GCF_009811695.1 - 5 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_BLIS01000009.1 (Streptococcus canis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 9.1	terpene-precursor	43,028	63,900
Region 9.2	lanthipeptide-class-ii	133,530	161,332	Medium	lacticin 3147 A1/lacticin 3147 A2	ribosomal:RiPP:Lanthipeptide

NZ_BLIS01000011.1 (Streptococcus canis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 11.1	terpene-precursor	133,901	154,899

NZ_BLIS01000012.1 (Streptococcus canis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 12.1	T3PKS	1	29,969
Region 12.2	azole-containing-RiPP	136,448	160,210	High	streptolysin S	ribosomal:RiPP:LAP

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 9.1	terpene-precursor	43,028	63,900
Region 9.2	lanthipeptide-class-ii	133,530	161,332	Medium	lacticin 3147 A1/lacticin 3147 A2	ribosomal:RiPP:Lanthipeptide
Region 11.1	terpene-precursor	133,901	154,899
Region 12.1	T3PKS	1	29,969
Region 12.2	azole-containing-RiPP	136,448	160,210	High	streptolysin S	ribosomal:RiPP:LAP

No secondary metabolite regions were found in these records:: NZ_BLIS01000001.1 (Streptococcus canis); NZ_BLIS01000002.1 (Streptococcus canis); NZ_BLIS01000003.1 (Streptococcus canis); NZ_BLIS01000004.1 (Streptococcus canis); NZ_BLIS01000005.1 (Streptococcus canis); NZ_BLIS01000006.1 (Streptococcus canis); NZ_BLIS01000007.1 (Streptococcus canis); NZ_BLIS01000008.1 (Streptococcus canis); NZ_BLIS01000010.1 (Streptococcus canis); NZ_BLIS01000013.1 (Streptococcus canis); NZ_BLIS01000014.1 (Streptococcus canis); NZ_BLIS01000015.1 (Streptococcus canis); NZ_BLIS01000016.1 (Streptococcus canis); NZ_BLIS01000017.1 (Streptococcus canis); NZ_BLIS01000018.1 (Streptococcus canis); NZ_BLIS01000019.1 (Streptococcus canis); NZ_BLIS01000021.1 (Streptococcus canis); NZ_BLIS01000022.1 (Streptococcus canis); NZ_BLIS01000023.1 (Streptococcus canis); NZ_BLIS01000025.1 (Streptococcus canis); NZ_BLIS01000026.1 (Streptococcus canis); NZ_BLIS01000028.1 (Streptococcus canis); NZ_BLIS01000030.1 (Streptococcus canis); NZ_BLIS01000031.1 (Streptococcus canis); NZ_BLIS01000032.1 (Streptococcus canis); NZ_BLIS01000034.1 (Streptococcus canis); NZ_BLIS01000035.1 (Streptococcus canis); NZ_BLIS01000037.1 (Streptococcus canis)

Compact view

NZ_BLIS01000009.1 - Region 1 - terpene-precursor

Download region GenBank file

Download region SVG

Location: 43,028 - 63,900 nt. (total: 20,873 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: deaminase

GVO03_RS04370: ornithine cyclodeaminase

smcogs: SMCOG1158: ornithine cyclodeaminase

Ligases: synthetase

GVO03_RS04400: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0001605.3	0.32	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0000633.3	0.31	terpene	carotenoid	Streptomyces avermitilis
BGC0001227.3	0.31	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000648.3	0.31	terpene	carotenoid	Myxococcus xanthus
BGC0001456.3	0.30	terpene	isorenieratene	Streptomyces argillaceus
BGC0001529.5	0.30	other (other)	benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K	Streptomyces sp. RI18
BGC0001756.3	0.28	terpene	retigeranin, arathanatriene	Arabidopsis thaliana

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0001605.3	0.32	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0000633.3	0.31	terpene	carotenoid	Streptomyces avermitilis
BGC0001227.3	0.31	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000648.3	0.31	terpene	carotenoid	Myxococcus xanthus
BGC0001456.3	0.30	terpene	isorenieratene	Streptomyces argillaceus
BGC0001529.5	0.30	other (other)	benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K	Streptomyces sp. RI18
BGC0001756.3	0.28	terpene	retigeranin, arathanatriene	Arabidopsis thaliana

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

GVO03_RS04400: PT_FPPS_like

Domain 1 (25 - 282): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: IPP, DMAPP → FPP

Transcription Factor Binding Sites

Binding sites found:

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.00 out of 26.85

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.67 out of 25.31

Confidence: medium

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 26.23 out of 28.14

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.54 out of 28.19

Confidence: medium

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CatR	H2O2-responsive repressor
PerR	Peroxide regulator
RutR	Regulator of the pyrimidine and purine metabolism
ZuR variant 1	Zinc-responsive repressor

NZ_BLIS01000009.1 - Region 2 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 133,530 - 161,332 nt. (total: 27,803 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

GVO03_RS04845: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Hydrolases: peptidase

GVO03_RS04780: methionine aminopeptidase

smcogs: SMCOG1172: methionine aminopeptidase

Lyases: cyclase

GVO03_RS04830: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

GVO03_RS04840: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000520.5	0.77	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0000555.3	0.71	ribosomal	staphylococcin C55 α, staphylococcin C55 β	Staphylococcus aureus
BGC0002110.3	0.61	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000497.3	0.54	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0000623.3	0.54	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001229.4	0.53	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0001210.5	0.52	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0001391.3	0.51	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000517.4	0.51	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0000552.3	0.50	ribosomal	SmbA, SmbB	Streptococcus mutans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000520.5	0.77	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0000555.3	0.71	ribosomal	staphylococcin C55 α, staphylococcin C55 β	Staphylococcus aureus
BGC0002110.3	0.61	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000497.3	0.54	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0000623.3	0.54	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001229.4	0.53	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0001210.5	0.52	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0001391.3	0.51	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000517.4	0.51	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0000552.3	0.50	ribosomal	SmbA, SmbB	Streptococcus mutans

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for GVO03_RS04830

GVO03_RS04820

Leader:

MDKHSEVTLENEILFQEFDEDVFGA

Core:

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

Core with dehydrations:

CysDhbDhbNDhbFDhaLDhaDYWGNKGNWCysDhbLDhbHECysMNWCysK

antiSMASH-DB 4.0 matches for GVO03_RS04820

100.0%

NZ_BLIS01000009.1and 7 others:

NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04820_lanthipeptideNZ_LR134317.1 Lanthipeptides: EL136_RS01685_lanthipeptideNZ_LR134317.1 Lanthipeptides: EL136_RS01685_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02620_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02620_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01935_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01935_lanthipeptide

Lanthipeptides: GVO03_RS04820_lanthipeptide

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

93.3%

NZ_AP026714.1and 21 others:

NZ_AP026714.1 Lanthipeptides: PO853_RS06515_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11265_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11265_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03985_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03985_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09810_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09810_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00085_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00085_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07700_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07700_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03735_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03735_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00120_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00120_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07750_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07750_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04675_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04675_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07990_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07990_lanthipeptide

Lanthipeptides: PO853_RS06515_lanthipeptide

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

CTTNTFSLSDYWGNKGNWCT THECM WCK

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

90.0%

NZ_CP061868.1and 1 other:

NZ_CP061868.1 Lanthipeptides: IE339_RS06330_lanthipeptide

Lanthipeptides: IE339_RS06330_lanthipeptide

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

CTTNTFSLSDYWGNKG WCT THECM+WCK

CTTNTFSLSDYWGNKGGWCTATHECMSWCK

with 107 more sequence matches

Only the first 10 are displayed here.

90.0%

NZ_PCGR01000003.1and 1 other:

NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09620_lanthipeptide

Lanthipeptides: CQS04_RS09620_lanthipeptide

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

CTTNTFSLSDYWGN GNWCT THECM+WCK

CTTNTFSLSDYWGNNGNWCTATHECMSWCK

86.7%

NZ_CACZYW010000004.1and 1 other:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02825_lanthipeptide

Lanthipeptides: HUF10_RS02825_lanthipeptide

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

C+TNTFSLSDYWGN GNWCTL+HECM WCK

CSTNTFSLSDYWGNNGNWCTLSHECMAWCK

86.7%

NZ_CP027862.1and 1 other:

NZ_CP027862.1 Lanthipeptides: allorf_0097945_0098112_lanthipeptide

Lanthipeptides: allorf_0097945_0098112_lanthipeptide

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

C+TNTFSLSDYWGN+G WCTLTHECM+WCK

CSTNTFSLSDYWGNRGYWCTLTHECMSWCK

86.7%

NZ_QGEE01000020.1and 5 others:

NZ_QGEE01000020.1 Lanthipeptides: DKP74_RS06160_lanthipeptideNZ_QGEF01000018.1 Lanthipeptides: DKP75_RS05595_lanthipeptideNZ_QGEF01000018.1 Lanthipeptides: DKP75_RS05595_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05380_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05380_lanthipeptide

Lanthipeptides: DKP74_RS06160_lanthipeptide

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

C+TNTFSLSDYWGN+GNWCTL+HECM WCK

CSTNTFSLSDYWGNRGNWCTLSHECMAWCK

83.3%

NZ_CP034414.1and 1 other:

NZ_CP034414.1 Lanthipeptides: EI692_RS18440_lanthipeptide

Lanthipeptides: EI692_RS18440_lanthipeptide

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

C+TNTFSLSDYWGNKG WCT++HECM+WCK

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

83.3%

NZ_FMPI01000012.1and 1 other:

NZ_FMPI01000012.1 Lanthipeptides: BJR39_RS08305_lanthipeptide

Lanthipeptides: BJR39_RS08305_lanthipeptide

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

C+TNTFSLSDYWGN GNWCT +HECM+WCK

CSTNTFSLSDYWGNNGNWCTASHECMSWCK

83.3%

NZ_MIFN01000022.1and 1 other:

NZ_MIFN01000022.1 Lanthipeptides: BHL26_RS15350_lanthipeptide

Lanthipeptides: BHL26_RS15350_lanthipeptide

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

CTTNTFSLSDYWGN G+WC+L+HECM+WCK

CTTNTFSLSDYWGNDGSWCSLSHECMSWCK

83.3%

NZ_NUIO01000031.1and 1 other:

NZ_NUIO01000031.1 Lanthipeptides: CN977_RS23160_lanthipeptide

Lanthipeptides: CN977_RS23160_lanthipeptide

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

CTTNTFSLSDYWGN G+WCT THEC++WCK

CTTNTFSLSDYWGNDGSWCTATHECLSWCK

80.0%

NZ_CP016767.1and 11 others:

NZ_CP016767.1 Lanthipeptides: BCV50_RS13410_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15325_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15325_lanthipeptideNZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07920_lanthipeptideNZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07920_lanthipeptideNZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00580_lanthipeptideNZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00580_lanthipeptideNZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17015_lanthipeptideNZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17015_lanthipeptideNZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04645_lanthipeptideNZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04645_lanthipeptide

Lanthipeptides: BCV50_RS13410_lanthipeptide

CTTNTFSLSDYWGNKGNWCTLTHECMNWC

CTTNTFSLSDYWGNKG WCT++ ECM WC

CTTNTFSLSDYWGNKGGWCTVSKECMAWC

80.0%

NZ_CP051884.1and 2 others:

NZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptide

Lanthipeptides: HGK68_RS15125_lanthipeptide

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

C+TNTFSLSDYWGN G CT+THECM+WCK

CSTNTFSLSDYWGNNGWLCTITHECMSWCK

MIBiG 4.0 matches for GVO03_RS04820

66.7%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

CTTNTFSLSDYWGNKGNWCTLTHECMNWC

CTTNTFSLS+ GN G WCTLT EC C

CTTNTFSLSNALGNNGGWCTLTKECQPNC

43.3%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

FSLSDYWGNKGNWCTLTHECMNWC

+++S GNKG +CTLT ECM C

YNISCRLGNKGAYCTLTVECMPSC

15.4%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

CTLTHECMNWC

CTL+ EC C

CTLSKECQPNC

GVO03_RS04825

Leader:

MEQNNLELGKYLESDLLSLTDENVDGG

Core:

TTPASPATPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

Core with dehydrations:

DhbDhbPADhaPADhbPYDhbPAIGKGVIAVDhbAFVDhaANDhbCysPDhbDhaACysDhbRACys

antiSMASH-DB 4.0 matches for GVO03_RS04825

100.0%

NZ_BLIS01000009.1and 1 other:

NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04825_lanthipeptide

Lanthipeptides: GVO03_RS04825_lanthipeptide

TTPASPATPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

87.2%

NZ_QRWZ01000002.1and 3 others:

NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptide

Lanthipeptides: DWX18_RS02625_lanthipeptide

SPATPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

+PATPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

TPATPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

61.5%

NZ_LR134317.1and 1 other:

NZ_LR134317.1 Lanthipeptides: EL136_RS01690_lanthipeptide

Lanthipeptides: EL136_RS01690_lanthipeptide

ASPATPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

ASPATP+ + K +AVTAF+SANTCPT++CTRAC

ASPATPW---LVKASVAVTAFISANTCPTTSCTRAC

with 94 more sequence matches

Only the first 10 are displayed here.

59.0%

NZ_CACZYW010000004.1and 3 others:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide

Lanthipeptides: HUF10_RS02820_lanthipeptide

TTPASPATPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

TTPA+PATP ++AV+A+VS TCPT+ACTRAC

TTPATPATPV-------IVAVSAYVSDKTCPTTACTRAC

46.2%

NZ_CP033054.1and 11 others:

NZ_CP033054.1 Lanthipeptides: D9777_RS18840_lanthipeptideNZ_CP047268.1 Lanthipeptides: GKS41_RS18605_lanthipeptideNZ_CP047268.1 Lanthipeptides: GKS41_RS18605_lanthipeptideNZ_CP072563.1 Lanthipeptides: J6600_RS15935_lanthipeptideNZ_CP072563.1 Lanthipeptides: J6600_RS15935_lanthipeptideNZ_CP116014.1 Lanthipeptides: PF996_RS17885_lanthipeptideNZ_CP116014.1 Lanthipeptides: PF996_RS17885_lanthipeptideNZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12560_lanthipeptideNZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12560_lanthipeptideNZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01365_lanthipeptideNZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01365_lanthipeptide

Lanthipeptides: D9777_RS18840_lanthipeptide

ASPATP-YTPAIGKGVIAVTAFVSANTCPTSACTRAC

A+PAT T IG T +SA +CPTSACT+ C

ATPATVVLTATIGLTGTTFTVTLSAASCPTSACTKQC

46.2%

NZ_CP034414.1and 1 other:

NZ_CP034414.1 Lanthipeptides: EI692_RS18435_lanthipeptide

Lanthipeptides: EI692_RS18435_lanthipeptide

TPAIGKGVIAVTAFVSANTCPTSACTRAC

TPAI I V+ F+S NTCP++ACTRAC

TPAIS---ILVSGFISTNTCPSTACTRAC

46.2%

NZ_JALAPU010000003.1and 7 others:

NZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07925_lanthipeptideNZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00585_lanthipeptideNZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00585_lanthipeptideNZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17010_lanthipeptideNZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17010_lanthipeptideNZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04640_lanthipeptideNZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04640_lanthipeptide

Lanthipeptides: MOD17_RS07925_lanthipeptide

YTPAIGKGVIAVTAFVSANTCPTSACTRAC

+TPA+ VTA++S+NTCPT+ACTRAC

WTPALS----VVTAYISSNTCPTTACTRAC

46.2%

NZ_QGEE01000020.1and 3 others:

NZ_QGEE01000020.1 Lanthipeptides: DKP74_RS06165_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05385_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05385_lanthipeptide

Lanthipeptides: DKP74_RS06165_lanthipeptide

TPAIGKGVIAVTAFVSANTCPTSACTRAC

TP IG + V+ FVS++TCPT+ACTRAC

TPVIGYSAVIVSGFVSSHTCPTTACTRAC

41.0%

NZ_CM000721.1and 9 others:

NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide

Lanthipeptides: BCERE0010_RS29355_lanthipeptide

TPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

TP TP I IAVTA + CPT+ CT C

TPATPTIIGATIAVTASL----CPTTKCTSRC

41.0%

NZ_CP016767.1and 3 others:

NZ_CP016767.1 Lanthipeptides: BCV50_RS13415_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptide

Lanthipeptides: BCV50_RS13415_lanthipeptide

YTPAIGKGVIAVTAFVSANTCPTSACTRAC

+TPA+ +T ++S+NTCPT+ACTRAC

WTPALS----VITGYISSNTCPTTACTRAC

41.0%

NZ_CP017953.1and 15 others:

NZ_CP017953.1 Lanthipeptides: BAMY_RS16390_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06470_lanthipeptideNZ_CP021011.1 Lanthipeptides: B6257_RS06470_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15890_lanthipeptideNZ_CP041784.1 Lanthipeptides: FOV14_RS15890_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05695_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS05695_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16180_lanthipeptideNZ_CP097326.1 Lanthipeptides: M5J22_RS16180_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16150_lanthipeptideNZ_CP097784.1 Lanthipeptides: MF619_RS16150_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11805_lanthipeptideNZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11805_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06815_lanthipeptideNZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06815_lanthipeptide

Lanthipeptides: BAMY_RS16390_lanthipeptide

ASPATPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

A+P T IG T +SA +CPTSACT+ C

ATPTVVLTATIGLTGTTFTVTLSAASCPTSACTKQC

41.0%

NZ_CP086141.1and 1 other:

NZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptide

Lanthipeptides: LL065_RS24780_lanthipeptide

TPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

TP AI V + TA VSA TSACT++C

TPVVSAISATVASATA-VSALFTVTSACTKSC

41.0%

NZ_KE384533.1and 2 others:

NZ_KE384533.1 Lanthipeptides: K329_RS31315_lanthipeptideNZ_KE384533.1 Lanthipeptides: K329_RS31315_lanthipeptide

Lanthipeptides: K329_RS31315_lanthipeptide

TPAIGKGVIAVTAFVSANTCPTSACTRAC

TP I V V+A+VS NTCPT++CT C

TPTIVISV--VSAYVSTNTCPTTSCTDEC

MIBiG 4.0 matches for GVO03_RS04825

30.8%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

GVIAVTAFV----SANTCPTSACTRAC

G++A+ A V SA CPT+ CT C

GIVAIQAGVAVGVSAAFCPTTKCTSRC

17.9%

BGC0000582.4 (ADR72962.1):

Linaridin: cypemycin

ATPYTPAIGKGVI

ATP TP + + VI

ATPATPTVAQFVI

15.4%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

CPTSACTRAC

CPT+ CT C

CPTTKCTSKC

with 2 more sequence matches

12.8%

BGC0000582.4 (ADR72962.1):

Linaridin: cypemycin

ASPATP

A+PATP

ATPATP

10.3%

BGC0000582.4 (ADR72962.1):

Linaridin: cypemycin

TPASP

TPA+P

TPATP

GVO03_RS04860

Leader:

MKFSYNKLWKLLIDKGWTKSELRQKAGI

Core:

SSSTIAKLGKGENVTTDILLKICIALDCKIEDIIEIVNSK

Core with dehydrations:

DhaDhaDhaDhbIAKLGKGENVDhbDhbDILLKICysIALDCysKIEDIIEIVNDhaK

antiSMASH-DB 4.0 matches for GVO03_RS04860

100.0%

NZ_BLIS01000009.1and 5 others:

NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04860_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02665_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02665_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01890_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01890_lanthipeptide

Lanthipeptides: GVO03_RS04860_lanthipeptide

SSSTIAKLGKGENVTTDILLKICIALDCKIEDIIEIVNSK

80.0%

NZ_CP102135.1:

Lanthipeptides: NQZ98_RS01525_lanthipeptide

SSSTIAKLGKGENVTTDILLKICIALDCKIEDIIEIV

SSSTIAKLGKGENVTTD+LL+ICIALDC IEDI+EI+

SSSTIAKLGKGENVTTDVLLRICIALDCDIEDIVEII

32.5%

NZ_QUCI01000001.1:

Lanthipeptides: DW648_RS00980_lanthipeptide

SSSTIAKLGKGE-NVTTDILLKICIALDCKIEDIIEI

S +T++ + G+ N T + L +CIALD K E++

SRNTVSSIETGQFNPTAKLALVLCIALDKKFEELFYF

with 4 more sequence matches

17.5%

NZ_BBZK01000004.1:

Lanthipeptides: BGP73_RS05180_lanthipeptide

LLKICIALDCKIEDII

L IC LDC+ D++

LSAICRELDCQPGDLL

17.5%

NZ_CP047936.1:

Lanthipeptides: allorf_0851453_0851611_lanthipeptide

ALDCKIEDIIEIV

AL C + D+IEI+

ALRCFVHDVIEIL

17.4%

NC_009621.1and 4 others:

NZ_CP088111.1 Lanthipeptides: allorf_0786726_0786959_lanthipeptideNZ_NBUK01000063.1 Lanthipeptides: allorf_6661_6894_lanthipeptideNZ_VISX01000063.1 Lanthipeptides: allorf_1862_2095_lanthipeptideNZ_VITA01000039.1 Lanthipeptides: allorf_06616_06849_lanthipeptide

Lanthipeptides: allorf_1020482_1020715_lanthipeptide

KGENVTTDILLKICIALDC

+GEN+ T L+K + L C

QGENMVTKSLIKRLMMLVC

12.2%

NZ_SBIS02000007.1:

Lanthipeptides: EPL00_RS13710_lanthipeptide

NVTTDILLKICIALDCKIEDIIE

+ + ++ K+ DC+IED+ +

DPSIELAFKLADHFDCRIEDLFD

MIBiG 4.0 matches for GVO03_RS04860

10.0%

BGC0000563.4 (AEA03263.1):

Lanthipeptide: venezuelin

ILLKICIALDCK

+L +CI + C

LLNTVCIGISCA

GVO03_RS04870

Leader:

MQLPNKLYSYQKSTLAYLPRVLNEIKSGNSNVKDIFHA

Core:

ISEELDDPTDFLSIMDCLYALNAIEMSNEGEVKLCL

Core with dehydrations:

IDhaEELDDPDhbDFLDhaIMDCysLYALNAIEMDhaNEGEVKLCysL

antiSMASH-DB 4.0 matches for GVO03_RS04870

100.0%

NZ_BLIS01000009.1and 6 others:

NZ_CAAHHE010000002.1 Lanthipeptides: E9499_RS03005_lanthipeptideNZ_CAAHHN010000003.1 Lanthipeptides: E9502_RS05635_lanthipeptideNZ_CAAHRY010000002.1 Lanthipeptides: E9986_RS03100_lanthipeptideNZ_CAAIES010000002.1 Lanthipeptides: FAH15_RS02400_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02675_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01880_lanthipeptide

Lanthipeptides: GVO03_RS04870_lanthipeptide

ISEELDDPTDFLSIMDCLYALNAIEMSNEGEVKLCL

97.2%

NZ_CP102135.1:

Lanthipeptides: NQZ98_RS01535_lanthipeptide

ISEELDDPTDFLSIMDCLYALNAIEMSNEGEVKLCL

ISEELDDPTDFLSIMDCLYALNAIEMSNEGEV LCL

ISEELDDPTDFLSIMDCLYALNAIEMSNEGEVNLCL

19.4%

NZ_CAKMMP010000011.1:

Lanthipeptides: allorf_219369_219518_lanthipeptide

ISEELDDPTDFLSIMDC

I E+L + T ++S+M+C

IREDLCEQTWWVSLMNC

Lanthipeptide(s) for GVO03_RS04840

GVO03_RS04820

Leader:

MDKHSEVTLENEILFQEFDEDVFGA

Core:

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

Core with dehydrations:

CysDhbDhbNDhbFDhaLDhaDYWGNKGNWCysDhbLDhbHECysMNWCysK

antiSMASH-DB 4.0 matches for GVO03_RS04820

100.0%

NZ_BLIS01000009.1and 7 others:

Lanthipeptides: GVO03_RS04820_lanthipeptide

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

93.3%

NZ_AP026714.1and 21 others:

Lanthipeptides: PO853_RS06515_lanthipeptide

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

CTTNTFSLSDYWGNKGNWCT THECM WCK

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

90.0%

NZ_CP061868.1and 1 other:

NZ_CP061868.1 Lanthipeptides: IE339_RS06330_lanthipeptide

Lanthipeptides: IE339_RS06330_lanthipeptide

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

CTTNTFSLSDYWGNKG WCT THECM+WCK

CTTNTFSLSDYWGNKGGWCTATHECMSWCK

with 107 more sequence matches

Only the first 10 are displayed here.

90.0%

NZ_PCGR01000003.1and 1 other:

NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09620_lanthipeptide

Lanthipeptides: CQS04_RS09620_lanthipeptide

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

CTTNTFSLSDYWGN GNWCT THECM+WCK

CTTNTFSLSDYWGNNGNWCTATHECMSWCK

86.7%

NZ_CACZYW010000004.1and 1 other:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02825_lanthipeptide

Lanthipeptides: HUF10_RS02825_lanthipeptide

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

C+TNTFSLSDYWGN GNWCTL+HECM WCK

CSTNTFSLSDYWGNNGNWCTLSHECMAWCK

86.7%

NZ_CP027862.1and 1 other:

NZ_CP027862.1 Lanthipeptides: allorf_0097945_0098112_lanthipeptide

Lanthipeptides: allorf_0097945_0098112_lanthipeptide

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

C+TNTFSLSDYWGN+G WCTLTHECM+WCK

CSTNTFSLSDYWGNRGYWCTLTHECMSWCK

86.7%

NZ_QGEE01000020.1and 5 others:

Lanthipeptides: DKP74_RS06160_lanthipeptide

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

C+TNTFSLSDYWGN+GNWCTL+HECM WCK

CSTNTFSLSDYWGNRGNWCTLSHECMAWCK

83.3%

NZ_CP034414.1and 1 other:

NZ_CP034414.1 Lanthipeptides: EI692_RS18440_lanthipeptide

Lanthipeptides: EI692_RS18440_lanthipeptide

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

C+TNTFSLSDYWGNKG WCT++HECM+WCK

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

83.3%

NZ_FMPI01000012.1and 1 other:

NZ_FMPI01000012.1 Lanthipeptides: BJR39_RS08305_lanthipeptide

Lanthipeptides: BJR39_RS08305_lanthipeptide

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

C+TNTFSLSDYWGN GNWCT +HECM+WCK

CSTNTFSLSDYWGNNGNWCTASHECMSWCK

83.3%

NZ_MIFN01000022.1and 1 other:

NZ_MIFN01000022.1 Lanthipeptides: BHL26_RS15350_lanthipeptide

Lanthipeptides: BHL26_RS15350_lanthipeptide

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

CTTNTFSLSDYWGN G+WC+L+HECM+WCK

CTTNTFSLSDYWGNDGSWCSLSHECMSWCK

83.3%

NZ_NUIO01000031.1and 1 other:

NZ_NUIO01000031.1 Lanthipeptides: CN977_RS23160_lanthipeptide

Lanthipeptides: CN977_RS23160_lanthipeptide

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

CTTNTFSLSDYWGN G+WCT THEC++WCK

CTTNTFSLSDYWGNDGSWCTATHECLSWCK

80.0%

NZ_CP016767.1and 11 others:

Lanthipeptides: BCV50_RS13410_lanthipeptide

CTTNTFSLSDYWGNKGNWCTLTHECMNWC

CTTNTFSLSDYWGNKG WCT++ ECM WC

CTTNTFSLSDYWGNKGGWCTVSKECMAWC

80.0%

NZ_CP051884.1and 2 others:

NZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptide

Lanthipeptides: HGK68_RS15125_lanthipeptide

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

C+TNTFSLSDYWGN G CT+THECM+WCK

CSTNTFSLSDYWGNNGWLCTITHECMSWCK

MIBiG 4.0 matches for GVO03_RS04820

66.7%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

CTTNTFSLSDYWGNKGNWCTLTHECMNWC

CTTNTFSLS+ GN G WCTLT EC C

CTTNTFSLSNALGNNGGWCTLTKECQPNC

43.3%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

FSLSDYWGNKGNWCTLTHECMNWC

+++S GNKG +CTLT ECM C

YNISCRLGNKGAYCTLTVECMPSC

15.4%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

CTLTHECMNWC

CTL+ EC C

CTLSKECQPNC

GVO03_RS04825

Leader:

MEQNNLELGKYLESDLLSLTDENVDGG

Core:

TTPASPATPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

Core with dehydrations:

DhbDhbPADhaPADhbPYDhbPAIGKGVIAVDhbAFVDhaANDhbCysPDhbDhaACysDhbRACys

antiSMASH-DB 4.0 matches for GVO03_RS04825

100.0%

NZ_BLIS01000009.1and 1 other:

NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04825_lanthipeptide

Lanthipeptides: GVO03_RS04825_lanthipeptide

TTPASPATPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

87.2%

NZ_QRWZ01000002.1and 3 others:

NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptide

Lanthipeptides: DWX18_RS02625_lanthipeptide

SPATPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

+PATPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

TPATPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

61.5%

NZ_LR134317.1and 1 other:

NZ_LR134317.1 Lanthipeptides: EL136_RS01690_lanthipeptide

Lanthipeptides: EL136_RS01690_lanthipeptide

ASPATPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

ASPATP+ + K +AVTAF+SANTCPT++CTRAC

ASPATPW---LVKASVAVTAFISANTCPTTSCTRAC

with 94 more sequence matches

Only the first 10 are displayed here.

59.0%

NZ_CACZYW010000004.1and 3 others:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide

Lanthipeptides: HUF10_RS02820_lanthipeptide

TTPASPATPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

TTPA+PATP ++AV+A+VS TCPT+ACTRAC

TTPATPATPV-------IVAVSAYVSDKTCPTTACTRAC

46.2%

NZ_CP033054.1and 11 others:

Lanthipeptides: D9777_RS18840_lanthipeptide

ASPATP-YTPAIGKGVIAVTAFVSANTCPTSACTRAC

A+PAT T IG T +SA +CPTSACT+ C

ATPATVVLTATIGLTGTTFTVTLSAASCPTSACTKQC

46.2%

NZ_CP034414.1and 1 other:

NZ_CP034414.1 Lanthipeptides: EI692_RS18435_lanthipeptide

Lanthipeptides: EI692_RS18435_lanthipeptide

TPAIGKGVIAVTAFVSANTCPTSACTRAC

TPAI I V+ F+S NTCP++ACTRAC

TPAIS---ILVSGFISTNTCPSTACTRAC

46.2%

NZ_JALAPU010000003.1and 7 others:

Lanthipeptides: MOD17_RS07925_lanthipeptide

YTPAIGKGVIAVTAFVSANTCPTSACTRAC

+TPA+ VTA++S+NTCPT+ACTRAC

WTPALS----VVTAYISSNTCPTTACTRAC

46.2%

NZ_QGEE01000020.1and 3 others:

NZ_QGEE01000020.1 Lanthipeptides: DKP74_RS06165_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05385_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05385_lanthipeptide

Lanthipeptides: DKP74_RS06165_lanthipeptide

TPAIGKGVIAVTAFVSANTCPTSACTRAC

TP IG + V+ FVS++TCPT+ACTRAC

TPVIGYSAVIVSGFVSSHTCPTTACTRAC

41.0%

NZ_CM000721.1and 9 others:

Lanthipeptides: BCERE0010_RS29355_lanthipeptide

TPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

TP TP I IAVTA + CPT+ CT C

TPATPTIIGATIAVTASL----CPTTKCTSRC

41.0%

NZ_CP016767.1and 3 others:

NZ_CP016767.1 Lanthipeptides: BCV50_RS13415_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptide

Lanthipeptides: BCV50_RS13415_lanthipeptide

YTPAIGKGVIAVTAFVSANTCPTSACTRAC

+TPA+ +T ++S+NTCPT+ACTRAC

WTPALS----VITGYISSNTCPTTACTRAC

41.0%

NZ_CP017953.1and 15 others:

Lanthipeptides: BAMY_RS16390_lanthipeptide

ASPATPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

A+P T IG T +SA +CPTSACT+ C

ATPTVVLTATIGLTGTTFTVTLSAASCPTSACTKQC

41.0%

NZ_CP086141.1and 1 other:

NZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptide

Lanthipeptides: LL065_RS24780_lanthipeptide

TPYTPAIGKGVIAVTAFVSANTCPTSACTRAC

TP AI V + TA VSA TSACT++C

TPVVSAISATVASATA-VSALFTVTSACTKSC

41.0%

NZ_KE384533.1and 2 others:

NZ_KE384533.1 Lanthipeptides: K329_RS31315_lanthipeptideNZ_KE384533.1 Lanthipeptides: K329_RS31315_lanthipeptide

Lanthipeptides: K329_RS31315_lanthipeptide

TPAIGKGVIAVTAFVSANTCPTSACTRAC

TP I V V+A+VS NTCPT++CT C

TPTIVISV--VSAYVSTNTCPTTSCTDEC

MIBiG 4.0 matches for GVO03_RS04825

30.8%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

GVIAVTAFV----SANTCPTSACTRAC

G++A+ A V SA CPT+ CT C

GIVAIQAGVAVGVSAAFCPTTKCTSRC

17.9%

BGC0000582.4 (ADR72962.1):

Linaridin: cypemycin

ATPYTPAIGKGVI

ATP TP + + VI

ATPATPTVAQFVI

15.4%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

CPTSACTRAC

CPT+ CT C

CPTTKCTSKC

with 2 more sequence matches

12.8%

BGC0000582.4 (ADR72962.1):

Linaridin: cypemycin

ASPATP

A+PATP

ATPATP

10.3%

BGC0000582.4 (ADR72962.1):

Linaridin: cypemycin

TPASP

TPA+P

TPATP

GVO03_RS04860

Leader:

MKFSYNKLWKLLIDKGWTKSELRQKAGI

Core:

SSSTIAKLGKGENVTTDILLKICIALDCKIEDIIEIVNSK

Core with dehydrations:

DhaDhaDhaDhbIAKLGKGENVDhbDhbDILLKICysIALDCysKIEDIIEIVNDhaK

antiSMASH-DB 4.0 matches for GVO03_RS04860

100.0%

NZ_BLIS01000009.1and 5 others:

Lanthipeptides: GVO03_RS04860_lanthipeptide

SSSTIAKLGKGENVTTDILLKICIALDCKIEDIIEIVNSK

80.0%

NZ_CP102135.1:

Lanthipeptides: NQZ98_RS01525_lanthipeptide

SSSTIAKLGKGENVTTDILLKICIALDCKIEDIIEIV

SSSTIAKLGKGENVTTD+LL+ICIALDC IEDI+EI+

SSSTIAKLGKGENVTTDVLLRICIALDCDIEDIVEII

32.5%

NZ_QUCI01000001.1:

Lanthipeptides: DW648_RS00980_lanthipeptide

SSSTIAKLGKGE-NVTTDILLKICIALDCKIEDIIEI

S +T++ + G+ N T + L +CIALD K E++

SRNTVSSIETGQFNPTAKLALVLCIALDKKFEELFYF

with 4 more sequence matches

17.5%

NZ_BBZK01000004.1:

Lanthipeptides: BGP73_RS05180_lanthipeptide

LLKICIALDCKIEDII

L IC LDC+ D++

LSAICRELDCQPGDLL

17.5%

NZ_CP047936.1:

Lanthipeptides: allorf_0851453_0851611_lanthipeptide

ALDCKIEDIIEIV

AL C + D+IEI+

ALRCFVHDVIEIL

17.4%

NC_009621.1and 4 others:

Lanthipeptides: allorf_1020482_1020715_lanthipeptide

KGENVTTDILLKICIALDC

+GEN+ T L+K + L C

QGENMVTKSLIKRLMMLVC

12.2%

NZ_SBIS02000007.1:

Lanthipeptides: EPL00_RS13710_lanthipeptide

NVTTDILLKICIALDCKIEDIIE

+ + ++ K+ DC+IED+ +

DPSIELAFKLADHFDCRIEDLFD

MIBiG 4.0 matches for GVO03_RS04860

10.0%

BGC0000563.4 (AEA03263.1):

Lanthipeptide: venezuelin

ILLKICIALDCK

+L +CI + C

LLNTVCIGISCA

GVO03_RS04870

Leader:

MQLPNKLYSYQKSTLAYLPRVLNEIKSGNSNVKDIFHA

Core:

ISEELDDPTDFLSIMDCLYALNAIEMSNEGEVKLCL

Core with dehydrations:

IDhaEELDDPDhbDFLDhaIMDCysLYALNAIEMDhaNEGEVKLCysL

antiSMASH-DB 4.0 matches for GVO03_RS04870

100.0%

NZ_BLIS01000009.1and 6 others:

Lanthipeptides: GVO03_RS04870_lanthipeptide

ISEELDDPTDFLSIMDCLYALNAIEMSNEGEVKLCL

97.2%

NZ_CP102135.1:

Lanthipeptides: NQZ98_RS01535_lanthipeptide

ISEELDDPTDFLSIMDCLYALNAIEMSNEGEVKLCL

ISEELDDPTDFLSIMDCLYALNAIEMSNEGEV LCL

ISEELDDPTDFLSIMDCLYALNAIEMSNEGEVNLCL

19.4%

NZ_CAKMMP010000011.1:

Lanthipeptides: allorf_219369_219518_lanthipeptide

ISEELDDPTDFLSIMDC

I E+L + T ++S+M+C

IREDLCEQTWWVSLMNC

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.75 out of 29.38

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.95 out of 27.78

Confidence: strong

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.71 out of 28.19

Confidence: strong

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.18 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.47 out of 28.19

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.05 out of 18.16

Confidence: strong

Additional weak hits (4):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.91 out of 29.38

Confidence: weak

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 20.43 out of 32.38

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.54 out of 29.25

Confidence: weak

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.51 out of 23.43

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

GVO03_RS04820 - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 3416.5 Da

Molecular weight: 3418.8 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3436.8 Da N = 1; 3454.8 Da N = 2; 3472.9 Da N = 3

GVO03_RS04825 - Class II

Cleavage pHMM score: -2.60

RODEO score: 0

Monoisotopic mass: 3597.9 Da

Molecular weight: 3600.1 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3618.1 Da N = 1; 3636.1 Da N = 2; 3654.2 Da N = 3; 3672.2 Da N = 4; 3690.2 Da N = 5; 3708.2 Da N = 6; 3726.2 Da N = 7; 3744.3 Da N = 8

GVO03_RS04860 - Class II

Cleavage pHMM score: -6.60

RODEO score: 0

Monoisotopic mass: 4161.3 Da

Molecular weight: 4163.9 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 4181.9 Da N = 1; 4199.9 Da N = 2; 4217.9 Da N = 3; 4235.9 Da N = 4; 4254.0 Da N = 5

GVO03_RS04870 - Class II

Cleavage pHMM score: -7.00

RODEO score: 0

Monoisotopic mass: 3960.9 Da

Molecular weight: 3963.5 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3981.5 Da N = 1; 3999.5 Da N = 2

GVO03_RS04820 - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 3416.5 Da

Molecular weight: 3418.8 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3436.8 Da N = 1; 3454.8 Da N = 2; 3472.9 Da N = 3

GVO03_RS04825 - Class II

Cleavage pHMM score: -2.60

RODEO score: 0

Monoisotopic mass: 3597.9 Da

Molecular weight: 3600.1 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3618.1 Da N = 1; 3636.1 Da N = 2; 3654.2 Da N = 3; 3672.2 Da N = 4; 3690.2 Da N = 5; 3708.2 Da N = 6; 3726.2 Da N = 7; 3744.3 Da N = 8

GVO03_RS04860 - Class II

Cleavage pHMM score: -6.60

RODEO score: 0

Monoisotopic mass: 4161.3 Da

Molecular weight: 4163.9 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 4181.9 Da N = 1; 4199.9 Da N = 2; 4217.9 Da N = 3; 4235.9 Da N = 4; 4254.0 Da N = 5

GVO03_RS04870 - Class II

Cleavage pHMM score: -7.00

RODEO score: 0

Monoisotopic mass: 3960.9 Da

Molecular weight: 3963.5 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3981.5 Da N = 1; 3999.5 Da N = 2

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1	Ferric Uptake Regulator
ZuR variant 1	Zinc-responsive repressor

NZ_BLIS01000011.1 - Region 1 - terpene-precursor

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Location: 133,901 - 154,899 nt. (total: 20,999 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: synthetase

GVO03_RS06270: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000623.3	0.43	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000547.5	0.39	ribosomal	salivaricin 9	Streptococcus salivarius
BGC0002116.3	0.38	ribosomal	darobactin A	Photorhabdus khanii HGB 1456
BGC0001789.3	0.37	ribosomal	suicin 90-1330	Streptococcus suis
BGC0000536.3	0.37	ribosomal	nisin Q	Lactococcus lactis
BGC0000537.3	0.37	ribosomal	nisin U	Streptococcus uberis
BGC0000556.5	0.37	ribosomal	streptin	Streptococcus pyogenes
BGC0000515.4	0.37	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0000535.4	0.37	ribosomal	nisin A	Lactococcus lactis subsp. lactis
BGC0000506.4	0.37	ribosomal	entianin	Bacillus subtilis subsp. spizizenii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000623.3	0.43	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000547.5	0.39	ribosomal	salivaricin 9	Streptococcus salivarius
BGC0002116.3	0.38	ribosomal	darobactin A	Photorhabdus khanii HGB 1456
BGC0001789.3	0.37	ribosomal	suicin 90-1330	Streptococcus suis
BGC0000536.3	0.37	ribosomal	nisin Q	Lactococcus lactis
BGC0000537.3	0.37	ribosomal	nisin U	Streptococcus uberis
BGC0000556.5	0.37	ribosomal	streptin	Streptococcus pyogenes
BGC0000515.4	0.37	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0000535.4	0.37	ribosomal	nisin A	Lactococcus lactis subsp. lactis
BGC0000506.4	0.37	ribosomal	entianin	Bacillus subtilis subsp. spizizenii

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

GVO03_RS06270: PT_FPPS_like

Domain 1 (39 - 315): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.95 out of 27.78

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.06 out of 20.97

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.87 out of 26.06

Confidence: medium

Additional weak hits (4):

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.70 out of 27.55

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.48 out of 28.14

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.99 out of 30.22

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 24.96 out of 36.53

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MogR	Repressor of flagellar motility genes

NZ_BLIS01000012.1 - Region 1 - T3PKS

Download region GenBank file

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Location: 1 - 29,969 nt. (total: 29,969 nt) Show pHMM detection rules used

Region on contig edge.

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: reductase

GVO03_RS06885: hydroxymethylglutaryl-CoA reductase

smcogs: SMCOG1187: hydroxymethylglutaryl-CoA reductase

Hydrolases: deformylase esterase

GVO03_RS06925: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase

smcogs: SMCOG1283: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase

GVO03_RS06930: peptide deformylase

smcogs: SMCOG1275: peptide deformylase

Ligases: synthase

GVO03_RS06880: hydroxymethylglutaryl-CoA synthase

smcogs: SMCOG1043: hydroxymethylglutaryl-CoA synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000501.3	0.48	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0002561.3	0.44	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0000851.5	0.43	other (other)	albonoursin	Streptomyces noursei ATCC 11455
BGC0002306.2	0.43	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000551.5	0.42	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000513.3	0.41	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000563.4	0.41	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0002699.2	0.41	ribosomal	nostolysamide A, nostolysamide B	Nostoc punctiforme PCC 73102
BGC0000519.4	0.41	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000286.3	0.40	PKS	viguiepinol	Streptomyces sp. KO-3988

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000501.3	0.48	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0002561.3	0.44	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0000851.5	0.43	other (other)	albonoursin	Streptomyces noursei ATCC 11455
BGC0002306.2	0.43	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000551.5	0.42	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000513.3	0.41	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000563.4	0.41	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0002699.2	0.41	ribosomal	nostolysamide A, nostolysamide B	Nostoc punctiforme PCC 73102
BGC0000519.4	0.41	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000286.3	0.40	PKS	viguiepinol	Streptomyces sp. KO-3988

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.49 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.77 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.33 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.11 out of 26.06

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.40 out of 20.97

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.00 out of 27.78

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.63 out of 28.19

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 15.96 out of 18.16

Confidence: strong

Additional weak hits (3):

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 24.12 out of 36.53

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.33 out of 29.25

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.96 out of 29.25

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MogR	Repressor of flagellar motility genes
ZuR variant 1	Zinc-responsive repressor

NZ_BLIS01000012.1 - Region 2 - azole-containing-RiPP

Download region GenBank file

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Location: 136,448 - 160,210 nt. (total: 23,763 nt) Show pHMM detection rules used

azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Azole RiPPs

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: hydrolase

GVO03_RS07550: HAD-superfamily hydrolase, subfamily IA, variant

smcogs: SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000566.5	0.85	ribosomal	streptolysin S	Streptococcus pyogenes M1 GAS
BGC0000564.5	0.62	ribosomal	clostridiolysin S	Clostridium botulinum A str. ATCC 3502
BGC0001170.5	0.60	ribosomal	clostridiolysin S	Clostridium sporogenes ATCC 15579
BGC0001173.5	0.49	ribosomal	plantazolicin	Bacillus pumilus ATCC 7061
BGC0000569.5	0.48	ribosomal	plantazolicin	Bacillus velezensis FZB42
BGC0000605.5	0.41	ribosomal	GE37468	Streptomyces sp. ATCC 55365
BGC0002700.2	0.41	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0001887.3	0.39	ribosomal	huazacin	Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0002111.3	0.39	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0000579.4	0.37	ribosomal	SSV-2083	Streptomyces sviceus ATCC 29083

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000566.5	0.85	ribosomal	streptolysin S	Streptococcus pyogenes M1 GAS
BGC0000564.5	0.62	ribosomal	clostridiolysin S	Clostridium botulinum A str. ATCC 3502
BGC0001170.5	0.60	ribosomal	clostridiolysin S	Clostridium sporogenes ATCC 15579
BGC0001173.5	0.49	ribosomal	plantazolicin	Bacillus pumilus ATCC 7061
BGC0000569.5	0.48	ribosomal	plantazolicin	Bacillus velezensis FZB42
BGC0000605.5	0.41	ribosomal	GE37468	Streptomyces sp. ATCC 55365
BGC0002700.2	0.41	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0001887.3	0.39	ribosomal	huazacin	Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0002111.3	0.39	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0000579.4	0.37	ribosomal	SSV-2083	Streptomyces sviceus ATCC 29083

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.28 out of 26.06

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.39 out of 19.26

Confidence: strong

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.30 out of 25.31

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.32 out of 27.78

Confidence: medium

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.50 out of 26.85

Confidence: medium

Additional weak hits (1):

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.00 out of 30.98

Confidence: weak

(Thi)azol(in)e containing peptide predictions

No core peptides found.

RREFinder

TFBS Finder

Azole RiPPs

RRE predictions

: RRE type: Cytolysin_C_RRE; Location: 0 - 90; Score: 115.1

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
CatR	H2O2-responsive repressor
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MogR	Repressor of flagellar motility genes
RutR	Regulator of the pyrimidine and purine metabolism

Core peptide predictions

No core peptides found.