Select genomic region:
Overview
1.1
2.1
2.2
2.3
2.4
2.5
3.1
3.2
3.3
4.1
4.2

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_SNUX01000001.1 (Shouchella lehensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | terpene-precursor | 530,773 | 551,657 |  |

NZ_SNUX01000002.1 (Shouchella lehensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 2.1 | ectoine | 292,784 | 303,179 | Medium | ectoine | other:other
Region 2.2 | NRPS,NRPS-like,T1PKS,terpene-precursor | 339,423 | 395,253 |
Region 2.3 | lanthipeptide-class-iii | 440,215 | 462,833 | High | andalusicin A/andalusicin B | ribosomal:RiPP:Lanthipeptide
Region 2.4 | NRPS-like,terpene | 490,139 | 537,490 |
Region 2.5 | terpene | 635,050 | 655,970 |

NZ_SNUX01000003.1 (Shouchella lehensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 3.1 | T3PKS | 15,539 | 56,639 |  |
Region 3.2 | terpene,t3nrps-iterative,NI-siderophore | 607,068 | 686,555 | Low | carotenoid | terpene
Region 3.3 | glycocin | 805,069 | 825,287 |

NZ_SNUX01000004.1 (Shouchella lehensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 4.1 | terpene | 444,520 | 466,403 |
Region 4.2 | terpene | 687,118 | 708,908 | Low | bacillomycin D | NRPS:Type I+PKS

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | terpene-precursor | 530,773 | 551,657 |  |
Region 2.1 | ectoine | 292,784 | 303,179 | Medium | ectoine | other:other
Region 2.2 | NRPS,NRPS-like,T1PKS,terpene-precursor | 339,423 | 395,253 |
Region 2.3 | lanthipeptide-class-iii | 440,215 | 462,833 | High | andalusicin A/andalusicin B | ribosomal:RiPP:Lanthipeptide
Region 2.4 | NRPS-like,terpene | 490,139 | 537,490 |
Region 2.5 | terpene | 635,050 | 655,970 |
Region 3.1 | T3PKS | 15,539 | 56,639 |  |
Region 3.2 | terpene,t3nrps-iterative,NI-siderophore | 607,068 | 686,555 | Low | carotenoid | terpene
Region 3.3 | glycocin | 805,069 | 825,287 |
Region 4.1 | terpene | 444,520 | 466,403 |
Region 4.2 | terpene | 687,118 | 708,908 | Low | bacillomycin D | NRPS:Type I+PKS

No secondary metabolite regions were found in these records:
  NZ_SNUX01000005.1 (Shouchella lehensis)
  NZ_SNUX01000006.1 (Shouchella lehensis)
  NZ_SNUX01000007.1 (Shouchella lehensis)
  NZ_SNUX01000008.1 (Shouchella lehensis)

Compact view
NZ_SNUX01000001.1 - Region 1 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 530,773 - 551,657 nt. (total: 20,885 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: carboxylase
E2L03_RS02795: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase
E2L03_RS02765: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

E2L03_RS02770: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.38 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0000665.5 |  | 0.38 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0002284.3 |  | 0.38 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000639.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0000668.5 |  | 0.37 | other (other), terpene | 12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole | Hapalosiphon welwitschii UTEX B 1830

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.38 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0000665.5 |  | 0.38 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0002284.3 |  | 0.38 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000639.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0000668.5 |  | 0.37 | other (other), terpene | 12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole | Hapalosiphon welwitschii UTEX B 1830

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
E2L03_RS02770: PT_FPPS_like
Domain 1 (33 - 293): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  DMAPP, IPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.15 out of 26.06
Confidence: medium
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.21 out of 25.88
Confidence: medium
Additional weak hits (2):
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.64 out of 30.25
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.89 out of 30.25
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
MogR | Repressor of flagellar motility genes
PsrA | Oleic acid responsive regulator

NZ_SNUX01000002.1 - Region 1 - ectoine
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 292,784 - 303,179 nt. (total: 10,396 nt) Show pHMM detection rules used
ectoine: ectoine_synt

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: aminotransferase
E2L03_RS07615: aminotransferase class-III

smcogs
  SMCOG1013: aminotransferase class-III

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ectoine | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000858.3 |  | 0.73 | other (other) | ectoine | Methylobacter marinus
BGC0000855.3 |  | 0.72 | other (other) | ectoine | Methylomicrobium kenyense
BGC0000856.3 |  | 0.72 | other (other) | ectoine | Methylophaga thalassica
BGC0000852.5 |  | 0.71 | other (other) | ectoine | Sporosarcina pasteurii
BGC0000859.3 |  | 0.66 | other (other) | ectoine | Methylomicrobium alcaliphilum
BGC0000857.3 |  | 0.64 | other (other) | ectoine | Methylophaga alcalica
BGC0000853.3 |  | 0.58 | other (other) | ectoine | Streptomyces anulatus
BGC0002052.3 |  | 0.58 | other (ectoine) | ectoine | Streptomyces sp.
BGC0000854.3 |  | 0.52 | other (other) | ectoine | Methylomicrobium alcaliphilum 20Z
BGC0000860.3 |  | 0.51 | other (other) | ectoine | Methylarcula marina

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000858.3 |  | 0.73 | other (other) | ectoine | Methylobacter marinus
BGC0000855.3 |  | 0.72 | other (other) | ectoine | Methylomicrobium kenyense
BGC0000856.3 |  | 0.72 | other (other) | ectoine | Methylophaga thalassica
BGC0000852.5 |  | 0.71 | other (other) | ectoine | Sporosarcina pasteurii
BGC0000859.3 |  | 0.66 | other (other) | ectoine | Methylomicrobium alcaliphilum
BGC0000857.3 |  | 0.64 | other (other) | ectoine | Methylophaga alcalica
BGC0000853.3 |  | 0.58 | other (other) | ectoine | Streptomyces anulatus
BGC0002052.3 |  | 0.58 | other (ectoine) | ectoine | Streptomyces sp.
BGC0000854.3 |  | 0.52 | other (other) | ectoine | Methylomicrobium alcaliphilum 20Z
BGC0000860.3 |  | 0.51 | other (other) | ectoine | Methylarcula marina

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.31 out of 26.06
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.11 out of 27.55
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.25 out of 20.97
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.11 out of 26.06
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.52 out of 28.19
Confidence: medium
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
GnfM | Regulator of nitrogen-fixation genes
MogR | Repressor of flagellar motility genes
ZuR variant 1 | Zinc-responsive repressor

NZ_SNUX01000002.1 - Region 2 - NRPS,NRPS-like,T1PKS,terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 339,423 - 395,253 nt. (total: 55,831 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: PPTase acetyltransferase acylase methyltransferase
E2L03_RS07815: methyltransferase

smcogs
  SMCOG1089: methyltransferase

E2L03_RS07880: GCN5-related N-acetyltransferase

smcogs
  SMCOG1111: GCN5-related N-acetyltransferase

E2L03_RS07965: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

E2L03_RS07975: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: hydrolase
E2L03_RS07875: amidohydrolase

smcogs
  SMCOG1244: amidohydrolase

Ligases: ligase
E2L03_RS07930: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

E2L03_RS07940: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Translocases: transport
E2L03_RS07950: MMPL domain-containing transport protein

smcogs
  SMCOG1035: MMPL domain-containing transport protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | NRPS-like | T1PKS | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | --- | ---
BGC0001164.3 |  |  |  |  | 1.01 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0001244.3 |  |  |  |  | 0.95 | PKS | (-)-Mellein | Parastagonospora nodorum
BGC0002192.3 |  |  |  |  | 0.89 | PKS | FR901512 | fungal sp. No.14919
BGC0001250.4 |  |  |  |  | 0.86 | NRPS | epichloenin A | Epichloe festucae
BGC0001268.4 |  |  |  |  | 0.84 | NRPS, PKS | fusarin C | Fusarium fujikuroi
BGC0001284.4 |  |  |  |  | 0.84 | PKS | alternariol | Parastagonospora nodorum SN15
BGC0001254.3 |  |  |  |  | 0.82 | PKS | ACT-Toxin II | Alternaria alternata
BGC0001160.5 |  |  |  |  | 0.79 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0000107.3 |  |  |  |  | 0.78 | PKS | naphthopyrone | Aspergillus nidulans FGSC A4
BGC0001257.3 |  |  |  |  | 0.78 | PKS | 1,3,6,8-tetrahydroxynaphthalene | Nodulisporium sp. ATCC74245

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001244.3 |  | 0.65 | PKS | (-)-Mellein | Parastagonospora nodorum
BGC0002192.3 |  | 0.63 | PKS | FR901512 | fungal sp. No.14919
BGC0001250.4 |  | 0.62 | NRPS | epichloenin A | Epichloe festucae
BGC0001268.4 |  | 0.62 | NRPS, PKS | fusarin C | Fusarium fujikuroi
BGC0001284.4 |  | 0.62 | PKS | alternariol | Parastagonospora nodorum SN15
BGC0001254.3 |  | 0.61 | PKS | ACT-Toxin II | Alternaria alternata
BGC0001164.3 |  | 0.60 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0001160.5 |  | 0.60 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0000107.3 |  | 0.59 | PKS | naphthopyrone | Aspergillus nidulans FGSC A4
BGC0001257.3 |  | 0.59 | PKS | 1,3,6,8-tetrahydroxynaphthalene | Nodulisporium sp. ATCC74245

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP
diterpene precursor |  | GGPP | C20 | acyclic | PP
sesterterpene precursor |  | GFPP | C25 | acyclic | PP
triterpene precursor |  | HPP | C30 | acyclic | PP

Genes with terpene domains:
E2L03_RS07980: PT_FPPS_like
Domain 1 (88 - 279): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: unknown

Reactions:
  IPP, DMAPP → FPP
  IPP, DMAPP → GGPP
  IPP, DMAPP → GFPP
  IPP, DMAPP → HPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.28 out of 20.01
Confidence: medium
RicR
Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 27.28 out of 32.93
Confidence: medium
Additional weak hits (7):
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 22.09 out of 30.11
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 23.18 out of 30.11
Confidence: weak
CsoR
Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 25.30 out of 32.38
Confidence: weak
CsoR
Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 20.20 out of 32.38
Confidence: weak
RicR
Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 22.94 out of 32.93
Confidence: weak
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.61 out of 27.04
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
Terpene
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 339422 - 395253:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (fatty_acid - ohmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 339422 - 385008:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (fatty_acid - ohmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 346166 - 395253:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (fatty_acid - ohmal)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
E2L03_RS07930: Ser
Search NORINE for peptide: strict or relaxed
AMP-binding (664..1069): Ser
nrpys: Ser

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    ser (Ser)
  Single AA prediction:
    ser (Ser)

Stachelhaus prediction details:
  Stachelhaus sequence:
    RWHTFDVSVWEWHFLFSGEANLYGPTEASIDVTC
  Nearest Stachelhaus code(s):
    Ser DVWHLSLIDK (85% 8Å match)
  Stachelhaus code match:
    100% (strong)

E2L03_RS07940: fatty_acid - mal
CAL_domain (181..495): fatty_acid
minowa: fatty_acid

Prediction, score:
  fatty_acid: 73.3
  NH2: 36.1
  Acetyl-CoA: 7.8
  shikimic_acid: 0.0
  AHBA: 0.0

PKS_AT (1254..1543): mal
ATSignature: Malonyl-CoA, inactive

Top 3 matches:
  Malonyl-CoA: 79.2%
  inactive: 79.2%
  Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 119.2
  inactive: 103.5
  Methoxymalonyl-CoA: 60.9
  Methylmalonyl-CoA: 56.0
  Propionyl-CoA: 31.4
  Ethylmalonyl-CoA: 27.2
  2-Methylbutyryl-CoA: 19.6
  Benzoyl-CoA: 14.6
  Acetyl-CoA: 9.7
  Isobutyryl-CoA: 9.3
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  CHC-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0

E2L03_RS07965: mxmal
PKS_AT (7..294): mxmal
ATSignature: (unknown)
No matches above 50%
minowa: Methoxymalonyl-CoA

Prediction, score:
  Methoxymalonyl-CoA: 23.0
  Methylmalonyl-CoA: 12.8
  Malonyl-CoA: 9.7
  Isobutyryl-CoA: 8.7
  trans-1,2-CPDA: 0.0
  inactive: 0.0
  fatty_acid: 0.0
  Propionyl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
GFPP | Geranylfarnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
HPP | Hexaprenyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArgR | Regulator of arginine biosynthesis genes
RicR | Copper-responsive regulator
ToxT | Regulator of MSHA biosynthesis

NZ_SNUX01000002.1 - Region 3 - lanthipeptide-class-iii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 440,215 - 462,833 nt. (total: 22,619 nt) Show pHMM detection rules used
lanthipeptide-class-iii: (micKC and not PKS_KS)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: methyltransferase
E2L03_RS08365: methyltransferase

smcogs
  SMCOG1248: methyltransferase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-iii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002700.2 |  | 0.73 | ribosomal | bacinapeptin | Bacillus nakamurai
BGC0002111.3 |  | 0.59 | ribosomal | andalusicin A, andalusicin B | Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0000551.5 |  | 0.53 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000519.4 |  | 0.51 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000496.5 |  | 0.50 | ribosomal | AmfS | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000513.3 |  | 0.50 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0000518.3 |  | 0.49 | ribosomal | informatipeptin | Streptomyces viridochromogenes DSM 40736
BGC0000553.3 |  | 0.48 | ribosomal | SRO15-2212 | Streptomyces filamentosus NRRL 15998
BGC0002701.2 |  | 0.47 | ribosomal | paenithipeptin | Paenibacillus thiaminolyticus
BGC0001210.5 |  | 0.44 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002700.2 |  | 0.73 | ribosomal | bacinapeptin | Bacillus nakamurai
BGC0002111.3 |  | 0.59 | ribosomal | andalusicin A, andalusicin B | Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0000551.5 |  | 0.53 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000519.4 |  | 0.51 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000496.5 |  | 0.50 | ribosomal | AmfS | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000513.3 |  | 0.50 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0000518.3 |  | 0.49 | ribosomal | informatipeptin | Streptomyces viridochromogenes DSM 40736
BGC0000553.3 |  | 0.48 | ribosomal | SRO15-2212 | Streptomyces filamentosus NRRL 15998
BGC0002701.2 |  | 0.47 | ribosomal | paenithipeptin | Paenibacillus thiaminolyticus
BGC0001210.5 |  | 0.44 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for E2L03_RS08360

E2L03_RS20335
Leader:
MNQVLELQKLAHEVD
E2L03_RS20350
Leader:
MNQVLDLQKLAHEVD
Shared core:
G Q G Q W S V E K S P A T V T I T T T A V G W S T A S N D C
Core with dehydrations:
G Q G Q W Dha V E K Dha P A Dhb V Dhb I Dhb Dhb Dhb A V G W Dha Dhb A Dha N D Cys

#### antiSMASH-DB 4.0 matches for E2L03_RS20335

100.0%
NZ_CP003923.1 and 3 others:
NZ_KV917380.1 Lanthipeptides: BK583_RS20910_lanthipeptide NZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20350_lanthipeptide NZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20335_lanthipeptide
Lanthipeptides: BLEG1_RS21165_lanthipeptide
1
G Q G Q W S V E K S P A T V T I T T T A V G W S T A S N D C
30
G Q G Q W S V E K S P A T V T I T T T A V G W S T A S N D C
1
G Q G Q W S V E K S P A T V T I T T T A V G W S T A S N D C
30
90.0%
NZ_CP042163.1 and 1 other:
NZ_CP117834.1 Lanthipeptides: PQ477_RS10645_lanthipeptide
Lanthipeptides: FPV17_RS21690_lanthipeptide
1
G Q G Q W S V E K S P A T V T I T T T A V G W S T A S N D C
30
G Q G Q W S V E K S P A T+T T T T A V G W S T A S N C
1
G Q G Q W S V E K S P A T I T T T T T A V G W S T A S N G C
30
86.7%
NZ_CP003923.1 and 9 others:
NZ_CP042163.1 Lanthipeptides: FPV17_RS21700_lanthipeptide NZ_CP042163.1 Lanthipeptides: FPV17_RS21695_lanthipeptide NZ_CP042163.1 Lanthipeptides: FPV17_RS21680_lanthipeptide NZ_CP117834.1 Lanthipeptides: PQ477_RS10655_lanthipeptide NZ_CP117834.1 Lanthipeptides: PQ477_RS10650_lanthipeptide NZ_CP117834.1 Lanthipeptides: PQ477_RS10635_lanthipeptide NZ_KV917380.1 Lanthipeptides: BK583_RS20895_lanthipeptide NZ_KV917380.1 Lanthipeptides: BK583_RS20890_lanthipeptide NZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20355_lanthipeptide
Lanthipeptides: BLEG1_RS21185_lanthipeptide
5
W S V E K S P A T V T I T T T A V G W S T A S N D C
30
W S V E K S P A T V T I T T T A V G W S T A S N D C
1
W S V E K S P A T V T I T T T A V G W S T A S N D C
26
with 6 more sequence matches
76.7%
NZ_CP003923.1 and 2 others:
NZ_KV917380.1 Lanthipeptides: BK583_RS20900_lanthipeptide NZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20345_lanthipeptide
Lanthipeptides: BLEG1_RS21175_lanthipeptide
5
W S V E K S P A T V T I T T T A V G W S T A S N D C
30
W S V E K S P A T+T T T T A V G W S T A S N C
1
W S V E K S P A T I T T T T T A V G W S T A S N G C
26
66.7%
NZ_CP003923.1 and 4 others:
NZ_CP042163.1 Lanthipeptides: FPV17_RS21685_lanthipeptide NZ_CP117834.1 Lanthipeptides: PQ477_RS10640_lanthipeptide NZ_KV917380.1 Lanthipeptides: BK583_RS20905_lanthipeptide NZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20340_lanthipeptide
Lanthipeptides: BLEG1_RS21170_lanthipeptide
5
W S V E K S P A T V T I T T T A V G W S T A S N D C
30
W S V E K S P A T+T T T +G W S T A S N C
1
W S V E K S P A T I T T T R T V I G W S T A S N S C
26
40.0%
NZ_CP066711.1:
Lanthipeptides: allorf_1652598_1652744_lanthipeptide
12
A T V T I T T T A V G W S T A S N D C
30
A T V I T T G S T S N C
7
A T V E I T M T V Y G L S T I S N K C
25
23.3%
NZ_SMBT01000005.1:
Lanthipeptides: EV682_RS11315_lanthipeptide
19
T A V G W S T A S N D C
30
T W S T S N C
1
T P A D W S T V S N H C
12
20.0%
NZ_CP113837.1 and 1 other:
NZ_CP113837.1 Lanthipeptides: OU787_RS28895_lanthipeptide
Lanthipeptides: OU787_RS28905_lanthipeptide
23
W S T A S N D C
30
W S T S N C
1
W S T V S N H C
8
20.0%
NZ_FOHE01000012.1:
Lanthipeptides: BMX40_RS20340_lanthipeptide
23
W S T A S N D C
30
W S T S N+C
18
W S T V S N N C
25

#### MIBiG 4.0 matches for E2L03_RS20335

23.3%
BGC0002130.3 (QKI29070.1):
Lanthipeptide: cacaoidin
8
E K S P A T V T I T T T A V G W S T A S N D C
30
+P T+ + +A +T A S C
1
S S A P C T I Y A S V S A S I S A T A S W G C
23
20.0%
BGC0002111.3 (multiple genes):
Lanthipeptide: andalusicin A or andalusicin B
21
V G W S T A S N D C
30
V S T S N+C
14
V W A S T I S N N C
23
13.3%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
22
G W S T A S N D C
30
G W T + +C
17
G W C T L T K E C
25
E2L03_RS20340
Leader:
MNQVLELQKLAHDSDGQEQ
Core:
W S V E K S P A T I T T T R T V I G W S T A S N S C
Core with dehydrations:
W Dha V E K Dha P A Dhb I Dhb Dhb Dhb R Dhb V I G W Dha Dhb A Dha N Dha Cys

#### antiSMASH-DB 4.0 matches for E2L03_RS20340

100.0%
NZ_CP003923.1 and 4 others:
NZ_CP042163.1 Lanthipeptides: FPV17_RS21685_lanthipeptide NZ_CP117834.1 Lanthipeptides: PQ477_RS10640_lanthipeptide NZ_KV917380.1 Lanthipeptides: BK583_RS20905_lanthipeptide NZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20340_lanthipeptide
Lanthipeptides: BLEG1_RS21170_lanthipeptide
1
W S V E K S P A T I T T T R T V I G W S T A S N S C
26
W S V E K S P A T I T T T R T V I G W S T A S N S C
1
W S V E K S P A T I T T T R T V I G W S T A S N S C
26
84.6%
NZ_CP003923.1 and 4 others:
NZ_CP042163.1 Lanthipeptides: FPV17_RS21690_lanthipeptide NZ_CP117834.1 Lanthipeptides: PQ477_RS10645_lanthipeptide NZ_KV917380.1 Lanthipeptides: BK583_RS20900_lanthipeptide NZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20345_lanthipeptide
Lanthipeptides: BLEG1_RS21175_lanthipeptide
1
W S V E K S P A T I T T T R T V I G W S T A S N S C
26
W S V E K S P A T I T T T T +G W S T A S N C
1
W S V E K S P A T I T T T T T A V G W S T A S N G C
26
66.7%
NZ_CP003923.1 and 13 others:
NZ_CP003923.1 Lanthipeptides: BLEG1_RS21185_lanthipeptide NZ_CP042163.1 Lanthipeptides: FPV17_RS21700_lanthipeptide NZ_CP042163.1 Lanthipeptides: FPV17_RS21695_lanthipeptide NZ_CP042163.1 Lanthipeptides: FPV17_RS21680_lanthipeptide NZ_CP117834.1 Lanthipeptides: PQ477_RS10655_lanthipeptide NZ_CP117834.1 Lanthipeptides: PQ477_RS10650_lanthipeptide NZ_CP117834.1 Lanthipeptides: PQ477_RS10635_lanthipeptide NZ_KV917380.1 Lanthipeptides: BK583_RS20910_lanthipeptide NZ_KV917380.1 Lanthipeptides: BK583_RS20895_lanthipeptide NZ_KV917380.1 Lanthipeptides: BK583_RS20890_lanthipeptide NZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20350_lanthipeptide NZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20335_lanthipeptide NZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20355_lanthipeptide
Lanthipeptides: BLEG1_RS21165_lanthipeptide
1
W S V E K S P A T I T T T R T V I G W S T A S N S C
26
W S V E K S P A T+T T T +G W S T A S N C
5
W S V E K S P A T V T I T T T A V G W S T A S N D C
30
with 12 more sequence matches
Only the first 10 are displayed here.
36.7%
NZ_CP066711.1:
Lanthipeptides: allorf_1652598_1652744_lanthipeptide
8
A T I T T T R T V I G W S T A S N S C
26
A T+ T T V G S T S N C
7
A T V E I T M T V Y G L S T I S N K C
25
34.6%
NC_014551.1 and 27 others:
NC_014551.1 Lanthipeptides: BAMF_RS41675_lanthipeptide NC_014551.1 Lanthipeptides: BAMF_RS41665_lanthipeptide NC_017188.1 Lanthipeptides: BAMTA208_RS20945_lanthipeptide NC_017188.1 Lanthipeptides: BAMTA208_RS20950_lanthipeptide NC_017188.1 Lanthipeptides: BAMTA208_RS20940_lanthipeptide NZ_CP026010.1 Lanthipeptides: BS11774_RS22090_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20770_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20775_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20765_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21840_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21835_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04865_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04860_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03885_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03890_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03880_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19010_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19005_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20380_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20385_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18880_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18875_lanthipeptide NZ_JALAUK010000033.1 Lanthipeptides: MOE38_RS18580_lanthipeptide NZ_JALAVZ010000001.1 Lanthipeptides: MOF00_RS00405_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19500_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19860_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19855_lanthipeptide
Lanthipeptides: BAMF_RS41670_lanthipeptide
10
I T T T R T V I G W S T A S N S C
26
+T T V+G S T S N+C
2
L T L I T T V V G T S T I S N N C
18
34.6%
NC_014551.1 and 13 others:
NC_017188.1 Lanthipeptides: BAMTA208_RS20935_lanthipeptide NZ_CP026010.1 Lanthipeptides: BS11774_RS22080_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20760_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21830_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04855_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03875_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19015_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20390_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21915_lanthipeptide NZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19785_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18870_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19495_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19845_lanthipeptide
Lanthipeptides: BAMF_RS41660_lanthipeptide
15
T V I G W S T A S N S C
26
T+I G S T S N S C
9
T L I G T S T I S N S C
20
34.5%
NZ_FOHE01000012.1:
Lanthipeptides: BMX40_RS20340_lanthipeptide
9
T I T T T R T V I--G W S T A S N S C
26
T I T T ++ W S T S N+C
6
T I T T V S A I L T T F W S T V S N N C
25
30.8%
NC_014551.1 and 5 others:
NC_017188.1 Lanthipeptides: BAMTA208_RS20930_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20755_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03870_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20395_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19840_lanthipeptide
Lanthipeptides: BAMF_RS41655_lanthipeptide
10
I T T T R T V I G W S T A S N S C
26
+T T++G S T S N+C
2
L T L I T T I V G S S T I S N N C
18
30.8%
NZ_CP026010.1 and 18 others:
NZ_CP026010.1 Lanthipeptides: BS11774_RS22085_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21825_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21845_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04850_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04870_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19020_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19000_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21910_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21930_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21925_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21920_lanthipeptide NZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19790_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18865_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18885_lanthipeptide NZ_JALAVZ010000001.1 Lanthipeptides: MOF00_RS00410_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19490_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19510_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19505_lanthipeptide
Lanthipeptides: BS11774_RS22075_lanthipeptide
10
I T T T R T V I G W S T A S N S C
26
+T T++G S T S N+C
2
L T L I T T I V G T S T I S N N C
18
30.8%
NZ_LN868937.1 and 1 other:
NZ_LN868937.1 Lanthipeptides: BN2144_RS20095_lanthipeptide
Lanthipeptides: BN2144_RS20100_lanthipeptide
15
T V I G W S T A S N S C
26
T+I G S T S N+C
10
T L I G T S T I S N N C
21
28.6%
NZ_FTML01000041.1:
Lanthipeptides: BW937_RS20035_lanthipeptide
4
E K S P A T I T T T R T V I G
18
E S P A + T V I G
6
E T S P A C L Y T G G V V I G
20
26.9%
NZ_CP014222.1:
Lanthipeptides: VN23_RS10390_lanthipeptide
14
R T V I G W S T A S N S C
26
+ V W S T S N C
1
K Q V A D W S T V S N H C
13
23.1%
NZ_CP068437.1 and 2 others:
NZ_CP068437.1 Lanthipeptides: JK628_RS03400_lanthipeptide NZ_CP068437.1 Lanthipeptides: JK628_RS03395_lanthipeptide
Lanthipeptides: allorf_0778008_0778106_lanthipeptide
16
V I G W S T A S N S C
26
++ W S T S N C
1
L M E W S T I S N H C
11
E2L03_RS20345
Leader:
MNQVLDLQKLAHDSNGQGQ
Core:
W S V E K S P A T I T T T T T A V G W S T A S N G C
Core with dehydrations:
W Dha V E K Dha P A Dhb I Dhb Dhb Dhb Dhb Dhb A V G W Dha Dhb A Dha N G Cys

#### antiSMASH-DB 4.0 matches for E2L03_RS20345

100.0%
NZ_CP003923.1 and 4 others:
NZ_CP042163.1 Lanthipeptides: FPV17_RS21690_lanthipeptide NZ_CP117834.1 Lanthipeptides: PQ477_RS10645_lanthipeptide NZ_KV917380.1 Lanthipeptides: BK583_RS20900_lanthipeptide NZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20345_lanthipeptide
Lanthipeptides: BLEG1_RS21175_lanthipeptide
1
W S V E K S P A T I T T T T T A V G W S T A S N G C
26
W S V E K S P A T I T T T T T A V G W S T A S N G C
1
W S V E K S P A T I T T T T T A V G W S T A S N G C
26
88.5%
NZ_CP003923.1 and 13 others:
NZ_CP003923.1 Lanthipeptides: BLEG1_RS21165_lanthipeptide NZ_CP042163.1 Lanthipeptides: FPV17_RS21700_lanthipeptide NZ_CP042163.1 Lanthipeptides: FPV17_RS21695_lanthipeptide NZ_CP042163.1 Lanthipeptides: FPV17_RS21680_lanthipeptide NZ_CP117834.1 Lanthipeptides: PQ477_RS10655_lanthipeptide NZ_CP117834.1 Lanthipeptides: PQ477_RS10650_lanthipeptide NZ_CP117834.1 Lanthipeptides: PQ477_RS10635_lanthipeptide NZ_KV917380.1 Lanthipeptides: BK583_RS20895_lanthipeptide NZ_KV917380.1 Lanthipeptides: BK583_RS20890_lanthipeptide NZ_KV917380.1 Lanthipeptides: BK583_RS20910_lanthipeptide NZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20355_lanthipeptide NZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20350_lanthipeptide NZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20335_lanthipeptide
Lanthipeptides: BLEG1_RS21185_lanthipeptide
1
W S V E K S P A T I T T T T T A V G W S T A S N G C
26
W S V E K S P A T+T T T T A V G W S T A S N C
1
W S V E K S P A T V T I T T T A V G W S T A S N D C
26
84.6%
NZ_CP003923.1 and 4 others:
NZ_CP042163.1 Lanthipeptides: FPV17_RS21685_lanthipeptide NZ_CP117834.1 Lanthipeptides: PQ477_RS10640_lanthipeptide NZ_KV917380.1 Lanthipeptides: BK583_RS20905_lanthipeptide NZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20340_lanthipeptide
Lanthipeptides: BLEG1_RS21170_lanthipeptide
1
W S V E K S P A T I T T T T T A V G W S T A S N G C
26
W S V E K S P A T I T T T T +G W S T A S N C
1
W S V E K S P A T I T T T R T V I G W S T A S N S C
26
with 5 more sequence matches
33.3%
NZ_CP066711.1:
Lanthipeptides: allorf_1652598_1652744_lanthipeptide
8
A T I T T T T T A V G W S T A S N G C
26
A T+ T T G S T S N C
7
A T V E I T M T V Y G L S T I S N K C
25
26.9%
NZ_SMBT01000005.1:
Lanthipeptides: EV682_RS11315_lanthipeptide
15
T A V G W S T A S N G C
26
T W S T S N C
1
T P A D W S T V S N H C
12
24.1%
NZ_CP029710.1:
Lanthipeptides: allorf_5610752_5610895_lanthipeptide
19
W S T A S N G C
26
W S T A S G C
21
W S T A S T G C
28
20.7%
NZ_FOHE01000012.1:
Lanthipeptides: BMX40_RS20340_lanthipeptide
19
W S T A S N G C
26
W S T S N C
18
W S T V S N N C
25
16.2%
NZ_CP013666.1 and 2 others:
NZ_CP013666.1 Lanthipeptides: AXO1947_RS23410_lanthipeptide NZ_CP036255.1 Lanthipeptides: EYC56_RS24020_lanthipeptide
Lanthipeptides: AXO1947_RS23955_lanthipeptide
19
W S T A S N G C
26
W S T S+G C
15
W S T G S H G C
22

#### MIBiG 4.0 matches for E2L03_RS20345

34.6%
BGC0002130.3 (QKI29070.1):
Lanthipeptide: cacaoidin
6
S P A T I T T T T T A V G W S T A S N G C
26
+P T I + +A +T A S G C
3
A P C T I Y A S V S A S I S A T A S W G C
23
23.1%
BGC0002111.3 (multiple genes):
Lanthipeptide: andalusicin A or andalusicin B
17
V G W S T A S N G C
26
V S T S N C
14
V W A S T I S N N C
23
E2L03_RS20355
Leader:
MNQVLELQKLATHSNDHGQ
Core:
W S V E K S P A T V T I T T T A V G W S T A S N D C
Core with dehydrations:
W Dha V E K Dha P A Dhb V Dhb I Dhb Dhb Dhb A V G W Dha Dhb A Dha N D Cys

#### antiSMASH-DB 4.0 matches for E2L03_RS20355

88.5%
NZ_CP003923.1 and 4 others:
NZ_CP042163.1 Lanthipeptides: FPV17_RS21690_lanthipeptide NZ_CP117834.1 Lanthipeptides: PQ477_RS10645_lanthipeptide NZ_KV917380.1 Lanthipeptides: BK583_RS20900_lanthipeptide NZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20345_lanthipeptide
Lanthipeptides: BLEG1_RS21175_lanthipeptide
1
W S V E K S P A T V T I T T T A V G W S T A S N D C
26
W S V E K S P A T+T T T T A V G W S T A S N C
1
W S V E K S P A T I T T T T T A V G W S T A S N G C
26
86.7%
NZ_CP003923.1 and 13 others:
NZ_CP003923.1 Lanthipeptides: BLEG1_RS21185_lanthipeptide NZ_CP042163.1 Lanthipeptides: FPV17_RS21700_lanthipeptide NZ_CP042163.1 Lanthipeptides: FPV17_RS21695_lanthipeptide NZ_CP042163.1 Lanthipeptides: FPV17_RS21680_lanthipeptide NZ_CP117834.1 Lanthipeptides: PQ477_RS10655_lanthipeptide NZ_CP117834.1 Lanthipeptides: PQ477_RS10650_lanthipeptide NZ_CP117834.1 Lanthipeptides: PQ477_RS10635_lanthipeptide NZ_KV917380.1 Lanthipeptides: BK583_RS20910_lanthipeptide NZ_KV917380.1 Lanthipeptides: BK583_RS20895_lanthipeptide NZ_KV917380.1 Lanthipeptides: BK583_RS20890_lanthipeptide NZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20350_lanthipeptide NZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20335_lanthipeptide NZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20355_lanthipeptide
Lanthipeptides: BLEG1_RS21165_lanthipeptide
1
W S V E K S P A T V T I T T T A V G W S T A S N D C
26
W S V E K S P A T V T I T T T A V G W S T A S N D C
5
W S V E K S P A T V T I T T T A V G W S T A S N D C
30
76.9%
NZ_CP003923.1 and 4 others:
NZ_CP042163.1 Lanthipeptides: FPV17_RS21685_lanthipeptide NZ_CP117834.1 Lanthipeptides: PQ477_RS10640_lanthipeptide NZ_KV917380.1 Lanthipeptides: BK583_RS20905_lanthipeptide NZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20340_lanthipeptide
Lanthipeptides: BLEG1_RS21170_lanthipeptide
1
W S V E K S P A T V T I T T T A V G W S T A S N D C
26
W S V E K S P A T+T T T +G W S T A S N C
1
W S V E K S P A T I T T T R T V I G W S T A S N S C
26
with 4 more sequence matches
40.0%
NZ_CP066711.1:
Lanthipeptides: allorf_1652598_1652744_lanthipeptide
8
A T V T I T T T A V G W S T A S N D C
26
A T V I T T G S T S N C
7
A T V E I T M T V Y G L S T I S N K C
25
26.9%
NZ_SMBT01000005.1:
Lanthipeptides: EV682_RS11315_lanthipeptide
15
T A V G W S T A S N D C
26
T W S T S N C
1
T P A D W S T V S N H C
12
23.1%
NZ_CP113837.1 and 1 other:
NZ_CP113837.1 Lanthipeptides: OU787_RS28895_lanthipeptide
Lanthipeptides: OU787_RS28905_lanthipeptide
19
W S T A S N D C
26
W S T S N C
1
W S T V S N H C
8
20.7%
NZ_FOHE01000012.1:
Lanthipeptides: BMX40_RS20340_lanthipeptide
19
W S T A S N D C
26
W S T S N+C
18
W S T V S N N C
25

#### MIBiG 4.0 matches for E2L03_RS20355

26.9%
BGC0002130.3 (QKI29070.1):
Lanthipeptide: cacaoidin
6
S P A T V T I T T T A V G W S T A S N D C
26
+P T+ + +A +T A S C
3
A P C T I Y A S V S A S I S A T A S W G C
23
23.1%
BGC0002111.3 (multiple genes):
Lanthipeptide: andalusicin A or andalusicin B
16
A V G W S T A S N D C
26
V S T S N+C
13
G V W A S T I S N N C
23
13.3%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
18
G W S T A S N D C
26
G W T + +C
17
G W C T L T K E C
25

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.46 out of 29.25
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.16 out of 20.97
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.87 out of 20.97
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.80 out of 18.16
Confidence: strong
Additional weak hits (1):
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 23.25 out of 30.98
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

E2L03_RS20335 - Class III
  Cleavage pHMM score: -2.30
  RODEO score: 0
  Monoisotopic mass: 2901.4 Da
  Molecular weight: 2903.1 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2921.1 Da N = 1
    2939.1 Da N = 2
    2957.2 Da N = 3
    2975.2 Da N = 4
    2993.2 Da N = 5
    3011.2 Da N = 6
    3029.2 Da N = 7
    3047.3 Da N = 8
    3065.3 Da N = 9
E2L03_RS20340 - Class III
  Cleavage pHMM score: -3.30
  RODEO score: 0
  Monoisotopic mass: 2584.4 Da
  Molecular weight: 2585.8 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2603.9 Da N = 1
    2621.9 Da N = 2
    2639.9 Da N = 3
    2657.9 Da N = 4
    2675.9 Da N = 5
    2694.0 Da N = 6
    2712.0 Da N = 7
    2730.0 Da N = 8
    2748.0 Da N = 9
    2766.0 Da N = 10
E2L03_RS20345 - Class III
  Cleavage pHMM score: -0.10
  RODEO score: 0
  Monoisotopic mass: 2457.2 Da
  Molecular weight: 2458.7 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2476.7 Da N = 1
    2494.7 Da N = 2
    2512.7 Da N = 3
    2530.7 Da N = 4
    2548.8 Da N = 5
    2566.8 Da N = 6
    2584.8 Da N = 7
    2602.8 Da N = 8
    2620.8 Da N = 9
    2638.9 Da N = 10
E2L03_RS20350 - Class III
  Cleavage pHMM score: -1.90
  RODEO score: 0
  Monoisotopic mass: 2901.4 Da
  Molecular weight: 2903.1 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2921.1 Da N = 1
    2939.1 Da N = 2
    2957.2 Da N = 3
    2975.2 Da N = 4
    2993.2 Da N = 5
    3011.2 Da N = 6
    3029.2 Da N = 7
    3047.3 Da N = 8
    3065.3 Da N = 9
E2L03_RS20355 - Class III
  Cleavage pHMM score: -0.50
  RODEO score: 0
  Monoisotopic mass: 2531.3 Da
  Molecular weight: 2532.7 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2550.8 Da N = 1
    2568.8 Da N = 2
    2586.8 Da N = 3
    2604.8 Da N = 4
    2622.8 Da N = 5
    2640.9 Da N = 6
    2658.9 Da N = 7
    2676.9 Da N = 8
    2694.9 Da N = 9

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CcpA | Catabolite control protein A
SypG | Regulator of biofilm formation and host colonization

NZ_SNUX01000002.1 - Region 4 - NRPS-like,terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 490,139 - 537,490 nt. (total: 47,352 nt) Show pHMM detection rules used
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
E2L03_RS08760: dihydropteridine reductase

smcogs
  SMCOG1159: dihydropteridine reductase

Transferases: PPTase
E2L03_RS08635: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: phosphatase
E2L03_RS08605: inositol monophosphatase

smcogs
  SMCOG1207: inositol monophosphatase

Ligases: ligase
E2L03_RS08640: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS-like | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000647.3 |  |  | 0.48 | terpene | carotenoid | Rhodobacter sphaeroides
BGC0000645.3 |  |  | 0.30 | terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0002135.2 |  |  | 0.28 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001135.5 |  |  | 0.27 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0002164.2 |  |  | 0.27 | NRPS | peramine | Epichloe festucae
BGC0002286.3 |  |  | 0.26 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4 |  |  | 0.26 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001641.4 |  |  | 0.26 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  |  | 0.26 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4 |  |  | 0.26 | NRPS | AbT1 | Aureobasidium pullulans

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.61 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001135.5 |  | 0.61 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0002164.2 |  | 0.60 | NRPS | peramine | Epichloe festucae
BGC0002286.3 |  | 0.60 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4 |  | 0.60 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001641.4 |  | 0.60 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  | 0.60 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0000307.4 |  | 0.60 | NRPS | AbT1 | Aureobasidium pullulans
BGC0002276.2 |  | 0.60 | NRPS | choline | Aspergillus nidulans FGSC A4
BGC0001240.4 |  | 0.60 | NRPS | serinocyclin A, serinocyclin B | Metarhizium robertsii

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene | C30 carotenoid | diapophytoene | C30 | acyclic | none

Genes with terpene domains:
E2L03_RS08705: PT_phytoene_like
Domain 1 (4 - 287): Prenyltransferase; Phytoene synthase like
Subtype: Diapophytoene synthase

Reactions:
  FPP → diapophytoene

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.77 out of 20.97
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.77 out of 27.78
Confidence: medium
Additional weak hits (2):
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.89 out of 30.25
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.71 out of 28.14
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
Terpene
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 7, location 490138 - 537490:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Ile)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 8, location 490138 - 533138:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Ile)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
E2L03_RS08640: Ile
Search NORINE for peptide: strict or relaxed
AMP-binding (9..403): Ile
nrpys: Ile

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LETAFDAATFEGFLISGGEFNAYGPTENCVFSTA
  Nearest Stachelhaus code(s):
    Ile DAGFIGAVFK (62% 8Å match)
  Stachelhaus code match:
    90% (moderate)

Link to PARAS substrate predictor
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
FPP | Farnesyl diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria

NZ_SNUX01000002.1 - Region 5 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 635,050 - 655,970 nt. (total: 20,921 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: cyclase dehydratase
E2L03_RS09215: L-carnitine dehydratase/bile acid-inducible

smcogs
  SMCOG1189: L-carnitine dehydratase/bile acid-inducible

E2L03_RS09230: Terpene synthase/cyclase metal-binding domain protein

smcogs
  SMCOG1052: Terpene synthase/cyclase metal-binding domain protein

Ligases: synthase
E2L03_RS09220: 2-isopropylmalate synthase

smcogs
  SMCOG1271: 2-isopropylmalate synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000897.5 |  | 0.31 | other (other) | dehydrophos | Streptomyces luridus
BGC0000913.3 |  | 0.30 | other (other) | MK-8 | Enterobacter cloacae
BGC0000992.4 |  | 0.28 | NRPS, PKS | fusaridione A, (3R,5S)-5-(4-hydroxybenzyl)-3-methyl-3-((2E,4E,6E,8E,10E)-4,8,10-trimethyldodeca-2,4,6,8,10-pentaenoyl)pyrrolidine-2,4-dione | Fusarium heterosporum
BGC0000157.5 |  | 0.28 | PKS | tautomycetin | Streptomyces sp. CK4412
BGC0000158.5 |  | 0.26 | PKS | tautomycetin | Streptomyces griseochromogenes
BGC0001706.3 |  | 0.26 | terpene | nodulisporic acid F | Hypoxylon pulicicidum
BGC0001095.5 |  | 0.24 | NRPS | fengycin | Bacillus velezensis FZB42
BGC0000159.5 |  | 0.23 | PKS | tautomycin | Streptomyces spiroverticillatus
BGC0002642.2 |  | 0.21 | other (other) | clipibycyclene | Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000994.5 |  | 0.20 | NRPS, PKS | FR-900520 | Streptomyces hygroscopicus subsp. ascomyceticus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000897.5 |  | 0.31 | other (other) | dehydrophos | Streptomyces luridus
BGC0000913.3 |  | 0.30 | other (other) | MK-8 | Enterobacter cloacae
BGC0000992.4 |  | 0.28 | NRPS, PKS | fusaridione A, (3R,5S)-5-(4-hydroxybenzyl)-3-methyl-3-((2E,4E,6E,8E,10E)-4,8,10-trimethyldodeca-2,4,6,8,10-pentaenoyl)pyrrolidine-2,4-dione | Fusarium heterosporum
BGC0000157.5 |  | 0.28 | PKS | tautomycetin | Streptomyces sp. CK4412
BGC0000158.5 |  | 0.26 | PKS | tautomycetin | Streptomyces griseochromogenes
BGC0001706.3 |  | 0.26 | terpene | nodulisporic acid F | Hypoxylon pulicicidum
BGC0001095.5 |  | 0.24 | NRPS | fengycin | Bacillus velezensis FZB42
BGC0000159.5 |  | 0.23 | PKS | tautomycin | Streptomyces spiroverticillatus
BGC0002642.2 |  | 0.21 | other (other) | clipibycyclene | Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000994.5 |  | 0.20 | NRPS, PKS | FR-900520 | Streptomyces hygroscopicus subsp. ascomyceticus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:
No product predictions
Genes with terpene domains:
E2L03_RS09230: T1TS
Domain 1 (4 - 306): Type 1 terpene synthase
Subtype: unknown
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.31 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.08 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.58 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.24 out of 26.06
Confidence: medium
Additional weak hits (3):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.86 out of 26.06
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.56 out of 29.38
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.02 out of 39.62
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.
No acronyms to display
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
MogR | Repressor of flagellar motility genes

NZ_SNUX01000003.1 - Region 1 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 15,539 - 56,639 nt. (total: 41,101 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
E2L03_RS10855: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

Transferases: acetyltransferase formyltransferase methyltransferase
E2L03_RS10915: GCN5-related N-acetyltransferase

smcogs
  SMCOG1111: GCN5-related N-acetyltransferase

E2L03_RS10945: isoprenylcysteine carboxyl methyltransferase

smcogs
  SMCOG1150: isoprenylcysteine carboxyl methyltransferase

E2L03_RS11010: methionyl-tRNA formyltransferase

smcogs
  SMCOG1228: methionyl-tRNA formyltransferase

Hydrolases: hydrolase
E2L03_RS11000: asparagine synthase (glutamine-hydrolyzing)

smcogs
  SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Lyases: lyase
E2L03_RS10975: argininosuccinate lyase/adenylosuccinate lyase

smcogs
  SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Ligases: synthase
E2L03_RS10940: chalcone and stilbene synthase domain protein

smcogs
  SMCOG1024: chalcone and stilbene synthase domain protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000282.3 |  | 0.54 | PKS | 2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3 |  | 0.54 | PKS | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0002645.3 |  | 0.41 | other (other) | fluopsin C | Pseudomonas aeruginosa PAO1
BGC0000879.5 |  | 0.40 | other (other) | toyocamycin, sangivamycin | Streptomyces rimosus
BGC0001964.2 |  | 0.39 | PKS | alkylpyrone-407, alkylpyrone-393 | Cystobacterineae bacterium
BGC0002034.3 |  | 0.39 | other (other) | perquinoline A, perquinoline B, perquinoline C | Streptomyces sp. IB2014 016-6
BGC0000937.5 |  | 0.38 | other (other) | fosfazinomycin A, fosfazinomycin B | Streptomyces sp. WM6372
BGC0001925.4 |  | 0.37 | other (other) | altemicidin, SB-203207, SB-203208 | Streptomyces sp.
BGC0001663.3 |  | 0.37 | PKS | merocyclophane C, merocyclophane D | Nostoc sp. UIC 10110
BGC0002282.2 |  | 0.37 | other (other) | formycin A | Streptomyces kaniharaensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000282.3 |  | 0.54 | PKS | 2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3 |  | 0.54 | PKS | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0002645.3 |  | 0.41 | other (other) | fluopsin C | Pseudomonas aeruginosa PAO1
BGC0000879.5 |  | 0.40 | other (other) | toyocamycin, sangivamycin | Streptomyces rimosus
BGC0001964.2 |  | 0.39 | PKS | alkylpyrone-407, alkylpyrone-393 | Cystobacterineae bacterium
BGC0002034.3 |  | 0.39 | other (other) | perquinoline A, perquinoline B, perquinoline C | Streptomyces sp. IB2014 016-6
BGC0000937.5 |  | 0.38 | other (other) | fosfazinomycin A, fosfazinomycin B | Streptomyces sp. WM6372
BGC0001925.4 |  | 0.37 | other (other) | altemicidin, SB-203207, SB-203208 | Streptomyces sp.
BGC0001663.3 |  | 0.37 | PKS | merocyclophane C, merocyclophane D | Nostoc sp. UIC 10110
BGC0002282.2 |  | 0.37 | other (other) | formycin A | Streptomyces kaniharaensis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.35 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.45 out of 26.06
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.52 out of 27.55
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.50 out of 28.19
Confidence: medium
Additional weak hits (2):
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 26.60 out of 39.62
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.99 out of 26.06
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
GnfM | Regulator of nitrogen-fixation genes
MogR | Repressor of flagellar motility genes
ZuR variant 1 | Zinc-responsive repressor

NZ_SNUX01000003.1 - Region 2 - NI-siderophore,t3nrps-iterative,terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 607,068 - 686,555 nt. (total: 79,488 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)
t3nrps-iterative: (AMP-binding and PP-binding and (DUF98 or Orn_Arg_deC_N or Orn_DAP_Arg_deC) and not ATP-grasp)
NI-siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase
E2L03_RS14055: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

E2L03_RS14075: dehydrogenase

smcogs
  SMCOG1222: dehydrogenase

E2L03_RS14080: dehydrogenase

smcogs
  SMCOG1222: dehydrogenase

E2L03_RS14095: dehydrogenase

smcogs
  SMCOG1222: dehydrogenase

E2L03_RS14180: FAD dependent oxidoreductase

smcogs
  SMCOG1103: FAD dependent oxidoreductase

E2L03_RS14190: 3-hydroxybutyryl-CoA dehydrogenase

smcogs
  SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase

E2L03_RS14375: 3-hydroxyisobutyrate dehydrogenase

smcogs
  SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

E2L03_RS14380: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

E2L03_RS14390: aldo/keto reductase family oxidoreductase

smcogs
  SMCOG1039: aldo/keto reductase family oxidoreductase

E2L03_RS14450: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

Transferases: acetyltransferase
E2L03_RS14090: Chloramphenicol acetyltransferase

smcogs
  SMCOG1156: Chloramphenicol acetyltransferase

Hydrolases: hydrolase
E2L03_RS14060: asparagine synthase (glutamine-hydrolyzing)

smcogs
  SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Lyases: decarboxylase
E2L03_RS14345: diaminopimelate decarboxylase

smcogs
  SMCOG1264: diaminopimelate decarboxylase

Ligases: ligase
E2L03_RS14235: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | t3nrps-iterative | NI-siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | ---
BGC0000942.4 |  |  |  | 0.96 | other (other) | petrobactin | Bacillus anthracis str. Ames
BGC0002694.2 |  |  |  | 0.49 | other (other) | roseobactin | Phaeobacter inhibens 2.10
BGC0000645.3 |  |  |  | 0.44 | terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0001713.5 |  |  |  | 0.43 | other (other) | ochrobactin | Ochrobactrum anthropi
BGC0002682.2 |  |  |  | 0.42 | other (other) | aerobactin | Vibrio mimicus
BGC0002469.2 |  |  |  | 0.41 | other (other) | woodybactin A, woodybactin B, woodybactin C, woodybactin D | Shewanella woodyi ATCC 51908
BGC0001499.5 |  |  |  | 0.36 | other (other) | aerobactin | Pantoea ananatis
BGC0002692.2 |  |  |  | 0.35 | other (other) | speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B | Kribbella speibonae
BGC0001498.5 |  |  |  | 0.35 | other (other) | aerobactin | Xenorhabdus szentirmaii DSM 16338
BGC0002683.2 |  |  |  | 0.34 | NRPS | schizokinen | Nostoc sp. PCC 7120 = FACHB-418

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000942.4 |  | 0.77 | other (other) | petrobactin | Bacillus anthracis str. Ames
BGC0000645.3 |  | 0.74 | terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0002694.2 |  | 0.59 | other (other) | roseobactin | Phaeobacter inhibens 2.10
BGC0000647.3 |  | 0.57 | terpene | carotenoid | Rhodobacter sphaeroides
BGC0001713.5 |  | 0.55 | other (other) | ochrobactin | Ochrobactrum anthropi
BGC0000664.5 |  | 0.54 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0002682.2 |  | 0.54 | other (other) | aerobactin | Vibrio mimicus
BGC0002469.2 |  | 0.53 | other (other) | woodybactin A, woodybactin B, woodybactin C, woodybactin D | Shewanella woodyi ATCC 51908
BGC0000751.3 |  | 0.52 | saccharide | capsular polysaccharide | Actinobacillus pleuropneumoniae
BGC0000641.3 |  | 0.51 | terpene | carotenoid | Enterobacteriaceae bacterium DC416

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene | C30 carotenoid | diapophytoene | C30 | acyclic | none

Genes with terpene domains:
E2L03_RS14085: PT_phytoene_like
Domain 1 (4 - 277): Prenyltransferase; Phytoene synthase like
Subtype: Diapophytoene synthase

Reactions:
  FPP → diapophytoene

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.45 out of 23.79
Confidence: medium
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 26.16 out of 28.14
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 27.26 out of 29.38
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.68 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.36 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.50 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.97 out of 29.38
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.87 out of 27.55
Confidence: medium
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 27.19 out of 33.14
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 25.16 out of 28.19
Confidence: strong
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.16 out of 28.19
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.55 out of 24.78
Confidence: medium
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.20 out of 29.25
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.53 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.87 out of 28.19
Confidence: medium
Additional weak hits (10):
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.82 out of 27.55
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.78 out of 28.14
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.18 out of 29.38
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.71 out of 32.74
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.56 out of 29.38
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.69 out of 32.74
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.74 out of 32.74
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.51 out of 30.25
Confidence: weak
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 19.14 out of 22.40
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.95 out of 20.01
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS substrates
Terpene
TFBS Finder
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
E2L03_RS14235: X
AMP-binding (13..316): X
nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    EAYIYGLISGVGYAMTSGTMQQYGCSEVGCISIA
  Nearest Stachelhaus code(s):
  Stachelhaus code match:
    0% (weak)

Link to PARAS substrate predictor
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
FPP | Farnesyl diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
FuR variant 1 | Ferric Uptake Regulator
GnfM | Regulator of nitrogen-fixation genes
IolR | Regulator of the inositol catabolism
LexA variant 2 | Repressor of DNA damage response
PerR | Peroxide regulator
SypG | Regulator of biofilm formation and host colonization
ZuR variant 1 | Zinc-responsive repressor
ZuR variant 2 | Zinc-responsive repressor

NZ_SNUX01000003.1 - Region 3 - glycocin
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 805,069 - 825,287 nt. (total: 20,219 nt) Show pHMM detection rules used
glycocin: (glycocin or sublancin)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | glycocin | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000484.5 |  | 0.58 | ribosomal | glycocin F | Lactobacillus plantarum
BGC0002586.2 |  | 0.55 | ribosomal | ASM1 | Lactiplantibacillus plantarum
BGC0002674.2 |  | 0.51 | ribosomal | enterocin F4-9 | Enterococcus faecalis
BGC0001864.3 |  | 0.50 | ribosomal | listeriocytocin | Listeria monocytogenes SLCC2540
BGC0001862.4 |  | 0.48 | ribosomal | pallidocin | Aeribacillus pallidus
BGC0000527.5 |  | 0.46 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0001210.5 |  | 0.44 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000626.3 |  | 0.44 | ribosomal | thuricin | Bacillus thuringiensis
BGC0001787.3 |  | 0.43 | ribosomal | suicin 3908 | Streptococcus suis
BGC0000539.5 |  | 0.43 | ribosomal | nukacin ISK-1 | Staphylococcus warneri

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000484.5 |  | 0.58 | ribosomal | glycocin F | Lactobacillus plantarum
BGC0002586.2 |  | 0.55 | ribosomal | ASM1 | Lactiplantibacillus plantarum
BGC0002674.2 |  | 0.51 | ribosomal | enterocin F4-9 | Enterococcus faecalis
BGC0001864.3 |  | 0.50 | ribosomal | listeriocytocin | Listeria monocytogenes SLCC2540
BGC0001862.4 |  | 0.48 | ribosomal | pallidocin | Aeribacillus pallidus
BGC0000527.5 |  | 0.46 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0001210.5 |  | 0.44 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000626.3 |  | 0.44 | ribosomal | thuricin | Bacillus thuringiensis
BGC0001787.3 |  | 0.43 | ribosomal | suicin 3908 | Streptococcus suis
BGC0000539.5 |  | 0.43 | ribosomal | nukacin ISK-1 | Staphylococcus warneri

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 16.87 out of 18.16
Confidence: strong
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 15.96 out of 18.16
Confidence: strong
Additional weak hits (5):
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 23.27 out of 36.53
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.02 out of 39.62
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.16 out of 32.74
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 23.65 out of 30.98
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator

NZ_SNUX01000004.1 - Region 1 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 444,520 - 466,403 nt. (total: 21,884 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
E2L03_RS17765: NADH:flavin oxidoreductase/NADH oxidase

smcogs
  SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

Ligases: ligase
E2L03_RS17835: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Translocases: transporter
E2L03_RS17785: sugar-binding lipoprotein

smcogs
  SMCOG1143: sugar-binding lipoprotein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002405.2 |  | 0.46 | saccharide | mid-chain acyl sugars | Solanum lycopersicum
BGC0000764.3 |  | 0.37 | saccharide | exopolysaccharide | Lactococcus lactis
BGC0000597.4 |  | 0.37 | ribosomal | SWA-2138 | Streptomyces sp. e14
BGC0000765.3 |  | 0.37 | saccharide | exopolysaccharide | Lactobacillus johnsonii
BGC0000595.3 |  | 0.37 | ribosomal | SCO-2138 | Streptomyces coelicolor A3(2)
BGC0000348.4 |  | 0.37 | NRPS | ergovaline | Epichloe festucae var. lolii
BGC0001267.3 |  | 0.36 | terpene | elymoclavine, Agroclavine I | Claviceps fusiformis
BGC0002711.2 |  | 0.36 | PKS | nostovalerolactone, 9-dehydronostovalerolactone | Nostoc punctiforme PCC 73102
BGC0000913.3 |  | 0.36 | other (other) | MK-8 | Enterobacter cloacae
BGC0001304.3 |  | 0.36 | PKS | aflavarin | Aspergillus flavus NRRL3357

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002405.2 |  | 0.46 | saccharide | mid-chain acyl sugars | Solanum lycopersicum
BGC0000764.3 |  | 0.37 | saccharide | exopolysaccharide | Lactococcus lactis
BGC0000597.4 |  | 0.37 | ribosomal | SWA-2138 | Streptomyces sp. e14
BGC0000765.3 |  | 0.37 | saccharide | exopolysaccharide | Lactobacillus johnsonii
BGC0000595.3 |  | 0.37 | ribosomal | SCO-2138 | Streptomyces coelicolor A3(2)
BGC0000348.4 |  | 0.37 | NRPS | ergovaline | Epichloe festucae var. lolii
BGC0001267.3 |  | 0.36 | terpene | elymoclavine, Agroclavine I | Claviceps fusiformis
BGC0002711.2 |  | 0.36 | PKS | nostovalerolactone, 9-dehydronostovalerolactone | Nostoc punctiforme PCC 73102
BGC0000913.3 |  | 0.36 | other (other) | MK-8 | Enterobacter cloacae
BGC0001304.3 |  | 0.36 | PKS | aflavarin | Aspergillus flavus NRRL3357

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene | hopanoid |  | C30 | hopanoid skeleton | unknown
triterpene | polypodane |  | C30 | polypodane skeleton | unknown

Genes with terpene domains:
E2L03_RS17800: T2TS
Domain 1 (3 - 626): Type 2 terpene synthase
Subtype: Squalene substrate

Reactions:
  squalene → hopanoid
  squalene → polypodane

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.33 out of 25.88
Confidence: medium
Additional weak hits (2):
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.23 out of 33.73
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.05 out of 33.14
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.
No acronyms to display
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
PsrA | Oleic acid responsive regulator

NZ_SNUX01000004.1 - Region 2 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 687,118 - 708,908 nt. (total: 21,791 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002173.2 |  | 0.47 | saccharide, terpene | fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol | Aspergillus fumigatus A1163
BGC0000487.5 |  | 0.40 | ribosomal | carnocyclin | Carnobacterium maltaromaticum
BGC0000916.5 |  | 0.39 | other (other) | molybdenum cofactor | Staphylococcus carnosus
BGC0002531.3 |  | 0.38 | NRPS | cepaciachelin | Burkholderia ambifaria AMMD
BGC0001684.3 |  | 0.37 | other (other) | N-acyloxyacyl glutamine | Klebsiella variicola
BGC0000488.4 |  | 0.37 | ribosomal | circularin A | Clostridium beijerinckii
BGC0002284.3 |  | 0.37 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000548.4 |  | 0.37 | ribosomal | salivaricin A | Streptococcus salivarius
BGC0002339.3 |  | 0.36 | terpene | 2-hydroxysorangiadenosine | Vitiosangium cumulatum
BGC0000043.5 |  | 0.36 | PKS | curacin A | Moorea producens 19L

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002173.2 |  | 0.47 | saccharide, terpene | fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol | Aspergillus fumigatus A1163
BGC0000487.5 |  | 0.40 | ribosomal | carnocyclin | Carnobacterium maltaromaticum
BGC0000916.5 |  | 0.39 | other (other) | molybdenum cofactor | Staphylococcus carnosus
BGC0002531.3 |  | 0.38 | NRPS | cepaciachelin | Burkholderia ambifaria AMMD
BGC0001684.3 |  | 0.37 | other (other) | N-acyloxyacyl glutamine | Klebsiella variicola
BGC0000488.4 |  | 0.37 | ribosomal | circularin A | Clostridium beijerinckii
BGC0002284.3 |  | 0.37 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000548.4 |  | 0.37 | ribosomal | salivaricin A | Streptococcus salivarius
BGC0002339.3 |  | 0.36 | terpene | 2-hydroxysorangiadenosine | Vitiosangium cumulatum
BGC0000043.5 |  | 0.36 | PKS | curacin A | Moorea producens 19L

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene | hopanoid |  | C30 | hopanoid skeleton | unknown
triterpene | polypodane |  | C30 | polypodane skeleton | unknown

Genes with terpene domains:
E2L03_RS18965: T2TS
Domain 1 (8 - 591): Type 2 terpene synthase
Subtype: Squalene substrate

Reactions:
  squalene → hopanoid
  squalene → polypodane

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.65 out of 18.46
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 28.43 out of 29.38
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.91 out of 29.38
Confidence: medium
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.31 out of 26.85
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.46 out of 28.19
Confidence: strong
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.73 out of 28.19
Confidence: strong
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.98 out of 28.19
Confidence: strong
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.73 out of 28.19
Confidence: medium
Additional weak hits (5):
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.73 out of 30.25
Confidence: weak
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.94 out of 19.52
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.14 out of 32.74
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.34 out of 29.38
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.37 out of 30.98
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.
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TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
FuR variant 1 | Ferric Uptake Regulator
RpoN | Regulator of nitrogen assimilation and virulence
RutR | Regulator of the pyrimidine and purine metabolism
ZuR variant 1 | Zinc-responsive repressor