GCF_015559285.1 - 6 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_JADMPO010000017.1 (Mediterraneibacter gnavus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 8.1	NRPS,cyclic-lactone-autoinducer	1	30,585

NZ_JADMPO010000001.1 (Mediterraneibacter gnavus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 11.1	lanthipeptide-class-ii	294,044	311,265

NZ_JADMPO010000023.1 (Mediterraneibacter gnavus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 15.1	terpene-precursor	1	20,339

NZ_JADMPO010000003.1 (Mediterraneibacter gnavus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 33.1	ranthipeptide,darobactin	226,474	248,068

NZ_JADMPO010000043.1 (Mediterraneibacter gnavus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 37.1	lanthipeptide-class-ii	1	11,375

NZ_JADMPO010000008.1 (Mediterraneibacter gnavus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 70.1	RRE-containing	39,495	60,454

Region	Type	From	To	Most similar known cluster
Region 8.1	NRPS,cyclic-lactone-autoinducer	1	30,585
Region 11.1	lanthipeptide-class-ii	294,044	311,265
Region 15.1	terpene-precursor	1	20,339
Region 33.1	ranthipeptide,darobactin	226,474	248,068
Region 37.1	lanthipeptide-class-ii	1	11,375
Region 70.1	RRE-containing	39,495	60,454

No secondary metabolite regions were found in these records:: NZ_JADMPO010000010.1 (Mediterraneibacter gnavus); NZ_JADMPO010000011.1 (Mediterraneibacter gnavus); NZ_JADMPO010000012.1 (Mediterraneibacter gnavus); NZ_JADMPO010000013.1 (Mediterraneibacter gnavus); NZ_JADMPO010000014.1 (Mediterraneibacter gnavus); NZ_JADMPO010000015.1 (Mediterraneibacter gnavus); NZ_JADMPO010000016.1 (Mediterraneibacter gnavus); NZ_JADMPO010000018.1 (Mediterraneibacter gnavus); NZ_JADMPO010000019.1 (Mediterraneibacter gnavus); NZ_JADMPO010000020.1 (Mediterraneibacter gnavus); NZ_JADMPO010000021.1 (Mediterraneibacter gnavus); NZ_JADMPO010000022.1 (Mediterraneibacter gnavus); NZ_JADMPO010000024.1 (Mediterraneibacter gnavus); NZ_JADMPO010000025.1 (Mediterraneibacter gnavus); NZ_JADMPO010000026.1 (Mediterraneibacter gnavus); NZ_JADMPO010000027.1 (Mediterraneibacter gnavus); NZ_JADMPO010000028.1 (Mediterraneibacter gnavus); NZ_JADMPO010000029.1 (Mediterraneibacter gnavus); NZ_JADMPO010000002.1 (Mediterraneibacter gnavus); NZ_JADMPO010000030.1 (Mediterraneibacter gnavus); NZ_JADMPO010000031.1 (Mediterraneibacter gnavus); NZ_JADMPO010000032.1 (Mediterraneibacter gnavus); NZ_JADMPO010000033.1 (Mediterraneibacter gnavus); NZ_JADMPO010000034.1 (Mediterraneibacter gnavus); NZ_JADMPO010000035.1 (Mediterraneibacter gnavus); NZ_JADMPO010000036.1 (Mediterraneibacter gnavus); NZ_JADMPO010000037.1 (Mediterraneibacter gnavus); NZ_JADMPO010000038.1 (Mediterraneibacter gnavus); NZ_JADMPO010000039.1 (Mediterraneibacter gnavus); NZ_JADMPO010000040.1 (Mediterraneibacter gnavus); NZ_JADMPO010000041.1 (Mediterraneibacter gnavus); NZ_JADMPO010000042.1 (Mediterraneibacter gnavus); NZ_JADMPO010000044.1 (Mediterraneibacter gnavus); NZ_JADMPO010000045.1 (Mediterraneibacter gnavus); NZ_JADMPO010000046.1 (Mediterraneibacter gnavus); NZ_JADMPO010000047.1 (Mediterraneibacter gnavus); NZ_JADMPO010000048.1 (Mediterraneibacter gnavus); NZ_JADMPO010000049.1 (Mediterraneibacter gnavus); NZ_JADMPO010000004.1 (Mediterraneibacter gnavus); NZ_JADMPO010000050.1 (Mediterraneibacter gnavus); NZ_JADMPO010000051.1 (Mediterraneibacter gnavus); NZ_JADMPO010000052.1 (Mediterraneibacter gnavus); NZ_JADMPO010000053.1 (Mediterraneibacter gnavus); NZ_JADMPO010000054.1 (Mediterraneibacter gnavus); NZ_JADMPO010000055.1 (Mediterraneibacter gnavus); NZ_JADMPO010000056.1 (Mediterraneibacter gnavus); NZ_JADMPO010000057.1 (Mediterraneibacter gnavus); NZ_JADMPO010000058.1 (Mediterraneibacter gnavus); NZ_JADMPO010000059.1 (Mediterraneibacter gnavus); NZ_JADMPO010000005.1 (Mediterraneibacter gnavus); NZ_JADMPO010000060.1 (Mediterraneibacter gnavus); NZ_JADMPO010000061.1 (Mediterraneibacter gnavus); NZ_JADMPO010000062.1 (Mediterraneibacter gnavus); NZ_JADMPO010000063.1 (Mediterraneibacter gnavus); NZ_JADMPO010000064.1 (Mediterraneibacter gnavus); NZ_JADMPO010000065.1 (Mediterraneibacter gnavus); NZ_JADMPO010000066.1 (Mediterraneibacter gnavus); NZ_JADMPO010000067.1 (Mediterraneibacter gnavus); NZ_JADMPO010000068.1 (Mediterraneibacter gnavus); NZ_JADMPO010000069.1 (Mediterraneibacter gnavus); NZ_JADMPO010000006.1 (Mediterraneibacter gnavus); NZ_JADMPO010000070.1 (Mediterraneibacter gnavus); NZ_JADMPO010000071.1 (Mediterraneibacter gnavus); NZ_JADMPO010000007.1 (Mediterraneibacter gnavus); NZ_JADMPO010000009.1 (Mediterraneibacter gnavus)

Compact view

NZ_JADMPO010000017.1 - Region 1 - NRPS,cyclic-lactone-autoinducer

Download region GenBank file

Download region SVG

Location: 1 - 30,585 nt. (total: 30,585 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: PPTase

I2I27_RS12715: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: esterase

I2I27_RS12720: thioesterase

smcogs: SMCOG1004: thioesterase

Ligases: ligase

I2I27_RS12700: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

I2I27_RS12705: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

I2I27_RS12710: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001128.4	0.61	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.59	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002286.3	0.59	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.4	0.59	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.59	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.59	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001261.3	0.58	NRPS	AM-toxin	Alternaria alternata
BGC0002135.2	0.57	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001251.4	0.57	NRPS	epichloenin A	Epichloe festucae
BGC0000357.5	0.57	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001128.4	0.64	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.63	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002286.3	0.63	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.4	0.63	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.63	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.63	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001261.3	0.63	NRPS	AM-toxin	Alternaria alternata
BGC0002135.2	0.62	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001251.4	0.62	NRPS	epichloenin A	Epichloe festucae
BGC0000357.5	0.62	NRPS	cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val)	Penicillium rubens Wisconsin 54-1255

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.72 out of 27.78

Confidence: medium

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 30585:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Cys) + (Me-Cys)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

I2I27_RS12700: Cys

Search NORINE for peptide: strict or relaxed

AMP-binding (531..926): Cys

nrpys: Cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: TNIAFDLSVYDGNSLLSGDVSLGGATEASIWSIY
Nearest Stachelhaus code(s):: Cys DLYNLSLIWK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

I2I27_RS12705: Cys

Search NORINE for peptide: strict or relaxed

AMP-binding (547..945): Cys

nrpys: Cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: TEVSFDLSVYDGNSILSGDLAMGGATEAAIWSNF
Nearest Stachelhaus code(s):: Cys DLYNMSMIWK (85% 8Å match)
Stachelhaus code match:: 90% (moderate)

I2I27_RS12710: X

AMP-binding (22..421): X

nrpys: diOH-Bz, Sal

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: HCYLFALYSPGNGIIIGGAHIGYGATEGIIMYNA
Nearest Stachelhaus code(s):: Sal ALPGQGVLNK (41% 8Å match)
Stachelhaus code match:: 60% (weak)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria

NZ_JADMPO010000001.1 - Region 1 - lanthipeptide-class-ii

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Location: 294,044 - 311,265 nt. (total: 17,222 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: protease

I2I27_RS01375: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase

I2I27_RS01385: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.59	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000500.5	0.58	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0001210.5	0.51	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0002698.2	0.47	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0001407.5	0.46	ribosomal	bicereucin	Bacillus cereus SJ1
BGC0000527.5	0.46	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000516.4	0.46	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000502.5	0.45	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0000539.5	0.44	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0002699.2	0.44	ribosomal	nostolysamide A, nostolysamide B	Nostoc punctiforme PCC 73102

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.59	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000500.5	0.58	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0001210.5	0.51	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0002698.2	0.47	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0001407.5	0.46	ribosomal	bicereucin	Bacillus cereus SJ1
BGC0000527.5	0.46	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000516.4	0.46	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000502.5	0.45	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0000539.5	0.44	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0002699.2	0.44	ribosomal	nostolysamide A, nostolysamide B	Nostoc punctiforme PCC 73102

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for I2I27_RS01385

I2I27_RS01380

Leader:

MKEKNIKEKHLECEVPEKEHYGKKFEDLTPEEMERIQGG

Core:

GDVIPEELTKSLGMILSINGYKC

Core with dehydrations:

GDVIPEELDhbKDhaLGMILDhaINGYKCys

antiSMASH-DB 4.0 matches for I2I27_RS01380

100.0%

NZ_JADMPO010000001.1:

Lanthipeptides: I2I27_RS01380_lanthipeptide

GDVIPEELTKSLGMILSINGYKC

38.7%

NZ_JQBU01000033.1and 1 other:

NZ_JQBV01000009.1 Lanthipeptides: IV76_RS12120_lanthipeptide

Lanthipeptides: IV75_RS14620_lanthipeptide

GDVIPEE---------LTKSLGMILSINGYKC

GDV+PE L S+G++ +I G KC

GDVMPESTPICAGFATLMSSIGLVKTIKG-KC

33.3%

NZ_FUXI01000002.1:

Lanthipeptides: B5D30_RS01240_lanthipeptide

GDVIPEELTKSLGMILSINGYKC

GDV P+ + + S YKC

GDVNPQTVGSLWEFLTSKGEYKC

with 6 more sequence matches

26.9%

NZ_JACSMH010000008.1and 2 others:

NZ_JACSMX010000006.1 Lanthipeptides: KNQ03_RS15615_lanthipeptideNZ_JACSMZ010000005.1 Lanthipeptides: KNQ06_RS16025_lanthipeptide

Lanthipeptides: KNP89_RS14470_lanthipeptide

GDVIPEELTKSLGMILSIN

GDV PE +G+I+ +

GDVQPETTPFCVGVIVGVT

25.0%

NC_018499.1and 40 others:

NC_018499.1 Lanthipeptides: BCK_RS27855_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27850_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27860_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27855_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27850_lanthipeptideNZ_CP015591.1 Lanthipeptides: A7A70_RS27565_lanthipeptideNZ_CP015591.1 Lanthipeptides: A7A70_RS27560_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27215_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27210_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27215_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27210_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29375_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29370_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29365_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29955_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29950_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29945_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29955_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29950_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29945_lanthipeptideNZ_JACYOF010000027.1 Lanthipeptides: IGI01_RS29005_lanthipeptideNZ_JANIOB010000033.1 Lanthipeptides: NQ113_RS28005_lanthipeptideNZ_JAOPQW010000026.1 Lanthipeptides: OCD10_RS25275_lanthipeptideNZ_JAOPQW010000026.1 Lanthipeptides: OCD10_RS25270_lanthipeptideNZ_JH791925.1 Lanthipeptides: IE3_RS28545_lanthipeptideNZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27570_lanthipeptideNZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27565_lanthipeptideNZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27560_lanthipeptideNZ_NUBO01000052.1 Lanthipeptides: CN575_RS29780_lanthipeptideNZ_NUML01000015.1 Lanthipeptides: COD66_RS20150_lanthipeptideNZ_NUML01000015.1 Lanthipeptides: COD66_RS20145_lanthipeptideNZ_NUVR01000040.1 Lanthipeptides: COI88_RS26655_lanthipeptideNZ_NUVR01000040.1 Lanthipeptides: COI88_RS26650_lanthipeptideNZ_NVJC01000007.1 Lanthipeptides: COM38_RS07400_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23035_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23030_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23025_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23035_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23030_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23025_lanthipeptide

Lanthipeptides: BCK_RS27860_lanthipeptide

GDVIPEELTKSLG

GDV PE L+ LG

GDVTPEGLSSWLG

25.0%

NZ_CP033919.1:

Lanthipeptides: EG347_RS22885_lanthipeptide

VIPEELTKSLGMILSINGYKC

VI ++ KSL I + Y C

VIDQDTPKSLSCIATSCNYPC

19.4%

NZ_CP102973.1and 1 other:

NZ_FQQG01000014.1 Lanthipeptides: BT790_RS14420_lanthipeptide

Lanthipeptides: NW963_RS14100_lanthipeptide

GDVIPEELT

GDV PE T

GDVTPESTT

18.8%

NZ_CP036019.1and 9 others:

NZ_CP036019.1 Lanthipeptides: EXW52_RS27205_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27190_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27180_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27175_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27170_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27190_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27180_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27175_lanthipeptideNZ_CP036019.1 Lanthipeptides: EXW52_RS27170_lanthipeptide

Lanthipeptides: EXW52_RS27205_lanthipeptide

GDVIPEELTKSLGMILSIN

GDV PE + ++++I+

GDVSPETTPATPTIVVAIS

18.2%

NZ_RSCJ01000051.1:

Lanthipeptides: PCC6912_RS34970_lanthipeptide

VIPEELTKSLGMILS

V+PE+L K++ ++S

VVPEDLVKAIAQVMS

I2I27_RS01390

Leader:

MMKDNKKELNVITGVAFDDMSIDEMAEVQGA

Core:

GDVEGEVTTPICAVAVTASLSIQVAKTLKGKC

Core with dehydrations:

GDVEGEVDhbDhbPICysAVAVDhbADhaLDhaIQVAKDhbLKGKCys

antiSMASH-DB 4.0 matches for I2I27_RS01390

100.0%

NZ_JADMPO010000001.1:

Lanthipeptides: I2I27_RS01390_lanthipeptide

GDVEGEVTTPICAVAVTASLSIQVAKTLKGKC

56.2%

NZ_FUXI01000002.1:

Lanthipeptides: B5D30_RS01205_lanthipeptide

GDVEGEVTTPICAVAVTASLSIQVAKTLKGKC

GDV E TT +CAV TA +IQV +T+K KC

GDVNTE-TTTVCAVFATACGAIQVVRTIKKKC

56.2%

NZ_JQBU01000033.1and 1 other:

NZ_JQBV01000009.1 Lanthipeptides: IV76_RS12120_lanthipeptide

Lanthipeptides: IV75_RS14620_lanthipeptide

GDVEGEVTTPICAVAVTASLSIQVAKTLKGKC

GDV E +TPICA T SI + KT+KGKC

GDVMPE-STPICAGFATLMSSIGLVKTIKGKC

with 45 more sequence matches

Only the first 10 are displayed here.

53.1%

NZ_CP102973.1and 1 other:

NZ_FQQG01000014.1 Lanthipeptides: BT790_RS14420_lanthipeptide

Lanthipeptides: NW963_RS14100_lanthipeptide

GDVEGEVTTPICAVAVTASLSIQVAKTLKGKC

GDV E TT +CA + + SIQ+ KTLK KC

GDVTPESTT-VCAAFASFAGSIQLVKTLKSKC

50.0%

NZ_CP086395.1and 1 other:

NZ_JAKTAW010000012.1 Lanthipeptides: MKK30_RS11185_lanthipeptide

Lanthipeptides: LMK00_RS10670_lanthipeptide

GDVEGEVTTPICAVAVTASLSIQVAKTLKGKC

GDVE +TPIC ++SI + KTLKG+C

GDVEVR-STPICTFTAGVTVSIVIVKTLKGRC

50.0%

NZ_CP091282.1:

Lanthipeptides: L2Z53_RS12190_lanthipeptide

GDVEGEVTTP-------ICAVAVTASLSIQVAKTLKGKC

GDV E TTP + +V LSI VAKT+KGKC

GDVNVE-TTPTATISAFLLSVGGGYELSIHVAKTVKGKC

50.0%

NZ_JADNGS010000002.1:

Lanthipeptides: I2D92_RS06840_lanthipeptide

GDVEGEVTTPICAV----AVTASLSIQVAKTLKGKC

GD+E T AV A T S SI V KT+KGKC

GDIEPNSLTVASAVLMSAAATGSFSIAVTKTVKGKC

50.0%

NZ_SDJV01000024.1:

Lanthipeptides: ES032_RS12700_lanthipeptide

GDVEGEVTTPICAVAVTASLSIQVAKTLKGKC

GDV+ E TTP CA + +S V KT+KG C

GDVQVE-TTPACAFTASILVSYGVVKTIKGHC

47.5%

NZ_JAQCQD010000003.1:

Lanthipeptides: PGZ38_RS05480_lanthipeptide

GDVEGEVTTPICAV---------AVTASLSIQVAKTLKGKC

GD+ E TTP CA+ AV+ S+ V KTLKGKC

GDISPE-TTPACALIISKIISGAAVSFGFSVSVVKTLKGKC

45.0%

NZ_QSIO01000003.1:

Lanthipeptides: DW820_RS07295_lanthipeptide

GDVEGEVTTPICAV---------AVTASLSIQVAKTLKGKC

GD+ E TTP C + AV+ S+ V KTLKGKC

GDISPE-TTPACVLIISNVISGAAVSFKFSVDVVKTLKGKC

43.8%

NZ_JAQDYA010000001.1:

Lanthipeptides: PGT72_RS00020_lanthipeptide

GDVEGEVTTPICAVAVTASLSIQVAKTLKGKC

GD+ E +TP+CA T + I + KT+KG C

GDITPE-STPVCAAFATLASGIALVKTIKGNC

42.5%

NZ_JAFHCX010000012.1and 1 other:

NZ_LR738722.1 Lanthipeptides: STREPSUIS_RS04075_lanthipeptide

Lanthipeptides: JXW96_RS06965_lanthipeptide

GDVEGEVTTPICAV---------AVTASLSIQVAKTLKGKC

GD+ E TTP CA+ AV+ + S+ V KT+KG C

GDISPE-TTPACALIISKAISGAAVSFAFSVGVVKTVKGNC

40.6%

NZ_JAFLVY010000007.1:

Lanthipeptides: JZO73_RS03920_lanthipeptide

GDVEGEVTTPICAVAVTASLSIQVAKTLKGKC

GDV E + + T + SI + KTLKG C

GDVNPE---SVASFFATLASSIALVKTLKGHC

allorf_303591_303701

Leader:

MLGLALIHETSYGG

Core:

IRYEKRQTLKNYNPYTCFYKII

Core with dehydrations:

IRYEKRQDhbLKNYNPYDhbCysFYKII

antiSMASH-DB 4.0 matches for allorf_303591_303701

100.0%

NZ_JADMPO010000001.1:

Lanthipeptides: allorf_303591_303701_lanthipeptide

IRYEKRQTLKNYNPYTCFYKII

22.7%

NZ_JAEQNB010000006.1:

Lanthipeptides: JJB07_RS18745_lanthipeptide

NYNPYTCFYKII

+++ YTCF +I

SWSEYTCFCSLI

allorf_303731_303931

Leader:

MRNRIITGFRNMAAS

Core:

IYNSDISIPISNLFCSPPPGCYLPCSKITLFKNIYCKMKYNHNKMKKIFDI

Core with dehydrations:

IYNDhaDIDhaIPIDhaNLFCysDhaPPPGCysYLPCysDhaKIDhbLFKNIYCysKMKYNHNKMKKIFDI

antiSMASH-DB 4.0 matches for allorf_303731_303931

100.0%

NZ_JADMPO010000001.1:

Lanthipeptides: allorf_303731_303931_lanthipeptide

IYNSDISIPISNLFCSPPPGCYLPCSKITLFKNIYCKMKYNHNKMKKIFDI

13.7%

NZ_CP084530.1and 1 other:

NZ_CP084530.1 Lanthipeptides: allorf_0461347_0461490_lanthipeptide

Lanthipeptides: allorf_0461347_0461490_lanthipeptide

IPISNLFCSPP

IPIS C+PP

IPISESICTPP

13.2%

NZ_CP011130.1and 2 others:

NZ_CP023465.1 Lanthipeptides: allorf_4124021_4124236_lanthipeptideNZ_KQ061217.1 Lanthipeptides: allorf_2970820_2971035_lanthipeptide

Lanthipeptides: allorf_4082202_4082426_lanthipeptide

SDISIPISNLFCSPPPGC

S I +S P PGC

SRIRAGVSTTAAKPAPGC

with 3 more sequence matches

11.8%

NZ_FMCR01000002.1:

Lanthipeptides: allorf_0951186_0951290_lanthipeptide

CSPPPGCYLPCSKITLFKNIY

CSP P + T F+ +

CSPVPAAMARLGRRTAFRRAW

11.8%

NZ_KB905395.1and 1 other:

NZ_KB905395.1 Lanthipeptides: allorf_13012_13248_lanthipeptide

Lanthipeptides: allorf_13012_13248_lanthipeptide

DISIPISNLFCSPPPGCYLPC

+ ++P++ L C+ GC C

ESAVPLAKLGCNTSDGCGHTC

11.8%

NZ_SLXA01000002.1:

Lanthipeptides: allorf_029229_029357_lanthipeptide

FCSPPPGCYL

+CS P GC+L

YCSWPTGCFL

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.38 out of 27.78

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.55 out of 19.26

Confidence: medium

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.81 out of 28.14

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.99 out of 30.25

Confidence: medium

Additional weak hits (6):

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.30 out of 39.62

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 18.58 out of 30.11

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 18.84 out of 30.11

Confidence: weak

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.08 out of 20.47

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 22.66 out of 26.12

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.94 out of 36.54

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

I2I27_RS01380 - Class II

Cleavage pHMM score: 2.10

RODEO score: 0

Monoisotopic mass: 2425.3 Da

Molecular weight: 2426.8 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2444.9 Da N = 1; 2462.9 Da N = 2

I2I27_RS01390 - Class II

Cleavage pHMM score: 3.10

RODEO score: 0

Monoisotopic mass: 3079.7 Da

Molecular weight: 3081.6 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3099.6 Da N = 1; 3117.6 Da N = 2; 3135.6 Da N = 3; 3153.7 Da N = 4

allorf_303591_303701 - Class II

Cleavage pHMM score: -1.10

RODEO score: 0

Monoisotopic mass: 2817.5 Da

Molecular weight: 2819.3 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2837.3 Da N = 1

allorf_303731_303931 - Class II

Cleavage pHMM score: -6.40

RODEO score: 0

Monoisotopic mass: 5834.0 Da

Molecular weight: 5838.0 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 5856.0 Da N = 1; 5874.0 Da N = 2

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
PerR	Peroxide regulator

NZ_JADMPO010000023.1 - Region 1 - terpene-precursor

Download region GenBank file

Download region SVG

Location: 1 - 20,339 nt. (total: 20,339 nt) Show pHMM detection rules used

Region on contig edge.

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: glycosyltransferase

I2I27_RS14460: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

Hydrolases: back translocase

I2I27_RS14395: GTP-binding protein LepA

smcogs: SMCOG1190: GTP-binding protein LepA

Ligases: synthase synthetase

I2I27_RS14420: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

I2I27_RS14425: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0001456.3	0.38	terpene	isorenieratene	Streptomyces argillaceus
BGC0001605.3	0.38	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0000665.5	0.37	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0000633.3	0.37	terpene	carotenoid	Streptomyces avermitilis
BGC0001227.3	0.36	terpene	isorenieratene	Streptomyces collinus Tu 365

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0001456.3	0.38	terpene	isorenieratene	Streptomyces argillaceus
BGC0001605.3	0.38	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0000665.5	0.37	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0000633.3	0.37	terpene	carotenoid	Streptomyces avermitilis
BGC0001227.3	0.36	terpene	isorenieratene	Streptomyces collinus Tu 365

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

I2I27_RS14420: PT_FPPS_like

Domain 1 (32 - 295): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: IPP, DMAPP → FPP

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.54 out of 18.46

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.61 out of 20.97

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.96 out of 23.79

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.87 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.85 out of 28.19

Confidence: medium

Additional weak hits (4):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.57 out of 26.06

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.91 out of 31.73

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 21.71 out of 33.73

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.40 out of 33.14

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
IolR	Regulator of the inositol catabolism
RpoN	Regulator of nitrogen assimilation and virulence
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_JADMPO010000003.1 - Region 1 - darobactin,ranthipeptide

Download region GenBank file

Download region SVG

Location: 226,474 - 248,068 nt. (total: 21,595 nt) Show pHMM detection rules used

Region on contig edge.

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))
darobactin: ((cds(PF04055 and (TIGR04085 or SPASM)) and darobactin_precursor) or darobactin_rSAM)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	ranthipeptide	darobactin	Similarity score	Type	Compound(s)	Organism
BGC0002306.2			0.32	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842

Reference	Aggregated	Similarity score	Type	Compound(s)	Organism
BGC0002306.2		0.47	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.50 out of 27.78

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.40 out of 27.55

Confidence: medium

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.94 out of 21.55

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.05 out of 27.78

Confidence: medium

Additional weak hits (3):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.56 out of 26.06

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.55 out of 30.25

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 23.91 out of 30.98

Confidence: weak

RREFinder

TFBS Finder

RRE predictions

: RRE type: Ranthipeptide_rSAM_RRE; Location: 0 - 111; Score: 90.4
: RRE type: Ranthipeptide_rSAM_RRE; Location: 0 - 111; Score: 90.4

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM	Regulator of nitrogen-fixation genes

NZ_JADMPO010000043.1 - Region 1 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 1 - 11,375 nt. (total: 11,375 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

I2I27_RS16800: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000525.5	0.44	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000554.4	0.42	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002704.2	0.41	ribosomal	archalan β	Halorussus salinus
BGC0001210.5	0.36	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0002699.2	0.35	ribosomal	nostolysamide A, nostolysamide B	Nostoc punctiforme PCC 73102
BGC0000539.5	0.35	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0000516.4	0.35	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000527.5	0.34	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000517.4	0.33	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0001407.5	0.32	ribosomal	bicereucin	Bacillus cereus SJ1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000525.5	0.44	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000554.4	0.42	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002704.2	0.41	ribosomal	archalan β	Halorussus salinus
BGC0001210.5	0.36	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0002699.2	0.35	ribosomal	nostolysamide A, nostolysamide B	Nostoc punctiforme PCC 73102
BGC0000539.5	0.35	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0000516.4	0.35	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000527.5	0.34	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0000517.4	0.33	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0001407.5	0.32	ribosomal	bicereucin	Bacillus cereus SJ1

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for I2I27_RS16800

I2I27_RS16805

Leader:

MADSRVLEMYAGNLLEEMQEIEKM

Core:

IPGDQENEIVSSHTVGCSAFLTIYCC

Core with dehydrations:

IPGDQENEIVDhaDhaHDhbVGCysDhaAFLDhbIYCysCys

antiSMASH-DB 4.0 matches for I2I27_RS16805

100.0%

NZ_CP070036.1and 2 others:

NZ_JADMPO010000043.1 Lanthipeptides: I2I27_RS16805_lanthipeptideNZ_JAQMLK010000037.1 Lanthipeptides: PNW18_RS16660_lanthipeptide

Lanthipeptides: I6K72_RS03970_lanthipeptide

IPGDQENEIVSSHTVGCSAFLTIYCC

96.2%

NZ_JADNGF010000061.1:

Lanthipeptides: I2E06_RS15650_lanthipeptide

IPGDQENEIVSSHTVGCSAFLTIYCC

IP DQENEIVSSHTVGCSAFLTIYCC

IPEDQENEIVSSHTVGCSAFLTIYCC

60.5%

NZ_CYZG01000001.1:

Lanthipeptides: ARA00_RS15445_lanthipeptide

IPGDQENEIVSSHTVGCSAFLTIYCC

IP DQENE+VSSHTVGC AFLTIYCC

IPEDQENELVSSHTVGCGAFLTIYCC

with 26 more sequence matches

Only the first 10 are displayed here.

42.3%

NZ_WWSD01000018.1:

Lanthipeptides: GT593_RS11715_lanthipeptide

SHTVGCSAFLTIYCC

+HT+GC+A LTIYCC

THTIGCAALLTIYCC

38.5%

NZ_CP036170.1:

Lanthipeptides: HDCHBGLK_RS18795_lanthipeptide

SHTVGCSAFLTIYCC

S T+ C FLTIYCC

STTIKCGTFLTIYCC

34.6%

NZ_SPFR01000005.1:

Lanthipeptides: FGQ83_RS17540_lanthipeptide

SHTVGCSAFLTIYCC

+ T GCS F TI CC

TWTKGCSQFCTIICC

30.8%

NZ_CP015849.1:

Lanthipeptides: A8713_RS33905_lanthipeptide

SSHTVGCSAFLTIYCC

++ TVGCS TI C

AASTVGCSGLCTIIVC

28.2%

NZ_QGDL01000005.1:

Lanthipeptides: A8806_RS26140_lanthipeptide

EIVSSHTVGCSAFLTIYCC

E + ++TVGCS TIYCC

EQIFTNTVGCSNLFTIYCC

28.2%

NZ_SLXA01000002.1:

Lanthipeptides: EV212_RS13395_lanthipeptide

EIVSSHTVGCSAFLTIYCC

E S +V CS LTIYCC

EQKDSFSVECSPILTIYCC

26.9%

NZ_CP036071.1:

Lanthipeptides: allorf_19132_19248_lanthipeptide

SSHTVGCSAFLT

S + VGCS+FL+

SFYFVGCSSFLS

26.9%

NZ_CP048607.1:

Lanthipeptides: allorf_4196740_4196883_lanthipeptide

IVSSHTVGCSAFL

IV T+GC+A L

IVECGTIGCTAIL

26.9%

NZ_CP102267.1and 2 others:

NZ_JADMOE010000006.1 Lanthipeptides: I2G55_RS05425_lanthipeptideNZ_LT635469.1 Lanthipeptides: BQ7352_RS14540_lanthipeptide

Lanthipeptides: NQ550_RS10225_lanthipeptide

SAFLTIYCC

S+FLTI CC

SSFLTIVCC

26.9%

NZ_CP113781.1:

Lanthipeptides: GGADHKLB_RS14125_lanthipeptide

VGCSAFLTIYCC

+ C+ FLTI CC

LNCTHFLTILCC

I2I27_RS16845

Leader:

MDQFVKQVLEEEKFSQEQKSYLLDCLEQGEEMEEVLYL

Core:

AKSCLSVEQMERIKQLLSEHSQMFRCSWRKSWNKKKRDKEG

Core with dehydrations:

AKDhaCysLDhaVEQMERIKQLLDhaEHDhaQMFRCysDhaWRKDhaWNKKKRDKEG

antiSMASH-DB 4.0 matches for I2I27_RS16845

100.0%

NZ_CP070036.1and 2 others:

NZ_JADMPO010000043.1 Lanthipeptides: I2I27_RS16845_lanthipeptideNZ_JAQMLK010000037.1 Lanthipeptides: PNW18_RS16700_lanthipeptide

Lanthipeptides: I6K72_RS03930_lanthipeptide

AKSCLSVEQMERIKQLLSEHSQMFRCSWRKSWNKKKRDKEG

24.4%

NZ_CP039297.1and 3 others:

NZ_CP040672.1 Lanthipeptides: allorf_1096518_1096664_lanthipeptideNZ_CP059318.1 Lanthipeptides: allorf_0101519_0101665_lanthipeptideNZ_CP087137.1 Lanthipeptides: allorf_0101357_0101503_lanthipeptide

Lanthipeptides: allorf_0101584_0101730_lanthipeptide

MERIKQLLS-EHSQMFRCSWRKSW

M R Q LS H RC W+ +W

MLRCFQHLSRPHIATQRCPWQNNW

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (3):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.59 out of 31.73

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.12 out of 33.14

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.96 out of 27.04

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

I2I27_RS16805 - Class II

Cleavage pHMM score: -5.20

RODEO score: 0

Monoisotopic mass: 2695.2 Da

Molecular weight: 2697.0 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2715.0 Da N = 1; 2733.0 Da N = 2

I2I27_RS16845 - Class II

Cleavage pHMM score: -4.10

RODEO score: 0

Monoisotopic mass: 4886.5 Da

Molecular weight: 4889.6 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 4907.7 Da N = 1; 4925.7 Da N = 2; 4943.7 Da N = 3; 4961.7 Da N = 4

TFBS definitions

Regulator	Description

NZ_JADMPO010000008.1 - Region 1 - RRE-containing

Download region GenBank file

Download region SVG

Location: 39,495 - 60,454 nt. (total: 20,960 nt) Show pHMM detection rules used

RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002306.2	0.61	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000599.5	0.38	ribosomal	thuricin CD α, thuricin CD β	Bacillus thuringiensis
BGC0001210.5	0.37	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000626.3	0.37	ribosomal	thuricin	Bacillus thuringiensis
BGC0000521.3	0.36	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000539.5	0.36	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0002323.2	0.34	ribosomal	nisin J	Staphylococcus capitis
BGC0001618.3	0.34	ribosomal	hyicin 3682	Staphylococcus hyicus
BGC0000542.3	0.34	ribosomal	paenicidin B	Paenibacillus terrae
BGC0001779.5	0.34	ribosomal	siamycin	Streptomyces nodosus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002306.2	0.61	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000599.5	0.38	ribosomal	thuricin CD α, thuricin CD β	Bacillus thuringiensis
BGC0001210.5	0.37	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000626.3	0.37	ribosomal	thuricin	Bacillus thuringiensis
BGC0000521.3	0.36	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000539.5	0.36	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0002323.2	0.34	ribosomal	nisin J	Staphylococcus capitis
BGC0001618.3	0.34	ribosomal	hyicin 3682	Staphylococcus hyicus
BGC0000542.3	0.34	ribosomal	paenicidin B	Paenibacillus terrae
BGC0001779.5	0.34	ribosomal	siamycin	Streptomyces nodosus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.58 out of 21.84

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 22.97 out of 24.78

Confidence: strong

Additional weak hits (1):

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.75 out of 39.62

Confidence: weak

RREFinder

TFBS Finder

RRE predictions

: RRE type: Other_Sactipeptide_rSAM_RRE; Location: 4 - 118; Score: 44.6

TFBS definitions

Regulator	Description
LexA variant 2	Repressor of DNA damage response
MexT	Global virulence regulator