GCF_014837105.1 - 9 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_JACSPO010000013.1 (Oceanitalea stevensii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 4.1	lanthipeptide-class-ii	18,061	44,264

NZ_JACSPO010000014.1 (Oceanitalea stevensii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 5.1	terpene-precursor	6,385	27,491	Low	CDA1b/CDA2a/CDA2b/CDA3a/CDA3b/CDA4a/CDA4b	NRPS:Type I

NZ_JACSPO010000001.1 (Oceanitalea stevensii)

Region	Type	From	To
Region 11.1	azole-containing-RiPP	345,433	368,784
Region 11.2	terpene-precursor	500,141	521,220
Region 11.3	lanthipeptide-class-v	696,669	738,674
Region 11.4	lassopeptide	977,407	1,002,117

NZ_JACSPO010000002.1 (Oceanitalea stevensii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 20.1	T3PKS	272,713	300,332	High	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone/2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	PKS:Type III

NZ_JACSPO010000004.1 (Oceanitalea stevensii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 22.1	terpene	18,535	42,695	Medium	carotenoid	terpene

NZ_JACSPO010000008.1 (Oceanitalea stevensii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 26.1	ectoine	38,434	48,823	Medium	ectoine	other:ectoine

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 4.1	lanthipeptide-class-ii	18,061	44,264
Region 5.1	terpene-precursor	6,385	27,491	Low	CDA1b/CDA2a/CDA2b/CDA3a/CDA3b/CDA4a/CDA4b	NRPS:Type I
Region 11.1	azole-containing-RiPP	345,433	368,784
Region 11.2	terpene-precursor	500,141	521,220
Region 11.3	lanthipeptide-class-v	696,669	738,674
Region 11.4	lassopeptide	977,407	1,002,117
Region 20.1	T3PKS	272,713	300,332	High	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone/2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	PKS:Type III
Region 22.1	terpene	18,535	42,695	Medium	carotenoid	terpene
Region 26.1	ectoine	38,434	48,823	Medium	ectoine	other:ectoine

No secondary metabolite regions were found in these records:: NZ_JACSPO010000010.1 (Oceanitalea stevensii); NZ_JACSPO010000011.1 (Oceanitalea stevensii); NZ_JACSPO010000012.1 (Oceanitalea stevensii); NZ_JACSPO010000015.1 (Oceanitalea stevensii); NZ_JACSPO010000016.1 (Oceanitalea stevensii); NZ_JACSPO010000017.1 (Oceanitalea stevensii); NZ_JACSPO010000018.1 (Oceanitalea stevensii); NZ_JACSPO010000019.1 (Oceanitalea stevensii); NZ_JACSPO010000020.1 (Oceanitalea stevensii); NZ_JACSPO010000021.1 (Oceanitalea stevensii); NZ_JACSPO010000022.1 (Oceanitalea stevensii); NZ_JACSPO010000023.1 (Oceanitalea stevensii); NZ_JACSPO010000024.1 (Oceanitalea stevensii); NZ_JACSPO010000025.1 (Oceanitalea stevensii); NZ_JACSPO010000026.1 (Oceanitalea stevensii); NZ_JACSPO010000027.1 (Oceanitalea stevensii); NZ_JACSPO010000003.1 (Oceanitalea stevensii); NZ_JACSPO010000005.1 (Oceanitalea stevensii); NZ_JACSPO010000006.1 (Oceanitalea stevensii); NZ_JACSPO010000007.1 (Oceanitalea stevensii); NZ_JACSPO010000009.1 (Oceanitalea stevensii)

Compact view

NZ_JACSPO010000013.1 - Region 1 - lanthipeptide-class-ii

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Location: 18,061 - 44,264 nt. (total: 26,204 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

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Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

H9624_RS14880: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

H9624_RS14890: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Isomerases: mutase

H9624_RS14930: phosphoglycerate mutase

smcogs: SMCOG1101: phosphoglycerate mutase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001229.4	0.61	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0002110.3	0.60	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000520.5	0.55	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0000503.5	0.54	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0000623.3	0.53	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000554.4	0.51	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000517.4	0.51	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0002005.2	0.51	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0001391.3	0.51	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0002346.3	0.50	ribosomal	kyamicin	Saccharopolyspora sp.

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001229.4	0.61	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0002110.3	0.60	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000520.5	0.55	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0000503.5	0.54	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0000623.3	0.53	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000554.4	0.51	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000517.4	0.51	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0002005.2	0.51	ribosomal	RaxX	Xanthomonas oryzae pv. oryzae
BGC0001391.3	0.51	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0002346.3	0.50	ribosomal	kyamicin	Saccharopolyspora sp.

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for H9624_RS14880

H9624_RS14865

Leader:

MRLRRIAAA

Core:

SLVLSATVVLGPPALAADTGTAVRAASPPVAEPATFLGDLACQVLGDFFEKC

Core with dehydrations:

DhaLVLDhaADhbVVLGPPALAADDhbGDhbAVRAADhaPPVAEPADhbFLGDLACysQVLGDFFEKCys

antiSMASH-DB 4.0 matches for H9624_RS14865

100.0%

NZ_JACSPO010000013.1and 1 other:

NZ_JACSPO010000013.1 Lanthipeptides: H9624_RS14865_lanthipeptide

Lanthipeptides: H9624_RS14865_lanthipeptide

1

SLVLSATVVLGPPALAADTGTAVRAASPPVAEPATFLGDLACQVLGDFFEKC

52

SLVLSATVVLGPPALAADTGTAVRAASPPVAEPATFLGDLACQVLGDFFEKC

1

SLVLSATVVLGPPALAADTGTAVRAASPPVAEPATFLGDLACQVLGDFFEKC

52

19.2%

NZ_CP070496.1:

Lanthipeptides: allorf_3787427_3787648_lanthipeptide

27

SPPVAEP---ATFLGDLACQVLGDFFEKC

52

PP + P F G++AC V F C

19

QPPGSSPRARGAFTGEVACDVAVGFIPAC

47

17.3%

NZ_NNBN01000001.1and 1 other:

NZ_NNBN01000001.1 Lanthipeptides: allorf_771486_771668_lanthipeptide

Lanthipeptides: allorf_771486_771668_lanthipeptide

15

LAADTGTAVRAASPPVAEPA

34

+AA TG AV A + + PA

20

IAASTGRAVSARTTEIRNPA

39

with 1 more sequence matches

11.5%

NZ_CP030771.1:

Lanthipeptides: allorf_09785478_09785648_lanthipeptide

44

VLGDFFEKC

52

VL D F KC

16

VLNDHFRKC

24

H9624_RS14885

Leader:

MFTTRDYTRANGYVSDAELVELTEDTVVDAA

Core:

AGTTTVPCAIGGGVIAISAALPDFCPTGACTTRC

Core with dehydrations:

AGDhbDhbDhbVPCysAIGGGVIAIDhaAALPDFCysPDhbGACysDhbDhbRCys

antiSMASH-DB 4.0 matches for H9624_RS14885

100.0%

NZ_JACSPO010000013.1and 1 other:

NZ_JACSPO010000013.1 Lanthipeptides: H9624_RS14885_lanthipeptide

Lanthipeptides: H9624_RS14885_lanthipeptide

1

AGTTTVPCAIGGGVIAISAALPDFCPTGACTTRC

34

AGTTTVPCAIGGGVIAISAALPDFCPTGACTTRC

1

AGTTTVPCAIGGGVIAISAALPDFCPTGACTTRC

34

68.6%

NZ_JALGRP010000007.1and 1 other:

NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12965_lanthipeptide

Lanthipeptides: MT347_RS12965_lanthipeptide

3

TTTVPCAIGGGVIAISAALPDFCPTGACTTRC

34

TTT PCA+ G IA +AALP FCPTGACTTRC

1

TTTAPCAVAGLTIAATAALPGFCPTGACTTRC

32

52.9%

NZ_NTSF01000026.1and 1 other:

NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21840_lanthipeptide

Lanthipeptides: CN325_RS21840_lanthipeptide

3

TTTVPCAIGGGVIAISAALPDFCPTGACTTRC

34

+TTVPC I G I IS A +CPT CT RC

2

STTVPCGI-GSTITISIA---YCPTSKCTERC

29

with 113 more sequence matches

Only the first 10 are displayed here.

46.2%

NZ_VTZW01000015.1and 1 other:

NZ_VTZW01000015.1 Lanthipeptides: FZ103_RS15840_lanthipeptide

Lanthipeptides: FZ103_RS15840_lanthipeptide

3

TTTVPC---AIGGGVIAISAALPDFCPTGACTTRC

34

+TTV C A+ + A SAA+ D CPT ACTT C

5

STTVVCGISAVTSAITAASAAMGDNCPTTACTTYC

39

41.2%

NZ_CP013862.1and 1 other:

NZ_CP013862.1 Lanthipeptides: AOX59_RS09365_lanthipeptide

Lanthipeptides: AOX59_RS09365_lanthipeptide

5

TVPCAIGGGVIAISAALPDFCPTGACTTRC

34

T P ++ G IA+SA FCPT CT++C

7

TTPSSVACG-IAVSAL---FCPTTKCTSQC

32

41.2%

NZ_FQZK01000006.1and 2 others:

NZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13105_lanthipeptideNZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13105_lanthipeptide

Lanthipeptides: BUE45_RS13105_lanthipeptide

12

GGVIAISAALPDFCPTGACTTRC

34

V AISAA D CPT CT+RC

6

ASVTAISAAWGDGCPTTVCTSRC

28

41.2%

NZ_LT630004.1:

Lanthipeptides: BQ5796_RS18310_lanthipeptide

3

TTTVPCAIGGGVIAISAALPDFCPTGACTTRC

34

TTT+PC G + IS ++ CPT CT++C

1

TTTLPCV--GITVTISVSM---CPTTKCTSQC

27

41.2%

NZ_QKTG01000020.1and 1 other:

NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS08060_lanthipeptide

Lanthipeptides: DEI99_RS08060_lanthipeptide

18

SAALPDFCPTGACTTRC

34

SAALP FCPTGACT++C

1

SAALPGFCPTGACTSKC

17

40.5%

NZ_CM000756.1and 17 others:

NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptideNZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14765_lanthipeptideNZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptide

Lanthipeptides: BTHUR0011_RS14765_lanthipeptide

1

AGTTTVPCAIGGGVIAISAALPDFCPTGACTTRC

34

AGT + AI V A++A P CPT AC+ C

5

AGTPAIVTAISA-VTAVTAQSP--CPTSACSKSC

35

40.5%

NZ_NTSR01000029.1and 1 other:

NZ_NTSR01000029.1 Lanthipeptides: CN358_RS25165_lanthipeptide

Lanthipeptides: CN358_RS25165_lanthipeptide

4

TTVPCAIGGGVIAISAALPDF----CPTGACTTRC

34

TTVPCA+GG + I+ D CPT AC++RC

7

TTVPCAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

38.5%

NZ_BLIS01000009.1and 5 others:

NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04825_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptide

Lanthipeptides: GVO03_RS04825_lanthipeptide

9

AIGGGVIAISAALP-DFCPTGACTTRC

34

AIG GVIA++A + + CPT ACT C

13

AIGKGVIAVTAFVSANTCPTSACTRAC

39

38.5%

NZ_CP009280.1and 1 other:

NZ_CP009280.1 Lanthipeptides: P40081_RS37160_lanthipeptide

Lanthipeptides: P40081_RS37160_lanthipeptide

3

TTTVPCAIGGGVIAISAALPDFCPTGACTTRC

34

T++ PC IG + ISA L CPT CT++C

13

TSSWPCVIGA--VDISANL---CPTTKCTSKC

39

38.2%

NZ_CP017762.1and 3 others:

NZ_CP017762.1 Lanthipeptides: BKP57_RS21840_lanthipeptideNZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptideNZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptide

Lanthipeptides: BKP57_RS21840_lanthipeptide

3

TTTVPCAIGGGVIAISAALPDFCPTGACTTRC

34

TTTVPCA+ + CPT AC+++C

1

TTTVPCAVAASI--------ALCPTLACSSKC

24

MIBiG 4.0 matches for H9624_RS14885

40.5%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

9

AIGGGV-IAISAALPDFCPTGACTTRC

34

AI GV + +SAA FCPT CT+RC

14

AIQAGVAVGVSAA---FCPTTKCTSRC

37

20.6%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

24

FCPTGACTTRC

34

FCPT CT++C

16

FCPTTKCTSKC

26

H9624_RS14910

Leader:

MNQQARPGVSEIVTFAAA

Core:

ALCAALGLFVSPRYGGATWVVLAVAALLVWQGLVLRRRRTGPASQT

Core with dehydrations:

ALCysAALGLFVDhaPRYGGADhbWVVLAVAALLVWQGLVLRRRRDhbGPADhaQDhb

antiSMASH-DB 4.0 matches for H9624_RS14910

100.0%

NZ_JACSPO010000013.1and 1 other:

NZ_JACSPO010000013.1 Lanthipeptides: H9624_RS14910_lanthipeptide

Lanthipeptides: H9624_RS14910_lanthipeptide

1

ALCAALGLFVSPRYGGATWVVLAVAALLVWQGLVLRRRRTGPASQT

46

ALCAALGLFVSPRYGGATWVVLAVAALLVWQGLVLRRRRTGPASQT

1

ALCAALGLFVSPRYGGATWVVLAVAALLVWQGLVLRRRRTGPASQT

46

21.7%

NZ_AKXV01000031.1and 1 other:

NZ_AKXV01000031.1 Lanthipeptides: Y19_RS44045_lanthipeptide

Lanthipeptides: Y19_RS44045_lanthipeptide

14

YGGATW---VVLAVAALL

28

YGG TW +V AVA L+

15

YGGTTWSCAIVTAVATLV

32

15.7%

NZ_BMSB01000008.1:

Lanthipeptides: allorf_182878_183105_lanthipeptide

27

LLVWQGLVLRRRRTGPASQT

46

L+ W G R R T P + T

5

LIGWAGQPCRSRSTAPGTNT

24

MIBiG 4.0 matches for H9624_RS14910

8.7%

BGC0000563.4 (AEA03263.1):

Lanthipeptide: venezuelin

1

ALCAALGLF

9

A C +GL

1

ATCECVGLL

9

8.7%

BGC0001889.2 (fusA):

Lasso peptide: fusilassin

8

LFVSPRY

14

+FV PR+

11

IFVFPRF

17

Lanthipeptide(s) for H9624_RS14890

H9624_RS14865

Leader:

MRLRRIAAA

Core:

SLVLSATVVLGPPALAADTGTAVRAASPPVAEPATFLGDLACQVLGDFFEKC

Core with dehydrations:

DhaLVLDhaADhbVVLGPPALAADDhbGDhbAVRAADhaPPVAEPADhbFLGDLACysQVLGDFFEKCys

antiSMASH-DB 4.0 matches for H9624_RS14865

100.0%

NZ_JACSPO010000013.1and 1 other:

NZ_JACSPO010000013.1 Lanthipeptides: H9624_RS14865_lanthipeptide

Lanthipeptides: H9624_RS14865_lanthipeptide

1

SLVLSATVVLGPPALAADTGTAVRAASPPVAEPATFLGDLACQVLGDFFEKC

52

SLVLSATVVLGPPALAADTGTAVRAASPPVAEPATFLGDLACQVLGDFFEKC

1

SLVLSATVVLGPPALAADTGTAVRAASPPVAEPATFLGDLACQVLGDFFEKC

52

19.2%

NZ_CP070496.1:

Lanthipeptides: allorf_3787427_3787648_lanthipeptide

27

SPPVAEP---ATFLGDLACQVLGDFFEKC

52

PP + P F G++AC V F C

19

QPPGSSPRARGAFTGEVACDVAVGFIPAC

47

17.3%

NZ_NNBN01000001.1and 1 other:

NZ_NNBN01000001.1 Lanthipeptides: allorf_771486_771668_lanthipeptide

Lanthipeptides: allorf_771486_771668_lanthipeptide

15

LAADTGTAVRAASPPVAEPA

34

+AA TG AV A + + PA

20

IAASTGRAVSARTTEIRNPA

39

with 1 more sequence matches

11.5%

NZ_CP030771.1:

Lanthipeptides: allorf_09785478_09785648_lanthipeptide

44

VLGDFFEKC

52

VL D F KC

16

VLNDHFRKC

24

H9624_RS14885

Leader:

MFTTRDYTRANGYVSDAELVELTEDTVVDAA

Core:

AGTTTVPCAIGGGVIAISAALPDFCPTGACTTRC

Core with dehydrations:

AGDhbDhbDhbVPCysAIGGGVIAIDhaAALPDFCysPDhbGACysDhbDhbRCys

antiSMASH-DB 4.0 matches for H9624_RS14885

100.0%

NZ_JACSPO010000013.1and 1 other:

NZ_JACSPO010000013.1 Lanthipeptides: H9624_RS14885_lanthipeptide

Lanthipeptides: H9624_RS14885_lanthipeptide

1

AGTTTVPCAIGGGVIAISAALPDFCPTGACTTRC

34

AGTTTVPCAIGGGVIAISAALPDFCPTGACTTRC

1

AGTTTVPCAIGGGVIAISAALPDFCPTGACTTRC

34

68.6%

NZ_JALGRP010000007.1and 1 other:

NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12965_lanthipeptide

Lanthipeptides: MT347_RS12965_lanthipeptide

3

TTTVPCAIGGGVIAISAALPDFCPTGACTTRC

34

TTT PCA+ G IA +AALP FCPTGACTTRC

1

TTTAPCAVAGLTIAATAALPGFCPTGACTTRC

32

52.9%

NZ_NTSF01000026.1and 1 other:

NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21840_lanthipeptide

Lanthipeptides: CN325_RS21840_lanthipeptide

3

TTTVPCAIGGGVIAISAALPDFCPTGACTTRC

34

+TTVPC I G I IS A +CPT CT RC

2

STTVPCGI-GSTITISIA---YCPTSKCTERC

29

with 113 more sequence matches

Only the first 10 are displayed here.

46.2%

NZ_VTZW01000015.1and 1 other:

NZ_VTZW01000015.1 Lanthipeptides: FZ103_RS15840_lanthipeptide

Lanthipeptides: FZ103_RS15840_lanthipeptide

3

TTTVPC---AIGGGVIAISAALPDFCPTGACTTRC

34

+TTV C A+ + A SAA+ D CPT ACTT C

5

STTVVCGISAVTSAITAASAAMGDNCPTTACTTYC

39

41.2%

NZ_CP013862.1and 1 other:

NZ_CP013862.1 Lanthipeptides: AOX59_RS09365_lanthipeptide

Lanthipeptides: AOX59_RS09365_lanthipeptide

5

TVPCAIGGGVIAISAALPDFCPTGACTTRC

34

T P ++ G IA+SA FCPT CT++C

7

TTPSSVACG-IAVSAL---FCPTTKCTSQC

32

41.2%

NZ_FQZK01000006.1and 2 others:

NZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13105_lanthipeptideNZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13105_lanthipeptide

Lanthipeptides: BUE45_RS13105_lanthipeptide

12

GGVIAISAALPDFCPTGACTTRC

34

V AISAA D CPT CT+RC

6

ASVTAISAAWGDGCPTTVCTSRC

28

41.2%

NZ_LT630004.1:

Lanthipeptides: BQ5796_RS18310_lanthipeptide

3

TTTVPCAIGGGVIAISAALPDFCPTGACTTRC

34

TTT+PC G + IS ++ CPT CT++C

1

TTTLPCV--GITVTISVSM---CPTTKCTSQC

27

41.2%

NZ_QKTG01000020.1and 1 other:

NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS08060_lanthipeptide

Lanthipeptides: DEI99_RS08060_lanthipeptide

18

SAALPDFCPTGACTTRC

34

SAALP FCPTGACT++C

1

SAALPGFCPTGACTSKC

17

40.5%

NZ_CM000756.1and 17 others:

NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptideNZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14765_lanthipeptideNZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptideNZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptideNZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptideNZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptide

Lanthipeptides: BTHUR0011_RS14765_lanthipeptide

1

AGTTTVPCAIGGGVIAISAALPDFCPTGACTTRC

34

AGT + AI V A++A P CPT AC+ C

5

AGTPAIVTAISA-VTAVTAQSP--CPTSACSKSC

35

40.5%

NZ_NTSR01000029.1and 1 other:

NZ_NTSR01000029.1 Lanthipeptides: CN358_RS25165_lanthipeptide

Lanthipeptides: CN358_RS25165_lanthipeptide

4

TTVPCAIGGGVIAISAALPDF----CPTGACTTRC

34

TTVPCA+GG + I+ D CPT AC++RC

7

TTVPCAVGGATVGITIYTFDRSHQSCPTSACSSRC

41

38.5%

NZ_BLIS01000009.1and 5 others:

NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04825_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptide

Lanthipeptides: GVO03_RS04825_lanthipeptide

9

AIGGGVIAISAALP-DFCPTGACTTRC

34

AIG GVIA++A + + CPT ACT C

13

AIGKGVIAVTAFVSANTCPTSACTRAC

39

38.5%

NZ_CP009280.1and 1 other:

NZ_CP009280.1 Lanthipeptides: P40081_RS37160_lanthipeptide

Lanthipeptides: P40081_RS37160_lanthipeptide

3

TTTVPCAIGGGVIAISAALPDFCPTGACTTRC

34

T++ PC IG + ISA L CPT CT++C

13

TSSWPCVIGA--VDISANL---CPTTKCTSKC

39

38.2%

NZ_CP017762.1and 3 others:

NZ_CP017762.1 Lanthipeptides: BKP57_RS21840_lanthipeptideNZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptideNZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptide

Lanthipeptides: BKP57_RS21840_lanthipeptide

3

TTTVPCAIGGGVIAISAALPDFCPTGACTTRC

34

TTTVPCA+ + CPT AC+++C

1

TTTVPCAVAASI--------ALCPTLACSSKC

24

MIBiG 4.0 matches for H9624_RS14885

40.5%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

9

AIGGGV-IAISAALPDFCPTGACTTRC

34

AI GV + +SAA FCPT CT+RC

14

AIQAGVAVGVSAA---FCPTTKCTSRC

37

20.6%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

24

FCPTGACTTRC

34

FCPT CT++C

16

FCPTTKCTSKC

26

H9624_RS14910

Leader:

MNQQARPGVSEIVTFAAA

Core:

ALCAALGLFVSPRYGGATWVVLAVAALLVWQGLVLRRRRTGPASQT

Core with dehydrations:

ALCysAALGLFVDhaPRYGGADhbWVVLAVAALLVWQGLVLRRRRDhbGPADhaQDhb

antiSMASH-DB 4.0 matches for H9624_RS14910

100.0%

NZ_JACSPO010000013.1and 1 other:

NZ_JACSPO010000013.1 Lanthipeptides: H9624_RS14910_lanthipeptide

Lanthipeptides: H9624_RS14910_lanthipeptide

1

ALCAALGLFVSPRYGGATWVVLAVAALLVWQGLVLRRRRTGPASQT

46

ALCAALGLFVSPRYGGATWVVLAVAALLVWQGLVLRRRRTGPASQT

1

ALCAALGLFVSPRYGGATWVVLAVAALLVWQGLVLRRRRTGPASQT

46

21.7%

NZ_AKXV01000031.1and 1 other:

NZ_AKXV01000031.1 Lanthipeptides: Y19_RS44045_lanthipeptide

Lanthipeptides: Y19_RS44045_lanthipeptide

14

YGGATW---VVLAVAALL

28

YGG TW +V AVA L+

15

YGGTTWSCAIVTAVATLV

32

15.7%

NZ_BMSB01000008.1:

Lanthipeptides: allorf_182878_183105_lanthipeptide

27

LLVWQGLVLRRRRTGPASQT

46

L+ W G R R T P + T

5

LIGWAGQPCRSRSTAPGTNT

24

MIBiG 4.0 matches for H9624_RS14910

8.7%

BGC0000563.4 (AEA03263.1):

Lanthipeptide: venezuelin

1

ALCAALGLF

9

A C +GL

1

ATCECVGLL

9

8.7%

BGC0001889.2 (fusA):

Lasso peptide: fusilassin

8

LFVSPRY

14

+FV PR+

11

IFVFPRF

17

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (4):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.26 out of 30.22

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 20.37 out of 35.63

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.74 out of 23.43

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.23 out of 26.85

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

H9624_RS14865 - Class II

Cleavage pHMM score: -1.20

RODEO score: 0

Monoisotopic mass: 5029.7 Da

Molecular weight: 5032.8 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 5050.8 Da N = 1; 5068.8 Da N = 2; 5086.8 Da N = 3; 5104.8 Da N = 4; 5122.9 Da N = 5

H9624_RS14885 - Class II

Cleavage pHMM score: -3.90

RODEO score: 0

Monoisotopic mass: 3068.5 Da

Molecular weight: 3070.6 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3088.6 Da N = 1; 3106.6 Da N = 2; 3124.6 Da N = 3

H9624_RS14910 - Class II

Cleavage pHMM score: -4.50

RODEO score: 0

Monoisotopic mass: 4773.7 Da

Molecular weight: 4776.6 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 4794.7 Da N = 1; 4812.7 Da N = 2; 4830.7 Da N = 3; 4848.7 Da N = 4

H9624_RS14865 - Class II

Cleavage pHMM score: -1.20

RODEO score: 0

Monoisotopic mass: 5029.7 Da

Molecular weight: 5032.8 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 5050.8 Da N = 1; 5068.8 Da N = 2; 5086.8 Da N = 3; 5104.8 Da N = 4; 5122.9 Da N = 5

H9624_RS14885 - Class II

Cleavage pHMM score: -3.90

RODEO score: 0

Monoisotopic mass: 3068.5 Da

Molecular weight: 3070.6 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3088.6 Da N = 1; 3106.6 Da N = 2; 3124.6 Da N = 3

H9624_RS14910 - Class II

Cleavage pHMM score: -4.50

RODEO score: 0

Monoisotopic mass: 4773.7 Da

Molecular weight: 4776.6 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 4794.7 Da N = 1; 4812.7 Da N = 2; 4830.7 Da N = 3; 4848.7 Da N = 4

TFBS definitions

Regulator	Description

NZ_JACSPO010000014.1 - Region 1 - terpene-precursor

Download region GenBank file

Download region SVG

Location: 6,385 - 27,491 nt. (total: 21,107 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: synthetase

H9624_RS15070: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002309.2	0.37	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000677.5	0.33	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0001911.3	0.30	terpene	raimonol	Streptomyces anulatus
BGC0000664.5	0.28	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000648.3	0.27	terpene	carotenoid	Myxococcus xanthus
BGC0000644.3	0.27	terpene	carotenoid	Dietzia sp. CQ4
BGC0000286.3	0.27	PKS	viguiepinol	Streptomyces sp. KO-3988
BGC0000665.5	0.26	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0000649.3	0.26	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000636.3	0.25	terpene	carotenoid	Brevibacterium linens

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002309.2	0.37	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000677.5	0.33	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0001911.3	0.30	terpene	raimonol	Streptomyces anulatus
BGC0000664.5	0.28	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000648.3	0.27	terpene	carotenoid	Myxococcus xanthus
BGC0000644.3	0.27	terpene	carotenoid	Dietzia sp. CQ4
BGC0000286.3	0.27	PKS	viguiepinol	Streptomyces sp. KO-3988
BGC0000665.5	0.26	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0000649.3	0.26	terpene	carotenoid	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000636.3	0.25	terpene	carotenoid	Brevibacterium linens

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

H9624_RS15070: PT_FPPS_like

Domain 1 (51 - 281): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.46 out of 23.05

Confidence: medium

Additional weak hits (1):

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.12 out of 36.53

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production

NZ_JACSPO010000001.1 - Region 1 - azole-containing-RiPP

Download region GenBank file

Download region SVG

Location: 345,433 - 368,784 nt. (total: 23,352 nt) Show pHMM detection rules used

azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Azole RiPPs

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: reductase

H9624_RS01665: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

Hydrolases: protease

H9624_RS01660: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001170.5	0.40	ribosomal	clostridiolysin S	Clostridium sporogenes ATCC 15579
BGC0000564.5	0.40	ribosomal	clostridiolysin S	Clostridium botulinum A str. ATCC 3502
BGC0002036.4	0.36	other (other)	dehydrofosmidomycin	Streptomyces lavendulae
BGC0000285.5	0.35	PKS, saccharide	flaviolin, flaviolin rhamnoside, 3,3'-diflaviolin	Saccharopolyspora erythraea
BGC0001002.5	0.33	NRPS, PKS	jawsamycin	Streptomyces roseoverticillatus
BGC0001637.3	0.31	NRPS	kleboxymycin	Klebsiella oxytoca
BGC0001228.5	0.31	NRPS	retimycin A	Salinispora arenicola CNT005
BGC0000415.5	0.31	NRPS	quinomycin	Streptomyces griseovariabilis subsp. bandungensis
BGC0000448.5	0.30	NRPS	tomaymycin	Streptomyces achromogenes
BGC0000339.5	0.30	NRPS	echinomycin	Streptomyces lasaliensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001170.5	0.40	ribosomal	clostridiolysin S	Clostridium sporogenes ATCC 15579
BGC0000564.5	0.40	ribosomal	clostridiolysin S	Clostridium botulinum A str. ATCC 3502
BGC0002036.4	0.36	other (other)	dehydrofosmidomycin	Streptomyces lavendulae
BGC0000285.5	0.35	PKS, saccharide	flaviolin, flaviolin rhamnoside, 3,3'-diflaviolin	Saccharopolyspora erythraea
BGC0001002.5	0.33	NRPS, PKS	jawsamycin	Streptomyces roseoverticillatus
BGC0001637.3	0.31	NRPS	kleboxymycin	Klebsiella oxytoca
BGC0001228.5	0.31	NRPS	retimycin A	Salinispora arenicola CNT005
BGC0000415.5	0.31	NRPS	quinomycin	Streptomyces griseovariabilis subsp. bandungensis
BGC0000448.5	0.30	NRPS	tomaymycin	Streptomyces achromogenes
BGC0000339.5	0.30	NRPS	echinomycin	Streptomyces lasaliensis

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.63 out of 18.46

Confidence: medium

Additional weak hits (4):

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.13 out of 25.75

Confidence: weak

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.17 out of 26.85

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.26 out of 30.22

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 19.54 out of 27.04

Confidence: weak

(Thi)azol(in)e containing peptide predictions

No core peptides found.

TFBS Finder

Azole RiPPs

TFBS definitions

Regulator	Description
RpoN	Regulator of nitrogen assimilation and virulence

Core peptide predictions

No core peptides found.

NZ_JACSPO010000001.1 - Region 2 - terpene-precursor

Download region GenBank file

Download region SVG

Location: 500,141 - 521,220 nt. (total: 21,080 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

H9624_RS02360: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Ligases: synthetase

H9624_RS02395: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000677.5	0.42	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0002404.2	0.41	other (other)	falcarindiol	Solanum lycopersicum
BGC0001910.4	0.39	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0001456.3	0.39	terpene	isorenieratene	Streptomyces argillaceus
BGC0000664.5	0.38	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001911.3	0.38	terpene	raimonol	Streptomyces anulatus
BGC0001227.3	0.38	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000633.3	0.37	terpene	carotenoid	Streptomyces avermitilis
BGC0002309.2	0.37	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0001521.3	0.37	NRPS	auriculamide	Herpetosiphon aurantiacus DSM 785

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000677.5	0.42	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0002404.2	0.41	other (other)	falcarindiol	Solanum lycopersicum
BGC0001910.4	0.39	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus
BGC0001456.3	0.39	terpene	isorenieratene	Streptomyces argillaceus
BGC0000664.5	0.38	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001911.3	0.38	terpene	raimonol	Streptomyces anulatus
BGC0001227.3	0.38	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000633.3	0.37	terpene	carotenoid	Streptomyces avermitilis
BGC0002309.2	0.37	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0001521.3	0.37	NRPS	auriculamide	Herpetosiphon aurantiacus DSM 785

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

H9624_RS02395: PT_FPPS_like

Domain 1 (45 - 357): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.26 out of 19.26

Confidence: medium

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 23.42 out of 27.18

Confidence: medium

Additional weak hits (7):

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.30 out of 21.84

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.87 out of 28.14

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 16.54 out of 30.97

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.10 out of 28.14

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 18.55 out of 30.97

Confidence: weak

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 20.12 out of 27.18

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.72 out of 28.19

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
NrdR	Represses ribonucleotide reductase encoding genes

NZ_JACSPO010000001.1 - Region 3 - lanthipeptide-class-v

Download region GenBank file

Download region SVG

Location: 696,669 - 738,674 nt. (total: 42,006 nt) Show pHMM detection rules used

lanthipeptide-class-v: (APH and HopA1)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

H9624_RS03240: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

H9624_RS03380: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

Hydrolases: hydrolase protease

H9624_RS03285: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

H9624_RS03310: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

H9624_RS03340: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase dehydratase

H9624_RS03325: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

H9624_RS03360: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Translocases: transporter

H9624_RS03245: sugar-binding lipoprotein

smcogs: SMCOG1143: sugar-binding lipoprotein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000622.5	0.50	ribosomal	megacin	Bacillus megaterium
BGC0000503.5	0.48	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0002346.3	0.48	ribosomal	kyamicin	Saccharopolyspora sp.
BGC0000551.5	0.46	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000528.5	0.46	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0002316.2	0.45	ribosomal	cebulantin	Saccharopolyspora cebuensis
BGC0000518.3	0.43	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0001374.5	0.43	other (other)	thienodolin	Streptomyces albogriseolus
BGC0002629.2	0.43	ribosomal	limnothamide	Limnothrix sp. CACIAM 69d
BGC0000874.5	0.42	other (other)	blasticidin S	Streptomyces griseochromogenes

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000622.5	0.50	ribosomal	megacin	Bacillus megaterium
BGC0000503.5	0.48	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0002346.3	0.48	ribosomal	kyamicin	Saccharopolyspora sp.
BGC0000551.5	0.46	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000528.5	0.46	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0002316.2	0.45	ribosomal	cebulantin	Saccharopolyspora cebuensis
BGC0000518.3	0.43	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0001374.5	0.43	other (other)	thienodolin	Streptomyces albogriseolus
BGC0002629.2	0.43	ribosomal	limnothamide	Limnothrix sp. CACIAM 69d
BGC0000874.5	0.42	other (other)	blasticidin S	Streptomyces griseochromogenes

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptides - No core peptides found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.73 out of 23.79

Confidence: medium

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 19.52 out of 19.52

Confidence: strong

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 18.42 out of 19.52

Confidence: strong

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 24.24 out of 29.65

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.98 out of 24.78

Confidence: medium

Additional weak hits (2):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.45 out of 30.25

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 23.84 out of 30.22

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

No core peptides found.

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
IolR	Regulator of the inositol catabolism
LexA variant 1	Repressor of DNA damage response
LexA variant 2	Repressor of DNA damage response

NZ_JACSPO010000001.1 - Region 4 - lassopeptide

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Location: 977,407 - 1,002,117 nt. (total: 24,711 nt) Show pHMM detection rules used

lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene/CDS overview

Filter:

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: hydrolase

H9624_RS04520: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

H9624_RS04540: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000571.3	0.49	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454
BGC0002064.2	0.45	ribosomal	felipeptin A2, felipeptin A1	Amycolatopsis sp. YIM 10
BGC0002306.2	0.43	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0001229.4	0.42	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000517.4	0.41	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0000504.5	0.41	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000538.3	0.40	ribosomal	nisin Z	Lactococcus lactis
BGC0002144.3	0.40	ribosomal	phazolicin	Rhizobium sp. Pop5
BGC0000619.3	0.40	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001388.3	0.40	ribosomal	gassericin E	Lactobacillus gasseri

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000571.3	0.49	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454
BGC0002064.2	0.45	ribosomal	felipeptin A2, felipeptin A1	Amycolatopsis sp. YIM 10
BGC0002306.2	0.43	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0001229.4	0.42	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000517.4	0.41	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0000504.5	0.41	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000538.3	0.40	ribosomal	nisin Z	Lactococcus lactis
BGC0002144.3	0.40	ribosomal	phazolicin	Rhizobium sp. Pop5
BGC0000619.3	0.40	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001388.3	0.40	ribosomal	gassericin E	Lactobacillus gasseri

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lasso peptide predictions

Lassopeptides - No core peptides found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.80 out of 23.79

Confidence: medium

Additional weak hits (4):

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 17.25 out of 24.78

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.86 out of 19.52

Confidence: weak

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.28 out of 19.26

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.44 out of 28.19

Confidence: weak

Lasso peptides

RREFinder

TFBS Finder

Core peptide predictions

No core peptides found.

RRE predictions

: RRE type: Stand_Alone_Lasso_RRE; Location: 4 - 82; Score: 62.8

TFBS definitions

Regulator	Description
IolR	Regulator of the inositol catabolism

NZ_JACSPO010000002.1 - Region 1 - T3PKS

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Location: 272,713 - 300,332 nt. (total: 27,620 nt) Show pHMM detection rules used

Region on contig edge.

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

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NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

H9624_RS07525: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

H9624_RS07555: oxidoreductase

smcogs: SMCOG1161: oxidoreductase

Transferases: aminotransferase methyltransferase

H9624_RS07550: Methylation

MITE: MITE0000155Methylation (identity: 70.30%)
smcogs: SMCOG1150: isoprenylcysteine carboxyl methyltransferase

H9624_RS07570: aminotransferase class V

smcogs: SMCOG1139: aminotransferase class V

Hydrolases: hydrolase

H9624_RS07490: HAD-superfamily hydrolase, subfamily IA, variant

smcogs: SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

Ligases: synthase

H9624_RS07545: chalcone and stilbene synthase domain protein

smcogs: SMCOG1024: chalcone and stilbene synthase domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000282.3	0.74	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3	0.51	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001077.4	0.46	PKS	6-anteisoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-geranyl-2-methoxyhydroquinone, 6-palmityl-4-O-geranyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-palmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone	Actinoplanes missouriensis 431
BGC0002362.3	0.42	PKS	loseolamycin A1, loseolamycin A2	Micromonospora endolithica
BGC0002447.3	0.39	ribosomal	cerecyclin	Bacillus cereus
BGC0001909.3	0.38	PKS	strobilurin A	Strobilurus tenacellus
BGC0000487.5	0.38	ribosomal	carnocyclin	Carnobacterium maltaromaticum
BGC0002567.2	0.38	other (other)	EDHA	Streptomyces sp. MA5143a
BGC0001285.5	0.38	other (fatty acid)	pseudopyronine A, pseudopyronine B	Pseudomonas putida
BGC0002666.2	0.38	NRPS, other (other)	Legonmycin A, Legonmycin B, Legonindolizine A, Legonindolizine B	Streptomyces sp. MA37

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000282.3	0.74	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3	0.51	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0001077.4	0.46	PKS	6-anteisoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-geranyl-2-methoxyhydroquinone, 6-palmityl-4-O-geranyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-palmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone	Actinoplanes missouriensis 431
BGC0002362.3	0.42	PKS	loseolamycin A1, loseolamycin A2	Micromonospora endolithica
BGC0002447.3	0.39	ribosomal	cerecyclin	Bacillus cereus
BGC0001909.3	0.38	PKS	strobilurin A	Strobilurus tenacellus
BGC0000487.5	0.38	ribosomal	carnocyclin	Carnobacterium maltaromaticum
BGC0002567.2	0.38	other (other)	EDHA	Streptomyces sp. MA5143a
BGC0001285.5	0.38	other (fatty acid)	pseudopyronine A, pseudopyronine B	Pseudomonas putida
BGC0002666.2	0.38	NRPS, other (other)	Legonmycin A, Legonmycin B, Legonindolizine A, Legonindolizine B	Streptomyces sp. MA37

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05

Confidence: medium

Additional weak hits (1):

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.27 out of 20.01

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production

NZ_JACSPO010000004.1 - Region 1 - terpene

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Location: 18,535 - 42,695 nt. (total: 24,161 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

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other genes

resistance

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KnownClusterBlast

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Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

H9624_RS09070: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

Ligases: synthase synthetase

H9624_RS09060: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

H9624_RS09095: polyprenol-monophosphomannose synthase ppm1

smcogs: SMCOG1123: polyprenol-monophosphomannose synthase ppm1

Translocases: transport

H9624_RS09045: MMPL domain-containing transport protein

smcogs: SMCOG1035: MMPL domain-containing transport protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000644.3	0.71	terpene	carotenoid	Dietzia sp. CQ4
BGC0000637.3	0.63	terpene	carotenoid	Corynebacterium glutamicum
BGC0000650.3	0.59	terpene	carotenoid	Algoriphagus sp. KK10202C
BGC0000648.3	0.55	terpene	carotenoid	Myxococcus xanthus
BGC0000656.5	0.50	terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0000636.3	0.50	terpene	carotenoid	Brevibacterium linens
BGC0000664.5	0.48	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002400.2	0.48	terpene	boleracene	Brassica oleracea var. oleracea
BGC0001456.3	0.48	terpene	isorenieratene	Streptomyces argillaceus
BGC0001227.3	0.47	terpene	isorenieratene	Streptomyces collinus Tu 365

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000644.3	0.71	terpene	carotenoid	Dietzia sp. CQ4
BGC0000637.3	0.63	terpene	carotenoid	Corynebacterium glutamicum
BGC0000650.3	0.59	terpene	carotenoid	Algoriphagus sp. KK10202C
BGC0000648.3	0.55	terpene	carotenoid	Myxococcus xanthus
BGC0000656.5	0.50	terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0000636.3	0.50	terpene	carotenoid	Brevibacterium linens
BGC0000664.5	0.48	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002400.2	0.48	terpene	boleracene	Brassica oleracea var. oleracea
BGC0001456.3	0.48	terpene	isorenieratene	Streptomyces argillaceus
BGC0001227.3	0.47	terpene	isorenieratene	Streptomyces collinus Tu 365

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
tetraterpene	C40 carotenoid		C40	unknown	unknown

Genes with terpene domains:

H9624_RS09060: PT_FPPS_like

Domain 1 (44 - 329): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

H9624_RS09065: PT_phytoene_like

Domain 1 (26 - 281): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → diapophytoene; FPP → PSPP; FPP → squalene; GGPP → phytoene; PSPP → hydroxysqualene

H9624_RS09075: Lycopene_cycl

Domain 1 (4 - 92): Lycopene cyclase

Reactions:: C40_carotenoid → C40_carotenoid

H9624_RS09080: Lycopene_cycl

Domain 1 (1 - 93): Lycopene cyclase

Reactions:: C40_carotenoid → C40_carotenoid

Transcription Factor Binding Sites

Binding sites found:

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 30.47 out of 36.53

Confidence: medium

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 19.52 out of 19.52

Confidence: strong

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 18.42 out of 19.52

Confidence: strong

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.88 out of 20.47

Confidence: medium

Additional weak hits (5):

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.88 out of 25.75

Confidence: weak

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 13.03 out of 18.57

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.51 out of 21.55

Confidence: weak

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.34 out of 28.19

Confidence: weak

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 17.99 out of 25.31

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description
AfsQ1	Two-component system AfsQ1-Q2, activator of antibiotic production
DmdR1	Iron(II)-dependent repressor
VqsM	Regulator of quorum-sensing signalling systems

NZ_JACSPO010000008.1 - Region 1 - ectoine

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Location: 38,434 - 48,823 nt. (total: 10,390 nt) Show pHMM detection rules used

ectoine: ectoine_synt

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

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SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: aminotransferase

H9624_RS12720: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Hydrolases: deacetylase

H9624_RS12695: acetylornithine deacetylase

smcogs: SMCOG1247: acetylornithine deacetylase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000855.3	0.72	other (other)	ectoine	Methylomicrobium kenyense
BGC0000859.3	0.72	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0000852.5	0.70	other (other)	ectoine	Sporosarcina pasteurii
BGC0002052.3	0.70	other (ectoine)	ectoine	Streptomyces sp.
BGC0000853.3	0.69	other (other)	ectoine	Streptomyces anulatus
BGC0000858.3	0.66	other (other)	ectoine	Methylobacter marinus
BGC0000857.3	0.64	other (other)	ectoine	Methylophaga alcalica
BGC0000860.3	0.60	other (other)	ectoine	Methylarcula marina
BGC0000854.3	0.58	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z
BGC0000856.3	0.55	other (other)	ectoine	Methylophaga thalassica

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000855.3	0.72	other (other)	ectoine	Methylomicrobium kenyense
BGC0000859.3	0.72	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0000852.5	0.70	other (other)	ectoine	Sporosarcina pasteurii
BGC0002052.3	0.70	other (ectoine)	ectoine	Streptomyces sp.
BGC0000853.3	0.69	other (other)	ectoine	Streptomyces anulatus
BGC0000858.3	0.66	other (other)	ectoine	Methylobacter marinus
BGC0000857.3	0.64	other (other)	ectoine	Methylophaga alcalica
BGC0000860.3	0.60	other (other)	ectoine	Methylarcula marina
BGC0000854.3	0.58	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z
BGC0000856.3	0.55	other (other)	ectoine	Methylophaga thalassica

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (1):

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.19 out of 26.85

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description