Select genomic region:
Overview
9.1
9.2
11.1
12.1
12.2

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_BLIS01000009.1 (Streptococcus canis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 9.1 | terpene-precursor | 43,028 | 63,900 |
Region 9.2 | lanthipeptide-class-ii | 133,530 | 161,332 | Medium | lacticin 3147 A1/lacticin 3147 A2 | ribosomal:RiPP:Lanthipeptide

NZ_BLIS01000011.1 (Streptococcus canis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 11.1 | terpene-precursor | 133,901 | 154,899 |

NZ_BLIS01000012.1 (Streptococcus canis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 12.1 | T3PKS | 1 | 29,969 |
Region 12.2 | azole-containing-RiPP | 136,448 | 160,210 | High | streptolysin S | ribosomal:RiPP:LAP

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 9.1 | terpene-precursor | 43,028 | 63,900 |
Region 9.2 | lanthipeptide-class-ii | 133,530 | 161,332 | Medium | lacticin 3147 A1/lacticin 3147 A2 | ribosomal:RiPP:Lanthipeptide
Region 11.1 | terpene-precursor | 133,901 | 154,899 |
Region 12.1 | T3PKS | 1 | 29,969 |
Region 12.2 | azole-containing-RiPP | 136,448 | 160,210 | High | streptolysin S | ribosomal:RiPP:LAP

No secondary metabolite regions were found in these records:
  NZ_BLIS01000001.1 (Streptococcus canis)
  NZ_BLIS01000002.1 (Streptococcus canis)
  NZ_BLIS01000003.1 (Streptococcus canis)
  NZ_BLIS01000004.1 (Streptococcus canis)
  NZ_BLIS01000005.1 (Streptococcus canis)
  NZ_BLIS01000006.1 (Streptococcus canis)
  NZ_BLIS01000007.1 (Streptococcus canis)
  NZ_BLIS01000008.1 (Streptococcus canis)
  NZ_BLIS01000010.1 (Streptococcus canis)
  NZ_BLIS01000013.1 (Streptococcus canis)
  NZ_BLIS01000014.1 (Streptococcus canis)
  NZ_BLIS01000015.1 (Streptococcus canis)
  NZ_BLIS01000016.1 (Streptococcus canis)
  NZ_BLIS01000017.1 (Streptococcus canis)
  NZ_BLIS01000018.1 (Streptococcus canis)
  NZ_BLIS01000019.1 (Streptococcus canis)
  NZ_BLIS01000021.1 (Streptococcus canis)
  NZ_BLIS01000022.1 (Streptococcus canis)
  NZ_BLIS01000023.1 (Streptococcus canis)
  NZ_BLIS01000025.1 (Streptococcus canis)
  NZ_BLIS01000026.1 (Streptococcus canis)
  NZ_BLIS01000028.1 (Streptococcus canis)
  NZ_BLIS01000030.1 (Streptococcus canis)
  NZ_BLIS01000031.1 (Streptococcus canis)
  NZ_BLIS01000032.1 (Streptococcus canis)
  NZ_BLIS01000034.1 (Streptococcus canis)
  NZ_BLIS01000035.1 (Streptococcus canis)
  NZ_BLIS01000037.1 (Streptococcus canis)

Compact view
NZ_BLIS01000009.1 - Region 1 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 43,028 - 63,900 nt. (total: 20,873 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: deaminase
GVO03_RS04370: ornithine cyclodeaminase

smcogs
  SMCOG1158: ornithine cyclodeaminase

Ligases: synthetase
GVO03_RS04400: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.38 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0001605.3 |  | 0.32 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0000633.3 |  | 0.31 | terpene | carotenoid | Streptomyces avermitilis
BGC0001227.3 |  | 0.31 | terpene | isorenieratene | Streptomyces collinus Tu 365
BGC0000648.3 |  | 0.31 | terpene | carotenoid | Myxococcus xanthus
BGC0001456.3 |  | 0.30 | terpene | isorenieratene | Streptomyces argillaceus
BGC0001529.5 |  | 0.30 | other (other) | benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K | Streptomyces sp. RI18
BGC0001756.3 |  | 0.28 | terpene | retigeranin, arathanatriene | Arabidopsis thaliana

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.38 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0001605.3 |  | 0.32 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0000633.3 |  | 0.31 | terpene | carotenoid | Streptomyces avermitilis
BGC0001227.3 |  | 0.31 | terpene | isorenieratene | Streptomyces collinus Tu 365
BGC0000648.3 |  | 0.31 | terpene | carotenoid | Myxococcus xanthus
BGC0001456.3 |  | 0.30 | terpene | isorenieratene | Streptomyces argillaceus
BGC0001529.5 |  | 0.30 | other (other) | benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K | Streptomyces sp. RI18
BGC0001756.3 |  | 0.28 | terpene | retigeranin, arathanatriene | Arabidopsis thaliana

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
GVO03_RS04400: PT_FPPS_like
Domain 1 (25 - 282): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  IPP, DMAPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.00 out of 26.85
Confidence: medium
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.67 out of 25.31
Confidence: medium
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 26.23 out of 28.14
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.54 out of 28.19
Confidence: medium
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CatR | H2O2-responsive repressor
PerR | Peroxide regulator
RutR | Regulator of the pyrimidine and purine metabolism
ZuR variant 1 | Zinc-responsive repressor

NZ_BLIS01000009.1 - Region 2 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 133,530 - 161,332 nt. (total: 27,803 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
GVO03_RS04845: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs
  SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Hydrolases: peptidase
GVO03_RS04780: methionine aminopeptidase

smcogs
  SMCOG1172: methionine aminopeptidase

Lyases: cyclase
GVO03_RS04830: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

GVO03_RS04840: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000520.5 |  | 0.77 | ribosomal | lacticin 3147 A1, lacticin 3147 A2 | Lactococcus lactis
BGC0000555.3 |  | 0.71 | ribosomal | staphylococcin C55 α, staphylococcin C55 β | Staphylococcus aureus
BGC0002110.3 |  | 0.61 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0000497.3 |  | 0.54 | ribosomal | BHT-Aα, BHT-Aβ | Streptococcus ratti
BGC0000623.3 |  | 0.54 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0001229.4 |  | 0.53 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0001210.5 |  | 0.52 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0001391.3 |  | 0.51 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni
BGC0000517.4 |  | 0.51 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000552.3 |  | 0.50 | ribosomal | SmbA, SmbB | Streptococcus mutans

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000520.5 |  | 0.77 | ribosomal | lacticin 3147 A1, lacticin 3147 A2 | Lactococcus lactis
BGC0000555.3 |  | 0.71 | ribosomal | staphylococcin C55 α, staphylococcin C55 β | Staphylococcus aureus
BGC0002110.3 |  | 0.61 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0000497.3 |  | 0.54 | ribosomal | BHT-Aα, BHT-Aβ | Streptococcus ratti
BGC0000623.3 |  | 0.54 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0001229.4 |  | 0.53 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1
BGC0001210.5 |  | 0.52 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0001391.3 |  | 0.51 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni
BGC0000517.4 |  | 0.51 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0000552.3 |  | 0.50 | ribosomal | SmbA, SmbB | Streptococcus mutans

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for GVO03_RS04830

GVO03_RS04820
Leader:
MDKHSEVTLENEILFQEFDEDVFGA
Core:
C T T N T F S L S D Y W G N K G N W C T L T H E C M N W C K
Core with dehydrations:
Cys Dhb Dhb N Dhb F Dha L Dha D Y W G N K G N W Cys Dhb L Dhb H E Cys M N W Cys K

#### antiSMASH-DB 4.0 matches for GVO03_RS04820

100.0%
NZ_BLIS01000009.1 and 7 others:
NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04820_lanthipeptide NZ_LR134317.1 Lanthipeptides: EL136_RS01685_lanthipeptide NZ_LR134317.1 Lanthipeptides: EL136_RS01685_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02620_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02620_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01935_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01935_lanthipeptide
Lanthipeptides: GVO03_RS04820_lanthipeptide
1
C T T N T F S L S D Y W G N K G N W C T L T H E C M N W C K
30
C T T N T F S L S D Y W G N K G N W C T L T H E C M N W C K
1
C T T N T F S L S D Y W G N K G N W C T L T H E C M N W C K
30
93.3%
NZ_AP026714.1 and 21 others:
NZ_AP026714.1 Lanthipeptides: PO853_RS06515_lanthipeptide NZ_CP028724.1 Lanthipeptides: C7I31_RS11265_lanthipeptide NZ_CP028724.1 Lanthipeptides: C7I31_RS11265_lanthipeptide NZ_CP092907.1 Lanthipeptides: MK744_RS03985_lanthipeptide NZ_CP092907.1 Lanthipeptides: MK744_RS03985_lanthipeptide NZ_KB944759.1 Lanthipeptides: WOA_RS09810_lanthipeptide NZ_KB944759.1 Lanthipeptides: WOA_RS09810_lanthipeptide NZ_KZ845892.1 Lanthipeptides: EB42_RS00085_lanthipeptide NZ_KZ845892.1 Lanthipeptides: EB42_RS00085_lanthipeptide NZ_KZ845958.1 Lanthipeptides: EB53_RS07700_lanthipeptide NZ_KZ845958.1 Lanthipeptides: EB53_RS07700_lanthipeptide NZ_LR607361.1 Lanthipeptides: FN738_RS03735_lanthipeptide NZ_LR607361.1 Lanthipeptides: FN738_RS03735_lanthipeptide NZ_LR607378.1 Lanthipeptides: FN751_RS00120_lanthipeptide NZ_LR607378.1 Lanthipeptides: FN751_RS00120_lanthipeptide NZ_LSFS01000007.1 Lanthipeptides: AW733_RS07750_lanthipeptide NZ_LSFS01000007.1 Lanthipeptides: AW733_RS07750_lanthipeptide NZ_NGMP01000002.1 Lanthipeptides: A5830_RS04675_lanthipeptide NZ_NGMP01000002.1 Lanthipeptides: A5830_RS04675_lanthipeptide NZ_NGMV01000001.1 Lanthipeptides: A5824_RS07990_lanthipeptide NZ_NGMV01000001.1 Lanthipeptides: A5824_RS07990_lanthipeptide
Lanthipeptides: PO853_RS06515_lanthipeptide
1
C T T N T F S L S D Y W G N K G N W C T L T H E C M N W C K
30
C T T N T F S L S D Y W G N K G N W C T T H E C M W C K
1
C T T N T F S L S D Y W G N K G N W C T A T H E C M G W C K
30
90.0%
NZ_CP061868.1 and 1 other:
NZ_CP061868.1 Lanthipeptides: IE339_RS06330_lanthipeptide
Lanthipeptides: IE339_RS06330_lanthipeptide
1
C T T N T F S L S D Y W G N K G N W C T L T H E C M N W C K
30
C T T N T F S L S D Y W G N K G W C T T H E C M+W C K
1
C T T N T F S L S D Y W G N K G G W C T A T H E C M S W C K
30
with 107 more sequence matches
Only the first 10 are displayed here.
90.0%
NZ_PCGR01000003.1 and 1 other:
NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09620_lanthipeptide
Lanthipeptides: CQS04_RS09620_lanthipeptide
1
C T T N T F S L S D Y W G N K G N W C T L T H E C M N W C K
30
C T T N T F S L S D Y W G N G N W C T T H E C M+W C K
1
C T T N T F S L S D Y W G N N G N W C T A T H E C M S W C K
30
86.7%
NZ_CACZYW010000004.1 and 1 other:
NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02825_lanthipeptide
Lanthipeptides: HUF10_RS02825_lanthipeptide
1
C T T N T F S L S D Y W G N K G N W C T L T H E C M N W C K
30
C+T N T F S L S D Y W G N G N W C T L+H E C M W C K
1
C S T N T F S L S D Y W G N N G N W C T L S H E C M A W C K
30
86.7%
NZ_CP027862.1 and 1 other:
NZ_CP027862.1 Lanthipeptides: allorf_0097945_0098112_lanthipeptide
Lanthipeptides: allorf_0097945_0098112_lanthipeptide
1
C T T N T F S L S D Y W G N K G N W C T L T H E C M N W C K
30
C+T N T F S L S D Y W G N+G W C T L T H E C M+W C K
1
C S T N T F S L S D Y W G N R G Y W C T L T H E C M S W C K
30
86.7%
NZ_QGEE01000020.1 and 5 others:
NZ_QGEE01000020.1 Lanthipeptides: DKP74_RS06160_lanthipeptide NZ_QGEF01000018.1 Lanthipeptides: DKP75_RS05595_lanthipeptide NZ_QGEF01000018.1 Lanthipeptides: DKP75_RS05595_lanthipeptide NZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05380_lanthipeptide NZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05380_lanthipeptide
Lanthipeptides: DKP74_RS06160_lanthipeptide
1
C T T N T F S L S D Y W G N K G N W C T L T H E C M N W C K
30
C+T N T F S L S D Y W G N+G N W C T L+H E C M W C K
1
C S T N T F S L S D Y W G N R G N W C T L S H E C M A W C K
30
83.3%
NZ_CP034414.1 and 1 other:
NZ_CP034414.1 Lanthipeptides: EI692_RS18440_lanthipeptide
Lanthipeptides: EI692_RS18440_lanthipeptide
1
C T T N T F S L S D Y W G N K G N W C T L T H E C M N W C K
30
C+T N T F S L S D Y W G N K G W C T++H E C M+W C K
1
C S T N T F S L S D Y W G N K G G W C T I S H E C M S W C K
30
83.3%
NZ_FMPI01000012.1 and 1 other:
NZ_FMPI01000012.1 Lanthipeptides: BJR39_RS08305_lanthipeptide
Lanthipeptides: BJR39_RS08305_lanthipeptide
1
C T T N T F S L S D Y W G N K G N W C T L T H E C M N W C K
30
C+T N T F S L S D Y W G N G N W C T +H E C M+W C K
1
C S T N T F S L S D Y W G N N G N W C T A S H E C M S W C K
30
83.3%
NZ_MIFN01000022.1 and 1 other:
NZ_MIFN01000022.1 Lanthipeptides: BHL26_RS15350_lanthipeptide
Lanthipeptides: BHL26_RS15350_lanthipeptide
1
C T T N T F S L S D Y W G N K G N W C T L T H E C M N W C K
30
C T T N T F S L S D Y W G N G+W C+L+H E C M+W C K
1
C T T N T F S L S D Y W G N D G S W C S L S H E C M S W C K
30
83.3%
NZ_NUIO01000031.1 and 1 other:
NZ_NUIO01000031.1 Lanthipeptides: CN977_RS23160_lanthipeptide
Lanthipeptides: CN977_RS23160_lanthipeptide
1
C T T N T F S L S D Y W G N K G N W C T L T H E C M N W C K
30
C T T N T F S L S D Y W G N G+W C T T H E C++W C K
1
C T T N T F S L S D Y W G N D G S W C T A T H E C L S W C K
30
80.0%
NZ_CP016767.1 and 11 others:
NZ_CP016767.1 Lanthipeptides: BCV50_RS13410_lanthipeptide NZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15325_lanthipeptide NZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15325_lanthipeptide NZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07920_lanthipeptide NZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07920_lanthipeptide NZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00580_lanthipeptide NZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00580_lanthipeptide NZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17015_lanthipeptide NZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17015_lanthipeptide NZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04645_lanthipeptide NZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04645_lanthipeptide
Lanthipeptides: BCV50_RS13410_lanthipeptide
1
C T T N T F S L S D Y W G N K G N W C T L T H E C M N W C
29
C T T N T F S L S D Y W G N K G W C T++ E C M W C
1
C T T N T F S L S D Y W G N K G G W C T V S K E C M A W C
29
80.0%
NZ_CP051884.1 and 2 others:
NZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptide NZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptide
Lanthipeptides: HGK68_RS15125_lanthipeptide
1
C T T N T F S L S D Y W G N K G N W C T L T H E C M N W C K
30
C+T N T F S L S D Y W G N G C T+T H E C M+W C K
1
C S T N T F S L S D Y W G N N G W L C T I T H E C M S W C K
30

#### MIBiG 4.0 matches for GVO03_RS04820

66.7%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
1
C T T N T F S L S D Y W G N K G N W C T L T H E C M N W C
29
C T T N T F S L S+ G N G W C T L T E C C
1
C T T N T F S L S N A L G N N G G W C T L T K E C Q P N C
29
43.3%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
6
F S L S D Y W G N K G N W C T L T H E C M N W C
29
+++S G N K G +C T L T E C M C
4
Y N I S C R L G N K G A Y C T L T V E C M P S C
27
15.4%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
19
C T L T H E C M N W C
29
C T L+ E C C
28
C T L S K E C Q P N C
38
GVO03_RS04825
Leader:
MEQNNLELGKYLESDLLSLTDENVDGG
Core:
T T P A S P A T P Y T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
Core with dehydrations:
Dhb Dhb P A Dha P A Dhb P Y Dhb P A I G K G V I A V Dhb A F V Dha A N Dhb Cys P Dhb Dha A Cys Dhb R A Cys

#### antiSMASH-DB 4.0 matches for GVO03_RS04825

100.0%
NZ_BLIS01000009.1 and 1 other:
NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04825_lanthipeptide
Lanthipeptides: GVO03_RS04825_lanthipeptide
1
T T P A S P A T P Y T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
39
T T P A S P A T P Y T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
1
T T P A S P A T P Y T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
39
87.2%
NZ_QRWZ01000002.1 and 3 others:
NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptide
Lanthipeptides: DWX18_RS02625_lanthipeptide
5
S P A T P Y T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
39
+P A T P Y T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
2
T P A T P Y T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
36
61.5%
NZ_LR134317.1 and 1 other:
NZ_LR134317.1 Lanthipeptides: EL136_RS01690_lanthipeptide
Lanthipeptides: EL136_RS01690_lanthipeptide
4
A S P A T P Y T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
39
A S P A T P+ + K +A V T A F+S A N T C P T++C T R A C
1
A S P A T P W---L V K A S V A V T A F I S A N T C P T T S C T R A C
33
with 94 more sequence matches
Only the first 10 are displayed here.
59.0%
NZ_CACZYW010000004.1 and 3 others:
NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptide NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide
Lanthipeptides: HUF10_RS02820_lanthipeptide
1
T T P A S P A T P Y T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
39
T T P A+P A T P ++A V+A+V S T C P T+A C T R A C
1
T T P A T P A T P V-------I V A V S A Y V S D K T C P T T A C T R A C
32
46.2%
NZ_CP033054.1 and 11 others:
NZ_CP033054.1 Lanthipeptides: D9777_RS18840_lanthipeptide NZ_CP047268.1 Lanthipeptides: GKS41_RS18605_lanthipeptide NZ_CP047268.1 Lanthipeptides: GKS41_RS18605_lanthipeptide NZ_CP072563.1 Lanthipeptides: J6600_RS15935_lanthipeptide NZ_CP072563.1 Lanthipeptides: J6600_RS15935_lanthipeptide NZ_CP116014.1 Lanthipeptides: PF996_RS17885_lanthipeptide NZ_CP116014.1 Lanthipeptides: PF996_RS17885_lanthipeptide NZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12560_lanthipeptide NZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12560_lanthipeptide NZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01365_lanthipeptide NZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01365_lanthipeptide
Lanthipeptides: D9777_RS18840_lanthipeptide
4
A S P A T P-Y T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
39
A+P A T T I G T +S A +C P T S A C T+ C
1
A T P A T V V L T A T I G L T G T T F T V T L S A A S C P T S A C T K Q C
37
46.2%
NZ_CP034414.1 and 1 other:
NZ_CP034414.1 Lanthipeptides: EI692_RS18435_lanthipeptide
Lanthipeptides: EI692_RS18435_lanthipeptide
11
T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
39
T P A I I V+ F+S N T C P++A C T R A C
2
T P A I S---I L V S G F I S T N T C P S T A C T R A C
27
46.2%
NZ_JALAPU010000003.1 and 7 others:
NZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07925_lanthipeptide NZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00585_lanthipeptide NZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00585_lanthipeptide NZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17010_lanthipeptide NZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17010_lanthipeptide NZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04640_lanthipeptide NZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04640_lanthipeptide
Lanthipeptides: MOD17_RS07925_lanthipeptide
10
Y T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
39
+T P A+ V T A++S+N T C P T+A C T R A C
1
W T P A L S----V V T A Y I S S N T C P T T A C T R A C
26
46.2%
NZ_QGEE01000020.1 and 3 others:
NZ_QGEE01000020.1 Lanthipeptides: DKP74_RS06165_lanthipeptide NZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05385_lanthipeptide NZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05385_lanthipeptide
Lanthipeptides: DKP74_RS06165_lanthipeptide
11
T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
39
T P I G + V+ F V S++T C P T+A C T R A C
2
T P V I G Y S A V I V S G F V S S H T C P T T A C T R A C
30
41.0%
NZ_CM000721.1 and 9 others:
NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptide NZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide
Lanthipeptides: BCERE0010_RS29355_lanthipeptide
8
T P Y T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
39
T P T P I I A V T A + C P T+ C T C
8
T P A T P T I I G A T I A V T A S L----C P T T K C T S R C
35
41.0%
NZ_CP016767.1 and 3 others:
NZ_CP016767.1 Lanthipeptides: BCV50_RS13415_lanthipeptide NZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptide NZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptide
Lanthipeptides: BCV50_RS13415_lanthipeptide
10
Y T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
39
+T P A+ +T ++S+N T C P T+A C T R A C
1
W T P A L S----V I T G Y I S S N T C P T T A C T R A C
26
41.0%
NZ_CP017953.1 and 15 others:
NZ_CP017953.1 Lanthipeptides: BAMY_RS16390_lanthipeptide NZ_CP021011.1 Lanthipeptides: B6257_RS06470_lanthipeptide NZ_CP021011.1 Lanthipeptides: B6257_RS06470_lanthipeptide NZ_CP041784.1 Lanthipeptides: FOV14_RS15890_lanthipeptide NZ_CP041784.1 Lanthipeptides: FOV14_RS15890_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS05695_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS05695_lanthipeptide NZ_CP097326.1 Lanthipeptides: M5J22_RS16180_lanthipeptide NZ_CP097326.1 Lanthipeptides: M5J22_RS16180_lanthipeptide NZ_CP097784.1 Lanthipeptides: MF619_RS16150_lanthipeptide NZ_CP097784.1 Lanthipeptides: MF619_RS16150_lanthipeptide NZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11805_lanthipeptide NZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11805_lanthipeptide NZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06815_lanthipeptide NZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06815_lanthipeptide
Lanthipeptides: BAMY_RS16390_lanthipeptide
4
A S P A T P Y T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
39
A+P T I G T +S A +C P T S A C T+ C
1
A T P T V V L T A T I G L T G T T F T V T L S A A S C P T S A C T K Q C
36
41.0%
NZ_CP086141.1 and 1 other:
NZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptide
Lanthipeptides: LL065_RS24780_lanthipeptide
8
T P Y T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
39
T P A I V + T A V S A T S A C T++C
2
T P V V S A I S A T V A S A T A-V S A L F T V T S A C T K S C
32
41.0%
NZ_KE384533.1 and 2 others:
NZ_KE384533.1 Lanthipeptides: K329_RS31315_lanthipeptide NZ_KE384533.1 Lanthipeptides: K329_RS31315_lanthipeptide
Lanthipeptides: K329_RS31315_lanthipeptide
11
T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
39
T P I V V+A+V S N T C P T++C T C
1
T P T I V I S V--V S A Y V S T N T C P T T S C T D E C
27

#### MIBiG 4.0 matches for GVO03_RS04825

30.8%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
17
G V I A V T A F V----S A N T C P T S A C T R A C
39
G++A+ A V S A C P T+ C T C
11
G I V A I Q A G V A V G V S A A F C P T T K C T S R C
37
17.9%
BGC0000582.4 (ADR72962.1):
Linaridin: cypemycin
7
A T P Y T P A I G K G V I
19
A T P T P + + V I
1
A T P A T P T V A Q F V I
13
15.4%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
30
C P T S A C T R A C
39
C P T+ C T C
17
C P T T K C T S K C
26
with 2 more sequence matches
12.8%
BGC0000582.4 (ADR72962.1):
Linaridin: cypemycin
4
A S P A T P
9
A+P A T P
1
A T P A T P
6
10.3%
BGC0000582.4 (ADR72962.1):
Linaridin: cypemycin
2
T P A S P
6
T P A+P
2
T P A T P
6
GVO03_RS04860
Leader:
MKFSYNKLWKLLIDKGWTKSELRQKAGI
Core:
S S S T I A K L G K G E N V T T D I L L K I C I A L D C K I E D I I E I V N S K
Core with dehydrations:
Dha Dha Dha Dhb I A K L G K G E N V Dhb Dhb D I L L K I Cys I A L D Cys K I E D I I E I V N Dha K

#### antiSMASH-DB 4.0 matches for GVO03_RS04860

100.0%
NZ_BLIS01000009.1 and 5 others:
NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04860_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02665_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02665_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01890_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01890_lanthipeptide
Lanthipeptides: GVO03_RS04860_lanthipeptide
1
S S S T I A K L G K G E N V T T D I L L K I C I A L D C K I E D I I E I V N S K
40
S S S T I A K L G K G E N V T T D I L L K I C I A L D C K I E D I I E I V N S K
1
S S S T I A K L G K G E N V T T D I L L K I C I A L D C K I E D I I E I V N S K
40
80.0%
NZ_CP102135.1:
Lanthipeptides: NQZ98_RS01525_lanthipeptide
1
S S S T I A K L G K G E N V T T D I L L K I C I A L D C K I E D I I E I V
37
S S S T I A K L G K G E N V T T D+L L+I C I A L D C I E D I+E I+
1
S S S T I A K L G K G E N V T T D V L L R I C I A L D C D I E D I V E I I
37
32.5%
NZ_QUCI01000001.1:
Lanthipeptides: DW648_RS00980_lanthipeptide
1
S S S T I A K L G K G E-N V T T D I L L K I C I A L D C K I E D I I E I
36
S +T++ + G+ N T + L +C I A L D K E++
1
S R N T V S S I E T G Q F N P T A K L A L V L C I A L D K K F E E L F Y F
37
with 4 more sequence matches
17.5%
NZ_BBZK01000004.1:
Lanthipeptides: BGP73_RS05180_lanthipeptide
19
L L K I C I A L D C K I E D I I
34
L I C L D C+ D++
2
L S A I C R E L D C Q P G D L L
17
17.5%
NZ_CP047936.1:
Lanthipeptides: allorf_0851453_0851611_lanthipeptide
25
A L D C K I E D I I E I V
37
A L C + D+I E I+
9
A L R C F V H D V I E I L
21
17.4%
NC_009621.1 and 4 others:
NZ_CP088111.1 Lanthipeptides: allorf_0786726_0786959_lanthipeptide NZ_NBUK01000063.1 Lanthipeptides: allorf_6661_6894_lanthipeptide NZ_VISX01000063.1 Lanthipeptides: allorf_1862_2095_lanthipeptide NZ_VITA01000039.1 Lanthipeptides: allorf_06616_06849_lanthipeptide
Lanthipeptides: allorf_1020482_1020715_lanthipeptide
10
K G E N V T T D I L L K I C I A L D C
28
+G E N+ T L+K + L C
17
Q G E N M V T K S L I K R L M M L V C
35
12.2%
NZ_SBIS02000007.1:
Lanthipeptides: EPL00_RS13710_lanthipeptide
13
N V T T D I L L K I C I A L D C K I E D I I E
35
+ + ++ K+ D C+I E D+ +
17
D P S I E L A F K L A D H F D C R I E D L F D
39

#### MIBiG 4.0 matches for GVO03_RS04860

10.0%
BGC0000563.4 (AEA03263.1):
Lanthipeptide: venezuelin
18
I L L K I C I A L D C K
29
+L +C I + C
11
L L N T V C I G I S C A
22
GVO03_RS04870
Leader:
MQLPNKLYSYQKSTLAYLPRVLNEIKSGNSNVKDIFHA
Core:
I S E E L D D P T D F L S I M D C L Y A L N A I E M S N E G E V K L C L
Core with dehydrations:
I Dha E E L D D P Dhb D F L Dha I M D Cys L Y A L N A I E M Dha N E G E V K L Cys L

#### antiSMASH-DB 4.0 matches for GVO03_RS04870

100.0%
NZ_BLIS01000009.1 and 6 others:
NZ_CAAHHE010000002.1 Lanthipeptides: E9499_RS03005_lanthipeptide NZ_CAAHHN010000003.1 Lanthipeptides: E9502_RS05635_lanthipeptide NZ_CAAHRY010000002.1 Lanthipeptides: E9986_RS03100_lanthipeptide NZ_CAAIES010000002.1 Lanthipeptides: FAH15_RS02400_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02675_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01880_lanthipeptide
Lanthipeptides: GVO03_RS04870_lanthipeptide
1
I S E E L D D P T D F L S I M D C L Y A L N A I E M S N E G E V K L C L
36
I S E E L D D P T D F L S I M D C L Y A L N A I E M S N E G E V K L C L
1
I S E E L D D P T D F L S I M D C L Y A L N A I E M S N E G E V K L C L
36
97.2%
NZ_CP102135.1:
Lanthipeptides: NQZ98_RS01535_lanthipeptide
1
I S E E L D D P T D F L S I M D C L Y A L N A I E M S N E G E V K L C L
36
I S E E L D D P T D F L S I M D C L Y A L N A I E M S N E G E V L C L
1
I S E E L D D P T D F L S I M D C L Y A L N A I E M S N E G E V N L C L
36
19.4%
NZ_CAKMMP010000011.1:
Lanthipeptides: allorf_219369_219518_lanthipeptide
1
I S E E L D D P T D F L S I M D C
17
I E+L + T ++S+M+C
10
I R E D L C E Q T W W V S L M N C
26

#### Lanthipeptide(s) for GVO03_RS04840

GVO03_RS04820
Leader:
MDKHSEVTLENEILFQEFDEDVFGA
Core:
C T T N T F S L S D Y W G N K G N W C T L T H E C M N W C K
Core with dehydrations:
Cys Dhb Dhb N Dhb F Dha L Dha D Y W G N K G N W Cys Dhb L Dhb H E Cys M N W Cys K

#### antiSMASH-DB 4.0 matches for GVO03_RS04820

100.0%
NZ_BLIS01000009.1 and 7 others:
NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04820_lanthipeptide NZ_LR134317.1 Lanthipeptides: EL136_RS01685_lanthipeptide NZ_LR134317.1 Lanthipeptides: EL136_RS01685_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02620_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02620_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01935_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01935_lanthipeptide
Lanthipeptides: GVO03_RS04820_lanthipeptide
1
C T T N T F S L S D Y W G N K G N W C T L T H E C M N W C K
30
C T T N T F S L S D Y W G N K G N W C T L T H E C M N W C K
1
C T T N T F S L S D Y W G N K G N W C T L T H E C M N W C K
30
93.3%
NZ_AP026714.1 and 21 others:
NZ_AP026714.1 Lanthipeptides: PO853_RS06515_lanthipeptide NZ_CP028724.1 Lanthipeptides: C7I31_RS11265_lanthipeptide NZ_CP028724.1 Lanthipeptides: C7I31_RS11265_lanthipeptide NZ_CP092907.1 Lanthipeptides: MK744_RS03985_lanthipeptide NZ_CP092907.1 Lanthipeptides: MK744_RS03985_lanthipeptide NZ_KB944759.1 Lanthipeptides: WOA_RS09810_lanthipeptide NZ_KB944759.1 Lanthipeptides: WOA_RS09810_lanthipeptide NZ_KZ845892.1 Lanthipeptides: EB42_RS00085_lanthipeptide NZ_KZ845892.1 Lanthipeptides: EB42_RS00085_lanthipeptide NZ_KZ845958.1 Lanthipeptides: EB53_RS07700_lanthipeptide NZ_KZ845958.1 Lanthipeptides: EB53_RS07700_lanthipeptide NZ_LR607361.1 Lanthipeptides: FN738_RS03735_lanthipeptide NZ_LR607361.1 Lanthipeptides: FN738_RS03735_lanthipeptide NZ_LR607378.1 Lanthipeptides: FN751_RS00120_lanthipeptide NZ_LR607378.1 Lanthipeptides: FN751_RS00120_lanthipeptide NZ_LSFS01000007.1 Lanthipeptides: AW733_RS07750_lanthipeptide NZ_LSFS01000007.1 Lanthipeptides: AW733_RS07750_lanthipeptide NZ_NGMP01000002.1 Lanthipeptides: A5830_RS04675_lanthipeptide NZ_NGMP01000002.1 Lanthipeptides: A5830_RS04675_lanthipeptide NZ_NGMV01000001.1 Lanthipeptides: A5824_RS07990_lanthipeptide NZ_NGMV01000001.1 Lanthipeptides: A5824_RS07990_lanthipeptide
Lanthipeptides: PO853_RS06515_lanthipeptide
1
C T T N T F S L S D Y W G N K G N W C T L T H E C M N W C K
30
C T T N T F S L S D Y W G N K G N W C T T H E C M W C K
1
C T T N T F S L S D Y W G N K G N W C T A T H E C M G W C K
30
90.0%
NZ_CP061868.1 and 1 other:
NZ_CP061868.1 Lanthipeptides: IE339_RS06330_lanthipeptide
Lanthipeptides: IE339_RS06330_lanthipeptide
1
C T T N T F S L S D Y W G N K G N W C T L T H E C M N W C K
30
C T T N T F S L S D Y W G N K G W C T T H E C M+W C K
1
C T T N T F S L S D Y W G N K G G W C T A T H E C M S W C K
30
with 107 more sequence matches
Only the first 10 are displayed here.
90.0%
NZ_PCGR01000003.1 and 1 other:
NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09620_lanthipeptide
Lanthipeptides: CQS04_RS09620_lanthipeptide
1
C T T N T F S L S D Y W G N K G N W C T L T H E C M N W C K
30
C T T N T F S L S D Y W G N G N W C T T H E C M+W C K
1
C T T N T F S L S D Y W G N N G N W C T A T H E C M S W C K
30
86.7%
NZ_CACZYW010000004.1 and 1 other:
NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02825_lanthipeptide
Lanthipeptides: HUF10_RS02825_lanthipeptide
1
C T T N T F S L S D Y W G N K G N W C T L T H E C M N W C K
30
C+T N T F S L S D Y W G N G N W C T L+H E C M W C K
1
C S T N T F S L S D Y W G N N G N W C T L S H E C M A W C K
30
86.7%
NZ_CP027862.1 and 1 other:
NZ_CP027862.1 Lanthipeptides: allorf_0097945_0098112_lanthipeptide
Lanthipeptides: allorf_0097945_0098112_lanthipeptide
1
C T T N T F S L S D Y W G N K G N W C T L T H E C M N W C K
30
C+T N T F S L S D Y W G N+G W C T L T H E C M+W C K
1
C S T N T F S L S D Y W G N R G Y W C T L T H E C M S W C K
30
86.7%
NZ_QGEE01000020.1 and 5 others:
NZ_QGEE01000020.1 Lanthipeptides: DKP74_RS06160_lanthipeptide NZ_QGEF01000018.1 Lanthipeptides: DKP75_RS05595_lanthipeptide NZ_QGEF01000018.1 Lanthipeptides: DKP75_RS05595_lanthipeptide NZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05380_lanthipeptide NZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05380_lanthipeptide
Lanthipeptides: DKP74_RS06160_lanthipeptide
1
C T T N T F S L S D Y W G N K G N W C T L T H E C M N W C K
30
C+T N T F S L S D Y W G N+G N W C T L+H E C M W C K
1
C S T N T F S L S D Y W G N R G N W C T L S H E C M A W C K
30
83.3%
NZ_CP034414.1 and 1 other:
NZ_CP034414.1 Lanthipeptides: EI692_RS18440_lanthipeptide
Lanthipeptides: EI692_RS18440_lanthipeptide
1
C T T N T F S L S D Y W G N K G N W C T L T H E C M N W C K
30
C+T N T F S L S D Y W G N K G W C T++H E C M+W C K
1
C S T N T F S L S D Y W G N K G G W C T I S H E C M S W C K
30
83.3%
NZ_FMPI01000012.1 and 1 other:
NZ_FMPI01000012.1 Lanthipeptides: BJR39_RS08305_lanthipeptide
Lanthipeptides: BJR39_RS08305_lanthipeptide
1
C T T N T F S L S D Y W G N K G N W C T L T H E C M N W C K
30
C+T N T F S L S D Y W G N G N W C T +H E C M+W C K
1
C S T N T F S L S D Y W G N N G N W C T A S H E C M S W C K
30
83.3%
NZ_MIFN01000022.1 and 1 other:
NZ_MIFN01000022.1 Lanthipeptides: BHL26_RS15350_lanthipeptide
Lanthipeptides: BHL26_RS15350_lanthipeptide
1
C T T N T F S L S D Y W G N K G N W C T L T H E C M N W C K
30
C T T N T F S L S D Y W G N G+W C+L+H E C M+W C K
1
C T T N T F S L S D Y W G N D G S W C S L S H E C M S W C K
30
83.3%
NZ_NUIO01000031.1 and 1 other:
NZ_NUIO01000031.1 Lanthipeptides: CN977_RS23160_lanthipeptide
Lanthipeptides: CN977_RS23160_lanthipeptide
1
C T T N T F S L S D Y W G N K G N W C T L T H E C M N W C K
30
C T T N T F S L S D Y W G N G+W C T T H E C++W C K
1
C T T N T F S L S D Y W G N D G S W C T A T H E C L S W C K
30
80.0%
NZ_CP016767.1 and 11 others:
NZ_CP016767.1 Lanthipeptides: BCV50_RS13410_lanthipeptide NZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15325_lanthipeptide NZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15325_lanthipeptide NZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07920_lanthipeptide NZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07920_lanthipeptide NZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00580_lanthipeptide NZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00580_lanthipeptide NZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17015_lanthipeptide NZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17015_lanthipeptide NZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04645_lanthipeptide NZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04645_lanthipeptide
Lanthipeptides: BCV50_RS13410_lanthipeptide
1
C T T N T F S L S D Y W G N K G N W C T L T H E C M N W C
29
C T T N T F S L S D Y W G N K G W C T++ E C M W C
1
C T T N T F S L S D Y W G N K G G W C T V S K E C M A W C
29
80.0%
NZ_CP051884.1 and 2 others:
NZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptide NZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptide
Lanthipeptides: HGK68_RS15125_lanthipeptide
1
C T T N T F S L S D Y W G N K G N W C T L T H E C M N W C K
30
C+T N T F S L S D Y W G N G C T+T H E C M+W C K
1
C S T N T F S L S D Y W G N N G W L C T I T H E C M S W C K
30

#### MIBiG 4.0 matches for GVO03_RS04820

66.7%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
1
C T T N T F S L S D Y W G N K G N W C T L T H E C M N W C
29
C T T N T F S L S+ G N G W C T L T E C C
1
C T T N T F S L S N A L G N N G G W C T L T K E C Q P N C
29
43.3%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
6
F S L S D Y W G N K G N W C T L T H E C M N W C
29
+++S G N K G +C T L T E C M C
4
Y N I S C R L G N K G A Y C T L T V E C M P S C
27
15.4%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
19
C T L T H E C M N W C
29
C T L+ E C C
28
C T L S K E C Q P N C
38
GVO03_RS04825
Leader:
MEQNNLELGKYLESDLLSLTDENVDGG
Core:
T T P A S P A T P Y T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
Core with dehydrations:
Dhb Dhb P A Dha P A Dhb P Y Dhb P A I G K G V I A V Dhb A F V Dha A N Dhb Cys P Dhb Dha A Cys Dhb R A Cys

#### antiSMASH-DB 4.0 matches for GVO03_RS04825

100.0%
NZ_BLIS01000009.1 and 1 other:
NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04825_lanthipeptide
Lanthipeptides: GVO03_RS04825_lanthipeptide
1
T T P A S P A T P Y T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
39
T T P A S P A T P Y T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
1
T T P A S P A T P Y T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
39
87.2%
NZ_QRWZ01000002.1 and 3 others:
NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02625_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01930_lanthipeptide
Lanthipeptides: DWX18_RS02625_lanthipeptide
5
S P A T P Y T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
39
+P A T P Y T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
2
T P A T P Y T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
36
61.5%
NZ_LR134317.1 and 1 other:
NZ_LR134317.1 Lanthipeptides: EL136_RS01690_lanthipeptide
Lanthipeptides: EL136_RS01690_lanthipeptide
4
A S P A T P Y T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
39
A S P A T P+ + K +A V T A F+S A N T C P T++C T R A C
1
A S P A T P W---L V K A S V A V T A F I S A N T C P T T S C T R A C
33
with 94 more sequence matches
Only the first 10 are displayed here.
59.0%
NZ_CACZYW010000004.1 and 3 others:
NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptide NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide
Lanthipeptides: HUF10_RS02820_lanthipeptide
1
T T P A S P A T P Y T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
39
T T P A+P A T P ++A V+A+V S T C P T+A C T R A C
1
T T P A T P A T P V-------I V A V S A Y V S D K T C P T T A C T R A C
32
46.2%
NZ_CP033054.1 and 11 others:
NZ_CP033054.1 Lanthipeptides: D9777_RS18840_lanthipeptide NZ_CP047268.1 Lanthipeptides: GKS41_RS18605_lanthipeptide NZ_CP047268.1 Lanthipeptides: GKS41_RS18605_lanthipeptide NZ_CP072563.1 Lanthipeptides: J6600_RS15935_lanthipeptide NZ_CP072563.1 Lanthipeptides: J6600_RS15935_lanthipeptide NZ_CP116014.1 Lanthipeptides: PF996_RS17885_lanthipeptide NZ_CP116014.1 Lanthipeptides: PF996_RS17885_lanthipeptide NZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12560_lanthipeptide NZ_JAANHO010000006.1 Lanthipeptides: G9F75_RS12560_lanthipeptide NZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01365_lanthipeptide NZ_JAIONG010000001.1 Lanthipeptides: K8B35_RS01365_lanthipeptide
Lanthipeptides: D9777_RS18840_lanthipeptide
4
A S P A T P-Y T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
39
A+P A T T I G T +S A +C P T S A C T+ C
1
A T P A T V V L T A T I G L T G T T F T V T L S A A S C P T S A C T K Q C
37
46.2%
NZ_CP034414.1 and 1 other:
NZ_CP034414.1 Lanthipeptides: EI692_RS18435_lanthipeptide
Lanthipeptides: EI692_RS18435_lanthipeptide
11
T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
39
T P A I I V+ F+S N T C P++A C T R A C
2
T P A I S---I L V S G F I S T N T C P S T A C T R A C
27
46.2%
NZ_JALAPU010000003.1 and 7 others:
NZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07925_lanthipeptide NZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00585_lanthipeptide NZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00585_lanthipeptide NZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17010_lanthipeptide NZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17010_lanthipeptide NZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04640_lanthipeptide NZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04640_lanthipeptide
Lanthipeptides: MOD17_RS07925_lanthipeptide
10
Y T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
39
+T P A+ V T A++S+N T C P T+A C T R A C
1
W T P A L S----V V T A Y I S S N T C P T T A C T R A C
26
46.2%
NZ_QGEE01000020.1 and 3 others:
NZ_QGEE01000020.1 Lanthipeptides: DKP74_RS06165_lanthipeptide NZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05385_lanthipeptide NZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05385_lanthipeptide
Lanthipeptides: DKP74_RS06165_lanthipeptide
11
T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
39
T P I G + V+ F V S++T C P T+A C T R A C
2
T P V I G Y S A V I V S G F V S S H T C P T T A C T R A C
30
41.0%
NZ_CM000721.1 and 9 others:
NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptide NZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide
Lanthipeptides: BCERE0010_RS29355_lanthipeptide
8
T P Y T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
39
T P T P I I A V T A + C P T+ C T C
8
T P A T P T I I G A T I A V T A S L----C P T T K C T S R C
35
41.0%
NZ_CP016767.1 and 3 others:
NZ_CP016767.1 Lanthipeptides: BCV50_RS13415_lanthipeptide NZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptide NZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptide
Lanthipeptides: BCV50_RS13415_lanthipeptide
10
Y T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
39
+T P A+ +T ++S+N T C P T+A C T R A C
1
W T P A L S----V I T G Y I S S N T C P T T A C T R A C
26
41.0%
NZ_CP017953.1 and 15 others:
NZ_CP017953.1 Lanthipeptides: BAMY_RS16390_lanthipeptide NZ_CP021011.1 Lanthipeptides: B6257_RS06470_lanthipeptide NZ_CP021011.1 Lanthipeptides: B6257_RS06470_lanthipeptide NZ_CP041784.1 Lanthipeptides: FOV14_RS15890_lanthipeptide NZ_CP041784.1 Lanthipeptides: FOV14_RS15890_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS05695_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS05695_lanthipeptide NZ_CP097326.1 Lanthipeptides: M5J22_RS16180_lanthipeptide NZ_CP097326.1 Lanthipeptides: M5J22_RS16180_lanthipeptide NZ_CP097784.1 Lanthipeptides: MF619_RS16150_lanthipeptide NZ_CP097784.1 Lanthipeptides: MF619_RS16150_lanthipeptide NZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11805_lanthipeptide NZ_JAAKXX010000011.1 Lanthipeptides: G6H00_RS11805_lanthipeptide NZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06815_lanthipeptide NZ_LMAG01000012.1 Lanthipeptides: ASQ47_RS06815_lanthipeptide
Lanthipeptides: BAMY_RS16390_lanthipeptide
4
A S P A T P Y T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
39
A+P T I G T +S A +C P T S A C T+ C
1
A T P T V V L T A T I G L T G T T F T V T L S A A S C P T S A C T K Q C
36
41.0%
NZ_CP086141.1 and 1 other:
NZ_CP086141.1 Lanthipeptides: LL065_RS24780_lanthipeptide
Lanthipeptides: LL065_RS24780_lanthipeptide
8
T P Y T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
39
T P A I V + T A V S A T S A C T++C
2
T P V V S A I S A T V A S A T A-V S A L F T V T S A C T K S C
32
41.0%
NZ_KE384533.1 and 2 others:
NZ_KE384533.1 Lanthipeptides: K329_RS31315_lanthipeptide NZ_KE384533.1 Lanthipeptides: K329_RS31315_lanthipeptide
Lanthipeptides: K329_RS31315_lanthipeptide
11
T P A I G K G V I A V T A F V S A N T C P T S A C T R A C
39
T P I V V+A+V S N T C P T++C T C
1
T P T I V I S V--V S A Y V S T N T C P T T S C T D E C
27

#### MIBiG 4.0 matches for GVO03_RS04825

30.8%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
17
G V I A V T A F V----S A N T C P T S A C T R A C
39
G++A+ A V S A C P T+ C T C
11
G I V A I Q A G V A V G V S A A F C P T T K C T S R C
37
17.9%
BGC0000582.4 (ADR72962.1):
Linaridin: cypemycin
7
A T P Y T P A I G K G V I
19
A T P T P + + V I
1
A T P A T P T V A Q F V I
13
15.4%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
30
C P T S A C T R A C
39
C P T+ C T C
17
C P T T K C T S K C
26
with 2 more sequence matches
12.8%
BGC0000582.4 (ADR72962.1):
Linaridin: cypemycin
4
A S P A T P
9
A+P A T P
1
A T P A T P
6
10.3%
BGC0000582.4 (ADR72962.1):
Linaridin: cypemycin
2
T P A S P
6
T P A+P
2
T P A T P
6
GVO03_RS04860
Leader:
MKFSYNKLWKLLIDKGWTKSELRQKAGI
Core:
S S S T I A K L G K G E N V T T D I L L K I C I A L D C K I E D I I E I V N S K
Core with dehydrations:
Dha Dha Dha Dhb I A K L G K G E N V Dhb Dhb D I L L K I Cys I A L D Cys K I E D I I E I V N Dha K

#### antiSMASH-DB 4.0 matches for GVO03_RS04860

100.0%
NZ_BLIS01000009.1 and 5 others:
NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04860_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02665_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02665_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01890_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01890_lanthipeptide
Lanthipeptides: GVO03_RS04860_lanthipeptide
1
S S S T I A K L G K G E N V T T D I L L K I C I A L D C K I E D I I E I V N S K
40
S S S T I A K L G K G E N V T T D I L L K I C I A L D C K I E D I I E I V N S K
1
S S S T I A K L G K G E N V T T D I L L K I C I A L D C K I E D I I E I V N S K
40
80.0%
NZ_CP102135.1:
Lanthipeptides: NQZ98_RS01525_lanthipeptide
1
S S S T I A K L G K G E N V T T D I L L K I C I A L D C K I E D I I E I V
37
S S S T I A K L G K G E N V T T D+L L+I C I A L D C I E D I+E I+
1
S S S T I A K L G K G E N V T T D V L L R I C I A L D C D I E D I V E I I
37
32.5%
NZ_QUCI01000001.1:
Lanthipeptides: DW648_RS00980_lanthipeptide
1
S S S T I A K L G K G E-N V T T D I L L K I C I A L D C K I E D I I E I
36
S +T++ + G+ N T + L +C I A L D K E++
1
S R N T V S S I E T G Q F N P T A K L A L V L C I A L D K K F E E L F Y F
37
with 4 more sequence matches
17.5%
NZ_BBZK01000004.1:
Lanthipeptides: BGP73_RS05180_lanthipeptide
19
L L K I C I A L D C K I E D I I
34
L I C L D C+ D++
2
L S A I C R E L D C Q P G D L L
17
17.5%
NZ_CP047936.1:
Lanthipeptides: allorf_0851453_0851611_lanthipeptide
25
A L D C K I E D I I E I V
37
A L C + D+I E I+
9
A L R C F V H D V I E I L
21
17.4%
NC_009621.1 and 4 others:
NZ_CP088111.1 Lanthipeptides: allorf_0786726_0786959_lanthipeptide NZ_NBUK01000063.1 Lanthipeptides: allorf_6661_6894_lanthipeptide NZ_VISX01000063.1 Lanthipeptides: allorf_1862_2095_lanthipeptide NZ_VITA01000039.1 Lanthipeptides: allorf_06616_06849_lanthipeptide
Lanthipeptides: allorf_1020482_1020715_lanthipeptide
10
K G E N V T T D I L L K I C I A L D C
28
+G E N+ T L+K + L C
17
Q G E N M V T K S L I K R L M M L V C
35
12.2%
NZ_SBIS02000007.1:
Lanthipeptides: EPL00_RS13710_lanthipeptide
13
N V T T D I L L K I C I A L D C K I E D I I E
35
+ + ++ K+ D C+I E D+ +
17
D P S I E L A F K L A D H F D C R I E D L F D
39

#### MIBiG 4.0 matches for GVO03_RS04860

10.0%
BGC0000563.4 (AEA03263.1):
Lanthipeptide: venezuelin
18
I L L K I C I A L D C K
29
+L +C I + C
11
L L N T V C I G I S C A
22
GVO03_RS04870
Leader:
MQLPNKLYSYQKSTLAYLPRVLNEIKSGNSNVKDIFHA
Core:
I S E E L D D P T D F L S I M D C L Y A L N A I E M S N E G E V K L C L
Core with dehydrations:
I Dha E E L D D P Dhb D F L Dha I M D Cys L Y A L N A I E M Dha N E G E V K L Cys L

#### antiSMASH-DB 4.0 matches for GVO03_RS04870

100.0%
NZ_BLIS01000009.1 and 6 others:
NZ_CAAHHE010000002.1 Lanthipeptides: E9499_RS03005_lanthipeptide NZ_CAAHHN010000003.1 Lanthipeptides: E9502_RS05635_lanthipeptide NZ_CAAHRY010000002.1 Lanthipeptides: E9986_RS03100_lanthipeptide NZ_CAAIES010000002.1 Lanthipeptides: FAH15_RS02400_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02675_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01880_lanthipeptide
Lanthipeptides: GVO03_RS04870_lanthipeptide
1
I S E E L D D P T D F L S I M D C L Y A L N A I E M S N E G E V K L C L
36
I S E E L D D P T D F L S I M D C L Y A L N A I E M S N E G E V K L C L
1
I S E E L D D P T D F L S I M D C L Y A L N A I E M S N E G E V K L C L
36
97.2%
NZ_CP102135.1:
Lanthipeptides: NQZ98_RS01535_lanthipeptide
1
I S E E L D D P T D F L S I M D C L Y A L N A I E M S N E G E V K L C L
36
I S E E L D D P T D F L S I M D C L Y A L N A I E M S N E G E V L C L
1
I S E E L D D P T D F L S I M D C L Y A L N A I E M S N E G E V N L C L
36
19.4%
NZ_CAKMMP010000011.1:
Lanthipeptides: allorf_219369_219518_lanthipeptide
1
I S E E L D D P T D F L S I M D C
17
I E+L + T ++S+M+C
10
I R E D L C E Q T W W V S L M N C
26

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.75 out of 29.38
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.95 out of 27.78
Confidence: strong
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.71 out of 28.19
Confidence: strong
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.18 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.47 out of 28.19
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.05 out of 18.16
Confidence: strong
Additional weak hits (4):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.91 out of 29.38
Confidence: weak
CsoR
Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 20.43 out of 32.38
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.54 out of 29.25
Confidence: weak
BldD
Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.51 out of 23.43
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

GVO03_RS04820 - Class II
  Cleavage pHMM score: 2.00
  RODEO score: 0
  Monoisotopic mass: 3416.5 Da
  Molecular weight: 3418.8 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3436.8 Da N = 1
    3454.8 Da N = 2
    3472.9 Da N = 3
GVO03_RS04825 - Class II
  Cleavage pHMM score: -2.60
  RODEO score: 0
  Monoisotopic mass: 3597.9 Da
  Molecular weight: 3600.1 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3618.1 Da N = 1
    3636.1 Da N = 2
    3654.2 Da N = 3
    3672.2 Da N = 4
    3690.2 Da N = 5
    3708.2 Da N = 6
    3726.2 Da N = 7
    3744.3 Da N = 8
GVO03_RS04860 - Class II
  Cleavage pHMM score: -6.60
  RODEO score: 0
  Monoisotopic mass: 4161.3 Da
  Molecular weight: 4163.9 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4181.9 Da N = 1
    4199.9 Da N = 2
    4217.9 Da N = 3
    4235.9 Da N = 4
    4254.0 Da N = 5
GVO03_RS04870 - Class II
  Cleavage pHMM score: -7.00
  RODEO score: 0
  Monoisotopic mass: 3960.9 Da
  Molecular weight: 3963.5 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3981.5 Da N = 1
    3999.5 Da N = 2
GVO03_RS04820 - Class II
  Cleavage pHMM score: 2.00
  RODEO score: 0
  Monoisotopic mass: 3416.5 Da
  Molecular weight: 3418.8 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3436.8 Da N = 1
    3454.8 Da N = 2
    3472.9 Da N = 3
GVO03_RS04825 - Class II
  Cleavage pHMM score: -2.60
  RODEO score: 0
  Monoisotopic mass: 3597.9 Da
  Molecular weight: 3600.1 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3618.1 Da N = 1
    3636.1 Da N = 2
    3654.2 Da N = 3
    3672.2 Da N = 4
    3690.2 Da N = 5
    3708.2 Da N = 6
    3726.2 Da N = 7
    3744.3 Da N = 8
GVO03_RS04860 - Class II
  Cleavage pHMM score: -6.60
  RODEO score: 0
  Monoisotopic mass: 4161.3 Da
  Molecular weight: 4163.9 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4181.9 Da N = 1
    4199.9 Da N = 2
    4217.9 Da N = 3
    4235.9 Da N = 4
    4254.0 Da N = 5
GVO03_RS04870 - Class II
  Cleavage pHMM score: -7.00
  RODEO score: 0
  Monoisotopic mass: 3960.9 Da
  Molecular weight: 3963.5 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3981.5 Da N = 1
    3999.5 Da N = 2

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1 | Ferric Uptake Regulator
ZuR variant 1 | Zinc-responsive repressor

NZ_BLIS01000011.1 - Region 1 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 133,901 - 154,899 nt. (total: 20,999 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Ligases: synthetase
GVO03_RS06270: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000623.3 |  | 0.43 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000547.5 |  | 0.39 | ribosomal | salivaricin 9 | Streptococcus salivarius
BGC0002116.3 |  | 0.38 | ribosomal | darobactin A | Photorhabdus khanii HGB 1456
BGC0001789.3 |  | 0.37 | ribosomal | suicin 90-1330 | Streptococcus suis
BGC0000536.3 |  | 0.37 | ribosomal | nisin Q | Lactococcus lactis
BGC0000537.3 |  | 0.37 | ribosomal | nisin U | Streptococcus uberis
BGC0000556.5 |  | 0.37 | ribosomal | streptin | Streptococcus pyogenes
BGC0000515.4 |  | 0.37 | ribosomal | geobacillin I | Geobacillus thermodenitrificans NG80-2
BGC0000535.4 |  | 0.37 | ribosomal | nisin A | Lactococcus lactis subsp. lactis
BGC0000506.4 |  | 0.37 | ribosomal | entianin | Bacillus subtilis subsp. spizizenii

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000623.3 |  | 0.43 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000547.5 |  | 0.39 | ribosomal | salivaricin 9 | Streptococcus salivarius
BGC0002116.3 |  | 0.38 | ribosomal | darobactin A | Photorhabdus khanii HGB 1456
BGC0001789.3 |  | 0.37 | ribosomal | suicin 90-1330 | Streptococcus suis
BGC0000536.3 |  | 0.37 | ribosomal | nisin Q | Lactococcus lactis
BGC0000537.3 |  | 0.37 | ribosomal | nisin U | Streptococcus uberis
BGC0000556.5 |  | 0.37 | ribosomal | streptin | Streptococcus pyogenes
BGC0000515.4 |  | 0.37 | ribosomal | geobacillin I | Geobacillus thermodenitrificans NG80-2
BGC0000535.4 |  | 0.37 | ribosomal | nisin A | Lactococcus lactis subsp. lactis
BGC0000506.4 |  | 0.37 | ribosomal | entianin | Bacillus subtilis subsp. spizizenii

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP
diterpene precursor |  | GGPP | C20 | acyclic | PP
sesterterpene precursor |  | GFPP | C25 | acyclic | PP
triterpene precursor |  | HPP | C30 | acyclic | PP

Genes with terpene domains:
GVO03_RS06270: PT_FPPS_like
Domain 1 (39 - 315): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: unknown

Reactions:
  IPP, DMAPP → FPP
  IPP, DMAPP → GGPP
  IPP, DMAPP → GFPP
  IPP, DMAPP → HPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.95 out of 27.78
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.06 out of 20.97
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.87 out of 26.06
Confidence: medium
Additional weak hits (4):
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.70 out of 27.55
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.48 out of 28.14
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.99 out of 30.22
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 24.96 out of 36.53
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
GFPP | Geranylfarnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
HPP | Hexaprenyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MogR | Repressor of flagellar motility genes

NZ_BLIS01000012.1 - Region 1 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 29,969 nt. (total: 29,969 nt) Show pHMM detection rules used
Region on contig edge.
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: reductase
GVO03_RS06885: hydroxymethylglutaryl-CoA reductase

smcogs
  SMCOG1187: hydroxymethylglutaryl-CoA reductase

Hydrolases: deformylase esterase
GVO03_RS06925: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase

smcogs
  SMCOG1283: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase

GVO03_RS06930: peptide deformylase

smcogs
  SMCOG1275: peptide deformylase

Ligases: synthase
GVO03_RS06880: hydroxymethylglutaryl-CoA synthase

smcogs
  SMCOG1043: hydroxymethylglutaryl-CoA synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000501.3 |  | 0.48 | ribosomal | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0002561.3 |  | 0.44 | other (other) | phenazine SA, phenazine SB, phenazine SC | Streptomyces sp.
BGC0000851.5 |  | 0.43 | other (other) | albonoursin | Streptomyces noursei ATCC 11455
BGC0002306.2 |  | 0.43 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000551.5 |  | 0.42 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000513.3 |  | 0.41 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0000563.4 |  | 0.41 | ribosomal | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0002699.2 |  | 0.41 | ribosomal | nostolysamide A, nostolysamide B | Nostoc punctiforme PCC 73102
BGC0000519.4 |  | 0.41 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000286.3 |  | 0.40 | PKS | viguiepinol | Streptomyces sp. KO-3988

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000501.3 |  | 0.48 | ribosomal | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0002561.3 |  | 0.44 | other (other) | phenazine SA, phenazine SB, phenazine SC | Streptomyces sp.
BGC0000851.5 |  | 0.43 | other (other) | albonoursin | Streptomyces noursei ATCC 11455
BGC0002306.2 |  | 0.43 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000551.5 |  | 0.42 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000513.3 |  | 0.41 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0000563.4 |  | 0.41 | ribosomal | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0002699.2 |  | 0.41 | ribosomal | nostolysamide A, nostolysamide B | Nostoc punctiforme PCC 73102
BGC0000519.4 |  | 0.41 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000286.3 |  | 0.40 | PKS | viguiepinol | Streptomyces sp. KO-3988

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.49 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.77 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.33 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.11 out of 26.06
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.40 out of 20.97
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.00 out of 27.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.63 out of 28.19
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 15.96 out of 18.16
Confidence: strong
Additional weak hits (3):
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 24.12 out of 36.53
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.33 out of 29.25
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.96 out of 29.25
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MogR | Repressor of flagellar motility genes
ZuR variant 1 | Zinc-responsive repressor

NZ_BLIS01000012.1 - Region 2 - azole-containing-RiPP
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
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Location: 136,448 - 160,210 nt. (total: 23,763 nt) Show pHMM detection rules used
azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
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Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Azole RiPPs
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: hydrolase
GVO03_RS07550: HAD-superfamily hydrolase, subfamily IA, variant

smcogs
  SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | azole-containing-RiPP | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000566.5 |  | 0.85 | ribosomal | streptolysin S | Streptococcus pyogenes M1 GAS
BGC0000564.5 |  | 0.62 | ribosomal | clostridiolysin S | Clostridium botulinum A str. ATCC 3502
BGC0001170.5 |  | 0.60 | ribosomal | clostridiolysin S | Clostridium sporogenes ATCC 15579
BGC0001173.5 |  | 0.49 | ribosomal | plantazolicin | Bacillus pumilus ATCC 7061
BGC0000569.5 |  | 0.48 | ribosomal | plantazolicin | Bacillus velezensis FZB42
BGC0000605.5 |  | 0.41 | ribosomal | GE37468 | Streptomyces sp. ATCC 55365
BGC0002700.2 |  | 0.41 | ribosomal | bacinapeptin | Bacillus nakamurai
BGC0001887.3 |  | 0.39 | ribosomal | huazacin | Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0002111.3 |  | 0.39 | ribosomal | andalusicin A, andalusicin B | Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0000579.4 |  | 0.37 | ribosomal | SSV-2083 | Streptomyces sviceus ATCC 29083

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000566.5 |  | 0.85 | ribosomal | streptolysin S | Streptococcus pyogenes M1 GAS
BGC0000564.5 |  | 0.62 | ribosomal | clostridiolysin S | Clostridium botulinum A str. ATCC 3502
BGC0001170.5 |  | 0.60 | ribosomal | clostridiolysin S | Clostridium sporogenes ATCC 15579
BGC0001173.5 |  | 0.49 | ribosomal | plantazolicin | Bacillus pumilus ATCC 7061
BGC0000569.5 |  | 0.48 | ribosomal | plantazolicin | Bacillus velezensis FZB42
BGC0000605.5 |  | 0.41 | ribosomal | GE37468 | Streptomyces sp. ATCC 55365
BGC0002700.2 |  | 0.41 | ribosomal | bacinapeptin | Bacillus nakamurai
BGC0001887.3 |  | 0.39 | ribosomal | huazacin | Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0002111.3 |  | 0.39 | ribosomal | andalusicin A, andalusicin B | Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0000579.4 |  | 0.37 | ribosomal | SSV-2083 | Streptomyces sviceus ATCC 29083

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.28 out of 26.06
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.39 out of 19.26
Confidence: strong
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.30 out of 25.31
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.32 out of 27.78
Confidence: medium
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.50 out of 26.85
Confidence: medium
Additional weak hits (1):
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.00 out of 30.98
Confidence: weak
(Thi)azol(in)e containing peptide predictions
Lists the possible core peptides for each biosynthetic enzyme. Predicted tail sequences are also shown, if present.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.
No core peptides found.
RREFinder
TFBS Finder
Azole RiPPs
RRE predictions
RREfinder results sidepanel.

azole-containing-RiPP protocluster (136447...160210)
GVO03_RS07510
  RRE type: Cytolysin_C_RRE
  Location: 0 - 90
  Score: 115.1

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
CatR | H2O2-responsive repressor
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MogR | Repressor of flagellar motility genes
RutR | Regulator of the pyrimidine and purine metabolism

Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its possible molecular weights and the scores for cleavage site prediction and RODEO. If relevant, other features, such as macrocycle and amidation, will also be listed.
No core peptides found.