Select genomic region:
Overview
8.1
11.1
15.1
33.1
37.1
70.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_JADMPO010000017.1 (Mediterraneibacter gnavus)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 8.1 | NRPS,cyclic-lactone-autoinducer | 1 | 30,585 |

NZ_JADMPO010000001.1 (Mediterraneibacter gnavus)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 11.1 | lanthipeptide-class-ii | 294,044 | 311,265 |

NZ_JADMPO010000023.1 (Mediterraneibacter gnavus)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 15.1 | terpene-precursor | 1 | 20,339 |

NZ_JADMPO010000003.1 (Mediterraneibacter gnavus)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 33.1 | ranthipeptide,darobactin | 226,474 | 248,068 |

NZ_JADMPO010000043.1 (Mediterraneibacter gnavus)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 37.1 | lanthipeptide-class-ii | 1 | 11,375 |

NZ_JADMPO010000008.1 (Mediterraneibacter gnavus)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 70.1 | RRE-containing | 39,495 | 60,454 |

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 8.1 | NRPS,cyclic-lactone-autoinducer | 1 | 30,585 |
Region 11.1 | lanthipeptide-class-ii | 294,044 | 311,265 |
Region 15.1 | terpene-precursor | 1 | 20,339 |
Region 33.1 | ranthipeptide,darobactin | 226,474 | 248,068 |
Region 37.1 | lanthipeptide-class-ii | 1 | 11,375 |
Region 70.1 | RRE-containing | 39,495 | 60,454 |

No secondary metabolite regions were found in these records:
  NZ_JADMPO010000010.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000011.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000012.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000013.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000014.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000015.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000016.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000018.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000019.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000020.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000021.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000022.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000024.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000025.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000026.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000027.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000028.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000029.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000002.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000030.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000031.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000032.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000033.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000034.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000035.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000036.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000037.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000038.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000039.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000040.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000041.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000042.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000044.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000045.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000046.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000047.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000048.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000049.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000004.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000050.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000051.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000052.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000053.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000054.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000055.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000056.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000057.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000058.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000059.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000005.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000060.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000061.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000062.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000063.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000064.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000065.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000066.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000067.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000068.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000069.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000006.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000070.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000071.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000007.1 (Mediterraneibacter gnavus)
  NZ_JADMPO010000009.1 (Mediterraneibacter gnavus)

Compact view
NZ_JADMPO010000017.1 - Region 1 - NRPS,cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 30,585 nt. (total: 30,585 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: PPTase
I2I27_RS12715: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: esterase
I2I27_RS12720: thioesterase

smcogs
  SMCOG1004: thioesterase

Ligases: ligase
I2I27_RS12700: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

I2I27_RS12705: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

I2I27_RS12710: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001128.4 |  |  | 0.61 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4 |  |  | 0.59 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002286.3 |  |  | 0.59 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.4 |  |  | 0.59 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4 |  |  | 0.59 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.4 |  |  | 0.59 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001261.3 |  |  | 0.58 | NRPS | AM-toxin | Alternaria alternata
BGC0002135.2 |  |  | 0.57 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001251.4 |  |  | 0.57 | NRPS | epichloenin A | Epichloe festucae
BGC0000357.5 |  |  | 0.57 | NRPS | cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val) | Penicillium rubens Wisconsin 54-1255

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001128.4 |  | 0.64 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4 |  | 0.63 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002286.3 |  | 0.63 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001641.4 |  | 0.63 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4 |  | 0.63 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.4 |  | 0.63 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001261.3 |  | 0.63 | NRPS | AM-toxin | Alternaria alternata
BGC0002135.2 |  | 0.62 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001251.4 |  | 0.62 | NRPS | epichloenin A | Epichloe festucae
BGC0000357.5 |  | 0.62 | NRPS | cyclo-(D-Phe-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Trp-D-Val-L-Val), cyclo-(D-Phe-L-Phe-D-Val-L-Ile), cyclo-(D-Phe-L-Phe-D-Ile-L-Val), cyclo-(D-Tyr-L-Trp-D-Val-L-Ile), cyclo-(D-Tyr-L-Trp-D-Ile-L-Val), cyclo-(D-Tyr-L-Phe-D-Val-L-Ile), cyclo-(D-Tyr-L-Phe-D-Ile-L-Val) | Penicillium rubens Wisconsin 54-1255

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.72 out of 27.78
Confidence: medium
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 30585:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Cys) + (Me-Cys)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
I2I27_RS12700: Cys
Search NORINE for peptide: strict or relaxed
AMP-binding (531..926): Cys
nrpys: Cys

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Small clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Single AA prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TNIAFDLSVYDGNSLLSGDVSLGGATEASIWSIY
  Nearest Stachelhaus code(s):
    Cys DLYNLSLIWK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

I2I27_RS12705: Cys
Search NORINE for peptide: strict or relaxed
AMP-binding (547..945): Cys
nrpys: Cys

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Small clusters prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)
  Single AA prediction:
    Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TEVSFDLSVYDGNSILSGDLAMGGATEAAIWSNF
  Nearest Stachelhaus code(s):
    Cys DLYNMSMIWK (85% 8Å match)
  Stachelhaus code match:
    90% (moderate)

I2I27_RS12710: X
AMP-binding (22..421): X
nrpys: diOH-Bz, Sal

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Small clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    HCYLFALYSPGNGIIIGGAHIGYGATEGIIMYNA
  Nearest Stachelhaus code(s):
    Sal ALPGQGVLNK (41% 8Å match)
  Stachelhaus code match:
    60% (weak)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria

NZ_JADMPO010000001.1 - Region 1 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 294,044 - 311,265 nt. (total: 17,222 nt) Show pHMM detection rules used
Region on contig edge.
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: protease
I2I27_RS01375: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase
I2I27_RS01385: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000504.5 |  | 0.59 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000500.5 |  | 0.58 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0001210.5 |  | 0.51 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0002698.2 |  | 0.47 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0001407.5 |  | 0.46 | ribosomal | bicereucin | Bacillus cereus SJ1
BGC0000527.5 |  | 0.46 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0000516.4 |  | 0.46 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000502.5 |  | 0.45 | ribosomal | cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7 | Bacillus cereus
BGC0000539.5 |  | 0.44 | ribosomal | nukacin ISK-1 | Staphylococcus warneri
BGC0002699.2 |  | 0.44 | ribosomal | nostolysamide A, nostolysamide B | Nostoc punctiforme PCC 73102

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000504.5 |  | 0.59 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000500.5 |  | 0.58 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0001210.5 |  | 0.51 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0002698.2 |  | 0.47 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0001407.5 |  | 0.46 | ribosomal | bicereucin | Bacillus cereus SJ1
BGC0000527.5 |  | 0.46 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0000516.4 |  | 0.46 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000502.5 |  | 0.45 | ribosomal | cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7 | Bacillus cereus
BGC0000539.5 |  | 0.44 | ribosomal | nukacin ISK-1 | Staphylococcus warneri
BGC0002699.2 |  | 0.44 | ribosomal | nostolysamide A, nostolysamide B | Nostoc punctiforme PCC 73102

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for I2I27_RS01385

I2I27_RS01380
Leader:
MKEKNIKEKHLECEVPEKEHYGKKFEDLTPEEMERIQGG
Core:
G D V I P E E L T K S L G M I L S I N G Y K C
Core with dehydrations:
G D V I P E E L Dhb K Dha L G M I L Dha I N G Y K Cys

#### antiSMASH-DB 4.0 matches for I2I27_RS01380

100.0%
NZ_JADMPO010000001.1:
Lanthipeptides: I2I27_RS01380_lanthipeptide
1
G D V I P E E L T K S L G M I L S I N G Y K C
23
G D V I P E E L T K S L G M I L S I N G Y K C
1
G D V I P E E L T K S L G M I L S I N G Y K C
23
38.7%
NZ_JQBU01000033.1 and 1 other:
NZ_JQBV01000009.1 Lanthipeptides: IV76_RS12120_lanthipeptide
Lanthipeptides: IV75_RS14620_lanthipeptide
1
G D V I P E E---------L T K S L G M I L S I N G Y K C
23
G D V+P E L S+G++ +I G K C
1
G D V M P E S T P I C A G F A T L M S S I G L V K T I K G-K C
31
33.3%
NZ_FUXI01000002.1:
Lanthipeptides: B5D30_RS01240_lanthipeptide
1
G D V I P E E L T K S L G M I L S I N G Y K C
23
G D V P+ + + S Y K C
1
G D V N P Q T V G S L W E F L T S K G E Y K C
23
with 6 more sequence matches
26.9%
NZ_JACSMH010000008.1 and 2 others:
NZ_JACSMX010000006.1 Lanthipeptides: KNQ03_RS15615_lanthipeptide NZ_JACSMZ010000005.1 Lanthipeptides: KNQ06_RS16025_lanthipeptide
Lanthipeptides: KNP89_RS14470_lanthipeptide
1
G D V I P E E L T K S L G M I L S I N
19
G D V P E +G+I+ +
1
G D V Q P E T T P F C V G V I V G V T
19
25.0%
NC_018499.1 and 40 others:
NC_018499.1 Lanthipeptides: BCK_RS27855_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27850_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27860_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27855_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27850_lanthipeptide NZ_CP015591.1 Lanthipeptides: A7A70_RS27565_lanthipeptide NZ_CP015591.1 Lanthipeptides: A7A70_RS27560_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27215_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27210_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27215_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27210_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29375_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29370_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29365_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29955_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29950_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29945_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29955_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29950_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29945_lanthipeptide NZ_JACYOF010000027.1 Lanthipeptides: IGI01_RS29005_lanthipeptide NZ_JANIOB010000033.1 Lanthipeptides: NQ113_RS28005_lanthipeptide NZ_JAOPQW010000026.1 Lanthipeptides: OCD10_RS25275_lanthipeptide NZ_JAOPQW010000026.1 Lanthipeptides: OCD10_RS25270_lanthipeptide NZ_JH791925.1 Lanthipeptides: IE3_RS28545_lanthipeptide NZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27570_lanthipeptide NZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27565_lanthipeptide NZ_MLKL01000042.1 Lanthipeptides: BKK45_RS27560_lanthipeptide NZ_NUBO01000052.1 Lanthipeptides: CN575_RS29780_lanthipeptide NZ_NUML01000015.1 Lanthipeptides: COD66_RS20150_lanthipeptide NZ_NUML01000015.1 Lanthipeptides: COD66_RS20145_lanthipeptide NZ_NUVR01000040.1 Lanthipeptides: COI88_RS26655_lanthipeptide NZ_NUVR01000040.1 Lanthipeptides: COI88_RS26650_lanthipeptide NZ_NVJC01000007.1 Lanthipeptides: COM38_RS07400_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23035_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23030_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23025_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23035_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23030_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23025_lanthipeptide
Lanthipeptides: BCK_RS27860_lanthipeptide
1
G D V I P E E L T K S L G
13
G D V P E L+ L G
3
G D V T P E G L S S W L G
15
25.0%
NZ_CP033919.1:
Lanthipeptides: EG347_RS22885_lanthipeptide
3
V I P E E L T K S L G M I L S I N G Y K C
23
V I ++ K S L I + Y C
11
V I D Q D T P K S L S C I A T S C N Y P C
31
19.4%
NZ_CP102973.1 and 1 other:
NZ_FQQG01000014.1 Lanthipeptides: BT790_RS14420_lanthipeptide
Lanthipeptides: NW963_RS14100_lanthipeptide
1
G D V I P E E L T
9
G D V P E T
1
G D V T P E S T T
9
18.8%
NZ_CP036019.1 and 9 others:
NZ_CP036019.1 Lanthipeptides: EXW52_RS27205_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27190_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27180_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27175_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27170_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27190_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27180_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27175_lanthipeptide NZ_CP036019.1 Lanthipeptides: EXW52_RS27170_lanthipeptide
Lanthipeptides: EXW52_RS27205_lanthipeptide
1
G D V I P E E L T K S L G M I L S I N
19
G D V P E + ++++I+
1
G D V S P E T T P A T P T I V V A I S
19
18.2%
NZ_RSCJ01000051.1:
Lanthipeptides: PCC6912_RS34970_lanthipeptide
3
V I P E E L T K S L G M I L S
17
V+P E+L K++ ++S
9
V V P E D L V K A I A Q V M S
23
I2I27_RS01390
Leader:
MMKDNKKELNVITGVAFDDMSIDEMAEVQGA
Core:
G D V E G E V T T P I C A V A V T A S L S I Q V A K T L K G K C
Core with dehydrations:
G D V E G E V Dhb Dhb P I Cys A V A V Dhb A Dha L Dha I Q V A K Dhb L K G K Cys

#### antiSMASH-DB 4.0 matches for I2I27_RS01390

100.0%
NZ_JADMPO010000001.1:
Lanthipeptides: I2I27_RS01390_lanthipeptide
1
G D V E G E V T T P I C A V A V T A S L S I Q V A K T L K G K C
32
G D V E G E V T T P I C A V A V T A S L S I Q V A K T L K G K C
1
G D V E G E V T T P I C A V A V T A S L S I Q V A K T L K G K C
32
56.2%
NZ_FUXI01000002.1:
Lanthipeptides: B5D30_RS01205_lanthipeptide
1
G D V E G E V T T P I C A V A V T A S L S I Q V A K T L K G K C
32
G D V E T T +C A V T A +I Q V +T+K K C
1
G D V N T E-T T T V C A V F A T A C G A I Q V V R T I K K K C
31
56.2%
NZ_JQBU01000033.1 and 1 other:
NZ_JQBV01000009.1 Lanthipeptides: IV76_RS12120_lanthipeptide
Lanthipeptides: IV75_RS14620_lanthipeptide
1
G D V E G E V T T P I C A V A V T A S L S I Q V A K T L K G K C
32
G D V E +T P I C A T S I + K T+K G K C
1
G D V M P E-S T P I C A G F A T L M S S I G L V K T I K G K C
31
with 45 more sequence matches
Only the first 10 are displayed here.
53.1%
NZ_CP102973.1 and 1 other:
NZ_FQQG01000014.1 Lanthipeptides: BT790_RS14420_lanthipeptide
Lanthipeptides: NW963_RS14100_lanthipeptide
1
G D V E G E V T T P I C A V A V T A S L S I Q V A K T L K G K C
32
G D V E T T +C A + + S I Q+ K T L K K C
1
G D V T P E S T T-V C A A F A S F A G S I Q L V K T L K S K C
31
50.0%
NZ_CP086395.1 and 1 other:
NZ_JAKTAW010000012.1 Lanthipeptides: MKK30_RS11185_lanthipeptide
Lanthipeptides: LMK00_RS10670_lanthipeptide
1
G D V E G E V T T P I C A V A V T A S L S I Q V A K T L K G K C
32
G D V E +T P I C ++S I + K T L K G+C
1
G D V E V R-S T P I C T F T A G V T V S I V I V K T L K G R C
31
50.0%
NZ_CP091282.1:
Lanthipeptides: L2Z53_RS12190_lanthipeptide
1
G D V E G E V T T P-------I C A V A V T A S L S I Q V A K T L K G K C
32
G D V E T T P + +V L S I V A K T+K G K C
1
G D V N V E-T T P T A T I S A F L L S V G G G Y E L S I H V A K T V K G K C
38
50.0%
NZ_JADNGS010000002.1:
Lanthipeptides: I2D92_RS06840_lanthipeptide
1
G D V E G E V T T P I C A V----A V T A S L S I Q V A K T L K G K C
32
G D+E T A V A T S S I V K T+K G K C
1
G D I E P N S L T V A S A V L M S A A A T G S F S I A V T K T V K G K C
36
50.0%
NZ_SDJV01000024.1:
Lanthipeptides: ES032_RS12700_lanthipeptide
1
G D V E G E V T T P I C A V A V T A S L S I Q V A K T L K G K C
32
G D V+ E T T P C A + +S V K T+K G C
1
G D V Q V E-T T P A C A F T A S I L V S Y G V V K T I K G H C
31
47.5%
NZ_JAQCQD010000003.1:
Lanthipeptides: PGZ38_RS05480_lanthipeptide
1
G D V E G E V T T P I C A V---------A V T A S L S I Q V A K T L K G K C
32
G D+ E T T P C A+ A V+ S+ V K T L K G K C
1
G D I S P E-T T P A C A L I I S K I I S G A A V S F G F S V S V V K T L K G K C
40
45.0%
NZ_QSIO01000003.1:
Lanthipeptides: DW820_RS07295_lanthipeptide
1
G D V E G E V T T P I C A V---------A V T A S L S I Q V A K T L K G K C
32
G D+ E T T P C + A V+ S+ V K T L K G K C
1
G D I S P E-T T P A C V L I I S N V I S G A A V S F K F S V D V V K T L K G K C
40
43.8%
NZ_JAQDYA010000001.1:
Lanthipeptides: PGT72_RS00020_lanthipeptide
1
G D V E G E V T T P I C A V A V T A S L S I Q V A K T L K G K C
32
G D+ E +T P+C A T + I + K T+K G C
1
G D I T P E-S T P V C A A F A T L A S G I A L V K T I K G N C
31
42.5%
NZ_JAFHCX010000012.1 and 1 other:
NZ_LR738722.1 Lanthipeptides: STREPSUIS_RS04075_lanthipeptide
Lanthipeptides: JXW96_RS06965_lanthipeptide
1
G D V E G E V T T P I C A V---------A V T A S L S I Q V A K T L K G K C
32
G D+ E T T P C A+ A V+ + S+ V K T+K G C
1
G D I S P E-T T P A C A L I I S K A I S G A A V S F A F S V G V V K T V K G N C
40
40.6%
NZ_JAFLVY010000007.1:
Lanthipeptides: JZO73_RS03920_lanthipeptide
1
G D V E G E V T T P I C A V A V T A S L S I Q V A K T L K G K C
32
G D V E + + T + S I + K T L K G C
1
G D V N P E---S V A S F F A T L A S S I A L V K T L K G H C
29
allorf_303591_303701
Leader:
MLGLALIHETSYGG
Core:
I R Y E K R Q T L K N Y N P Y T C F Y K I I
Core with dehydrations:
I R Y E K R Q Dhb L K N Y N P Y Dhb Cys F Y K I I

#### antiSMASH-DB 4.0 matches for allorf_303591_303701

100.0%
NZ_JADMPO010000001.1:
Lanthipeptides: allorf_303591_303701_lanthipeptide
1
I R Y E K R Q T L K N Y N P Y T C F Y K I I
22
I R Y E K R Q T L K N Y N P Y T C F Y K I I
1
I R Y E K R Q T L K N Y N P Y T C F Y K I I
22
22.7%
NZ_JAEQNB010000006.1:
Lanthipeptides: JJB07_RS18745_lanthipeptide
11
N Y N P Y T C F Y K I I
22
+++ Y T C F +I
1
S W S E Y T C F C S L I
12
allorf_303731_303931
Leader:
MRNRIITGFRNMAAS
Core:
I Y N S D I S I P I S N L F C S P P P G C Y L P C S K I T L F K N I Y C K M K Y N H N K M K K I F D I
Core with dehydrations:
I Y N Dha D I Dha I P I Dha N L F Cys Dha P P P G Cys Y L P Cys Dha K I Dhb L F K N I Y Cys K M K Y N H N K M K K I F D I

#### antiSMASH-DB 4.0 matches for allorf_303731_303931

100.0%
NZ_JADMPO010000001.1:
Lanthipeptides: allorf_303731_303931_lanthipeptide
1
I Y N S D I S I P I S N L F C S P P P G C Y L P C S K I T L F K N I Y C K M K Y N H N K M K K I F D I
51
I Y N S D I S I P I S N L F C S P P P G C Y L P C S K I T L F K N I Y C K M K Y N H N K M K K I F D I
1
I Y N S D I S I P I S N L F C S P P P G C Y L P C S K I T L F K N I Y C K M K Y N H N K M K K I F D I
51
13.7%
NZ_CP084530.1 and 1 other:
NZ_CP084530.1 Lanthipeptides: allorf_0461347_0461490_lanthipeptide
Lanthipeptides: allorf_0461347_0461490_lanthipeptide
8
I P I S N L F C S P P
18
I P I S C+P P
1
I P I S E S I C T P P
11
13.2%
NZ_CP011130.1 and 2 others:
NZ_CP023465.1 Lanthipeptides: allorf_4124021_4124236_lanthipeptide NZ_KQ061217.1 Lanthipeptides: allorf_2970820_2971035_lanthipeptide
Lanthipeptides: allorf_4082202_4082426_lanthipeptide
4
S D I S I P I S N L F C S P P P G C
21
S I +S P P G C
17
S R I R A G V S T T A A K P A P G C
34
with 3 more sequence matches
11.8%
NZ_FMCR01000002.1:
Lanthipeptides: allorf_0951186_0951290_lanthipeptide
15
C S P P P G C Y L P C S K I T L F K N I Y
35
C S P P + T F+ +
3
C S P V P A A M A R L G R R T A F R R A W
23
11.8%
NZ_KB905395.1 and 1 other:
NZ_KB905395.1 Lanthipeptides: allorf_13012_13248_lanthipeptide
Lanthipeptides: allorf_13012_13248_lanthipeptide
5
D I S I P I S N L F C S P P P G C Y L P C
25
+ ++P++ L C+ G C C
15
E S A V P L A K L G C N T S D G C G H T C
35
11.8%
NZ_SLXA01000002.1:
Lanthipeptides: allorf_029229_029357_lanthipeptide
14
F C S P P P G C Y L
23
+C S P G C+L
4
Y C S W P T G C F L
13

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.38 out of 27.78
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.55 out of 19.26
Confidence: medium
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.81 out of 28.14
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.99 out of 30.25
Confidence: medium
Additional weak hits (6):
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.30 out of 39.62
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 18.58 out of 30.11
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 18.84 out of 30.11
Confidence: weak
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.08 out of 20.47
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 22.66 out of 26.12
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.94 out of 36.54
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

I2I27_RS01380 - Class II
  Cleavage pHMM score: 2.10
  RODEO score: 0
  Monoisotopic mass: 2425.3 Da
  Molecular weight: 2426.8 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2444.9 Da N = 1
    2462.9 Da N = 2
I2I27_RS01390 - Class II
  Cleavage pHMM score: 3.10
  RODEO score: 0
  Monoisotopic mass: 3079.7 Da
  Molecular weight: 3081.6 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3099.6 Da N = 1
    3117.6 Da N = 2
    3135.6 Da N = 3
    3153.7 Da N = 4
allorf_303591_303701 - Class II
  Cleavage pHMM score: -1.10
  RODEO score: 0
  Monoisotopic mass: 2817.5 Da
  Molecular weight: 2819.3 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2837.3 Da N = 1
allorf_303731_303931 - Class II
  Cleavage pHMM score: -6.40
  RODEO score: 0
  Monoisotopic mass: 5834.0 Da
  Molecular weight: 5838.0 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    5856.0 Da N = 1
    5874.0 Da N = 2

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator
PerR | Peroxide regulator

NZ_JADMPO010000023.1 - Region 1 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 20,339 nt. (total: 20,339 nt) Show pHMM detection rules used
Region on contig edge.
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: glycosyltransferase
I2I27_RS14460: glycosyl transferase group 1

smcogs
  SMCOG1045: glycosyl transferase group 1

Hydrolases: back translocase
I2I27_RS14395: GTP-binding protein LepA

smcogs
  SMCOG1190: GTP-binding protein LepA

Ligases: synthase synthetase
I2I27_RS14420: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

I2I27_RS14425: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.38 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0001456.3 |  | 0.38 | terpene | isorenieratene | Streptomyces argillaceus
BGC0001605.3 |  | 0.38 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0000665.5 |  | 0.37 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0000633.3 |  | 0.37 | terpene | carotenoid | Streptomyces avermitilis
BGC0001227.3 |  | 0.36 | terpene | isorenieratene | Streptomyces collinus Tu 365

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.38 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0001456.3 |  | 0.38 | terpene | isorenieratene | Streptomyces argillaceus
BGC0001605.3 |  | 0.38 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0000665.5 |  | 0.37 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0000633.3 |  | 0.37 | terpene | carotenoid | Streptomyces avermitilis
BGC0001227.3 |  | 0.36 | terpene | isorenieratene | Streptomyces collinus Tu 365

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
I2I27_RS14420: PT_FPPS_like
Domain 1 (32 - 295): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  IPP, DMAPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.54 out of 18.46
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.61 out of 20.97
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 18.96 out of 23.79
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.87 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.85 out of 28.19
Confidence: medium
Additional weak hits (4):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.57 out of 26.06
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.91 out of 31.73
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 21.71 out of 33.73
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.40 out of 33.14
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
IolR | Regulator of the inositol catabolism
RpoN | Regulator of nitrogen assimilation and virulence
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_JADMPO010000003.1 - Region 1 - darobactin,ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 226,474 - 248,068 nt. (total: 21,595 nt) Show pHMM detection rules used
Region on contig edge.
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))
darobactin: ((cds(PF04055 and (TIGR04085 or SPASM)) and darobactin_precursor) or darobactin_rSAM)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ranthipeptide | darobactin | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0002306.2 |  |  | 0.32 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002306.2 |  | 0.47 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.50 out of 27.78
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.40 out of 27.55
Confidence: medium
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.94 out of 21.55
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.05 out of 27.78
Confidence: medium
Additional weak hits (3):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.56 out of 26.06
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.55 out of 30.25
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 23.91 out of 30.98
Confidence: weak
RREFinder
TFBS Finder
RRE predictions
RREfinder results sidepanel.

ranthipeptide protocluster (226473...248068)
I2I27_RS04065
  RRE type: Ranthipeptide_rSAM_RRE
  Location: 0 - 111
  Score: 90.4
darobactin protocluster (226473...247895)
I2I27_RS04065
  RRE type: Ranthipeptide_rSAM_RRE
  Location: 0 - 111
  Score: 90.4

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArcA | Repressor of carbon oxidation
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM | Regulator of nitrogen-fixation genes

NZ_JADMPO010000043.1 - Region 1 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 11,375 nt. (total: 11,375 nt) Show pHMM detection rules used
Region on contig edge.
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: cyclase
I2I27_RS16800: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000525.5 |  | 0.44 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000554.4 |  | 0.42 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0002704.2 |  | 0.41 | ribosomal | archalan β | Halorussus salinus
BGC0001210.5 |  | 0.36 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0002699.2 |  | 0.35 | ribosomal | nostolysamide A, nostolysamide B | Nostoc punctiforme PCC 73102
BGC0000539.5 |  | 0.35 | ribosomal | nukacin ISK-1 | Staphylococcus warneri
BGC0000516.4 |  | 0.35 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000527.5 |  | 0.34 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0000517.4 |  | 0.33 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0001407.5 |  | 0.32 | ribosomal | bicereucin | Bacillus cereus SJ1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000525.5 |  | 0.44 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000554.4 |  | 0.42 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0002704.2 |  | 0.41 | ribosomal | archalan β | Halorussus salinus
BGC0001210.5 |  | 0.36 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0002699.2 |  | 0.35 | ribosomal | nostolysamide A, nostolysamide B | Nostoc punctiforme PCC 73102
BGC0000539.5 |  | 0.35 | ribosomal | nukacin ISK-1 | Staphylococcus warneri
BGC0000516.4 |  | 0.35 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000527.5 |  | 0.34 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0000517.4 |  | 0.33 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0001407.5 |  | 0.32 | ribosomal | bicereucin | Bacillus cereus SJ1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for I2I27_RS16800

I2I27_RS16805
Leader:
MADSRVLEMYAGNLLEEMQEIEKM
Core:
I P G D Q E N E I V S S H T V G C S A F L T I Y C C
Core with dehydrations:
I P G D Q E N E I V Dha Dha H Dhb V G Cys Dha A F L Dhb I Y Cys Cys

#### antiSMASH-DB 4.0 matches for I2I27_RS16805

100.0%
NZ_CP070036.1 and 2 others:
NZ_JADMPO010000043.1 Lanthipeptides: I2I27_RS16805_lanthipeptide NZ_JAQMLK010000037.1 Lanthipeptides: PNW18_RS16660_lanthipeptide
Lanthipeptides: I6K72_RS03970_lanthipeptide
1
I P G D Q E N E I V S S H T V G C S A F L T I Y C C
26
I P G D Q E N E I V S S H T V G C S A F L T I Y C C
1
I P G D Q E N E I V S S H T V G C S A F L T I Y C C
26
96.2%
NZ_JADNGF010000061.1:
Lanthipeptides: I2E06_RS15650_lanthipeptide
1
I P G D Q E N E I V S S H T V G C S A F L T I Y C C
26
I P D Q E N E I V S S H T V G C S A F L T I Y C C
1
I P E D Q E N E I V S S H T V G C S A F L T I Y C C
26
60.5%
NZ_CYZG01000001.1:
Lanthipeptides: ARA00_RS15445_lanthipeptide
1
I P G D Q E N E I V S S H T V G C S A F L T I Y C C
26
I P D Q E N E+V S S H T V G C A F L T I Y C C
13
I P E D Q E N E L V S S H T V G C G A F L T I Y C C
38
with 26 more sequence matches
Only the first 10 are displayed here.
42.3%
NZ_WWSD01000018.1:
Lanthipeptides: GT593_RS11715_lanthipeptide
12
S H T V G C S A F L T I Y C C
26
+H T+G C+A L T I Y C C
1
T H T I G C A A L L T I Y C C
15
38.5%
NZ_CP036170.1:
Lanthipeptides: HDCHBGLK_RS18795_lanthipeptide
12
S H T V G C S A F L T I Y C C
26
S T+ C F L T I Y C C
5
S T T I K C G T F L T I Y C C
19
34.6%
NZ_SPFR01000005.1:
Lanthipeptides: FGQ83_RS17540_lanthipeptide
12
S H T V G C S A F L T I Y C C
26
+ T G C S F T I C C
1
T W T K G C S Q F C T I I C C
15
30.8%
NZ_CP015849.1:
Lanthipeptides: A8713_RS33905_lanthipeptide
11
S S H T V G C S A F L T I Y C C
26
++ T V G C S T I C
1
A A S T V G C S G L C T I I V C
16
28.2%
NZ_QGDL01000005.1:
Lanthipeptides: A8806_RS26140_lanthipeptide
8
E I V S S H T V G C S A F L T I Y C C
26
E + ++T V G C S T I Y C C
21
E Q I F T N T V G C S N L F T I Y C C
39
28.2%
NZ_SLXA01000002.1:
Lanthipeptides: EV212_RS13395_lanthipeptide
8
E I V S S H T V G C S A F L T I Y C C
26
E S +V C S L T I Y C C
21
E Q K D S F S V E C S P I L T I Y C C
39
26.9%
NZ_CP036071.1:
Lanthipeptides: allorf_19132_19248_lanthipeptide
11
S S H T V G C S A F L T
22
S + V G C S+F L+
2
S F Y F V G C S S F L S
13
26.9%
NZ_CP048607.1:
Lanthipeptides: allorf_4196740_4196883_lanthipeptide
9
I V S S H T V G C S A F L
21
I V T+G C+A L
7
I V E C G T I G C T A I L
19
26.9%
NZ_CP102267.1 and 2 others:
NZ_JADMOE010000006.1 Lanthipeptides: I2G55_RS05425_lanthipeptide NZ_LT635469.1 Lanthipeptides: BQ7352_RS14540_lanthipeptide
Lanthipeptides: NQ550_RS10225_lanthipeptide
18
S A F L T I Y C C
26
S+F L T I C C
4
S S F L T I V C C
12
26.9%
NZ_CP113781.1:
Lanthipeptides: GGADHKLB_RS14125_lanthipeptide
15
V G C S A F L T I Y C C
26
+ C+ F L T I C C
1
L N C T H F L T I L C C
12
I2I27_RS16845
Leader:
MDQFVKQVLEEEKFSQEQKSYLLDCLEQGEEMEEVLYL
Core:
A K S C L S V E Q M E R I K Q L L S E H S Q M F R C S W R K S W N K K K R D K E G
Core with dehydrations:
A K Dha Cys L Dha V E Q M E R I K Q L L Dha E H Dha Q M F R Cys Dha W R K Dha W N K K K R D K E G

#### antiSMASH-DB 4.0 matches for I2I27_RS16845

100.0%
NZ_CP070036.1 and 2 others:
NZ_JADMPO010000043.1 Lanthipeptides: I2I27_RS16845_lanthipeptide NZ_JAQMLK010000037.1 Lanthipeptides: PNW18_RS16700_lanthipeptide
Lanthipeptides: I6K72_RS03930_lanthipeptide
1
A K S C L S V E Q M E R I K Q L L S E H S Q M F R C S W R K S W N K K K R D K E G
41
A K S C L S V E Q M E R I K Q L L S E H S Q M F R C S W R K S W N K K K R D K E G
1
A K S C L S V E Q M E R I K Q L L S E H S Q M F R C S W R K S W N K K K R D K E G
41
24.4%
NZ_CP039297.1 and 3 others:
NZ_CP040672.1 Lanthipeptides: allorf_1096518_1096664_lanthipeptide NZ_CP059318.1 Lanthipeptides: allorf_0101519_0101665_lanthipeptide NZ_CP087137.1 Lanthipeptides: allorf_0101357_0101503_lanthipeptide
Lanthipeptides: allorf_0101584_0101730_lanthipeptide
10
M E R I K Q L L S-E H S Q M F R C S W R K S W
32
M R Q L S H R C W+ +W
2
M L R C F Q H L S R P H I A T Q R C P W Q N N W
25

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
No hits above weak threshold.
Weak hits (3):
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.59 out of 31.73
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.12 out of 33.14
Confidence: weak
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.96 out of 27.04
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

I2I27_RS16805 - Class II
  Cleavage pHMM score: -5.20
  RODEO score: 0
  Monoisotopic mass: 2695.2 Da
  Molecular weight: 2697.0 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2715.0 Da N = 1
    2733.0 Da N = 2
I2I27_RS16845 - Class II
  Cleavage pHMM score: -4.10
  RODEO score: 0
  Monoisotopic mass: 4886.5 Da
  Molecular weight: 4889.6 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4907.7 Da N = 1
    4925.7 Da N = 2
    4943.7 Da N = 3
    4961.7 Da N = 4

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---

NZ_JADMPO010000008.1 - Region 1 - RRE-containing
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 39,495 - 60,454 nt. (total: 20,960 nt) Show pHMM detection rules used
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RRE-containing | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002306.2 |  | 0.61 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000599.5 |  | 0.38 | ribosomal | thuricin CD α, thuricin CD β | Bacillus thuringiensis
BGC0001210.5 |  | 0.37 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000626.3 |  | 0.37 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000521.3 |  | 0.36 | ribosomal | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0000539.5 |  | 0.36 | ribosomal | nukacin ISK-1 | Staphylococcus warneri
BGC0002323.2 |  | 0.34 | ribosomal | nisin J | Staphylococcus capitis
BGC0001618.3 |  | 0.34 | ribosomal | hyicin 3682 | Staphylococcus hyicus
BGC0000542.3 |  | 0.34 | ribosomal | paenicidin B | Paenibacillus terrae
BGC0001779.5 |  | 0.34 | ribosomal | siamycin | Streptomyces nodosus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002306.2 |  | 0.61 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000599.5 |  | 0.38 | ribosomal | thuricin CD α, thuricin CD β | Bacillus thuringiensis
BGC0001210.5 |  | 0.37 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000626.3 |  | 0.37 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000521.3 |  | 0.36 | ribosomal | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0000539.5 |  | 0.36 | ribosomal | nukacin ISK-1 | Staphylococcus warneri
BGC0002323.2 |  | 0.34 | ribosomal | nisin J | Staphylococcus capitis
BGC0001618.3 |  | 0.34 | ribosomal | hyicin 3682 | Staphylococcus hyicus
BGC0000542.3 |  | 0.34 | ribosomal | paenicidin B | Paenibacillus terrae
BGC0001779.5 |  | 0.34 | ribosomal | siamycin | Streptomyces nodosus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.58 out of 21.84
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 22.97 out of 24.78
Confidence: strong
Additional weak hits (1):
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.75 out of 39.62
Confidence: weak
RREFinder
TFBS Finder
RRE predictions
RREfinder results sidepanel.

RRE-containing protocluster (39494...60454)
I2I27_RS08390
  RRE type: Other_Sactipeptide_rSAM_RRE
  Location: 4 - 118
  Score: 44.6

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
LexA variant 2 | Repressor of DNA damage response
MexT | Global virulence regulator