Select genomic region:
Overview
1.1
1.2
1.3
1.4
1.5
1.6
1.7
2.1
2.2
3.1
3.2
5.1
6.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_ML974127.1 (Halorussus salinus)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | NI-siderophore | 184,920 | 218,977 | Medium | schizokinen | NRPS:Type IV
Region 1.2 | terpene | 433,666 | 454,613 |
Region 1.3 | lanthipeptide-class-ii | 475,603 | 498,899 |
Region 1.4 | terpene | 782,126 | 803,079 |
Region 1.5 | lanthipeptide-class-ii | 1,455,720 | 1,479,109 |
Region 1.6 | azole-containing-RiPP,lanthipeptide-class-ii | 1,527,162 | 1,568,330 | High | archalan α | ribosomal:RiPP
Region 1.7 | terpene-precursor | 1,573,391 | 1,585,202 |

NZ_ML974128.1 (Halorussus salinus)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 2.1 | terpene | 100,544 | 120,885 |
Region 2.2 | RiPP-like | 355,327 | 367,147 |

NZ_SBIS02000007.1 (Halorussus salinus)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 3.1 | lanthipeptide-class-ii | 22,163 | 45,384 |
Region 3.2 | azole-containing-RiPP | 354,479 | 378,801 |

NZ_ML974129.1 (Halorussus salinus)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 5.1 | terpene | 208,496 | 229,578 |

NZ_SBIS02000011.1 (Halorussus salinus)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 6.1 | lanthipeptide-class-ii,triceptide,terpene-precursor | 167,395 | 233,689 | High | archalan β | ribosomal:RiPP

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | NI-siderophore | 184,920 | 218,977 | Medium | schizokinen | NRPS:Type IV
Region 1.2 | terpene | 433,666 | 454,613 |
Region 1.3 | lanthipeptide-class-ii | 475,603 | 498,899 |
Region 1.4 | terpene | 782,126 | 803,079 |
Region 1.5 | lanthipeptide-class-ii | 1,455,720 | 1,479,109 |
Region 1.6 | azole-containing-RiPP,lanthipeptide-class-ii | 1,527,162 | 1,568,330 | High | archalan α | ribosomal:RiPP
Region 1.7 | terpene-precursor | 1,573,391 | 1,585,202 |
Region 2.1 | terpene | 100,544 | 120,885 |
Region 2.2 | RiPP-like | 355,327 | 367,147 |
Region 3.1 | lanthipeptide-class-ii | 22,163 | 45,384 |
Region 3.2 | azole-containing-RiPP | 354,479 | 378,801 |
Region 5.1 | terpene | 208,496 | 229,578 |
Region 6.1 | lanthipeptide-class-ii,triceptide,terpene-precursor | 167,395 | 233,689 | High | archalan β | ribosomal:RiPP

No secondary metabolite regions were found in these records:
  NZ_SBIS02000008.1 (Halorussus salinus)
  NZ_SBIS02000012.1 (Halorussus salinus)
  NZ_SBIS02000013.1 (Halorussus salinus)
  NZ_SBIS02000014.1 (Halorussus salinus)
  NZ_SBIS02000015.1 (Halorussus salinus)
  NZ_SBIS02000016.1 (Halorussus salinus)

Compact view
NZ_ML974127.1 - Region 1 - NI-siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 184,920 - 218,977 nt. (total: 34,058 nt) Show pHMM detection rules used
NI-siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase oxygenase
EPL00_RS01000: lysine/ornithine N-monooxygenase

smcogs
  SMCOG1080: lysine/ornithine N-monooxygenase

EPL00_RS01015: aldo/keto reductase family oxidoreductase

smcogs
  SMCOG1039: aldo/keto reductase family oxidoreductase

Transferases: aminotransferase
EPL00_RS00980: aminotransferase class-III

smcogs
  SMCOG1013: aminotransferase class-III

Lyases: decarboxylase
EPL00_RS00985: Decarboxylase, pyridoxal-dependent

smcogs
  SMCOG1180: Decarboxylase, pyridoxal-dependent

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NI-siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002469.2 |  | 0.67 | other (other) | woodybactin A, woodybactin B, woodybactin C, woodybactin D | Shewanella woodyi ATCC 51908
BGC0002633.2 |  | 0.66 | other (other) | schizokinen | Leptolyngbya sp. PCC 7376
BGC0002683.2 |  | 0.65 | NRPS | schizokinen | Nostoc sp. PCC 7120 = FACHB-418
BGC0001572.3 |  | 0.64 | other (other) | desferrioxamine E | Pantoea agglomerans
BGC0002692.2 |  | 0.64 | other (other) | speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B | Kribbella speibonae
BGC0001478.5 |  | 0.61 | other (other) | desferrioxamine E | Streptomyces sp. ID38640
BGC0000941.3 |  | 0.60 | other (other) | desferrioxamin B | Streptomyces griseus subsp. griseus NBRC 13350
BGC0002305.2 |  | 0.59 | other (other) | legonoxamine A, desferrioxamine B, legonoxamine B | Streptomyces sp.
BGC0002470.2 |  | 0.58 | other (other) | synechobactin C9, synechobactin C11, synechobactin 13, synechobactin 14, synechobactin 16, synechobactin A, synechobactin B, synechobactin C | Synechococcus sp. PCC 7002
BGC0001713.5 |  | 0.57 | other (other) | ochrobactin | Ochrobactrum anthropi

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002469.2 |  | 0.67 | other (other) | woodybactin A, woodybactin B, woodybactin C, woodybactin D | Shewanella woodyi ATCC 51908
BGC0002633.2 |  | 0.66 | other (other) | schizokinen | Leptolyngbya sp. PCC 7376
BGC0002683.2 |  | 0.65 | NRPS | schizokinen | Nostoc sp. PCC 7120 = FACHB-418
BGC0001572.3 |  | 0.64 | other (other) | desferrioxamine E | Pantoea agglomerans
BGC0002692.2 |  | 0.64 | other (other) | speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B | Kribbella speibonae
BGC0001478.5 |  | 0.61 | other (other) | desferrioxamine E | Streptomyces sp. ID38640
BGC0000941.3 |  | 0.60 | other (other) | desferrioxamin B | Streptomyces griseus subsp. griseus NBRC 13350
BGC0002305.2 |  | 0.59 | other (other) | legonoxamine A, desferrioxamine B, legonoxamine B | Streptomyces sp.
BGC0002470.2 |  | 0.58 | other (other) | synechobactin C9, synechobactin C11, synechobactin 13, synechobactin 14, synechobactin 16, synechobactin A, synechobactin B, synechobactin C | Synechococcus sp. PCC 7002
BGC0001713.5 |  | 0.57 | other (other) | ochrobactin | Ochrobactrum anthropi

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

NZ_ML974127.1 - Region 2 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 433,666 - 454,613 nt. (total: 20,948 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase reductase
EPL00_RS02210: alcohol dehydrogenase

smcogs
  SMCOG1040: alcohol dehydrogenase

EPL00_RS02275: alkyl hydroperoxide reductase/ Thiol specific

smcogs
  SMCOG1196: alkyl hydroperoxide reductase/ Thiol specific

Transferases: glycosyltransferase
EPL00_RS02200: glycosyl transferase group 1

smcogs
  SMCOG1045: glycosyl transferase group 1

Hydrolases: hydrolase
EPL00_RS02175: metallo-beta-lactamase family protein

smcogs
  SMCOG1170: metallo-beta-lactamase family protein

EPL00_RS02190: metallo-beta-lactamase family protein

smcogs
  SMCOG1170: metallo-beta-lactamase family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001410.3 |  | 0.40 | saccharide | polysaccharide A | Bacteroides fragilis
BGC0001195.3 |  | 0.27 | NRPS, PKS | nocardiopsin A, nocardiopsin B, nocardiopsin C, nocardiopsin D | Nocardiopsis sp. CMB-M0232

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001410.3 |  | 0.40 | saccharide | polysaccharide A | Bacteroides fragilis
BGC0001195.3 |  | 0.27 | NRPS, PKS | nocardiopsin A, nocardiopsin B, nocardiopsin C, nocardiopsin D | Nocardiopsis sp. CMB-M0232

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
tetraterpene | C40 carotenoid |  | C40 | unknown | unknown

Genes with terpene domains:
EPL00_RS02225: Lycopene_cycl + Lycopene_cycl
Domain 1 (6 - 97): Lycopene cyclase

Reactions:
  C40_carotenoid → C40_carotenoid

Domain 2 (170 - 258): Lycopene cyclase

Reactions:
  C40_carotenoid → C40_carotenoid

Terpene
Glossary
Glossary showing acronyms and their full names.
No acronyms to display
NZ_ML974127.1 - Region 3 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 475,603 - 498,899 nt. (total: 23,297 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: cyclase
EPL00_RS02450: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002703.2 |  | 0.49 | ribosomal | archalan α | Halorussus salinus
BGC0000554.4 |  | 0.48 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001579.4 |  | 0.47 | ribosomal | duramycin | Streptomyces cinnamoneus
BGC0000528.5 |  | 0.46 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001226.4 |  | 0.44 | ribosomal | streptocollin | Streptomyces collinus Tu 365
BGC0000563.4 |  | 0.44 | ribosomal | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0000503.5 |  | 0.43 | ribosomal | cinnamycin | Streptomyces cinnamoneus
BGC0002704.2 |  | 0.42 | ribosomal | archalan β | Halorussus salinus
BGC0001660.3 |  | 0.41 | ribosomal | mathermycin | Marinactinospora thermotolerans
BGC0001210.5 |  | 0.41 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002703.2 |  | 0.49 | ribosomal | archalan α | Halorussus salinus
BGC0000554.4 |  | 0.48 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001579.4 |  | 0.47 | ribosomal | duramycin | Streptomyces cinnamoneus
BGC0000528.5 |  | 0.46 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001226.4 |  | 0.44 | ribosomal | streptocollin | Streptomyces collinus Tu 365
BGC0000563.4 |  | 0.44 | ribosomal | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0000503.5 |  | 0.43 | ribosomal | cinnamycin | Streptomyces cinnamoneus
BGC0002704.2 |  | 0.42 | ribosomal | archalan β | Halorussus salinus
BGC0001660.3 |  | 0.41 | ribosomal | mathermycin | Marinactinospora thermotolerans
BGC0001210.5 |  | 0.41 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for EPL00_RS02450

EPL00_RS02405
Leader:
MDESLLADWVRRSPSLDAILDSSARTAISDDFVPDDLLAEWRDVFDADADFRDRLRFA
Core:
D W T P E E T C D R P N P S E I I
Core with dehydrations:
D W Dhb P E E Dhb Cys D R P N P Dha E I I

#### antiSMASH-DB 4.0 matches for EPL00_RS02405

100.0%
NZ_ML974127.1:
Lanthipeptides: EPL00_RS02405_lanthipeptide
1
D W T P E E T C D R P N P S E I I
17
D W T P E E T C D R P N P S E I I
1
D W T P E E T C D R P N P S E I I
17
33.3%
NZ_CP117416.1 and 5 others:
NZ_CP117876.1 Lassopeptides: PQ460_RS19020_lassopeptide NZ_CP117876.1 Lassopeptides: PQ460_RS19030_lassopeptide NZ_JAQQZQ010000001.1 Lassopeptides: PO903_RS10225_lassopeptide NZ_JAQQZQ010000001.1 Lassopeptides: PO903_RS10220_lassopeptide NZ_JAQQZQ010000001.1 Lassopeptides: PO903_RS10215_lassopeptide
Lassopeptides: PQ456_RS04840_lassopeptide
1
D W T P E E T C D R P N P S
14
D W E+ D N P S
8
D W V S E Q D A D L Y N P S
21
33.3%
NZ_CP117876.1:
Lassopeptides: PQ460_RS19025_lassopeptide
1
D W T P E E T C D R P N P S
14
D W E D N P S
8
D W V S E H D A D L F N P S
21
with 12 more sequence matches
Only the first 10 are displayed here.
31.8%
NZ_FNNT01000001.1:
Lassopeptides: BLW49_RS28475_lassopeptide
1
D W T P E E T C D R P N P S
14
D W E D N P S
9
D W I S E H D G D L Y N P S
22
28.6%
NC_014483.2 and 10 others:
NC_023037.2 Lassopeptides: X809_RS27480_lassopeptide NZ_CP011420.1 Lassopeptides: VK72_RS27415_lassopeptide NZ_CP017967.2 Lassopeptides: PPYC1_RS06115_lassopeptide NZ_CP017968.3 Lassopeptides: PPYC2_RS06795_lassopeptide NZ_CP073682.1 Lassopeptides: KAI36_RS06145_lassopeptide NZ_CP073683.1 Lassopeptides: KAI37_RS05910_lassopeptide NZ_CP109848.1 Lassopeptides: OF859_RS24335_lassopeptide NZ_CP113973.1 Lassopeptides: OYT09_RS06050_lassopeptide NZ_FOYG01000001.1 Lassopeptides: BM358_RS26180_lassopeptide NZ_PTJM01000055.1 Lassopeptides: C5G87_RS12815_lassopeptide
Lassopeptides: PPE_RS25060_lassopeptide
1
D W T P E E T C D R P N P S
14
D W + D N P S
8
D W V S D H D A D L H N P S
21
28.6%
NC_014622.2 and 26 others:
NC_016641.1 Lassopeptides: HPL003_RS28495_lassopeptide NC_017542.1 Lassopeptides: PPM_RS29155_lassopeptide NZ_CP006872.1 Lassopeptides: PPSQR21_RS25845_lassopeptide NZ_CP020028.1 Lassopeptides: B4V02_RS25945_lassopeptide NZ_CP023711.1 Lassopeptides: CPY53_RS20730_lassopeptide NZ_CP025696.1 Lassopeptides: C0638_RS25110_lassopeptide NZ_CP025957.1 Lassopeptides: C1A50_RS25040_lassopeptide NZ_CP029370.1 Lassopeptides: DI243_RS05990_lassopeptide NZ_CP034141.1 Lassopeptides: EGM68_RS06425_lassopeptide NZ_CP040829.1 Lassopeptides: FGY93_RS02005_lassopeptide NZ_CP041731.1 Lassopeptides: FOA15_RS11830_lassopeptide NZ_CP042272.1 Lassopeptides: FQU75_RS22710_lassopeptide NZ_CP049598.1 Lassopeptides: G7L40_RS02540_lassopeptide NZ_CP084033.1 Lassopeptides: LAZ93_RS06040_lassopeptide NZ_CP085682.1 Lassopeptides: LJR53_RS05900_lassopeptide NZ_CP086373.1 Lassopeptides: LMH85_RS06275_lassopeptide NZ_CP092779.1 Lassopeptides: MJ749_RS05940_lassopeptide NZ_CP097766.1 Lassopeptides: MF620_RS06000_lassopeptide NZ_CP102865.1 Lassopeptides: NWS42_RS19270_lassopeptide NZ_FNYX01000001.1 Lassopeptides: BMY87_RS25010_lassopeptide NZ_JAOYTP010000002.1 Lassopeptides: OIU26_RS08460_lassopeptide NZ_JWJJ01000002.1 Lassopeptides: U707_RS25590_lassopeptide NZ_LNZF01000001.1 Lassopeptides: AVK83_RS26330_lassopeptide NZ_PNXP01000013.1 Lassopeptides: C1I59_RS05635_lassopeptide NZ_PNXQ01000012.1 Lassopeptides: C1I60_RS12180_lassopeptide NZ_POVT01000017.1 Lassopeptides: C1T20_RS25045_lassopeptide
Lassopeptides: PPSC2_RS58945_lassopeptide
1
D W T P E E T C D R P N P S
14
D W + D N P S
8
D W V S D H D A D L Y N P S
21
28.6%
NZ_BMMB01000001.1 and 4 others:
NZ_BMMB01000001.1 Lassopeptides: IEX62_RS00125_lassopeptide NZ_CP013023.1 Lassopeptides: AR543_RS24045_lassopeptide NZ_KQ040793.1 Lassopeptides: WH45_RS23340_lassopeptide NZ_KQ040798.1 Lassopeptides: WH46_RS23990_lassopeptide
Lassopeptides: IEX62_RS00120_lassopeptide
1
D W T P E E T C D R P N P S
14
D W + D N P S
8
D W V T Y D D A D L Y N P S
21
28.6%
NZ_CP013203.1:
Lassopeptides: ASL14_RS05780_lassopeptide
1
D W T P E E T C D R P N P S
14
D W + D N P S
8
D W V S D H D A D L V N P S
21
28.6%
NZ_CP015423.1 and 9 others:
NZ_CP061172.1 Lassopeptides: IAQ67_RS05910_lassopeptide NZ_CP071875.1 Lassopeptides: J4I02_RS06550_lassopeptide NZ_CP092831.1 Lassopeptides: MLD56_RS06365_lassopeptide NZ_JAAMNR010000001.1 Lassopeptides: G9G54_RS05075_lassopeptide NZ_JAFJXZ010000012.1 Lassopeptides: JYU28_RS05205_lassopeptide NZ_JAKVDC010000001.1 Lassopeptides: MKN04_RS01225_lassopeptide NZ_JANAVI010000007.1 Lassopeptides: NLX74_RS16260_lassopeptide NZ_JANAVN010000010.1 Lassopeptides: NLX78_RS16305_lassopeptide NZ_POVS01000014.1 Lassopeptides: C1T21_RS27040_lassopeptide
Lassopeptides: AOU00_RS26345_lassopeptide
1
D W T P E E T C D R P N P S
14
D W + D N P S
8
D W V S D H D A D I Y N P S
21
28.6%
NZ_CP033873.1:
Lassopeptides: CSW63_RS23970_lassopeptide
1
D W T P E E T C D R P
11
D+ P E +C+R P
4
D F I P E F S C E R P
14
28.6%
NZ_CP117416.1:
Lassopeptides: PQ456_RS04830_lassopeptide
1
D W T P E E T C D R P N P S
14
D W ++ D N P S
8
D W V S D Q D A D L Y N P S
21
27.3%
NZ_CP118101.1 and 2 others:
NZ_CP118106.1 Lassopeptides: PUW24_RS15770_lassopeptide NZ_FPAC01000001.1 Lassopeptides: BM415_RS24635_lassopeptide
Lassopeptides: PUW23_RS08415_lassopeptide
1
D W T P E E T C D R P N P S
14
D W E D +P S
9
D W I S E H D A D L Y D P S
22
18.8%
NZ_FNDJ01000037.1:
Lanthipeptides: allorf_006346_006582_lanthipeptide
4
P E E T C D R P N P
13
P T C R P P
20
P A A T C R R P A P
29
allorf_0489183_0489356
Leader:
MASRRTVVSSVVHAVRVALHAVITG
Core:
V C G S P N R R G R R R G G N R S P C E R R G W V L S L D K I F
Core with dehydrations:
V Cys G Dha P N R R G R R R G G N R Dha P Cys E R R G W V L Dha L D K I F

#### antiSMASH-DB 4.0 matches for allorf_0489183_0489356

100.0%
NZ_ML974127.1:
Lanthipeptides: allorf_0489183_0489356_lanthipeptide
1
V C G S P N R R G R R R G G N R S P C E R R G W V L S L D K I F
32
V C G S P N R R G R R R G G N R S P C E R R G W V L S L D K I F
1
V C G S P N R R G R R R G G N R S P C E R R G W V L S L D K I F
32
32.4%
NZ_CP041604.2 and 3 others:
NZ_CP041610.2 Lanthipeptides: allorf_00763119_00763355_lanthipeptide NZ_CP041611.1 Lanthipeptides: allorf_00813099_00813335_lanthipeptide NZ_CP041650.2 Lanthipeptides: allorf_01115923_01116159_lanthipeptide
Lanthipeptides: allorf_01200858_01201094_lanthipeptide
9
G R R R G--G N R S P C E R R
22
G R R R G+R S P C R R
10
G R R R P W P G H R S P C P R R
25
28.6%
NZ_FOWL01000011.1:
Lanthipeptides: allorf_022376_022519_lanthipeptide
8
R G R R R G G N R S P C E R R G W V L S L
28
R R+G P R R G W S L
7
R A A R Q G P E T G P G R R R G W A F S L
27
with 3 more sequence matches
18.8%
NZ_CP011130.1:
Lanthipeptides: allorf_5346585_5346695_lanthipeptide
14
G N R S P C E R R G W V
25
G N P C R W
4
G N S G P C A S R A W T
15
15.6%
NZ_LUCO01000008.1:
Lanthipeptides: allorf_089261_089395_lanthipeptide
19
C E R R G W V L S
27
C E R ++L S
9
C E R E A Y I L S
17
13.8%
NZ_CP003987.1:
Lanthipeptides: allorf_00516755_00516991_lanthipeptide
4
S P N R R G R R R G G N R S P C
19
S P R R R G G P C
27
S P G S L A R R R G G A T C P C
42
allorf_0493198_0493422
Leader:
MRGASRRICERWNREQGSGG
Core:
Y V G Q R P R A C G G F L R P R L R L R P R L R Q H R Q H R R R F R R L R T Q Q R Q H S H G L R R P R P Q L
Core with dehydrations:
Y V G Q R P R A Cys G G F L R P R L R L R P R L R Q H R Q H R R R F R R L R Dhb Q Q R Q H Dha H G L R R P R P Q L

#### antiSMASH-DB 4.0 matches for allorf_0493198_0493422

100.0%
NZ_ML974127.1:
Lanthipeptides: allorf_0493198_0493422_lanthipeptide
1
Y V G Q R P R A C G G F L R P R L R L R P R L R Q H R Q H R R R F R R L R T Q Q R Q H S H G L R R P R P Q L
54
Y V G Q R P R A C G G F L R P R L R L R P R L R Q H R Q H R R R F R R L R T Q Q R Q H S H G L R R P R P Q L
1
Y V G Q R P R A C G G F L R P R L R L R P R L R Q H R Q H R R R F R R L R T Q Q R Q H S H G L R R P R P Q L
54
20.4%
NZ_LZRD01000031.1:
Lanthipeptides: allorf_12002_12133_lanthipeptide
9
C G G----F L R P R L R L R P R L R Q H R Q H R R R F
33
C G G L P R R R P R+ R+ +
2
C G G P L V T V L A P R P R D R P R V T S G R K P W K A V
30
18.5%
NZ_RAII01000001.1:
Lanthipeptides: allorf_2955953_2956186_lanthipeptide
34
R R L R T Q Q R Q H S H G L R R P R P Q L
54
R R Q R Q H+ +R P R +L
17
R T T R G Q W R Q H A V T A K R P R A R L
37
with 1 more sequence matches
13.0%
NZ_CP071090.1:
Lanthipeptides: allorf_11048315_11048452_lanthipeptide
3
G Q R P R A C G G F L R P R L R L R P R L R Q H R Q H R R R F R R L
36
G+R P R C P +R + + + +
1
G E R P R V C K S I Q A P T H A M R C T V V T S K T Y V E T T T A I
34

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Lanthipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

EPL00_RS02405 - Class II
  Cleavage pHMM score: -5.60
  RODEO score: 0
  Monoisotopic mass: 1946.9 Da
  Molecular weight: 1948.1 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1966.1 Da N = 1
    1984.1 Da N = 2
allorf_0489183_0489356 - Class II
  Cleavage pHMM score: -5.90
  RODEO score: 0
  Monoisotopic mass: 3629.9 Da
  Molecular weight: 3632.1 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3650.2 Da N = 1
allorf_0493198_0493422 - Class II
  Cleavage pHMM score: -6.10
  RODEO score: 0
  Monoisotopic mass: 6815.9 Da
  Molecular weight: 6819.9 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    6837.9 Da N = 1

NZ_ML974127.1 - Region 4 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 782,126 - 803,079 nt. (total: 20,954 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: deacetylase
EPL00_RS04045: acetylornithine deacetylase

smcogs
  SMCOG1247: acetylornithine deacetylase

Lyases: decarboxylase lyase
EPL00_RS04025: argininosuccinate lyase/adenylosuccinate lyase

smcogs
  SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

EPL00_RS04055: diaminopimelate decarboxylase

smcogs
  SMCOG1264: diaminopimelate decarboxylase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000645.3 |  | 0.42 | terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0002645.3 |  | 0.40 | other (other) | fluopsin C | Pseudomonas aeruginosa PAO1
BGC0000664.5 |  | 0.40 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000633.3 |  | 0.40 | terpene | carotenoid | Streptomyces avermitilis
BGC0001227.3 |  | 0.39 | terpene | isorenieratene | Streptomyces collinus Tu 365
BGC0001456.3 |  | 0.39 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000648.3 |  | 0.37 | terpene | carotenoid | Myxococcus xanthus
BGC0000663.5 |  | 0.36 | terpene | hopene | Streptomyces coelicolor A3(2)
BGC0000494.5 |  | 0.33 | ribosomal | uberolysin | Streptococcus uberis
BGC0002499.2 |  | 0.30 | NRPS, PKS | enteromycin | Streptomyces achromogenes subsp. streptozoticus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000645.3 |  | 0.42 | terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0002645.3 |  | 0.40 | other (other) | fluopsin C | Pseudomonas aeruginosa PAO1
BGC0000664.5 |  | 0.40 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000633.3 |  | 0.40 | terpene | carotenoid | Streptomyces avermitilis
BGC0001227.3 |  | 0.39 | terpene | isorenieratene | Streptomyces collinus Tu 365
BGC0001456.3 |  | 0.39 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000648.3 |  | 0.37 | terpene | carotenoid | Myxococcus xanthus
BGC0000663.5 |  | 0.36 | terpene | hopene | Streptomyces coelicolor A3(2)
BGC0000494.5 |  | 0.33 | ribosomal | uberolysin | Streptococcus uberis
BGC0002499.2 |  | 0.30 | NRPS, PKS | enteromycin | Streptomyces achromogenes subsp. streptozoticus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene | C30 carotenoid | diapophytoene | C30 | acyclic | none
triterpene |  | squalene | C30 | acyclic | none
triterpene |  | PSPP | C30 | acyclic | PP
tetraterpene | C40 carotenoid | phytoene | C40 | acyclic | none
triterpene |  | hydroxysqualene | C30 | acyclic | OH

Genes with terpene domains:
EPL00_RS04015: PT_phytoene_like
Domain 1 (8 - 280): Prenyltransferase; Phytoene synthase like
Subtype: unknown

Reactions:
  FPP → diapophytoene
  FPP → squalene
  FPP → PSPP
  GGPP → phytoene
  PSPP → hydroxysqualene

Terpene
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
FPP | Farnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
PP | Diphosphate
PSPP | Presqualene diphosphate

NZ_ML974127.1 - Region 5 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,455,720 - 1,479,109 nt. (total: 23,390 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: methyltransferase
EPL00_RS07370: methyltransferase

smcogs
  SMCOG1089: methyltransferase

Lyases: cyclase
EPL00_RS07375: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001217.5 |  | 0.52 | other (other) | PreQ0 Base | Streptomyces qinglanensis
BGC0002704.2 |  | 0.51 | ribosomal | archalan β | Halorussus salinus
BGC0002703.2 |  | 0.50 | ribosomal | archalan α | Halorussus salinus
BGC0000554.4 |  | 0.48 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001579.4 |  | 0.47 | ribosomal | duramycin | Streptomyces cinnamoneus
BGC0000802.5 |  | 0.46 | saccharide | succinoglycan | Sinorhizobium meliloti
BGC0000528.5 |  | 0.46 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000563.4 |  | 0.44 | ribosomal | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0001226.4 |  | 0.44 | ribosomal | streptocollin | Streptomyces collinus Tu 365
BGC0001210.5 |  | 0.43 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001217.5 |  | 0.52 | other (other) | PreQ0 Base | Streptomyces qinglanensis
BGC0002704.2 |  | 0.51 | ribosomal | archalan β | Halorussus salinus
BGC0002703.2 |  | 0.50 | ribosomal | archalan α | Halorussus salinus
BGC0000554.4 |  | 0.48 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001579.4 |  | 0.47 | ribosomal | duramycin | Streptomyces cinnamoneus
BGC0000802.5 |  | 0.46 | saccharide | succinoglycan | Sinorhizobium meliloti
BGC0000528.5 |  | 0.46 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000563.4 |  | 0.44 | ribosomal | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0001226.4 |  | 0.44 | ribosomal | streptocollin | Streptomyces collinus Tu 365
BGC0001210.5 |  | 0.43 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for EPL00_RS07375

EPL00_RS07380
Leader:
MAVSDGPPIGIRHPTVNPTPDAAIAQSRSGA
Core:
C E C V D C G Y V V G T D D D L P P K C P D C G G A L T F V R S
Core with dehydrations:
Cys E Cys V D Cys G Y V V G Dhb D D D L P P K Cys P D Cys G G A L Dhb F V R Dha

#### antiSMASH-DB 4.0 matches for EPL00_RS07380

100.0%
NZ_ML974127.1:
Lanthipeptides: EPL00_RS07380_lanthipeptide
1
C E C V D C G Y V V G T D D D L P P K C P D C G G A L T F V R S
32
C E C V D C G Y V V G T D D D L P P K C P D C G G A L T F V R S
1
C E C V D C G Y V V G T D D D L P P K C P D C G G A L T F V R S
32
25.6%
NZ_CP096019.1:
Lanthipeptides: MW046_RS07405_lanthipeptide
2
E C V D C G Y V V G T D D------D L P P-----K C P D C G G A L T F V R
31
C++C G+ D +P P +C P+C G R
2
R C L N C G F E A P H D G G E W N S A Q V P P L G D L M R C P E C G S T N I L G R
42
17.4%
NZ_CP096019.1:
Lanthipeptides: MW046_RS07480_lanthipeptide
15
D L P P K C P D C G G A L T F V
30
D +C P D C G G + V
5
D T D R E C P D C G G P V V S V
20
with 2 more sequence matches
16.7%
NZ_BNBJ01000003.1 and 3 others:
NZ_CP079114.1 Lanthipeptides: allorf_4422232_4422378_lanthipeptide NZ_JALDPQ010000054.1 Lanthipeptides: allorf_130072_130218_lanthipeptide NZ_JAMFLF010000021.1 Lanthipeptides: allorf_031162_031308_lanthipeptide
Lanthipeptides: allorf_023668_023814_lanthipeptide
19
K C P D C G G A L T F V
30
+C P G G A F+
10
R C P S E G G A E E F I
21
15.2%
NZ_CP096658.1 and 1 other:
NZ_ML974127.1 Lanthipeptides: EPL00_RS07765_lanthipeptide
Lanthipeptides: M0R88_RS16185_lanthipeptide
19
K C P D C G G A L T F V
30
+C P D C G G + V
9
E C P D C G G D V L E V
20
allorf_1457905_1457976
Leader:
MSAEKPSEDEFRGA
Core:
S E S R H R C G V
Core with dehydrations:
Dha E Dha R H R Cys G V

#### antiSMASH-DB 4.0 matches for allorf_1457905_1457976

100.0%
NZ_ML974127.1:
Lanthipeptides: allorf_1457905_1457976_lanthipeptide
1
S E S R H R C G V
9
S E S R H R C G V
1
S E S R H R C G V
9
25.0%
NZ_KB900614.1:
Lanthipeptides: allorf_2951591_2951809_lanthipeptide
1
S E S R H R C G
8
+E R+R C G
5
A E V R Y R C G
12
allorf_1470722_1470832
Leader:
MPISSIDLIQSPQLPSSAYS
Core:
R V Y Q E G L S V F R T C R L S
Core with dehydrations:
R V Y Q E G L Dha V F R Dhb Cys R L Dha

#### antiSMASH-DB 4.0 matches for allorf_1470722_1470832

100.0%
NZ_ML974127.1:
Lanthipeptides: allorf_1470722_1470832_lanthipeptide
1
R V Y Q E G L S V F R T C R L S
16
R V Y Q E G L S V F R T C R L S
1
R V Y Q E G L S V F R T C R L S
16
24.1%
NZ_FMTR01000020.1 and 4 others:
NZ_FMXH01000021.1 Lanthipeptides: allorf_013379_013498_lanthipeptide NZ_FNNL01000019.1 Lanthipeptides: allorf_013061_013180_lanthipeptide NZ_FNYG01000024.1 Lanthipeptides: allorf_013147_013266_lanthipeptide NZ_FOTH01000039.1 Lanthipeptides: allorf_32773_32892_lanthipeptide
Lanthipeptides: allorf_013814_013933_lanthipeptide
1
R V Y Q E G L S V F
10
R V ++G L S V F
17
R V C R K G L S V F
26
allorf_1476445_1476564
Leader:
MVGERCRILVHCPRPGGTRTSDGS
Core:
R I Q C Q W L P V L A T H R A
Core with dehydrations:
R I Q Cys Q W L P V L A Dhb H R A

#### antiSMASH-DB 4.0 matches for allorf_1476445_1476564

100.0%
NZ_ML974127.1:
Lanthipeptides: allorf_1476445_1476564_lanthipeptide
1
R I Q C Q W L P V L A T H R A
15
R I Q C Q W L P V L A T H R A
1
R I Q C Q W L P V L A T H R A
15
18.5%
NZ_SWMS01000001.1:
Lassopeptides: allorf_785281_785463_lassopeptide
3
Q C Q W L P V L A
11
W L P V L
10
N L S W L P V L G
18

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Lanthipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

EPL00_RS07380 - Class II
  Cleavage pHMM score: -6.80
  RODEO score: 0
  Monoisotopic mass: 3279.4 Da
  Molecular weight: 3281.7 Da
  Number of bridges: 3
allorf_1457905_1457976 - Class II
  Cleavage pHMM score: -6.60
  RODEO score: 0
  Monoisotopic mass: 993.5 Da
  Molecular weight: 994.1 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1012.1 Da N = 1
allorf_1470722_1470832 - Class II
  Cleavage pHMM score: -6.10
  RODEO score: 0
  Monoisotopic mass: 1859.0 Da
  Molecular weight: 1860.1 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1878.2 Da N = 1
    1896.2 Da N = 2
allorf_1476445_1476564 - Class II
  Cleavage pHMM score: -7.00
  RODEO score: 0
  Monoisotopic mass: 1773.0 Da
  Molecular weight: 1774.1 Da
  Number of bridges: 1

NZ_ML974127.1 - Region 6 - azole-containing-RiPP,lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,527,162 - 1,568,330 nt. (total: 41,169 nt) Show pHMM detection rules used
azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
Azole RiPPs
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
EPL00_RS07660: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs
  SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: aminotransferase
EPL00_RS07700: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Lyases: cyclase
EPL00_RS07790: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Ligases: synthase
EPL00_RS07690: carbamoyl phosphate synthase small subunit

smcogs
  SMCOG1249: carbamoyl phosphate synthase small subunit

Translocases: permease
EPL00_RS07740: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | azole-containing-RiPP | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0002703.2 |  |  | 0.78 | ribosomal | archalan α | Halorussus salinus
BGC0000554.4 |  |  | 0.17 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001937.4 |  |  | 0.16 | other (other) | tubercidin | Streptomyces tubercidicus
BGC0002013.4 |  |  | 0.15 | ribosomal | curacozole | Streptomyces curacoi
BGC0000881.3 |  |  | 0.15 | other (other) | toyocamycin | Streptomyces ahygroscopicus subsp. wuzhouensis
BGC0001808.5 |  |  | 0.15 | other (other) | toyocamycin | Streptomyces diastatochromogenes
BGC0000041.3 |  |  | 0.13 | PKS | oronofacic acid | Pseudomonas syringae
BGC0002031.3 |  |  | 0.13 | other (other) | kitasetaline | Kitasatospora setae KM-6054
BGC0002704.2 |  |  | 0.13 | ribosomal | archalan β | Halorussus salinus
BGC0000504.5 |  |  | 0.13 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002703.2 |  | 0.92 | ribosomal | archalan α | Halorussus salinus
BGC0000554.4 |  | 0.48 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0002704.2 |  | 0.47 | ribosomal | archalan β | Halorussus salinus
BGC0000504.5 |  | 0.46 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0002013.4 |  | 0.45 | ribosomal | curacozole | Streptomyces curacoi
BGC0000517.4 |  | 0.44 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0002699.2 |  | 0.43 | ribosomal | nostolysamide A, nostolysamide B | Nostoc punctiforme PCC 73102
BGC0000041.3 |  | 0.42 | PKS | oronofacic acid | Pseudomonas syringae
BGC0002031.3 |  | 0.42 | other (other) | kitasetaline | Kitasatospora setae KM-6054
BGC0001187.4 |  | 0.41 | NRPS, PKS | xenolozoyenone | Glarea lozoyensis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for EPL00_RS07790

EPL00_RS07765
Leader:
MADNRVVQGRMVTPAALAEMIEGEDVMDA
Core:
E A I S E T D R E C P D C G G D V L E V G Y M P S V T E F V T G W K C Q D C D W A D T D R D
Core with dehydrations:
E A I Dha E Dhb D R E Cys P D Cys G G D V L E V G Y M P Dha V Dhb E F V Dhb G W K Cys Q D Cys D W A D Dhb D R D

#### antiSMASH-DB 4.0 matches for EPL00_RS07765

100.0%
NZ_CP096658.1 and 1 other:
NZ_ML974127.1 Lanthipeptides: EPL00_RS07765_lanthipeptide
Lanthipeptides: M0R88_RS16185_lanthipeptide
1
E A I S E T D R E C P D C G G D V L E V G Y M P S V T E F V T G W K C Q D C D W A D T D R D
46
E A I S E T D R E C P D C G G D V L E V G Y M P S V T E F V T G W K C Q D C D W A D T D R D
1
E A I S E T D R E C P D C G G D V L E V G Y M P S V T E F V T G W K C Q D C D W A D T D R D
46
84.8%
NZ_CP119804.1:
Lanthipeptides: P2T57_RS03940_lanthipeptide
1
E A I S E T D R E C P D C G G D V L E V G Y M P S V T E F V T G W K C Q D C D W A D T D R D
46
E+I +T D R E C P D C G D V L E V G Y M P S V T E F V T G W K C Q+C D W+D T D R+
1
E S I E D T D R E C P D C G E D V L E V G Y M P S V T E F V T G W K C Q E C D W S D T D R E
46
78.3%
NZ_CP096019.1:
Lanthipeptides: MW046_RS07480_lanthipeptide
1
E A I S E T D R E C P D C G G D V L E V G Y M P S V T E F V T G W K C Q D C D W A D T D R D
46
E+I S+T D R E C P D C G G V+ V G Y M P S V E F V T G+K C Q D C D W T D R+
1
E S I S D T D R E C P D C G G P V V S V G Y M P S V M E F V T G Y K C Q D C D W K A T D R E
46
with 2 more sequence matches
15.2%
NZ_ML974127.1:
Lanthipeptides: EPL00_RS07380_lanthipeptide
9
E C P D C G G D V L E V
20
+C P D C G G + V
19
K C P D C G G A L T F V
30
13.0%
NZ_CP096019.1:
Lanthipeptides: allorf_1444717_1444914_lanthipeptide
10
C P D C G G D V L E
19
C P+C G G +E
15
C P E C G G Y A I E
24

#### MIBiG 4.0 matches for EPL00_RS07765

8.7%
BGC0000582.4 (ADR72962.1):
Linaridin: cypemycin
24
P S V T E F V
30
P+V +F V
6
P T V A Q F V
12
allorf_1546009_1546125
Leader:
MSDFETYTCENCGDEFKAQESANAA
Core:
D E S Y C S P K C Q T A A
Core with dehydrations:
D E Dha Y Cys Dha P K Cys Q Dhb A A

#### antiSMASH-DB 4.0 matches for allorf_1546009_1546125

100.0%
NZ_ML974127.1:
Lanthipeptides: allorf_1546009_1546125_lanthipeptide
1
D E S Y C S P K C Q T A A
13
D E S Y C S P K C Q T A A
1
D E S Y C S P K C Q T A A
13
85.7%
NZ_CP096658.1:
Lanthipeptides: allorf_3178073_3178228_lanthipeptide
1
D E S Y C S P K C Q T A A
13
+E S Y C S P K C Q T A A
2
E E S Y C S P K C Q T A A
14
23.7%
NZ_CP119804.1:
Lanthipeptides: allorf_0774884_0775030_lanthipeptide
1
D E S Y C S P K C Q T A A
13
+ Y C S P K C Q T A
26
E N G Y C S P K C Q T T A
38
with 24 more sequence matches
Only the first 10 are displayed here.
23.3%
NZ_CP086322.1 and 1 other:
NZ_NDXL01000003.1 Lanthipeptides: B7024_RS31125_lanthipeptide
Lanthipeptides: K9S39_RS23570_lanthipeptide
3
S Y C S P K C Q T A A
13
S C+P C T A A
5
S L C T P G C V T A A
15
21.9%
NC_014479.1 and 9 others:
NZ_CP026362.1 Lanthipeptides: BV11031_RS00400_lanthipeptide NZ_CP033052.1 Lanthipeptides: D9779_RS17315_lanthipeptide NZ_CP051464.1 Lanthipeptides: HC660_RS17030_lanthipeptide NZ_JALAKK010000002.1 Lanthipeptides: MOB09_RS02800_lanthipeptide NZ_JALAKO010000014.1 Lanthipeptides: MOB26_RS08535_lanthipeptide NZ_JALAOG010000003.1 Lanthipeptides: MOC96_RS02500_lanthipeptide NZ_JALAPG010000043.1 Lanthipeptides: MOC70_RS16815_lanthipeptide NZ_JALAQI010000009.1 Lanthipeptides: MOD13_RS06065_lanthipeptide NZ_NXEM01000027.1 Lanthipeptides: CPT06_RS15285_lanthipeptide
Lanthipeptides: BSUW23_RS16845_lanthipeptide
1
D E S Y C S P K C Q T A A
13
E S C+P C T A
3
S E S L C T P G C V T G A
15
20.8%
NZ_CP007699.2 and 8 others:
NZ_CP048882.1 Lanthipeptides: G4Z16_RS06545_lanthipeptide NZ_CP048882.1 Lanthipeptides: G4Z16_RS06545_lanthipeptide NZ_FMHI01000015.1 Lanthipeptides: H180DRAFT_RS21560_lanthipeptide NZ_JADDUE010000020.1 Lanthipeptides: INP57_RS28495_lanthipeptide NZ_JAMTCQ010000009.1 Lanthipeptides: LY41_RS11610_lanthipeptide NZ_KB905819.1 Lanthipeptides: F603_RS34750_lanthipeptide NZ_LIVZ01000011.1 Lanthipeptides: AMK31_RS29125_lanthipeptide NZ_LIXJ01000007.1 Lanthipeptides: AMK22_RS13160_lanthipeptide
Lanthipeptides: T261_RS08380_lanthipeptide
3
S Y C S P K C Q T
11
S Y C+P C +
5
S Y C T P G C T S
13
20.7%
NZ_CP101621.1:
Lanthipeptides: NN913_RS16125_lanthipeptide
1
D E S Y C S P K C Q T A A
13
+S C+P C T A
3
S K S L C T P G C I T G A
15
20.0%
NZ_CP034587.1:
Lanthipeptides: EKH77_RS16870_lanthipeptide
3
S Y C S P K C Q T A A
13
S C+P C +A A
5
S L C T P G C P S A A
15
18.8%
NC_016047.1 and 2 others:
NZ_KZ848487.1 Lanthipeptides: DSL71_RS15965_lanthipeptide NZ_MUXL01000003.1 Lanthipeptides: B0W20_RS12275_lanthipeptide
Lanthipeptides: GYO_RS39160_lanthipeptide
1
D E S Y C S P K C Q T A
12
E S C+P C T
3
S E S V C T P G C V T G
14
18.8%
NZ_CP021903.1 and 20 others:
NZ_CP023409.1 Lanthipeptides: Bateq7PJ16_RS18530_lanthipeptide NZ_CP026036.1 Lanthipeptides: C2H93_RS15000_lanthipeptide NZ_CP028218.1 Lanthipeptides: C7M30_RS14555_lanthipeptide NZ_CP035167.1 Lanthipeptides: EQJ08_RS17140_lanthipeptide NZ_CP035226.1 Lanthipeptides: EQW70_RS18175_lanthipeptide NZ_CP045006.1 Lanthipeptides: F9B13_RS03875_lanthipeptide NZ_CP076083.1 Lanthipeptides: KFF76_RS16710_lanthipeptide NZ_CP079759.1 Lanthipeptides: KXZ66_RS17780_lanthipeptide NZ_CP080508.1 Lanthipeptides: K0V03_RS06525_lanthipeptide NZ_CP089148.1 Lanthipeptides: LRO88_RS19055_lanthipeptide NZ_JALAUA010000003.1 Lanthipeptides: MOD32_RS04985_lanthipeptide NZ_JALAVX010000009.1 Lanthipeptides: MOE40_RS09385_lanthipeptide NZ_JAMYDW010000007.1 Lanthipeptides: NHM07_RS16180_lanthipeptide NZ_JAQOXM010000001.1 Lanthipeptides: PO770_RS03875_lanthipeptide NZ_NJRD01000003.1 Lanthipeptides: CE053_RS07200_lanthipeptide NZ_NJRE01000008.1 Lanthipeptides: CE047_RS18435_lanthipeptide NZ_SORJ01000001.1 Lanthipeptides: BJ795_RS01490_lanthipeptide NZ_VFNF01000001.1 Lanthipeptides: FB592_RS01525_lanthipeptide NZ_VIOH01000001.1 Lanthipeptides: FLN47_RS03850_lanthipeptide NZ_VLJL01000012.1 Lanthipeptides: L604_RS09425_lanthipeptide
Lanthipeptides: CD007_RS17065_lanthipeptide
1
D E S Y C S P K C Q T A A
13
E S C+P C T
3
S E S L C T P G C V T G V
15
18.8%
NZ_CP025079.1 and 3 others:
NZ_CP047644.1 Lanthipeptides: GNE05_RS17275_lanthipeptide NZ_CP099859.1 Lanthipeptides: NIZ95_RS16280_lanthipeptide NZ_CP101621.1 Lanthipeptides: NN913_RS16115_lanthipeptide
Lanthipeptides: BVQ_RS17705_lanthipeptide
1
D E S Y C S P K C Q T A A
13
E S C+P C T
3
S E S V C T P G C V T G V
15
18.8%
NZ_CP059471.1 and 3 others:
NZ_FNZW01000001.1 Lanthipeptides: BMZ61_RS02110_lanthipeptide NZ_FOYC01000001.1 Lanthipeptides: BMZ88_RS03370_lanthipeptide NZ_KE384124.1 Lanthipeptides: G597_RS0106700_lanthipeptide
Lanthipeptides: H1R75_RS06635_lanthipeptide
1
D E S Y C S P K C Q T A A
13
+S C+P C+T A
3
S K S L C T P G C K T G A
15
18.2%
NZ_CP085954.1:
Lanthipeptides: LK411_RS13585_lanthipeptide
2
E S Y C S P K C Q T A A
13
+S C+P C T A
4
K S L C T P G C P T G A
15

#### MIBiG 4.0 matches for allorf_1546009_1546125

17.6%
BGC0000535.4 (ADJ56352.1):
Lanthipeptide: nisin A
3
S Y C S P K C Q T A A
13
S C+P C+T A
5
S L C T P G C K T G A
15
allorf_1566942_1567100
Leader:
MARGRGAARCCAGRSTPSSRHRGCSRWGLLSRHGS
Core:
R S R C D S W S W C D S W R A V R
Core with dehydrations:
R Dha R Cys D Dha W Dha W Cys D Dha W R A V R

#### antiSMASH-DB 4.0 matches for allorf_1566942_1567100

100.0%
NZ_ML974127.1:
Lanthipeptides: allorf_1566942_1567100_lanthipeptide
1
R S R C D S W S W C D S W R A V R
17
R S R C D S W S W C D S W R A V R
1
R S R C D S W S W C D S W R A V R
17
30.4%
NC_012470.1 and 5 others:
NZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS10335_lanthipeptide NZ_CP065058.1 Lanthipeptides: I2434_RS07250_lanthipeptide NZ_CP078012.1 Lanthipeptides: KV238_RS00510_lanthipeptide NZ_LS483328.1 Lanthipeptides: DQL47_RS07600_lanthipeptide NZ_LS483368.1 Lanthipeptides: DQM56_RS07295_lanthipeptide
Lanthipeptides: SZO_RS10195_lanthipeptide
1
R S R C D S W S W C D S W R A V
16
R S S W C +W A+
3
R F S T T S L S W C G N W S A I
18
allorf_1567150_1567224
Leader:
MSDYTKTRRALARPEVAAS
Core:
S S C E G
Core with dehydrations:
Dha Dha Cys E G

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
(Thi)azol(in)e containing peptide predictions
Lists the possible core peptides for each biosynthetic enzyme. Predicted tail sequences are also shown, if present.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.
No core peptides found.
Lanthipeptides
Azole RiPPs
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

EPL00_RS07765 - Class II
  Cleavage pHMM score: -5.60
  RODEO score: 0
  Monoisotopic mass: 5034.1 Da
  Molecular weight: 5037.4 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    5055.4 Da N = 1
    5073.4 Da N = 2
allorf_1546009_1546125 - Class II
  Cleavage pHMM score: -6.20
  RODEO score: 0
  Monoisotopic mass: 1347.6 Da
  Molecular weight: 1348.4 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1366.5 Da N = 1
allorf_1566942_1567100 - Class II
  Cleavage pHMM score: -6.60
  RODEO score: 0
  Monoisotopic mass: 2083.0 Da
  Molecular weight: 2084.3 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2102.3 Da N = 1
    2120.3 Da N = 2
allorf_1567150_1567224 - Class II
  Cleavage pHMM score: -7.00
  RODEO score: 0
  Monoisotopic mass: 445.1 Da
  Molecular weight: 445.4 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    463.5 Da N = 1

Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its possible molecular weights and the scores for cleavage site prediction and RODEO. If relevant, other features, such as macrocycle and amidation, will also be listed.
No core peptides found.
NZ_ML974127.1 - Region 7 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,573,391 - 1,585,202 nt. (total: 11,812 nt) Show pHMM detection rules used
Region on contig edge.
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
EPL00_RS07905: oxidoreductase

smcogs
  SMCOG1083: oxidoreductase

Ligases: synthetase
EPL00_RS07935: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.46 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.43 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.38 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0000677.5 |  | 0.37 | terpene | cyclooctatin | Streptomyces melanosporofaciens
BGC0001972.4 |  | 0.37 | other (other) | toxoflavin, fervenulin | Streptomyces hiroshimensis
BGC0002309.2 |  | 0.36 | terpene | cattleyene | Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000639.3 |  | 0.34 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0001911.3 |  | 0.34 | terpene | raimonol | Streptomyces anulatus
BGC0000642.3 |  | 0.33 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0001910.4 |  | 0.32 | terpene | cyslabdan A, cyslabdan B, cyslabdan C | Streptomyces cyslabdanicus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.46 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.43 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.38 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0000677.5 |  | 0.37 | terpene | cyclooctatin | Streptomyces melanosporofaciens
BGC0001972.4 |  | 0.37 | other (other) | toxoflavin, fervenulin | Streptomyces hiroshimensis
BGC0002309.2 |  | 0.36 | terpene | cattleyene | Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000639.3 |  | 0.34 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0001911.3 |  | 0.34 | terpene | raimonol | Streptomyces anulatus
BGC0000642.3 |  | 0.33 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0001910.4 |  | 0.32 | terpene | cyslabdan A, cyslabdan B, cyslabdan C | Streptomyces cyslabdanicus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP
diterpene precursor |  | GGPP | C20 | acyclic | PP
sesterterpene precursor |  | GFPP | C25 | acyclic | PP
triterpene precursor |  | HPP | C30 | acyclic | PP

Genes with terpene domains:
EPL00_RS07935: PT_FPPS_like
Domain 1 (40 - 351): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: unknown

Reactions:
  IPP, DMAPP → FPP
  IPP, DMAPP → GGPP
  IPP, DMAPP → GFPP
  IPP, DMAPP → HPP

Terpene
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
GFPP | Geranylfarnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
HPP | Hexaprenyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

NZ_ML974128.1 - Region 1 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 100,544 - 120,885 nt. (total: 20,342 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Isomerases: isomerase
EPL00_RS08555: isochorismate synthase

smcogs
  SMCOG1018: isochorismate synthase

Ligases: synthase
EPL00_RS08550: carbamoyl phosphate synthase small subunit

smcogs
  SMCOG1249: carbamoyl phosphate synthase small subunit

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001962.3 |  | 0.40 | PKS | hierridin B, hierridin C | Cyanobium sp. LEGE 06113
BGC0002031.3 |  | 0.39 | other (other) | kitasetaline | Kitasatospora setae KM-6054
BGC0001778.5 |  | 0.32 | other (other) | showdomycin | Streptomyces showdoensis
BGC0000514.5 |  | 0.32 | ribosomal | gallidermin | Staphylococcus gallinarum
BGC0000922.5 |  | 0.30 | PKS | 2-heptyl-3-hydroxy-4-quinolone, 2,4-Quinolinediol, 2-heptylquinolin-4(1H)-one | Pseudomonas aeruginosa PAO1
BGC0002324.3 |  | 0.29 | NRPS, PKS | myxochelin B, myxochelin N, myxochelin O, myxochelin P, myxochelin Q, myxochelin A | Archangium violaceum
BGC0001529.5 |  | 0.29 | other (other) | benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K | Streptomyces sp. RI18
BGC0002668.2 |  | 0.29 | ribosomal | cesin A | Clostridium estertheticum
BGC0002439.3 |  | 0.29 | other (other) | diastaphenazine, izumiphenazine C | Streptomyces diastaticus
BGC0002492.3 |  | 0.28 | NRPS | myxochelin B, myxochelin A | Myxococcus xanthus DK 1622

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001962.3 |  | 0.40 | PKS | hierridin B, hierridin C | Cyanobium sp. LEGE 06113
BGC0002031.3 |  | 0.39 | other (other) | kitasetaline | Kitasatospora setae KM-6054
BGC0001778.5 |  | 0.32 | other (other) | showdomycin | Streptomyces showdoensis
BGC0000514.5 |  | 0.32 | ribosomal | gallidermin | Staphylococcus gallinarum
BGC0000922.5 |  | 0.30 | PKS | 2-heptyl-3-hydroxy-4-quinolone, 2,4-Quinolinediol, 2-heptylquinolin-4(1H)-one | Pseudomonas aeruginosa PAO1
BGC0002324.3 |  | 0.29 | NRPS, PKS | myxochelin B, myxochelin N, myxochelin O, myxochelin P, myxochelin Q, myxochelin A | Archangium violaceum
BGC0001529.5 |  | 0.29 | other (other) | benzastatin J, 7-hydroxyl benzastatin B, 7-hydroxyl O-demethylbenzastatin A, JBIR-67, 7-hydroxyl benzastatin F, 7-hydroxyl O-demethylbenzastatin D, O-demethylvirantmycin, 7-hydroxyl benzastatin D, virantmycin, benzastatin K, methylbenzastatin K | Streptomyces sp. RI18
BGC0002668.2 |  | 0.29 | ribosomal | cesin A | Clostridium estertheticum
BGC0002439.3 |  | 0.29 | other (other) | diastaphenazine, izumiphenazine C | Streptomyces diastaticus
BGC0002492.3 |  | 0.28 | NRPS | myxochelin B, myxochelin A | Myxococcus xanthus DK 1622

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
tetraterpene | C40 carotenoid |  | C40 | unknown | unknown

Genes with terpene domains:
EPL00_RS08610: Lycopene_cycl
Domain 1 (12 - 91): Lycopene cyclase

Reactions:
  C40_carotenoid → C40_carotenoid

Terpene
Glossary
Glossary showing acronyms and their full names.
No acronyms to display
NZ_ML974128.1 - Region 2 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 355,327 - 367,147 nt. (total: 11,821 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: phosphatase
EPL00_RS09920: inositol monophosphatase

smcogs
  SMCOG1207: inositol monophosphatase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002584.2 |  | 0.45 | ribosomal | azolemycin B, azolemycin A, azolemycin D, azolemycin C | Streptomyces sp. FXJ1.264
BGC0000878.5 |  | 0.39 | other (other) | puromycin | Streptomyces alboniger
BGC0000249.5 |  | 0.29 | PKS | nogalamycin | Streptomyces nogalater
BGC0000716.5 |  | 0.28 | saccharide | spectinomycin | Streptomyces netropsis
BGC0002652.2 |  | 0.28 | other (other), saccharide | cytosaminomycin F, cytosaminomycin G, streptcytosine P, plicacetin, 40551-F, 12F-plicacetin, streptcytosine D, streptcytosine E | Streptomyces sp. SHP22-7
BGC0000715.5 |  | 0.28 | saccharide | actinospectacin | Streptomyces spectabilis
BGC0000873.3 |  | 0.25 | other (other) | A-201A | Saccharothrix mutabilis subsp. capreolus
BGC0000953.5 |  | 0.25 | saccharide | amicetin | Streptomyces vinaceusdrappus
BGC0002288.2 |  | 0.24 | NRPS | ashimide A, ashimide B | Streptomyces sp. NA03103
BGC0001138.5 |  | 0.24 | other (nucleoside) | a201a | Marinactinospora thermotolerans

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002584.2 |  | 0.45 | ribosomal | azolemycin B, azolemycin A, azolemycin D, azolemycin C | Streptomyces sp. FXJ1.264
BGC0000878.5 |  | 0.39 | other (other) | puromycin | Streptomyces alboniger
BGC0000249.5 |  | 0.29 | PKS | nogalamycin | Streptomyces nogalater
BGC0000716.5 |  | 0.28 | saccharide | spectinomycin | Streptomyces netropsis
BGC0002652.2 |  | 0.28 | other (other), saccharide | cytosaminomycin F, cytosaminomycin G, streptcytosine P, plicacetin, 40551-F, 12F-plicacetin, streptcytosine D, streptcytosine E | Streptomyces sp. SHP22-7
BGC0000715.5 |  | 0.28 | saccharide | actinospectacin | Streptomyces spectabilis
BGC0000873.3 |  | 0.25 | other (other) | A-201A | Saccharothrix mutabilis subsp. capreolus
BGC0000953.5 |  | 0.25 | saccharide | amicetin | Streptomyces vinaceusdrappus
BGC0002288.2 |  | 0.24 | NRPS | ashimide A, ashimide B | Streptomyces sp. NA03103
BGC0001138.5 |  | 0.24 | other (nucleoside) | a201a | Marinactinospora thermotolerans

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

NZ_SBIS02000007.1 - Region 1 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 22,163 - 45,384 nt. (total: 23,222 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: methyltransferase
EPL00_RS13675: methyltransferase

smcogs
  SMCOG1248: methyltransferase

Lyases: cyclase
EPL00_RS13700: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002703.2 |  | 0.50 | ribosomal | archalan α | Halorussus salinus
BGC0000525.5 |  | 0.50 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0002704.2 |  | 0.47 | ribosomal | archalan β | Halorussus salinus
BGC0002698.2 |  | 0.43 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0000517.4 |  | 0.41 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0002699.2 |  | 0.41 | ribosomal | nostolysamide A, nostolysamide B | Nostoc punctiforme PCC 73102
BGC0000486.4 |  | 0.40 | ribosomal | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0001222.3 |  | 0.39 | ribosomal | acidocin B | Lactobacillus acidophilus
BGC0000491.5 |  | 0.39 | ribosomal | gassericin A | Lactobacillus gasseri
BGC0001887.3 |  | 0.38 | ribosomal | huazacin | Bacillus thuringiensis serovar huazhongensis BGSC 4BD1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002703.2 |  | 0.50 | ribosomal | archalan α | Halorussus salinus
BGC0000525.5 |  | 0.50 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0002704.2 |  | 0.47 | ribosomal | archalan β | Halorussus salinus
BGC0002698.2 |  | 0.43 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0000517.4 |  | 0.41 | ribosomal | haloduracin β, haloduracin α | Bacillus halodurans C-125
BGC0002699.2 |  | 0.41 | ribosomal | nostolysamide A, nostolysamide B | Nostoc punctiforme PCC 73102
BGC0000486.4 |  | 0.40 | ribosomal | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0001222.3 |  | 0.39 | ribosomal | acidocin B | Lactobacillus acidophilus
BGC0000491.5 |  | 0.39 | ribosomal | gassericin A | Lactobacillus gasseri
BGC0001887.3 |  | 0.38 | ribosomal | huazacin | Bacillus thuringiensis serovar huazhongensis BGSC 4BD1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for EPL00_RS13700

EPL00_RS24065
Leader:
MSSDSLKDQIEAAYEQDERPVEAGTEQAG
Core:
Q M T V A F C G G H Y T N L E
Core with dehydrations:
Q M Dhb V A F Cys G G H Y Dhb N L E

#### antiSMASH-DB 4.0 matches for EPL00_RS24065

100.0%
NZ_SBIS02000007.1:
Lanthipeptides: EPL00_RS24065_lanthipeptide
1
Q M T V A F C G G H Y T N L E
15
Q M T V A F C G G H Y T N L E
1
Q M T V A F C G G H Y T N L E
15
25.0%
NZ_CP019893.1:
Lanthipeptides: B1756_RS19455_lanthipeptide
1
Q M T V A F C
7
M T+A F C
6
H M T I A F C
12
25.0%
NZ_JAKRKC020000001.1:
Lanthipeptides: MF672_RS25655_lanthipeptide
1
Q M T V A F C G G H
10
+T V A C G H
4
S L T V A T C G S H
13
EPL00_RS13710
Leader:
MKNEIRARRDAEGISQADLAAA
Core:
V G V T R Q T I N A I E R E R Y D P S I E L A F K L A D H F D C R I E D L F D P E L N G V G E G G
Core with dehydrations:
V G V Dhb R Q Dhb I N A I E R E R Y D P Dha I E L A F K L A D H F D Cys R I E D L F D P E L N G V G E G G

#### antiSMASH-DB 4.0 matches for EPL00_RS13710

100.0%
NZ_SBIS02000007.1:
Lanthipeptides: EPL00_RS13710_lanthipeptide
1
V G V T R Q T I N A I E R E R Y D P S I E L A F K L A D H F D C R I E D L F D P E L N G V G E G G
49
V G V T R Q T I N A I E R E R Y D P S I E L A F K L A D H F D C R I E D L F D P E L N G V G E G G
1
V G V T R Q T I N A I E R E R Y D P S I E L A F K L A D H F D C R I E D L F D P E L N G V G E G G
49
40.4%
NZ_NTSR01000029.1 and 1 other:
NZ_NTSR01000029.1 Lanthipeptides: CN358_RS25150_lanthipeptide
Lanthipeptides: CN358_RS25150_lanthipeptide
2
G V T R Q T I N A I E R E R Y D P S I E L A F K L A D H F D C R I E D L F D P
40
V+R Q T I N A I E ++Y D P S++L A F ++ + ++E D L F P
7
N V S R Q T I N A I E N K K Y D P S L Q L A F D I S K Q L E I K M E D L F L P
45
38.8%
NZ_QPJT01000003.1:
Lanthipeptides: DFR58_RS03990_lanthipeptide
4
T R Q T I N A I E R E R Y D P S I E L A F K L A D H F D C R I E D L F D
39
T R Q T I ++E E+Y S+ L A+K+A +F+ I E D+F D
1
T R Q T I T S L E C E K Y T A S L I L A Y K I A K Y F E T T I E D I F D
36
with 8 more sequence matches
34.7%
NZ_KN125582.1:
Lanthipeptides: DJ91_RS27555_lanthipeptide
4
T R Q T I N A I E R E R Y D P S I E L A F K L A D H F D C R I E D L F D
39
T R Q T I+A+E+ +Y P S+E L A F K+ + I+++F+
1
T R Q T I S A V E K N K Y S P S L E L A F K I C K V L E K S I D E V F E
36
33.3%
NZ_QICS01000003.1:
Lanthipeptides: C8E03_RS08720_lanthipeptide
1
V G V T R Q T I N A I E R E R Y D P S I E L A F K L A D H F D C R I E D L F
38
V V+ +T I +I E E+Y P S+ L A+++A+ F +E D L+
3
V N V S S R T I I S I E N E K Y K P S L I L A Y R I A E I F K V S M E D L Y
40
32.7%
NZ_NVMQ01000017.1:
Lanthipeptides: CON32_RS17800_lanthipeptide
4
T R Q T I N A I E R E R Y D P S I E L A F K L A D H F D C R I E D L F D
39
T R Q T I+A+E+ +Y P S++L A F++ F +E++F+
1
T R Q T I S A L E K N K Y T P S L D L A F R I C K I F G R T V E E V F E
36
26.5%
NZ_EQ973330.1 and 2 others:
NZ_LR134504.1 Lanthipeptides: EL293_RS07235_lanthipeptide NZ_LR134504.1 Lanthipeptides: EL293_RS07235_lanthipeptide
Lanthipeptides: CORMATOL_RS10555_lanthipeptide
1
V G V T R Q T I N A I E R E R Y D P-S I E L A F K L A D H F D C R I E D L F D P E
41
V G V T ++ ++ R L D D C+ D L F E
5
V G V T V A N L S V L K N N R A K A V R F T T L V A L C D A L D C Q P G D L F T A E
46
24.5%
NZ_QUCI01000001.1:
Lanthipeptides: DW648_RS00980_lanthipeptide
4
T R Q T I N A I E R E R Y D P S I E L A F K L A D H F D C R I E D L F
38
+R T+++I E +++P+ +L A L D + E+L F
1
S R N T V S S I E T G Q F N P T A K L A L V L C I A L D K K F E E L F
35
18.4%
NZ_QNRN01000010.1:
Lanthipeptides: DET63_RS17600_lanthipeptide
1
V G V T R Q T I N A I E R E R Y D P S I E L A F K L A D H F D C R I E D L F
38
V G++ T+ E + P + K L A+ + ++ +F
1
V G I S V S T L Q M Y E N G Q R I P R D N I K I K L A N F Y G V T V Q I I F
38
16.3%
NZ_CP034248.1:
Lanthipeptides: EIM92_RS23730_lanthipeptide
9
N A I E R E R Y D P S I E L A F K L A D H F D C R I E D L F D P E
41
N A+ +E R P + + K+ H + + E
11
N A L S Q E R I S P H V A I V N K V I S H M Q R T V V R I L A T E
43
12.2%
NZ_BLIS01000009.1 and 5 others:
NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04860_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02665_lanthipeptide NZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02665_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01890_lanthipeptide NZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01890_lanthipeptide
Lanthipeptides: GVO03_RS04860_lanthipeptide
17
D P S I E L A F K L A D H F D C R I E D L F D
39
+ + ++ K+ D C+I E D+ +
13
N V T T D I L L K I C I A L D C K I E D I I E
35

#### MIBiG 4.0 matches for EPL00_RS13710

8.2%
BGC0000503.5 (cinA):
Lanthipeptide: cinnamycin
32
C R I E D L F D P
40
C R F P
1
C R Q S C S F G P
9
allorf_035508_035597
Leader:
MSEIGRLRISAWG
Core:
S H L R C C R S R L T L R Y Y L
Core with dehydrations:
Dha H L R Cys Cys R Dha R L Dhb L R Y Y L

#### antiSMASH-DB 4.0 matches for allorf_035508_035597

100.0%
NZ_SBIS02000007.1:
Lanthipeptides: allorf_035508_035597_lanthipeptide
1
S H L R C C R S R L T L R Y Y L
16
S H L R C C R S R L T L R Y Y L
1
S H L R C C R S R L T L R Y Y L
16
23.3%
NZ_CP023465.1 and 1 other:
NZ_CP094357.1 Lanthipeptides: allorf_0702195_0702320_lanthipeptide
Lanthipeptides: allorf_0701083_0701208_lanthipeptide
1
S H L R C C R S R L T L R Y Y L
16
+H L R C R S + + Y
1
A H L R C A R S A M C V N C Y F
16
20.0%
NZ_CP011130.1 and 1 other:
NZ_KQ061218.1 Lanthipeptides: allorf_233227_233415_lanthipeptide
Lanthipeptides: allorf_0735524_0735712_lanthipeptide
1
S H L R C C R S R L T L R Y Y L
16
+H+R C R S + + Y
1
A H V R C A R S A M C V N C Y F
16

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Lanthipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

EPL00_RS24065 - Class II
  Cleavage pHMM score: -2.20
  RODEO score: 0
  Monoisotopic mass: 1633.7 Da
  Molecular weight: 1634.8 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1652.8 Da N = 1
EPL00_RS13710 - Class II
  Cleavage pHMM score: -3.50
  RODEO score: 0
  Monoisotopic mass: 5449.7 Da
  Molecular weight: 5453.0 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    5471.0 Da N = 1
    5489.0 Da N = 2
allorf_035508_035597 - Class II
  Cleavage pHMM score: -7.30
  RODEO score: 0
  Monoisotopic mass: 1985.1 Da
  Molecular weight: 1986.4 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2004.4 Da N = 1

NZ_SBIS02000007.1 - Region 2 - azole-containing-RiPP
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 354,479 - 378,801 nt. (total: 24,323 nt) Show pHMM detection rules used
azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Azole RiPPs
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | azole-containing-RiPP | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001174.4 |  | 0.49 | ribosomal | corynazolicin | Corynebacterium urealyticum DSM 7111
BGC0002013.4 |  | 0.47 | ribosomal | curacozole | Streptomyces curacoi
BGC0000916.5 |  | 0.44 | other (other) | molybdenum cofactor | Staphylococcus carnosus
BGC0000565.5 |  | 0.41 | ribosomal | goadsporin | Streptomyces sp. TP-A0584
BGC0000592.5 |  | 0.41 | ribosomal | microviridin B | Microcystis aeruginosa NIES-298
BGC0002049.3 |  | 0.40 | ribosomal | microviridin N9, microviridin N8, microviridin N7, microviridin N6, microviridin N5, microviridin N4, microviridin N3 | Nostoc punctiforme PCC 73102
BGC0000594.5 |  | 0.40 | ribosomal | microviridin K | Planktothrix agardhii NIVA-CYA 126/8
BGC0002656.2 |  | 0.37 | PKS | oryzanaphthopyran A, oryzanaphthopyran B, oryzanaphthopyran C, oryzanthrone A, oryzanthrone B, chlororyzanthrone A, chlororyzanthrone B | Streptacidiphilus oryzae TH49
BGC0001748.4 |  | 0.37 | NRPS, PKS | pseudospumigin A, pseudospumigin B, pseudospumigin C, pseudospumigin D, pseudospumigin E, pseudospumigin F | Nostoc sp. CENA543
BGC0001843.2 |  | 0.36 | NRPS | tridecaptin M | Paenibacillus sp. M-152

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001174.4 |  | 0.49 | ribosomal | corynazolicin | Corynebacterium urealyticum DSM 7111
BGC0002013.4 |  | 0.47 | ribosomal | curacozole | Streptomyces curacoi
BGC0000916.5 |  | 0.44 | other (other) | molybdenum cofactor | Staphylococcus carnosus
BGC0000565.5 |  | 0.41 | ribosomal | goadsporin | Streptomyces sp. TP-A0584
BGC0000592.5 |  | 0.41 | ribosomal | microviridin B | Microcystis aeruginosa NIES-298
BGC0002049.3 |  | 0.40 | ribosomal | microviridin N9, microviridin N8, microviridin N7, microviridin N6, microviridin N5, microviridin N4, microviridin N3 | Nostoc punctiforme PCC 73102
BGC0000594.5 |  | 0.40 | ribosomal | microviridin K | Planktothrix agardhii NIVA-CYA 126/8
BGC0002656.2 |  | 0.37 | PKS | oryzanaphthopyran A, oryzanaphthopyran B, oryzanaphthopyran C, oryzanthrone A, oryzanthrone B, chlororyzanthrone A, chlororyzanthrone B | Streptacidiphilus oryzae TH49
BGC0001748.4 |  | 0.37 | NRPS, PKS | pseudospumigin A, pseudospumigin B, pseudospumigin C, pseudospumigin D, pseudospumigin E, pseudospumigin F | Nostoc sp. CENA543
BGC0001843.2 |  | 0.36 | NRPS | tridecaptin M | Paenibacillus sp. M-152

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

(Thi)azol(in)e containing peptide predictions
Lists the possible core peptides for each biosynthetic enzyme. Predicted tail sequences are also shown, if present.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.
No core peptides found.
Azole RiPPs
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its possible molecular weights and the scores for cleavage site prediction and RODEO. If relevant, other features, such as macrocycle and amidation, will also be listed.
No core peptides found.
NZ_ML974129.1 - Region 1 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 208,496 - 229,578 nt. (total: 21,083 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
EPL00_RS12970: 3-hydroxybutyryl-CoA dehydrogenase

smcogs
  SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase

EPL00_RS12995: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

Hydrolases: hydrolase
EPL00_RS12960: isochorismatase

smcogs
  SMCOG1027: isochorismatase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000706.3 |  | 0.45 | saccharide | kanamycin | Streptomyces kanamyceticus
BGC0002284.3 |  | 0.42 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0001778.5 |  | 0.40 | other (other) | showdomycin | Streptomyces showdoensis
BGC0000207.5 |  | 0.37 | PKS | chartreusin | Streptomyces chartreusis
BGC0001464.3 |  | 0.35 | other (other) | tetrabromopyrrole | Pseudoalteromonas sp. PS5
BGC0001463.4 |  | 0.35 | other (other) | 2,3,4,5-tetrabromopyrrole | Pseudoalteromonas piscicida
BGC0002147.2 |  | 0.33 | NRPS | bohemamine A, bohemamine B, bohemamine C | Streptomyces sp. CB02009
BGC0000147.5 |  | 0.33 | PKS | soraphen A | Sorangium cellulosum
BGC0002091.3 |  | 0.32 | NRPS | holomycin | Yersinia ruckeri ATCC 29473
BGC0000679.5 |  | 0.32 | terpene | diazepinomicin | Micromonospora sp. M42

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000706.3 |  | 0.45 | saccharide | kanamycin | Streptomyces kanamyceticus
BGC0002284.3 |  | 0.42 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0001778.5 |  | 0.40 | other (other) | showdomycin | Streptomyces showdoensis
BGC0000207.5 |  | 0.37 | PKS | chartreusin | Streptomyces chartreusis
BGC0001464.3 |  | 0.35 | other (other) | tetrabromopyrrole | Pseudoalteromonas sp. PS5
BGC0001463.4 |  | 0.35 | other (other) | 2,3,4,5-tetrabromopyrrole | Pseudoalteromonas piscicida
BGC0002147.2 |  | 0.33 | NRPS | bohemamine A, bohemamine B, bohemamine C | Streptomyces sp. CB02009
BGC0000147.5 |  | 0.33 | PKS | soraphen A | Sorangium cellulosum
BGC0002091.3 |  | 0.32 | NRPS | holomycin | Yersinia ruckeri ATCC 29473
BGC0000679.5 |  | 0.32 | terpene | diazepinomicin | Micromonospora sp. M42

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene |  | squalene | C30 | acyclic | none
triterpene | C30 carotenoid | diapophytoene | C30 | acyclic | none
triterpene |  | PSPP | C30 | acyclic | PP
tetraterpene | C40 carotenoid | phytoene | C40 | acyclic | none
triterpene |  | hydroxysqualene | C30 | acyclic | OH

Genes with terpene domains:
EPL00_RS12980: PT_phytoene_like
Domain 1 (25 - 293): Prenyltransferase; Phytoene synthase like
Subtype: unknown

Reactions:
  FPP → squalene
  FPP → diapophytoene
  FPP → PSPP
  GGPP → phytoene
  PSPP → hydroxysqualene

Terpene
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
FPP | Farnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
PP | Diphosphate
PSPP | Presqualene diphosphate

NZ_SBIS02000011.1 - Region 1 - lanthipeptide-class-ii,terpene-precursor,triceptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 167,395 - 233,689 nt. (total: 66,295 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)
triceptide: ((cds(PF04055 and (TIGR04085 or SPASM)) and triceptide_precursor) or triceptide_rSAM)
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
Terpene
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
EPL00_RS20245: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: aminotransferase methyltransferase
EPL00_RS20345: methyltransferase

smcogs
  SMCOG1089: methyltransferase

EPL00_RS20525: aminotransferase class-III

smcogs
  SMCOG1013: aminotransferase class-III

Hydrolases: protease
EPL00_RS20405: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase
EPL00_RS20295: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

EPL00_RS20485: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Ligases: synthetase
EPL00_RS20420: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | triceptide | terpene-precursor | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | --- | ---
BGC0002704.2 |  |  |  |  | 1.16 | ribosomal | archalan β | Halorussus salinus
BGC0000601.4 |  |  |  |  | 0.39 | ribosomal | sporulation killing factor | Bacillus subtilis subsp. subtilis str. 168
BGC0002162.3 |  |  |  |  | 0.36 | terpene | sesterfisherol, sesterfisheric acid, compound 6, compound 7a, compound 5, compound 8 | Aspergillus fischeri NRRL 181
BGC0002736.2 |  |  |  |  | 0.36 | terpene | preaspterpenacid I | Aspergillus terreus NIH2624
BGC0002703.2 |  |  |  |  | 0.34 | ribosomal | archalan α | Halorussus salinus
BGC0000905.5 |  |  |  |  | 0.32 | other (other) | heme D1 | Heliobacillus mobilis
BGC0000906.3 |  |  |  |  | 0.32 | other (other) | heme D1 | Heliophilum fasciatum
BGC0000554.4 |  |  |  |  | 0.30 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000640.3 |  |  |  |  | 0.28 | terpene | carotenoid | Enterobacteriaceae bacterium DC404
BGC0001660.3 |  |  |  |  | 0.26 | ribosomal | mathermycin | Marinactinospora thermotolerans

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002704.2 |  | 1.00 | ribosomal | archalan β | Halorussus salinus
BGC0002703.2 |  | 0.51 | ribosomal | archalan α | Halorussus salinus
BGC0002162.3 |  | 0.50 | terpene | sesterfisherol, sesterfisheric acid, compound 6, compound 7a, compound 5, compound 8 | Aspergillus fischeri NRRL 181
BGC0001579.4 |  | 0.50 | ribosomal | duramycin | Streptomyces cinnamoneus
BGC0002736.2 |  | 0.50 | terpene | preaspterpenacid I | Aspergillus terreus NIH2624
BGC0000601.4 |  | 0.48 | ribosomal | sporulation killing factor | Bacillus subtilis subsp. subtilis str. 168
BGC0000503.5 |  | 0.48 | ribosomal | cinnamycin | Streptomyces cinnamoneus
BGC0000563.4 |  | 0.48 | ribosomal | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0000554.4 |  | 0.47 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0001226.4 |  | 0.47 | ribosomal | streptocollin | Streptomyces collinus Tu 365

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for EPL00_RS20295

allorf_171921_172073
Leader:
MNATRNRRRDAPRESRVCGA
Core:
G R Y G A R C C G G A V V I V V G G N E H R P T S S Q A S E
Core with dehydrations:
G R Y G A R Cys Cys G G A V V I V V G G N E H R P Dhb Dha Dha Q A Dha E

#### antiSMASH-DB 4.0 matches for allorf_171921_172073

100.0%
NZ_SBIS02000011.1:
Lanthipeptides: allorf_171921_172073_lanthipeptide
1
G R Y G A R C C G G A V V I V V G G N E H R P T S S Q A S E
30
G R Y G A R C C G G A V V I V V G G N E H R P T S S Q A S E
1
G R Y G A R C C G G A V V I V V G G N E H R P T S S Q A S E
30
23.3%
NZ_SNWQ01000001.1:
Lanthipeptides: EV643_RS00390_lanthipeptide
9
G G A V V I V V G G N E H R P T S
25
G G+ + V+G H R P++
3
G G S T L T V L G C G S H R P S N
19
20.0%
NZ_JACDUR010000003.1 and 1 other:
NZ_JACDUR010000003.1 Lanthipeptides: HNR30_RS17930_lanthipeptide
Lanthipeptides: HNR30_RS17930_lanthipeptide
9
G G A V V I V V G G N E H R P T S
25
G G+ + V+G N + P++
4
G G S T L T V L G C N S Y T P S N
20
with 4 more sequence matches
15.8%
NZ_CP073819.1:
Lanthipeptides: allorf_0065507_0065713_lanthipeptide
5
A R C C G G A V V I V V G G
18
+ C C G G+++ +G G
24
S N C C G G S L I C S L G G
37
15.8%
NZ_CP081833.1 and 1 other:
NZ_CP097053.1 Lanthipeptides: M2904_RS00460_lanthipeptide
Lanthipeptides: K5X77_RS00035_lanthipeptide
5
A R C C G G A V V I V V G G
18
+ C C G G+++ +G G
24
S N C C G G S I I C S L G G
37
15.8%
NZ_GG692670.1:
Lanthipeptides: EFKG_RS0103895_lanthipeptide
5
A R C C G G A V V I V V G G
18
+ C C G G+++ +G G
24
S N C C G G S L M C S L G G
37
10.9%
NZ_CP069338.1:
Lanthipeptides: allorf_07271223_07271444_lanthipeptide
19
N E H R P T S S Q A
28
+E H R P T S ++
12
D E H R P T S P E S
21
allorf_175166_175240
Leader:
MAILGG
Core:
V C S S K G L T F Y S Q R R G I G A
Core with dehydrations:
V Cys Dha Dha K G L Dhb F Y Dha Q R R G I G A

#### antiSMASH-DB 4.0 matches for allorf_175166_175240

100.0%
NZ_SBIS02000011.1:
Lanthipeptides: allorf_175166_175240_lanthipeptide
1
V C S S K G L T F Y S Q R R G I G A
18
V C S S K G L T F Y S Q R R G I G A
1
V C S S K G L T F Y S Q R R G I G A
18

#### Lanthipeptide(s) for EPL00_RS20485

allorf_226672_226833
Leader:
MGWNAEFRATNGG
Core:
C V S T V G F P P P V S S G V V L S Q H V R N L H K N I P S E T S S G H E T S R
Core with dehydrations:
Cys V Dha Dhb V G F P P P V Dha Dha G V V L Dha Q H V R N L H K N I P Dha E Dhb Dha Dha G H E Dhb Dha R

#### antiSMASH-DB 4.0 matches for allorf_226672_226833

100.0%
NZ_SBIS02000011.1:
Lanthipeptides: allorf_226672_226833_lanthipeptide
1
C V S T V G F P P P V S S G V V L S Q H V R N L H K N I P S E T S S G H E T S R
40
C V S T V G F P P P V S S G V V L S Q H V R N L H K N I P S E T S S G H E T S R
1
C V S T V G F P P P V S S G V V L S Q H V R N L H K N I P S E T S S G H E T S R
40
22.5%
NZ_CP113262.1:
Lanthipeptides: allorf_2442087_2442260_lanthipeptide
5
V G F P P P V S S G V V L S Q H V R N L H K
26
+G P S S G V V L + L +
14
L G Q P S G C S S G V V L E R A G E R L R R
35
18.6%
NZ_CP030771.1:
Lanthipeptides: allorf_09785478_09785648_lanthipeptide
11
V S S G V V L S Q H V R N L H K N I P S
30
V S G+V L+ H R + P+
11
V G S G I V L N D H F R K C W V S A P T
30
with 3 more sequence matches
13.0%
NZ_BJTV01000007.1:
Lanthipeptides: allorf_023321_023548_lanthipeptide
16
V L S Q H V R N L H K
26
V L S V R+L H+
10
V L S C W V R D L H R
20
12.5%
NZ_FOGM01000011.1:
Lanthipeptides: allorf_00061_00258_lanthipeptide
7
F P P P V S S G V V L S Q H V R
22
F P P P + +L H++
22
F P P P S R T T A I L V Y H L K
37
9.7%
NZ_CP102415.1:
Lanthipeptides: NQK81_RS00170_lanthipeptide
2
V S T V G F P P P V S S G V
15
S T+ F P +G V
2
A S T I A F A Q P A G A G V
15
allorf_228609_228767
Leader:
MIPAASLSADQPVAVALPTTAMTLETIIFP
Core:
I S I A A V G T N L D E G I Q K S C K F V E
Core with dehydrations:
I Dha I A A V G Dhb N L D E G I Q K Dha Cys K F V E

#### antiSMASH-DB 4.0 matches for allorf_228609_228767

100.0%
NZ_SBIS02000011.1:
Lanthipeptides: allorf_228609_228767_lanthipeptide
1
I S I A A V G T N L D E G I Q K S C K F V E
22
I S I A A V G T N L D E G I Q K S C K F V E
1
I S I A A V G T N L D E G I Q K S C K F V E
22
10.4%
NZ_KB905395.1 and 1 other:
NZ_KB905395.1 Lanthipeptides: allorf_13012_13248_lanthipeptide
Lanthipeptides: allorf_13012_13248_lanthipeptide
1
I S I A A V G T N L D E G I Q K S C K
19
+ +A +G N +G +C+
18
V P L A K L G C N T S D G C G H T C Q
36
allorf_228797_229003
Leader:
MVSNVTLGPLGMGVLAGA
Core:
E M I R T G L L S S N L P V A T V G V I I C G S S L V L G Y A V A R P R Q N K P N P D K G E N R T G
Core with dehydrations:
E M I R Dhb G L L Dha Dha N L P V A Dhb V G V I I Cys G Dha Dha L V L G Y A V A R P R Q N K P N P D K G E N R Dhb G

#### antiSMASH-DB 4.0 matches for allorf_228797_229003

100.0%
NZ_SBIS02000011.1:
Lanthipeptides: allorf_228797_229003_lanthipeptide
1
E M I R T G L L S S N L P V A T V G V I I C G S S L V L G Y A V A R P R Q N K P N P D K G E N R T G
50
E M I R T G L L S S N L P V A T V G V I I C G S S L V L G Y A V A R P R Q N K P N P D K G E N R T G
1
E M I R T G L L S S N L P V A T V G V I I C G S S L V L G Y A V A R P R Q N K P N P D K G E N R T G
50
20.0%
NZ_ADVG01000001.1:
Lanthipeptides: allorf_1943256_1943423_lanthipeptide
19
V I I C G S S L V L G Y A V A R P R Q N
38
V++C +S L G A R P R Q+
7
V V L C-A S L P H G D L Q A R P R Q D
25
18.0%
NZ_JANCLX010000003.1 and 1 other:
NZ_JANCLX010000003.1 Lanthipeptides: NMK44_RS06265_lanthipeptide
Lanthipeptides: NMK44_RS06265_lanthipeptide
12
L P V A T V G V I I C G S S L V L G Y A V
32
L P A ++C S S L+ G A+
1
L P D A A A A T V L C A S S L L C G S A L
21
with 1 more sequence matches
12.0%
NZ_CP026029.1:
Lassopeptides: C2I18_RS15915_lassopeptide
29
G Y A V A R P R Q N K P N
41
G+A+A Q N P+
3
G F A I A D S F Q N D P D
15
allorf_228993_229076
Leader:
METIVFS
Core:
S R H E G N Y P P C A L I V G G L A Y R
Core with dehydrations:
Dha R H E G N Y P P Cys A L I V G G L A Y R

#### antiSMASH-DB 4.0 matches for allorf_228993_229076

100.0%
NZ_SBIS02000011.1:
Lanthipeptides: allorf_228993_229076_lanthipeptide
1
S R H E G N Y P P C A L I V G G L A Y R
20
S R H E G N Y P P C A L I V G G L A Y R
1
S R H E G N Y P P C A L I V G G L A Y R
20
27.3%
NZ_BMNG01000001.1 and 1 other:
NZ_CP048641.1 Lassopeptides: G3H79_RS13380_lassopeptide
Lassopeptides: IEY91_RS02775_lassopeptide
1
S R H E G N Y P P C A L I V G
15
+R+E G +P P +G
6
A R Y E G G F P P Y E W Y L G
20
27.3%
NZ_CP040916.1:
Lassopeptides: FH965_RS40555_lassopeptide
1
S R H E G N Y P P C A L I V G
15
S +E G +P P +G
6
S Y Y E G G F P P Y E W Y L G
20
with 1 more sequence matches
22.7%
NZ_BNBL01000011.1:
Lassopeptides: IE295_RS25550_lassopeptide
1
S R H E G N Y P P C A L I V G
15
+++E G +P P +G
6
A Q Y E G G F P P Y E W Y L G
20
allorf_232870_232962
Leader:
MRRAFWRRTRNRFETFGRGYHYG
Core:
S H E V V C A
Core with dehydrations:
Dha H E V V Cys A

#### antiSMASH-DB 4.0 matches for allorf_232870_232962

100.0%
NZ_SBIS02000011.1:
Lanthipeptides: allorf_232870_232962_lanthipeptide
1
S H E V V C A
7
S H E V V C A
1
S H E V V C A
7
allorf_232888_233061
Leader:
MGTVVVPTAEGLEPITGS
Core:
P P E G S A H P S H Y L C V L A S G Q L V A E T V G R S N F D G K V G E S G A
Core with dehydrations:
P P E G Dha A H P Dha H Y L Cys V L A Dha G Q L V A E Dhb V G R Dha N F D G K V G E Dha G A

#### antiSMASH-DB 4.0 matches for allorf_232888_233061

100.0%
NZ_SBIS02000011.1:
Lanthipeptides: allorf_232888_233061_lanthipeptide
1
P P E G S A H P S H Y L C V L A S G Q L V A E T V G R S N F D G K V G E S G A
39
P P E G S A H P S H Y L C V L A S G Q L V A E T V G R S N F D G K V G E S G A
1
P P E G S A H P S H Y L C V L A S G Q L V A E T V G R S N F D G K V G E S G A
39
23.1%
NZ_MCIF01000002.1:
Lanthipeptides: allorf_2097064_2097252_lanthipeptide
1
P P E G S A H P S H Y--L C V L A
16
P P +A H P S L C+L+
11
P P P S T A H P S S I S A L C L L S
28
15.4%
NZ_KV917376.1:
Lassopeptides: BK582_RS26540_lassopeptide
27
R S N F D G K V G E S G A
39
+N F D G K+ ++ A
3
N A N F D G K I N K A C A
15

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP
diterpene precursor |  | GGPP | C20 | acyclic | PP
sesterterpene precursor |  | GFPP | C25 | acyclic | PP
triterpene precursor |  | HPP | C30 | acyclic | PP

Genes with terpene domains:
EPL00_RS20420: PT_FPPS_like
Domain 1 (28 - 256): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: unknown

Reactions:
  IPP, DMAPP → FPP
  IPP, DMAPP → GGPP
  IPP, DMAPP → GFPP
  IPP, DMAPP → HPP

Lanthipeptides
Terpene
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

allorf_171921_172073 - Class II
  Cleavage pHMM score: -4.80
  RODEO score: 0
  Monoisotopic mass: 2944.4 Da
  Molecular weight: 2946.2 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2964.2 Da N = 1
    2982.3 Da N = 2
allorf_175166_175240 - Class II
  Cleavage pHMM score: -6.40
  RODEO score: 0
  Monoisotopic mass: 1857.0 Da
  Molecular weight: 1858.1 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1876.1 Da N = 1
    1894.2 Da N = 2
    1912.2 Da N = 3
allorf_226672_226833 - Class II
  Cleavage pHMM score: -3.90
  RODEO score: 0
  Monoisotopic mass: 4028.1 Da
  Molecular weight: 4030.4 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4048.5 Da N = 1
    4066.5 Da N = 2
    4084.5 Da N = 3
    4102.5 Da N = 4
    4120.5 Da N = 5
    4138.6 Da N = 6
    4156.6 Da N = 7
    4174.6 Da N = 8
    4192.6 Da N = 9
    4210.6 Da N = 10
allorf_228609_228767 - Class II
  Cleavage pHMM score: -6.60
  RODEO score: 0
  Monoisotopic mass: 2267.2 Da
  Molecular weight: 2268.6 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2286.6 Da N = 1
    2304.6 Da N = 2
allorf_228797_229003 - Class II
  Cleavage pHMM score: -1.40
  RODEO score: 0
  Monoisotopic mass: 5121.8 Da
  Molecular weight: 5124.9 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    5142.9 Da N = 1
    5160.9 Da N = 2
    5178.9 Da N = 3
    5196.9 Da N = 4
    5215.0 Da N = 5
    5233.0 Da N = 6
allorf_228993_229076 - Class II
  Cleavage pHMM score: -7.00
  RODEO score: 0
  Monoisotopic mass: 2154.1 Da
  Molecular weight: 2155.4 Da
  Number of bridges: 1
allorf_232870_232962 - Class II
  Cleavage pHMM score: -7.00
  RODEO score: 0
  Monoisotopic mass: 725.3 Da
  Molecular weight: 725.8 Da
  Number of bridges: 1
allorf_232888_233061 - Class II
  Cleavage pHMM score: -4.20
  RODEO score: 0
  Monoisotopic mass: 3814.9 Da
  Molecular weight: 3817.1 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3835.2 Da N = 1
    3853.2 Da N = 2
    3871.2 Da N = 3
    3889.2 Da N = 4
    3907.2 Da N = 5

Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
GFPP | Geranylfarnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
HPP | Hexaprenyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate