoc punctiforme PCC 73102
BGC0001197.5 |  | 0.46 | PKS | frankiamicin | Frankia sp. EAN1pec
BGC0001987.2 |  | 0.44 | PKS | koreenceine A, koreenceine B, koreenceine C, koreenceine D | Pseudomonas koreensis
BGC0001810.3 |  | 0.44 | PKS | trehangelin | Polymorphospora rubra
BGC0002510.2 |  | 0.44 | PKS | youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4 | Streptomyces sp.
BGC0000204.5 |  | 0.43 | PKS | benastatin A, benastatin B, BE-43767, TAN1532B | Streptomyces sp. A2991200
BGC0002554.2 |  | 0.43 | other (other) | carquinostatin A, carquinostatin B | Streptomyces exfoliatus
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 21.45 out of 25.31
Confidence: medium
Additional weak hits (11):
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.12 out of 32.74
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.96 out of 30.22
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.02 out of 27.78
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.29 out of 27.78
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.90 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 18.97 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.04 out of 26.06
Confidence: weak
BldD
Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.85 out of 23.43
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 20.13 out of 30.25
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 19.80 out of 31.73
Confidence: weak
DosR
Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 22.24 out of 29.51
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CatR | H2O2-responsive repressor

NZ_CP070496.1 - Region 3 - NRPS,T1PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,673,411 - 1,736,611 nt. (total: 63,201 nt) Show pHMM detection rules used
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: reductase
JQS30_RS07240: alkyl hydroperoxide reductase subunit

smcogs
  SMCOG1176: alkyl hydroperoxide reductase subunit

Hydrolases: back translocase
JQS30_RS07275: GTP-binding protein LepA

smcogs
  SMCOG1190: GTP-binding protein LepA

Ligases: ligase synthase
JQS30_RS07220: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

JQS30_RS07255: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

Translocases: transport
JQS30_RS07175: MMPL domain-containing transport protein

smcogs
  SMCOG1035: MMPL domain-containing transport protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T1PKS | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001758.4 |  |  | 0.63 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001833.4 |  |  | 0.62 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001273.3 |  |  | 0.59 | PKS | asperlactone | Aspergillus ochraceus
BGC0001244.3 |  |  | 0.58 | PKS | (-)-Mellein | Parastagonospora nodorum
BGC0001240.4 |  |  | 0.58 | NRPS | serinocyclin A, serinocyclin B | Metarhizium robertsii
BGC0000307.4 |  |  | 0.58 | NRPS | AbT1 | Aureobasidium pullulans
BGC0001160.5 |  |  | 0.58 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0001166.5 |  |  | 0.58 | NRPS | HC-toxin | Alternaria jesenskae
BGC0002191.2 |  |  | 0.58 | PKS | prolipyrone B, gibepyrone D | Fusarium graminearum PH-1
BGC0001249.5 |  |  | 0.58 | NRPS | dimethylcoprogen | Alternaria alternata

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001758.4 |  | 0.65 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001833.4 |  | 0.64 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001273.3 |  | 0.63 | PKS | asperlactone | Aspergillus ochraceus
BGC0001244.3 |  | 0.63 | PKS | (-)-Mellein | Parastagonospora nodorum
BGC0001240.4 |  | 0.63 | NRPS | serinocyclin A, serinocyclin B | Metarhizium robertsii
BGC0000307.4 |  | 0.63 | NRPS | AbT1 | Aureobasidium pullulans
BGC0001160.5 |  | 0.62 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0001166.5 |  | 0.62 | NRPS | HC-toxin | Alternaria jesenskae
BGC0002191.2 |  | 0.62 | PKS | prolipyrone B, gibepyrone D | Fusarium graminearum PH-1
BGC0001249.5 |  | 0.62 | NRPS | dimethylcoprogen | Alternaria alternata

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.18 out of 20.47
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 27.10 out of 29.38
Confidence: strong
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.22 out of 18.46
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.25 out of 20.97
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 27.11 out of 28.19
Confidence: strong
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 21.80 out of 27.04
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.68 out of 29.38
Confidence: medium
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.19 out of 26.85
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.53 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.13 out of 28.19
Confidence: medium
Additional weak hits (14):
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.62 out of 26.85
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 19.00 out of 27.78
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 19.50 out of 29.25
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.63 out of 29.38
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 18.35 out of 28.14
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 18.41 out of 28.14
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.77 out of 29.38
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 20.23 out of 29.38
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.93 out of 29.38
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.10 out of 27.78
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.59 out of 32.74
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 18.60 out of 33.14
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.75 out of 28.19
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.35 out of 30.98
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 4, location 1673410 - 1736611:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (ohmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 5, location 1673410 - 1721852:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (ohmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 6, location 1691097 - 1736611:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (ohmal)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
JQS30_RS07220: mal
PKS_AT (533..803): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 58.3%
  inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 110.6
  Methylmalonyl-CoA: 63.0
  Methoxymalonyl-CoA: 58.0
  inactive: 48.5
  Ethylmalonyl-CoA: 39.3
  Propionyl-CoA: 38.1
  Acetyl-CoA: 31.8
  Benzoyl-CoA: 23.9
  Isobutyryl-CoA: 23.7
  2-Methylbutyryl-CoA: 21.2
  fatty_acid: 15.8
  CHC-CoA: 12.9
  trans-1,2-CPDA: 12.3
  3-Methylbutyryl-CoA: 0.0

JQS30_RS07255: Cys
Search NORINE for peptide: strict or relaxed
AMP-binding (567..964): Cys
nrpys: Cys

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Small clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Single AA prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TDISFDLSVHDGNSMLSGDHSLGGATEASIWSIT
  Nearest Stachelhaus code(s):
    Cys DLYNMSLIWK (91% 8Å match)
  Stachelhaus code match:
    90% (moderate)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
DasR | N-acetylglucosamine dependent repressor
FuR variant 1 | Ferric Uptake Regulator
RpoN | Regulator of nitrogen assimilation and virulence
RutR | Regulator of the pyrimidine and purine metabolism
VqsM | Regulator of quorum-sensing signalling systems
ZuR variant 1 | Zinc-responsive repressor

NZ_CP070496.1 - Region 4 - NI-siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,828,352 - 1,859,389 nt. (total: 31,038 nt) Show pHMM detection rules used
NI-siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: glycosyltransferase
JQS30_RS07870: glycosyl transferase group 1

smcogs
  SMCOG1045: glycosyl transferase group 1

Lyases: decarboxylase
JQS30_RS07795: diaminopimelate decarboxylase

smcogs
  SMCOG1264: diaminopimelate decarboxylase

Ligases: synthase
JQS30_RS07735: polyprenol-monophosphomannose synthase ppm1

smcogs
  SMCOG1123: polyprenol-monophosphomannose synthase ppm1

JQS30_RS07740: polyprenol-monophosphomannose synthase ppm1

smcogs
  SMCOG1123: polyprenol-monophosphomannose synthase ppm1

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NI-siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002527.2 |  | 0.51 | other (other) | vibrioferrin | Azotobacter vinelandii CA
BGC0001408.5 |  | 0.51 | other (other) | xanthoferrin | Xanthomonas oryzae pv. oryzae KACC 10331
BGC0002692.2 |  | 0.49 | other (other) | speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B | Kribbella speibonae
BGC0001226.4 |  | 0.43 | ribosomal | streptocollin | Streptomyces collinus Tu 365
BGC0000563.4 |  | 0.42 | ribosomal | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0001660.3 |  | 0.41 | ribosomal | mathermycin | Marinactinospora thermotolerans
BGC0002635.2 |  | 0.41 | ribosomal | daspyromycin A, daspyromycin B | Actinokineospora diospyrosa
BGC0001579.4 |  | 0.41 | ribosomal | duramycin | Streptomyces cinnamoneus
BGC0000541.5 |  | 0.40 | ribosomal | paenicidin A | Paenibacillus polymyxa
BGC0000503.5 |  | 0.40 | ribosomal | cinnamycin | Streptomyces cinnamoneus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002527.2 |  | 0.51 | other (other) | vibrioferrin | Azotobacter vinelandii CA
BGC0001408.5 |  | 0.51 | other (other) | xanthoferrin | Xanthomonas oryzae pv. oryzae KACC 10331
BGC0002692.2 |  | 0.49 | other (other) | speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B | Kribbella speibonae
BGC0001226.4 |  | 0.43 | ribosomal | streptocollin | Streptomyces collinus Tu 365
BGC0000563.4 |  | 0.42 | ribosomal | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0001660.3 |  | 0.41 | ribosomal | mathermycin | Marinactinospora thermotolerans
BGC0002635.2 |  | 0.41 | ribosomal | daspyromycin A, daspyromycin B | Actinokineospora diospyrosa
BGC0001579.4 |  | 0.41 | ribosomal | duramycin | Streptomyces cinnamoneus
BGC0000541.5 |  | 0.40 | ribosomal | paenicidin A | Paenibacillus polymyxa
BGC0000503.5 |  | 0.40 | ribosomal | cinnamycin | Streptomyces cinnamoneus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 18.25 out of 18.46
Confidence: strong
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 23.81 out of 29.72
Confidence: medium
Additional weak hits (2):
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 24.02 out of 30.22
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.22 out of 30.22
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
NtrC | Nitrogen regulatory protein C
RpoN | Regulator of nitrogen assimilation and virulence

NZ_CP070496.1 - Region 5 - NRPS,azole-containing-RiPP
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,931,179 - 1,976,492 nt. (total: 45,314 nt) Show pHMM detection rules used
azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Azole RiPPs
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase oxygenase
JQS30_RS08230: aldo/keto reductase family oxidoreductase

smcogs
  SMCOG1039: aldo/keto reductase family oxidoreductase

JQS30_RS08330: FAD dependent oxidoreductase

smcogs
  SMCOG1103: FAD dependent oxidoreductase

JQS30_RS08335: lysine/ornithine N-monooxygenase

smcogs
  SMCOG1080: lysine/ornithine N-monooxygenase

JQS30_RS08350: cytochrome P450

smcogs
  SMCOG1007: cytochrome P450

JQS30_RS08355: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

Transferases: acetyltransferase
JQS30_RS08305: GCN5-related N-acetyltransferase

smcogs
  SMCOG1111: GCN5-related N-acetyltransferase

Hydrolases: esterase hydrolase
JQS30_RS08250: HAD-superfamily hydrolase, subfamily IA, variant

smcogs
  SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

JQS30_RS08375: thioesterase

smcogs
  SMCOG1004: thioesterase

Ligases: ligase synthase
JQS30_RS08315: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

JQS30_RS08320: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

JQS30_RS08365: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs
  SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

Translocases: permease
JQS30_RS08210: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | azole-containing-RiPP | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001170.5 |  |  | 0.47 | ribosomal | clostridiolysin S | Clostridium sporogenes ATCC 15579
BGC0000564.5 |  |  | 0.46 | ribosomal | clostridiolysin S | Clostridium botulinum A str. ATCC 3502
BGC0000566.5 |  |  | 0.44 | ribosomal | streptolysin S | Streptococcus pyogenes M1 GAS
BGC0001171.5 |  |  | 0.43 | ribosomal | listeriolysin S | Listeria monocytogenes serotype 4b str. F2365
BGC0001825.4 |  |  | 0.30 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0002286.3 |  |  | 0.30 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.4 |  |  | 0.30 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4 |  |  | 0.30 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001758.4 |  |  | 0.30 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001132.4 |  |  | 0.29 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001825.4 |  | 0.64 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0002286.3 |  | 0.64 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.4 |  | 0.64 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4 |  | 0.63 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001758.4 |  | 0.63 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001132.4 |  | 0.63 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001135.5 |  | 0.63 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0002135.2 |  | 0.62 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0000357.5 |  | 0.62 | NRPS | cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val) | Penicillium rubens Wisconsin 54-1255
BGC0001261.3 |  | 0.62 | NRPS | AM-toxin | Alternaria alternata

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 18.25 out of 18.46
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.16 out of 27.78
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.33 out of 23.79
Confidence: medium
Additional weak hits (5):
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.62 out of 39.62
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 18.54 out of 29.38
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.09 out of 30.98
Confidence: weak
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.31 out of 25.88
Confidence: weak
NrdR
Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 20.71 out of 27.18
Confidence: weak
(Thi)azol(in)e containing peptide predictions
Lists the possible core peptides for each biosynthetic enzyme. Predicted tail sequences are also shown, if present.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.
No core peptides found.
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
RREFinder
TFBS Finder
Azole RiPPs
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 8, location 1931178 - 1976492:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Cys)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 10, location 1933207 - 1976492:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Cys)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
JQS30_RS08315: X
AMP-binding (11..402): X
nrpys: (unknown)

SVM prediction details:
  Predicted physicochemical class:
    N/A
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    SAVL--LSLLQSMGWTGSAYEGYGLNETCIVSKN
  Nearest Stachelhaus code(s):
    Gly DLLMWCAITK (32% 8Å match)
  Stachelhaus code match:
    60% (weak)

JQS30_RS08320: Cys
Search NORINE for peptide: strict or relaxed
AMP-binding (517..911): Cys
nrpys: Cys

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Small clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Single AA prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:
  Stachelhaus sequence:
    VDCSFDLSVWDGNSMMSGDSSLGGPTETTIWNIT
  Nearest Stachelhaus code(s):
    Cys DLYNMSLIWK (74% 8Å match)
  Stachelhaus code match:
    90% (moderate)

Link to PARAS substrate predictor
RRE predictions
RREfinder results sidepanel.

azole-containing-RiPP protocluster (1931178...1954605)
JQS30_RS08260
  RRE type: Cytolysin_C_RRE
  Location: 9 - 97
  Score: 42.2

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
IolR | Regulator of the inositol catabolism
RpoN | Regulator of nitrogen assimilation and virulence

Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its possible molecular weights and the scores for cleavage site prediction and RODEO. If relevant, other features, such as macrocycle and amidation, will also be listed.
No core peptides found.
NZ_CP070496.1 - Region 6 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,023,142 - 2,044,203 nt. (total: 21,062 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Ligases: synthetase
JQS30_RS08655: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Translocases: transporter
JQS30_RS08620: sugar-binding lipoprotein

smcogs
  SMCOG1143: sugar-binding lipoprotein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001579.4 |  | 0.40 | ribosomal | duramycin | Streptomyces cinnamoneus
BGC0000677.5 |  | 0.39 | terpene | cyclooctatin | Streptomyces melanosporofaciens
BGC0002309.2 |  | 0.37 | terpene | cattleyene | Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000844.5 |  | 0.35 | other (other) | clavulanic acid | Streptomyces clavuligerus
BGC0001911.3 |  | 0.35 | terpene | raimonol | Streptomyces anulatus
BGC0001910.4 |  | 0.34 | terpene | cyslabdan A, cyslabdan B, cyslabdan C | Streptomyces cyslabdanicus
BGC0001550.3 |  | 0.33 | ribosomal | citrulassin D | Streptomyces katrae
BGC0000664.5 |  | 0.32 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001227.3 |  | 0.32 | terpene | isorenieratene | Streptomyces collinus Tu 365
BGC0000678.5 |  | 0.31 | terpene | pentalenolactone | Streptomyces avermitilis MA-4680 = NBRC 14893

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001579.4 |  | 0.40 | ribosomal | duramycin | Streptomyces cinnamoneus
BGC0000677.5 |  | 0.39 | terpene | cyclooctatin | Streptomyces melanosporofaciens
BGC0002309.2 |  | 0.37 | terpene | cattleyene | Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000844.5 |  | 0.35 | other (other) | clavulanic acid | Streptomyces clavuligerus
BGC0001911.3 |  | 0.35 | terpene | raimonol | Streptomyces anulatus
BGC0001910.4 |  | 0.34 | terpene | cyslabdan A, cyslabdan B, cyslabdan C | Streptomyces cyslabdanicus
BGC0001550.3 |  | 0.33 | ribosomal | citrulassin D | Streptomyces katrae
BGC0000664.5 |  | 0.32 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001227.3 |  | 0.32 | terpene | isorenieratene | Streptomyces collinus Tu 365
BGC0000678.5 |  | 0.31 | terpene | pentalenolactone | Streptomyces avermitilis MA-4680 = NBRC 14893

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP
diterpene precursor |  | GGPP | C20 | acyclic | PP
sesterterpene precursor |  | GFPP | C25 | acyclic | PP
triterpene precursor |  | HPP | C30 | acyclic | PP

Genes with terpene domains:
JQS30_RS08655: PT_FPPS_like
Domain 1 (40 - 351): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: unknown

Reactions:
  IPP, DMAPP → FPP
  IPP, DMAPP → GGPP
  IPP, DMAPP → GFPP
  IPP, DMAPP → HPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.58 out of 21.84
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.20 out of 20.97
Confidence: medium
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 31.19 out of 36.53
Confidence: medium
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.58 out of 21.84
Confidence: medium
Additional weak hits (3):
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.58 out of 30.25
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 24.99 out of 36.53
Confidence: weak
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.12 out of 27.04
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
GFPP | Geranylfarnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
HPP | Hexaprenyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
DmdR1 | Iron(II)-dependent repressor
MexT | Global virulence regulator

NZ_CP070496.1 - Region 7 - NRP-metallophore,NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,118,529 - 2,167,955 nt. (total: 49,427 nt) Show pHMM detection rules used
NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
JQS30_RS09110: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: PPTase
JQS30_RS09140: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: hydrolase
JQS30_RS09095: isochorismatase

smcogs
  SMCOG1027: isochorismatase

Isomerases: isomerase
JQS30_RS09105: isochorismate synthase

smcogs
  SMCOG1018: isochorismate synthase

Ligases: ligase
JQS30_RS09085: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

JQS30_RS09100: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRP-metallophore | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000343.5 |  |  | 0.77 | NRPS | enterobactin | Pseudomonas sp. J465
BGC0001135.5 |  |  | 0.61 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0002164.2 |  |  | 0.59 | NRPS | peramine | Epichloe festucae
BGC0002135.2 |  |  | 0.58 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0002492.3 |  |  | 0.58 | NRPS | myxochelin B, myxochelin A | Myxococcus xanthus DK 1622
BGC0001261.3 |  |  | 0.58 | NRPS | AM-toxin | Alternaria alternata
BGC0001166.5 |  |  | 0.58 | NRPS | HC-toxin | Alternaria jesenskae
BGC0001249.5 |  |  | 0.57 | NRPS | dimethylcoprogen | Alternaria alternata
BGC0000357.5 |  |  | 0.57 | NRPS | cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val) | Penicillium rubens Wisconsin 54-1255
BGC0001185.5 |  |  | 0.56 | NRPS | bacillibactin | Bacillus velezensis FZB42

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000343.5 |  | 0.71 | NRPS | enterobactin | Pseudomonas sp. J465
BGC0001135.5 |  | 0.64 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0002164.2 |  | 0.63 | NRPS | peramine | Epichloe festucae
BGC0002135.2 |  | 0.63 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0002492.3 |  | 0.63 | NRPS | myxochelin B, myxochelin A | Myxococcus xanthus DK 1622
BGC0001261.3 |  | 0.63 | NRPS | AM-toxin | Alternaria alternata
BGC0001166.5 |  | 0.62 | NRPS | HC-toxin | Alternaria jesenskae
BGC0001249.5 |  | 0.62 | NRPS | dimethylcoprogen | Alternaria alternata
BGC0000357.5 |  | 0.62 | NRPS | cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val) | Penicillium rubens Wisconsin 54-1255
BGC0001185.5 |  | 0.62 | NRPS | bacillibactin | Bacillus velezensis FZB42

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.54 out of 26.33
Confidence: medium
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 25.48 out of 30.22
Confidence: medium
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.82 out of 18.46
Confidence: medium
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.25 out of 20.47
Confidence: medium
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 34.36 out of 36.53
Confidence: strong
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 31.03 out of 36.53
Confidence: medium
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.92 out of 25.88
Confidence: medium
Additional weak hits (15):
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 22.94 out of 30.97
Confidence: weak
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.46 out of 25.75
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.63 out of 21.55
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.25 out of 30.22
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 20.42 out of 33.73
Confidence: weak
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 19.07 out of 24.78
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 20.97 out of 35.63
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 23.29 out of 36.53
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 19.36 out of 29.25
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.72 out of 28.19
Confidence: weak
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 19.03 out of 24.78
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 23.23 out of 36.53
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.40 out of 36.53
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 20.09 out of 29.38
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.65 out of 29.65
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 12, location 2118528 - 2167955:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Lys)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
JQS30_RS09085: Lys
Search NORINE for peptide: strict or relaxed
AMP-binding (440..799): Lys
nrpys: Lys

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    FSAAFDAHVEEVDLIIGGEINTYGPTEATVVCVA
  Nearest Stachelhaus code(s):
    Lys DAEDIGTVVK (79% 8Å match)
  Stachelhaus code match:
    100% (strong)

JQS30_RS09100: diOH-Bz
Search NORINE for peptide: strict or relaxed
AMP-binding (31..424): diOH-Bz
nrpys: diOH-Bz

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Small clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Single AA prediction:
    dhb (diOH-Bz)

Stachelhaus prediction details:
  Stachelhaus sequence:
    SAALFPLSSPGGSAQVGGAQQVFGMAEGLVCYTR
  Nearest Stachelhaus code(s):
    diOH-Bz PLPSQGVVNK (88% 8Å match)
    n-oh-nitropheBut TLPSQGVVCK (82% 8Å match)
  Stachelhaus code match:
    90% (moderate)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
ClgR | Caseinolytic protease gene regulator
DmdR1 | Iron(II)-dependent repressor
PsrA | Oleic acid responsive regulator
RpoN | Regulator of nitrogen assimilation and virulence
VqsM | Regulator of quorum-sensing signalling systems

NZ_CP070496.1 - Region 8 - azole-containing-RiPP
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,261,264 - 2,287,564 nt. (total: 26,301 nt) Show pHMM detection rules used
azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Azole RiPPs
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: protease
JQS30_RS09615: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | azole-containing-RiPP | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000622.5 |  | 0.50 | ribosomal | megacin | Bacillus megaterium
BGC0002584.2 |  | 0.47 | ribosomal | azolemycin B, azolemycin A, azolemycin D, azolemycin C | Streptomyces sp. FXJ1.264
BGC0002311.3 |  | 0.44 | ribosomal | cutimycin | Cutibacterium acnes KPA171202
BGC0002150.2 |  | 0.43 | ribosomal | triculamin | Streptomyces triculaminicus
BGC0002151.2 |  | 0.43 | ribosomal | alboverticillin | Streptomyces griseocarneus
BGC0000500.5 |  | 0.43 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0001167.4 |  | 0.42 | ribosomal | piricyclamide 7005E1, piricyclamide 7005E2, piricyclamide 7005E3, piricyclamide 7005E4 | Microcystis aeruginosa PCC 7005
BGC0000517.4 |  | 0.42 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0002551.2 |  | 0.39 | other (other), ribosomal, terpene | muscoride A, muscoride B | Nostoc sp. UHCC-0398

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000622.5 |  | 0.50 | ribosomal | megacin | Bacillus megaterium
BGC0002584.2 |  | 0.47 | ribosomal | azolemycin B, azolemycin A, azolemycin D, azolemycin C | Streptomyces sp. FXJ1.264
BGC0002311.3 |  | 0.44 | ribosomal | cutimycin | Cutibacterium acnes KPA171202
BGC0002150.2 |  | 0.43 | ribosomal | triculamin | Streptomyces triculaminicus
BGC0002151.2 |  | 0.43 | ribosomal | alboverticillin | Streptomyces griseocarneus
BGC0000500.5 |  | 0.43 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0001167.4 |  | 0.42 | ribosomal | piricyclamide 7005E1, piricyclamide 7005E2, piricyclamide 7005E3, piricyclamide 7005E4 | Microcystis aeruginosa PCC 7005
BGC0000517.4 |  | 0.42 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0002551.2 |  | 0.39 | other (other), ribosomal, terpene | muscoride A, muscoride B | Nostoc sp. UHCC-0398

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.80 out of 18.16
Confidence: strong
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 22.33 out of 25.88
Confidence: medium
Additional weak hits (13):
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.82 out of 26.85
Confidence: weak
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.08 out of 25.88
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.50 out of 30.22
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 20.59 out of 30.97
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.78 out of 21.55
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.40 out of 27.78
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.17 out of 39.62
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 17.12 out of 28.14
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.36 out of 27.78
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.23 out of 30.98
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.23 out of 30.98
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.94 out of 20.01
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.08 out of 28.19
Confidence: weak
(Thi)azol(in)e containing peptide predictions
Lists the possible core peptides for each biosynthetic enzyme. Predicted tail sequences are also shown, if present.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.
No core peptides found.
TFBS Finder
Azole RiPPs
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CRP | Cyclic AMP receptor protein
PsrA | Oleic acid responsive regulator

Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its possible molecular weights and the scores for cleavage site prediction and RODEO. If relevant, other features, such as macrocycle and amidation, will also be listed.
No core peptides found.
NZ_CP070496.1 - Region 9 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,383,327 - 2,397,344 nt. (total: 14,018 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: dehydratase
JQS30_RS10130: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002115.3 |  | 0.53 | ribosomal | streptamidine | Streptomyces albidoflavus J1074
BGC0000519.4 |  | 0.49 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000571.3 |  | 0.42 | ribosomal | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000558.5 |  | 0.42 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0001555.4 |  | 0.42 | ribosomal | colicin V | Escherichia coli chi7122
BGC0000551.5 |  | 0.42 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0002312.2 |  | 0.42 | ribosomal | ubonodin | Burkholderia ubonensis
BGC0001229.4 |  | 0.42 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000501.3 |  | 0.41 | ribosomal | catenulipeptin | Catenulispora acidiphila DSM 44928

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002115.3 |  | 0.53 | ribosomal | streptamidine | Streptomyces albidoflavus J1074
BGC0000519.4 |  | 0.49 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000571.3 |  | 0.42 | ribosomal | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000558.5 |  | 0.42 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0001555.4 |  | 0.42 | ribosomal | colicin V | Escherichia coli chi7122
BGC0000551.5 |  | 0.42 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0002312.2 |  | 0.42 | ribosomal | ubonodin | Burkholderia ubonensis
BGC0001229.4 |  | 0.42 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000501.3 |  | 0.41 | ribosomal | catenulipeptin | Catenulispora acidiphila DSM 44928

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.87 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.41 out of 29.38
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 26.44 out of 28.19
Confidence: strong
Additional weak hits (5):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.57 out of 29.38
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.87 out of 29.38
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.82 out of 32.74
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 20.95 out of 35.63
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.72 out of 28.19
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
FuR variant 1 | Ferric Uptake Regulator
ZuR variant 1 | Zinc-responsive repressor

NZ_CP070496.1 - Region 10 - lanthipeptide-class-iii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,422,036 - 2,444,801 nt. (total: 22,766 nt) Show pHMM detection rules used
lanthipeptide-class-iii: (micKC and not PKS_KS)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: reductase
JQS30_RS10355: alkyl hydroperoxide reductase/ Thiol specific

smcogs
  SMCOG1196: alkyl hydroperoxide reductase/ Thiol specific

Transferases: aminotransferase methyltransferase
JQS30_RS10295: methyltransferase

smcogs
  SMCOG1248: methyltransferase

JQS30_RS10300: methyltransferase

smcogs
  SMCOG1248: methyltransferase

JQS30_RS10310: aminotransferase class-III

smcogs
  SMCOG1013: aminotransferase class-III

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-iii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001226.4 |  | 0.53 | ribosomal | streptocollin | Streptomyces collinus Tu 365
BGC0000551.5 |  | 0.52 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000496.5 |  | 0.51 | ribosomal | AmfS | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000519.4 |  | 0.51 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000919.5 |  | 0.44 | other (other) | phaseolotoxin | Pseudomonas syringae
BGC0002701.2 |  | 0.44 | ribosomal | paenithipeptin | Paenibacillus thiaminolyticus
BGC0002631.2 |  | 0.42 | ribosomal | Myxarylin | Pyxidicoccus fallax
BGC0000503.5 |  | 0.41 | ribosomal | cinnamycin | Streptomyces cinnamoneus
BGC0002382.3 |  | 0.41 | ribosomal | grimoviridin | Grimontia marina
BGC0000707.5 |  | 0.41 | saccharide | kasugamycin | Streptomyces kasugaensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001226.4 |  | 0.53 | ribosomal | streptocollin | Streptomyces collinus Tu 365
BGC0000551.5 |  | 0.52 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000496.5 |  | 0.51 | ribosomal | AmfS | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000519.4 |  | 0.51 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000919.5 |  | 0.44 | other (other) | phaseolotoxin | Pseudomonas syringae
BGC0002701.2 |  | 0.44 | ribosomal | paenithipeptin | Paenibacillus thiaminolyticus
BGC0002631.2 |  | 0.42 | ribosomal | Myxarylin | Pyxidicoccus fallax
BGC0000503.5 |  | 0.41 | ribosomal | cinnamycin | Streptomyces cinnamoneus
BGC0002382.3 |  | 0.41 | ribosomal | grimoviridin | Grimontia marina
BGC0000707.5 |  | 0.41 | saccharide | kasugamycin | Streptomyces kasugaensis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for JQS30_RS10325

JQS30_RS10330
Leader:
MKKILNLQKMPSAATRSSID
Core:
A I S W S S C D S D S C N K A V Q
Core with dehydrations:
A I Dha W Dha Dha Cys D Dha D Dha Cys N K A V Q

#### antiSMASH-DB 4.0 matches for JQS30_RS10330

100.0%
NZ_CP070496.1:
Lanthipeptides: JQS30_RS10330_lanthipeptide
1
A I S W S S C D S D S C N K A V Q
17
A I S W S S C D S D S C N K A V Q
1
A I S W S S C D S D S C N K A V Q
17
72.2%
NZ_CP070496.1:
Lanthipeptides: JQS30_RS10335_lanthipeptide
1
A I S W S S C D S D S C N K A V
16
A I S W S S C D S S C N V
1
A I S W S S C D S G S C N G Q V
16
58.8%
NZ_KE384306.1:
Lanthipeptides: allorf_0853037_0853141_lanthipeptide
1
A I S W S S C D S D S C
12
A I S S S C D S S C
3
A I S I S S C D S Q S C
14
with 16 more sequence matches
Only the first 10 are displayed here.
58.8%
NZ_NNBO01000009.1 and 3 others:
NZ_NNBO01000009.1 Lanthipeptides: allorf_118429_118530_lanthipeptide NZ_NNBO01000009.1 Lanthipeptides: allorf_118429_118530_lanthipeptide NZ_NNBO01000009.1 Lanthipeptides: allorf_118429_118530_lanthipeptide
Lanthipeptides: allorf_118429_118530_lanthipeptide
1
A I S W S S C D S D S C
12
A I S S S C D S S C
6
A I S V S S C D S H S C
17
52.9%
NZ_CP085710.1:
Lanthipeptides: allorf_3217696_3217818_lanthipeptide
1
A I S W S S C D S D S C N K A V Q
17
+S +S C D S S C N K +
1
P V S C T S C D S Y S C N K K P E
17
50.0%
NZ_LISX01000002.1 and 3 others:
NZ_LISX01000002.1 Lanthipeptides: allorf_740642_740746_lanthipeptide NZ_LISX01000002.1 Lanthipeptides: allorf_740642_740746_lanthipeptide NZ_LISX01000002.1 Lanthipeptides: allorf_740642_740746_lanthipeptide
Lanthipeptides: allorf_740642_740746_lanthipeptide
1
A I S W S S C D S D S C
12
A+S S S C D S S C
7
A V S L S S C D S H S C
18
36.8%
NZ_CP085710.1:
Lanthipeptides: allorf_3218746_3218883_lanthipeptide
3
S W S S C D S D S C N K A
15
S +S C S S C N+
6
S C T S C T S H S C N R P
18
35.0%
NZ_CP051301.1:
Lanthipeptides: E4O04_RS14070_lanthipeptide
3
S W S S C D S D S C N K A V
16
S W S C S C N +
1
S W G S C G H H S C N S G L
14
35.0%
NZ_CP051302.1 and 3 others:
NZ_CP054477.1 Lanthipeptides: allorf_2300462_2300590_lanthipeptide NZ_CP058347.1 Lanthipeptides: allorf_2346513_2346641_lanthipeptide NZ_CP109619.1 Lanthipeptides: OE909_RS11400_lanthipeptide
Lanthipeptides: allorf_2256144_2256272_lanthipeptide
3
S W S S C D S D S C N K A V
16
S W S C+ S C N +
1
S W G S C N H H S C N S G L
14
23.7%
NZ_LISX01000002.1 and 3 others:
NZ_LISX01000002.1 Lanthipeptides: allorf_740844_741005_lanthipeptide NZ_LISX01000002.1 Lanthipeptides: allorf_740844_741005_lanthipeptide NZ_LISX01000002.1 Lanthipeptides: allorf_740844_741005_lanthipeptide
Lanthipeptides: allorf_740844_741005_lanthipeptide
1
A I S W S S C D S D S C
12
+I S S S C D S S C
27
S I S V S S C D S H S C
38
22.7%
NZ_PUPX01000001.1:
Lanthipeptides: allorf_1093571_1093699_lanthipeptide
4
W S S C D S D S C N K
14
W+S D+D C +
2
W A S T D A D Q C A R
12
22.2%
NZ_CP034414.1 and 1 other:
NZ_CP034414.1 Lanthipeptides: EI692_RS18435_lanthipeptide
Lanthipeptides: EI692_RS18435_lanthipeptide
2
I S W S S C D S D S C N K A
15
I S ++C S +C +A
13
I S T N T C P S T A C T R A
26
22.2%
NZ_KQ948146.1:
Lanthipeptides: allorf_888774_889007_lanthipeptide
2
I S W S S C D S D S C N K A V Q
17
+S +S C S S C+ +
11
V S L T S C T S H S C H G V A E
26

#### MIBiG 4.0 matches for JQS30_RS10330

17.4%
BGC0002111.3 (EVG22_32245):
Lanthipeptide: andalusicin A or andalusicin B
3
S W S S C D S D S C
12
+W+S S++C
14
A W A S T I S N N C
23
17.4%
BGC0002111.3 (multiple genes):
Lanthipeptide: andalusicin A or andalusicin B
4
W S S C D S D S C
12
W+S S++C
15
W A S T I S N N C
23
JQS30_RS10335
Leader:
MKKILKLQKMPSAATRSSID
Core:
A I S W S S C D S G S C N G Q V I Q
Core with dehydrations:
A I Dha W Dha Dha Cys D Dha G Dha Cys N G Q V I Q

#### antiSMASH-DB 4.0 matches for JQS30_RS10335

100.0%
NZ_CP070496.1:
Lanthipeptides: JQS30_RS10335_lanthipeptide
1
A I S W S S C D S G S C N G Q V I Q
18
A I S W S S C D S G S C N G Q V I Q
1
A I S W S S C D S G S C N G Q V I Q
18
55.6%
NZ_KE384306.1:
Lanthipeptides: allorf_0853037_0853141_lanthipeptide
1
A I S W S S C D S G S C
12
A I S S S C D S S C
3
A I S I S S C D S Q S C
14
55.6%
NZ_NNBO01000009.1 and 3 others:
NZ_NNBO01000009.1 Lanthipeptides: allorf_118429_118530_lanthipeptide NZ_NNBO01000009.1 Lanthipeptides: allorf_118429_118530_lanthipeptide NZ_NNBO01000009.1 Lanthipeptides: allorf_118429_118530_lanthipeptide
Lanthipeptides: allorf_118429_118530_lanthipeptide
1
A I S W S S C D S G S C
12
A I S S S C D S S C
6
A I S V S S C D S H S C
17
with 13 more sequence matches
Only the first 10 are displayed here.
50.0%
NZ_LISX01000002.1 and 3 others:
NZ_LISX01000002.1 Lanthipeptides: allorf_740642_740746_lanthipeptide NZ_LISX01000002.1 Lanthipeptides: allorf_740642_740746_lanthipeptide NZ_LISX01000002.1 Lanthipeptides: allorf_740642_740746_lanthipeptide
Lanthipeptides: allorf_740642_740746_lanthipeptide
1
A I S W S S C D S G S C
12
A+S S S C D S S C
7
A V S L S S C D S H S C
18
44.4%
NZ_CP085710.1:
Lanthipeptides: allorf_3217696_3217818_lanthipeptide
1
A I S W S S C D S G S C N G Q
15
+S +S C D S S C N +
1
P V S C T S C D S Y S C N K K
15
38.9%
NZ_CP048279.1 and 1 other:
NZ_LR134263.1 Lanthipeptides: allorf_2485145_2485261_lanthipeptide
Lanthipeptides: allorf_2540339_2540497_lanthipeptide
3
S W S S C D S G S C N G Q
15
S +S C + S C N G
2
S C T S C G A S S C N G P
14
35.0%
NZ_CP051301.1:
Lanthipeptides: E4O04_RS14070_lanthipeptide
3
S W S S C D S G S C N
13
S W S C S C N
1
S W G S C G H H S C N
11
35.0%
NZ_CP051302.1 and 3 others:
NZ_CP054477.1 Lanthipeptides: allorf_2300462_2300590_lanthipeptide NZ_CP058347.1 Lanthipeptides: allorf_2346513_2346641_lanthipeptide NZ_CP109619.1 Lanthipeptides: OE909_RS11400_lanthipeptide
Lanthipeptides: allorf_2256144_2256272_lanthipeptide
3
S W S S C D S G S C N
13
S W S C+ S C N
1
S W G S C N H H S C N
11
27.8%
NZ_LR130759.1:
Lanthipeptides: allorf_5440195_5440305_lanthipeptide
4
W S S C D S G S C N G Q
15
W + D+G C G
4
W G T H D A G G C G G M
15
25.9%
NZ_KQ948146.1:
Lanthipeptides: allorf_888774_889007_lanthipeptide
2
I S W S S C D S G S C N G
14
+S +S C S S C+G
11
V S L T S C T S H S C H G
23
25.0%
NZ_CP072827.1:
Lanthipeptides: J7W19_RS26345_lanthipeptide
2
I S W S S C D S G S C N G Q V I Q
18
+S +S C S C G ++
8
V S L T S C Y Q N S C A G P T L K
24
23.7%
NZ_LISX01000002.1 and 3 others:
NZ_LISX01000002.1 Lanthipeptides: allorf_740844_741005_lanthipeptide NZ_LISX01000002.1 Lanthipeptides: allorf_740844_741005_lanthipeptide NZ_LISX01000002.1 Lanthipeptides: allorf_740844_741005_lanthipeptide
Lanthipeptides: allorf_740844_741005_lanthipeptide
1
A I S W S S C D S G S C
12
+I S S S C D S S C
27
S I S V S S C D S H S C
38
21.2%
NZ_QLMA01000008.1:
Lanthipeptides: CLV59_RS22430_lanthipeptide
5
S S C D S G S C N
13
S S C D S C N
24
S S C D K N S C N
32

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.58 out of 20.97
Confidence: medium
Additional weak hits (10):
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 19.86 out of 31.73
Confidence: weak
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 19.30 out of 25.88
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.17 out of 20.01
Confidence: weak
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.62 out of 25.75
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 24.05 out of 30.97
Confidence: weak
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.99 out of 27.55
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 17.88 out of 26.06
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.50 out of 26.12
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.51 out of 28.19
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.23 out of 30.98
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

JQS30_RS10330 - Class III
  Cleavage pHMM score: -1.70
  RODEO score: 0
  Monoisotopic mass: 1709.7 Da
  Molecular weight: 1710.8 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1728.8 Da N = 1
    1746.9 Da N = 2
    1764.9 Da N = 3
JQS30_RS10335 - Class III
  Cleavage pHMM score: -2.80
  RODEO score: 0
  Monoisotopic mass: 1750.8 Da
  Molecular weight: 1751.9 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1769.9 Da N = 1
    1787.9 Da N = 2
    1805.9 Da N = 3

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A

NZ_CP070496.1 - Region 11 - ectoine
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,891,641 - 2,902,069 nt. (total: 10,429 nt) Show pHMM detection rules used
ectoine: ectoine_synt

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: aminotransferase
JQS30_RS12470: aminotransferase class-III

smcogs
  SMCOG1013: aminotransferase class-III

Isomerases: racemase
JQS30_RS12445: mandelate racemase/muconate lactonizing enzyme

smcogs
  SMCOG1268: mandelate racemase/muconate lactonizing enzyme

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ectoine | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002052.3 |  | 0.78 | other (ectoine) | ectoine | Streptomyces sp.
BGC0000853.3 |  | 0.77 | other (other) | ectoine | Streptomyces anulatus
BGC0000852.5 |  | 0.70 | other (other) | ectoine | Sporosarcina pasteurii
BGC0000858.3 |  | 0.67 | other (other) | ectoine | Methylobacter marinus
BGC0000856.3 |  | 0.66 | other (other) | ectoine | Methylophaga thalassica
BGC0000860.3 |  | 0.59 | other (other) | ectoine | Methylarcula marina
BGC0000857.3 |  | 0.59 | other (other) | ectoine | Methylophaga alcalica
BGC0000854.3 |  | 0.57 | other (other) | ectoine | Methylomicrobium alcaliphilum 20Z
BGC0000855.3 |  | 0.55 | other (other) | ectoine | Methylomicrobium kenyense
BGC0000859.3 |  | 0.55 | other (other) | ectoine | Methylomicrobium alcaliphilum

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002052.3 |  | 0.78 | other (ectoine) | ectoine | Streptomyces sp.
BGC0000853.3 |  | 0.77 | other (other) | ectoine | Streptomyces anulatus
BGC0000852.5 |  | 0.70 | other (other) | ectoine | Sporosarcina pasteurii
BGC0000858.3 |  | 0.67 | other (other) | ectoine | Methylobacter marinus
BGC0000856.3 |  | 0.66 | other (other) | ectoine | Methylophaga thalassica
BGC0000860.3 |  | 0.59 | other (other) | ectoine | Methylarcula marina
BGC0000857.3 |  | 0.59 | other (other) | ectoine | Methylophaga alcalica
BGC0000854.3 |  | 0.57 | other (other) | ectoine | Methylomicrobium alcaliphilum 20Z
BGC0000855.3 |  | 0.55 | other (other) | ectoine | Methylomicrobium kenyense
BGC0000859.3 |  | 0.55 | other (other) | ectoine | Methylomicrobium alcaliphilum

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.60 out of 19.26
Confidence: medium
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 22.05 out of 22.40
Confidence: strong
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 19.79 out of 25.31
Confidence: medium
Additional weak hits (3):
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.67 out of 21.55
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 19.09 out of 31.73
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 23.87 out of 36.53
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
CatR | H2O2-responsive repressor
HypR | L-hydroxyproline utilization repressor

NZ_CP070496.1 - Region 12 - phosphonate
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,178,875 - 3,193,784 nt. (total: 14,910 nt) Show pHMM detection rules used
phosphonate: (phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase or phosphonatesMeIsocitrateLyase))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidase
JQS30_RS13670: pyruvate oxidase/decarboxylase

smcogs
  SMCOG1055: pyruvate oxidase/decarboxylase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | phosphonate | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000938.5 |  | 0.47 | other (aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0000807.3 |  | 0.45 | saccharide | phosphonoglycans | Stackebrandtia nassauensis DSM 44728
BGC0000897.5 |  | 0.43 | other (other) | dehydrophos | Streptomyces luridus
BGC0002670.2 |  | 0.41 | other (other) | fosfonochlorin | Fusarium oxysporum f. sp. lycopersici 4287
BGC0000806.5 |  | 0.38 | saccharide | phosphonoglycans | Glycomyces sp. NRRL B-16210
BGC0000926.5 |  | 0.38 | other (other) | rhizocticin A | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001739.3 |  | 0.35 | other (other) | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0001411.3 |  | 0.35 | saccharide | polysaccharide B | Bacteroides fragilis
BGC0000937.5 |  | 0.32 | other (other) | fosfazinomycin A, fosfazinomycin B | Streptomyces sp. WM6372
BGC0000753.3 |  | 0.28 | saccharide | capsular polysaccharide | Actinobacillus pleuropneumoniae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000938.5 |  | 0.47 | other (aminocoumarin) | fosfomycin | Streptomyces fradiae
BGC0000807.3 |  | 0.45 | saccharide | phosphonoglycans | Stackebrandtia nassauensis DSM 44728
BGC0000897.5 |  | 0.43 | other (other) | dehydrophos | Streptomyces luridus
BGC0002670.2 |  | 0.41 | other (other) | fosfonochlorin | Fusarium oxysporum f. sp. lycopersici 4287
BGC0000806.5 |  | 0.38 | saccharide | phosphonoglycans | Glycomyces sp. NRRL B-16210
BGC0000926.5 |  | 0.38 | other (other) | rhizocticin A | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001739.3 |  | 0.35 | other (other) | phosphonoacetic Acid | Streptomyces sp. NRRL F-525
BGC0001411.3 |  | 0.35 | saccharide | polysaccharide B | Bacteroides fragilis
BGC0000937.5 |  | 0.32 | other (other) | fosfazinomycin A, fosfazinomycin B | Streptomyces sp. WM6372
BGC0000753.3 |  | 0.28 | saccharide | capsular polysaccharide | Actinobacillus pleuropneumoniae

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.97 out of 27.78
Confidence: medium
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 17.68 out of 19.52
Confidence: medium
Additional weak hits (4):
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.44 out of 28.19
Confidence: weak
BldD
Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.24 out of 23.43
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.11 out of 32.93
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 19.46 out of 33.14
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsQ1 | Two-component system AfsQ1-Q2, activator of antibiotic production
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria

NZ_CP070496.1 - Region 13 - NRPS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,223,810 - 3,267,796 nt. (total: 43,987 nt) Show pHMM detection rules used
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase
JQS30_RS13820: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

JQS30_RS13840: dihydropteridine reductase

smcogs
  SMCOG1159: dihydropteridine reductase

Lyases: lyase
JQS30_RS13905: argininosuccinate lyase/adenylosuccinate lyase

smcogs
  SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

JQS30_RS13910: argininosuccinate lyase/adenylosuccinate lyase

smcogs
  SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Ligases: ligase synthase
JQS30_RS13845: 2-isopropylmalate synthase

smcogs
  SMCOG1271: 2-isopropylmalate synthase

JQS30_RS13895: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

JQS30_RS13920: cysteine synthase

smcogs
  SMCOG1081: cysteine synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001641.4 |  | 0.62 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4 |  | 0.62 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001240.4 |  | 0.61 | NRPS | serinocyclin A, serinocyclin B | Metarhizium robertsii
BGC0002075.3 |  | 0.61 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0002135.2 |  | 0.61 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0000357.5 |  | 0.60 | NRPS | cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val) | Penicillium rubens Wisconsin 54-1255
BGC0001166.5 |  | 0.59 | NRPS | HC-toxin | Alternaria jesenskae
BGC0001250.4 |  | 0.59 | NRPS | epichloenin A | Epichloe festucae
BGC0001251.4 |  | 0.59 | NRPS | epichloenin A | Epichloe festucae
BGC0001268.4 |  | 0.55 | NRPS, PKS | fusarin C | Fusarium fujikuroi

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001641.4 |  | 0.62 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4 |  | 0.62 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001240.4 |  | 0.61 | NRPS | serinocyclin A, serinocyclin B | Metarhizium robertsii
BGC0002075.3 |  | 0.61 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0002135.2 |  | 0.61 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0000357.5 |  | 0.60 | NRPS | cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val) | Penicillium rubens Wisconsin 54-1255
BGC0001166.5 |  | 0.59 | NRPS | HC-toxin | Alternaria jesenskae
BGC0001250.4 |  | 0.59 | NRPS | epichloenin A | Epichloe festucae
BGC0001251.4 |  | 0.59 | NRPS | epichloenin A | Epichloe festucae
BGC0001268.4 |  | 0.55 | NRPS, PKS | fusarin C | Fusarium fujikuroi

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 19.35 out of 20.47
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 16.89 out of 20.97
Confidence: medium
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 25.04 out of 29.72
Confidence: medium
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 21.38 out of 27.04
Confidence: medium
Additional weak hits (8):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 17.25 out of 26.06
Confidence: weak
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.51 out of 21.84
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 16.91 out of 20.01
Confidence: weak
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 18.34 out of 27.78
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.98 out of 29.25
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 19.03 out of 29.38
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 19.96 out of 30.25
Confidence: weak
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 21.74 out of 29.72
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 18, location 3223809 - 3267796:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Gln)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
JQS30_RS13895: Gln
Search NORINE for peptide: strict or relaxed
AMP-binding (23..468): Gln
nrpys: Gln

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    QWMTFDAAQWESQCFSGGEVNLYGPTECTINSTF
  Nearest Stachelhaus code(s):
    Gln DAWQFGLINK (85% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
DasR | N-acetylglucosamine dependent repressor
NtrC | Nitrogen regulatory protein C
VqsM | Regulator of quorum-sensing signalling systems

NZ_CP070496.1 - Region 14 - hydrogen-cyanide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,660,621 - 3,673,486 nt. (total: 12,866 nt) Show pHMM detection rules used
hydrogen-cyanide: (Fer2_4 and cds(Pyr_redox_2 and Fer2_BFD) and DAO)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase reductase
JQS30_RS15605: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

JQS30_RS15620: FAD dependent oxidoreductase

smcogs
  SMCOG1103: FAD dependent oxidoreductase

JQS30_RS15640: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs
  SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

JQS30_RS17595: alkyl hydroperoxide reductase subunit

smcogs
  SMCOG1176: alkyl hydroperoxide reductase subunit

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | hydrogen-cyanide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001633.3 |  | 0.43 | other (other) | ketomemicin B3, ketomemicin B4 | Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0000577.3 |  | 0.37 | ribosomal | sphingonodin II | Sphingobium japonicum UT26S
BGC0002285.2 |  | 0.35 | ribosomal | aborycin | Streptomyces sp. ZS0098
BGC0001302.5 |  | 0.35 | other (other) | lomofungin | Streptomyces lomondensis
BGC0001012.3 |  | 0.33 | NRPS, PKS | meridamycin | Streptomyces violaceusniger
BGC0000813.3 |  | 0.32 | other (other) | K-252a | Nonomuraea longicatena
BGC0000126.5 |  | 0.32 | PKS | pladienolide B | Streptomyces platensis
BGC0002083.3 |  | 0.32 | PKS | gladiofungin A, gladiofungin B | Burkholderia gladioli
BGC0001726.4 |  | 0.32 | NRPS, PKS | pactamide A, pactamide B, pactamide C, pactamide D, pactamide E, pactamide F | Streptomyces pactum
BGC0000058.5 |  | 0.32 | PKS | FD-891 | Streptomyces graminofaciens

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001633.3 |  | 0.43 | other (other) | ketomemicin B3, ketomemicin B4 | Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0000577.3 |  | 0.37 | ribosomal | sphingonodin II | Sphingobium japonicum UT26S
BGC0002285.2 |  | 0.35 | ribosomal | aborycin | Streptomyces sp. ZS0098
BGC0001302.5 |  | 0.35 | other (other) | lomofungin | Streptomyces lomondensis
BGC0001012.3 |  | 0.33 | NRPS, PKS | meridamycin | Streptomyces violaceusniger
BGC0000813.3 |  | 0.32 | other (other) | K-252a | Nonomuraea longicatena
BGC0000126.5 |  | 0.32 | PKS | pladienolide B | Streptomyces platensis
BGC0002083.3 |  | 0.32 | PKS | gladiofungin A, gladiofungin B | Burkholderia gladioli
BGC0001726.4 |  | 0.32 | NRPS, PKS | pactamide A, pactamide B, pactamide C, pactamide D, pactamide E, pactamide F | Streptomyces pactum
BGC0000058.5 |  | 0.32 | PKS | FD-891 | Streptomyces graminofaciens

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.07 out of 26.85
Confidence: medium
Additional weak hits (1):
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.51 out of 39.62
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
RutR | Regulator of the pyrimidine and purine metabolism

NZ_CP070496.1 - Region 15 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,764,510 - 3,787,851 nt. (total: 23,342 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
JQS30_RS16060: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

Lyases: cyclase
JQS30_RS16105: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000554.4 |  | 0.70 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000626.3 |  | 0.56 | ribosomal | thuricin | Bacillus thuringiensis
BGC0001555.4 |  | 0.52 | ribosomal | colicin V | Escherichia coli chi7122
BGC0000516.4 |  | 0.52 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000590.5 |  | 0.51 | ribosomal | microcin N | Escherichia coli
BGC0002005.2 |  | 0.51 | ribosomal | RaxX | Xanthomonas oryzae pv. oryzae
BGC0000525.5 |  | 0.51 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0002698.2 |  | 0.50 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0000528.5 |  | 0.50 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000588.5 |  | 0.49 | ribosomal | microcin L | Escherichia coli

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000554.4 |  | 0.70 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000626.3 |  | 0.56 | ribosomal | thuricin | Bacillus thuringiensis
BGC0001555.4 |  | 0.52 | ribosomal | colicin V | Escherichia coli chi7122
BGC0000516.4 |  | 0.52 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000590.5 |  | 0.51 | ribosomal | microcin N | Escherichia coli
BGC0002005.2 |  | 0.51 | ribosomal | RaxX | Xanthomonas oryzae pv. oryzae
BGC0000525.5 |  | 0.51 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0002698.2 |  | 0.50 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0000528.5 |  | 0.50 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000588.5 |  | 0.49 | ribosomal | microcin L | Escherichia coli

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for JQS30_RS16105

JQS30_RS16095
Leader:
MNAIRAWKDPEYRAGLSNEELAELPANPVGIAELPEGQLDSVGGG
Core:
T T W G C A T V T L T V T V C S P T N T M C G S C S W G T S G C C
Core with dehydrations:
Dhb Dhb W G Cys A Dhb V Dhb L Dhb V Dhb V Cys Dha P Dhb N Dhb M Cys G Dha Cys Dha W G Dhb Dha G Cys Cys

#### antiSMASH-DB 4.0 matches for JQS30_RS16095

100.0%
NZ_CP070496.1:
Lanthipeptides: JQS30_RS16095_lanthipeptide
1
T T W G C A T V T L T V T V C S P T N T M C G S C S W G T S G C C
33
T T W G C A T V T L T V T V C S P T N T M C G S C S W G T S G C C
1
T T W G C A T V T L T V T V C S P T N T M C G S C S W G T S G C C
33
84.8%
NZ_DS999644.1 and 2 others:
NZ_LACR01000025.1 Lanthipeptides: YW5_RS27795_lanthipeptide NZ_ML123034.1 Lanthipeptides: EES43_RS16615_lanthipeptide
Lanthipeptides: SSGG_RS13165_lanthipeptide
1
T T W G C A T V T L T V T V C S P T N T M C G S C S W G T S G C C
33
T T W C A T V T L T V T V C S P T T+C G S C S G T G C C
1
T T W A C A T V T L T V T V C S P T G T L C G S C S M G T R G C C
33
81.8%
NZ_BMTW01000001.1 and 1 other:
NZ_KZ268499.1 Lanthipeptides: CE422_RS19980_lanthipeptide
Lanthipeptides: IE134_RS03420_lanthipeptide
1
T T W G C A T V T L T V T V C S P T N T M C G S C S W G T S G C C
33
T T W C A T+T L T V T V C S P T T+C G S C S G T G C C
1
T T W A C A T I T L T V T V C S P T G T L C G S C S M G T R G C C
33
with 23 more sequence matches
Only the first 10 are displayed here.
71.4%
NZ_FNAD01000024.1:
Lanthipeptides: BLQ63_RS26045_lanthipeptide
1
T T W G C--A T V T L T V T V C S P T N T M C G S C S W G T S G C C
33
+T W G C A T+ L T V T V C S P T T+C G S C G T G C C
1
S T W G C V T A T I A L T V T V C S P T G T L C G S C Q M G T R G C C
35
55.3%
NZ_CP013979.1:
Lanthipeptides: allorf_0343557_0343787_lanthipeptide
1
T T W G C A T V T L T V T V----C S P T N T M C G S C S W G T S G C C
33
T W C A T V++ V + C S P T C G S C++G T S G C C
1
T G W A C A T V S I G V G I S L A W C S P G G T F C G S C T F G T S G C C
37
41.2%
NZ_CP014228.1:
Lanthipeptides: AXF14_RS11840_lanthipeptide
6
A T V T L T V T V C S P T N T M C G S C S W G T S G C C
33
A V T V T C + G S C G T G C C
7
A F V V T T V T A C W N D T A L W G S C R L G T R G C C
34
39.4%
NZ_BNAY01000019.1:
Lanthipeptides: IE302_RS42045_lanthipeptide
1
T T W G C A T V T L T V T--V C S P T N T M C G S C S W G T S G C C
33
+T C T+ +T V+ V C P T ++G+ G C C
2
S T I P C V T L P I T V S A A V C V P T K------N F G S I G C C
30
35.1%
NZ_LR027842.1:
Lanthipeptides: E0E39_RS01490_lanthipeptide
15
C S P T N T M C G S C S W G T S G C C
33
C S P T+C G S C G T G C C
19
C S P D G T L C G S C Q M G T R G C C
37
29.4%
NZ_GL405260.1:
Lanthipeptides: allorf_2499753_2499935_lanthipeptide
8
V T L T V T V C S P T N T M C G S C S W G T S G C C
33
+ T+T C + G S C G T C C
9
I I A T L T Q C F N D T L V W G S C R L G T R A C C
34
27.3%
NZ_JABBGE010000004.1 and 1 other:
NZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13570_lanthipeptide
Lanthipeptides: HHL19_RS13570_lanthipeptide
1
T T W G C A T V T L T V T V C S
16
T T W C A V T T+ S
1
T T W S C A V V T A V A T L V S
16
27.3%
NZ_LMEI01000006.1 and 1 other:
NZ_LMEI01000006.1 Lanthipeptides: ASC82_RS30550_lanthipeptide
Lanthipeptides: ASC82_RS30550_lanthipeptide
1
T T W G C A T V T L T V T V C S
16
T T W C A V T T+ S
1
T T W S C A I V T A V A T L V S
16
27.3%
NZ_QORY01000016.1 and 1 other:
NZ_QORY01000016.1 Lanthipeptides: DT250_RS18265_lanthipeptide
Lanthipeptides: DT250_RS18265_lanthipeptide
1
T T W G C A T V T L T V T V C S P T
18
T T W G C A T+ P T
8
T T W G C A I F T I A S A A Q C P T
25
24.2%
NZ_FNPT01000003.1:
Lanthipeptides: allorf_246742_246903_lanthipeptide
10
L T V T V C S P T N T M C G S C S W G
28
L V P T N G+ W G
11
L D V R H E K P T N D G V G A A V W G
29

#### MIBiG 4.0 matches for JQS30_RS16095

12.1%
BGC0000503.5 (cinA):
Lanthipeptide: cinnamycin
24
S C S W G
28
S C S+G
4
S C S F G
8
allorf_3767835_3767960
Leader:
MAGRNHMVPAG
Core:
F C V R G P H P T A Q Q S A H R T R R R K R I S P W Q R R N
Core with dehydrations:
F Cys V R G P H P Dhb A Q Q Dha A H R Dhb R R R K R I Dha P W Q R R N

#### antiSMASH-DB 4.0 matches for allorf_3767835_3767960

100.0%
NZ_CP070496.1:
Lanthipeptides: allorf_3767835_3767960_lanthipeptide
1
F C V R G P H P T A Q Q S A H R T R R R K R I S P W Q R R N
30
F C V R G P H P T A Q Q S A H R T R R R K R I S P W Q R R N
1
F C V R G P H P T A Q Q S A H R T R R R K R I S P W Q R R N
30
allorf_3767860_3768009
Leader:
MRFLRRVRWA
Core:
D C C A V G C G P R T Q K P A G T M W F R P A I P Y L A E G L L S L G R V L L
Core with dehydrations:
D Cys Cys A V G Cys G P R Dhb Q K P A G Dhb M W F R P A I P Y L A E G L L Dha L G R V L L

#### antiSMASH-DB 4.0 matches for allorf_3767860_3768009

100.0%
NZ_CP070496.1:
Lanthipeptides: allorf_3767860_3768009_lanthipeptide
1
D C C A V G C G P R T Q K P A G T M W F R P A I P Y L A E G L L S L G R V L L
39
D C C A V G C G P R T Q K P A G T M W F R P A I P Y L A E G L L S L G R V L L
1
D C C A V G C G P R T Q K P A G T M W F R P A I P Y L A E G L L S L G R V L L
39
21.4%
NZ_JAASAG010000001.1 and 1 other:
NZ_JAASAG010000001.1 Lanthipeptides: allorf_352495_352659_lanthipeptide
Lanthipeptides: allorf_352495_352659_lanthipeptide
6
G C G P R T Q K P A G T M W F R P A I P Y L A E G L L
32
G C G A P+ P+L G+L
7
G C G E D G V S A A V P R N V S P S A P F L R S G M L
33
20.8%
NZ_FNIE01000012.1:
Lanthipeptides: allorf_231668_231853_lanthipeptide
3
C A V G C G P R T Q K P A G T M W F R P A I P Y L A E G L L S L G R V L
38
C + C G + T W P + L G L L + L
5
C R M E C G G L P H R R R A T Y W A L P R V C S L G P G L R R L D Q P L
40
with 2 more sequence matches
20.5%
NZ_CP016795.1 and 1 other:
NZ_CP016795.1 Lanthipeptides: allorf_4197591_4197734_lanthipeptide
Lanthipeptides: allorf_4197591_4197734_lanthipeptide
4
A V G C G P R T Q K P A G
16
+V G G P R T P G
20
S V G M G P R T F L P K G
32
16.7%
NZ_AP023392.1 and 3 others:
NZ_CP015557.1 Lanthipeptides: allorf_0952604_0952840_lanthipeptide NZ_CP100430.1 Lanthipeptides: allorf_0940325_0940561_lanthipeptide NZ_JAEUXF010000003.1 Lanthipeptides: allorf_111883_112119_lanthipeptide
Lanthipeptides: allorf_0989669_0989905_lanthipeptide
17
T M W F R P A I P Y L A E--G L L S L G R V
37
T W R P P L L R V
32
T W W L R P Q T P K K K S R V D F L K L D R V
54
allorf_3770370_3770519
Leader:
MRFDRRHFLVAA
Core:
L R L P H A P C P M P Q G T L Y E S A F I K R S E L I L L I F H L I F A Q
Core with dehydrations:
L R L P H A P Cys P M P Q G Dhb L Y E Dha A F I K R Dha E L I L L I F H L I F A Q

#### antiSMASH-DB 4.0 matches for allorf_3770370_3770519

100.0%
NZ_CP070496.1:
Lanthipeptides: allorf_3770370_3770519_lanthipeptide
1
L R L P H A P C P M P Q G T L Y E S A F I K R S E L I L L I F H L I F A Q
37
L R L P H A P C P M P Q G T L Y E S A F I K R S E L I L L I F H L I F A Q
1
L R L P H A P C P M P Q G T L Y E S A F I K R S E L I L L I F H L I F A Q
37
16.2%
NZ_CYZG01000001.1:
Lanthipeptides: allorf_015972_016097_lanthipeptide
5
H A P C P M P Q G T L Y E S A F I
21
+ C P+ +L+ S A F+
4
Y I S C P V I W K S L F R S A F V
20
allorf_3770845_3770946
Leader:
MNMRIFGYFLESMNGI
Core:
T P C C S A Q E E T D I T S V G S
Core with dehydrations:
Dhb P Cys Cys Dha A Q E E Dhb D I Dhb Dha V G Dha

#### antiSMASH-DB 4.0 matches for allorf_3770845_3770946

100.0%
NZ_CP070496.1:
Lanthipeptides: allorf_3770845_3770946_lanthipeptide
1
T P C C S A Q E E T D I T S V G S
17
T P C C S A Q E E T D I T S V G S
1
T P C C S A Q E E T D I T S V G S
17
29.4%
NZ_CP028286.1:
Lanthipeptides: allorf_099257_099355_lanthipeptide
4
C S A Q E E T D I
12
C A E+T D+
1
C G A H E K T D L
9
11.1%
NZ_CP110813.1:
Lanthipeptides: allorf_3259340_3259546_lanthipeptide
1
T P C C S A Q E E T D I
12
T P C C+A I
3
T P C C A A A A R G R I
14
allorf_3773540_3773689
Leader:
MRQLGRMREIVRA
Core:
A P K A S D K N R D L C R R A H S S P E E S I G I R M N D E K S D L E A
Core with dehydrations:
A P K A Dha D K N R D L Cys R R A H Dha Dha P E E Dha I G I R M N D E K Dha D L E A

#### antiSMASH-DB 4.0 matches for allorf_3773540_3773689

100.0%
NZ_CP070496.1:
Lanthipeptides: allorf_3773540_3773689_lanthipeptide
1
A P K A S D K N R D L C R R A H S S P E E S I G I R M N D E K S D L E A
36
A P K A S D K N R D L C R R A H S S P E E S I G I R M N D E K S D L E A
1
A P K A S D K N R D L C R R A H S S P E E S I G I R M N D E K S D L E A
36
24.5%
NZ_AKXV01000031.1:
Lanthipeptides: allorf_129695_129928_lanthipeptide
10
D L C R R A H S----S P E E S I G I R M N D E K S D L
34
+L C R R A S P G I +N D L
2
E L C R R A G S R C R R Q P R P E C G I-L N G M G G D L
29
19.4%
NZ_CP011509.1:
Lanthipeptides: allorf_08187200_08187328_lanthipeptide
9
R D L C R R A H S S P E
20
R L C R R + P E
16
R S L C R R G G A G P E
27
with 1 more sequence matches
15.4%
NZ_JAQCXO010000012.1:
Lanthipeptides: allorf_080217_080393_lanthipeptide
5
S D K N R D L C R R A H S S P E E S I
23
+ +N L C R H P++ +
15
A T Q N L H L C A R M H C L P Q Q Y V
33
allorf_3773571_3773729
Leader:
MRIPILSSGLECARLHKSRFLSDAFGA
Core:
A R T I S R I L P N W R K Y Y L V V P T T P T C V
Core with dehydrations:
A R Dhb I Dha R I L P N W R K Y Y L V V P Dhb Dhb P Dhb Cys V

#### antiSMASH-DB 4.0 matches for allorf_3773571_3773729

100.0%
NZ_CP070496.1:
Lanthipeptides: allorf_3773571_3773729_lanthipeptide
1
A R T I S R I L P N W R K Y Y L V V P T T P T C V
25
A R T I S R I L P N W R K Y Y L V V P T T P T C V
1
A R T I S R I L P N W R K Y Y L V V P T T P T C V
25
28.0%
NZ_CP007155.1:
Lanthipeptides: allorf_3816161_3816271_lanthipeptide
5
S R I L P N W R K Y Y L
16
R I L P+ Y Y L
6
G R I L P H G A S Y Y L
17
17.1%
NZ_CP019286.1:
Lanthipeptides: allorf_095362_095517_lanthipeptide
12
R K Y Y L V V P T T P T C V
25
R + V+P P T C V
2
R D F R P V I P R Y P T C V
15

#### MIBiG 4.0 matches for allorf_3773571_3773729

16.0%
BGC0000581.6 (AAD28494.1):
Lasso peptide: microcin J25
15
Y L V V P T T P
22
Y V T P
9
Y F V G I G T P
16
16.0%
BGC0000582.4 (ADR72962.1):
Linaridin: cypemycin
19
P T T P T
23
P T P T
3
P A T P T
7
allorf_3774399_3774488
Leader:
MVRVFKVNEVAG
Core:
R L I G K V E R P C R S G L H R K
Core with dehydrations:
R L I G K V E R P Cys R Dha G L H R K

#### antiSMASH-DB 4.0 matches for allorf_3774399_3774488

100.0%
NZ_CP070496.1:
Lanthipeptides: allorf_3774399_3774488_lanthipeptide
1
R L I G K V E R P C R S G L H R K
17
R L I G K V E R P C R S G L H R K
1
R L I G K V E R P C R S G L H R K
17
35.3%
NZ_LMEI01000006.1:
Lanthipeptides: allorf_388828_388947_lanthipeptide
4
G K V E R P C R S G
13
G R P C S G
6
G H A A R P C P S G
15
15.7%
NZ_BMSB01000008.1:
Lanthipeptides: allorf_182878_183105_lanthipeptide
1
R L I G K V E R P C R S
12
R L I G +P C R S
4
R L I G W A G Q P C R S
15
with 2 more sequence matches
13.3%
NZ_LMHM01000013.1:
Lanthipeptides: allorf_277037_277234_lanthipeptide
7
E R P C R S G L H R K
17
+ P C R S G R
28
D A P C R S G A S R D
38
11.6%
NZ_DF978419.1:
Lanthipeptides: allorf_0450693_0450881_lanthipeptide
5
K V E R P C R S G L
14
++ P C R S G+
1
R I A S P C R S G I
10
allorf_3783783_3783950
Leader:
MVRQHEITCA
Core:
A Q Q M I T R P Q R P Q Q S R A P H S T Q E S R C V S S V W S R D C G W M I V G S P Q I K
Core with dehydrations:
A Q Q M I Dhb R P Q R P Q Q Dha R A P H Dha Dhb Q E Dha R Cys V Dha Dha V W Dha R D Cys G W M I V G Dha P Q I K

#### antiSMASH-DB 4.0 matches for allorf_3783783_3783950

100.0%
NZ_CP070496.1:
Lanthipeptides: allorf_3783783_3783950_lanthipeptide
1
A Q Q M I T R P Q R P Q Q S R A P H S T Q E S R C V S S V W S R D C G W M I V G S P Q I K
45
A Q Q M I T R P Q R P Q Q S R A P H S T Q E S R C V S S V W S R D C G W M I V G S P Q I K
1
A Q Q M I T R P Q R P Q Q S R A P H S T Q E S R C V S S V W S R D C G W M I V G S P Q I K
45
20.0%
NZ_JAMXMK010000009.1:
Lanthipeptides: NGM22_RS28130_lanthipeptide
17
P H S T Q E S R C V S S V W S R D C G W M I V
39
P S T C S W R C W
5
P E S T P P F A C D Y S C W F R H C D W Y C C
27
17.8%
NZ_CP012102.1 and 3 others:
NZ_CP012102.1 Lanthipeptides: AC241_RS34125_lanthipeptide NZ_JAMXMK010000009.1 Lanthipeptides: NGM22_RS28050_lanthipeptide NZ_JAMXMK010000009.1 Lanthipeptides: NGM22_RS28050_lanthipeptide
Lanthipeptides: AC241_RS34125_lanthipeptide
17
P H S T Q E S R C V S S V W S R D C G W M I V
39
P +T C S W R C W
5
P E T T P P F A C D Y S C W F R H C D W Y C C
27
with 1 more sequence matches
15.6%
NZ_JAASAG010000001.1:
Lanthipeptides: allorf_346005_346232_lanthipeptide
12
Q Q S R A P H S T Q E S R C V S
27
++R A H T E C S
1
D R A R A H H G T S E Q A C T S
16
allorf_3786763_3786897
Leader:
MLRRRACGKRCHYWYRAAGRFAGA
Core:
W C L G G F A S L E W P P P G R S G S T
Core with dehydrations:
W Cys L G G F A Dha L E W P P P G R Dha G Dha Dhb

#### antiSMASH-DB 4.0 matches for allorf_3786763_3786897

100.0%
NZ_CP070496.1:
Lanthipeptides: allorf_3786763_3786897_lanthipeptide
1
W C L G G F A S L E W P P P G R S G S T
20
W C L G G F A S L E W P P P G R S G S T
1
W C L G G F A S L E W P P P G R S G S T
20
21.6%
NZ_CP061072.1:
Lanthipeptides: allorf_5574385_5574531_lanthipeptide
3
L G G F A S L E W P P P G R
16
L A S L P P P R
22
L D R R A S L R L P P P V R
35
8.3%
NZ_FOGM01000011.1:
Lanthipeptides: allorf_00061_00258_lanthipeptide
10
E W P P P G R S G S
19
+P P P R+ +
21
R F P P P S R T T A
30
allorf_3786998_3787234
Leader:
MGLFVWVHPRVRGEHFDPSLEGLVLYGS
Core:
S P R A R G A L L W R C G S S P P L G F I P A C A G S I Q I I T V C D G L S W V H P R V R G E H T S
Core with dehydrations:
Dha P R A R G A L L W R Cys G Dha Dha P P L G F I P A Cys A G Dha I Q I I Dhb V Cys D G L Dha W V H P R V R G E H Dhb Dha

#### antiSMASH-DB 4.0 matches for allorf_3786998_3787234

100.0%
NZ_CP070496.1:
Lanthipeptides: allorf_3786998_3787234_lanthipeptide
1
S P R A R G A L L W R C G S S P P L G F I P A C A G S I Q I I T V C D G L S W V H P R V R G E H T S
50
S P R A R G A L L W R C G S S P P L G F I P A C A G S I Q I I T V C D G L S W V H P R V R G E H T S
1
S P R A R G A L L W R C G S S P P L G F I P A C A G S I Q I I T V C D G L S W V H P R V R G E H T S
50
32.7%
NZ_CP070496.1:
Lanthipeptides: allorf_3787427_3787648_lanthipeptide
1
S P R A R G A L L W R C G S S P P L G F I P A C A G S I
28
S P R A R G A +G F I P A C A G S I
24
S P R A R G A F T G E V A C D V A V G F I P A C A G S I
51
32.0%
NZ_RCOL01000001.1:
Lanthipeptides: allorf_2499994_2500137_lanthipeptide
2
P R A R G A L L--W R C G S S P P L G F I P A C A G S I
28
P R A R G W R S S P G P A C A G+
10
P R A R G P R T R P W R A W S S P--G T T P A C A G T T
36
with 5 more sequence matches
22.0%
NZ_FNYB01000007.1 and 2 others:
NZ_JAIPUK010000011.1 Lanthipeptides: K9P71_RS27185_lanthipeptide NZ_KB976303.1 Lanthipeptides: IGY_RS27690_lanthipeptide
Lanthipeptides: BMZ34_RS15965_lanthipeptide
22
P A C A G S---I Q I I T V C D G L S W V H
41
P A C A + +Q +T V G L S +H
9
P A C A S A M L Y L Q G V T V S L G L S R M H
31
17.3%
NZ_CP070496.1:
Lanthipeptides: allorf_3787427_3787648_lanthipeptide
41
H P R V R G E H T S
50
H P R V R G E H+S
3
H P R V R G E H S S
12
16.0%
NZ_QGTL01000006.1:
Lanthipeptides: allorf_311998_312129_lanthipeptide
19
G F I P A C A G S
27
G I P A C A G S
9
G L I P A C A G S
17
14.0%
NZ_CP077652.1:
Lanthipeptides: allorf_2255880_2256005_lanthipeptide
41
H P R V R G E H T S
50
H P R R G+H+S
24
H P R S R G D H S S
33
10.3%
NZ_JADPCB010000055.1:
Lanthipeptides: I4W51_RS17005_lanthipeptide
34
C D G L S W V H P
42
C D G W V P
41
C D G T D W V L P
49

#### MIBiG 4.0 matches for allorf_3786998_3787234

14.0%
BGC0000563.4 (AEA03263.1):
Lanthipeptide: venezuelin
24
C A G S I Q I I-T V C D G L S
38
C G + ++ T V C G+S
5
C V G L L T L L N T V C I G I S
20
10.0%
BGC0002144.3 (RCCGEPOP_RS37510):
LAP: phazolicin
7
A L L W R C G S S P
16
A R C S S
1
A T C A R C D S S S
10
allorf_3787129_3787275
Leader:
MLPAHAGM
Core:
N R R E P N P L V R D Q N A P R A R G D E P I R T A P I I R V V L C S P R T R G
Core with dehydrations:
N R R E P N P L V R D Q N A P R A R G D E P I R Dhb A P I I R V V L Cys Dha P R Dhb R G

#### antiSMASH-DB 4.0 matches for allorf_3787129_3787275

100.0%
NZ_CP070496.1:
Lanthipeptides: allorf_3787129_3787275_lanthipeptide
1
N R R E P N P L V R D Q N A P R A R G D E P I R T A P I I R V V L C S P R T R G
40
N R R E P N P L V R D Q N A P R A R G D E P I R T A P I I R V V L C S P R T R G
1
N R R E P N P L V R D Q N A P R A R G D E P I R T A P I I R V V L C S P R T R G
40
55.0%
NZ_CP070496.1:
Lanthipeptides: allorf_3787251_3787397_lanthipeptide
6
N P L V R D Q N A P R A R G D E P---I R T A P I I R V V L C S P R T R G
40
N V ++A P R A R G D E P R T+P +R C S P R T R G
6
N S Y V A T R D A P R A R G D E P R Q T N R T S P T M R---C S P R T R G
40
52.5%
NZ_CP070496.1:
Lanthipeptides: allorf_3787373_3787519_lanthipeptide
1
N R R E P N P L V R D Q N A P R A R G D E P I R T A P I I R V V L C S P R T R G
40
N R R N A P R A R G D E P R C S P R T R G
1
N R R S I Q V W Q C S W N A P R A R G D E P Y R N I A G H L A G E C S P R T R G
40
with 8 more sequence matches
20.0%
NZ_CP011129.1:
Lanthipeptides: allorf_3813487_3813657_lanthipeptide
11
D Q N A P R A R G D E P I R T A P I I R V V L C S
35
Q A R +P R P V+ C+
3
G Q G A Q G G R P G K P A R A G P P A A V I A C A
27
20.0%
NZ_CP013141.1:
Lanthipeptides: allorf_5320283_5320453_lanthipeptide
11
D Q N A P R A R G D E P I R T A P I I R V V L C S
35
Q A R +P R P + V+ C+
3
G Q G A Q G G R P G Q P A R A E P P V A V I A C A
27
20.0%
NZ_CP070496.1:
Lanthipeptides: allorf_3787434_3787580_lanthipeptide
33
L C S P R T R G
40
L C S P R T R G
9
L C S P R T R G
16
19.0%
NZ_CP020563.1:
Lanthipeptides: allorf_2379503_2379736_lanthipeptide
12
Q N A P R A R G D E P I R T A P I I R V V L C S P R T R G
40
P R R G P + S P R T R G
1
M G G P R V R G G V P S S V G V S V I R A R W S P R T R G
29
18.8%
NZ_FPCC01000026.1:
Lanthipeptides: BM377_RS12905_lanthipeptide
10
R D Q N A P R A R G D E P I R T A P I I R V V L C S P R
37
D + G D T P+I + C S P
8
E D M Q N T Q G A G D V D A E T T P V I M P I-C S P S
34
15.0%
NZ_CP068102.1 and 1 other:
NZ_CP068102.1 Lanthipeptides: allorf_1181240_1181359_lanthipeptide
Lanthipeptides: allorf_1181240_1181359_lanthipeptide
25
T A P I I R V V L C S P R T R G
40
+ ++ V+ C S P R G
2
S Q K L M F V I Y C S P H L R G
17
14.8%
NZ_CDME01000002.1:
Lanthipeptides: allorf_0030628_0030822_lanthipeptide
18
R G D E P I R T A P I I R V
31
R G D P+R A +I R+
18
R G D R P L R G A R L I R L
31
14.8%
NZ_CP070496.1:
Lanthipeptides: allorf_3787495_3787722_lanthipeptide
14
A P R A R G D E P I
23
A P R A R G D E P+
8
A P R A R G D E P L
17

#### MIBiG 4.0 matches for allorf_3787129_3787275

12.5%
BGC0000553.3 (SSGG_RS09925):
Lanthipeptide: SRO15-2212
29
I R V V L C S P
36
+ V V L C+P
15
L S V V L C T P
22
allorf_3787251_3787397
Leader:
MLPAHAGM
Core:
N L N R I N S Y V A T R D A P R A R G D E P R Q T N R T S P T M R C S P R T R G
Core with dehydrations:
N L N R I N Dha Y V A Dhb R D A P R A R G D E P R Q Dhb N R Dhb Dha P Dhb M R Cys Dha P R Dhb R G

#### antiSMASH-DB 4.0 matches for allorf_3787251_3787397

100.0%
NZ_CP070496.1:
Lanthipeptides: allorf_3787251_3787397_lanthipeptide
1
N L N R I N S Y V A T R D A P R A R G D E P R Q T N R T S P T M R C S P R T R G
40
N L N R I N S Y V A T R D A P R A R G D E P R Q T N R T S P T M R C S P R T R G
1
N L N R I N S Y V A T R D A P R A R G D E P R Q T N R T S P T M R C S P R T R G
40
55.0%
NZ_CP070496.1:
Lanthipeptides: allorf_3787129_3787275_lanthipeptide
6
N S Y V A T R D A P R A R G D E P R Q T N R T S P T M R---C S P R T R G
40
N V ++A P R A R G D E P R T+P +R C S P R T R G
6
N P L V R D Q N A P R A R G D E P---I R T A P I I R V V L C S P R T R G
40
42.5%
NZ_CP070496.1:
Lanthipeptides: allorf_3787373_3787519_lanthipeptide
5
I N S Y V A T R D A P R A R G D E P R Q T N R T S P T M R C S P R T R G
40
I + + +A P R A R G D E P + C S P R T R G
5
I Q V W Q C S W N A P R A R G D E P Y R N I A G H L A G E C S P R T R G
40
with 8 more sequence matches
35.0%
NZ_CP047146.1:
Lanthipeptides: allorf_3666144_3666341_lanthipeptide
14
A P R A R G D E P------R Q T N R T S P T M R C S P R T R
39
A P +R D E P R+ R T S P C+ R R
1
A P D S R A D E P A H P Q T H R R R T R T S P E T W C A V R H R
32
22.5%
NZ_JAPTYM010000001.1:
Lanthipeptides: allorf_00315602_00315700_lanthipeptide
16
R A R G D E P R Q T N R T S P
30
R R G+ P Q T R T P
2
R Q R G E V P C Q T P R T R P
16
22.5%
NZ_NTWJ01000043.1 and 1 other:
NZ_NTWJ01000043.1 Lanthipeptides: CN427_RS31525_lanthipeptide
Lanthipeptides: CN427_RS31525_lanthipeptide
17
A R G D E P R Q T-N R T S P T M R C S
35
A G Q T ++T P T+ C S
17
A V G T W V F Q T S D K T C P T L A C S
36
22.5%
NZ_NTWJ01000043.1 and 1 other:
NZ_NTWJ01000043.1 Lanthipeptides: CN427_RS29340_lanthipeptide
Lanthipeptides: CN427_RS29340_lanthipeptide
17
A R G D E P R Q T N-R T S P T M R C S
35
A G Q T+ +T P T+ C S
17
A V G T W V F Q T S E K T C P T L A C S
36
20.7%
NZ_CP020563.1:
Lanthipeptides: allorf_2379503_2379736_lanthipeptide
13
D A P R A R G D E P R Q T N R T S P T M R C S P R T R G
40
P R R G P + R S P R T R G
2
G G P R V R G G V P S S V G V S V I R A R W S P R T R G
29
20.0%
NZ_CP070496.1:
Lanthipeptides: allorf_3787434_3787580_lanthipeptide
28
T S P T M R C S P R T R G
40
T+ + C S P R T R G
4
T A S S E L C S P R T R G
16
20.0%
NZ_JANIOB010000033.1:
Lanthipeptides: NQ113_RS28010_lanthipeptide
22
P R Q T N R T S P T M R C S P R T
38
P T N R P T+ C+ R
13
P G F T N R L C P T I P C T L R V
29
16.4%
NZ_CP070496.1:
Lanthipeptides: allorf_3787495_3787722_lanthipeptide
14
A P R A R G D E P R Q T N R
27
A P R A R G D E P R
8
A P R A R G D E P L P P A R
21

#### MIBiG 4.0 matches for allorf_3787251_3787397

10.0%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
30
P T M R C S P R
37
P T +C+ R
29
P T T K C T S R
36
7.5%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
29
S P T M R C S P R
37
P T +C+ +
17
C P T T K C T S K
25
allorf_3787373_3787519
Leader:
MLPAHAGM
Core:
N R R S I Q V W Q C S W N A P R A R G D E P Y R N I A G H L A G E C S P R T R G
Core with dehydrations:
N R R Dha I Q V W Q Cys Dha W N A P R A R G D E P Y R N I A G H L A G E Cys Dha P R Dhb R G

#### antiSMASH-DB 4.0 matches for allorf_3787373_3787519

100.0%
NZ_CP070496.1:
Lanthipeptides: allorf_3787373_3787519_lanthipeptide
1
N R R S I Q V W Q C S W N A P R A R G D E P Y R N I A G H L A G E C S P R T R G
40
N R R S I Q V W Q C S W N A P R A R G D E P Y R N I A G H L A G E C S P R T R G
1
N R R S I Q V W Q C S W N A P R A R G D E P Y R N I A G H L A G E C S P R T R G
40
52.5%
NZ_CP070496.1:
Lanthipeptides: allorf_3787129_3787275_lanthipeptide
1
N R R S I Q V W Q C S W N A P R A R G D E P Y R N I A G H L A G E C S P R T R G
40
N R R N A P R A R G D E P R C S P R T R G
1
N R R E P N P L V R D Q N A P R A R G D E P I R T A P I I R V V L C S P R T R G
40
42.5%
NZ_CP070496.1:
Lanthipeptides: allorf_3787251_3787397_lanthipeptide
5
I Q V W Q C S W N A P R A R G D E P Y R N I A G H L A G E C S P R T R G
40
I + + +A P R A R G D E P + C S P R T R G
5
I N S Y V A T R D A P R A R G D E P R Q T N R T S P T M R C S P R T R G
40
with 11 more sequence matches
Only the first 10 are displayed here.
25.0%
NZ_NVAU01000008.1:
Lanthipeptides: allorf_15089_15202_lanthipeptide
19
G D E P----Y R N I A G H L A G E C
34
G D P Y+N I +L A E C
6
G D T P F N T L Y K N I F I Y L A R E C
25
22.5%
NZ_DS999644.1 and 2 others:
NZ_LACR01000025.1 Lanthipeptides: YW5_RS27795_lanthipeptide NZ_ML123034.1 Lanthipeptides: EES43_RS16615_lanthipeptide
Lanthipeptides: SSGG_RS13165_lanthipeptide
11
S W N A P R A R G D E P Y R N I A G H L A G E C S P R T R G
40
+W + G L G C S T R G
2
T W A C A T V T L T V T V C S P T G T L C G S C S M G T R G
31
20.0%
NZ_BMTW01000001.1 and 1 other:
NZ_KZ268499.1 Lanthipeptides: CE422_RS19980_lanthipeptide
Lanthipeptides: IE134_RS03420_lanthipeptide
28
G H L A G E C S P R T R G
40
G L G C S T R G
19
G T L C G S C S M G T R G
31
19.0%
NZ_CP020563.1:
Lanthipeptides: allorf_2379503_2379736_lanthipeptide
13
N A P R A R G D E P Y R N I A G H L A G E C S P R T R G
40
P R R G P + S P R T R G
2
G G P R V R G G V P S S V G V S V I R A R W S P R T R G
29
17.5%
NZ_CP026498.1:
Lanthipeptides: allorf_09406948_09407160_lanthipeptide
25
N I A G H L A G E C S P R
37
N+A G G C P R
1
N V A G Q P L G G C E P R
13
17.5%
NZ_CP070496.1:
Lanthipeptides: allorf_3787434_3787580_lanthipeptide
34
C S P R T R G
40
C S P R T R G
10
C S P R T R G
16
17.5%
NZ_CP075175.1:
Lanthipeptides: KIK04_RS00230_lanthipeptide
12
W N A P R A R G D E P Y R N I A G H L A G E C
34
W N R G+ N G+C
5
W N C S R G C G N G N T A N T C V E T C G K C
27
15.7%
NZ_LIPG01000002.1 and 1 other:
NZ_LIPG01000002.1 Lanthipeptides: allorf_0371938_0372126_lanthipeptide
Lanthipeptides: allorf_0371938_0372126_lanthipeptide
22
P Y R N I A G H L A G E C S P R T
38
P R +G G C P R T
9
P G R Q G S G M R P G R C G P R T
25
15.0%
NZ_CP028721.1:
Lanthipeptides: allorf_32905_33036_lanthipeptide
4
S I Q V W Q C S W
12
S +V W C S W
1
S F R V W P C S W
9
14.8%
NZ_CP070496.1:
Lanthipeptides: allorf_3787495_3787722_lanthipeptide
14
A P R A R G D E P
22
A P R A R G D E P
8
A P R A R G D E P
16
allorf_3787427_3787648
Leader:
MVHAGCVKGAQGDITDTAPGA
Core:
E A H P R V R G E H S S D D A V T L Q P P G S S P R A R G A F T G E V A C D V A V G F I P A C A G S I P
Core with dehydrations:
E A H P R V R G E H Dha Dha D D A V Dhb L Q P P G Dha Dha P R A R G A F Dhb G E V A Cys D V A V G F I P A Cys A G Dha I P

#### antiSMASH-DB 4.0 matches for allorf_3787427_3787648

100.0%
NZ_CP070496.1:
Lanthipeptides: allorf_3787427_3787648_lanthipeptide
1
E A H P R V R G E H S S D D A V T L Q P P G S S P R A R G A F T G E V A C D V A V G F I P A C A G S I P
52
E A H P R V R G E H S S D D A V T L Q P P G S S P R A R G A F T G E V A C D V A V G F I P A C A G S I P
1
E A H P R V R G E H S S D D A V T L Q P P G S S P R A R G A F T G E V A C D V A V G F I P A C A G S I P
52
32.7%
NZ_CP070496.1:
Lanthipeptides: allorf_3786998_3787234_lanthipeptide
24
S P R A R G A F T G E V A C D V A V G F I P A C A G S I
51
S P R A R G A +G F I P A C A G S I
1
S P R A R G A L L W R C G S S P P L G F I P A C A G S I
28
29.3%
NZ_CP020563.1:
Lanthipeptides: allorf_2379503_2379736_lanthipeptide
4
P R V R G E H S S D D A V T L Q P P G S S P R A R G A F T G E V A C D V A V G F I P A C A G
49
P R V R G S V++ S P R R G + D + +P A A G
4
P R V R G G V P S S V G V S V I R A R W S P R T R G C S V V Q R H V D A G L L V V P A Y A G
49
with 11 more sequence matches
Only the first 10 are displayed here.
25.0%
NZ_RCOL01000001.1:
Lanthipeptides: allorf_2499994_2500137_lanthipeptide
22
G S S P R A R G A F T G E V A C D V A V G F I P A C A G S I
51
G P R A R G T + G P A C A G+
7
G P P P R A R G P R T R P W R A W S S P G T T P A C A G T T
36
19.2%
NZ_CP041604.2 and 2 others:
NZ_CP041610.2 Lanthipeptides: allorf_00762942_00763082_lanthipeptide NZ_CP041650.2 Lanthipeptides: allorf_01115746_01115886_lanthipeptide
Lanthipeptides: allorf_01200681_01200821_lanthipeptide
13
D D A V T L Q P P G S S P R A R G A F T G E V A C D
38
+ A+ + P G +P A R G +G A C
6
E G A L A R R S P G P A P P A R G R T S G S A A C S
31
19.2%
NZ_JACSPO010000013.1 and 1 other:
NZ_JACSPO010000013.1 Lanthipeptides: H9624_RS14865_lanthipeptide
Lanthipeptides: H9624_RS14865_lanthipeptide
19
Q P P G S S P R A R G A F T G E V A C D V A V G F I P A C
47
P P + P F G++A C V F C
27
S P P V A E P---A T F L G D L A C Q V L G D F F E K C
52
17.3%
NZ_CP041611.1 and 1 other:
NZ_CP041613.2 Lanthipeptides: allorf_01211048_01211164_lanthipeptide
Lanthipeptides: allorf_00812922_00813038_lanthipeptide
21
P G S S P R A R G A F T G E V A C D
38
P G +P A R G +G A C
6
P G P A P P A R G R T S G S A A C S
23
17.3%
NZ_CP070496.1:
Lanthipeptides: allorf_3786998_3787234_lanthipeptide
3
H P R V R G E H S S
12
H P R V R G E H+S
41
H P R V R G E H T S
50
17.3%
NZ_QGTL01000006.1:
Lanthipeptides: allorf_311998_312129_lanthipeptide
42
G F I P A C A G S I P
52
G I P A C A G S P
9
G L I P A C A G S T P
19
15.4%
NZ_CP034550.1:
Lanthipeptides: EKG83_RS30035_lanthipeptide
7
R G E H S S D D A V T L Q P P G S
23
G E + D V P P G S
4
N G E F A E G D I V A C N P P G S
20
15.4%
NZ_CP066762.1:
Lanthipeptides: JG536_RS12630_lanthipeptide
24
S P R A R G A F T G E V A C D V A V G F I P A
46
S P G A G + C + + +P A
21
S P N L I G A L I G A L L C F L L I E A L P A
43
15.4%
NZ_CP077652.1:
Lanthipeptides: allorf_2255880_2256005_lanthipeptide
3
H P R V R G E H S S
12
H P R R G+H S S
24
H P R S R G D H S S
33
15.4%
NZ_JANYMP010000013.1:
Lanthipeptides: NZH93_RS25860_lanthipeptide
8
G E H S S D D A V T L Q P P G S
23
G E + D V P P G S
6
G E F A E G D I V A C N P P G S
21

#### MIBiG 4.0 matches for allorf_3787427_3787648

7.7%
BGC0001155.5 (AGY49587.1):
Thiopeptide: GE2270
36
A C D V A V G F I P A C A
48
+C+ G F +C+
1
S C N C V C G F C C S C S
13
allorf_3787434_3787580
Leader:
MLPAHAGMNPTATSQATSPVNAPRARGDEPGG
Core:
W S V T A S S E L C S P R T R G
Core with dehydrations:
W Dha V Dhb A Dha Dha E L Cys Dha P R Dhb R G

#### antiSMASH-DB 4.0 matches for allorf_3787434_3787580

100.0%
NZ_CP070496.1:
Lanthipeptides: allorf_3787434_3787580_lanthipeptide
1
W S V T A S S E L C S P R T R G
16
W S V T A S S E L C S P R T R G
1
W S V T A S S E L C S P R T R G
16
35.0%
NZ_QGTL01000006.1:
Lanthipeptides: allorf_312083_312262_lanthipeptide
4
T A S S E L C S P R T R G
16
+A +C S P R R G
8
S A R R S V C S P R K R G
20
25.0%
NZ_QRBG01000006.1:
Lassopeptides: DWF04_RS10680_lassopeptide
1
W S V T A S S E L C S P R
13
W S+ A S + +P R
6
W S L D A S F P V D T P R
18
with 6 more sequence matches
21.9%
NZ_AP023392.1 and 4 others:
NZ_CP015557.1 Lanthipeptides: A6M16_RS04830_lanthipeptide NZ_CP065430.1 Lanthipeptides: I5V48_RS05980_lanthipeptide NZ_CP100430.1 Lanthipeptides: NLY76_RS04570_lanthipeptide NZ_JAEUXF010000003.1 Lanthipeptides: JNE40_RS02515_lanthipeptide
Lanthipeptides: H7679_RS04985_lanthipeptide
1
W S V T A S S E L C S P R T R
15
W+ T S E S P R
16
W A F T F S Y E C T S P N V R
30
20.0%
NZ_CP070496.1:
Lanthipeptides: allorf_3787129_3787275_lanthipeptide
9
L C S P R T R G
16
L C S P R T R G
33
L C S P R T R G
40
20.0%
NZ_CP070496.1:
Lanthipeptides: allorf_3787251_3787397_lanthipeptide
4
T A S S E L C S P R T R G
16
T+ + C S P R T R G
28
T S P T M R C S P R T R G
40
19.4%
NZ_VMLD01000009.1 and 3 others:
NZ_VMLI01000004.1 Lanthipeptides: HT696_RS02300_lanthipeptide NZ_VMMD01000015.1 Lanthipeptides: HT711_RS05565_lanthipeptide NZ_VMMI01000027.1 Lanthipeptides: HT721_RS06685_lanthipeptide
Lanthipeptides: HT679_RS04550_lanthipeptide
1
W S V T A S S E L C S P R T R
15
W+ T S E S P R
20
W A F T L S Y E C T S P N V R
34
17.5%
NZ_CP070496.1:
Lanthipeptides: allorf_3787373_3787519_lanthipeptide
10
C S P R T R G
16
C S P R T R G
34
C S P R T R G
40
12.9%
NZ_JAAXRC010000001.1:
Lanthipeptides: allorf_597683_597922_lanthipeptide
2
S V T A S S E L C S P R T R
15
V A S S E C P R
41
D V D A S S E F C R P A V R
54
allorf_3787495_3787722
Leader:
MLPAHAGMNPVAGA
Core:
S Q H H P N Y A P R A R G D E P L P P A R Y P L C L L G L L S R T P R G P F F L C G F G F V V V I P G R M R V A A G I C W
Core with dehydrations:
Dha Q H H P N Y A P R A R G D E P L P P A R Y P L Cys L L G L L Dha R Dhb P R G P F F L Cys G F G F V V V I P G R M R V A A G I Cys W

#### antiSMASH-DB 4.0 matches for allorf_3787495_3787722

100.0%
NZ_CP070496.1:
Lanthipeptides: allorf_3787495_3787722_lanthipeptide
1
S Q H H P N Y A P R A R G D E P L P P A R Y P L C L L G L L S R T P R G P F F L C G F G F V V V I P G R M R V A A G I C W
61
S Q H H P N Y A P R A R G D E P L P P A R Y P L C L L G L L S R T P R G P F F L C G F G F V V V I P G R M R V A A G I C W
1
S Q H H P N Y A P R A R G D E P L P P A R Y P L C L L G L L S R T P R G P F F L C G F G F V V V I P G R M R V A A G I C W
61
19.7%
NZ_BNCA01000011.1 and 1 other:
NZ_BNCA01000011.1 Lanthipeptides: allorf_144104_144280_lanthipeptide
Lanthipeptides: allorf_144104_144280_lanthipeptide
13
G D E P L P P A R Y P L C L L G L L S R T P R G P F F L C G F G
44
G P L P R Y P S R R P + G
1
G R Y P L P A T R Y P G V C R A R T S R R A R D P R K V T T Q G
32
16.4%
NZ_CP070496.1:
Lanthipeptides: allorf_3787251_3787397_lanthipeptide
8
A P R A R G D E P L P P A R
21
A P R A R G D E P R
14
A P R A R G D E P R Q T N R
27
with 5 more sequence matches
16.1%
NZ_AP014940.1:
Lanthipeptides: allorf_3261946_3262173_lanthipeptide
4
H P N Y A P R A R G D E P L P P A R Y P L C L L G L L S R
32
P R A R E +P P R+ G R
20
R P G R N A R A R I Q E A M P P E R W R W M R E G R A K R
48
16.1%
NZ_FNOG01000005.1:
Lanthipeptides: allorf_365504_365731_lanthipeptide
4
H P N Y A P R A R G D E P L P P A R Y P L C L L G L L S R
32
P R A R E +P P R+ G R
20
R P G R K A R A R I Q E A M P P E R W R W M R A G R A K R
48
14.8%
NZ_CP070496.1:
Lanthipeptides: allorf_3787373_3787519_lanthipeptide
8
A P R A R G D E P
16
A P R A R G D E P
14
A P R A R G D E P
22
14.8%
NZ_CP070496.1:
Lanthipeptides: allorf_3787129_3787275_lanthipeptide
8
A P R A R G D E P L
17
A P R A R G D E P+
14
A P R A R G D E P I
23
14.8%
NZ_KQ061217.1:
Lanthipeptides: allorf_2982148_2982333_lanthipeptide
36
G P F F L C G F G F V V V I P G R M R V A
56
G F F F V V+ R R+A
16
G E F F F G Y L A F V V I A F S R S R L A
36
allorf_3787556_3787777
Leader:
MLPAHAGMSLCPRRGIRYVSLGSFHAPRVDHFSCAGLDLWWLFRAGCGLPLASAGDVSLGG
Core:
S G A R S L P P G T C G
Core with dehydrations:
Dha G A R Dha L P P G Dhb Cys G

#### antiSMASH-DB 4.0 matches for allorf_3787556_3787777

100.0%
NZ_CP070496.1:
Lanthipeptides: allorf_3787556_3787777_lanthipeptide
1
S G A R S L P P G T C G
12
S G A R S L P P G T C G
1
S G A R S L P P G T C G
12
28.6%
NZ_QKUF01000009.1:
Lanthipeptides: allorf_200364_200519_lanthipeptide
3
A R S L P P G
9
R S L P P G
6
V R S L P P G
12
14.0%
NZ_CP023465.1:
Lanthipeptides: allorf_4131827_4132054_lanthipeptide
1
S G A R S L P P
8
S G A R S P P
13
S G A R S Q P P
20
allorf_3787768_3787845
Leader:
MRLRMSMGP
Core:
G V L R W G L H S V C T R W R W
Core with dehydrations:
G V L R W G L H Dha V Cys Dhb R W R W

#### antiSMASH-DB 4.0 matches for allorf_3787768_3787845

100.0%
NZ_CP070496.1:
Lanthipeptides: allorf_3787768_3787845_lanthipeptide
1
G V L R W G L H S V C T R W R W
16
G V L R W G L H S V C T R W R W
1
G V L R W G L H S V C T R W R W
16
35.0%
NZ_CP072384.1:
Lanthipeptides: allorf_0332557_0332658_lanthipeptide
6
G L H S V C T R W R
15
G S C T R W R
11
G A A S T C T R W R
20
25.0%
NZ_AP021901.1:
Lanthipeptides: allorf_0929005_0929109_lanthipeptide
10
V C T R W R W
16
C+R W R W
8
A C S R W R W
14
with 1 more sequence matches
20.8%
NZ_JHEG04000001.1:
Lanthipeptides: HC643_RS12630_lanthipeptide
3
L R W G L H S V C T R W R W
16
L W V C +W +
3
L G W S F A K V C V K W S F
16

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 24.03 out of 25.31
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.99 out of 20.97
Confidence: medium
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 19.86 out of 21.84
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.83 out of 23.79
Confidence: medium
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.17 out of 32.93
Confidence: medium
Additional weak hits (9):
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 19.86 out of 26.33
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 22.17 out of 30.11
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 22.17 out of 30.11
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.23 out of 33.73
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 19.42 out of 31.73
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 20.59 out of 30.97
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 18.70 out of 26.12
Confidence: weak
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.93 out of 27.55
Confidence: weak
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 15.37 out of 18.57
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

JQS30_RS16095 - Class II
  Cleavage pHMM score: -2.10
  RODEO score: 0
  Monoisotopic mass: 3083.3 Da
  Molecular weight: 3085.5 Da
  Number of bridges: 6
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3103.5 Da N = 1
    3121.6 Da N = 2
    3139.6 Da N = 3
    3157.6 Da N = 4
    3175.6 Da N = 5
    3193.6 Da N = 6
    3211.7 Da N = 7
allorf_3767835_3767960 - Class II
  Cleavage pHMM score: -3.40
  RODEO score: 0
  Monoisotopic mass: 3610.0 Da
  Molecular weight: 3612.1 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3630.1 Da N = 1
    3648.1 Da N = 2
    3666.2 Da N = 3
allorf_3767860_3768009 - Class II
  Cleavage pHMM score: -7.30
  RODEO score: 0
  Monoisotopic mass: 4105.1 Da
  Molecular weight: 4107.9 Da
  Number of bridges: 3
allorf_3770370_3770519 - Class II
  Cleavage pHMM score: -6.30
  RODEO score: 0
  Monoisotopic mass: 4208.3 Da
  Molecular weight: 4211.0 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4229.1 Da N = 1
    4247.1 Da N = 2
allorf_3770845_3770946 - Class II
  Cleavage pHMM score: -4.60
  RODEO score: 0
  Monoisotopic mass: 1618.7 Da
  Molecular weight: 1619.7 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1637.7 Da N = 1
    1655.7 Da N = 2
    1673.8 Da N = 3
    1691.8 Da N = 4
allorf_3773540_3773689 - Class II
  Cleavage pHMM score: -6.10
  RODEO score: 0
  Monoisotopic mass: 3934.9 Da
  Molecular weight: 3937.3 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3955.3 Da N = 1
    3973.3 Da N = 2
    3991.3 Da N = 3
    4009.4 Da N = 4
allorf_3773571_3773729 - Class II
  Cleavage pHMM score: -1.90
  RODEO score: 0
  Monoisotopic mass: 2856.6 Da
  Molecular weight: 2858.4 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2876.4 Da N = 1
    2894.4 Da N = 2
    2912.4 Da N = 3
    2930.5 Da N = 4
allorf_3774399_3774488 - Class II
  Cleavage pHMM score: -6.30
  RODEO score: 0
  Monoisotopic mass: 1986.2 Da
  Molecular weight: 1987.4 Da
  Number of bridges: 1
allorf_3783783_3783950 - Class II
  Cleavage pHMM score: -5.80
  RODEO score: 0
  Monoisotopic mass: 4974.5 Da
  Molecular weight: 4977.6 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4995.6 Da N = 1
    5013.7 Da N = 2
    5031.7 Da N = 3
    5049.7 Da N = 4
    5067.7 Da N = 5
    5085.7 Da N = 6
    5103.8 Da N = 7
allorf_3786763_3786897 - Class II
  Cleavage pHMM score: -5.80
  RODEO score: 0
  Monoisotopic mass: 2032.0 Da
  Molecular weight: 2033.3 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2051.3 Da N = 1
    2069.3 Da N = 2
    2087.3 Da N = 3
allorf_3786998_3787234 - Class II
  Cleavage pHMM score: -3.20
  RODEO score: 0
  Monoisotopic mass: 5166.7 Da
  Molecular weight: 5169.9 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    5188.0 Da N = 1
    5206.0 Da N = 2
    5224.0 Da N = 3
    5242.0 Da N = 4
    5260.0 Da N = 5
allorf_3787129_3787275 - Class II
  Cleavage pHMM score: -7.00
  RODEO score: 0
  Monoisotopic mass: 4491.5 Da
  Molecular weight: 4494.1 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4512.1 Da N = 1
    4530.1 Da N = 2
allorf_3787251_3787397 - Class II
  Cleavage pHMM score: -7.00
  RODEO score: 0
  Monoisotopic mass: 4426.3 Da
  Molecular weight: 4428.9 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4446.9 Da N = 1
    4464.9 Da N = 2
    4482.9 Da N = 3
    4500.9 Da N = 4
    4519.0 Da N = 5
    4537.0 Da N = 6
    4555.0 Da N = 7
allorf_3787373_3787519 - Class II
  Cleavage pHMM score: -7.00
  RODEO score: 0
  Monoisotopic mass: 4492.2 Da
  Molecular weight: 4494.9 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4513.0 Da N = 1
    4531.0 Da N = 2
allorf_3787427_3787648 - Class II
  Cleavage pHMM score: -3.30
  RODEO score: 0
  Monoisotopic mass: 5115.5 Da
  Molecular weight: 5118.6 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    5136.6 Da N = 1
    5154.6 Da N = 2
    5172.7 Da N = 3
    5190.7 Da N = 4
    5208.7 Da N = 5
allorf_3787434_3787580 - Class II
  Cleavage pHMM score: -3.80
  RODEO score: 0
  Monoisotopic mass: 1627.8 Da
  Molecular weight: 1628.8 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1646.8 Da N = 1
    1664.8 Da N = 2
    1682.8 Da N = 3
    1700.9 Da N = 4
    1718.9 Da N = 5
allorf_3787495_3787722 - Class II
  Cleavage pHMM score: -2.50
  RODEO score: 0
  Monoisotopic mass: 6674.5 Da
  Molecular weight: 6678.8 Da
  Number of bridges: 3
allorf_3787556_3787777 - Class II
  Cleavage pHMM score: -3.50
  RODEO score: 0
  Monoisotopic mass: 1047.5 Da
  Molecular weight: 1048.2 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1066.2 Da N = 1
    1084.2 Da N = 2
allorf_3787768_3787845 - Class II
  Cleavage pHMM score: -6.60
  RODEO score: 0
  Monoisotopic mass: 1975.0 Da
  Molecular weight: 1976.3 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1994.3 Da N = 1

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CatR | H2O2-responsive repressor
CcpA | Catabolite control protein A
IolR | Regulator of the inositol catabolism
LexA variant 3 | Repressor of DNA damage response
MexT | Global virulence regulator