GCF_004765815.2 - 13 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_ML974127.1 (Halorussus salinus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	NI-siderophore	184,920	218,977	Medium	schizokinen	NRPS:Type IV
Region 1.2	terpene	433,666	454,613
Region 1.3	lanthipeptide-class-ii	475,603	498,899
Region 1.4	terpene	782,126	803,079
Region 1.5	lanthipeptide-class-ii	1,455,720	1,479,109
Region 1.6	azole-containing-RiPP,lanthipeptide-class-ii	1,527,162	1,568,330	High	archalan α	ribosomal:RiPP
Region 1.7	terpene-precursor	1,573,391	1,585,202

NZ_ML974128.1 (Halorussus salinus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 2.1	terpene	100,544	120,885
Region 2.2	RiPP-like	355,327	367,147

NZ_SBIS02000007.1 (Halorussus salinus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 3.1	lanthipeptide-class-ii	22,163	45,384
Region 3.2	azole-containing-RiPP	354,479	378,801

NZ_ML974129.1 (Halorussus salinus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 5.1	terpene	208,496	229,578

NZ_SBIS02000011.1 (Halorussus salinus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 6.1	lanthipeptide-class-ii,triceptide,terpene-precursor	167,395	233,689	High	archalan β	ribosomal:RiPP

No secondary metabolite regions were found in these records:: NZ_SBIS02000008.1 (Halorussus salinus); NZ_SBIS02000012.1 (Halorussus salinus); NZ_SBIS02000013.1 (Halorussus salinus); NZ_SBIS02000014.1 (Halorussus salinus); NZ_SBIS02000015.1 (Halorussus salinus); NZ_SBIS02000016.1 (Halorussus salinus)

Compact view

NZ_ML974127.1 - Region 1 - NI-siderophore

Download region GenBank file

Download region SVG

Location: 184,920 - 218,977 nt. (total: 34,058 nt) Show pHMM detection rules used

NI-siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase oxygenase

EPL00_RS01000: lysine/ornithine N-monooxygenase

smcogs: SMCOG1080: lysine/ornithine N-monooxygenase

EPL00_RS01015: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

Transferases: aminotransferase

EPL00_RS00980: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Lyases: decarboxylase

EPL00_RS00985: Decarboxylase, pyridoxal-dependent

smcogs: SMCOG1180: Decarboxylase, pyridoxal-dependent

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002469.2	0.67	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0002633.2	0.66	other (other)	schizokinen	Leptolyngbya sp. PCC 7376
BGC0002683.2	0.65	NRPS	schizokinen	Nostoc sp. PCC 7120 = FACHB-418
BGC0001572.3	0.64	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0002692.2	0.64	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0001478.5	0.61	other (other)	desferrioxamine E	Streptomyces sp. ID38640
BGC0000941.3	0.60	other (other)	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002305.2	0.59	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0002470.2	0.58	other (other)	synechobactin C9, synechobactin C11, synechobactin 13, synechobactin 14, synechobactin 16, synechobactin A, synechobactin B, synechobactin C	Synechococcus sp. PCC 7002
BGC0001713.5	0.57	other (other)	ochrobactin	Ochrobactrum anthropi

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002469.2	0.67	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0002633.2	0.66	other (other)	schizokinen	Leptolyngbya sp. PCC 7376
BGC0002683.2	0.65	NRPS	schizokinen	Nostoc sp. PCC 7120 = FACHB-418
BGC0001572.3	0.64	other (other)	desferrioxamine E	Pantoea agglomerans
BGC0002692.2	0.64	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0001478.5	0.61	other (other)	desferrioxamine E	Streptomyces sp. ID38640
BGC0000941.3	0.60	other (other)	desferrioxamin B	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002305.2	0.59	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0002470.2	0.58	other (other)	synechobactin C9, synechobactin C11, synechobactin 13, synechobactin 14, synechobactin 16, synechobactin A, synechobactin B, synechobactin C	Synechococcus sp. PCC 7002
BGC0001713.5	0.57	other (other)	ochrobactin	Ochrobactrum anthropi

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

NZ_ML974127.1 - Region 2 - terpene

Download region GenBank file

Download region SVG

Location: 433,666 - 454,613 nt. (total: 20,948 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase reductase

EPL00_RS02210: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

EPL00_RS02275: alkyl hydroperoxide reductase/ Thiol specific

smcogs: SMCOG1196: alkyl hydroperoxide reductase/ Thiol specific

Transferases: glycosyltransferase

EPL00_RS02200: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

Hydrolases: hydrolase

EPL00_RS02175: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

EPL00_RS02190: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

Similar gene clusters

Analysis type:

Reference	terpene	Similarity score	Type	Compound(s)	Organism
BGC0001410.3		0.40	saccharide	polysaccharide A	Bacteroides fragilis
BGC0001195.3		0.27	NRPS, PKS	nocardiopsin A, nocardiopsin B, nocardiopsin C, nocardiopsin D	Nocardiopsis sp. CMB-M0232

Reference	Aggregated	Similarity score	Type	Compound(s)	Organism
BGC0001410.3		0.40	saccharide	polysaccharide A	Bacteroides fragilis
BGC0001195.3		0.27	NRPS, PKS	nocardiopsin A, nocardiopsin B, nocardiopsin C, nocardiopsin D	Nocardiopsis sp. CMB-M0232

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
tetraterpene	C40 carotenoid		C40	unknown	unknown

Genes with terpene domains:

EPL00_RS02225: Lycopene_cycl + Lycopene_cycl

Domain 1 (6 - 97): Lycopene cyclase

Reactions:: C40_carotenoid → C40_carotenoid

Domain 2 (170 - 258): Lycopene cyclase

Reactions:: C40_carotenoid → C40_carotenoid

Terpene

Glossary

No acronyms to display

NZ_ML974127.1 - Region 3 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 475,603 - 498,899 nt. (total: 23,297 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

EPL00_RS02450: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002703.2	0.49	ribosomal	archalan α	Halorussus salinus
BGC0000554.4	0.48	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001579.4	0.47	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0000528.5	0.46	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001226.4	0.44	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0000563.4	0.44	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0000503.5	0.43	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0002704.2	0.42	ribosomal	archalan β	Halorussus salinus
BGC0001660.3	0.41	ribosomal	mathermycin	Marinactinospora thermotolerans
BGC0001210.5	0.41	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002703.2	0.49	ribosomal	archalan α	Halorussus salinus
BGC0000554.4	0.48	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001579.4	0.47	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0000528.5	0.46	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001226.4	0.44	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0000563.4	0.44	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0000503.5	0.43	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0002704.2	0.42	ribosomal	archalan β	Halorussus salinus
BGC0001660.3	0.41	ribosomal	mathermycin	Marinactinospora thermotolerans
BGC0001210.5	0.41	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for EPL00_RS02450

EPL00_RS02405

Leader:

MDESLLADWVRRSPSLDAILDSSARTAISDDFVPDDLLAEWRDVFDADADFRDRLRFA

Core:

DWTPEETCDRPNPSEII

Core with dehydrations:

DWDhbPEEDhbCysDRPNPDhaEII

antiSMASH-DB 4.0 matches for EPL00_RS02405

100.0%

NZ_ML974127.1:

Lanthipeptides: EPL00_RS02405_lanthipeptide

1

DWTPEETCDRPNPSEII

17

DWTPEETCDRPNPSEII

1

DWTPEETCDRPNPSEII

17

33.3%

NZ_CP117416.1and 5 others:

NZ_CP117876.1 Lassopeptides: PQ460_RS19020_lassopeptideNZ_CP117876.1 Lassopeptides: PQ460_RS19030_lassopeptideNZ_JAQQZQ010000001.1 Lassopeptides: PO903_RS10225_lassopeptideNZ_JAQQZQ010000001.1 Lassopeptides: PO903_RS10220_lassopeptideNZ_JAQQZQ010000001.1 Lassopeptides: PO903_RS10215_lassopeptide

Lassopeptides: PQ456_RS04840_lassopeptide

1

DWTPEETCDRPNPS

14

DW E+ D NPS

8

DWVSEQDADLYNPS

21

33.3%

NZ_CP117876.1:

Lassopeptides: PQ460_RS19025_lassopeptide

1

DWTPEETCDRPNPS

14

DW E D NPS

8

DWVSEHDADLFNPS

21

with 12 more sequence matches

Only the first 10 are displayed here.

31.8%

NZ_FNNT01000001.1:

Lassopeptides: BLW49_RS28475_lassopeptide

1

DWTPEETCDRPNPS

14

DW E D NPS

9

DWISEHDGDLYNPS

22

28.6%

NC_014483.2and 10 others:

NC_023037.2 Lassopeptides: X809_RS27480_lassopeptideNZ_CP011420.1 Lassopeptides: VK72_RS27415_lassopeptideNZ_CP017967.2 Lassopeptides: PPYC1_RS06115_lassopeptideNZ_CP017968.3 Lassopeptides: PPYC2_RS06795_lassopeptideNZ_CP073682.1 Lassopeptides: KAI36_RS06145_lassopeptideNZ_CP073683.1 Lassopeptides: KAI37_RS05910_lassopeptideNZ_CP109848.1 Lassopeptides: OF859_RS24335_lassopeptideNZ_CP113973.1 Lassopeptides: OYT09_RS06050_lassopeptideNZ_FOYG01000001.1 Lassopeptides: BM358_RS26180_lassopeptideNZ_PTJM01000055.1 Lassopeptides: C5G87_RS12815_lassopeptide

Lassopeptides: PPE_RS25060_lassopeptide

1

DWTPEETCDRPNPS

14

DW + D NPS

8

DWVSDHDADLHNPS

21

28.6%

NC_014622.2and 26 others:

NC_016641.1 Lassopeptides: HPL003_RS28495_lassopeptideNC_017542.1 Lassopeptides: PPM_RS29155_lassopeptideNZ_CP006872.1 Lassopeptides: PPSQR21_RS25845_lassopeptideNZ_CP020028.1 Lassopeptides: B4V02_RS25945_lassopeptideNZ_CP023711.1 Lassopeptides: CPY53_RS20730_lassopeptideNZ_CP025696.1 Lassopeptides: C0638_RS25110_lassopeptideNZ_CP025957.1 Lassopeptides: C1A50_RS25040_lassopeptideNZ_CP029370.1 Lassopeptides: DI243_RS05990_lassopeptideNZ_CP034141.1 Lassopeptides: EGM68_RS06425_lassopeptideNZ_CP040829.1 Lassopeptides: FGY93_RS02005_lassopeptideNZ_CP041731.1 Lassopeptides: FOA15_RS11830_lassopeptideNZ_CP042272.1 Lassopeptides: FQU75_RS22710_lassopeptideNZ_CP049598.1 Lassopeptides: G7L40_RS02540_lassopeptideNZ_CP084033.1 Lassopeptides: LAZ93_RS06040_lassopeptideNZ_CP085682.1 Lassopeptides: LJR53_RS05900_lassopeptideNZ_CP086373.1 Lassopeptides: LMH85_RS06275_lassopeptideNZ_CP092779.1 Lassopeptides: MJ749_RS05940_lassopeptideNZ_CP097766.1 Lassopeptides: MF620_RS06000_lassopeptideNZ_CP102865.1 Lassopeptides: NWS42_RS19270_lassopeptideNZ_FNYX01000001.1 Lassopeptides: BMY87_RS25010_lassopeptideNZ_JAOYTP010000002.1 Lassopeptides: OIU26_RS08460_lassopeptideNZ_JWJJ01000002.1 Lassopeptides: U707_RS25590_lassopeptideNZ_LNZF01000001.1 Lassopeptides: AVK83_RS26330_lassopeptideNZ_PNXP01000013.1 Lassopeptides: C1I59_RS05635_lassopeptideNZ_PNXQ01000012.1 Lassopeptides: C1I60_RS12180_lassopeptideNZ_POVT01000017.1 Lassopeptides: C1T20_RS25045_lassopeptide

Lassopeptides: PPSC2_RS58945_lassopeptide

1

DWTPEETCDRPNPS

14

DW + D NPS

8

DWVSDHDADLYNPS

21

28.6%

NZ_BMMB01000001.1and 4 others:

NZ_BMMB01000001.1 Lassopeptides: IEX62_RS00125_lassopeptideNZ_CP013023.1 Lassopeptides: AR543_RS24045_lassopeptideNZ_KQ040793.1 Lassopeptides: WH45_RS23340_lassopeptideNZ_KQ040798.1 Lassopeptides: WH46_RS23990_lassopeptide

Lassopeptides: IEX62_RS00120_lassopeptide

1

DWTPEETCDRPNPS

14

DW + D NPS

8

DWVTYDDADLYNPS

21

28.6%

NZ_CP013203.1:

Lassopeptides: ASL14_RS05780_lassopeptide

1

DWTPEETCDRPNPS

14

DW + D NPS

8

DWVSDHDADLVNPS

21

28.6%

NZ_CP015423.1and 9 others:

NZ_CP061172.1 Lassopeptides: IAQ67_RS05910_lassopeptideNZ_CP071875.1 Lassopeptides: J4I02_RS06550_lassopeptideNZ_CP092831.1 Lassopeptides: MLD56_RS06365_lassopeptideNZ_JAAMNR010000001.1 Lassopeptides: G9G54_RS05075_lassopeptideNZ_JAFJXZ010000012.1 Lassopeptides: JYU28_RS05205_lassopeptideNZ_JAKVDC010000001.1 Lassopeptides: MKN04_RS01225_lassopeptideNZ_JANAVI010000007.1 Lassopeptides: NLX74_RS16260_lassopeptideNZ_JANAVN010000010.1 Lassopeptides: NLX78_RS16305_lassopeptideNZ_POVS01000014.1 Lassopeptides: C1T21_RS27040_lassopeptide

Lassopeptides: AOU00_RS26345_lassopeptide

1

DWTPEETCDRPNPS

14

DW + D NPS

8

DWVSDHDADIYNPS

21

28.6%

NZ_CP033873.1:

Lassopeptides: CSW63_RS23970_lassopeptide

1

DWTPEETCDRP

11

D+ PE +C+RP

4

DFIPEFSCERP

14

28.6%

NZ_CP117416.1:

Lassopeptides: PQ456_RS04830_lassopeptide

1

DWTPEETCDRPNPS

14

DW ++ D NPS

8

DWVSDQDADLYNPS

21

27.3%

NZ_CP118101.1and 2 others:

NZ_CP118106.1 Lassopeptides: PUW24_RS15770_lassopeptideNZ_FPAC01000001.1 Lassopeptides: BM415_RS24635_lassopeptide

Lassopeptides: PUW23_RS08415_lassopeptide

1

DWTPEETCDRPNPS

14

DW E D +PS

9

DWISEHDADLYDPS

22

18.8%

NZ_FNDJ01000037.1:

Lanthipeptides: allorf_006346_006582_lanthipeptide

4

PEETCDRPNP

13

P TC RP P

20

PAATCRRPAP

29

allorf_0489183_0489356

Leader:

MASRRTVVSSVVHAVRVALHAVITG

Core:

VCGSPNRRGRRRGGNRSPCERRGWVLSLDKIF

Core with dehydrations:

VCysGDhaPNRRGRRRGGNRDhaPCysERRGWVLDhaLDKIF

antiSMASH-DB 4.0 matches for allorf_0489183_0489356

100.0%

NZ_ML974127.1:

Lanthipeptides: allorf_0489183_0489356_lanthipeptide

1

VCGSPNRRGRRRGGNRSPCERRGWVLSLDKIF

32

VCGSPNRRGRRRGGNRSPCERRGWVLSLDKIF

1

VCGSPNRRGRRRGGNRSPCERRGWVLSLDKIF

32

32.4%

NZ_CP041604.2and 3 others:

NZ_CP041610.2 Lanthipeptides: allorf_00763119_00763355_lanthipeptideNZ_CP041611.1 Lanthipeptides: allorf_00813099_00813335_lanthipeptideNZ_CP041650.2 Lanthipeptides: allorf_01115923_01116159_lanthipeptide

Lanthipeptides: allorf_01200858_01201094_lanthipeptide

9

GRRRG--GNRSPCERR

22

GRRR G+RSPC RR

10

GRRRPWPGHRSPCPRR

25

28.6%

NZ_FOWL01000011.1:

Lanthipeptides: allorf_022376_022519_lanthipeptide

8

RGRRRGGNRSPCERRGWVLSL

28

R R+G P RRGW SL

7

RAARQGPETGPGRRRGWAFSL

27

with 3 more sequence matches

18.8%

NZ_CP011130.1:

Lanthipeptides: allorf_5346585_5346695_lanthipeptide

14

GNRSPCERRGWV

25

GN PC R W

4

GNSGPCASRAWT

15

15.6%

NZ_LUCO01000008.1:

Lanthipeptides: allorf_089261_089395_lanthipeptide

19

CERRGWVLS

27

CER ++LS

9

CEREAYILS

17

13.8%

NZ_CP003987.1:

Lanthipeptides: allorf_00516755_00516991_lanthipeptide

4

SPNRRGRRRGGNRSPC

19

SP RRRGG PC

27

SPGSLARRRGGATCPC

42

allorf_0493198_0493422

Leader:

MRGASRRICERWNREQGSGG

Core:

YVGQRPRACGGFLRPRLRLRPRLRQHRQHRRRFRRLRTQQRQHSHGLRRPRPQL

Core with dehydrations:

YVGQRPRACysGGFLRPRLRLRPRLRQHRQHRRRFRRLRDhbQQRQHDhaHGLRRPRPQL

antiSMASH-DB 4.0 matches for allorf_0493198_0493422

100.0%

NZ_ML974127.1:

Lanthipeptides: allorf_0493198_0493422_lanthipeptide

1

YVGQRPRACGGFLRPRLRLRPRLRQHRQHRRRFRRLRTQQRQHSHGLRRPRPQL

54

YVGQRPRACGGFLRPRLRLRPRLRQHRQHRRRFRRLRTQQRQHSHGLRRPRPQL

1

YVGQRPRACGGFLRPRLRLRPRLRQHRQHRRRFRRLRTQQRQHSHGLRRPRPQL

54

20.4%

NZ_LZRD01000031.1:

Lanthipeptides: allorf_12002_12133_lanthipeptide

9

CGG----FLRPRLRLRPRLRQHRQHRRRF

33

CGG L PR R RPR+ R+ +

2

CGGPLVTVLAPRPRDRPRVTSGRKPWKAV

30

18.5%

NZ_RAII01000001.1:

Lanthipeptides: allorf_2955953_2956186_lanthipeptide

34

RRLRTQQRQHSHGLRRPRPQL

54

R R Q RQH+ +RPR +L

17

RTTRGQWRQHAVTAKRPRARL

37

with 1 more sequence matches

13.0%

NZ_CP071090.1:

Lanthipeptides: allorf_11048315_11048452_lanthipeptide

3

GQRPRACGGFLRPRLRLRPRLRQHRQHRRRFRRL

36

G+RPR C P +R + + + +

1

GERPRVCKSIQAPTHAMRCTVVTSKTYVETTTAI

34

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

EPL00_RS02405 - Class II

Cleavage pHMM score: -5.60

RODEO score: 0

Monoisotopic mass: 1946.9 Da

Molecular weight: 1948.1 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1966.1 Da N = 1; 1984.1 Da N = 2

allorf_0489183_0489356 - Class II

Cleavage pHMM score: -5.90

RODEO score: 0

Monoisotopic mass: 3629.9 Da

Molecular weight: 3632.1 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3650.2 Da N = 1

allorf_0493198_0493422 - Class II

Cleavage pHMM score: -6.10

RODEO score: 0

Monoisotopic mass: 6815.9 Da

Molecular weight: 6819.9 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 6837.9 Da N = 1

NZ_ML974127.1 - Region 4 - terpene

Download region GenBank file

Download region SVG

Location: 782,126 - 803,079 nt. (total: 20,954 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: deacetylase

EPL00_RS04045: acetylornithine deacetylase

smcogs: SMCOG1247: acetylornithine deacetylase

Lyases: decarboxylase lyase

EPL00_RS04025: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

EPL00_RS04055: diaminopimelate decarboxylase

smcogs: SMCOG1264: diaminopimelate decarboxylase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000645.3	0.42	terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0002645.3	0.40	other (other)	fluopsin C	Pseudomonas aeruginosa PAO1
BGC0000664.5	0.40	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000633.3	0.40	terpene	carotenoid	Streptomyces avermitilis
BGC0001227.3	0.39	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0001456.3	0.39	terpene	isorenieratene	Streptomyces argillaceus
BGC0000648.3	0.37	terpene	carotenoid	Myxococcus xanthus
BGC0000663.5	0.36	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0000494.5	0.33	ribosomal	uberolysin	Streptococcus uberis
BGC0002499.2	0.30	NRPS, PKS	enteromycin	Streptomyces achromogenes subsp. streptozoticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000645.3	0.42	terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0002645.3	0.40	other (other)	fluopsin C	Pseudomonas aeruginosa PAO1
BGC0000664.5	0.40	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000633.3	0.40	terpene	carotenoid	Streptomyces avermitilis
BGC0001227.3	0.39	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0001456.3	0.39	terpene	isorenieratene	Streptomyces argillaceus
BGC0000648.3	0.37	terpene	carotenoid	Myxococcus xanthus
BGC0000663.5	0.36	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0000494.5	0.33	ribosomal	uberolysin	Streptococcus uberis
BGC0002499.2	0.30	NRPS, PKS	enteromycin	Streptomyces achromogenes subsp. streptozoticus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	C30 carotenoid	diapophytoene	C30	acyclic	none
triterpene		squalene	C30	acyclic	none
triterpene		PSPP	C30	acyclic	PP
tetraterpene	C40 carotenoid	phytoene	C40	acyclic	none
triterpene		hydroxysqualene	C30	acyclic	OH

Genes with terpene domains:

EPL00_RS04015: PT_phytoene_like

Domain 1 (8 - 280): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → diapophytoene; FPP → squalene; FPP → PSPP; GGPP → phytoene; PSPP → hydroxysqualene

Terpene

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
PP	Diphosphate
PSPP	Presqualene diphosphate

NZ_ML974127.1 - Region 5 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 1,455,720 - 1,479,109 nt. (total: 23,390 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: methyltransferase

EPL00_RS07370: methyltransferase

smcogs: SMCOG1089: methyltransferase

Lyases: cyclase

EPL00_RS07375: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001217.5	0.52	other (other)	PreQ0 Base	Streptomyces qinglanensis
BGC0002704.2	0.51	ribosomal	archalan β	Halorussus salinus
BGC0002703.2	0.50	ribosomal	archalan α	Halorussus salinus
BGC0000554.4	0.48	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001579.4	0.47	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0000802.5	0.46	saccharide	succinoglycan	Sinorhizobium meliloti
BGC0000528.5	0.46	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000563.4	0.44	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0001226.4	0.44	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0001210.5	0.43	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001217.5	0.52	other (other)	PreQ0 Base	Streptomyces qinglanensis
BGC0002704.2	0.51	ribosomal	archalan β	Halorussus salinus
BGC0002703.2	0.50	ribosomal	archalan α	Halorussus salinus
BGC0000554.4	0.48	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001579.4	0.47	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0000802.5	0.46	saccharide	succinoglycan	Sinorhizobium meliloti
BGC0000528.5	0.46	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000563.4	0.44	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0001226.4	0.44	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0001210.5	0.43	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for EPL00_RS07375

EPL00_RS07380

Leader:

MAVSDGPPIGIRHPTVNPTPDAAIAQSRSGA

Core:

CECVDCGYVVGTDDDLPPKCPDCGGALTFVRS

Core with dehydrations:

CysECysVDCysGYVVGDhbDDDLPPKCysPDCysGGALDhbFVRDha

antiSMASH-DB 4.0 matches for EPL00_RS07380

100.0%

NZ_ML974127.1:

Lanthipeptides: EPL00_RS07380_lanthipeptide

1

CECVDCGYVVGTDDDLPPKCPDCGGALTFVRS

32

CECVDCGYVVGTDDDLPPKCPDCGGALTFVRS

1

CECVDCGYVVGTDDDLPPKCPDCGGALTFVRS

32

25.6%

NZ_CP096019.1:

Lanthipeptides: MW046_RS07405_lanthipeptide

2

ECVDCGYVVGTDD------DLPP-----KCPDCGGALTFVR

31

C++CG+ D +PP +CP+CG R

2

RCLNCGFEAPHDGGEWNSAQVPPLGDLMRCPECGSTNILGR

42

17.4%

NZ_CP096019.1:

Lanthipeptides: MW046_RS07480_lanthipeptide

15

DLPPKCPDCGGALTFV

30

D +CPDCGG + V

5

DTDRECPDCGGPVVSV

20

with 2 more sequence matches

16.7%

NZ_BNBJ01000003.1and 3 others:

NZ_CP079114.1 Lanthipeptides: allorf_4422232_4422378_lanthipeptideNZ_JALDPQ010000054.1 Lanthipeptides: allorf_130072_130218_lanthipeptideNZ_JAMFLF010000021.1 Lanthipeptides: allorf_031162_031308_lanthipeptide

Lanthipeptides: allorf_023668_023814_lanthipeptide

19

KCPDCGGALTFV

30

+CP GGA F+

10

RCPSEGGAEEFI

21

15.2%

NZ_CP096658.1and 1 other:

NZ_ML974127.1 Lanthipeptides: EPL00_RS07765_lanthipeptide

Lanthipeptides: M0R88_RS16185_lanthipeptide

19

KCPDCGGALTFV

30

+CPDCGG + V

9

ECPDCGGDVLEV

20

allorf_1457905_1457976

Leader:

MSAEKPSEDEFRGA

Core:

SESRHRCGV

Core with dehydrations:

DhaEDhaRHRCysGV

antiSMASH-DB 4.0 matches for allorf_1457905_1457976

100.0%

NZ_ML974127.1:

Lanthipeptides: allorf_1457905_1457976_lanthipeptide

1

SESRHRCGV

9

SESRHRCGV

1

SESRHRCGV

9

25.0%

NZ_KB900614.1:

Lanthipeptides: allorf_2951591_2951809_lanthipeptide

1

SESRHRCG

8

+E R+RCG

5

AEVRYRCG

12

allorf_1470722_1470832

Leader:

MPISSIDLIQSPQLPSSAYS

Core:

RVYQEGLSVFRTCRLS

Core with dehydrations:

RVYQEGLDhaVFRDhbCysRLDha

antiSMASH-DB 4.0 matches for allorf_1470722_1470832

100.0%

NZ_ML974127.1:

Lanthipeptides: allorf_1470722_1470832_lanthipeptide

1

RVYQEGLSVFRTCRLS

16

RVYQEGLSVFRTCRLS

1

RVYQEGLSVFRTCRLS

16

24.1%

NZ_FMTR01000020.1and 4 others:

NZ_FMXH01000021.1 Lanthipeptides: allorf_013379_013498_lanthipeptideNZ_FNNL01000019.1 Lanthipeptides: allorf_013061_013180_lanthipeptideNZ_FNYG01000024.1 Lanthipeptides: allorf_013147_013266_lanthipeptideNZ_FOTH01000039.1 Lanthipeptides: allorf_32773_32892_lanthipeptide

Lanthipeptides: allorf_013814_013933_lanthipeptide

1

RVYQEGLSVF

10

RV ++GLSVF

17

RVCRKGLSVF

26

allorf_1476445_1476564

Leader:

MVGERCRILVHCPRPGGTRTSDGS

Core:

RIQCQWLPVLATHRA

Core with dehydrations:

RIQCysQWLPVLADhbHRA

antiSMASH-DB 4.0 matches for allorf_1476445_1476564

100.0%

NZ_ML974127.1:

Lanthipeptides: allorf_1476445_1476564_lanthipeptide

1

RIQCQWLPVLATHRA

15

RIQCQWLPVLATHRA

1

RIQCQWLPVLATHRA

15

18.5%

NZ_SWMS01000001.1:

Lassopeptides: allorf_785281_785463_lassopeptide

3

QCQWLPVLA

11

WLPVL

10

NLSWLPVLG

18

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

EPL00_RS07380 - Class II

Cleavage pHMM score: -6.80

RODEO score: 0

Monoisotopic mass: 3279.4 Da

Molecular weight: 3281.7 Da

Number of bridges: 3

allorf_1457905_1457976 - Class II

Cleavage pHMM score: -6.60

RODEO score: 0

Monoisotopic mass: 993.5 Da

Molecular weight: 994.1 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1012.1 Da N = 1

allorf_1470722_1470832 - Class II

Cleavage pHMM score: -6.10

RODEO score: 0

Monoisotopic mass: 1859.0 Da

Molecular weight: 1860.1 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1878.2 Da N = 1; 1896.2 Da N = 2

allorf_1476445_1476564 - Class II

Cleavage pHMM score: -7.00

RODEO score: 0

Monoisotopic mass: 1773.0 Da

Molecular weight: 1774.1 Da

Number of bridges: 1

NZ_ML974127.1 - Region 6 - azole-containing-RiPP,lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 1,527,162 - 1,568,330 nt. (total: 41,169 nt) Show pHMM detection rules used

azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

Azole RiPPs

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

EPL00_RS07660: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: aminotransferase

EPL00_RS07700: aminotransferase

smcogs: SMCOG1019: aminotransferase

Lyases: cyclase

EPL00_RS07790: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Ligases: synthase

EPL00_RS07690: carbamoyl phosphate synthase small subunit

smcogs: SMCOG1249: carbamoyl phosphate synthase small subunit

Translocases: permease

EPL00_RS07740: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002703.2	0.78	ribosomal	archalan α	Halorussus salinus
BGC0000554.4	0.17	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001937.4	0.16	other (other)	tubercidin	Streptomyces tubercidicus
BGC0002013.4	0.15	ribosomal	curacozole	Streptomyces curacoi
BGC0000881.3	0.15	other (other)	toyocamycin	Streptomyces ahygroscopicus subsp. wuzhouensis
BGC0001808.5	0.15	other (other)	toyocamycin	Streptomyces diastatochromogenes
BGC0000041.3	0.13	PKS	oronofacic acid	Pseudomonas syringae
BGC0002031.3	0.13	other (other)	kitasetaline	Kitasatospora setae KM-6054
BGC0002704.2	0.13	ribosomal	archalan β	Halorussus salinus
BGC0000504.5	0.13	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002703.2	0.92	ribosomal	archalan α	Halorussus salinus
BGC0000554.4	0.48	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0002704.2	0.47	ribosomal	archalan β	Halorussus salinus
BGC0000504.5	0.46	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0002013.4	0.45	ribosomal	curacozole	Streptomyces curacoi
BGC0000517.4	0.44	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0002699.2	0.43	ribosomal	nostolysamide A, nostolysamide B	Nostoc punctiforme PCC 73102
BGC0000041.3	0.42	PKS	oronofacic acid	Pseudomonas syringae
BGC0002031.3	0.42	other (other)	kitasetaline	Kitasatospora setae KM-6054
BGC0001187.4	0.41	NRPS, PKS	xenolozoyenone	Glarea lozoyensis

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for EPL00_RS07790

EPL00_RS07765

Leader:

MADNRVVQGRMVTPAALAEMIEGEDVMDA

Core:

EAISETDRECPDCGGDVLEVGYMPSVTEFVTGWKCQDCDWADTDRD

Core with dehydrations:

EAIDhaEDhbDRECysPDCysGGDVLEVGYMPDhaVDhbEFVDhbGWKCysQDCysDWADDhbDRD

antiSMASH-DB 4.0 matches for EPL00_RS07765

100.0%

NZ_CP096658.1and 1 other:

NZ_ML974127.1 Lanthipeptides: EPL00_RS07765_lanthipeptide

Lanthipeptides: M0R88_RS16185_lanthipeptide

1

EAISETDRECPDCGGDVLEVGYMPSVTEFVTGWKCQDCDWADTDRD

46

EAISETDRECPDCGGDVLEVGYMPSVTEFVTGWKCQDCDWADTDRD

1

EAISETDRECPDCGGDVLEVGYMPSVTEFVTGWKCQDCDWADTDRD

46

84.8%

NZ_CP119804.1:

Lanthipeptides: P2T57_RS03940_lanthipeptide

1

EAISETDRECPDCGGDVLEVGYMPSVTEFVTGWKCQDCDWADTDRD

46

E+I +TDRECPDCG DVLEVGYMPSVTEFVTGWKCQ+CDW+DTDR+

1

ESIEDTDRECPDCGEDVLEVGYMPSVTEFVTGWKCQECDWSDTDRE

46

78.3%

NZ_CP096019.1:

Lanthipeptides: MW046_RS07480_lanthipeptide

1

EAISETDRECPDCGGDVLEVGYMPSVTEFVTGWKCQDCDWADTDRD

46

E+IS+TDRECPDCGG V+ VGYMPSV EFVTG+KCQDCDW TDR+

1

ESISDTDRECPDCGGPVVSVGYMPSVMEFVTGYKCQDCDWKATDRE

46

with 2 more sequence matches

15.2%

NZ_ML974127.1:

Lanthipeptides: EPL00_RS07380_lanthipeptide

9

ECPDCGGDVLEV

20

+CPDCGG + V

19

KCPDCGGALTFV

30

13.0%

NZ_CP096019.1:

Lanthipeptides: allorf_1444717_1444914_lanthipeptide

10

CPDCGGDVLE

19

CP+CGG +E

15

CPECGGYAIE

24

MIBiG 4.0 matches for EPL00_RS07765

8.7%

BGC0000582.4 (ADR72962.1):

Linaridin: cypemycin

24

PSVTEFV

30

P+V +FV

6

PTVAQFV

12

allorf_1546009_1546125

Leader:

MSDFETYTCENCGDEFKAQESANAA

Core:

DESYCSPKCQTAA

Core with dehydrations:

DEDhaYCysDhaPKCysQDhbAA

antiSMASH-DB 4.0 matches for allorf_1546009_1546125

100.0%

NZ_ML974127.1:

Lanthipeptides: allorf_1546009_1546125_lanthipeptide

1

DESYCSPKCQTAA

13

DESYCSPKCQTAA

1

DESYCSPKCQTAA

13

85.7%

NZ_CP096658.1:

Lanthipeptides: allorf_3178073_3178228_lanthipeptide

1

DESYCSPKCQTAA

13

+ESYCSPKCQTAA

2

EESYCSPKCQTAA

14

23.7%

NZ_CP119804.1:

Lanthipeptides: allorf_0774884_0775030_lanthipeptide

1

DESYCSPKCQTAA

13

+ YCSPKCQT A

26

ENGYCSPKCQTTA

38

with 24 more sequence matches

Only the first 10 are displayed here.

23.3%

NZ_CP086322.1and 1 other:

NZ_NDXL01000003.1 Lanthipeptides: B7024_RS31125_lanthipeptide

Lanthipeptides: K9S39_RS23570_lanthipeptide

3

SYCSPKCQTAA

13

S C+P C TAA

5

SLCTPGCVTAA

15

21.9%

NC_014479.1and 9 others:

NZ_CP026362.1 Lanthipeptides: BV11031_RS00400_lanthipeptideNZ_CP033052.1 Lanthipeptides: D9779_RS17315_lanthipeptideNZ_CP051464.1 Lanthipeptides: HC660_RS17030_lanthipeptideNZ_JALAKK010000002.1 Lanthipeptides: MOB09_RS02800_lanthipeptideNZ_JALAKO010000014.1 Lanthipeptides: MOB26_RS08535_lanthipeptideNZ_JALAOG010000003.1 Lanthipeptides: MOC96_RS02500_lanthipeptideNZ_JALAPG010000043.1 Lanthipeptides: MOC70_RS16815_lanthipeptideNZ_JALAQI010000009.1 Lanthipeptides: MOD13_RS06065_lanthipeptideNZ_NXEM01000027.1 Lanthipeptides: CPT06_RS15285_lanthipeptide

Lanthipeptides: BSUW23_RS16845_lanthipeptide

1

DESYCSPKCQTAA

13

ES C+P C T A

3

SESLCTPGCVTGA

15

20.8%

NZ_CP007699.2and 8 others:

NZ_CP048882.1 Lanthipeptides: G4Z16_RS06545_lanthipeptideNZ_CP048882.1 Lanthipeptides: G4Z16_RS06545_lanthipeptideNZ_FMHI01000015.1 Lanthipeptides: H180DRAFT_RS21560_lanthipeptideNZ_JADDUE010000020.1 Lanthipeptides: INP57_RS28495_lanthipeptideNZ_JAMTCQ010000009.1 Lanthipeptides: LY41_RS11610_lanthipeptideNZ_KB905819.1 Lanthipeptides: F603_RS34750_lanthipeptideNZ_LIVZ01000011.1 Lanthipeptides: AMK31_RS29125_lanthipeptideNZ_LIXJ01000007.1 Lanthipeptides: AMK22_RS13160_lanthipeptide

Lanthipeptides: T261_RS08380_lanthipeptide

3

SYCSPKCQT

11

SYC+P C +

5

SYCTPGCTS

13

20.7%

NZ_CP101621.1:

Lanthipeptides: NN913_RS16125_lanthipeptide

1

DESYCSPKCQTAA

13

+S C+P C T A

3

SKSLCTPGCITGA

15

20.0%

NZ_CP034587.1:

Lanthipeptides: EKH77_RS16870_lanthipeptide

3

SYCSPKCQTAA

13

S C+P C +AA

5

SLCTPGCPSAA

15

18.8%

NC_016047.1and 2 others:

NZ_KZ848487.1 Lanthipeptides: DSL71_RS15965_lanthipeptideNZ_MUXL01000003.1 Lanthipeptides: B0W20_RS12275_lanthipeptide

Lanthipeptides: GYO_RS39160_lanthipeptide

1

DESYCSPKCQTA

12

ES C+P C T

3

SESVCTPGCVTG

14

18.8%

NZ_CP021903.1and 20 others:

NZ_CP023409.1 Lanthipeptides: Bateq7PJ16_RS18530_lanthipeptideNZ_CP026036.1 Lanthipeptides: C2H93_RS15000_lanthipeptideNZ_CP028218.1 Lanthipeptides: C7M30_RS14555_lanthipeptideNZ_CP035167.1 Lanthipeptides: EQJ08_RS17140_lanthipeptideNZ_CP035226.1 Lanthipeptides: EQW70_RS18175_lanthipeptideNZ_CP045006.1 Lanthipeptides: F9B13_RS03875_lanthipeptideNZ_CP076083.1 Lanthipeptides: KFF76_RS16710_lanthipeptideNZ_CP079759.1 Lanthipeptides: KXZ66_RS17780_lanthipeptideNZ_CP080508.1 Lanthipeptides: K0V03_RS06525_lanthipeptideNZ_CP089148.1 Lanthipeptides: LRO88_RS19055_lanthipeptideNZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04985_lanthipeptideNZ_JALAVX010000009.1 Lanthipeptides: MOE40_RS09385_lanthipeptideNZ_JAMYDW010000007.1 Lanthipeptides: NHM07_RS16180_lanthipeptideNZ_JAQOXM010000001.1 Lanthipeptides: PO770_RS03875_lanthipeptideNZ_NJRD01000003.1 Lanthipeptides: CE053_RS07200_lanthipeptideNZ_NJRE01000008.1 Lanthipeptides: CE047_RS18435_lanthipeptideNZ_SORJ01000001.1 Lanthipeptides: BJ795_RS01490_lanthipeptideNZ_VFNF01000001.1 Lanthipeptides: FB592_RS01525_lanthipeptideNZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03850_lanthipeptideNZ_VLJL01000012.1 Lanthipeptides: L604_RS09425_lanthipeptide

Lanthipeptides: CD007_RS17065_lanthipeptide

1

DESYCSPKCQTAA

13

ES C+P C T

3

SESLCTPGCVTGV

15

18.8%

NZ_CP025079.1and 3 others:

NZ_CP047644.1 Lanthipeptides: GNE05_RS17275_lanthipeptideNZ_CP099859.1 Lanthipeptides: NIZ95_RS16280_lanthipeptideNZ_CP101621.1 Lanthipeptides: NN913_RS16115_lanthipeptide

Lanthipeptides: BVQ_RS17705_lanthipeptide

1

DESYCSPKCQTAA

13

ES C+P C T

3

SESVCTPGCVTGV

15

18.8%

NZ_CP059471.1and 3 others:

NZ_FNZW01000001.1 Lanthipeptides: BMZ61_RS02110_lanthipeptideNZ_FOYC01000001.1 Lanthipeptides: BMZ88_RS03370_lanthipeptideNZ_KE384124.1 Lanthipeptides: G597_RS0106700_lanthipeptide

Lanthipeptides: H1R75_RS06635_lanthipeptide

1

DESYCSPKCQTAA

13

+S C+P C+T A

3

SKSLCTPGCKTGA

15

18.2%

NZ_CP085954.1:

Lanthipeptides: LK411_RS13585_lanthipeptide

2

ESYCSPKCQTAA

13

+S C+P C T A

4

KSLCTPGCPTGA

15

MIBiG 4.0 matches for allorf_1546009_1546125

17.6%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

3

SYCSPKCQTAA

13

S C+P C+T A

5

SLCTPGCKTGA

15

allorf_1566942_1567100

Leader:

MARGRGAARCCAGRSTPSSRHRGCSRWGLLSRHGS

Core:

RSRCDSWSWCDSWRAVR

Core with dehydrations:

RDhaRCysDDhaWDhaWCysDDhaWRAVR

antiSMASH-DB 4.0 matches for allorf_1566942_1567100

100.0%

NZ_ML974127.1:

Lanthipeptides: allorf_1566942_1567100_lanthipeptide

1

RSRCDSWSWCDSWRAVR

17

RSRCDSWSWCDSWRAVR

1

RSRCDSWSWCDSWRAVR

17

30.4%

NC_012470.1and 5 others:

NZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS10335_lanthipeptideNZ_CP065058.1 Lanthipeptides: I2434_RS07250_lanthipeptideNZ_CP078012.1 Lanthipeptides: KV238_RS00510_lanthipeptideNZ_LS483328.1 Lanthipeptides: DQL47_RS07600_lanthipeptideNZ_LS483368.1 Lanthipeptides: DQM56_RS07295_lanthipeptide

Lanthipeptides: SZO_RS10195_lanthipeptide

1

RSRCDSWSWCDSWRAV

16

R S SWC +W A+

3

RFSTTSLSWCGNWSAI

18

allorf_1567150_1567224

Leader:

MSDYTKTRRALARPEVAAS

Core:

SSCEG

Core with dehydrations:

DhaDhaCysEG

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

(Thi)azol(in)e containing peptide predictions

No core peptides found.

Lanthipeptides

Azole RiPPs

Core peptide predictions

EPL00_RS07765 - Class II

Cleavage pHMM score: -5.60

RODEO score: 0

Monoisotopic mass: 5034.1 Da

Molecular weight: 5037.4 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 5055.4 Da N = 1; 5073.4 Da N = 2

allorf_1546009_1546125 - Class II

Cleavage pHMM score: -6.20

RODEO score: 0

Monoisotopic mass: 1347.6 Da

Molecular weight: 1348.4 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 1366.5 Da N = 1

allorf_1566942_1567100 - Class II

Cleavage pHMM score: -6.60

RODEO score: 0

Monoisotopic mass: 2083.0 Da

Molecular weight: 2084.3 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2102.3 Da N = 1; 2120.3 Da N = 2

allorf_1567150_1567224 - Class II

Cleavage pHMM score: -7.00

RODEO score: 0

Monoisotopic mass: 445.1 Da

Molecular weight: 445.4 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 463.5 Da N = 1

Core peptide predictions

No core peptides found.

NZ_ML974127.1 - Region 7 - terpene-precursor

Download region GenBank file

Download region SVG

Location: 1,573,391 - 1,585,202 nt. (total: 11,812 nt) Show pHMM detection rules used

Region on contig edge.

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

EPL00_RS07905: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

Ligases: synthetase

EPL00_RS07935: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.46	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.43	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000677.5	0.37	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0001972.4	0.37	other (other)	toxoflavin, fervenulin	Streptomyces hiroshimensis
BGC0002309.2	0.36	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000639.3	0.34	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0001911.3	0.34	terpene	raimonol	Streptomyces anulatus
BGC0000642.3	0.33	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0001910.4	0.32	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.46	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.43	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000677.5	0.37	terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0001972.4	0.37	other (other)	toxoflavin, fervenulin	Streptomyces hiroshimensis
BGC0002309.2	0.36	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000639.3	0.34	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0001911.3	0.34	terpene	raimonol	Streptomyces anulatus
BGC0000642.3	0.33	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0001910.4	0.32	terpene	cyslabdan A, cyslabdan B, cyslabdan C	Streptomyces cyslabdanicus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

EPL00_RS07935: PT_FPPS_like

Domain 1 (40 - 351): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Terpene

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

NZ_ML974128.1 - Region 1 - terpene

Download region GenBank file

Download region SVG

Location: 100,544 - 120,885 nt. (total: 20,342 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Isomerases: isomerase

EPL00_RS08555: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: synthase

EPL00_RS08550: carbamoyl phosphate synthase small subunit

smcogs: SMCOG1249: carbamoyl phosphate synthase small subunit

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001962.3	0.40	PKS	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0002031.3	0.39	other (other)	kitasetaline	Kitasatospora setae KM-6054
BGC0001778.5	0.32	other (other)	showdomycin	Streptomyces showdoensis
BGC0000514.5	0.32	ribosomal	gallidermin	Staphylococcus gallinarum
BGC0000922.5	0.30	PKS	2-heptyl-3-hydroxy-4-quinolone, 2,4-Quinolinediol, 2-heptylquinolin-4(1H)-one	Pseudomonas aeruginosa PAO1
BGC0002324.3	0.29	NRPS, PKS	myxochelin B, myxochelin N, myxochelin O, myxochelin P, myxochelin Q, myxochelin A	Archangium violaceum
BGC0001529.5	0.29	other (other)	benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K	Streptomyces sp. RI18
BGC0002668.2	0.29	ribosomal	cesin A	Clostridium estertheticum
BGC0002439.3	0.29	other (other)	diastaphenazine, izumiphenazine C	Streptomyces diastaticus
BGC0002492.3	0.28	NRPS	myxochelin B, myxochelin A	Myxococcus xanthus DK 1622

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001962.3	0.40	PKS	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0002031.3	0.39	other (other)	kitasetaline	Kitasatospora setae KM-6054
BGC0001778.5	0.32	other (other)	showdomycin	Streptomyces showdoensis
BGC0000514.5	0.32	ribosomal	gallidermin	Staphylococcus gallinarum
BGC0000922.5	0.30	PKS	2-heptyl-3-hydroxy-4-quinolone, 2,4-Quinolinediol, 2-heptylquinolin-4(1H)-one	Pseudomonas aeruginosa PAO1
BGC0002324.3	0.29	NRPS, PKS	myxochelin B, myxochelin N, myxochelin O, myxochelin P, myxochelin Q, myxochelin A	Archangium violaceum
BGC0001529.5	0.29	other (other)	benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K	Streptomyces sp. RI18
BGC0002668.2	0.29	ribosomal	cesin A	Clostridium estertheticum
BGC0002439.3	0.29	other (other)	diastaphenazine, izumiphenazine C	Streptomyces diastaticus
BGC0002492.3	0.28	NRPS	myxochelin B, myxochelin A	Myxococcus xanthus DK 1622

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
tetraterpene	C40 carotenoid		C40	unknown	unknown

Genes with terpene domains:

EPL00_RS08610: Lycopene_cycl

Domain 1 (12 - 91): Lycopene cyclase

Reactions:: C40_carotenoid → C40_carotenoid

Terpene

Glossary

No acronyms to display

NZ_ML974128.1 - Region 2 - RiPP-like

Download region GenBank file

Download region SVG

Location: 355,327 - 367,147 nt. (total: 11,821 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: phosphatase

EPL00_RS09920: inositol monophosphatase

smcogs: SMCOG1207: inositol monophosphatase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002584.2	0.45	ribosomal	azolemycin B, azolemycin A, azolemycin D, azolemycin C	Streptomyces sp. FXJ1.264
BGC0000878.5	0.39	other (other)	puromycin	Streptomyces alboniger
BGC0000249.5	0.29	PKS	nogalamycin	Streptomyces nogalater
BGC0000716.5	0.28	saccharide	spectinomycin	Streptomyces netropsis
BGC0002652.2	0.28	other (other), saccharide	cytosaminomycin F, cytosaminomycin G, streptcytosine P, plicacetin, 40551-F, 12F-plicacetin, streptcytosine D, streptcytosine E	Streptomyces sp. SHP22-7
BGC0000715.5	0.28	saccharide	actinospectacin	Streptomyces spectabilis
BGC0000873.3	0.25	other (other)	A-201A	Saccharothrix mutabilis subsp. capreolus
BGC0000953.5	0.25	saccharide	amicetin	Streptomyces vinaceusdrappus
BGC0002288.2	0.24	NRPS	ashimide A, ashimide B	Streptomyces sp. NA03103
BGC0001138.5	0.24	other (nucleoside)	a201a	Marinactinospora thermotolerans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002584.2	0.45	ribosomal	azolemycin B, azolemycin A, azolemycin D, azolemycin C	Streptomyces sp. FXJ1.264
BGC0000878.5	0.39	other (other)	puromycin	Streptomyces alboniger
BGC0000249.5	0.29	PKS	nogalamycin	Streptomyces nogalater
BGC0000716.5	0.28	saccharide	spectinomycin	Streptomyces netropsis
BGC0002652.2	0.28	other (other), saccharide	cytosaminomycin F, cytosaminomycin G, streptcytosine P, plicacetin, 40551-F, 12F-plicacetin, streptcytosine D, streptcytosine E	Streptomyces sp. SHP22-7
BGC0000715.5	0.28	saccharide	actinospectacin	Streptomyces spectabilis
BGC0000873.3	0.25	other (other)	A-201A	Saccharothrix mutabilis subsp. capreolus
BGC0000953.5	0.25	saccharide	amicetin	Streptomyces vinaceusdrappus
BGC0002288.2	0.24	NRPS	ashimide A, ashimide B	Streptomyces sp. NA03103
BGC0001138.5	0.24	other (nucleoside)	a201a	Marinactinospora thermotolerans

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

NZ_SBIS02000007.1 - Region 1 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 22,163 - 45,384 nt. (total: 23,222 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: methyltransferase

EPL00_RS13675: methyltransferase

smcogs: SMCOG1248: methyltransferase

Lyases: cyclase

EPL00_RS13700: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002703.2	0.50	ribosomal	archalan α	Halorussus salinus
BGC0000525.5	0.50	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0002704.2	0.47	ribosomal	archalan β	Halorussus salinus
BGC0002698.2	0.43	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000517.4	0.41	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0002699.2	0.41	ribosomal	nostolysamide A, nostolysamide B	Nostoc punctiforme PCC 73102
BGC0000486.4	0.40	ribosomal	butyrivibriocin AR10	Butyrivibrio fibrisolvens
BGC0001222.3	0.39	ribosomal	acidocin B	Lactobacillus acidophilus
BGC0000491.5	0.39	ribosomal	gassericin A	Lactobacillus gasseri
BGC0001887.3	0.38	ribosomal	huazacin	Bacillus thuringiensis serovar huazhongensis BGSC 4BD1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002703.2	0.50	ribosomal	archalan α	Halorussus salinus
BGC0000525.5	0.50	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0002704.2	0.47	ribosomal	archalan β	Halorussus salinus
BGC0002698.2	0.43	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000517.4	0.41	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0002699.2	0.41	ribosomal	nostolysamide A, nostolysamide B	Nostoc punctiforme PCC 73102
BGC0000486.4	0.40	ribosomal	butyrivibriocin AR10	Butyrivibrio fibrisolvens
BGC0001222.3	0.39	ribosomal	acidocin B	Lactobacillus acidophilus
BGC0000491.5	0.39	ribosomal	gassericin A	Lactobacillus gasseri
BGC0001887.3	0.38	ribosomal	huazacin	Bacillus thuringiensis serovar huazhongensis BGSC 4BD1

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for EPL00_RS13700

EPL00_RS24065

Leader:

MSSDSLKDQIEAAYEQDERPVEAGTEQAG

Core:

QMTVAFCGGHYTNLE

Core with dehydrations:

QMDhbVAFCysGGHYDhbNLE

antiSMASH-DB 4.0 matches for EPL00_RS24065

100.0%

NZ_SBIS02000007.1:

Lanthipeptides: EPL00_RS24065_lanthipeptide

1

QMTVAFCGGHYTNLE

15

QMTVAFCGGHYTNLE

1

QMTVAFCGGHYTNLE

15

25.0%

NZ_CP019893.1:

Lanthipeptides: B1756_RS19455_lanthipeptide

1

QMTVAFC

7

MT+AFC

6

HMTIAFC

12

25.0%

NZ_JAKRKC020000001.1:

Lanthipeptides: MF672_RS25655_lanthipeptide

1

QMTVAFCGGH

10

+TVA CG H

4

SLTVATCGSH

13

EPL00_RS13710

Leader:

MKNEIRARRDAEGISQADLAAA

Core:

VGVTRQTINAIERERYDPSIELAFKLADHFDCRIEDLFDPELNGVGEGG

Core with dehydrations:

VGVDhbRQDhbINAIERERYDPDhaIELAFKLADHFDCysRIEDLFDPELNGVGEGG

antiSMASH-DB 4.0 matches for EPL00_RS13710

100.0%

NZ_SBIS02000007.1:

Lanthipeptides: EPL00_RS13710_lanthipeptide

1

VGVTRQTINAIERERYDPSIELAFKLADHFDCRIEDLFDPELNGVGEGG

49

VGVTRQTINAIERERYDPSIELAFKLADHFDCRIEDLFDPELNGVGEGG

1

VGVTRQTINAIERERYDPSIELAFKLADHFDCRIEDLFDPELNGVGEGG

49

40.4%

NZ_NTSR01000029.1and 1 other:

NZ_NTSR01000029.1 Lanthipeptides: CN358_RS25150_lanthipeptide

Lanthipeptides: CN358_RS25150_lanthipeptide

2

GVTRQTINAIERERYDPSIELAFKLADHFDCRIEDLFDP

40

V+RQTINAIE ++YDPS++LAF ++ + ++EDLF P

7

NVSRQTINAIENKKYDPSLQLAFDISKQLEIKMEDLFLP

45

38.8%

NZ_QPJT01000003.1:

Lanthipeptides: DFR58_RS03990_lanthipeptide

4

TRQTINAIERERYDPSIELAFKLADHFDCRIEDLFD

39

TRQTI ++E E+Y S+ LA+K+A +F+ IED+FD

1

TRQTITSLECEKYTASLILAYKIAKYFETTIEDIFD

36

with 8 more sequence matches

34.7%

NZ_KN125582.1:

Lanthipeptides: DJ91_RS27555_lanthipeptide

4

TRQTINAIERERYDPSIELAFKLADHFDCRIEDLFD

39

TRQTI+A+E+ +Y PS+ELAFK+ + I+++F+

1

TRQTISAVEKNKYSPSLELAFKICKVLEKSIDEVFE

36

33.3%

NZ_QICS01000003.1:

Lanthipeptides: C8E03_RS08720_lanthipeptide

1

VGVTRQTINAIERERYDPSIELAFKLADHFDCRIEDLF

38

V V+ +TI +IE E+Y PS+ LA+++A+ F +EDL+

3

VNVSSRTIISIENEKYKPSLILAYRIAEIFKVSMEDLY

40

32.7%

NZ_NVMQ01000017.1:

Lanthipeptides: CON32_RS17800_lanthipeptide

4

TRQTINAIERERYDPSIELAFKLADHFDCRIEDLFD

39

TRQTI+A+E+ +Y PS++LAF++ F +E++F+

1

TRQTISALEKNKYTPSLDLAFRICKIFGRTVEEVFE

36

26.5%

NZ_EQ973330.1and 2 others:

NZ_LR134504.1 Lanthipeptides: EL293_RS07235_lanthipeptideNZ_LR134504.1 Lanthipeptides: EL293_RS07235_lanthipeptide

Lanthipeptides: CORMATOL_RS10555_lanthipeptide

1

VGVTRQTINAIERERYDP-SIELAFKLADHFDCRIEDLFDPE

41

VGVT ++ ++ R L D DC+ DLF E

5

VGVTVANLSVLKNNRAKAVRFTTLVALCDALDCQPGDLFTAE

46

24.5%

NZ_QUCI01000001.1:

Lanthipeptides: DW648_RS00980_lanthipeptide

4

TRQTINAIERERYDPSIELAFKLADHFDCRIEDLF

38

+R T+++IE +++P+ +LA L D + E+LF

1

SRNTVSSIETGQFNPTAKLALVLCIALDKKFEELF

35

18.4%

NZ_QNRN01000010.1:

Lanthipeptides: DET63_RS17600_lanthipeptide

1

VGVTRQTINAIERERYDPSIELAFKLADHFDCRIEDLF

38

VG++ T+ E + P + KLA+ + ++ +F

1

VGISVSTLQMYENGQRIPRDNIKIKLANFYGVTVQIIF

38

16.3%

NZ_CP034248.1:

Lanthipeptides: EIM92_RS23730_lanthipeptide

9

NAIERERYDPSIELAFKLADHFDCRIEDLFDPE

41

NA+ +ER P + + K+ H + + E

11

NALSQERISPHVAIVNKVISHMQRTVVRILATE

43

12.2%

NZ_BLIS01000009.1and 5 others:

NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04860_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02665_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02665_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01890_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01890_lanthipeptide

Lanthipeptides: GVO03_RS04860_lanthipeptide

17

DPSIELAFKLADHFDCRIEDLFD

39

+ + ++ K+ DC+IED+ +

13

NVTTDILLKICIALDCKIEDIIE

35

MIBiG 4.0 matches for EPL00_RS13710

8.2%

BGC0000503.5 (cinA):

Lanthipeptide: cinnamycin

32

CRIEDLFDP

40

CR F P

1

CRQSCSFGP

9

allorf_035508_035597

Leader:

MSEIGRLRISAWG

Core:

SHLRCCRSRLTLRYYL

Core with dehydrations:

DhaHLRCysCysRDhaRLDhbLRYYL

antiSMASH-DB 4.0 matches for allorf_035508_035597

100.0%

NZ_SBIS02000007.1:

Lanthipeptides: allorf_035508_035597_lanthipeptide

1

SHLRCCRSRLTLRYYL

16

SHLRCCRSRLTLRYYL

1

SHLRCCRSRLTLRYYL

16

23.3%

NZ_CP023465.1and 1 other:

NZ_CP094357.1 Lanthipeptides: allorf_0702195_0702320_lanthipeptide

Lanthipeptides: allorf_0701083_0701208_lanthipeptide

1

SHLRCCRSRLTLRYYL

16

+HLRC RS + + Y

1

AHLRCARSAMCVNCYF

16

20.0%

NZ_CP011130.1and 1 other:

NZ_KQ061218.1 Lanthipeptides: allorf_233227_233415_lanthipeptide

Lanthipeptides: allorf_0735524_0735712_lanthipeptide

1

SHLRCCRSRLTLRYYL

16

+H+RC RS + + Y

1

AHVRCARSAMCVNCYF

16

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

EPL00_RS24065 - Class II

Cleavage pHMM score: -2.20

RODEO score: 0

Monoisotopic mass: 1633.7 Da

Molecular weight: 1634.8 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1652.8 Da N = 1

EPL00_RS13710 - Class II

Cleavage pHMM score: -3.50

RODEO score: 0

Monoisotopic mass: 5449.7 Da

Molecular weight: 5453.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 5471.0 Da N = 1; 5489.0 Da N = 2

allorf_035508_035597 - Class II

Cleavage pHMM score: -7.30

RODEO score: 0

Monoisotopic mass: 1985.1 Da

Molecular weight: 1986.4 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2004.4 Da N = 1

NZ_SBIS02000007.1 - Region 2 - azole-containing-RiPP

Download region GenBank file

Download region SVG

Location: 354,479 - 378,801 nt. (total: 24,323 nt) Show pHMM detection rules used

azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Azole RiPPs

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001174.4	0.49	ribosomal	corynazolicin	Corynebacterium urealyticum DSM 7111
BGC0002013.4	0.47	ribosomal	curacozole	Streptomyces curacoi
BGC0000916.5	0.44	other (other)	molybdenum cofactor	Staphylococcus carnosus
BGC0000565.5	0.41	ribosomal	goadsporin	Streptomyces sp. TP-A0584
BGC0000592.5	0.41	ribosomal	microviridin B	Microcystis aeruginosa NIES-298
BGC0002049.3	0.40	ribosomal	microviridin N9, microviridin N8, microviridin N7, microviridin N6, microviridin N5, microviridin N4, microviridin N3	Nostoc punctiforme PCC 73102
BGC0000594.5	0.40	ribosomal	microviridin K	Planktothrix agardhii NIVA-CYA 126/8
BGC0002656.2	0.37	PKS	oryzanaphthopyran A, oryzanaphthopyran B, oryzanaphthopyran C, oryzanthrone A, oryzanthrone B, chlororyzanthrone A, chlororyzanthrone B	Streptacidiphilus oryzae TH49
BGC0001748.4	0.37	NRPS, PKS	pseudospumigin A, pseudospumigin B, pseudospumigin C, pseudospumigin D, pseudospumigin E, pseudospumigin F	Nostoc sp. CENA543
BGC0001843.2	0.36	NRPS	tridecaptin M	Paenibacillus sp. M-152

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001174.4	0.49	ribosomal	corynazolicin	Corynebacterium urealyticum DSM 7111
BGC0002013.4	0.47	ribosomal	curacozole	Streptomyces curacoi
BGC0000916.5	0.44	other (other)	molybdenum cofactor	Staphylococcus carnosus
BGC0000565.5	0.41	ribosomal	goadsporin	Streptomyces sp. TP-A0584
BGC0000592.5	0.41	ribosomal	microviridin B	Microcystis aeruginosa NIES-298
BGC0002049.3	0.40	ribosomal	microviridin N9, microviridin N8, microviridin N7, microviridin N6, microviridin N5, microviridin N4, microviridin N3	Nostoc punctiforme PCC 73102
BGC0000594.5	0.40	ribosomal	microviridin K	Planktothrix agardhii NIVA-CYA 126/8
BGC0002656.2	0.37	PKS	oryzanaphthopyran A, oryzanaphthopyran B, oryzanaphthopyran C, oryzanthrone A, oryzanthrone B, chlororyzanthrone A, chlororyzanthrone B	Streptacidiphilus oryzae TH49
BGC0001748.4	0.37	NRPS, PKS	pseudospumigin A, pseudospumigin B, pseudospumigin C, pseudospumigin D, pseudospumigin E, pseudospumigin F	Nostoc sp. CENA543
BGC0001843.2	0.36	NRPS	tridecaptin M	Paenibacillus sp. M-152

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

(Thi)azol(in)e containing peptide predictions

No core peptides found.

Azole RiPPs

Core peptide predictions

No core peptides found.

NZ_ML974129.1 - Region 1 - terpene

Download region GenBank file

Download region SVG

Location: 208,496 - 229,578 nt. (total: 21,083 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

EPL00_RS12970: 3-hydroxybutyryl-CoA dehydrogenase

smcogs: SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase

EPL00_RS12995: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Hydrolases: hydrolase

EPL00_RS12960: isochorismatase

smcogs: SMCOG1027: isochorismatase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000706.3	0.45	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0002284.3	0.42	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0001778.5	0.40	other (other)	showdomycin	Streptomyces showdoensis
BGC0000207.5	0.37	PKS	chartreusin	Streptomyces chartreusis
BGC0001464.3	0.35	other (other)	tetrabromopyrrole	Pseudoalteromonas sp. PS5
BGC0001463.4	0.35	other (other)	2,3,4,5-tetrabromopyrrole	Pseudoalteromonas piscicida
BGC0002147.2	0.33	NRPS	bohemamine A, bohemamine B, bohemamine C	Streptomyces sp. CB02009
BGC0000147.5	0.33	PKS	soraphen A	Sorangium cellulosum
BGC0002091.3	0.32	NRPS	holomycin	Yersinia ruckeri ATCC 29473
BGC0000679.5	0.32	terpene	diazepinomicin	Micromonospora sp. M42

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000706.3	0.45	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0002284.3	0.42	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0001778.5	0.40	other (other)	showdomycin	Streptomyces showdoensis
BGC0000207.5	0.37	PKS	chartreusin	Streptomyces chartreusis
BGC0001464.3	0.35	other (other)	tetrabromopyrrole	Pseudoalteromonas sp. PS5
BGC0001463.4	0.35	other (other)	2,3,4,5-tetrabromopyrrole	Pseudoalteromonas piscicida
BGC0002147.2	0.33	NRPS	bohemamine A, bohemamine B, bohemamine C	Streptomyces sp. CB02009
BGC0000147.5	0.33	PKS	soraphen A	Sorangium cellulosum
BGC0002091.3	0.32	NRPS	holomycin	Yersinia ruckeri ATCC 29473
BGC0000679.5	0.32	terpene	diazepinomicin	Micromonospora sp. M42

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene		squalene	C30	acyclic	none
triterpene	C30 carotenoid	diapophytoene	C30	acyclic	none
triterpene		PSPP	C30	acyclic	PP
tetraterpene	C40 carotenoid	phytoene	C40	acyclic	none
triterpene		hydroxysqualene	C30	acyclic	OH

Genes with terpene domains:

EPL00_RS12980: PT_phytoene_like

Domain 1 (25 - 293): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → squalene; FPP → diapophytoene; FPP → PSPP; GGPP → phytoene; PSPP → hydroxysqualene

Terpene

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
PP	Diphosphate
PSPP	Presqualene diphosphate

NZ_SBIS02000011.1 - Region 1 - lanthipeptide-class-ii,terpene-precursor,triceptide

Download region GenBank file

Download region SVG

Location: 167,395 - 233,689 nt. (total: 66,295 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)
triceptide: ((cds(PF04055 and (TIGR04085 or SPASM)) and triceptide_precursor) or triceptide_rSAM)
terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

Terpene

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

EPL00_RS20245: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: aminotransferase methyltransferase

EPL00_RS20345: methyltransferase

smcogs: SMCOG1089: methyltransferase

EPL00_RS20525: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Hydrolases: protease

EPL00_RS20405: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase

EPL00_RS20295: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

EPL00_RS20485: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Ligases: synthetase

EPL00_RS20420: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002704.2	1.16	ribosomal	archalan β	Halorussus salinus
BGC0000601.4	0.39	ribosomal	sporulation killing factor	Bacillus subtilis subsp. subtilis str. 168
BGC0002162.3	0.36	terpene	sesterfisherol, sesterfisheric acid, compound 6, compound 7a, compound 5, compound 8	Aspergillus fischeri NRRL 181
BGC0002736.2	0.36	terpene	preaspterpenacid I	Aspergillus terreus NIH2624
BGC0002703.2	0.34	ribosomal	archalan α	Halorussus salinus
BGC0000905.5	0.32	other (other)	heme D1	Heliobacillus mobilis
BGC0000906.3	0.32	other (other)	heme D1	Heliophilum fasciatum
BGC0000554.4	0.30	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000640.3	0.28	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0001660.3	0.26	ribosomal	mathermycin	Marinactinospora thermotolerans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002704.2	1.00	ribosomal	archalan β	Halorussus salinus
BGC0002703.2	0.51	ribosomal	archalan α	Halorussus salinus
BGC0002162.3	0.50	terpene	sesterfisherol, sesterfisheric acid, compound 6, compound 7a, compound 5, compound 8	Aspergillus fischeri NRRL 181
BGC0001579.4	0.50	ribosomal	duramycin	Streptomyces cinnamoneus
BGC0002736.2	0.50	terpene	preaspterpenacid I	Aspergillus terreus NIH2624
BGC0000601.4	0.48	ribosomal	sporulation killing factor	Bacillus subtilis subsp. subtilis str. 168
BGC0000503.5	0.48	ribosomal	cinnamycin	Streptomyces cinnamoneus
BGC0000563.4	0.48	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0000554.4	0.47	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0001226.4	0.47	ribosomal	streptocollin	Streptomyces collinus Tu 365

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for EPL00_RS20295

allorf_171921_172073

Leader:

MNATRNRRRDAPRESRVCGA

Core:

GRYGARCCGGAVVIVVGGNEHRPTSSQASE

Core with dehydrations:

GRYGARCysCysGGAVVIVVGGNEHRPDhbDhaDhaQADhaE

antiSMASH-DB 4.0 matches for allorf_171921_172073

100.0%

NZ_SBIS02000011.1:

Lanthipeptides: allorf_171921_172073_lanthipeptide

1

GRYGARCCGGAVVIVVGGNEHRPTSSQASE

30

GRYGARCCGGAVVIVVGGNEHRPTSSQASE

1

GRYGARCCGGAVVIVVGGNEHRPTSSQASE

30

23.3%

NZ_SNWQ01000001.1:

Lanthipeptides: EV643_RS00390_lanthipeptide

9

GGAVVIVVGGNEHRPTS

25

GG+ + V+G HRP++

3

GGSTLTVLGCGSHRPSN

19

20.0%

NZ_JACDUR010000003.1and 1 other:

NZ_JACDUR010000003.1 Lanthipeptides: HNR30_RS17930_lanthipeptide

Lanthipeptides: HNR30_RS17930_lanthipeptide

9

GGAVVIVVGGNEHRPTS

25

GG+ + V+G N + P++

4

GGSTLTVLGCNSYTPSN

20

with 4 more sequence matches

15.8%

NZ_CP073819.1:

Lanthipeptides: allorf_0065507_0065713_lanthipeptide

5

ARCCGGAVVIVVGG

18

+ CCGG+++ +GG

24

SNCCGGSLICSLGG

37

15.8%

NZ_CP081833.1and 1 other:

NZ_CP097053.1 Lanthipeptides: M2904_RS00460_lanthipeptide

Lanthipeptides: K5X77_RS00035_lanthipeptide

5

ARCCGGAVVIVVGG

18

+ CCGG+++ +GG

24

SNCCGGSIICSLGG

37

15.8%

NZ_GG692670.1:

Lanthipeptides: EFKG_RS0103895_lanthipeptide

5

ARCCGGAVVIVVGG

18

+ CCGG+++ +GG

24

SNCCGGSLMCSLGG

37

10.9%

NZ_CP069338.1:

Lanthipeptides: allorf_07271223_07271444_lanthipeptide

19

NEHRPTSSQA

28

+EHRPTS ++

12

DEHRPTSPES

21

allorf_175166_175240

Leader:

MAILGG

Core:

VCSSKGLTFYSQRRGIGA

Core with dehydrations:

VCysDhaDhaKGLDhbFYDhaQRRGIGA

antiSMASH-DB 4.0 matches for allorf_175166_175240

100.0%

NZ_SBIS02000011.1:

Lanthipeptides: allorf_175166_175240_lanthipeptide

1

VCSSKGLTFYSQRRGIGA

18

VCSSKGLTFYSQRRGIGA

1

VCSSKGLTFYSQRRGIGA

18

Lanthipeptide(s) for EPL00_RS20485

allorf_226672_226833

Leader:

MGWNAEFRATNGG

Core:

CVSTVGFPPPVSSGVVLSQHVRNLHKNIPSETSSGHETSR

Core with dehydrations:

CysVDhaDhbVGFPPPVDhaDhaGVVLDhaQHVRNLHKNIPDhaEDhbDhaDhaGHEDhbDhaR

antiSMASH-DB 4.0 matches for allorf_226672_226833

100.0%

NZ_SBIS02000011.1:

Lanthipeptides: allorf_226672_226833_lanthipeptide

1

CVSTVGFPPPVSSGVVLSQHVRNLHKNIPSETSSGHETSR

40

CVSTVGFPPPVSSGVVLSQHVRNLHKNIPSETSSGHETSR

1

CVSTVGFPPPVSSGVVLSQHVRNLHKNIPSETSSGHETSR

40

22.5%

NZ_CP113262.1:

Lanthipeptides: allorf_2442087_2442260_lanthipeptide

5

VGFPPPVSSGVVLSQHVRNLHK

26

+G P SSGVVL + L +

14

LGQPSGCSSGVVLERAGERLRR

35

18.6%

NZ_CP030771.1:

Lanthipeptides: allorf_09785478_09785648_lanthipeptide

11

VSSGVVLSQHVRNLHKNIPS

30

V SG+VL+ H R + P+

11

VGSGIVLNDHFRKCWVSAPT

30

with 3 more sequence matches

13.0%

NZ_BJTV01000007.1:

Lanthipeptides: allorf_023321_023548_lanthipeptide

16

VLSQHVRNLHK

26

VLS VR+LH+

10

VLSCWVRDLHR

20

12.5%

NZ_FOGM01000011.1:

Lanthipeptides: allorf_00061_00258_lanthipeptide

7

FPPPVSSGVVLSQHVR

22

FPPP + +L H++

22

FPPPSRTTAILVYHLK

37

9.7%

NZ_CP102415.1:

Lanthipeptides: NQK81_RS00170_lanthipeptide

2

VSTVGFPPPVSSGV

15

ST+ F P +GV

2

ASTIAFAQPAGAGV

15

allorf_228609_228767

Leader:

MIPAASLSADQPVAVALPTTAMTLETIIFP

Core:

ISIAAVGTNLDEGIQKSCKFVE

Core with dehydrations:

IDhaIAAVGDhbNLDEGIQKDhaCysKFVE

antiSMASH-DB 4.0 matches for allorf_228609_228767

100.0%

NZ_SBIS02000011.1:

Lanthipeptides: allorf_228609_228767_lanthipeptide

1

ISIAAVGTNLDEGIQKSCKFVE

22

ISIAAVGTNLDEGIQKSCKFVE

1

ISIAAVGTNLDEGIQKSCKFVE

22

10.4%

NZ_KB905395.1and 1 other:

NZ_KB905395.1 Lanthipeptides: allorf_13012_13248_lanthipeptide

Lanthipeptides: allorf_13012_13248_lanthipeptide

1

ISIAAVGTNLDEGIQKSCK

19

+ +A +G N +G +C+

18

VPLAKLGCNTSDGCGHTCQ

36

allorf_228797_229003

Leader:

MVSNVTLGPLGMGVLAGA

Core:

EMIRTGLLSSNLPVATVGVIICGSSLVLGYAVARPRQNKPNPDKGENRTG

Core with dehydrations:

EMIRDhbGLLDhaDhaNLPVADhbVGVIICysGDhaDhaLVLGYAVARPRQNKPNPDKGENRDhbG

antiSMASH-DB 4.0 matches for allorf_228797_229003

100.0%

NZ_SBIS02000011.1:

Lanthipeptides: allorf_228797_229003_lanthipeptide

1

EMIRTGLLSSNLPVATVGVIICGSSLVLGYAVARPRQNKPNPDKGENRTG

50

EMIRTGLLSSNLPVATVGVIICGSSLVLGYAVARPRQNKPNPDKGENRTG

1

EMIRTGLLSSNLPVATVGVIICGSSLVLGYAVARPRQNKPNPDKGENRTG

50

20.0%

NZ_ADVG01000001.1:

Lanthipeptides: allorf_1943256_1943423_lanthipeptide

19

VIICGSSLVLGYAVARPRQN

38

V++C +SL G ARPRQ+

7

VVLC-ASLPHGDLQARPRQD

25

18.0%

NZ_JANCLX010000003.1and 1 other:

NZ_JANCLX010000003.1 Lanthipeptides: NMK44_RS06265_lanthipeptide

Lanthipeptides: NMK44_RS06265_lanthipeptide

12

LPVATVGVIICGSSLVLGYAV

32

LP A ++C SSL+ G A+

1

LPDAAAATVLCASSLLCGSAL

21

with 1 more sequence matches

12.0%

NZ_CP026029.1:

Lassopeptides: C2I18_RS15915_lassopeptide

29

GYAVARPRQNKPN

41

G+A+A QN P+

3

GFAIADSFQNDPD

15

allorf_228993_229076

Leader:

METIVFS

Core:

SRHEGNYPPCALIVGGLAYR

Core with dehydrations:

DhaRHEGNYPPCysALIVGGLAYR

antiSMASH-DB 4.0 matches for allorf_228993_229076

100.0%

NZ_SBIS02000011.1:

Lanthipeptides: allorf_228993_229076_lanthipeptide

1

SRHEGNYPPCALIVGGLAYR

20

SRHEGNYPPCALIVGGLAYR

1

SRHEGNYPPCALIVGGLAYR

20

27.3%

NZ_BMNG01000001.1and 1 other:

NZ_CP048641.1 Lassopeptides: G3H79_RS13380_lassopeptide

Lassopeptides: IEY91_RS02775_lassopeptide

1

SRHEGNYPPCALIVG

15

+R+EG +PP +G

6

ARYEGGFPPYEWYLG

20

27.3%

NZ_CP040916.1:

Lassopeptides: FH965_RS40555_lassopeptide

1

SRHEGNYPPCALIVG

15

S +EG +PP +G

6

SYYEGGFPPYEWYLG

20

with 1 more sequence matches

22.7%

NZ_BNBL01000011.1:

Lassopeptides: IE295_RS25550_lassopeptide

1

SRHEGNYPPCALIVG

15

+++EG +PP +G

6

AQYEGGFPPYEWYLG

20

allorf_232870_232962

Leader:

MRRAFWRRTRNRFETFGRGYHYG

Core:

SHEVVCA

Core with dehydrations:

DhaHEVVCysA

antiSMASH-DB 4.0 matches for allorf_232870_232962

100.0%

NZ_SBIS02000011.1:

Lanthipeptides: allorf_232870_232962_lanthipeptide

1

SHEVVCA

7

SHEVVCA

1

SHEVVCA

7

allorf_232888_233061

Leader:

MGTVVVPTAEGLEPITGS

Core:

PPEGSAHPSHYLCVLASGQLVAETVGRSNFDGKVGESGA

Core with dehydrations:

PPEGDhaAHPDhaHYLCysVLADhaGQLVAEDhbVGRDhaNFDGKVGEDhaGA

antiSMASH-DB 4.0 matches for allorf_232888_233061

100.0%

NZ_SBIS02000011.1:

Lanthipeptides: allorf_232888_233061_lanthipeptide

1

PPEGSAHPSHYLCVLASGQLVAETVGRSNFDGKVGESGA

39

PPEGSAHPSHYLCVLASGQLVAETVGRSNFDGKVGESGA

1

PPEGSAHPSHYLCVLASGQLVAETVGRSNFDGKVGESGA

39

23.1%

NZ_MCIF01000002.1:

Lanthipeptides: allorf_2097064_2097252_lanthipeptide

1

PPEGSAHPSHY--LCVLA

16

PP +AHPS LC+L+

11

PPPSTAHPSSISALCLLS

28

15.4%

NZ_KV917376.1:

Lassopeptides: BK582_RS26540_lassopeptide

27

RSNFDGKVGESGA

39

+NFDGK+ ++ A

3

NANFDGKINKACA

15

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

EPL00_RS20420: PT_FPPS_like

Domain 1 (28 - 256): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Lanthipeptides

Terpene

Core peptide predictions

allorf_171921_172073 - Class II

Cleavage pHMM score: -4.80

RODEO score: 0

Monoisotopic mass: 2944.4 Da

Molecular weight: 2946.2 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2964.2 Da N = 1; 2982.3 Da N = 2

allorf_175166_175240 - Class II

Cleavage pHMM score: -6.40

RODEO score: 0

Monoisotopic mass: 1857.0 Da

Molecular weight: 1858.1 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1876.1 Da N = 1; 1894.2 Da N = 2; 1912.2 Da N = 3

allorf_226672_226833 - Class II

Cleavage pHMM score: -3.90

RODEO score: 0

Monoisotopic mass: 4028.1 Da

Molecular weight: 4030.4 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 4048.5 Da N = 1; 4066.5 Da N = 2; 4084.5 Da N = 3; 4102.5 Da N = 4; 4120.5 Da N = 5; 4138.6 Da N = 6; 4156.6 Da N = 7; 4174.6 Da N = 8; 4192.6 Da N = 9; 4210.6 Da N = 10

allorf_228609_228767 - Class II

Cleavage pHMM score: -6.60

RODEO score: 0

Monoisotopic mass: 2267.2 Da

Molecular weight: 2268.6 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2286.6 Da N = 1; 2304.6 Da N = 2

allorf_228797_229003 - Class II

Cleavage pHMM score: -1.40

RODEO score: 0

Monoisotopic mass: 5121.8 Da

Molecular weight: 5124.9 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 5142.9 Da N = 1; 5160.9 Da N = 2; 5178.9 Da N = 3; 5196.9 Da N = 4; 5215.0 Da N = 5; 5233.0 Da N = 6

allorf_228993_229076 - Class II

Cleavage pHMM score: -7.00

RODEO score: 0

Monoisotopic mass: 2154.1 Da

Molecular weight: 2155.4 Da

Number of bridges: 1

allorf_232870_232962 - Class II

Cleavage pHMM score: -7.00

RODEO score: 0

Monoisotopic mass: 725.3 Da

Molecular weight: 725.8 Da

Number of bridges: 1

allorf_232888_233061 - Class II

Cleavage pHMM score: -4.20

RODEO score: 0

Monoisotopic mass: 3814.9 Da

Molecular weight: 3817.1 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3835.2 Da N = 1; 3853.2 Da N = 2; 3871.2 Da N = 3; 3889.2 Da N = 4; 3907.2 Da N = 5

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate