Select genomic region:
Overview
4.1
5.1
11.1
11.2
11.3
11.4
20.1
22.1
26.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_JACSPO010000013.1 (Oceanitalea stevensii)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 4.1 | lanthipeptide-class-ii | 18,061 | 44,264 |

NZ_JACSPO010000014.1 (Oceanitalea stevensii)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 5.1 | terpene-precursor | 6,385 | 27,491 | Low | CDA1b/CDA2a/CDA2b/CDA3a/CDA3b/CDA4a/CDA4b | NRPS:Type I

NZ_JACSPO010000001.1 (Oceanitalea stevensii)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 11.1 | azole-containing-RiPP | 345,433 | 368,784 |
Region 11.2 | terpene-precursor | 500,141 | 521,220 |
Region 11.3 | lanthipeptide-class-v | 696,669 | 738,674 |
Region 11.4 | lassopeptide | 977,407 | 1,002,117 |

NZ_JACSPO010000002.1 (Oceanitalea stevensii)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 20.1 | T3PKS | 272,713 | 300,332 | High | 2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone/2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol | PKS:Type III

NZ_JACSPO010000004.1 (Oceanitalea stevensii)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 22.1 | terpene | 18,535 | 42,695 | Medium | carotenoid | terpene

NZ_JACSPO010000008.1 (Oceanitalea stevensii)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 26.1 | ectoine | 38,434 | 48,823 | Medium | ectoine | other:ectoine

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 4.1 | lanthipeptide-class-ii | 18,061 | 44,264 |
Region 5.1 | terpene-precursor | 6,385 | 27,491 | Low | CDA1b/CDA2a/CDA2b/CDA3a/CDA3b/CDA4a/CDA4b | NRPS:Type I
Region 11.1 | azole-containing-RiPP | 345,433 | 368,784 |
Region 11.2 | terpene-precursor | 500,141 | 521,220 |
Region 11.3 | lanthipeptide-class-v | 696,669 | 738,674 |
Region 11.4 | lassopeptide | 977,407 | 1,002,117 |
Region 20.1 | T3PKS | 272,713 | 300,332 | High | 2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone/2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol | PKS:Type III
Region 22.1 | terpene | 18,535 | 42,695 | Medium | carotenoid | terpene
Region 26.1 | ectoine | 38,434 | 48,823 | Medium | ectoine | other:ectoine

No secondary metabolite regions were found in these records:
  NZ_JACSPO010000010.1 (Oceanitalea stevensii)
  NZ_JACSPO010000011.1 (Oceanitalea stevensii)
  NZ_JACSPO010000012.1 (Oceanitalea stevensii)
  NZ_JACSPO010000015.1 (Oceanitalea stevensii)
  NZ_JACSPO010000016.1 (Oceanitalea stevensii)
  NZ_JACSPO010000017.1 (Oceanitalea stevensii)
  NZ_JACSPO010000018.1 (Oceanitalea stevensii)
  NZ_JACSPO010000019.1 (Oceanitalea stevensii)
  NZ_JACSPO010000020.1 (Oceanitalea stevensii)
  NZ_JACSPO010000021.1 (Oceanitalea stevensii)
  NZ_JACSPO010000022.1 (Oceanitalea stevensii)
  NZ_JACSPO010000023.1 (Oceanitalea stevensii)
  NZ_JACSPO010000024.1 (Oceanitalea stevensii)
  NZ_JACSPO010000025.1 (Oceanitalea stevensii)
  NZ_JACSPO010000026.1 (Oceanitalea stevensii)
  NZ_JACSPO010000027.1 (Oceanitalea stevensii)
  NZ_JACSPO010000003.1 (Oceanitalea stevensii)
  NZ_JACSPO010000005.1 (Oceanitalea stevensii)
  NZ_JACSPO010000006.1 (Oceanitalea stevensii)
  NZ_JACSPO010000007.1 (Oceanitalea stevensii)
  NZ_JACSPO010000009.1 (Oceanitalea stevensii)

Compact view
NZ_JACSPO010000013.1 - Region 1 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 18,061 - 44,264 nt. (total: 26,204 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
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Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: cyclase
H9624_RS14880: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

H9624_RS14890: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Isomerases: mutase
H9624_RS14930: phosphoglycerate mutase

smcogs
  SMCOG1101: phosphoglycerate mutase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001229.4 |  | 0.61 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0002110.3 |  | 0.60 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0000520.5 |  | 0.55 | ribosomal | lacticin 3147 A1, lacticin 3147 A2 | Lactococcus lactis
BGC0000503.5 |  | 0.54 | ribosomal | cinnamycin | Streptomyces cinnamoneus
BGC0000623.3 |  | 0.53 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000554.4 |  | 0.51 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000517.4 |  | 0.51 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0002005.2 |  | 0.51 | ribosomal | RaxX | Xanthomonas oryzae pv. oryzae
BGC0001391.3 |  | 0.51 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni
BGC0002346.3 |  | 0.50 | ribosomal | kyamicin | Saccharopolyspora sp.

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001229.4 |  | 0.61 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0002110.3 |  | 0.60 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0000520.5 |  | 0.55 | ribosomal | lacticin 3147 A1, lacticin 3147 A2 | Lactococcus lactis
BGC0000503.5 |  | 0.54 | ribosomal | cinnamycin | Streptomyces cinnamoneus
BGC0000623.3 |  | 0.53 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000554.4 |  | 0.51 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000517.4 |  | 0.51 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0002005.2 |  | 0.51 | ribosomal | RaxX | Xanthomonas oryzae pv. oryzae
BGC0001391.3 |  | 0.51 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni
BGC0002346.3 |  | 0.50 | ribosomal | kyamicin | Saccharopolyspora sp.

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for H9624_RS14880

H9624_RS14865
Leader:
MRLRRIAAA
Core:
S L V L S A T V V L G P P A L A A D T G T A V R A A S P P V A E P A T F L G D L A C Q V L G D F F E K C
Core with dehydrations:
Dha L V L Dha A Dhb V V L G P P A L A A D Dhb G Dhb A V R A A Dha P P V A E P A Dhb F L G D L A Cys Q V L G D F F E K Cys

#### antiSMASH-DB 4.0 matches for H9624_RS14865

100.0%
NZ_JACSPO010000013.1 and 1 other:
NZ_JACSPO010000013.1 Lanthipeptides: H9624_RS14865_lanthipeptide
Lanthipeptides: H9624_RS14865_lanthipeptide
1
S L V L S A T V V L G P P A L A A D T G T A V R A A S P P V A E P A T F L G D L A C Q V L G D F F E K C
52
S L V L S A T V V L G P P A L A A D T G T A V R A A S P P V A E P A T F L G D L A C Q V L G D F F E K C
1
S L V L S A T V V L G P P A L A A D T G T A V R A A S P P V A E P A T F L G D L A C Q V L G D F F E K C
52
19.2%
NZ_CP070496.1:
Lanthipeptides: allorf_3787427_3787648_lanthipeptide
27
S P P V A E P---A T F L G D L A C Q V L G D F F E K C
52
P P + P F G++A C V F C
19
Q P P G S S P R A R G A F T G E V A C D V A V G F I P A C
47
17.3%
NZ_NNBN01000001.1 and 1 other:
NZ_NNBN01000001.1 Lanthipeptides: allorf_771486_771668_lanthipeptide
Lanthipeptides: allorf_771486_771668_lanthipeptide
15
L A A D T G T A V R A A S P P V A E P A
34
+A A T G A V A + + P A
20
I A A S T G R A V S A R T T E I R N P A
39
with 1 more sequence matches
11.5%
NZ_CP030771.1:
Lanthipeptides: allorf_09785478_09785648_lanthipeptide
44
V L G D F F E K C
52
V L D F K C
16
V L N D H F R K C
24
H9624_RS14885
Leader:
MFTTRDYTRANGYVSDAELVELTEDTVVDAA
Core:
A G T T T V P C A I G G G V I A I S A A L P D F C P T G A C T T R C
Core with dehydrations:
A G Dhb Dhb Dhb V P Cys A I G G G V I A I Dha A A L P D F Cys P Dhb G A Cys Dhb Dhb R Cys

#### antiSMASH-DB 4.0 matches for H9624_RS14885

100.0%
NZ_JACSPO010000013.1 and 1 other:
NZ_JACSPO010000013.1 Lanthipeptides: H9624_RS14885_lanthipeptide
Lanthipeptides: H9624_RS14885_lanthipeptide
1
A G T T T V P C A I G G G V I A I S A A L P D F C P T G A C T T R C
34
A G T T T V P C A I G G G V I A I S A A L P D F C P T G A C T T R C
1
A G T T T V P C A I G G G V I A I S A A L P D F C P T G A C T T R C
34
68.6%
NZ_JALGRP010000007.1 and 1 other:
NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12965_lanthipeptide
Lanthipeptides: MT347_RS12965_lanthipeptide
3
T T T V P C A I G G G V I A I S A A L P D F C P T G A C T T R C
34
T T T P C A+ G I A +A A L P F C P T G A C T T R C
1
T T T A P C A V A G L T I A A T A A L P G F C P T G A C T T R C
32
52.9%
NZ_NTSF01000026.1 and 1 other:
NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21840_lanthipeptide
Lanthipeptides: CN325_RS21840_lanthipeptide
3
T T T V P C A I G G G V I A I S A A L P D F C P T G A C T T R C
34
+T T V P C I G I I S A +C P T C T R C
2
S T T V P C G I-G S T I T I S I A---Y C P T S K C T E R C
29
with 113 more sequence matches
Only the first 10 are displayed here.
46.2%
NZ_VTZW01000015.1 and 1 other:
NZ_VTZW01000015.1 Lanthipeptides: FZ103_RS15840_lanthipeptide
Lanthipeptides: FZ103_RS15840_lanthipeptide
3
T T T V P C---A I G G G V I A I S A A L P D F C P T G A C T T R C
34
+T T V C A+ + A S A A+ D C P T A C T T C
5
S T T V V C G I S A V T S A I T A A S A A M G D N C P T T A C T T Y C
39
41.2%
NZ_CP013862.1 and 1 other:
NZ_CP013862.1 Lanthipeptides: AOX59_RS09365_lanthipeptide
Lanthipeptides: AOX59_RS09365_lanthipeptide
5
T V P C A I G G G V I A I S A A L P D F C P T G A C T T R C
34
T P ++ G I A+S A F C P T C T++C
7
T T P S S V A C G-I A V S A L---F C P T T K C T S Q C
32
41.2%
NZ_FQZK01000006.1 and 2 others:
NZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13105_lanthipeptide NZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13105_lanthipeptide
Lanthipeptides: BUE45_RS13105_lanthipeptide
12
G G V I A I S A A L P D F C P T G A C T T R C
34
V A I S A A D C P T C T+R C
6
A S V T A I S A A W G D G C P T T V C T S R C
28
41.2%
NZ_LT630004.1:
Lanthipeptides: BQ5796_RS18310_lanthipeptide
3
T T T V P C A I G G G V I A I S A A L P D F C P T G A C T T R C
34
T T T+P C G + I S ++ C P T C T++C
1
T T T L P C V--G I T V T I S V S M---C P T T K C T S Q C
27
41.2%
NZ_QKTG01000020.1 and 1 other:
NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS08060_lanthipeptide
Lanthipeptides: DEI99_RS08060_lanthipeptide
18
S A A L P D F C P T G A C T T R C
34
S A A L P F C P T G A C T++C
1
S A A L P G F C P T G A C T S K C
17
40.5%
NZ_CM000756.1 and 17 others:
NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptide NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14765_lanthipeptide NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptide
Lanthipeptides: BTHUR0011_RS14765_lanthipeptide
1
A G T T T V P C A I G G G V I A I S A A L P D F C P T G A C T T R C
34
A G T + A I V A++A P C P T A C+ C
5
A G T P A I V T A I S A-V T A V T A Q S P--C P T S A C S K S C
35
40.5%
NZ_NTSR01000029.1 and 1 other:
NZ_NTSR01000029.1 Lanthipeptides: CN358_RS25165_lanthipeptide
Lanthipeptides: CN358_RS25165_lanthipeptide
4
T T V P C A I G G G V I A I S A A L P D F----C P T G A C T T R C
34
T T V P C A+G G + I+ D C P T A C++R C
7
T T V P C A V G G A T V G I T I Y T F D R S H Q S C P T S A C S S R C
41
38.5%
NZ_BLIS01000009.1 and 5 others:
NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04825_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptide
Lanthipeptides: GVO03_RS04825_lanthipeptide
9
A I G G G V I A I S A A L P-D F C P T G A C T T R C
34
A I G G V I A++A + + C P T A C T C
13
A I G K G V I A V T A F V S A N T C P T S A C T R A C
39
38.5%
NZ_CP009280.1 and 1 other:
NZ_CP009280.1 Lanthipeptides: P40081_RS37160_lanthipeptide
Lanthipeptides: P40081_RS37160_lanthipeptide
3
T T T V P C A I G G G V I A I S A A L P D F C P T G A C T T R C
34
T++ P C I G + I S A L C P T C T++C
13
T S S W P C V I G A--V D I S A N L---C P T T K C T S K C
39
38.2%
NZ_CP017762.1 and 3 others:
NZ_CP017762.1 Lanthipeptides: BKP57_RS21840_lanthipeptide NZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptide NZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptide
Lanthipeptides: BKP57_RS21840_lanthipeptide
3
T T T V P C A I G G G V I A I S A A L P D F C P T G A C T T R C
34
T T T V P C A+ + C P T A C+++C
1
T T T V P C A V A A S I--------A L C P T L A C S S K C
24

#### MIBiG 4.0 matches for H9624_RS14885

40.5%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
9
A I G G G V-I A I S A A L P D F C P T G A C T T R C
34
A I G V + +S A A F C P T C T+R C
14
A I Q A G V A V G V S A A---F C P T T K C T S R C
37
20.6%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
24
F C P T G A C T T R C
34
F C P T C T++C
16
F C P T T K C T S K C
26
H9624_RS14910
Leader:
MNQQARPGVSEIVTFAAA
Core:
A L C A A L G L F V S P R Y G G A T W V V L A V A A L L V W Q G L V L R R R R T G P A S Q T
Core with dehydrations:
A L Cys A A L G L F V Dha P R Y G G A Dhb W V V L A V A A L L V W Q G L V L R R R R Dhb G P A Dha Q Dhb

#### antiSMASH-DB 4.0 matches for H9624_RS14910

100.0%
NZ_JACSPO010000013.1 and 1 other:
NZ_JACSPO010000013.1 Lanthipeptides: H9624_RS14910_lanthipeptide
Lanthipeptides: H9624_RS14910_lanthipeptide
1
A L C A A L G L F V S P R Y G G A T W V V L A V A A L L V W Q G L V L R R R R T G P A S Q T
46
A L C A A L G L F V S P R Y G G A T W V V L A V A A L L V W Q G L V L R R R R T G P A S Q T
1
A L C A A L G L F V S P R Y G G A T W V V L A V A A L L V W Q G L V L R R R R T G P A S Q T
46
21.7%
NZ_AKXV01000031.1 and 1 other:
NZ_AKXV01000031.1 Lanthipeptides: Y19_RS44045_lanthipeptide
Lanthipeptides: Y19_RS44045_lanthipeptide
14
Y G G A T W---V V L A V A A L L
28
Y G G T W +V A V A L+
15
Y G G T T W S C A I V T A V A T L V
32
15.7%
NZ_BMSB01000008.1:
Lanthipeptides: allorf_182878_183105_lanthipeptide
27
L L V W Q G L V L R R R R T G P A S Q T
46
L+ W G R R T P + T
5
L I G W A G Q P C R S R S T A P G T N T
24

#### MIBiG 4.0 matches for H9624_RS14910

8.7%
BGC0000563.4 (AEA03263.1):
Lanthipeptide: venezuelin
1
A L C A A L G L F
9
A C +G L
1
A T C E C V G L L
9
8.7%
BGC0001889.2 (fusA):
Lasso peptide: fusilassin
8
L F V S P R Y
14
+F V P R+
11
I F V F P R F
17

#### Lanthipeptide(s) for H9624_RS14890

H9624_RS14865
Leader:
MRLRRIAAA
Core:
S L V L S A T V V L G P P A L A A D T G T A V R A A S P P V A E P A T F L G D L A C Q V L G D F F E K C
Core with dehydrations:
Dha L V L Dha A Dhb V V L G P P A L A A D Dhb G Dhb A V R A A Dha P P V A E P A Dhb F L G D L A Cys Q V L G D F F E K Cys

#### antiSMASH-DB 4.0 matches for H9624_RS14865

100.0%
NZ_JACSPO010000013.1 and 1 other:
NZ_JACSPO010000013.1 Lanthipeptides: H9624_RS14865_lanthipeptide
Lanthipeptides: H9624_RS14865_lanthipeptide
1
S L V L S A T V V L G P P A L A A D T G T A V R A A S P P V A E P A T F L G D L A C Q V L G D F F E K C
52
S L V L S A T V V L G P P A L A A D T G T A V R A A S P P V A E P A T F L G D L A C Q V L G D F F E K C
1
S L V L S A T V V L G P P A L A A D T G T A V R A A S P P V A E P A T F L G D L A C Q V L G D F F E K C
52
19.2%
NZ_CP070496.1:
Lanthipeptides: allorf_3787427_3787648_lanthipeptide
27
S P P V A E P---A T F L G D L A C Q V L G D F F E K C
52
P P + P F G++A C V F C
19
Q P P G S S P R A R G A F T G E V A C D V A V G F I P A C
47
17.3%
NZ_NNBN01000001.1 and 1 other:
NZ_NNBN01000001.1 Lanthipeptides: allorf_771486_771668_lanthipeptide
Lanthipeptides: allorf_771486_771668_lanthipeptide
15
L A A D T G T A V R A A S P P V A E P A
34
+A A T G A V A + + P A
20
I A A S T G R A V S A R T T E I R N P A
39
with 1 more sequence matches
11.5%
NZ_CP030771.1:
Lanthipeptides: allorf_09785478_09785648_lanthipeptide
44
V L G D F F E K C
52
V L D F K C
16
V L N D H F R K C
24
H9624_RS14885
Leader:
MFTTRDYTRANGYVSDAELVELTEDTVVDAA
Core:
A G T T T V P C A I G G G V I A I S A A L P D F C P T G A C T T R C
Core with dehydrations:
A G Dhb Dhb Dhb V P Cys A I G G G V I A I Dha A A L P D F Cys P Dhb G A Cys Dhb Dhb R Cys

#### antiSMASH-DB 4.0 matches for H9624_RS14885

100.0%
NZ_JACSPO010000013.1 and 1 other:
NZ_JACSPO010000013.1 Lanthipeptides: H9624_RS14885_lanthipeptide
Lanthipeptides: H9624_RS14885_lanthipeptide
1
A G T T T V P C A I G G G V I A I S A A L P D F C P T G A C T T R C
34
A G T T T V P C A I G G G V I A I S A A L P D F C P T G A C T T R C
1
A G T T T V P C A I G G G V I A I S A A L P D F C P T G A C T T R C
34
68.6%
NZ_JALGRP010000007.1 and 1 other:
NZ_JALGRP010000007.1 Lanthipeptides: MT347_RS12965_lanthipeptide
Lanthipeptides: MT347_RS12965_lanthipeptide
3
T T T V P C A I G G G V I A I S A A L P D F C P T G A C T T R C
34
T T T P C A+ G I A +A A L P F C P T G A C T T R C
1
T T T A P C A V A G L T I A A T A A L P G F C P T G A C T T R C
32
52.9%
NZ_NTSF01000026.1 and 1 other:
NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21840_lanthipeptide
Lanthipeptides: CN325_RS21840_lanthipeptide
3
T T T V P C A I G G G V I A I S A A L P D F C P T G A C T T R C
34
+T T V P C I G I I S A +C P T C T R C
2
S T T V P C G I-G S T I T I S I A---Y C P T S K C T E R C
29
with 113 more sequence matches
Only the first 10 are displayed here.
46.2%
NZ_VTZW01000015.1 and 1 other:
NZ_VTZW01000015.1 Lanthipeptides: FZ103_RS15840_lanthipeptide
Lanthipeptides: FZ103_RS15840_lanthipeptide
3
T T T V P C---A I G G G V I A I S A A L P D F C P T G A C T T R C
34
+T T V C A+ + A S A A+ D C P T A C T T C
5
S T T V V C G I S A V T S A I T A A S A A M G D N C P T T A C T T Y C
39
41.2%
NZ_CP013862.1 and 1 other:
NZ_CP013862.1 Lanthipeptides: AOX59_RS09365_lanthipeptide
Lanthipeptides: AOX59_RS09365_lanthipeptide
5
T V P C A I G G G V I A I S A A L P D F C P T G A C T T R C
34
T P ++ G I A+S A F C P T C T++C
7
T T P S S V A C G-I A V S A L---F C P T T K C T S Q C
32
41.2%
NZ_FQZK01000006.1 and 2 others:
NZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13105_lanthipeptide NZ_FQZK01000006.1 Lanthipeptides: BUE45_RS13105_lanthipeptide
Lanthipeptides: BUE45_RS13105_lanthipeptide
12
G G V I A I S A A L P D F C P T G A C T T R C
34
V A I S A A D C P T C T+R C
6
A S V T A I S A A W G D G C P T T V C T S R C
28
41.2%
NZ_LT630004.1:
Lanthipeptides: BQ5796_RS18310_lanthipeptide
3
T T T V P C A I G G G V I A I S A A L P D F C P T G A C T T R C
34
T T T+P C G + I S ++ C P T C T++C
1
T T T L P C V--G I T V T I S V S M---C P T T K C T S Q C
27
41.2%
NZ_QKTG01000020.1 and 1 other:
NZ_QKTG01000020.1 Lanthipeptides: DEI99_RS08060_lanthipeptide
Lanthipeptides: DEI99_RS08060_lanthipeptide
18
S A A L P D F C P T G A C T T R C
34
S A A L P F C P T G A C T++C
1
S A A L P G F C P T G A C T S K C
17
40.5%
NZ_CM000756.1 and 17 others:
NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptide NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14765_lanthipeptide NZ_CM000756.1 Lanthipeptides: BTHUR0011_RS14760_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29740_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29735_lanthipeptide NZ_CP031749.1 Lanthipeptides: DPQ26_RS29730_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS26900_lanthipeptide NZ_CP036071.1 Lanthipeptides: EXW41_RS26895_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS22545_lanthipeptide NZ_WBPC01000036.1 Lanthipeptides: F8159_RS22540_lanthipeptide
Lanthipeptides: BTHUR0011_RS14765_lanthipeptide
1
A G T T T V P C A I G G G V I A I S A A L P D F C P T G A C T T R C
34
A G T + A I V A++A P C P T A C+ C
5
A G T P A I V T A I S A-V T A V T A Q S P--C P T S A C S K S C
35
40.5%
NZ_NTSR01000029.1 and 1 other:
NZ_NTSR01000029.1 Lanthipeptides: CN358_RS25165_lanthipeptide
Lanthipeptides: CN358_RS25165_lanthipeptide
4
T T V P C A I G G G V I A I S A A L P D F----C P T G A C T T R C
34
T T V P C A+G G + I+ D C P T A C++R C
7
T T V P C A V G G A T V G I T I Y T F D R S H Q S C P T S A C S S R C
41
38.5%
NZ_BLIS01000009.1 and 5 others:
NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04825_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptide
Lanthipeptides: GVO03_RS04825_lanthipeptide
9
A I G G G V I A I S A A L P-D F C P T G A C T T R C
34
A I G G V I A++A + + C P T A C T C
13
A I G K G V I A V T A F V S A N T C P T S A C T R A C
39
38.5%
NZ_CP009280.1 and 1 other:
NZ_CP009280.1 Lanthipeptides: P40081_RS37160_lanthipeptide
Lanthipeptides: P40081_RS37160_lanthipeptide
3
T T T V P C A I G G G V I A I S A A L P D F C P T G A C T T R C
34
T++ P C I G + I S A L C P T C T++C
13
T S S W P C V I G A--V D I S A N L---C P T T K C T S K C
39
38.2%
NZ_CP017762.1 and 3 others:
NZ_CP017762.1 Lanthipeptides: BKP57_RS21840_lanthipeptide NZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptide NZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptide
Lanthipeptides: BKP57_RS21840_lanthipeptide
3
T T T V P C A I G G G V I A I S A A L P D F C P T G A C T T R C
34
T T T V P C A+ + C P T A C+++C
1
T T T V P C A V A A S I--------A L C P T L A C S S K C
24

#### MIBiG 4.0 matches for H9624_RS14885

40.5%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
9
A I G G G V-I A I S A A L P D F C P T G A C T T R C
34
A I G V + +S A A F C P T C T+R C
14
A I Q A G V A V G V S A A---F C P T T K C T S R C
37
20.6%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
24
F C P T G A C T T R C
34
F C P T C T++C
16
F C P T T K C T S K C
26
H9624_RS14910
Leader:
MNQQARPGVSEIVTFAAA
Core:
A L C A A L G L F V S P R Y G G A T W V V L A V A A L L V W Q G L V L R R R R T G P A S Q T
Core with dehydrations:
A L Cys A A L G L F V Dha P R Y G G A Dhb W V V L A V A A L L V W Q G L V L R R R R Dhb G P A Dha Q Dhb

#### antiSMASH-DB 4.0 matches for H9624_RS14910

100.0%
NZ_JACSPO010000013.1 and 1 other:
NZ_JACSPO010000013.1 Lanthipeptides: H9624_RS14910_lanthipeptide
Lanthipeptides: H9624_RS14910_lanthipeptide
1
A L C A A L G L F V S P R Y G G A T W V V L A V A A L L V W Q G L V L R R R R T G P A S Q T
46
A L C A A L G L F V S P R Y G G A T W V V L A V A A L L V W Q G L V L R R R R T G P A S Q T
1
A L C A A L G L F V S P R Y G G A T W V V L A V A A L L V W Q G L V L R R R R T G P A S Q T
46
21.7%
NZ_AKXV01000031.1 and 1 other:
NZ_AKXV01000031.1 Lanthipeptides: Y19_RS44045_lanthipeptide
Lanthipeptides: Y19_RS44045_lanthipeptide
14
Y G G A T W---V V L A V A A L L
28
Y G G T W +V A V A L+
15
Y G G T T W S C A I V T A V A T L V
32
15.7%
NZ_BMSB01000008.1:
Lanthipeptides: allorf_182878_183105_lanthipeptide
27
L L V W Q G L V L R R R R T G P A S Q T
46
L+ W G R R T P + T
5
L I G W A G Q P C R S R S T A P G T N T
24

#### MIBiG 4.0 matches for H9624_RS14910

8.7%
BGC0000563.4 (AEA03263.1):
Lanthipeptide: venezuelin
1
A L C A A L G L F
9
A C +G L
1
A T C E C V G L L
9
8.7%
BGC0001889.2 (fusA):
Lasso peptide: fusilassin
8
L F V S P R Y
14
+F V P R+
11
I F V F P R F
17

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
No hits above weak threshold.
Weak hits (4):
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.26 out of 30.22
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 20.37 out of 35.63
Confidence: weak
BldD
Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 18.74 out of 23.43
Confidence: weak
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.23 out of 26.85
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

H9624_RS14865 - Class II
  Cleavage pHMM score: -1.20
  RODEO score: 0
  Monoisotopic mass: 5029.7 Da
  Molecular weight: 5032.8 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    5050.8 Da N = 1
    5068.8 Da N = 2
    5086.8 Da N = 3
    5104.8 Da N = 4
    5122.9 Da N = 5
H9624_RS14885 - Class II
  Cleavage pHMM score: -3.90
  RODEO score: 0
  Monoisotopic mass: 3068.5 Da
  Molecular weight: 3070.6 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3088.6 Da N = 1
    3106.6 Da N = 2
    3124.6 Da N = 3
H9624_RS14910 - Class II
  Cleavage pHMM score: -4.50
  RODEO score: 0
  Monoisotopic mass: 4773.7 Da
  Molecular weight: 4776.6 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4794.7 Da N = 1
    4812.7 Da N = 2
    4830.7 Da N = 3
    4848.7 Da N = 4
H9624_RS14865 - Class II
  Cleavage pHMM score: -1.20
  RODEO score: 0
  Monoisotopic mass: 5029.7 Da
  Molecular weight: 5032.8 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    5050.8 Da N = 1
    5068.8 Da N = 2
    5086.8 Da N = 3
    5104.8 Da N = 4
    5122.9 Da N = 5
H9624_RS14885 - Class II
  Cleavage pHMM score: -3.90
  RODEO score: 0
  Monoisotopic mass: 3068.5 Da
  Molecular weight: 3070.6 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3088.6 Da N = 1
    3106.6 Da N = 2
    3124.6 Da N = 3
H9624_RS14910 - Class II
  Cleavage pHMM score: -4.50
  RODEO score: 0
  Monoisotopic mass: 4773.7 Da
  Molecular weight: 4776.6 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4794.7 Da N = 1
    4812.7 Da N = 2
    4830.7 Da N = 3
    4848.7 Da N = 4

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---

NZ_JACSPO010000014.1 - Region 1 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 6,385 - 27,491 nt. (total: 21,107 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Ligases: synthetase
H9624_RS15070: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002309.2 |  | 0.37 | terpene | cattleyene | Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000677.5 |  | 0.33 | terpene | cyclooctatin | Streptomyces melanosporofaciens
BGC0001911.3 |  | 0.30 | terpene | raimonol | Streptomyces anulatus
BGC0000664.5 |  | 0.28 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000648.3 |  | 0.27 | terpene | carotenoid | Myxococcus xanthus
BGC0000644.3 |  | 0.27 | terpene | carotenoid | Dietzia sp. CQ4
BGC0000286.3 |  | 0.27 | PKS | viguiepinol | Streptomyces sp. KO-3988
BGC0000665.5 |  | 0.26 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0000649.3 |  | 0.26 | terpene | carotenoid | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000636.3 |  | 0.25 | terpene | carotenoid | Brevibacterium linens

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002309.2 |  | 0.37 | terpene | cattleyene | Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000677.5 |  | 0.33 | terpene | cyclooctatin | Streptomyces melanosporofaciens
BGC0001911.3 |  | 0.30 | terpene | raimonol | Streptomyces anulatus
BGC0000664.5 |  | 0.28 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000648.3 |  | 0.27 | terpene | carotenoid | Myxococcus xanthus
BGC0000644.3 |  | 0.27 | terpene | carotenoid | Dietzia sp. CQ4
BGC0000286.3 |  | 0.27 | PKS | viguiepinol | Streptomyces sp. KO-3988
BGC0000665.5 |  | 0.26 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0000649.3 |  | 0.26 | terpene | carotenoid | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000636.3 |  | 0.25 | terpene | carotenoid | Brevibacterium linens

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP
diterpene precursor |  | GGPP | C20 | acyclic | PP
sesterterpene precursor |  | GFPP | C25 | acyclic | PP
triterpene precursor |  | HPP | C30 | acyclic | PP

Genes with terpene domains:
H9624_RS15070: PT_FPPS_like
Domain 1 (51 - 281): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: unknown

Reactions:
  IPP, DMAPP → FPP
  IPP, DMAPP → GGPP
  IPP, DMAPP → GFPP
  IPP, DMAPP → HPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 18.46 out of 23.05
Confidence: medium
Additional weak hits (1):
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.12 out of 36.53
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
GFPP | Geranylfarnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
HPP | Hexaprenyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsR | Pleiotropic regulatory for antibiotic production

NZ_JACSPO010000001.1 - Region 1 - azole-containing-RiPP
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 345,433 - 368,784 nt. (total: 23,352 nt) Show pHMM detection rules used
azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Azole RiPPs
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: reductase
H9624_RS01665: alkyl hydroperoxide reductase subunit

smcogs
  SMCOG1176: alkyl hydroperoxide reductase subunit

Hydrolases: protease
H9624_RS01660: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | azole-containing-RiPP | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001170.5 |  | 0.40 | ribosomal | clostridiolysin S | Clostridium sporogenes ATCC 15579
BGC0000564.5 |  | 0.40 | ribosomal | clostridiolysin S | Clostridium botulinum A str. ATCC 3502
BGC0002036.4 |  | 0.36 | other (other) | dehydrofosmidomycin | Streptomyces lavendulae
BGC0000285.5 |  | 0.35 | PKS, saccharide | flaviolin, flaviolin rhamnoside, 3,3'-diflaviolin | Saccharopolyspora erythraea
BGC0001002.5 |  | 0.33 | NRPS, PKS | jawsamycin | Streptomyces roseoverticillatus
BGC0001637.3 |  | 0.31 | NRPS | kleboxymycin | Klebsiella oxytoca
BGC0001228.5 |  | 0.31 | NRPS | retimycin A | Salinispora arenicola CNT005
BGC0000415.5 |  | 0.31 | NRPS | quinomycin | Streptomyces griseovariabilis subsp. bandungensis
BGC0000448.5 |  | 0.30 | NRPS | tomaymycin | Streptomyces achromogenes
BGC0000339.5 |  | 0.30 | NRPS | echinomycin | Streptomyces lasaliensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001170.5 |  | 0.40 | ribosomal | clostridiolysin S | Clostridium sporogenes ATCC 15579
BGC0000564.5 |  | 0.40 | ribosomal | clostridiolysin S | Clostridium botulinum A str. ATCC 3502
BGC0002036.4 |  | 0.36 | other (other) | dehydrofosmidomycin | Streptomyces lavendulae
BGC0000285.5 |  | 0.35 | PKS, saccharide | flaviolin, flaviolin rhamnoside, 3,3'-diflaviolin | Saccharopolyspora erythraea
BGC0001002.5 |  | 0.33 | NRPS, PKS | jawsamycin | Streptomyces roseoverticillatus
BGC0001637.3 |  | 0.31 | NRPS | kleboxymycin | Klebsiella oxytoca
BGC0001228.5 |  | 0.31 | NRPS | retimycin A | Salinispora arenicola CNT005
BGC0000415.5 |  | 0.31 | NRPS | quinomycin | Streptomyces griseovariabilis subsp. bandungensis
BGC0000448.5 |  | 0.30 | NRPS | tomaymycin | Streptomyces achromogenes
BGC0000339.5 |  | 0.30 | NRPS | echinomycin | Streptomyces lasaliensis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.63 out of 18.46
Confidence: medium
Additional weak hits (4):
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.13 out of 25.75
Confidence: weak
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.17 out of 26.85
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.26 out of 30.22
Confidence: weak
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 19.54 out of 27.04
Confidence: weak
(Thi)azol(in)e containing peptide predictions
Lists the possible core peptides for each biosynthetic enzyme. Predicted tail sequences are also shown, if present.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.
No core peptides found.
TFBS Finder
Azole RiPPs
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
RpoN | Regulator of nitrogen assimilation and virulence

Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its possible molecular weights and the scores for cleavage site prediction and RODEO. If relevant, other features, such as macrocycle and amidation, will also be listed.
No core peptides found.
NZ_JACSPO010000001.1 - Region 2 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 500,141 - 521,220 nt. (total: 21,080 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
H9624_RS02360: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Ligases: synthetase
H9624_RS02395: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000677.5 |  | 0.42 | terpene | cyclooctatin | Streptomyces melanosporofaciens
BGC0002404.2 |  | 0.41 | other (other) | falcarindiol | Solanum lycopersicum
BGC0001910.4 |  | 0.39 | terpene | cyslabdan A, cyslabdan B, cyslabdan C | Streptomyces cyslabdanicus
BGC0001456.3 |  | 0.39 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000664.5 |  | 0.38 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001911.3 |  | 0.38 | terpene | raimonol | Streptomyces anulatus
BGC0001227.3 |  | 0.38 | terpene | isorenieratene | Streptomyces collinus Tu 365
BGC0000633.3 |  | 0.37 | terpene | carotenoid | Streptomyces avermitilis
BGC0002309.2 |  | 0.37 | terpene | cattleyene | Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0001521.3 |  | 0.37 | NRPS | auriculamide | Herpetosiphon aurantiacus DSM 785

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000677.5 |  | 0.42 | terpene | cyclooctatin | Streptomyces melanosporofaciens
BGC0002404.2 |  | 0.41 | other (other) | falcarindiol | Solanum lycopersicum
BGC0001910.4 |  | 0.39 | terpene | cyslabdan A, cyslabdan B, cyslabdan C | Streptomyces cyslabdanicus
BGC0001456.3 |  | 0.39 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000664.5 |  | 0.38 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001911.3 |  | 0.38 | terpene | raimonol | Streptomyces anulatus
BGC0001227.3 |  | 0.38 | terpene | isorenieratene | Streptomyces collinus Tu 365
BGC0000633.3 |  | 0.37 | terpene | carotenoid | Streptomyces avermitilis
BGC0002309.2 |  | 0.37 | terpene | cattleyene | Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0001521.3 |  | 0.37 | NRPS | auriculamide | Herpetosiphon aurantiacus DSM 785

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP
diterpene precursor |  | GGPP | C20 | acyclic | PP
sesterterpene precursor |  | GFPP | C25 | acyclic | PP
triterpene precursor |  | HPP | C30 | acyclic | PP

Genes with terpene domains:
H9624_RS02395: PT_FPPS_like
Domain 1 (45 - 357): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: unknown

Reactions:
  IPP, DMAPP → FPP
  IPP, DMAPP → GGPP
  IPP, DMAPP → GFPP
  IPP, DMAPP → HPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 16.26 out of 19.26
Confidence: medium
NrdR
Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 23.42 out of 27.18
Confidence: medium
Additional weak hits (7):
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 17.30 out of 21.84
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 13.87 out of 28.14
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 16.54 out of 30.97
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 14.10 out of 28.14
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 18.55 out of 30.97
Confidence: weak
NrdR
Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 20.12 out of 27.18
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 19.72 out of 28.19
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
GFPP | Geranylfarnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
HPP | Hexaprenyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
NrdR | Represses ribonucleotide reductase encoding genes

NZ_JACSPO010000001.1 - Region 3 - lanthipeptide-class-v
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 696,669 - 738,674 nt. (total: 42,006 nt) Show pHMM detection rules used
lanthipeptide-class-v: (APH and HopA1)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase
H9624_RS03240: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

H9624_RS03380: oxidoreductase

smcogs
  SMCOG1079: oxidoreductase

Hydrolases: hydrolase protease
H9624_RS03285: beta-lactamase

smcogs
  SMCOG1053: beta-lactamase

H9624_RS03310: beta-lactamase

smcogs
  SMCOG1053: beta-lactamase

H9624_RS03340: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase dehydratase
H9624_RS03325: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

H9624_RS03360: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

Translocases: transporter
H9624_RS03245: sugar-binding lipoprotein

smcogs
  SMCOG1143: sugar-binding lipoprotein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-v | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000622.5 |  | 0.50 | ribosomal | megacin | Bacillus megaterium
BGC0000503.5 |  | 0.48 | ribosomal | cinnamycin | Streptomyces cinnamoneus
BGC0002346.3 |  | 0.48 | ribosomal | kyamicin | Saccharopolyspora sp.
BGC0000551.5 |  | 0.46 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000528.5 |  | 0.46 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0002316.2 |  | 0.45 | ribosomal | cebulantin | Saccharopolyspora cebuensis
BGC0000518.3 |  | 0.43 | ribosomal | informatipeptin | Streptomyces viridochromogenes DSM 40736
BGC0001374.5 |  | 0.43 | other (other) | thienodolin | Streptomyces albogriseolus
BGC0002629.2 |  | 0.43 | ribosomal | limnothamide | Limnothrix sp. CACIAM 69d
BGC0000874.5 |  | 0.42 | other (other) | blasticidin S | Streptomyces griseochromogenes

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000622.5 |  | 0.50 | ribosomal | megacin | Bacillus megaterium
BGC0000503.5 |  | 0.48 | ribosomal | cinnamycin | Streptomyces cinnamoneus
BGC0002346.3 |  | 0.48 | ribosomal | kyamicin | Saccharopolyspora sp.
BGC0000551.5 |  | 0.46 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000528.5 |  | 0.46 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0002316.2 |  | 0.45 | ribosomal | cebulantin | Saccharopolyspora cebuensis
BGC0000518.3 |  | 0.43 | ribosomal | informatipeptin | Streptomyces viridochromogenes DSM 40736
BGC0001374.5 |  | 0.43 | other (other) | thienodolin | Streptomyces albogriseolus
BGC0002629.2 |  | 0.43 | ribosomal | limnothamide | Limnothrix sp. CACIAM 69d
BGC0000874.5 |  | 0.42 | other (other) | blasticidin S | Streptomyces griseochromogenes

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.
Lanthipeptides - No core peptides found.
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.73 out of 23.79
Confidence: medium
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 19.52 out of 19.52
Confidence: strong
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 18.42 out of 19.52
Confidence: strong
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 24.24 out of 29.65
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.98 out of 24.78
Confidence: medium
Additional weak hits (2):
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 17.45 out of 30.25
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 23.84 out of 30.22
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.
No core peptides found.
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsQ1 | Two-component system AfsQ1-Q2, activator of antibiotic production
IolR | Regulator of the inositol catabolism
LexA variant 1 | Repressor of DNA damage response
LexA variant 2 | Repressor of DNA damage response

NZ_JACSPO010000001.1 - Region 4 - lassopeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 977,407 - 1,002,117 nt. (total: 24,711 nt) Show pHMM detection rules used
lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lasso peptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: hydrolase
H9624_RS04520: alpha/beta hydrolase fold protein

smcogs
  SMCOG1036: alpha/beta hydrolase fold protein

H9624_RS04540: asparagine synthase (glutamine-hydrolyzing)

smcogs
  SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lassopeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000571.3 |  | 0.49 | ribosomal | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0002064.2 |  | 0.45 | ribosomal | felipeptin A2, felipeptin A1 | Amycolatopsis sp. YIM 10
BGC0002306.2 |  | 0.43 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0001229.4 |  | 0.42 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000517.4 |  | 0.41 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000504.5 |  | 0.41 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000538.3 |  | 0.40 | ribosomal | nisin Z | Lactococcus lactis
BGC0002144.3 |  | 0.40 | ribosomal | phazolicin | Rhizobium sp. Pop5
BGC0000619.3 |  | 0.40 | ribosomal | gassericin T | Lactobacillus gasseri
BGC0001388.3 |  | 0.40 | ribosomal | gassericin E | Lactobacillus gasseri

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000571.3 |  | 0.49 | ribosomal | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0002064.2 |  | 0.45 | ribosomal | felipeptin A2, felipeptin A1 | Amycolatopsis sp. YIM 10
BGC0002306.2 |  | 0.43 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0001229.4 |  | 0.42 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0000517.4 |  | 0.41 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000504.5 |  | 0.41 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000538.3 |  | 0.40 | ribosomal | nisin Z | Lactococcus lactis
BGC0002144.3 |  | 0.40 | ribosomal | phazolicin | Rhizobium sp. Pop5
BGC0000619.3 |  | 0.40 | ribosomal | gassericin T | Lactobacillus gasseri
BGC0001388.3 |  | 0.40 | ribosomal | gassericin E | Lactobacillus gasseri

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lasso peptide predictions
Lists the possible core peptides for each biosynthetic enzyme. Each core peptide shows the leader and core peptide sequences.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.
Lassopeptides - No core peptides found.
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.80 out of 23.79
Confidence: medium
Additional weak hits (4):
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 17.25 out of 24.78
Confidence: weak
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.86 out of 19.52
Confidence: weak
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.28 out of 19.26
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 18.44 out of 28.19
Confidence: weak
Lasso peptides
RREFinder
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of disulfide bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.
No core peptides found.
RRE predictions
RREfinder results sidepanel.

lassopeptide protocluster (977406...1002117)
H9624_RS04560
  RRE type: Stand_Alone_Lasso_RRE
  Location: 4 - 82
  Score: 62.8

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
IolR | Regulator of the inositol catabolism

NZ_JACSPO010000002.1 - Region 1 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 272,713 - 300,332 nt. (total: 27,620 nt) Show pHMM detection rules used
Region on contig edge.
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
H9624_RS07525: aldo/keto reductase family oxidoreductase

smcogs
  SMCOG1039: aldo/keto reductase family oxidoreductase

H9624_RS07555: oxidoreductase

smcogs
  SMCOG1161: oxidoreductase

Transferases: aminotransferase methyltransferase
H9624_RS07550: Methylation

MITE
  MITE0000155Methylation (identity: 70.30%)
smcogs
  SMCOG1150: isoprenylcysteine carboxyl methyltransferase

H9624_RS07570: aminotransferase class V

smcogs
  SMCOG1139: aminotransferase class V

Hydrolases: hydrolase
H9624_RS07490: HAD-superfamily hydrolase, subfamily IA, variant

smcogs
  SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

Ligases: synthase
H9624_RS07545: chalcone and stilbene synthase domain protein

smcogs
  SMCOG1024: chalcone and stilbene synthase domain protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000282.3 |  | 0.74 | PKS | 2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3 |  | 0.51 | PKS | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0001077.4 |  | 0.46 | PKS | 6-anteisoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-geranyl-2-methoxyhydroquinone, 6-palmityl-4-O-geranyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-palmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone | Actinoplanes missouriensis 431
BGC0002362.3 |  | 0.42 | PKS | loseolamycin A1, loseolamycin A2 | Micromonospora endolithica
BGC0002447.3 |  | 0.39 | ribosomal | cerecyclin | Bacillus cereus
BGC0001909.3 |  | 0.38 | PKS | strobilurin A | Strobilurus tenacellus
BGC0000487.5 |  | 0.38 | ribosomal | carnocyclin | Carnobacterium maltaromaticum
BGC0002567.2 |  | 0.38 | other (other) | EDHA | Streptomyces sp. MA5143a
BGC0001285.5 |  | 0.38 | other (fatty acid) | pseudopyronine A, pseudopyronine B | Pseudomonas putida
BGC0002666.2 |  | 0.38 | NRPS, other (other) | Legonmycin A, Legonmycin B, Legonindolizine A, Legonindolizine B | Streptomyces sp. MA37

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000282.3 |  | 0.74 | PKS | 2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3 |  | 0.51 | PKS | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0001077.4 |  | 0.46 | PKS | 6-anteisoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrogeranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-geranyl-2-methoxyhydroquinone, 6-palmityl-4-O-geranyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-geranyl-2-methoxyhydroquinone, 6-isopalmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-palmityl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-anteisoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone, 6-isoheptadecyl-4-O-dihydrofarnesyl-2-methoxyhydroquinone | Actinoplanes missouriensis 431
BGC0002362.3 |  | 0.42 | PKS | loseolamycin A1, loseolamycin A2 | Micromonospora endolithica
BGC0002447.3 |  | 0.39 | ribosomal | cerecyclin | Bacillus cereus
BGC0001909.3 |  | 0.38 | PKS | strobilurin A | Strobilurus tenacellus
BGC0000487.5 |  | 0.38 | ribosomal | carnocyclin | Carnobacterium maltaromaticum
BGC0002567.2 |  | 0.38 | other (other) | EDHA | Streptomyces sp. MA5143a
BGC0001285.5 |  | 0.38 | other (fatty acid) | pseudopyronine A, pseudopyronine B | Pseudomonas putida
BGC0002666.2 |  | 0.38 | NRPS, other (other) | Legonmycin A, Legonmycin B, Legonindolizine A, Legonindolizine B | Streptomyces sp. MA37

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05
Confidence: medium
Additional weak hits (1):
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.27 out of 20.01
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsR | Pleiotropic regulatory for antibiotic production

NZ_JACSPO010000004.1 - Region 1 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 18,535 - 42,695 nt. (total: 24,161 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
H9624_RS09070: dehydrogenase

smcogs
  SMCOG1222: dehydrogenase

Ligases: synthase synthetase
H9624_RS09060: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

H9624_RS09095: polyprenol-monophosphomannose synthase ppm1

smcogs
  SMCOG1123: polyprenol-monophosphomannose synthase ppm1

Translocases: transport
H9624_RS09045: MMPL domain-containing transport protein

smcogs
  SMCOG1035: MMPL domain-containing transport protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000644.3 |  | 0.71 | terpene | carotenoid | Dietzia sp. CQ4
BGC0000637.3 |  | 0.63 | terpene | carotenoid | Corynebacterium glutamicum
BGC0000650.3 |  | 0.59 | terpene | carotenoid | Algoriphagus sp. KK10202C
BGC0000648.3 |  | 0.55 | terpene | carotenoid | Myxococcus xanthus
BGC0000656.5 |  | 0.50 | terpene | zeaxanthin | Xanthobacter autotrophicus Py2
BGC0000636.3 |  | 0.50 | terpene | carotenoid | Brevibacterium linens
BGC0000664.5 |  | 0.48 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0002400.2 |  | 0.48 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0001456.3 |  | 0.48 | terpene | isorenieratene | Streptomyces argillaceus
BGC0001227.3 |  | 0.47 | terpene | isorenieratene | Streptomyces collinus Tu 365

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000644.3 |  | 0.71 | terpene | carotenoid | Dietzia sp. CQ4
BGC0000637.3 |  | 0.63 | terpene | carotenoid | Corynebacterium glutamicum
BGC0000650.3 |  | 0.59 | terpene | carotenoid | Algoriphagus sp. KK10202C
BGC0000648.3 |  | 0.55 | terpene | carotenoid | Myxococcus xanthus
BGC0000656.5 |  | 0.50 | terpene | zeaxanthin | Xanthobacter autotrophicus Py2
BGC0000636.3 |  | 0.50 | terpene | carotenoid | Brevibacterium linens
BGC0000664.5 |  | 0.48 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0002400.2 |  | 0.48 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0001456.3 |  | 0.48 | terpene | isorenieratene | Streptomyces argillaceus
BGC0001227.3 |  | 0.47 | terpene | isorenieratene | Streptomyces collinus Tu 365

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
tetraterpene | C40 carotenoid |  | C40 | unknown | unknown

Genes with terpene domains:
H9624_RS09060: PT_FPPS_like
Domain 1 (44 - 329): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: unknown

Reactions:
  IPP, DMAPP → FPP
  IPP, DMAPP → GGPP
  IPP, DMAPP → GFPP
  IPP, DMAPP → HPP

H9624_RS09065: PT_phytoene_like
Domain 1 (26 - 281): Prenyltransferase; Phytoene synthase like
Subtype: unknown

Reactions:
  FPP → diapophytoene
  FPP → PSPP
  FPP → squalene
  GGPP → phytoene
  PSPP → hydroxysqualene

H9624_RS09075: Lycopene_cycl
Domain 1 (4 - 92): Lycopene cyclase

Reactions:
  C40_carotenoid → C40_carotenoid

H9624_RS09080: Lycopene_cycl
Domain 1 (1 - 93): Lycopene cyclase

Reactions:
  C40_carotenoid → C40_carotenoid

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 30.47 out of 36.53
Confidence: medium
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 19.52 out of 19.52
Confidence: strong
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 18.42 out of 19.52
Confidence: strong
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.88 out of 20.47
Confidence: medium
Additional weak hits (5):
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.88 out of 25.75
Confidence: weak
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 13.03 out of 18.57
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 15.51 out of 21.55
Confidence: weak
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 17.34 out of 28.19
Confidence: weak
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 17.99 out of 25.31
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
GFPP | Geranylfarnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
HPP | Hexaprenyl diphosphate
IPP | Isopentenyl diphosphate
PSPP | Presqualene diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsQ1 | Two-component system AfsQ1-Q2, activator of antibiotic production
DmdR1 | Iron(II)-dependent repressor
VqsM | Regulator of quorum-sensing signalling systems

NZ_JACSPO010000008.1 - Region 1 - ectoine
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 38,434 - 48,823 nt. (total: 10,390 nt) Show pHMM detection rules used
ectoine: ectoine_synt

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: aminotransferase
H9624_RS12720: aminotransferase class-III

smcogs
  SMCOG1013: aminotransferase class-III

Hydrolases: deacetylase
H9624_RS12695: acetylornithine deacetylase

smcogs
  SMCOG1247: acetylornithine deacetylase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ectoine | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000855.3 |  | 0.72 | other (other) | ectoine | Methylomicrobium kenyense
BGC0000859.3 |  | 0.72 | other (other) | ectoine | Methylomicrobium alcaliphilum
BGC0000852.5 |  | 0.70 | other (other) | ectoine | Sporosarcina pasteurii
BGC0002052.3 |  | 0.70 | other (ectoine) | ectoine | Streptomyces sp.
BGC0000853.3 |  | 0.69 | other (other) | ectoine | Streptomyces anulatus
BGC0000858.3 |  | 0.66 | other (other) | ectoine | Methylobacter marinus
BGC0000857.3 |  | 0.64 | other (other) | ectoine | Methylophaga alcalica
BGC0000860.3 |  | 0.60 | other (other) | ectoine | Methylarcula marina
BGC0000854.3 |  | 0.58 | other (other) | ectoine | Methylomicrobium alcaliphilum 20Z
BGC0000856.3 |  | 0.55 | other (other) | ectoine | Methylophaga thalassica

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000855.3 |  | 0.72 | other (other) | ectoine | Methylomicrobium kenyense
BGC0000859.3 |  | 0.72 | other (other) | ectoine | Methylomicrobium alcaliphilum
BGC0000852.5 |  | 0.70 | other (other) | ectoine | Sporosarcina pasteurii
BGC0002052.3 |  | 0.70 | other (ectoine) | ectoine | Streptomyces sp.
BGC0000853.3 |  | 0.69 | other (other) | ectoine | Streptomyces anulatus
BGC0000858.3 |  | 0.66 | other (other) | ectoine | Methylobacter marinus
BGC0000857.3 |  | 0.64 | other (other) | ectoine | Methylophaga alcalica
BGC0000860.3 |  | 0.60 | other (other) | ectoine | Methylarcula marina
BGC0000854.3 |  | 0.58 | other (other) | ectoine | Methylomicrobium alcaliphilum 20Z
BGC0000856.3 |  | 0.55 | other (other) | ectoine | Methylophaga thalassica

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
No hits above weak threshold.
Weak hits (1):
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.19 out of 26.85
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
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