GCF_004375095.1 - 11 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_SNUX01000001.1 (Shouchella lehensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	terpene-precursor	530,773	551,657

NZ_SNUX01000002.1 (Shouchella lehensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 2.1	ectoine	292,784	303,179	Medium	ectoine	other:other
Region 2.2	NRPS,NRPS-like,T1PKS,terpene-precursor	339,423	395,253
Region 2.3	lanthipeptide-class-iii	440,215	462,833	High	andalusicin A/andalusicin B	ribosomal:RiPP:Lanthipeptide
Region 2.4	NRPS-like,terpene	490,139	537,490
Region 2.5	terpene	635,050	655,970

NZ_SNUX01000003.1 (Shouchella lehensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 3.1	T3PKS	15,539	56,639
Region 3.2	terpene,t3nrps-iterative,NI-siderophore	607,068	686,555	Low	carotenoid	terpene
Region 3.3	glycocin	805,069	825,287

NZ_SNUX01000004.1 (Shouchella lehensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 4.1	terpene	444,520	466,403
Region 4.2	terpene	687,118	708,908	Low	bacillomycin D	NRPS:Type I+PKS

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	terpene-precursor	530,773	551,657
Region 2.1	ectoine	292,784	303,179	Medium	ectoine	other:other
Region 2.2	NRPS,NRPS-like,T1PKS,terpene-precursor	339,423	395,253
Region 2.3	lanthipeptide-class-iii	440,215	462,833	High	andalusicin A/andalusicin B	ribosomal:RiPP:Lanthipeptide
Region 2.4	NRPS-like,terpene	490,139	537,490
Region 2.5	terpene	635,050	655,970
Region 3.1	T3PKS	15,539	56,639
Region 3.2	terpene,t3nrps-iterative,NI-siderophore	607,068	686,555	Low	carotenoid	terpene
Region 3.3	glycocin	805,069	825,287
Region 4.1	terpene	444,520	466,403
Region 4.2	terpene	687,118	708,908	Low	bacillomycin D	NRPS:Type I+PKS

No secondary metabolite regions were found in these records:: NZ_SNUX01000005.1 (Shouchella lehensis); NZ_SNUX01000006.1 (Shouchella lehensis); NZ_SNUX01000007.1 (Shouchella lehensis); NZ_SNUX01000008.1 (Shouchella lehensis)

Compact view

NZ_SNUX01000001.1 - Region 1 - terpene-precursor

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Location: 530,773 - 551,657 nt. (total: 20,885 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

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core biosynthetic genes

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Gene overview

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KnownClusterBlast

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Terpene

TFBS Finder

Gene/CDS overview

Filter:

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: carboxylase

E2L03_RS02795: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase

E2L03_RS02765: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

E2L03_RS02770: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000665.5	0.38	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0000668.5	0.37	other (other), terpene	12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole	Hapalosiphon welwitschii UTEX B 1830

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000665.5	0.38	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0000668.5	0.37	other (other), terpene	12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole	Hapalosiphon welwitschii UTEX B 1830

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

E2L03_RS02770: PT_FPPS_like

Domain 1 (33 - 293): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.15 out of 26.06

Confidence: medium

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.21 out of 25.88

Confidence: medium

Additional weak hits (2):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.64 out of 30.25

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.89 out of 30.25

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
MogR	Repressor of flagellar motility genes
PsrA	Oleic acid responsive regulator

NZ_SNUX01000002.1 - Region 1 - ectoine

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Location: 292,784 - 303,179 nt. (total: 10,396 nt) Show pHMM detection rules used

ectoine: ectoine_synt

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

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MIBiG comparison

KnownClusterBlast

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TFBS Finder

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: aminotransferase

E2L03_RS07615: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000858.3	0.73	other (other)	ectoine	Methylobacter marinus
BGC0000855.3	0.72	other (other)	ectoine	Methylomicrobium kenyense
BGC0000856.3	0.72	other (other)	ectoine	Methylophaga thalassica
BGC0000852.5	0.71	other (other)	ectoine	Sporosarcina pasteurii
BGC0000859.3	0.66	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0000857.3	0.64	other (other)	ectoine	Methylophaga alcalica
BGC0000853.3	0.58	other (other)	ectoine	Streptomyces anulatus
BGC0002052.3	0.58	other (ectoine)	ectoine	Streptomyces sp.
BGC0000854.3	0.52	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z
BGC0000860.3	0.51	other (other)	ectoine	Methylarcula marina

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000858.3	0.73	other (other)	ectoine	Methylobacter marinus
BGC0000855.3	0.72	other (other)	ectoine	Methylomicrobium kenyense
BGC0000856.3	0.72	other (other)	ectoine	Methylophaga thalassica
BGC0000852.5	0.71	other (other)	ectoine	Sporosarcina pasteurii
BGC0000859.3	0.66	other (other)	ectoine	Methylomicrobium alcaliphilum
BGC0000857.3	0.64	other (other)	ectoine	Methylophaga alcalica
BGC0000853.3	0.58	other (other)	ectoine	Streptomyces anulatus
BGC0002052.3	0.58	other (ectoine)	ectoine	Streptomyces sp.
BGC0000854.3	0.52	other (other)	ectoine	Methylomicrobium alcaliphilum 20Z
BGC0000860.3	0.51	other (other)	ectoine	Methylarcula marina

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.31 out of 26.06

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.11 out of 27.55

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.25 out of 20.97

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.11 out of 26.06

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.52 out of 28.19

Confidence: medium

TFBS Finder

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
GnfM	Regulator of nitrogen-fixation genes
MogR	Repressor of flagellar motility genes
ZuR variant 1	Zinc-responsive repressor

NZ_SNUX01000002.1 - Region 2 - NRPS,NRPS-like,T1PKS,terpene-precursor

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Location: 339,423 - 395,253 nt. (total: 55,831 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: PPTase acetyltransferase acylase methyltransferase

E2L03_RS07815: methyltransferase

smcogs: SMCOG1089: methyltransferase

E2L03_RS07880: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

E2L03_RS07965: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

E2L03_RS07975: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: hydrolase

E2L03_RS07875: amidohydrolase

smcogs: SMCOG1244: amidohydrolase

Ligases: ligase

E2L03_RS07930: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

E2L03_RS07940: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Translocases: transport

E2L03_RS07950: MMPL domain-containing transport protein

smcogs: SMCOG1035: MMPL domain-containing transport protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001164.3	1.01	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001244.3	0.95	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0002192.3	0.89	PKS	FR901512	fungal sp. No.14919
BGC0001250.4	0.86	NRPS	epichloenin A	Epichloe festucae
BGC0001268.4	0.84	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0001284.4	0.84	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001254.3	0.82	PKS	ACT-Toxin II	Alternaria alternata
BGC0001160.5	0.79	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0000107.3	0.78	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001257.3	0.78	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001244.3	0.65	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0002192.3	0.63	PKS	FR901512	fungal sp. No.14919
BGC0001250.4	0.62	NRPS	epichloenin A	Epichloe festucae
BGC0001268.4	0.62	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0001284.4	0.62	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001254.3	0.61	PKS	ACT-Toxin II	Alternaria alternata
BGC0001164.3	0.60	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.60	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0000107.3	0.59	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001257.3	0.59	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

E2L03_RS07980: PT_FPPS_like

Domain 1 (88 - 279): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.28 out of 20.01

Confidence: medium

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 27.28 out of 32.93

Confidence: medium

Additional weak hits (7):

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 22.09 out of 30.11

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 23.18 out of 30.11

Confidence: weak

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 25.30 out of 32.38

Confidence: weak

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 20.20 out of 32.38

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 22.94 out of 32.93

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.61 out of 27.04

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Terpene

TFBS Finder

Predicted core structure(s)

For candidate cluster 2, location 339422 - 395253:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (fatty_acid - ohmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 339422 - 385008:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (fatty_acid - ohmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 346166 - 395253:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (fatty_acid - ohmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

E2L03_RS07930: Ser

Search NORINE for peptide: strict or relaxed

AMP-binding (664..1069): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWHTFDVSVWEWHFLFSGEANLYGPTEASIDVTC
Nearest Stachelhaus code(s):: Ser DVWHLSLIDK (85% 8Å match)
Stachelhaus code match:: 100% (strong)

E2L03_RS07940: fatty_acid - mal

CAL_domain (181..495): fatty_acid

minowa: fatty_acid

Prediction, score:

fatty_acid: 73.3
NH2: 36.1
Acetyl-CoA: 7.8
shikimic_acid: 0.0
AHBA: 0.0

PKS_AT (1254..1543): mal

ATSignature: Malonyl-CoA, inactive

Top 3 matches:: Malonyl-CoA: 79.2%; inactive: 79.2%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 119.2
inactive: 103.5
Methoxymalonyl-CoA: 60.9
Methylmalonyl-CoA: 56.0
Propionyl-CoA: 31.4
Ethylmalonyl-CoA: 27.2
2-Methylbutyryl-CoA: 19.6
Benzoyl-CoA: 14.6
Acetyl-CoA: 9.7
Isobutyryl-CoA: 9.3
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

E2L03_RS07965: mxmal

PKS_AT (7..294): mxmal

ATSignature: (unknown)

No matches above 50%

minowa: Methoxymalonyl-CoA

Prediction, score:

Methoxymalonyl-CoA: 23.0
Methylmalonyl-CoA: 12.8
Malonyl-CoA: 9.7
Isobutyryl-CoA: 8.7
trans-1,2-CPDA: 0.0
inactive: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
ArgR	Regulator of arginine biosynthesis genes
RicR	Copper-responsive regulator
ToxT	Regulator of MSHA biosynthesis

NZ_SNUX01000002.1 - Region 3 - lanthipeptide-class-iii

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Location: 440,215 - 462,833 nt. (total: 22,619 nt) Show pHMM detection rules used

lanthipeptide-class-iii: (micKC and not PKS_KS)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: methyltransferase

E2L03_RS08365: methyltransferase

smcogs: SMCOG1248: methyltransferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002700.2	0.73	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0002111.3	0.59	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0000551.5	0.53	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000519.4	0.51	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000496.5	0.50	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000513.3	0.50	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000518.3	0.49	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0000553.3	0.48	ribosomal	SRO15-2212	Streptomyces filamentosus NRRL 15998
BGC0002701.2	0.47	ribosomal	paenithipeptin	Paenibacillus thiaminolyticus
BGC0001210.5	0.44	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002700.2	0.73	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0002111.3	0.59	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0000551.5	0.53	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000519.4	0.51	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000496.5	0.50	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000513.3	0.50	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000518.3	0.49	ribosomal	informatipeptin	Streptomyces viridochromogenes DSM 40736
BGC0000553.3	0.48	ribosomal	SRO15-2212	Streptomyces filamentosus NRRL 15998
BGC0002701.2	0.47	ribosomal	paenithipeptin	Paenibacillus thiaminolyticus
BGC0001210.5	0.44	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for E2L03_RS08360

E2L03_RS20335

Leader:

MNQVLELQKLAHEVD

E2L03_RS20350

Leader:

MNQVLDLQKLAHEVD

Shared core:

GQGQWSVEKSPATVTITTTAVGWSTASNDC

Core with dehydrations:

GQGQWDhaVEKDhaPADhbVDhbIDhbDhbDhbAVGWDhaDhbADhaNDCys

antiSMASH-DB 4.0 matches for E2L03_RS20335

100.0%

NZ_CP003923.1and 3 others:

NZ_KV917380.1 Lanthipeptides: BK583_RS20910_lanthipeptideNZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20350_lanthipeptideNZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20335_lanthipeptide

Lanthipeptides: BLEG1_RS21165_lanthipeptide

1

GQGQWSVEKSPATVTITTTAVGWSTASNDC

30

GQGQWSVEKSPATVTITTTAVGWSTASNDC

1

GQGQWSVEKSPATVTITTTAVGWSTASNDC

30

90.0%

NZ_CP042163.1and 1 other:

NZ_CP117834.1 Lanthipeptides: PQ477_RS10645_lanthipeptide

Lanthipeptides: FPV17_RS21690_lanthipeptide

1

GQGQWSVEKSPATVTITTTAVGWSTASNDC

30

GQGQWSVEKSPAT+T TTTAVGWSTASN C

1

GQGQWSVEKSPATITTTTTAVGWSTASNGC

30

86.7%

NZ_CP003923.1and 9 others:

NZ_CP042163.1 Lanthipeptides: FPV17_RS21700_lanthipeptideNZ_CP042163.1 Lanthipeptides: FPV17_RS21695_lanthipeptideNZ_CP042163.1 Lanthipeptides: FPV17_RS21680_lanthipeptideNZ_CP117834.1 Lanthipeptides: PQ477_RS10655_lanthipeptideNZ_CP117834.1 Lanthipeptides: PQ477_RS10650_lanthipeptideNZ_CP117834.1 Lanthipeptides: PQ477_RS10635_lanthipeptideNZ_KV917380.1 Lanthipeptides: BK583_RS20895_lanthipeptideNZ_KV917380.1 Lanthipeptides: BK583_RS20890_lanthipeptideNZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20355_lanthipeptide

Lanthipeptides: BLEG1_RS21185_lanthipeptide

5

WSVEKSPATVTITTTAVGWSTASNDC

30

WSVEKSPATVTITTTAVGWSTASNDC

1

WSVEKSPATVTITTTAVGWSTASNDC

26

with 6 more sequence matches

76.7%

NZ_CP003923.1and 2 others:

NZ_KV917380.1 Lanthipeptides: BK583_RS20900_lanthipeptideNZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20345_lanthipeptide

Lanthipeptides: BLEG1_RS21175_lanthipeptide

5

WSVEKSPATVTITTTAVGWSTASNDC

30

WSVEKSPAT+T TTTAVGWSTASN C

1

WSVEKSPATITTTTTAVGWSTASNGC

26

66.7%

NZ_CP003923.1and 4 others:

NZ_CP042163.1 Lanthipeptides: FPV17_RS21685_lanthipeptideNZ_CP117834.1 Lanthipeptides: PQ477_RS10640_lanthipeptideNZ_KV917380.1 Lanthipeptides: BK583_RS20905_lanthipeptideNZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20340_lanthipeptide

Lanthipeptides: BLEG1_RS21170_lanthipeptide

5

WSVEKSPATVTITTTAVGWSTASNDC

30

WSVEKSPAT+T T T +GWSTASN C

1

WSVEKSPATITTTRTVIGWSTASNSC

26

40.0%

NZ_CP066711.1:

Lanthipeptides: allorf_1652598_1652744_lanthipeptide

12

ATVTITTTAVGWSTASNDC

30

ATV IT T G ST SN C

7

ATVEITMTVYGLSTISNKC

25

23.3%

NZ_SMBT01000005.1:

Lanthipeptides: EV682_RS11315_lanthipeptide

19

TAVGWSTASNDC

30

T WST SN C

1

TPADWSTVSNHC

12

20.0%

NZ_CP113837.1and 1 other:

NZ_CP113837.1 Lanthipeptides: OU787_RS28895_lanthipeptide

Lanthipeptides: OU787_RS28905_lanthipeptide

23

WSTASNDC

30

WST SN C

1

WSTVSNHC

8

20.0%

NZ_FOHE01000012.1:

Lanthipeptides: BMX40_RS20340_lanthipeptide

23

WSTASNDC

30

WST SN+C

18

WSTVSNNC

25

MIBiG 4.0 matches for E2L03_RS20335

23.3%

BGC0002130.3 (QKI29070.1):

Lanthipeptide: cacaoidin

8

EKSPATVTITTTAVGWSTASNDC

30

+P T+ + +A +TAS C

1

SSAPCTIYASVSASISATASWGC

23

20.0%

BGC0002111.3 (multiple genes):

Lanthipeptide: andalusicin A or andalusicin B

21

VGWSTASNDC

30

V ST SN+C

14

VWASTISNNC

23

13.3%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

22

GWSTASNDC

30

GW T + +C

17

GWCTLTKEC

25

E2L03_RS20340

Leader:

MNQVLELQKLAHDSDGQEQ

Core:

WSVEKSPATITTTRTVIGWSTASNSC

Core with dehydrations:

WDhaVEKDhaPADhbIDhbDhbDhbRDhbVIGWDhaDhbADhaNDhaCys

antiSMASH-DB 4.0 matches for E2L03_RS20340

100.0%

NZ_CP003923.1and 4 others:

NZ_CP042163.1 Lanthipeptides: FPV17_RS21685_lanthipeptideNZ_CP117834.1 Lanthipeptides: PQ477_RS10640_lanthipeptideNZ_KV917380.1 Lanthipeptides: BK583_RS20905_lanthipeptideNZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20340_lanthipeptide

Lanthipeptides: BLEG1_RS21170_lanthipeptide

1

WSVEKSPATITTTRTVIGWSTASNSC

26

WSVEKSPATITTTRTVIGWSTASNSC

1

WSVEKSPATITTTRTVIGWSTASNSC

26

84.6%

NZ_CP003923.1and 4 others:

NZ_CP042163.1 Lanthipeptides: FPV17_RS21690_lanthipeptideNZ_CP117834.1 Lanthipeptides: PQ477_RS10645_lanthipeptideNZ_KV917380.1 Lanthipeptides: BK583_RS20900_lanthipeptideNZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20345_lanthipeptide

Lanthipeptides: BLEG1_RS21175_lanthipeptide

1

WSVEKSPATITTTRTVIGWSTASNSC

26

WSVEKSPATITTT T +GWSTASN C

1

WSVEKSPATITTTTTAVGWSTASNGC

26

66.7%

NZ_CP003923.1and 13 others:

NZ_CP003923.1 Lanthipeptides: BLEG1_RS21185_lanthipeptideNZ_CP042163.1 Lanthipeptides: FPV17_RS21700_lanthipeptideNZ_CP042163.1 Lanthipeptides: FPV17_RS21695_lanthipeptideNZ_CP042163.1 Lanthipeptides: FPV17_RS21680_lanthipeptideNZ_CP117834.1 Lanthipeptides: PQ477_RS10655_lanthipeptideNZ_CP117834.1 Lanthipeptides: PQ477_RS10650_lanthipeptideNZ_CP117834.1 Lanthipeptides: PQ477_RS10635_lanthipeptideNZ_KV917380.1 Lanthipeptides: BK583_RS20910_lanthipeptideNZ_KV917380.1 Lanthipeptides: BK583_RS20895_lanthipeptideNZ_KV917380.1 Lanthipeptides: BK583_RS20890_lanthipeptideNZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20350_lanthipeptideNZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20335_lanthipeptideNZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20355_lanthipeptide

Lanthipeptides: BLEG1_RS21165_lanthipeptide

1

WSVEKSPATITTTRTVIGWSTASNSC

26

WSVEKSPAT+T T T +GWSTASN C

5

WSVEKSPATVTITTTAVGWSTASNDC

30

with 12 more sequence matches

Only the first 10 are displayed here.

36.7%

NZ_CP066711.1:

Lanthipeptides: allorf_1652598_1652744_lanthipeptide

8

ATITTTRTVIGWSTASNSC

26

AT+ T TV G ST SN C

7

ATVEITMTVYGLSTISNKC

25

34.6%

NC_014551.1and 27 others:

NC_014551.1 Lanthipeptides: BAMF_RS41675_lanthipeptideNC_014551.1 Lanthipeptides: BAMF_RS41665_lanthipeptideNC_017188.1 Lanthipeptides: BAMTA208_RS20945_lanthipeptideNC_017188.1 Lanthipeptides: BAMTA208_RS20950_lanthipeptideNC_017188.1 Lanthipeptides: BAMTA208_RS20940_lanthipeptideNZ_CP026010.1 Lanthipeptides: BS11774_RS22090_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20770_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20775_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20765_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21840_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21835_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04865_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04860_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03885_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03890_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03880_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19010_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19005_lanthipeptideNZ_DF836084.1 Lanthipeptides: CMW1_RS20380_lanthipeptideNZ_DF836084.1 Lanthipeptides: CMW1_RS20385_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18880_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18875_lanthipeptideNZ_JALAUK010000033.1 Lanthipeptides: MOE38_RS18580_lanthipeptideNZ_JALAVZ010000001.1 Lanthipeptides: MOF00_RS00405_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19500_lanthipeptideNZ_KQ236689.1 Lanthipeptides: AD710_RS19860_lanthipeptideNZ_KQ236689.1 Lanthipeptides: AD710_RS19855_lanthipeptide

Lanthipeptides: BAMF_RS41670_lanthipeptide

10

ITTTRTVIGWSTASNSC

26

+T TV+G ST SN+C

2

LTLITTVVGTSTISNNC

18

34.6%

NC_014551.1and 13 others:

NC_017188.1 Lanthipeptides: BAMTA208_RS20935_lanthipeptideNZ_CP026010.1 Lanthipeptides: BS11774_RS22080_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20760_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21830_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04855_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03875_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19015_lanthipeptideNZ_DF836084.1 Lanthipeptides: CMW1_RS20390_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21915_lanthipeptideNZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19785_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18870_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19495_lanthipeptideNZ_KQ236689.1 Lanthipeptides: AD710_RS19845_lanthipeptide

Lanthipeptides: BAMF_RS41660_lanthipeptide

15

TVIGWSTASNSC

26

T+IG ST SNSC

9

TLIGTSTISNSC

20

34.5%

NZ_FOHE01000012.1:

Lanthipeptides: BMX40_RS20340_lanthipeptide

9

TITTTRTVI--GWSTASNSC

26

TITT ++ WST SN+C

6

TITTVSAILTTFWSTVSNNC

25

30.8%

NC_014551.1and 5 others:

NC_017188.1 Lanthipeptides: BAMTA208_RS20930_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20755_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03870_lanthipeptideNZ_DF836084.1 Lanthipeptides: CMW1_RS20395_lanthipeptideNZ_KQ236689.1 Lanthipeptides: AD710_RS19840_lanthipeptide

Lanthipeptides: BAMF_RS41655_lanthipeptide

10

ITTTRTVIGWSTASNSC

26

+T T++G ST SN+C

2

LTLITTIVGSSTISNNC

18

30.8%

NZ_CP026010.1and 18 others:

NZ_CP026010.1 Lanthipeptides: BS11774_RS22085_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21825_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21845_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04850_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04870_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19020_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19000_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21910_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21930_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21925_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21920_lanthipeptideNZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19790_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18865_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18885_lanthipeptideNZ_JALAVZ010000001.1 Lanthipeptides: MOF00_RS00410_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19490_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19510_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19505_lanthipeptide

Lanthipeptides: BS11774_RS22075_lanthipeptide

10

ITTTRTVIGWSTASNSC

26

+T T++G ST SN+C

2

LTLITTIVGTSTISNNC

18

30.8%

NZ_LN868937.1and 1 other:

NZ_LN868937.1 Lanthipeptides: BN2144_RS20095_lanthipeptide

Lanthipeptides: BN2144_RS20100_lanthipeptide

15

TVIGWSTASNSC

26

T+IG ST SN+C

10

TLIGTSTISNNC

21

28.6%

NZ_FTML01000041.1:

Lanthipeptides: BW937_RS20035_lanthipeptide

4

EKSPATITTTRTVIG

18

E SPA + T VIG

6

ETSPACLYTGGVVIG

20

26.9%

NZ_CP014222.1:

Lanthipeptides: VN23_RS10390_lanthipeptide

14

RTVIGWSTASNSC

26

+ V WST SN C

1

KQVADWSTVSNHC

13

23.1%

NZ_CP068437.1and 2 others:

NZ_CP068437.1 Lanthipeptides: JK628_RS03400_lanthipeptideNZ_CP068437.1 Lanthipeptides: JK628_RS03395_lanthipeptide

Lanthipeptides: allorf_0778008_0778106_lanthipeptide

16

VIGWSTASNSC

26

++ WST SN C

1

LMEWSTISNHC

11

E2L03_RS20345

Leader:

MNQVLDLQKLAHDSNGQGQ

Core:

WSVEKSPATITTTTTAVGWSTASNGC

Core with dehydrations:

WDhaVEKDhaPADhbIDhbDhbDhbDhbDhbAVGWDhaDhbADhaNGCys

antiSMASH-DB 4.0 matches for E2L03_RS20345

100.0%

NZ_CP003923.1and 4 others:

NZ_CP042163.1 Lanthipeptides: FPV17_RS21690_lanthipeptideNZ_CP117834.1 Lanthipeptides: PQ477_RS10645_lanthipeptideNZ_KV917380.1 Lanthipeptides: BK583_RS20900_lanthipeptideNZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20345_lanthipeptide

Lanthipeptides: BLEG1_RS21175_lanthipeptide

1

WSVEKSPATITTTTTAVGWSTASNGC

26

WSVEKSPATITTTTTAVGWSTASNGC

1

WSVEKSPATITTTTTAVGWSTASNGC

26

88.5%

NZ_CP003923.1and 13 others:

NZ_CP003923.1 Lanthipeptides: BLEG1_RS21165_lanthipeptideNZ_CP042163.1 Lanthipeptides: FPV17_RS21700_lanthipeptideNZ_CP042163.1 Lanthipeptides: FPV17_RS21695_lanthipeptideNZ_CP042163.1 Lanthipeptides: FPV17_RS21680_lanthipeptideNZ_CP117834.1 Lanthipeptides: PQ477_RS10655_lanthipeptideNZ_CP117834.1 Lanthipeptides: PQ477_RS10650_lanthipeptideNZ_CP117834.1 Lanthipeptides: PQ477_RS10635_lanthipeptideNZ_KV917380.1 Lanthipeptides: BK583_RS20895_lanthipeptideNZ_KV917380.1 Lanthipeptides: BK583_RS20890_lanthipeptideNZ_KV917380.1 Lanthipeptides: BK583_RS20910_lanthipeptideNZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20355_lanthipeptideNZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20350_lanthipeptideNZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20335_lanthipeptide

Lanthipeptides: BLEG1_RS21185_lanthipeptide

1

WSVEKSPATITTTTTAVGWSTASNGC

26

WSVEKSPAT+T TTTAVGWSTASN C

1

WSVEKSPATVTITTTAVGWSTASNDC

26

84.6%

NZ_CP003923.1and 4 others:

NZ_CP042163.1 Lanthipeptides: FPV17_RS21685_lanthipeptideNZ_CP117834.1 Lanthipeptides: PQ477_RS10640_lanthipeptideNZ_KV917380.1 Lanthipeptides: BK583_RS20905_lanthipeptideNZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20340_lanthipeptide

Lanthipeptides: BLEG1_RS21170_lanthipeptide

1

WSVEKSPATITTTTTAVGWSTASNGC

26

WSVEKSPATITTT T +GWSTASN C

1

WSVEKSPATITTTRTVIGWSTASNSC

26

with 5 more sequence matches

33.3%

NZ_CP066711.1:

Lanthipeptides: allorf_1652598_1652744_lanthipeptide

8

ATITTTTTAVGWSTASNGC

26

AT+ T T G ST SN C

7

ATVEITMTVYGLSTISNKC

25

26.9%

NZ_SMBT01000005.1:

Lanthipeptides: EV682_RS11315_lanthipeptide

15

TAVGWSTASNGC

26

T WST SN C

1

TPADWSTVSNHC

12

24.1%

NZ_CP029710.1:

Lanthipeptides: allorf_5610752_5610895_lanthipeptide

19

WSTASNGC

26

WSTAS GC

21

WSTASTGC

28

20.7%

NZ_FOHE01000012.1:

Lanthipeptides: BMX40_RS20340_lanthipeptide

19

WSTASNGC

26

WST SN C

18

WSTVSNNC

25

16.2%

NZ_CP013666.1and 2 others:

NZ_CP013666.1 Lanthipeptides: AXO1947_RS23410_lanthipeptideNZ_CP036255.1 Lanthipeptides: EYC56_RS24020_lanthipeptide

Lanthipeptides: AXO1947_RS23955_lanthipeptide

19

WSTASNGC

26

WST S+GC

15

WSTGSHGC

22

MIBiG 4.0 matches for E2L03_RS20345

34.6%

BGC0002130.3 (QKI29070.1):

Lanthipeptide: cacaoidin

6

SPATITTTTTAVGWSTASNGC

26

+P TI + +A +TAS GC

3

APCTIYASVSASISATASWGC

23

23.1%

BGC0002111.3 (multiple genes):

Lanthipeptide: andalusicin A or andalusicin B

17

VGWSTASNGC

26

V ST SN C

14

VWASTISNNC

23

E2L03_RS20355

Leader:

MNQVLELQKLATHSNDHGQ

Core:

WSVEKSPATVTITTTAVGWSTASNDC

Core with dehydrations:

WDhaVEKDhaPADhbVDhbIDhbDhbDhbAVGWDhaDhbADhaNDCys

antiSMASH-DB 4.0 matches for E2L03_RS20355

88.5%

NZ_CP003923.1and 4 others:

NZ_CP042163.1 Lanthipeptides: FPV17_RS21690_lanthipeptideNZ_CP117834.1 Lanthipeptides: PQ477_RS10645_lanthipeptideNZ_KV917380.1 Lanthipeptides: BK583_RS20900_lanthipeptideNZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20345_lanthipeptide

Lanthipeptides: BLEG1_RS21175_lanthipeptide

1

WSVEKSPATVTITTTAVGWSTASNDC

26

WSVEKSPAT+T TTTAVGWSTASN C

1

WSVEKSPATITTTTTAVGWSTASNGC

26

86.7%

NZ_CP003923.1and 13 others:

NZ_CP003923.1 Lanthipeptides: BLEG1_RS21185_lanthipeptideNZ_CP042163.1 Lanthipeptides: FPV17_RS21700_lanthipeptideNZ_CP042163.1 Lanthipeptides: FPV17_RS21695_lanthipeptideNZ_CP042163.1 Lanthipeptides: FPV17_RS21680_lanthipeptideNZ_CP117834.1 Lanthipeptides: PQ477_RS10655_lanthipeptideNZ_CP117834.1 Lanthipeptides: PQ477_RS10650_lanthipeptideNZ_CP117834.1 Lanthipeptides: PQ477_RS10635_lanthipeptideNZ_KV917380.1 Lanthipeptides: BK583_RS20910_lanthipeptideNZ_KV917380.1 Lanthipeptides: BK583_RS20895_lanthipeptideNZ_KV917380.1 Lanthipeptides: BK583_RS20890_lanthipeptideNZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20350_lanthipeptideNZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20335_lanthipeptideNZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20355_lanthipeptide

Lanthipeptides: BLEG1_RS21165_lanthipeptide

1

WSVEKSPATVTITTTAVGWSTASNDC

26

WSVEKSPATVTITTTAVGWSTASNDC

5

WSVEKSPATVTITTTAVGWSTASNDC

30

76.9%

NZ_CP003923.1and 4 others:

NZ_CP042163.1 Lanthipeptides: FPV17_RS21685_lanthipeptideNZ_CP117834.1 Lanthipeptides: PQ477_RS10640_lanthipeptideNZ_KV917380.1 Lanthipeptides: BK583_RS20905_lanthipeptideNZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20340_lanthipeptide

Lanthipeptides: BLEG1_RS21170_lanthipeptide

1

WSVEKSPATVTITTTAVGWSTASNDC

26

WSVEKSPAT+T T T +GWSTASN C

1

WSVEKSPATITTTRTVIGWSTASNSC

26

with 4 more sequence matches

40.0%

NZ_CP066711.1:

Lanthipeptides: allorf_1652598_1652744_lanthipeptide

8

ATVTITTTAVGWSTASNDC

26

ATV IT T G ST SN C

7

ATVEITMTVYGLSTISNKC

25

26.9%

NZ_SMBT01000005.1:

Lanthipeptides: EV682_RS11315_lanthipeptide

15

TAVGWSTASNDC

26

T WST SN C

1

TPADWSTVSNHC

12

23.1%

NZ_CP113837.1and 1 other:

NZ_CP113837.1 Lanthipeptides: OU787_RS28895_lanthipeptide

Lanthipeptides: OU787_RS28905_lanthipeptide

19

WSTASNDC

26

WST SN C

1

WSTVSNHC

8

20.7%

NZ_FOHE01000012.1:

Lanthipeptides: BMX40_RS20340_lanthipeptide

19

WSTASNDC

26

WST SN+C

18

WSTVSNNC

25

MIBiG 4.0 matches for E2L03_RS20355

26.9%

BGC0002130.3 (QKI29070.1):

Lanthipeptide: cacaoidin

6

SPATVTITTTAVGWSTASNDC

26

+P T+ + +A +TAS C

3

APCTIYASVSASISATASWGC

23

23.1%

BGC0002111.3 (multiple genes):

Lanthipeptide: andalusicin A or andalusicin B

16

AVGWSTASNDC

26

V ST SN+C

13

GVWASTISNNC

23

13.3%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

18

GWSTASNDC

26

GW T + +C

17

GWCTLTKEC

25

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.46 out of 29.25

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.16 out of 20.97

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.87 out of 20.97

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.80 out of 18.16

Confidence: strong

Additional weak hits (1):

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 23.25 out of 30.98

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

E2L03_RS20335 - Class III

Cleavage pHMM score: -2.30

RODEO score: 0

Monoisotopic mass: 2901.4 Da

Molecular weight: 2903.1 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2921.1 Da N = 1; 2939.1 Da N = 2; 2957.2 Da N = 3; 2975.2 Da N = 4; 2993.2 Da N = 5; 3011.2 Da N = 6; 3029.2 Da N = 7; 3047.3 Da N = 8; 3065.3 Da N = 9

E2L03_RS20340 - Class III

Cleavage pHMM score: -3.30

RODEO score: 0

Monoisotopic mass: 2584.4 Da

Molecular weight: 2585.8 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2603.9 Da N = 1; 2621.9 Da N = 2; 2639.9 Da N = 3; 2657.9 Da N = 4; 2675.9 Da N = 5; 2694.0 Da N = 6; 2712.0 Da N = 7; 2730.0 Da N = 8; 2748.0 Da N = 9; 2766.0 Da N = 10

E2L03_RS20345 - Class III

Cleavage pHMM score: -0.10

RODEO score: 0

Monoisotopic mass: 2457.2 Da

Molecular weight: 2458.7 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2476.7 Da N = 1; 2494.7 Da N = 2; 2512.7 Da N = 3; 2530.7 Da N = 4; 2548.8 Da N = 5; 2566.8 Da N = 6; 2584.8 Da N = 7; 2602.8 Da N = 8; 2620.8 Da N = 9; 2638.9 Da N = 10

E2L03_RS20350 - Class III

Cleavage pHMM score: -1.90

RODEO score: 0

Monoisotopic mass: 2901.4 Da

Molecular weight: 2903.1 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2921.1 Da N = 1; 2939.1 Da N = 2; 2957.2 Da N = 3; 2975.2 Da N = 4; 2993.2 Da N = 5; 3011.2 Da N = 6; 3029.2 Da N = 7; 3047.3 Da N = 8; 3065.3 Da N = 9

E2L03_RS20355 - Class III

Cleavage pHMM score: -0.50

RODEO score: 0

Monoisotopic mass: 2531.3 Da

Molecular weight: 2532.7 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2550.8 Da N = 1; 2568.8 Da N = 2; 2586.8 Da N = 3; 2604.8 Da N = 4; 2622.8 Da N = 5; 2640.9 Da N = 6; 2658.9 Da N = 7; 2676.9 Da N = 8; 2694.9 Da N = 9

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CcpA	Catabolite control protein A
SypG	Regulator of biofilm formation and host colonization

NZ_SNUX01000002.1 - Region 4 - NRPS-like,terpene

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Location: 490,139 - 537,490 nt. (total: 47,352 nt) Show pHMM detection rules used

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

E2L03_RS08760: dihydropteridine reductase

smcogs: SMCOG1159: dihydropteridine reductase

Transferases: PPTase

E2L03_RS08635: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: phosphatase

E2L03_RS08605: inositol monophosphatase

smcogs: SMCOG1207: inositol monophosphatase

Ligases: ligase

E2L03_RS08640: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000647.3	0.48	terpene	carotenoid	Rhodobacter sphaeroides
BGC0000645.3	0.30	terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0002135.2	0.28	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.27	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002164.2	0.27	NRPS	peramine	Epichloe festucae
BGC0002286.3	0.26	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.26	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001641.4	0.26	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.26	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4	0.26	NRPS	AbT1	Aureobasidium pullulans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.61	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.61	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002164.2	0.60	NRPS	peramine	Epichloe festucae
BGC0002286.3	0.60	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.60	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001641.4	0.60	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.60	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4	0.60	NRPS	AbT1	Aureobasidium pullulans
BGC0002276.2	0.60	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001240.4	0.60	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	C30 carotenoid	diapophytoene	C30	acyclic	none

Genes with terpene domains:

E2L03_RS08705: PT_phytoene_like

Domain 1 (4 - 287): Prenyltransferase; Phytoene synthase like

Subtype: Diapophytoene synthase

Reactions:: FPP → diapophytoene

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.77 out of 20.97

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.77 out of 27.78

Confidence: medium

Additional weak hits (2):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.89 out of 30.25

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.71 out of 28.14

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Terpene

TFBS Finder

Predicted core structure(s)

For candidate cluster 7, location 490138 - 537490:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ile)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 8, location 490138 - 533138:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ile)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

E2L03_RS08640: Ile

Search NORINE for peptide: strict or relaxed

AMP-binding (9..403): Ile

nrpys: Ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LETAFDAATFEGFLISGGEFNAYGPTENCVFSTA
Nearest Stachelhaus code(s):: Ile DAGFIGAVFK (62% 8Å match)
Stachelhaus code match:: 90% (moderate)

Link to PARAS substrate predictor

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria

NZ_SNUX01000002.1 - Region 5 - terpene

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Location: 635,050 - 655,970 nt. (total: 20,921 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase dehydratase

E2L03_RS09215: L-carnitine dehydratase/bile acid-inducible

smcogs: SMCOG1189: L-carnitine dehydratase/bile acid-inducible

E2L03_RS09230: Terpene synthase/cyclase metal-binding domain protein

smcogs: SMCOG1052: Terpene synthase/cyclase metal-binding domain protein

Ligases: synthase

E2L03_RS09220: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000897.5	0.31	other (other)	dehydrophos	Streptomyces luridus
BGC0000913.3	0.30	other (other)	MK-8	Enterobacter cloacae
BGC0000992.4	0.28	NRPS, PKS	fusaridione A, (3R,5S)-5-(4-hydroxybenzyl)-3-methyl-3-((2E,4E,6E,8E,10E)-4,8,10-trimethyldodeca-2,4,6,8,10-pentaenoyl)pyrrolidine-2,4-dione	Fusarium heterosporum
BGC0000157.5	0.28	PKS	tautomycetin	Streptomyces sp. CK4412
BGC0000158.5	0.26	PKS	tautomycetin	Streptomyces griseochromogenes
BGC0001706.3	0.26	terpene	nodulisporic acid F	Hypoxylon pulicicidum
BGC0001095.5	0.24	NRPS	fengycin	Bacillus velezensis FZB42
BGC0000159.5	0.23	PKS	tautomycin	Streptomyces spiroverticillatus
BGC0002642.2	0.21	other (other)	clipibycyclene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000994.5	0.20	NRPS, PKS	FR-900520	Streptomyces hygroscopicus subsp. ascomyceticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000897.5	0.31	other (other)	dehydrophos	Streptomyces luridus
BGC0000913.3	0.30	other (other)	MK-8	Enterobacter cloacae
BGC0000992.4	0.28	NRPS, PKS	fusaridione A, (3R,5S)-5-(4-hydroxybenzyl)-3-methyl-3-((2E,4E,6E,8E,10E)-4,8,10-trimethyldodeca-2,4,6,8,10-pentaenoyl)pyrrolidine-2,4-dione	Fusarium heterosporum
BGC0000157.5	0.28	PKS	tautomycetin	Streptomyces sp. CK4412
BGC0000158.5	0.26	PKS	tautomycetin	Streptomyces griseochromogenes
BGC0001706.3	0.26	terpene	nodulisporic acid F	Hypoxylon pulicicidum
BGC0001095.5	0.24	NRPS	fengycin	Bacillus velezensis FZB42
BGC0000159.5	0.23	PKS	tautomycin	Streptomyces spiroverticillatus
BGC0002642.2	0.21	other (other)	clipibycyclene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000994.5	0.20	NRPS, PKS	FR-900520	Streptomyces hygroscopicus subsp. ascomyceticus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

No product predictions

Genes with terpene domains:

E2L03_RS09230: T1TS

Domain 1 (4 - 306): Type 1 terpene synthase

Subtype: unknown

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.31 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.08 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.58 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.24 out of 26.06

Confidence: medium

Additional weak hits (3):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.86 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.56 out of 29.38

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.02 out of 39.62

Confidence: weak

Terpene

TFBS Finder

Glossary

No acronyms to display

TFBS definitions

Regulator	Description
MogR	Repressor of flagellar motility genes

NZ_SNUX01000003.1 - Region 1 - T3PKS

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Location: 15,539 - 56,639 nt. (total: 41,101 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

E2L03_RS10855: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

Transferases: acetyltransferase formyltransferase methyltransferase

E2L03_RS10915: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

E2L03_RS10945: isoprenylcysteine carboxyl methyltransferase

smcogs: SMCOG1150: isoprenylcysteine carboxyl methyltransferase

E2L03_RS11010: methionyl-tRNA formyltransferase

smcogs: SMCOG1228: methionyl-tRNA formyltransferase

Hydrolases: hydrolase

E2L03_RS11000: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Lyases: lyase

E2L03_RS10975: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Ligases: synthase

E2L03_RS10940: chalcone and stilbene synthase domain protein

smcogs: SMCOG1024: chalcone and stilbene synthase domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000282.3	0.54	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3	0.54	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0002645.3	0.41	other (other)	fluopsin C	Pseudomonas aeruginosa PAO1
BGC0000879.5	0.40	other (other)	toyocamycin, sangivamycin	Streptomyces rimosus
BGC0001964.2	0.39	PKS	alkylpyrone-407, alkylpyrone-393	Cystobacterineae bacterium
BGC0002034.3	0.39	other (other)	perquinoline A, perquinoline B, perquinoline C	Streptomyces sp. IB2014 016-6
BGC0000937.5	0.38	other (other)	fosfazinomycin A, fosfazinomycin B	Streptomyces sp. WM6372
BGC0001925.4	0.37	other (other)	altemicidin, SB-203207, SB-203208	Streptomyces sp.
BGC0001663.3	0.37	PKS	merocyclophane C, merocyclophane D	Nostoc sp. UIC 10110
BGC0002282.2	0.37	other (other)	formycin A	Streptomyces kaniharaensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000282.3	0.54	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3	0.54	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0002645.3	0.41	other (other)	fluopsin C	Pseudomonas aeruginosa PAO1
BGC0000879.5	0.40	other (other)	toyocamycin, sangivamycin	Streptomyces rimosus
BGC0001964.2	0.39	PKS	alkylpyrone-407, alkylpyrone-393	Cystobacterineae bacterium
BGC0002034.3	0.39	other (other)	perquinoline A, perquinoline B, perquinoline C	Streptomyces sp. IB2014 016-6
BGC0000937.5	0.38	other (other)	fosfazinomycin A, fosfazinomycin B	Streptomyces sp. WM6372
BGC0001925.4	0.37	other (other)	altemicidin, SB-203207, SB-203208	Streptomyces sp.
BGC0001663.3	0.37	PKS	merocyclophane C, merocyclophane D	Nostoc sp. UIC 10110
BGC0002282.2	0.37	other (other)	formycin A	Streptomyces kaniharaensis

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.35 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.45 out of 26.06

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.52 out of 27.55

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.50 out of 28.19

Confidence: medium

Additional weak hits (2):

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 26.60 out of 39.62

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.99 out of 26.06

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
GnfM	Regulator of nitrogen-fixation genes
MogR	Repressor of flagellar motility genes
ZuR variant 1	Zinc-responsive repressor

NZ_SNUX01000003.1 - Region 2 - NI-siderophore,t3nrps-iterative,terpene

Download region GenBank file

Download region SVG

Location: 607,068 - 686,555 nt. (total: 79,488 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)
t3nrps-iterative: (AMP-binding and PP-binding and (DUF98 or Orn_Arg_deC_N or Orn_DAP_Arg_deC) and not ATP-grasp)
NI-siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

E2L03_RS14055: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

E2L03_RS14075: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

E2L03_RS14080: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

E2L03_RS14095: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

E2L03_RS14180: FAD dependent oxidoreductase

smcogs: SMCOG1103: FAD dependent oxidoreductase

E2L03_RS14190: 3-hydroxybutyryl-CoA dehydrogenase

smcogs: SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase

E2L03_RS14375: 3-hydroxyisobutyrate dehydrogenase

smcogs: SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

E2L03_RS14380: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

E2L03_RS14390: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

E2L03_RS14450: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Transferases: acetyltransferase

E2L03_RS14090: Chloramphenicol acetyltransferase

smcogs: SMCOG1156: Chloramphenicol acetyltransferase

Hydrolases: hydrolase

E2L03_RS14060: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Lyases: decarboxylase

E2L03_RS14345: diaminopimelate decarboxylase

smcogs: SMCOG1264: diaminopimelate decarboxylase

Ligases: ligase

E2L03_RS14235: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000942.4	0.96	other (other)	petrobactin	Bacillus anthracis str. Ames
BGC0002694.2	0.49	other (other)	roseobactin	Phaeobacter inhibens 2.10
BGC0000645.3	0.44	terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0001713.5	0.43	other (other)	ochrobactin	Ochrobactrum anthropi
BGC0002682.2	0.42	other (other)	aerobactin	Vibrio mimicus
BGC0002469.2	0.41	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0001499.5	0.36	other (other)	aerobactin	Pantoea ananatis
BGC0002692.2	0.35	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0001498.5	0.35	other (other)	aerobactin	Xenorhabdus szentirmaii DSM 16338
BGC0002683.2	0.34	NRPS	schizokinen	Nostoc sp. PCC 7120 = FACHB-418

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000942.4	0.77	other (other)	petrobactin	Bacillus anthracis str. Ames
BGC0000645.3	0.74	terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0002694.2	0.59	other (other)	roseobactin	Phaeobacter inhibens 2.10
BGC0000647.3	0.57	terpene	carotenoid	Rhodobacter sphaeroides
BGC0001713.5	0.55	other (other)	ochrobactin	Ochrobactrum anthropi
BGC0000664.5	0.54	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002682.2	0.54	other (other)	aerobactin	Vibrio mimicus
BGC0002469.2	0.53	other (other)	woodybactin A, woodybactin B, woodybactin C, woodybactin D	Shewanella woodyi ATCC 51908
BGC0000751.3	0.52	saccharide	capsular polysaccharide	Actinobacillus pleuropneumoniae
BGC0000641.3	0.51	terpene	carotenoid	Enterobacteriaceae bacterium DC416

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	C30 carotenoid	diapophytoene	C30	acyclic	none

Genes with terpene domains:

E2L03_RS14085: PT_phytoene_like

Domain 1 (4 - 277): Prenyltransferase; Phytoene synthase like

Subtype: Diapophytoene synthase

Reactions:: FPP → diapophytoene

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.45 out of 23.79

Confidence: medium

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 26.16 out of 28.14

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 27.26 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.68 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.36 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.50 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.97 out of 29.38

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.87 out of 27.55

Confidence: medium

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 27.19 out of 33.14

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 25.16 out of 28.19

Confidence: strong

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.16 out of 28.19

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.55 out of 24.78

Confidence: medium

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.20 out of 29.25

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.53 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.87 out of 28.19

Confidence: medium

Additional weak hits (10):

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.82 out of 27.55

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.78 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.18 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.71 out of 32.74

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.56 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.69 out of 32.74

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.74 out of 32.74

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.51 out of 30.25

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 19.14 out of 22.40

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.95 out of 20.01

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

Terpene

TFBS Finder

NRPS/PKS substrate predictions

E2L03_RS14235: X

AMP-binding (13..316): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: EAYIYGLISGVGYAMTSGTMQQYGCSEVGCISIA
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

Link to PARAS substrate predictor

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate

TFBS definitions

Regulator	Description
FuR variant 1	Ferric Uptake Regulator
GnfM	Regulator of nitrogen-fixation genes
IolR	Regulator of the inositol catabolism
LexA variant 2	Repressor of DNA damage response
PerR	Peroxide regulator
SypG	Regulator of biofilm formation and host colonization
ZuR variant 1	Zinc-responsive repressor
ZuR variant 2	Zinc-responsive repressor

NZ_SNUX01000003.1 - Region 3 - glycocin

Download region GenBank file

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Location: 805,069 - 825,287 nt. (total: 20,219 nt) Show pHMM detection rules used

glycocin: (glycocin or sublancin)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000484.5	0.58	ribosomal	glycocin F	Lactobacillus plantarum
BGC0002586.2	0.55	ribosomal	ASM1	Lactiplantibacillus plantarum
BGC0002674.2	0.51	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0001864.3	0.50	ribosomal	listeriocytocin	Listeria monocytogenes SLCC2540
BGC0001862.4	0.48	ribosomal	pallidocin	Aeribacillus pallidus
BGC0000527.5	0.46	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0001210.5	0.44	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000626.3	0.44	ribosomal	thuricin	Bacillus thuringiensis
BGC0001787.3	0.43	ribosomal	suicin 3908	Streptococcus suis
BGC0000539.5	0.43	ribosomal	nukacin ISK-1	Staphylococcus warneri

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000484.5	0.58	ribosomal	glycocin F	Lactobacillus plantarum
BGC0002586.2	0.55	ribosomal	ASM1	Lactiplantibacillus plantarum
BGC0002674.2	0.51	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0001864.3	0.50	ribosomal	listeriocytocin	Listeria monocytogenes SLCC2540
BGC0001862.4	0.48	ribosomal	pallidocin	Aeribacillus pallidus
BGC0000527.5	0.46	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0001210.5	0.44	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000626.3	0.44	ribosomal	thuricin	Bacillus thuringiensis
BGC0001787.3	0.43	ribosomal	suicin 3908	Streptococcus suis
BGC0000539.5	0.43	ribosomal	nukacin ISK-1	Staphylococcus warneri

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 16.87 out of 18.16

Confidence: strong

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 15.96 out of 18.16

Confidence: strong

Additional weak hits (5):

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 23.27 out of 36.53

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.02 out of 39.62

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.16 out of 32.74

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 23.65 out of 30.98

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator

NZ_SNUX01000004.1 - Region 1 - terpene

Download region GenBank file

Download region SVG

Location: 444,520 - 466,403 nt. (total: 21,884 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

E2L03_RS17765: NADH:flavin oxidoreductase/NADH oxidase

smcogs: SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

Ligases: ligase

E2L03_RS17835: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Translocases: transporter

E2L03_RS17785: sugar-binding lipoprotein

smcogs: SMCOG1143: sugar-binding lipoprotein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002405.2	0.46	saccharide	mid-chain acyl sugars	Solanum lycopersicum
BGC0000764.3	0.37	saccharide	exopolysaccharide	Lactococcus lactis
BGC0000597.4	0.37	ribosomal	SWA-2138	Streptomyces sp. e14
BGC0000765.3	0.37	saccharide	exopolysaccharide	Lactobacillus johnsonii
BGC0000595.3	0.37	ribosomal	SCO-2138	Streptomyces coelicolor A3(2)
BGC0000348.4	0.37	NRPS	ergovaline	Epichloe festucae var. lolii
BGC0001267.3	0.36	terpene	elymoclavine, Agroclavine I	Claviceps fusiformis
BGC0002711.2	0.36	PKS	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0000913.3	0.36	other (other)	MK-8	Enterobacter cloacae
BGC0001304.3	0.36	PKS	aflavarin	Aspergillus flavus NRRL3357

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002405.2	0.46	saccharide	mid-chain acyl sugars	Solanum lycopersicum
BGC0000764.3	0.37	saccharide	exopolysaccharide	Lactococcus lactis
BGC0000597.4	0.37	ribosomal	SWA-2138	Streptomyces sp. e14
BGC0000765.3	0.37	saccharide	exopolysaccharide	Lactobacillus johnsonii
BGC0000595.3	0.37	ribosomal	SCO-2138	Streptomyces coelicolor A3(2)
BGC0000348.4	0.37	NRPS	ergovaline	Epichloe festucae var. lolii
BGC0001267.3	0.36	terpene	elymoclavine, Agroclavine I	Claviceps fusiformis
BGC0002711.2	0.36	PKS	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0000913.3	0.36	other (other)	MK-8	Enterobacter cloacae
BGC0001304.3	0.36	PKS	aflavarin	Aspergillus flavus NRRL3357

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	hopanoid		C30	hopanoid skeleton	unknown
triterpene	polypodane		C30	polypodane skeleton	unknown

Genes with terpene domains:

E2L03_RS17800: T2TS

Domain 1 (3 - 626): Type 2 terpene synthase

Subtype: Squalene substrate

Reactions:: squalene → hopanoid; squalene → polypodane

Transcription Factor Binding Sites

Binding sites found:

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.33 out of 25.88

Confidence: medium

Additional weak hits (2):

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.23 out of 33.73

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.05 out of 33.14

Confidence: weak

Terpene

TFBS Finder

Glossary

No acronyms to display

TFBS definitions

Regulator	Description
PsrA	Oleic acid responsive regulator

NZ_SNUX01000004.1 - Region 2 - terpene

Download region GenBank file

Download region SVG

Location: 687,118 - 708,908 nt. (total: 21,791 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002173.2	0.47	saccharide, terpene	fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol	Aspergillus fumigatus A1163
BGC0000487.5	0.40	ribosomal	carnocyclin	Carnobacterium maltaromaticum
BGC0000916.5	0.39	other (other)	molybdenum cofactor	Staphylococcus carnosus
BGC0002531.3	0.38	NRPS	cepaciachelin	Burkholderia ambifaria AMMD
BGC0001684.3	0.37	other (other)	N-acyloxyacyl glutamine	Klebsiella variicola
BGC0000488.4	0.37	ribosomal	circularin A	Clostridium beijerinckii
BGC0002284.3	0.37	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000548.4	0.37	ribosomal	salivaricin A	Streptococcus salivarius
BGC0002339.3	0.36	terpene	2-hydroxysorangiadenosine	Vitiosangium cumulatum
BGC0000043.5	0.36	PKS	curacin A	Moorea producens 19L

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002173.2	0.47	saccharide, terpene	fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol	Aspergillus fumigatus A1163
BGC0000487.5	0.40	ribosomal	carnocyclin	Carnobacterium maltaromaticum
BGC0000916.5	0.39	other (other)	molybdenum cofactor	Staphylococcus carnosus
BGC0002531.3	0.38	NRPS	cepaciachelin	Burkholderia ambifaria AMMD
BGC0001684.3	0.37	other (other)	N-acyloxyacyl glutamine	Klebsiella variicola
BGC0000488.4	0.37	ribosomal	circularin A	Clostridium beijerinckii
BGC0002284.3	0.37	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000548.4	0.37	ribosomal	salivaricin A	Streptococcus salivarius
BGC0002339.3	0.36	terpene	2-hydroxysorangiadenosine	Vitiosangium cumulatum
BGC0000043.5	0.36	PKS	curacin A	Moorea producens 19L

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	hopanoid		C30	hopanoid skeleton	unknown
triterpene	polypodane		C30	polypodane skeleton	unknown

Genes with terpene domains:

E2L03_RS18965: T2TS

Domain 1 (8 - 591): Type 2 terpene synthase

Subtype: Squalene substrate

Reactions:: squalene → hopanoid; squalene → polypodane

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.65 out of 18.46

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 28.43 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.91 out of 29.38

Confidence: medium

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.31 out of 26.85

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.46 out of 28.19

Confidence: strong

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.73 out of 28.19

Confidence: strong

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.98 out of 28.19

Confidence: strong

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.73 out of 28.19

Confidence: medium

Additional weak hits (5):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.73 out of 30.25

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.94 out of 19.52

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.14 out of 32.74

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.34 out of 29.38

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.37 out of 30.98

Confidence: weak

Terpene

TFBS Finder

Glossary

No acronyms to display

TFBS definitions

Regulator	Description
FuR variant 1	Ferric Uptake Regulator
RpoN	Regulator of nitrogen assimilation and virulence
RutR	Regulator of the pyrimidine and purine metabolism
ZuR variant 1	Zinc-responsive repressor