GCF_003868675.1 - 13 region(s)

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Location: 306,034 - 371,444 nt. (total: 65,411 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase reductase

D2M30_RS01700: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

D2M30_RS01715: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

D2M30_RS01730: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

D2M30_RS01745: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

D2M30_RS01900: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

Transferases: PPTase aminotransferase

D2M30_RS01815: aminotransferase

smcogs: SMCOG1019: aminotransferase

D2M30_RS01820: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: esterase

D2M30_RS01810: thioesterase

smcogs: SMCOG1004: thioesterase

Ligases: ligase synthase

D2M30_RS01740: cobalamin synthesis protein/P47K family protein

smcogs: SMCOG1178: cobalamin synthesis protein/P47K family protein

D2M30_RS01795: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

D2M30_RS01805: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

D2M30_RS20800: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

D2M30_RS20810: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000433.5	0.80	NRPS	surfactin	Bacillus velezensis FZB42
BGC0001833.4	0.75	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	0.74	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002075.3	0.73	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0002286.3	0.73	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.73	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.73	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001135.5	0.73	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001758.4	0.72	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001825.4	0.72	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000433.5	0.80	NRPS	surfactin	Bacillus velezensis FZB42
BGC0001833.4	0.75	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	0.74	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002075.3	0.73	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0002286.3	0.73	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4	0.73	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.73	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001135.5	0.73	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001758.4	0.72	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001825.4	0.72	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.55 out of 29.38

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.80 out of 27.78

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.02 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.50 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.76 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.41 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.42 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.88 out of 26.06

Confidence: medium

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 26.49 out of 35.63

Confidence: medium

Additional weak hits (20):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.89 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.74 out of 32.74

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.52 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.40 out of 26.06

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 21.71 out of 33.73

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.87 out of 26.06

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.13 out of 30.97

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.49 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.26 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.21 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 20.78 out of 29.38

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.38 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.99 out of 26.06

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 22.36 out of 32.93

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 21.56 out of 31.73

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.35 out of 30.25

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.59 out of 31.73

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 21.63 out of 30.12

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 22.50 out of 35.63

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.97 out of 30.98

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 306033 - 371444:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Glu - Leu - D-Leu) + (Val) + (Asp - D-Leu) + (Ile)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

D2M30_RS01795: Glu - Leu - Leu

Search NORINE for peptide: strict or relaxed

AMP-binding (465..867): Glu

nrpys: Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: gln (Gln)

Stachelhaus prediction details:

Stachelhaus sequence:: LSLAFDASVKQADGLIGGETNVYGPTETCVDASV
Nearest Stachelhaus code(s):: Glu DAKDLGVVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1511..1908): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: TNTSFDAFMFDGMIMFGGELHMYGPSESTVFATY
Nearest Stachelhaus code(s):: Leu DAFMMGMVFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2550..2939): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: LWHAFDASIWEPFLLVGGDVNNYGPTENTVVATS
Nearest Stachelhaus code(s):: Leu DAWFLGNVVK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

D2M30_RS20800: Val

Search NORINE for peptide: strict or relaxed

AMP-binding (470..864): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: LHSGFDAGTFEGWLIIGGDWNGYGPTENTTFSTS
Nearest Stachelhaus code(s):: Val DAFWIGGTFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

D2M30_RS20810: Asp - Leu

Search NORINE for peptide: strict or relaxed

AMP-binding (429..831): Asp

nrpys: Asp

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asp (Asp)

Stachelhaus prediction details:

Stachelhaus sequence:: YWFSFDLGYTAPKLVLGGEINHYGPTETTIGAIA
Nearest Stachelhaus code(s):: Asp DLTKVGHIGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1474..1863): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: LWHAFDAAIWEPFLLVGGDVNNYGPTENTVVATS
Nearest Stachelhaus code(s):: Leu DAWFLGNVVK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

D2M30_RS01805: Ile

Search NORINE for peptide: strict or relaxed

AMP-binding (469..867): Ile

nrpys: Ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: ile (Ile)

Stachelhaus prediction details:

Stachelhaus sequence:: IHTSFDGFTFDAFVLFGGEIHVYGPTEVTVFATA
Nearest Stachelhaus code(s):: Ile DGFFLGVVFK (85% 8Å match)
Stachelhaus code match:: 100% (strong)

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1	Ferric Uptake Regulator
MogR	Repressor of flagellar motility genes
NrtR	NAD synthesis repressor
ToxT	Regulator of MSHA biosynthesis

NZ_CP032146.1 - Region 2 - HR-T2PKS

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Location: 649,855 - 692,023 nt. (total: 42,169 nt) Show pHMM detection rules used

HR-T2PKS: (hr-t2pks-ksa and (t2fas or APE_KS2 or ketoacyl-synt))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

D2M30_RS03455: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Hydrolases: amidase

D2M30_RS03395: amidase

smcogs: SMCOG1105: amidase

Ligases: synthase

D2M30_RS03445: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000866.5	0.50	other (other)	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0000888.5	0.48	other (other)	bacilysin	Bacillus sp. CS93
BGC0001184.4	0.46	other (other)	bacilysin	Bacillus velezensis FZB42
BGC0000231.5	0.46	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0002404.2	0.46	other (other)	falcarindiol	Solanum lycopersicum
BGC0001987.2	0.46	PKS	koreenceine A, koreenceine B, koreenceine C, koreenceine D	Pseudomonas koreensis
BGC0001197.5	0.45	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000948.5	0.45	other (other)	α-galactosylceramide	Bacteroides fragilis NCTC 9343
BGC0000204.5	0.44	PKS	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200
BGC0000234.5	0.44	PKS	jadomycin	Streptomyces venezuelae ATCC 10712

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000866.5	0.50	other (other)	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0000888.5	0.48	other (other)	bacilysin	Bacillus sp. CS93
BGC0001184.4	0.46	other (other)	bacilysin	Bacillus velezensis FZB42
BGC0000231.5	0.46	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0002404.2	0.46	other (other)	falcarindiol	Solanum lycopersicum
BGC0001987.2	0.46	PKS	koreenceine A, koreenceine B, koreenceine C, koreenceine D	Pseudomonas koreensis
BGC0001197.5	0.45	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000948.5	0.45	other (other)	α-galactosylceramide	Bacteroides fragilis NCTC 9343
BGC0000204.5	0.44	PKS	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200
BGC0000234.5	0.44	PKS	jadomycin	Streptomyces venezuelae ATCC 10712

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.58 out of 21.84

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.63 out of 27.78

Confidence: medium

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.57 out of 26.33

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16

Confidence: strong

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.63 out of 26.85

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.72 out of 29.38

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 25.16 out of 28.19

Confidence: strong

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.73 out of 28.19

Confidence: medium

Additional weak hits (8):

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.98 out of 27.55

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.06 out of 26.33

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.41 out of 30.11

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 23.52 out of 33.73

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.81 out of 31.73

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.43 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.26 out of 32.74

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.19 out of 32.93

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
AbrC3	Antibiotic production activator
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1	Ferric Uptake Regulator
MexT	Global virulence regulator
RutR	Regulator of the pyrimidine and purine metabolism
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_CP032146.1 - Region 3 - lanthipeptide-class-iii

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Location: 774,243 - 796,840 nt. (total: 22,598 nt) Show pHMM detection rules used

lanthipeptide-class-iii: (micKC and not PKS_KS)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

D2M30_RS04035: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Hydrolases: protease

D2M30_RS03990: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Ligases: synthase

D2M30_RS04025: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001535.3	0.76	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0002700.2	0.54	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0002111.3	0.51	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0001226.4	0.49	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0000563.4	0.49	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0000551.5	0.48	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000501.3	0.48	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000519.4	0.48	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000504.5	0.47	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000496.5	0.46	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001535.3	0.76	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0002700.2	0.54	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0002111.3	0.51	ribosomal	andalusicin A, andalusicin B	Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0001226.4	0.49	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0000563.4	0.49	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0000551.5	0.48	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0000501.3	0.48	ribosomal	catenulipeptin	Catenulispora acidiphila DSM 44928
BGC0000519.4	0.48	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000504.5	0.47	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000496.5	0.46	ribosomal	AmfS	Streptomyces griseus subsp. griseus NBRC 13350

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for D2M30_RS04000

D2M30_RS20755

Leader:

MKDVLELQQLNEGTEVEASKGKGG

Core:

LLTLITTIVGSSTISNNC

Core with dehydrations:

LLDhbLIDhbDhbIVGDhaDhaDhbIDhaNNCys

antiSMASH-DB 4.0 matches for D2M30_RS20755

100.0%

NC_014551.1and 5 others:

NC_017188.1 Lanthipeptides: BAMTA208_RS20930_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20755_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03870_lanthipeptideNZ_DF836084.1 Lanthipeptides: CMW1_RS20395_lanthipeptideNZ_KQ236689.1 Lanthipeptides: AD710_RS19840_lanthipeptide

Lanthipeptides: BAMF_RS41655_lanthipeptide

1

LLTLITTIVGSSTISNNC

18

LLTLITTIVGSSTISNNC

1

LLTLITTIVGSSTISNNC

18

94.4%

NZ_CP026010.1and 18 others:

NZ_CP026010.1 Lanthipeptides: BS11774_RS22085_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21825_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21845_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04850_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04870_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19020_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19000_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21910_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21930_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21925_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21920_lanthipeptideNZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19790_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18865_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18885_lanthipeptideNZ_JALAVZ010000001.1 Lanthipeptides: MOF00_RS00410_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19490_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19510_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19505_lanthipeptide

Lanthipeptides: BS11774_RS22075_lanthipeptide

1

LLTLITTIVGSSTISNNC

18

LLTLITTIVG+STISNNC

1

LLTLITTIVGTSTISNNC

18

88.9%

NC_014551.1and 27 others:

NC_014551.1 Lanthipeptides: BAMF_RS41675_lanthipeptideNC_014551.1 Lanthipeptides: BAMF_RS41665_lanthipeptideNC_017188.1 Lanthipeptides: BAMTA208_RS20945_lanthipeptideNC_017188.1 Lanthipeptides: BAMTA208_RS20950_lanthipeptideNC_017188.1 Lanthipeptides: BAMTA208_RS20940_lanthipeptideNZ_CP026010.1 Lanthipeptides: BS11774_RS22090_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20770_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20775_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20765_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21840_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21835_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04865_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04860_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03885_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03890_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03880_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19010_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19005_lanthipeptideNZ_DF836084.1 Lanthipeptides: CMW1_RS20380_lanthipeptideNZ_DF836084.1 Lanthipeptides: CMW1_RS20385_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18880_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18875_lanthipeptideNZ_JALAUK010000033.1 Lanthipeptides: MOE38_RS18580_lanthipeptideNZ_JALAVZ010000001.1 Lanthipeptides: MOF00_RS00405_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19500_lanthipeptideNZ_KQ236689.1 Lanthipeptides: AD710_RS19860_lanthipeptideNZ_KQ236689.1 Lanthipeptides: AD710_RS19855_lanthipeptide

Lanthipeptides: BAMF_RS41670_lanthipeptide

1

LLTLITTIVGSSTISNNC

18

LLTLITT+VG+STISNNC

1

LLTLITTVVGTSTISNNC

18

with 12 more sequence matches

Only the first 10 are displayed here.

50.0%

NC_014551.1and 13 others:

NC_017188.1 Lanthipeptides: BAMTA208_RS20935_lanthipeptideNZ_CP026010.1 Lanthipeptides: BS11774_RS22080_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20760_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21830_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04855_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03875_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19015_lanthipeptideNZ_DF836084.1 Lanthipeptides: CMW1_RS20390_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21915_lanthipeptideNZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19785_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18870_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19495_lanthipeptideNZ_KQ236689.1 Lanthipeptides: AD710_RS19845_lanthipeptide

Lanthipeptides: BAMF_RS41660_lanthipeptide

2

LTLITTIVGSSTISNNC

18

TL+TT++G+STISN+C

4

WTLLTTLIGTSTISNSC

20

50.0%

NZ_LN868937.1and 1 other:

NZ_LN868937.1 Lanthipeptides: BN2144_RS20095_lanthipeptide

Lanthipeptides: BN2144_RS20100_lanthipeptide

1

LLTLITTIVGSSTISNNC

18

T+ TT++G+STISNNC

4

WYTIFTTLIGTSTISNNC

21

45.0%

Lanthipeptides: JVX89_RS12320_lanthipeptide

7

TIVGSSTISNNC

18

T VG STISN C

9

TTVGLSTISNGC

20

40.9%

Lanthipeptides: BN2144_RS19915_lanthipeptide

1

LLTLITTIVGSSTISNNC

18

T +T +V +STISN+C

5

WFTSVTLLVTTSTISNHC

22

36.4%

Lanthipeptides: JGZ56_RS07825_lanthipeptide

2

LTLITTIVGSSTISNNC

18

L+ + + +G STISN+C

6

LSTLLSFLGGSTISNHC

22

34.8%

NZ_CP035727.2and 5 others:

NZ_CP035727.2 Lanthipeptides: EVG22_RS16230_lanthipeptideNZ_CP035727.2 Lanthipeptides: EVG22_RS16225_lanthipeptideNZ_CP035727.2 Lanthipeptides: EVG22_RS16220_lanthipeptideNZ_CP035727.2 Lanthipeptides: EVG22_RS16215_lanthipeptideNZ_CP035727.2 Lanthipeptides: EVG22_RS16210_lanthipeptide

Lanthipeptides: EVG22_RS16235_lanthipeptide

9

VGSSTISNNC

18

V +STISNNC

14

VWASTISNNC

23

33.3%

NZ_BMVC01000018.1and 6 others:

NZ_BMVC01000018.1 Lanthipeptides: IE282_RS34445_lanthipeptideNZ_BMVC01000018.1 Lanthipeptides: IE282_RS34455_lanthipeptideNZ_FOHE01000012.1 Lanthipeptides: BMX40_RS20340_lanthipeptideNZ_JALMDK010000006.1 Lanthipeptides: MZC64_RS26320_lanthipeptideNZ_JANBBG010000004.1 Lanthipeptides: allorf_1567890_1567982_lanthipeptideNZ_JANBBG010000004.1 Lanthipeptides: allorf_1567737_1567829_lanthipeptide

Lanthipeptides: IE282_RS34450_lanthipeptide

12

STISNNC

18

ST+SNNC

3

STVSNNC

9

30.8%

NZ_CP003923.1and 4 others:

NZ_CP042163.1 Lanthipeptides: FPV17_RS21685_lanthipeptideNZ_CP117834.1 Lanthipeptides: PQ477_RS10640_lanthipeptideNZ_KV917380.1 Lanthipeptides: BK583_RS20905_lanthipeptideNZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20340_lanthipeptide

Lanthipeptides: BLEG1_RS21170_lanthipeptide

2

LTLITTIVGSSTISNNC

18

+T T++G ST SN+C

10

ITTTRTVIGWSTASNSC

26

30.4%

NZ_CP014806.1and 3 others:

NZ_CP014806.1 Lanthipeptides: ATY39_RS17975_lanthipeptideNZ_CP014806.1 Lanthipeptides: ATY39_RS17970_lanthipeptideNZ_CP014806.1 Lanthipeptides: ATY39_RS17965_lanthipeptide

Lanthipeptides: ATY39_RS17980_lanthipeptide

9

VGSSTISNNC

18

V +STISN+C

14

VFASTISNHC

23

30.4%

NZ_CP035727.2:

Lanthipeptides: EVG22_RS16240_lanthipeptide

11

SSTISNNC

18

+STISNNC

16

ASTISNNC

23

MIBiG 4.0 matches for D2M30_RS20755

34.8%

Lanthipeptide: andalusicin A or andalusicin B

9

VGSSTISNNC

18

V +STISNNC

14

VWASTISNNC

23

30.4%

Lanthipeptide: andalusicin A or andalusicin B

11

SSTISNNC

18

+STISNNC

16

ASTISNNC

23

D2M30_RS20760

Leader:

MNEVLELQQLSKGSEVE

Core:

TAGWTLLTTLIGTSTISNSCNK

Core with dehydrations:

DhbAGWDhbLLDhbDhbLIGDhbDhaDhbIDhaNDhaCysNK

antiSMASH-DB 4.0 matches for D2M30_RS20760

100.0%

NC_014551.1and 13 others:

NC_017188.1 Lanthipeptides: BAMTA208_RS20935_lanthipeptideNZ_CP026010.1 Lanthipeptides: BS11774_RS22080_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20760_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21830_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04855_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03875_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19015_lanthipeptideNZ_DF836084.1 Lanthipeptides: CMW1_RS20390_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21915_lanthipeptideNZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19785_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18870_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19495_lanthipeptideNZ_KQ236689.1 Lanthipeptides: AD710_RS19845_lanthipeptide

Lanthipeptides: BAMF_RS41660_lanthipeptide

1

TAGWTLLTTLIGTSTISNSCNK

22

TAGWTLLTTLIGTSTISNSCNK

1

TAGWTLLTTLIGTSTISNSCNK

22

63.6%

Lanthipeptides: BN2144_RS19915_lanthipeptide

1

TAGW--TLLTTLIGTSTISNSC

20

TAGW T +T L+ TSTISN C

1

TAGWWFTSVTLLVTTSTISNHC

22

60.9%

Lanthipeptides: BN2144_RS20095_lanthipeptide

4

WTLLTTLIGTSTISNSCNK

22

+T+ TTLIGTSTISN+C K

5

YTIFTTLIGTSTISNNCGK

23

with 10 more sequence matches

59.1%

Lanthipeptides: BN2144_RS20100_lanthipeptide

4

WTLLTTLIGTSTISNSC

20

+T+ TTLIGTSTISN+C

5

YTIFTTLIGTSTISNNC

21

54.5%

NC_014551.1and 27 others:

NC_014551.1 Lanthipeptides: BAMF_RS41665_lanthipeptideNC_014551.1 Lanthipeptides: BAMF_RS41670_lanthipeptideNC_017188.1 Lanthipeptides: BAMTA208_RS20950_lanthipeptideNC_017188.1 Lanthipeptides: BAMTA208_RS20940_lanthipeptideNC_017188.1 Lanthipeptides: BAMTA208_RS20945_lanthipeptideNZ_CP026010.1 Lanthipeptides: BS11774_RS22090_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20775_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20765_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20770_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21840_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21835_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04865_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04860_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03890_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03880_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03885_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19010_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19005_lanthipeptideNZ_DF836084.1 Lanthipeptides: CMW1_RS20385_lanthipeptideNZ_DF836084.1 Lanthipeptides: CMW1_RS20380_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18880_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18875_lanthipeptideNZ_JALAUK010000033.1 Lanthipeptides: MOE38_RS18580_lanthipeptideNZ_JALAVZ010000001.1 Lanthipeptides: MOF00_RS00405_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19500_lanthipeptideNZ_KQ236689.1 Lanthipeptides: AD710_RS19860_lanthipeptideNZ_KQ236689.1 Lanthipeptides: AD710_RS19855_lanthipeptide

Lanthipeptides: BAMF_RS41675_lanthipeptide

4

WTLLTTLIGTSTISNSC

20

TL+TT++GTSTISN+C

2

LTLITTVVGTSTISNNC

18

54.5%

NZ_CP026010.1and 18 others:

NZ_CP026010.1 Lanthipeptides: BS11774_RS22085_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21825_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21845_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04850_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04870_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19020_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19000_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21910_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21930_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21925_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21920_lanthipeptideNZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19790_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18865_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18885_lanthipeptideNZ_JALAVZ010000001.1 Lanthipeptides: MOF00_RS00410_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19490_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19510_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19505_lanthipeptide

Lanthipeptides: BS11774_RS22075_lanthipeptide

4

WTLLTTLIGTSTISNSC

20

TL+TT++GTSTISN+C

2

LTLITTIVGTSTISNNC

18

50.0%

NC_014551.1and 5 others:

NC_017188.1 Lanthipeptides: BAMTA208_RS20930_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20755_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03870_lanthipeptideNZ_DF836084.1 Lanthipeptides: CMW1_RS20395_lanthipeptideNZ_KQ236689.1 Lanthipeptides: AD710_RS19840_lanthipeptide

Lanthipeptides: BAMF_RS41655_lanthipeptide

4

WTLLTTLIGTSTISNSC

20

TL+TT++G+STISN+C

2

LTLITTIVGSSTISNNC

18

50.0%

Lanthipeptides: JVX89_RS12320_lanthipeptide

3

GWTLLT-TLIGTSTISNSC

20

G+T T T +G STISN C

2

GYTPTTVTTVGLSTISNGC

20

40.9%

Lanthipeptides: JGZ56_RS07825_lanthipeptide

3

GWTLLTTLIGTSTISNSC

20

G + L + +G STISN C

5

GLSTLLSFLGGSTISNHC

22

40.9%

NZ_FOHE01000012.1and 1 other:

NZ_FOHE01000012.1 Lanthipeptides: BMX40_RS20540_lanthipeptide

Lanthipeptides: BMX40_RS20545_lanthipeptide

3

GWTLLTTLIGTSTISNSC

20

GWT T+ ST+SN C

2

GWTWTVTIF-LSTVSNHC

18

34.6%

NZ_CP003923.1and 4 others:

NZ_CP042163.1 Lanthipeptides: FPV17_RS21685_lanthipeptideNZ_CP117834.1 Lanthipeptides: PQ477_RS10640_lanthipeptideNZ_KV917380.1 Lanthipeptides: BK583_RS20905_lanthipeptideNZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20340_lanthipeptide

Lanthipeptides: BLEG1_RS21170_lanthipeptide

9

TLIGTSTISNSC

20

T+IG ST SNSC

15

TVIGWSTASNSC

26

33.3%

BGC0000563.4 (AEA03263.1):

Lanthipeptides: allorf_1652598_1652744_lanthipeptide

9

TLIGTSTISNSCNK

22

T+ G STISN CNK

14

TVYGLSTISNKCNK

27

17.2%

NZ_FOHE01000012.1:

Lanthipeptides: BMX40_RS20340_lanthipeptide

14

STISNSCNK

22

ST+SN+C++

19

STVSNNCDR

27

MIBiG 4.0 matches for D2M30_RS20760

31.8%

Lanthipeptide: venezuelin

7

LTTLIGTSTISNSC

20

L TL+ T I SC

8

LLTLLNTVCIGISC

21

26.1%

Lanthipeptide: andalusicin A or andalusicin B

13

TSTISNSC

20

STISN+C

16

ASTISNNC

23

26.1%

Lanthipeptide: andalusicin A or andalusicin B

14

STISNSC

20

STISN+C

17

STISNNC

23

D2M30_RS20765

Leader:

MRDVLELQQLNEGTEVEASKGKGG

D2M30_RS20775

Leader:

MKDVLELQQLNEGTEVEASKGKGG

Shared core:

LLTLITTVVGTSTISNNCG

Core with dehydrations:

LLDhbLIDhbDhbVVGDhbDhaDhbIDhaNNCysG

antiSMASH-DB 4.0 matches for D2M30_RS20765

100.0%

NC_014551.1and 21 others:

NC_014551.1 Lanthipeptides: BAMF_RS41665_lanthipeptideNC_017188.1 Lanthipeptides: BAMTA208_RS20950_lanthipeptideNC_017188.1 Lanthipeptides: BAMTA208_RS20940_lanthipeptideNZ_CP026010.1 Lanthipeptides: BS11774_RS22090_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20775_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20765_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21840_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21835_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04865_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04860_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03890_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03880_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19010_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19005_lanthipeptideNZ_DF836084.1 Lanthipeptides: CMW1_RS20385_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18880_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18875_lanthipeptideNZ_JALAVZ010000001.1 Lanthipeptides: MOF00_RS00405_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19500_lanthipeptideNZ_KQ236689.1 Lanthipeptides: AD710_RS19860_lanthipeptideNZ_KQ236689.1 Lanthipeptides: AD710_RS19855_lanthipeptide

Lanthipeptides: BAMF_RS41675_lanthipeptide

1

LLTLITTVVGTSTISNNCG

19

LLTLITTVVGTSTISNNCG

1

LLTLITTVVGTSTISNNCG

19

94.7%

NC_014551.1and 5 others:

NC_017188.1 Lanthipeptides: BAMTA208_RS20945_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20770_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03885_lanthipeptideNZ_DF836084.1 Lanthipeptides: CMW1_RS20380_lanthipeptideNZ_JALAUK010000033.1 Lanthipeptides: MOE38_RS18580_lanthipeptide

Lanthipeptides: BAMF_RS41670_lanthipeptide

1

LLTLITTVVGTSTISNNC

18

LLTLITTVVGTSTISNNC

1

LLTLITTVVGTSTISNNC

18

94.7%

NZ_CP026010.1and 9 others:

NZ_CP054584.1 Lanthipeptides: HT135_RS21845_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04870_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19000_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21930_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21925_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21920_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18885_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19510_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19505_lanthipeptide

Lanthipeptides: BS11774_RS22085_lanthipeptide

1

LLTLITTVVGTSTISNNCG

19

LLTLITT+VGTSTISNNCG

1

LLTLITTIVGTSTISNNCG

19

with 22 more sequence matches

Only the first 10 are displayed here.

89.5%

NZ_CP026010.1and 8 others:

NZ_CP054584.1 Lanthipeptides: HT135_RS21825_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04850_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19020_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21910_lanthipeptideNZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19790_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18865_lanthipeptideNZ_JALAVZ010000001.1 Lanthipeptides: MOF00_RS00410_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19490_lanthipeptide

Lanthipeptides: BS11774_RS22075_lanthipeptide

1

LLTLITTVVGTSTISNNC

18

LLTLITT+VGTSTISNNC

1

LLTLITTIVGTSTISNNC

18

84.2%

NC_014551.1and 5 others:

NC_017188.1 Lanthipeptides: BAMTA208_RS20930_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20755_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03870_lanthipeptideNZ_DF836084.1 Lanthipeptides: CMW1_RS20395_lanthipeptideNZ_KQ236689.1 Lanthipeptides: AD710_RS19840_lanthipeptide

Lanthipeptides: BAMF_RS41655_lanthipeptide

1

LLTLITTVVGTSTISNNC

18

LLTLITT+VG+STISNNC

1

LLTLITTIVGSSTISNNC

18

56.5%

Lanthipeptides: BN2144_RS20095_lanthipeptide

1

LLTLITTVVGTSTISNNCG

19

T+ TT++GTSTISNNCG

4

WYTIFTTLIGTSTISNNCG

22

54.5%

NC_014551.1and 13 others:

NC_017188.1 Lanthipeptides: BAMTA208_RS20935_lanthipeptideNZ_CP026010.1 Lanthipeptides: BS11774_RS22080_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20760_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21830_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04855_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03875_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19015_lanthipeptideNZ_DF836084.1 Lanthipeptides: CMW1_RS20390_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21915_lanthipeptideNZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19785_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18870_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19495_lanthipeptideNZ_KQ236689.1 Lanthipeptides: AD710_RS19845_lanthipeptide

Lanthipeptides: BAMF_RS41660_lanthipeptide

2

LTLITTVVGTSTISNNC

18

TL+TT++GTSTISN+C

4

WTLLTTLIGTSTISNSC

20

54.5%

Lanthipeptides: BN2144_RS20100_lanthipeptide

1

LLTLITTVVGTSTISNNC

18

T+ TT++GTSTISNNC

4

WYTIFTTLIGTSTISNNC

21

45.5%

Lanthipeptides: BN2144_RS19915_lanthipeptide

1

LLTLITTVVGTSTISNNC

18

T +T +V TSTISN+C

5

WFTSVTLLVTTSTISNHC

22

45.0%

Lanthipeptides: JVX89_RS12320_lanthipeptide

7

TVVGTSTISNNC

18

T VG STISN C

9

TTVGLSTISNGC

20

36.8%

NC_016109.1and 5 others:

NC_016109.1 Lanthipeptides: KSE_RS43700_lanthipeptideNZ_CP068437.1 Lanthipeptides: JK628_RS03400_lanthipeptideNZ_CP068437.1 Lanthipeptides: JK628_RS03395_lanthipeptideNZ_CP068437.1 Lanthipeptides: allorf_0778008_0778106_lanthipeptideNZ_CP068437.1 Lanthipeptides: JK628_RS03405_lanthipeptide

Lanthipeptides: KSE_RS43695_lanthipeptide

12

STISNNCG

19

STISN+CG

2

STISNHCG

9

36.8%

NC_016109.1:

Lanthipeptides: KSE_RS43705_lanthipeptide

12

STISNNCG

19

STISN CG

2

STISNYCG

9

36.8%

NZ_BMVC01000018.1and 1 other:

NZ_BMVC01000018.1 Lanthipeptides: IE282_RS34445_lanthipeptide

Lanthipeptides: IE282_RS34450_lanthipeptide

12

STISNNCG

19

ST+SNNCG

3

STVSNNCG

10

MIBiG 4.0 matches for D2M30_RS20765

34.8%

Lanthipeptide: andalusicin A or andalusicin B

9

VGTSTISNNC

18

V STISNNC

14

VWASTISNNC

23

30.4%

Lanthipeptide: andalusicin A or andalusicin B

11

TSTISNNC

18

STISNNC

16

ASTISNNC

23

D2M30_RS20770

Leader:

MRDVLELQQLNEGTEVEASKGKGG

Core:

LLTLITTVVGTSTISNNC

Core with dehydrations:

LLDhbLIDhbDhbVVGDhbDhaDhbIDhaNNCys

antiSMASH-DB 4.0 matches for D2M30_RS20770

100.0%

NC_014551.1and 27 others:

NC_014551.1 Lanthipeptides: BAMF_RS41675_lanthipeptideNC_014551.1 Lanthipeptides: BAMF_RS41665_lanthipeptideNC_017188.1 Lanthipeptides: BAMTA208_RS20945_lanthipeptideNC_017188.1 Lanthipeptides: BAMTA208_RS20950_lanthipeptideNC_017188.1 Lanthipeptides: BAMTA208_RS20940_lanthipeptideNZ_CP026010.1 Lanthipeptides: BS11774_RS22090_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20770_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20775_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20765_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21840_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21835_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04865_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04860_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03885_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03890_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03880_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19010_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19005_lanthipeptideNZ_DF836084.1 Lanthipeptides: CMW1_RS20380_lanthipeptideNZ_DF836084.1 Lanthipeptides: CMW1_RS20385_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18880_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18875_lanthipeptideNZ_JALAUK010000033.1 Lanthipeptides: MOE38_RS18580_lanthipeptideNZ_JALAVZ010000001.1 Lanthipeptides: MOF00_RS00405_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19500_lanthipeptideNZ_KQ236689.1 Lanthipeptides: AD710_RS19860_lanthipeptideNZ_KQ236689.1 Lanthipeptides: AD710_RS19855_lanthipeptide

Lanthipeptides: BAMF_RS41670_lanthipeptide

1

LLTLITTVVGTSTISNNC

18

LLTLITTVVGTSTISNNC

1

LLTLITTVVGTSTISNNC

18

89.5%

NZ_CP026010.1and 18 others:

NZ_CP026010.1 Lanthipeptides: BS11774_RS22075_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21845_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21825_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04870_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04850_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19000_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19020_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21930_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21925_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21920_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21910_lanthipeptideNZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19790_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18885_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18865_lanthipeptideNZ_JALAVZ010000001.1 Lanthipeptides: MOF00_RS00410_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19510_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19505_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19490_lanthipeptide

Lanthipeptides: BS11774_RS22085_lanthipeptide

1

LLTLITTVVGTSTISNNC

18

LLTLITT+VGTSTISNNC

1

LLTLITTIVGTSTISNNC

18

88.9%

NC_014551.1and 5 others:

NC_017188.1 Lanthipeptides: BAMTA208_RS20930_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20755_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03870_lanthipeptideNZ_DF836084.1 Lanthipeptides: CMW1_RS20395_lanthipeptideNZ_KQ236689.1 Lanthipeptides: AD710_RS19840_lanthipeptide

Lanthipeptides: BAMF_RS41655_lanthipeptide

1

LLTLITTVVGTSTISNNC

18

LLTLITT+VG+STISNNC

1

LLTLITTIVGSSTISNNC

18

with 13 more sequence matches

Only the first 10 are displayed here.

54.5%

NC_014551.1and 13 others:

NC_017188.1 Lanthipeptides: BAMTA208_RS20935_lanthipeptideNZ_CP026010.1 Lanthipeptides: BS11774_RS22080_lanthipeptideNZ_CP032146.1 Lanthipeptides: D2M30_RS20760_lanthipeptideNZ_CP054584.1 Lanthipeptides: HT135_RS21830_lanthipeptideNZ_CP061284.1 Lanthipeptides: ICJ61_RS04855_lanthipeptideNZ_CP062984.1 Lanthipeptides: IL989_RS03875_lanthipeptideNZ_CP065858.1 Lanthipeptides: I7X10_RS19015_lanthipeptideNZ_DF836084.1 Lanthipeptides: CMW1_RS20390_lanthipeptideNZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21915_lanthipeptideNZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19785_lanthipeptideNZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18870_lanthipeptideNZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19495_lanthipeptideNZ_KQ236689.1 Lanthipeptides: AD710_RS19845_lanthipeptide

Lanthipeptides: BAMF_RS41660_lanthipeptide

2

LTLITTVVGTSTISNNC

18

TL+TT++GTSTISN+C

4

WTLLTTLIGTSTISNSC

20

52.2%

NZ_LN868937.1and 1 other:

NZ_LN868937.1 Lanthipeptides: BN2144_RS20100_lanthipeptide

Lanthipeptides: BN2144_RS20095_lanthipeptide

1

LLTLITTVVGTSTISNNC

18

T+ TT++GTSTISNNC

4

WYTIFTTLIGTSTISNNC

21

45.5%

Lanthipeptides: BN2144_RS19915_lanthipeptide

1

LLTLITTVVGTSTISNNC

18

T +T +V TSTISN+C

5

WFTSVTLLVTTSTISNHC

22

45.0%

Lanthipeptides: JVX89_RS12320_lanthipeptide

7

TVVGTSTISNNC

18

T VG STISN C

9

TTVGLSTISNGC

20

36.4%

Lanthipeptides: JGZ56_RS07825_lanthipeptide

2

LTLITTVVGTSTISNNC

18

L+ + + +G STISN+C

6

LSTLLSFLGGSTISNHC

22

34.8%

NZ_CP035727.2and 5 others:

NZ_CP035727.2 Lanthipeptides: EVG22_RS16230_lanthipeptideNZ_CP035727.2 Lanthipeptides: EVG22_RS16225_lanthipeptideNZ_CP035727.2 Lanthipeptides: EVG22_RS16220_lanthipeptideNZ_CP035727.2 Lanthipeptides: EVG22_RS16215_lanthipeptideNZ_CP035727.2 Lanthipeptides: EVG22_RS16210_lanthipeptide

Lanthipeptides: EVG22_RS16235_lanthipeptide

9

VGTSTISNNC

18

V STISNNC

14

VWASTISNNC

23

34.6%

NZ_CP003923.1and 4 others:

NZ_CP042163.1 Lanthipeptides: FPV17_RS21685_lanthipeptideNZ_CP117834.1 Lanthipeptides: PQ477_RS10640_lanthipeptideNZ_KV917380.1 Lanthipeptides: BK583_RS20905_lanthipeptideNZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20340_lanthipeptide

Lanthipeptides: BLEG1_RS21170_lanthipeptide

2

LTLITTVVGTSTISNNC

18

+T TV+G ST SN+C

10

ITTTRTVIGWSTASNSC

26

33.3%

NZ_BMVC01000018.1and 6 others:

NZ_BMVC01000018.1 Lanthipeptides: IE282_RS34445_lanthipeptideNZ_BMVC01000018.1 Lanthipeptides: IE282_RS34455_lanthipeptideNZ_FOHE01000012.1 Lanthipeptides: BMX40_RS20340_lanthipeptideNZ_JALMDK010000006.1 Lanthipeptides: MZC64_RS26320_lanthipeptideNZ_JANBBG010000004.1 Lanthipeptides: allorf_1567890_1567982_lanthipeptideNZ_JANBBG010000004.1 Lanthipeptides: allorf_1567737_1567829_lanthipeptide

Lanthipeptides: IE282_RS34450_lanthipeptide

12

STISNNC

18

ST+SNNC

3

STVSNNC

9

33.3%

NZ_CP068437.1and 1 other:

NZ_CP068437.1 Lanthipeptides: JK628_RS03395_lanthipeptide

Lanthipeptides: JK628_RS03400_lanthipeptide

12

STISNNC

18

STISN+C

5

STISNHC

11

31.6%

NZ_CP014222.1:

Lanthipeptides: VN23_RS10390_lanthipeptide

7

TVVGTSTISNNC

18

V ST+SN+C

2

QVADWSTVSNHC

13

MIBiG 4.0 matches for D2M30_RS20770

34.8%

Lanthipeptide: andalusicin A or andalusicin B

9

VGTSTISNNC

18

V STISNNC

14

VWASTISNNC

23

30.4%

Lanthipeptide: andalusicin A or andalusicin B

11

TSTISNNC

18

STISNNC

16

ASTISNNC

23

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 18.25 out of 18.46

Confidence: strong

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.33 out of 30.25

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.90 out of 28.19

Confidence: medium

Additional weak hits (2):

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.23 out of 23.43

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.73 out of 29.38

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

D2M30_RS20755 - Class III

Cleavage pHMM score: 0.00

RODEO score: 0

Monoisotopic mass: 1723.0 Da

Molecular weight: 1724.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1742.0 Da N = 1; 1760.0 Da N = 2; 1778.1 Da N = 3; 1796.1 Da N = 4; 1814.1 Da N = 5; 1832.1 Da N = 6

D2M30_RS20760 - Class III

Cleavage pHMM score: -1.30

RODEO score: 0

Monoisotopic mass: 2119.2 Da

Molecular weight: 2120.4 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2138.4 Da N = 1; 2156.4 Da N = 2; 2174.4 Da N = 3; 2192.5 Da N = 4; 2210.5 Da N = 5; 2228.5 Da N = 6; 2246.5 Da N = 7; 2264.5 Da N = 8

D2M30_RS20765 - Class III

Cleavage pHMM score: 0.00

RODEO score: 0

Monoisotopic mass: 1780.0 Da

Molecular weight: 1781.1 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1799.1 Da N = 1; 1817.1 Da N = 2; 1835.1 Da N = 3; 1853.1 Da N = 4; 1871.2 Da N = 5; 1889.2 Da N = 6

D2M30_RS20770 - Class III

Cleavage pHMM score: 0.00

RODEO score: 0

Monoisotopic mass: 1723.0 Da

Molecular weight: 1724.0 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1742.0 Da N = 1; 1760.0 Da N = 2; 1778.1 Da N = 3; 1796.1 Da N = 4; 1814.1 Da N = 5; 1832.1 Da N = 6

D2M30_RS20775 - Class III

Cleavage pHMM score: 0.00

RODEO score: 0

Monoisotopic mass: 1780.0 Da

Molecular weight: 1781.1 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1799.1 Da N = 1; 1817.1 Da N = 2; 1835.1 Da N = 3; 1853.1 Da N = 4; 1871.2 Da N = 5; 1889.2 Da N = 6

TFBS definitions

Regulator	Description
ColR	Phenol-responsive regulator
RpoN	Regulator of nitrogen assimilation and virulence
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_CP032146.1 - Region 4 - PKS-like

Download region SVG

Location: 915,929 - 957,173 nt. (total: 41,245 nt) Show pHMM detection rules used

PKS-like: (t2pks2 or ksIII)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

D2M30_RS04755: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acyltransferase aminotransferase

D2M30_RS04785: acyltransferase

smcogs: SMCOG1141: acyltransferase

D2M30_RS04800: aminotransferase

smcogs: SMCOG1019: aminotransferase

Hydrolases: deacetylase

D2M30_RS04845: polysaccharide deacetylase

smcogs: SMCOG1235: polysaccharide deacetylase

Ligases: synthase

D2M30_RS04805: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Translocases: permease

D2M30_RS04760: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002276.2	0.55	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0002404.2	0.45	other (other)	falcarindiol	Solanum lycopersicum
BGC0002294.3	0.43	other (other)	streptozotocin	Streptomyces achromogenes subsp. streptozoticus
BGC0000205.3	0.43	PKS	bryostatin	Candidatus Endobugula sertula
BGC0001292.5	0.42	other (other)	A33853	Streptomyces sp. NRRL 12068
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0002150.2	0.42	ribosomal	triculamin	Streptomyces triculaminicus
BGC0002151.2	0.42	ribosomal	alboverticillin	Streptomyces griseocarneus
BGC0000623.3	0.42	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001485.4	0.42	other (other)	chuangxinmycin	Actinoplanes tsinanensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002276.2	0.55	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0002404.2	0.45	other (other)	falcarindiol	Solanum lycopersicum
BGC0002294.3	0.43	other (other)	streptozotocin	Streptomyces achromogenes subsp. streptozoticus
BGC0000205.3	0.43	PKS	bryostatin	Candidatus Endobugula sertula
BGC0001292.5	0.42	other (other)	A33853	Streptomyces sp. NRRL 12068
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0002150.2	0.42	ribosomal	triculamin	Streptomyces triculaminicus
BGC0002151.2	0.42	ribosomal	alboverticillin	Streptomyces griseocarneus
BGC0000623.3	0.42	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001485.4	0.42	other (other)	chuangxinmycin	Actinoplanes tsinanensis

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.44 out of 30.25

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.75 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.91 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.88 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.01 out of 26.06

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 24.11 out of 27.55

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.52 out of 26.06

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.44 out of 30.25

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.50 out of 23.79

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.28 out of 26.06

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.02 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.27 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.83 out of 28.19

Confidence: medium

Additional weak hits (13):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.48 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.02 out of 28.14

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.37 out of 30.25

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.46 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.28 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.97 out of 28.14

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 19.83 out of 26.12

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.75 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.41 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.47 out of 26.06

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.63 out of 33.14

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.32 out of 33.14

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.59 out of 30.11

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
GnfM	Regulator of nitrogen-fixation genes
IolR	Regulator of the inositol catabolism
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_CP032146.1 - Region 5 - terpene

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Location: 1,041,867 - 1,062,610 nt. (total: 20,744 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

D2M30_RS05415: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

Transferases: aminotransferase

D2M30_RS05430: aminotransferase

smcogs: SMCOG1019: aminotransferase

Hydrolases: hydrolase

D2M30_RS05390: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002458.3	0.49	NRPS	alazopeptin	Streptacidiphilus griseoplanus
BGC0000885.3	0.47	other (other)	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0000846.5	0.44	other (other)	tabtoxin	Pseudomonas syringae
BGC0001880.3	0.43	ribosomal	scytodecamide	Scytonema sp. UIC 10036
BGC0001374.5	0.43	other (other)	thienodolin	Streptomyces albogriseolus
BGC0000502.5	0.39	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0001488.3	0.39	other (other)	4-formylaminooxyvinylglycine	Pseudomonas fluorescens WH6
BGC0000720.3	0.37	saccharide	tobramycin	Streptoalloteichus tenebrarius
BGC0001810.3	0.37	PKS	trehangelin	Polymorphospora rubra
BGC0001735.5	0.37	other (other)	pentostatine, vidarabine	Streptomyces antibioticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002458.3	0.49	NRPS	alazopeptin	Streptacidiphilus griseoplanus
BGC0000885.3	0.47	other (other)	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0000846.5	0.44	other (other)	tabtoxin	Pseudomonas syringae
BGC0001880.3	0.43	ribosomal	scytodecamide	Scytonema sp. UIC 10036
BGC0001374.5	0.43	other (other)	thienodolin	Streptomyces albogriseolus
BGC0000502.5	0.39	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0001488.3	0.39	other (other)	4-formylaminooxyvinylglycine	Pseudomonas fluorescens WH6
BGC0000720.3	0.37	saccharide	tobramycin	Streptoalloteichus tenebrarius
BGC0001810.3	0.37	PKS	trehangelin	Polymorphospora rubra
BGC0001735.5	0.37	other (other)	pentostatine, vidarabine	Streptomyces antibioticus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene		squalene	C30	acyclic	none
triterpene	C30 carotenoid	diapophytoene	C30	acyclic	none
triterpene		PSPP	C30	acyclic	PP
tetraterpene	C40 carotenoid	phytoene	C40	acyclic	none
triterpene		hydroxysqualene	C30	acyclic	OH

Genes with terpene domains:

D2M30_RS05395: PT_phytoene_like

Domain 1 (4 - 244): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → squalene; FPP → diapophytoene; FPP → PSPP; GGPP → phytoene; PSPP → hydroxysqualene

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 23.16 out of 26.33

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.02 out of 26.06

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.27 out of 28.19

Confidence: medium

Additional weak hits (6):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.05 out of 31.73

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.16 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.08 out of 26.06

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.61 out of 30.22

Confidence: weak

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.99 out of 27.55

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 23.54 out of 35.63

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
PP	Diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_CP032146.1 - Region 6 - transAT-PKS

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Location: 1,384,092 - 1,472,296 nt. (total: 88,205 nt) Show pHMM detection rules used

transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

D2M30_RS07395: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

D2M30_RS07410: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

D2M30_RS07420: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

D2M30_RS07450: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Transferases: acylase kinase

D2M30_RS07275: PfkB domain protein

smcogs: SMCOG1276: PfkB domain protein

D2M30_RS07390: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: deacetylase deformylase hydrolase

D2M30_RS07365: hydrolase

smcogs: SMCOG1179: hydrolase

D2M30_RS07370: peptide deformylase

smcogs: SMCOG1275: peptide deformylase

D2M30_RS07425: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

D2M30_RS07430: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

D2M30_RS07460: polysaccharide deacetylase

smcogs: SMCOG1235: polysaccharide deacetylase

Ligases: synthase

D2M30_RS07400: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

D2M30_RS07440: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

D2M30_RS20910: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000181.5	0.87	PKS	macrolactin H	Bacillus velezensis FZB42
BGC0001383.3	0.86	PKS	macrolactin H, macrolactin B, macrolactin 1c, macrolactin E	Jeotgalibacillus marinus
BGC0001534.3	0.70	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001276.3	0.64	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001164.3	0.64	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001275.3	0.64	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.64	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001160.5	0.64	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0001284.4	0.63	PKS	alternariol	Parastagonospora nodorum SN15

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000181.5	0.87	PKS	macrolactin H	Bacillus velezensis FZB42
BGC0001383.3	0.86	PKS	macrolactin H, macrolactin B, macrolactin 1c, macrolactin E	Jeotgalibacillus marinus
BGC0001534.3	0.70	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001276.3	0.64	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001164.3	0.64	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001275.3	0.64	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.64	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001160.5	0.64	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0001284.4	0.63	PKS	alternariol	Parastagonospora nodorum SN15

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.02 out of 27.78

Confidence: medium

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.94 out of 21.55

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.13 out of 20.97

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.45 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.34 out of 26.06

Confidence: medium

Additional weak hits (12):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.30 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.44 out of 26.06

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.27 out of 30.22

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.65 out of 29.25

Confidence: weak

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.35 out of 26.33

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.39 out of 31.73

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.49 out of 25.75

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.88 out of 26.12

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.49 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.99 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.18 out of 26.06

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.99 out of 33.14

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 6, location 1384091 - 1472296:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (ohmal - ccmal - ccmal) + (ccmal) + (mal) + (ccmal - mal) + (ohmal) + (ohmal - mal)
Non-colinear ordering:: D2M30_RS07395 + D2M30_RS07400 + D2M30_RS20905 + D2M30_RS20910 + D2M30_RS07410 + D2M30_RS07415 + D2M30_RS07420 + D2M30_RS07425

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

D2M30_RS07390: mal

PKS_AT (4..282): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 82.2
Methoxymalonyl-CoA: 28.9
inactive: 28.3
Methylmalonyl-CoA: 19.0
Propionyl-CoA: 13.6
fatty_acid: 11.1
trans-1,2-CPDA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MogR	Repressor of flagellar motility genes

NZ_CP032146.1 - Region 7 - NRPS,T3PKS,transAT-PKS

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Location: 1,690,216 - 1,800,340 nt. (total: 110,125 nt) Show pHMM detection rules used

transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

D2M30_RS08635: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

D2M30_RS08715: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

D2M30_RS08735: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Transferases: acylase

D2M30_RS08675: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

D2M30_RS08680: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

D2M30_RS08685: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: hydrolase protease

D2M30_RS08615: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

D2M30_RS08670: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

D2M30_RS08755: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: hydratase

D2M30_RS08700: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

D2M30_RS08705: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase

D2M30_RS08640: 8-amino-7-oxononanoate synthase

smcogs: SMCOG1109: 8-amino-7-oxononanoate synthase

D2M30_RS08695: hydroxymethylglutaryl-CoA synthase

smcogs: SMCOG1043: hydroxymethylglutaryl-CoA synthase

D2M30_RS08710: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

D2M30_RS08720: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

D2M30_RS08725: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

D2M30_RS08730: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001089.5	1.48	NRPS, PKS	bacillaene	Bacillus velezensis FZB42
BGC0001160.5	1.03	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0002135.2	1.02	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001164.3	1.01	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001135.5	0.97	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001132.4	0.97	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.96	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001833.4	0.96	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.94	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.94	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001089.5	0.87	NRPS, PKS	bacillaene	Bacillus velezensis FZB42
BGC0002135.2	0.69	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001132.4	0.69	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	0.69	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001833.4	0.68	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.68	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.67	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5	0.67	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001758.4	0.66	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001641.4	0.65	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.50 out of 27.78

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.78 out of 20.97

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.85 out of 20.97

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.62 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.60 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.29 out of 27.78

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.30 out of 24.78

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.92 out of 24.78

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.95 out of 28.19

Confidence: medium

Additional weak hits (21):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.51 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.96 out of 26.06

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.16 out of 32.74

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.22 out of 28.14

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.08 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.45 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.06 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.67 out of 26.06

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.62 out of 25.75

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.41 out of 30.25

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.04 out of 30.25

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.58 out of 21.55

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.73 out of 30.25

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.61 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.03 out of 26.06

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.39 out of 30.25

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.54 out of 36.54

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 20.38 out of 28.14

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.62 out of 32.93

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.08 out of 39.62

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 7, location 1690215 - 1800340:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (fatty_acid - Gly - ccmal - ohmal - mal) + (ccmal - mal - ohmal - mal) + (Me-ccmal - ohmal) + (Ala - ccmal - ccmal - Me-ccmal) + (mal - mal)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

D2M30_RS08675: mal

PKS_AT (4..285): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 98.2
inactive: 43.3
Methoxymalonyl-CoA: 36.6
Methylmalonyl-CoA: 24.6
Propionyl-CoA: 24.5
2-Methylbutyryl-CoA: 5.7
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

D2M30_RS08680: mal

PKS_AT (7..293): mal

ATSignature: (unknown)

No matches above 50%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 29.5
inactive: 17.0
Methoxymalonyl-CoA: 11.3
Benzoyl-CoA: 9.4
Isobutyryl-CoA: 8.6
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Methylmalonyl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

D2M30_RS08685: mal

PKS_AT (4..282): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 98.6
inactive: 30.6
Methoxymalonyl-CoA: 27.3
Methylmalonyl-CoA: 14.0
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

D2M30_RS08710: fatty_acid - Gly

Search NORINE for peptide: strict or relaxed

CAL_domain (74..476): fatty_acid

minowa: fatty_acid

Prediction, score:

fatty_acid: 22.2
shikimic_acid: 0.0
NH2: 0.0
Acetyl-CoA: 0.0
AHBA: 0.0

AMP-binding (1145..1540): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FSMTFDIAALELQALCGGEWNMFGPTETTIWSAV
Nearest Stachelhaus code(s):: Gly DILQLGMIWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

D2M30_RS08725: Ala

Search NORINE for peptide: strict or relaxed

AMP-binding (494..898): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: TFLTFDVSISEGNFMVAGEENIYGPTETSIYAAY
Nearest Stachelhaus code(s):: Ala DVSNMAIIYK (88% 8Å match)
Stachelhaus code match:: 100% (strong)

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 2	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_CP032146.1 - Region 8 - NRPS,betalactone,transAT-PKS

Download region SVG

Location: 1,850,564 - 1,987,202 nt. (total: 136,639 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
betalactone: (HMGL-like and AMP-binding)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

D2M30_RS09270: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

D2M30_RS09285: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

D2M30_RS09360: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

D2M30_RS09495: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: acylase aminotransferase carboxylase transferase

D2M30_RS09260: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

D2M30_RS09305: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

D2M30_RS09320: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

D2M30_RS09330: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

D2M30_RS09350: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Hydrolases: peptidase

D2M30_RS09470: gamma-glutamyltranspeptidase

smcogs: SMCOG1274: gamma-glutamyltranspeptidase

Lyases: hydratase

D2M30_RS09335: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase

D2M30_RS09245: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

D2M30_RS09250: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

D2M30_RS09255: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

D2M30_RS09300: 8-amino-7-oxononanoate synthase

smcogs: SMCOG1109: 8-amino-7-oxononanoate synthase

D2M30_RS09340: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

D2M30_RS09355: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

D2M30_RS09375: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

D2M30_RS09380: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

D2M30_RS09385: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

D2M30_RS09390: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

D2M30_RS09395: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001833.4	1.59	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	1.58	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001128.4	1.50	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	1.49	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	1.49	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0002286.3	1.49	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	1.47	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001135.5	1.46	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001095.5	1.45	NRPS	fengycin	Bacillus velezensis FZB42
BGC0000402.4	1.40	NRPS	paenilarvin A, paenilarvin B, paenilarvin C	Paenibacillus larvae subsp. larvae DSM 25430

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001095.5	0.89	NRPS	fengycin	Bacillus velezensis FZB42
BGC0000407.5	0.81	NRPS	plipastatin	Bacillus subtilis subsp. subtilis
BGC0000402.4	0.81	NRPS	paenilarvin A, paenilarvin B, paenilarvin C	Paenibacillus larvae subsp. larvae DSM 25430
BGC0001090.5	0.80	NRPS, PKS	bacillomycin D	Bacillus velezensis FZB42
BGC0001103.5	0.79	NRPS, PKS	mycosubtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001098.5	0.77	NRPS, PKS	iturin	Bacillus subtilis
BGC0001833.4	0.75	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001758.4	0.75	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002135.2	0.74	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002075.3	0.73	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.21 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.82 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.27 out of 27.78

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.12 out of 23.79

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 20.32 out of 20.97

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.95 out of 27.78

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 26.66 out of 28.19

Confidence: strong

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 22.20 out of 24.78

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.30 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.83 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.10 out of 28.19

Confidence: medium

Additional weak hits (17):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.53 out of 30.25

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.22 out of 28.14

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.65 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.75 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.42 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.65 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.15 out of 26.06

Confidence: weak

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.44 out of 20.47

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.35 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.41 out of 29.38

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 22.75 out of 35.63

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.74 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.51 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.53 out of 26.06

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.12 out of 33.14

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 19.67 out of 24.78

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 8, location 1850563 - 1987202:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Glu - D-Orn) + (Tyr - D-Thr) + (Glu - D-X) + (Pro - Gln - D-Tyr) + (Ile) + (fatty_acid - mal - Asn - D-Tyr) + (D-Asn - Gln - Pro - D-Asn) + (Ser)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 9, location 1850563 - 1927809:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (fatty_acid - mal - Asn - D-Tyr) + (D-Asn - Gln - Pro - D-Asn) + (Ser)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 10, location 1909534 - 1987202:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Glu - D-Orn) + (Tyr - D-Thr) + (Glu - D-X) + (Pro - Gln - D-Tyr) + (Ile)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

D2M30_RS09245: Asn - Ser

Search NORINE for peptide: strict or relaxed

AMP-binding (268..663): Asn

nrpys: Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: YWASFDLTVTSTKLIVGGDFNEYGPTETVVGCMI
Nearest Stachelhaus code(s):: Asn DLTKIGEVGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1778..2185): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWMTFDVSVWEWHFFASGEINLYGPTEATIDVSY
Nearest Stachelhaus code(s):: Ser DVWHFSLIDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

D2M30_RS09250: Tyr - Asn - Gln - Pro

Search NORINE for peptide: strict or relaxed

AMP-binding (268..662): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: SWKYFDAFILNGSTVVGGENNEYGPTENSVVSTF
Nearest Stachelhaus code(s):: Tyr DALSVGEVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1778..2173): Asn

nrpys: Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: YWASFDLTVTSTKLIVGGECNEYGPTETVVGCMI
Nearest Stachelhaus code(s):: Asn DLTKIGEVGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3287..3692): Gln

nrpys: Gln

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: gln (Gln)

Stachelhaus prediction details:

Stachelhaus sequence:: LGLAFDASVQQADGLIGGETNVYGPTETCVDASL
Nearest Stachelhaus code(s):: Gln DAQDLGVVDK (100% 8Å match); Ile DAQDLGVVDK (74% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (4334..4730): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: LYEAFDVCYQESFLIAAGEHNHYGPSETHVVTMY
Nearest Stachelhaus code(s):: Pro DVQFIAHVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

D2M30_RS09255: fatty_acid - Asn

Search NORINE for peptide: strict or relaxed

CAL_domain (36..478): fatty_acid

minowa: fatty_acid

Prediction, score:

fatty_acid: 614.1
NH2: 18.8
shikimic_acid: 0.0
Acetyl-CoA: 0.0
AHBA: 0.0

AMP-binding (2956..3351): Asn

nrpys: Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: YWASFDLTVTSTKLIVGGEFNEYGPTETVVGCMI
Nearest Stachelhaus code(s):: Asn DLTKIGEVGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

D2M30_RS09260: mal

PKS_AT (6..291): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 71.0
inactive: 30.7
Methoxymalonyl-CoA: 18.6
Propionyl-CoA: 10.2
Methylmalonyl-CoA: 10.0
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

D2M30_RS09355: X

AMP-binding (12..445): X

nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: NNIVF-GCVLGAHGIMAGSTIAYGQTEASPVITQ
Nearest Stachelhaus code(s):: Z-ahmohOrn FGLHIASTCK (56% 8Å match); Ile DGLFIGIPVK (32% 8Å match)
Stachelhaus code match:: 60% (weak)

D2M30_RS09375: Ile

Search NORINE for peptide: strict or relaxed

AMP-binding (473..866): Ile

nrpys: Ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: ile (Ile)

Stachelhaus prediction details:

Stachelhaus sequence:: LNSGFDAVTFEGFLYVGGEYNIYGPTENTTFSTF
Nearest Stachelhaus code(s):: Ile DAFFYGITFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

D2M30_RS09380: Pro - Gln - Tyr

Search NORINE for peptide: strict or relaxed

AMP-binding (469..866): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: LDQAFDVCYQESFFITAGEHNHYGPSETHVVSTY
Nearest Stachelhaus code(s):: Pro DVQFIAHVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1500..1901): Gln

nrpys: Gln

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: glu (Glu)

Stachelhaus prediction details:

Stachelhaus sequence:: FSLTFDASIWEWHFFAGGETNSYGPTEATVEAAY
Nearest Stachelhaus code(s):: Gln DAWHFGSVEK (100% 8Å match); Glu DAWHFGSVEK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2532..2924): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: TWRFFDGFVTSTIITLAGEANEYGPTENSVATTA
Nearest Stachelhaus code(s):: Tyr DGTITAEVAK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

D2M30_RS09385: Glu - X

Search NORINE for peptide: strict or relaxed

AMP-binding (469..873): Glu

nrpys: Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: glu (Glu)

Stachelhaus prediction details:

Stachelhaus sequence:: FGMSFDASIWQWHFFAGGEIHGYGPTEATVDAAF
Nearest Stachelhaus code(s):: Glu DAWHFGGVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1505..1898): X

nrpys: Ala, Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: LNSSFDVTTFEGWLIIGGEWNGYGPTENTTFSTC
Nearest Stachelhaus code(s):: Ala or Val DVFWIGGTFK (97% 8Å match); Val DVFWIGGTFK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

D2M30_RS09390: Tyr - Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (473..866): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: TWRFFDGSLTSTLITFAGELNEYGPTENSVATTI
Nearest Stachelhaus code(s):: Tyr DGTLTAEVAK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1508..1904): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LHKHFDFSVWEGNQIFGGEVNMYGITETTVHVTC
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

D2M30_RS09395: Glu - Orn

Search NORINE for peptide: strict or relaxed

AMP-binding (464..868): Glu

nrpys: Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: glu (Glu)

Stachelhaus prediction details:

Stachelhaus sequence:: FGMSFDASIWQWHFFAGGEIHGYGPTEATVDAAF
Nearest Stachelhaus code(s):: Glu DAWHFGGVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1500..1905): Orn

nrpys: Orn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: Orn and hydroxy-Orn specific (Orn, OH-Orn)
Single AA prediction:: orn (Orn)

Stachelhaus prediction details:

Stachelhaus sequence:: AAWAFDVFSGDRESVLGSDINSYGVTEATIDSSY
Nearest Stachelhaus code(s):: Orn DVGEVGSIDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
IolR	Regulator of the inositol catabolism
LexA variant 2	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_CP032146.1 - Region 9 - terpene

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Location: 2,020,975 - 2,042,858 nt. (total: 21,884 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

D2M30_RS09745: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

Hydrolases: hydrolase

D2M30_RS09770: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002173.2	0.47	saccharide, terpene	fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol	Aspergillus fumigatus A1163
BGC0001535.3	0.42	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0000313.4	0.36	NRPS	beauvericin	Beauveria bassiana
BGC0002255.3	0.33	PKS	lijiquinone	Ascomycota sp. F53
BGC0000663.5	0.30	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0000686.3	0.30	terpene	helvolic acid	Aspergillus fumigatus Af293
BGC0001575.4	0.29	NRPS	PZN5, PZN6, PZN7, PZN9, PZN10, PZN11	Ruminococcus sp. 5_1_39BFAA
BGC0001338.4	0.28	PKS	citrinin	Monascus ruber
BGC0000154.4	0.28	PKS	stipitatic acid	Talaromyces stipitatus ATCC 10500
BGC0001739.3	0.28	other (other)	phosphonoacetic Acid	Streptomyces sp. NRRL F-525

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002173.2	0.47	saccharide, terpene	fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol	Aspergillus fumigatus A1163
BGC0001535.3	0.42	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0000313.4	0.36	NRPS	beauvericin	Beauveria bassiana
BGC0002255.3	0.33	PKS	lijiquinone	Ascomycota sp. F53
BGC0000663.5	0.30	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0000686.3	0.30	terpene	helvolic acid	Aspergillus fumigatus Af293
BGC0001575.4	0.29	NRPS	PZN5, PZN6, PZN7, PZN9, PZN10, PZN11	Ruminococcus sp. 5_1_39BFAA
BGC0001338.4	0.28	PKS	citrinin	Monascus ruber
BGC0000154.4	0.28	PKS	stipitatic acid	Talaromyces stipitatus ATCC 10500
BGC0001739.3	0.28	other (other)	phosphonoacetic Acid	Streptomyces sp. NRRL F-525

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	hopanoid		C30	hopanoid skeleton	unknown
triterpene	polypodane		C30	polypodane skeleton	unknown

Genes with terpene domains:

D2M30_RS09750: T2TS

Domain 1 (5 - 624): Type 2 terpene synthase

Subtype: Squalene substrate

Reactions:: squalene → hopanoid; squalene → polypodane

Transcription Factor Binding Sites

Binding sites found:

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.14 out of 18.16

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.53 out of 26.06

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.26 out of 27.78

Confidence: medium

Additional weak hits (4):

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.62 out of 21.55

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.67 out of 26.06

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.10 out of 29.25

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.14 out of 39.62

Confidence: weak

Terpene

TFBS Finder

Glossary

No acronyms to display

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis

NZ_CP032146.1 - Region 10 - T3PKS

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Location: 2,097,950 - 2,139,050 nt. (total: 41,101 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: acetyltransferase methyltransferase

D2M30_RS10275: isoprenylcysteine carboxyl methyltransferase

smcogs: SMCOG1150: isoprenylcysteine carboxyl methyltransferase

D2M30_RS10285: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

Ligases: synthase

D2M30_RS10280: chalcone and stilbene synthase domain protein

smcogs: SMCOG1024: chalcone and stilbene synthase domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000282.3	0.55	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3	0.51	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0002332.2	0.44	PKS	4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A	Candidatus Entotheonella sp.
BGC0001475.4	0.43	terpene	aspterric acid	Aspergillus terreus NIH2624
BGC0001289.5	0.35	ribosomal	penisin	Paenibacillus ehimensis
BGC0001647.3	0.34	PKS	lagunapyrone A, lagunapyrone B, lagunapyrone C	Streptomyces sp. MP131-18
BGC0001928.2	0.32	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0001964.2	0.32	PKS	alkylpyrone-407, alkylpyrone-393	Cystobacterineae bacterium
BGC0002254.3	0.31	PKS	notoamide F, (+)-semivioxanthin, waikikiamide B, waikikiamide C, notoamide A, waikikiamide A	Aspergillus sp. FM242
BGC0001663.3	0.30	PKS	merocyclophane C, merocyclophane D	Nostoc sp. UIC 10110

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000282.3	0.55	PKS	2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3	0.51	PKS	alkylpyrone-407, alkylpyrone-393	Myxococcus xanthus DK 1622
BGC0002332.2	0.44	PKS	4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A	Candidatus Entotheonella sp.
BGC0001475.4	0.43	terpene	aspterric acid	Aspergillus terreus NIH2624
BGC0001289.5	0.35	ribosomal	penisin	Paenibacillus ehimensis
BGC0001647.3	0.34	PKS	lagunapyrone A, lagunapyrone B, lagunapyrone C	Streptomyces sp. MP131-18
BGC0001928.2	0.32	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0001964.2	0.32	PKS	alkylpyrone-407, alkylpyrone-393	Cystobacterineae bacterium
BGC0002254.3	0.31	PKS	notoamide F, (+)-semivioxanthin, waikikiamide B, waikikiamide C, notoamide A, waikikiamide A	Aspergillus sp. FM242
BGC0001663.3	0.30	PKS	merocyclophane C, merocyclophane D	Nostoc sp. UIC 10110

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 27.26 out of 29.38

Confidence: strong

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.48 out of 23.79

Confidence: strong

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.67 out of 21.55

Confidence: medium

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.26 out of 21.55

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 25.16 out of 28.19

Confidence: strong

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.73 out of 28.19

Confidence: strong

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.47 out of 20.01

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.57 out of 25.31

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.38 out of 26.06

Confidence: medium

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.73 out of 29.25

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.84 out of 29.38

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.21 out of 30.25

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.89 out of 18.16

Confidence: strong

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.38 out of 24.78

Confidence: medium

Additional weak hits (6):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.23 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.58 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 26.01 out of 32.74

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.09 out of 30.25

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.03 out of 30.25

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.02 out of 29.65

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
ArcA	Repressor of carbon oxidation
ArgR	Regulator of arginine biosynthesis genes
CatR	H2O2-responsive repressor
ColR	Phenol-responsive regulator
FuR variant 1	Ferric Uptake Regulator
IolR	Regulator of the inositol catabolism
LexA variant 2	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
SypG	Regulator of biofilm formation and host colonization
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_CP032146.1 - Region 11 - terpene-precursor

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Location: 2,456,995 - 2,477,885 nt. (total: 20,891 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: carboxylase

D2M30_RS12385: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase

D2M30_RS12350: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

D2M30_RS12355: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000639.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0000638.3	0.37	terpene	carotenoid	Pantoea ananatis
BGC0000640.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC404

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000639.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0000638.3	0.37	terpene	carotenoid	Pantoea ananatis
BGC0000640.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC404

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

D2M30_RS12355: PT_FPPS_like

Domain 1 (33 - 296): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.14 out of 27.78

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.59 out of 30.25

Confidence: medium

Additional weak hits (1):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.48 out of 26.06

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator

NZ_CP032146.1 - Region 12 - NRP-metallophore,NRPS,terpene-precursor

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Location: 3,068,972 - 3,134,235 nt. (total: 65,264 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)
NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase reductase

D2M30_RS15750: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

D2M30_RS15825: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

D2M30_RS15875: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

D2M30_RS15885: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

D2M30_RS15900: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

D2M30_RS15925: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Hydrolases: esterase hydrolase

D2M30_RS15665: thioesterase superfamily protein

smcogs: SMCOG1144: thioesterase superfamily protein

D2M30_RS15715: isochorismatase

smcogs: SMCOG1027: isochorismatase

D2M30_RS15810: isochorismatase

smcogs: SMCOG1027: isochorismatase

Isomerases: isomerase

D2M30_RS15820: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: ligase synthetase

D2M30_RS15685: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

D2M30_RS15805: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

D2M30_RS15815: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001185.5	1.40	NRPS	bacillibactin	Bacillus velezensis FZB42
BGC0000309.5	1.05	NRPS	bacillibactin	Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5	1.04	NRPS	paenibactin	Paenibacillus elgii B69
BGC0002075.3	0.87	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0000343.5	0.86	NRPS	enterobactin	Pseudomonas sp. J465
BGC0001132.4	0.77	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.76	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.75	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.73	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.73	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001185.5	0.89	NRPS	bacillibactin	Bacillus velezensis FZB42
BGC0000309.5	0.80	NRPS	bacillibactin	Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5	0.80	NRPS	paenibactin	Paenibacillus elgii B69
BGC0002075.3	0.74	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0000343.5	0.74	NRPS	enterobactin	Pseudomonas sp. J465
BGC0001132.4	0.71	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.70	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001128.4	0.69	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.69	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

D2M30_RS15685: PT_FPPS_like

Domain 1 (43 - 297): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 29.38 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.61 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 27.15 out of 29.38

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.49 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.52 out of 27.78

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.49 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.91 out of 29.38

Confidence: medium

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 23.25 out of 29.72

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.52 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.97 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.08 out of 26.06

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.73 out of 28.19

Confidence: strong

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.18 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.81 out of 28.19

Confidence: medium

Additional weak hits (22):

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.98 out of 27.55

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.88 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.45 out of 26.06

Confidence: weak

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 22.13 out of 29.51

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.39 out of 31.73

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.44 out of 31.73

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.84 out of 29.25

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.61 out of 32.74

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.12 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.52 out of 32.74

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.31 out of 29.38

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.58 out of 26.06

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 21.95 out of 31.73

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.64 out of 31.73

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.85 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.41 out of 26.06

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.11 out of 33.14

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 21.63 out of 30.12

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.56 out of 33.14

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Terpene

TFBS Finder

Predicted core structure(s)

For candidate cluster 14, location 3068971 - 3134235:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 16, location 3082507 - 3134235:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed

NRPS/PKS substrate predictions

D2M30_RS15805: Gly - Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (456..855): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FSMTFDISGLELQALVGGETNLYGPTETTIWSAA
Nearest Stachelhaus code(s):: Gly DILQLGLIWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1513..1929): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LSTHFDFSVWEGNQIFGGEVNMYGITETTVHVSY
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

D2M30_RS15815: diOH-Bz

Search NORINE for peptide: strict or relaxed

AMP-binding (31..435): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: SLSLYPLSSPGGALQVGGAQQVFGMAEGLVNYTR
Nearest Stachelhaus code(s):: diOH-Bz PLPAQGVVNK (97% 8Å match); diOH-Bz or Sal PLPAQGVVNK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1	Ferric Uptake Regulator
MogR	Repressor of flagellar motility genes
NtrC	Nitrogen regulatory protein C
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_CP032146.1 - Region 13 - other