Select genomic region:
Overview
1.1
1.2
1.3
1.4
1.5
1.6
1.7
1.8
1.9
1.10
1.11
1.12
1.13

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP032146.1 (Bacillus amyloliquefaciens)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1 | NRPS | 306,034 | 371,444 | High | surfactin | NRPS:Type I
Region 2 | HR-T2PKS | 649,855 | 692,023 |
Region 3 | lanthipeptide-class-iii | 774,243 | 796,840 |
Region 4 | PKS-like | 915,929 | 957,173 |  |
Region 5 | terpene | 1,041,867 | 1,062,610 |
Region 6 | transAT-PKS | 1,384,092 | 1,472,296 | High | macrolactin H | PKS
Region 7 | transAT-PKS,T3PKS,NRPS | 1,690,216 | 1,800,340 | High | bacillaene | NRPS:Type I+PKS:Type I
Region 8 | NRPS,transAT-PKS,betalactone | 1,850,564 | 1,987,202 | High | fengycin | NRPS:Type I
Region 9 | terpene | 2,020,975 | 2,042,858 |
Region 10 | T3PKS | 2,097,950 | 2,139,050 |
Region 11 | terpene-precursor | 2,456,995 | 2,477,885 |
Region 12 | terpene-precursor,NRP-metallophore,NRPS | 3,068,972 | 3,134,235 | High | bacillibactin | NRPS:Type I
Region 13 | other | 3,642,979 | 3,684,397 | High | bacilysin | other:other

NZ_CP032146.1 - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 306,034 - 371,444 nt. (total: 65,411 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase reductase
D2M30_RS01700: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

D2M30_RS01715: alkyl hydroperoxide reductase subunit

smcogs
  SMCOG1176: alkyl hydroperoxide reductase subunit

D2M30_RS01730: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

D2M30_RS01745: alcohol dehydrogenase

smcogs
  SMCOG1040: alcohol dehydrogenase

D2M30_RS01900: oxidoreductase

smcogs
  SMCOG1083: oxidoreductase

Transferases: PPTase aminotransferase
D2M30_RS01815: aminotransferase

smcogs
  SMCOG1019: aminotransferase

D2M30_RS01820: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: esterase
D2M30_RS01810: thioesterase

smcogs
  SMCOG1004: thioesterase

Ligases: ligase synthase
D2M30_RS01740: cobalamin synthesis protein/P47K family protein

smcogs
  SMCOG1178: cobalamin synthesis protein/P47K family protein

D2M30_RS01795: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

D2M30_RS01805: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

D2M30_RS20800: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

D2M30_RS20810: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000433.5 |  | 0.80 | NRPS | surfactin | Bacillus velezensis FZB42
BGC0001833.4 |  | 0.75 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002135.2 |  | 0.74 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0002075.3 |  | 0.73 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0002286.3 |  | 0.73 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  | 0.73 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4 |  | 0.73 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001135.5 |  | 0.73 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001758.4 |  | 0.72 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001825.4 |  | 0.72 | NRPS | xenematide | Xenorhabdus nematophila AN6/1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000433.5 |  | 0.80 | NRPS | surfactin | Bacillus velezensis FZB42
BGC0001833.4 |  | 0.75 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002135.2 |  | 0.74 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0002075.3 |  | 0.73 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0002286.3 |  | 0.73 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  | 0.73 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4 |  | 0.73 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001135.5 |  | 0.73 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001758.4 |  | 0.72 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001825.4 |  | 0.72 | NRPS | xenematide | Xenorhabdus nematophila AN6/1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.55 out of 29.38
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.80 out of 27.78
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.02 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.50 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.76 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.41 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.42 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.88 out of 26.06
Confidence: medium
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 26.49 out of 35.63
Confidence: medium
Additional weak hits (20):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.89 out of 29.38
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.74 out of 32.74
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.52 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.40 out of 26.06
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 21.71 out of 33.73
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.87 out of 26.06
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.13 out of 30.97
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.49 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.26 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.21 out of 26.06
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 20.78 out of 29.38
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.38 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.99 out of 26.06
Confidence: weak
RicR
Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 22.36 out of 32.93
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 21.56 out of 31.73
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.35 out of 30.25
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.59 out of 31.73
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 21.63 out of 30.12
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 22.50 out of 35.63
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 21.97 out of 30.98
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 306033 - 371444:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Glu - Leu - D-Leu) + (Val) + (Asp - D-Leu) + (Ile)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
D2M30_RS01795: Glu - Leu - Leu
Search NORINE for peptide: strict or relaxed
AMP-binding (465..867): Glu
nrpys: Glu

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    gln (Gln)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LSLAFDASVKQADGLIGGETNVYGPTETCVDASV
  Nearest Stachelhaus code(s):
    Glu DAKDLGVVDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1511..1908): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TNTSFDAFMFDGMIMFGGELHMYGPSESTVFATY
  Nearest Stachelhaus code(s):
    Leu DAFMMGMVFK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (2550..2939): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LWHAFDASIWEPFLLVGGDVNNYGPTENTVVATS
  Nearest Stachelhaus code(s):
    Leu DAWFLGNVVK (97% 8Å match)
  Stachelhaus code match:
    100% (strong)

D2M30_RS20800: Val
Search NORINE for peptide: strict or relaxed
AMP-binding (470..864): Val
nrpys: Val

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    val (Val)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LHSGFDAGTFEGWLIIGGDWNGYGPTENTTFSTS
  Nearest Stachelhaus code(s):
    Val DAFWIGGTFK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

D2M30_RS20810: Asp - Leu
Search NORINE for peptide: strict or relaxed
AMP-binding (429..831): Asp
nrpys: Asp

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asp (Asp)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWFSFDLGYTAPKLVLGGEINHYGPTETTIGAIA
  Nearest Stachelhaus code(s):
    Asp DLTKVGHIGK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1474..1863): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LWHAFDAAIWEPFLLVGGDVNNYGPTENTVVATS
  Nearest Stachelhaus code(s):
    Leu DAWFLGNVVK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

D2M30_RS01805: Ile
Search NORINE for peptide: strict or relaxed
AMP-binding (469..867): Ile
nrpys: Ile

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    ile (Ile)

Stachelhaus prediction details:
  Stachelhaus sequence:
    IHTSFDGFTFDAFVLFGGEIHVYGPTEVTVFATA
  Nearest Stachelhaus code(s):
    Ile DGFFLGVVFK (85% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1 | Ferric Uptake Regulator
MogR | Repressor of flagellar motility genes
NrtR | NAD synthesis repressor
ToxT | Regulator of MSHA biosynthesis

NZ_CP032146.1 - Region 2 - HR-T2PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 649,855 - 692,023 nt. (total: 42,169 nt) Show pHMM detection rules used
HR-T2PKS: (hr-t2pks-ksa and (t2fas or APE_KS2 or ketoacyl-synt))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
D2M30_RS03455: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Hydrolases: amidase
D2M30_RS03395: amidase

smcogs
  SMCOG1105: amidase

Ligases: synthase
D2M30_RS03445: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | HR-T2PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000866.5 |  | 0.50 | other (other) | polyhydroxyalkanoate | Burkholderia sp. DSM 9242
BGC0000888.5 |  | 0.48 | other (other) | bacilysin | Bacillus sp. CS93
BGC0001184.4 |  | 0.46 | other (other) | bacilysin | Bacillus velezensis FZB42
BGC0000231.5 |  | 0.46 | PKS | griseusin A, griseusin B | Streptomyces griseus
BGC0002404.2 |  | 0.46 | other (other) | falcarindiol | Solanum lycopersicum
BGC0001987.2 |  | 0.46 | PKS | koreenceine A, koreenceine B, koreenceine C, koreenceine D | Pseudomonas koreensis
BGC0001197.5 |  | 0.45 | PKS | frankiamicin | Frankia sp. EAN1pec
BGC0000948.5 |  | 0.45 | other (other) | α-galactosylceramide | Bacteroides fragilis NCTC 9343
BGC0000204.5 |  | 0.44 | PKS | benastatin A, benastatin B, BE-43767, TAN1532B | Streptomyces sp. A2991200
BGC0000234.5 |  | 0.44 | PKS | jadomycin | Streptomyces venezuelae ATCC 10712

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000866.5 |  | 0.50 | other (other) | polyhydroxyalkanoate | Burkholderia sp. DSM 9242
BGC0000888.5 |  | 0.48 | other (other) | bacilysin | Bacillus sp. CS93
BGC0001184.4 |  | 0.46 | other (other) | bacilysin | Bacillus velezensis FZB42
BGC0000231.5 |  | 0.46 | PKS | griseusin A, griseusin B | Streptomyces griseus
BGC0002404.2 |  | 0.46 | other (other) | falcarindiol | Solanum lycopersicum
BGC0001987.2 |  | 0.46 | PKS | koreenceine A, koreenceine B, koreenceine C, koreenceine D | Pseudomonas koreensis
BGC0001197.5 |  | 0.45 | PKS | frankiamicin | Frankia sp. EAN1pec
BGC0000948.5 |  | 0.45 | other (other) | α-galactosylceramide | Bacteroides fragilis NCTC 9343
BGC0000204.5 |  | 0.44 | PKS | benastatin A, benastatin B, BE-43767, TAN1532B | Streptomyces sp. A2991200
BGC0000234.5 |  | 0.44 | PKS | jadomycin | Streptomyces venezuelae ATCC 10712

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.58 out of 21.84
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.63 out of 27.78
Confidence: medium
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.57 out of 26.33
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16
Confidence: strong
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.63 out of 26.85
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.72 out of 29.38
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 25.16 out of 28.19
Confidence: strong
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.73 out of 28.19
Confidence: medium
Additional weak hits (8):
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.98 out of 27.55
Confidence: weak
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.06 out of 26.33
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.41 out of 30.11
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 23.52 out of 33.73
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.81 out of 31.73
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.43 out of 29.38
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.26 out of 32.74
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.19 out of 32.93
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
AbrC3 | Antibiotic production activator
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1 | Ferric Uptake Regulator
MexT | Global virulence regulator
RutR | Regulator of the pyrimidine and purine metabolism
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_CP032146.1 - Region 3 - lanthipeptide-class-iii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 774,243 - 796,840 nt. (total: 22,598 nt) Show pHMM detection rules used
lanthipeptide-class-iii: (micKC and not PKS_KS)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
D2M30_RS04035: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Hydrolases: protease
D2M30_RS03990: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Ligases: synthase
D2M30_RS04025: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-iii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001535.3 |  | 0.76 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0002700.2 |  | 0.54 | ribosomal | bacinapeptin | Bacillus nakamurai
BGC0002111.3 |  | 0.51 | ribosomal | andalusicin A, andalusicin B | Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0001226.4 |  | 0.49 | ribosomal | streptocollin | Streptomyces collinus Tu 365
BGC0000563.4 |  | 0.49 | ribosomal | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0000551.5 |  | 0.48 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000501.3 |  | 0.48 | ribosomal | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0000519.4 |  | 0.48 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000504.5 |  | 0.47 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000496.5 |  | 0.46 | ribosomal | AmfS | Streptomyces griseus subsp. griseus NBRC 13350

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001535.3 |  | 0.76 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0002700.2 |  | 0.54 | ribosomal | bacinapeptin | Bacillus nakamurai
BGC0002111.3 |  | 0.51 | ribosomal | andalusicin A, andalusicin B | Bacillus thuringiensis serovar andalousiensis NRRL B-23139
BGC0001226.4 |  | 0.49 | ribosomal | streptocollin | Streptomyces collinus Tu 365
BGC0000563.4 |  | 0.49 | ribosomal | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0000551.5 |  | 0.48 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0000501.3 |  | 0.48 | ribosomal | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0000519.4 |  | 0.48 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000504.5 |  | 0.47 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000496.5 |  | 0.46 | ribosomal | AmfS | Streptomyces griseus subsp. griseus NBRC 13350

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for D2M30_RS04000

D2M30_RS20755
Leader:
MKDVLELQQLNEGTEVEASKGKGG
Core:
L L T L I T T I V G S S T I S N N C
Core with dehydrations:
L L Dhb L I Dhb Dhb I V G Dha Dha Dhb I Dha N N Cys

#### antiSMASH-DB 4.0 matches for D2M30_RS20755

100.0%
NC_014551.1 and 5 others:
NC_017188.1 Lanthipeptides: BAMTA208_RS20930_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20755_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03870_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20395_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19840_lanthipeptide
Lanthipeptides: BAMF_RS41655_lanthipeptide
1
L L T L I T T I V G S S T I S N N C
18
L L T L I T T I V G S S T I S N N C
1
L L T L I T T I V G S S T I S N N C
18
94.4%
NZ_CP026010.1 and 18 others:
NZ_CP026010.1 Lanthipeptides: BS11774_RS22085_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21825_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21845_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04850_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04870_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19020_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19000_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21910_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21930_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21925_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21920_lanthipeptide NZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19790_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18865_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18885_lanthipeptide NZ_JALAVZ010000001.1 Lanthipeptides: MOF00_RS00410_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19490_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19510_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19505_lanthipeptide
Lanthipeptides: BS11774_RS22075_lanthipeptide
1
L L T L I T T I V G S S T I S N N C
18
L L T L I T T I V G+S T I S N N C
1
L L T L I T T I V G T S T I S N N C
18
88.9%
NC_014551.1 and 27 others:
NC_014551.1 Lanthipeptides: BAMF_RS41675_lanthipeptide NC_014551.1 Lanthipeptides: BAMF_RS41665_lanthipeptide NC_017188.1 Lanthipeptides: BAMTA208_RS20945_lanthipeptide NC_017188.1 Lanthipeptides: BAMTA208_RS20950_lanthipeptide NC_017188.1 Lanthipeptides: BAMTA208_RS20940_lanthipeptide NZ_CP026010.1 Lanthipeptides: BS11774_RS22090_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20770_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20775_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20765_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21840_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21835_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04865_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04860_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03885_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03890_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03880_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19010_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19005_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20380_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20385_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18880_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18875_lanthipeptide NZ_JALAUK010000033.1 Lanthipeptides: MOE38_RS18580_lanthipeptide NZ_JALAVZ010000001.1 Lanthipeptides: MOF00_RS00405_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19500_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19860_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19855_lanthipeptide
Lanthipeptides: BAMF_RS41670_lanthipeptide
1
L L T L I T T I V G S S T I S N N C
18
L L T L I T T+V G+S T I S N N C
1
L L T L I T T V V G T S T I S N N C
18
with 12 more sequence matches
Only the first 10 are displayed here.
50.0%
NC_014551.1 and 13 others:
NC_017188.1 Lanthipeptides: BAMTA208_RS20935_lanthipeptide NZ_CP026010.1 Lanthipeptides: BS11774_RS22080_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20760_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21830_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04855_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03875_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19015_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20390_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21915_lanthipeptide NZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19785_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18870_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19495_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19845_lanthipeptide
Lanthipeptides: BAMF_RS41660_lanthipeptide
2
L T L I T T I V G S S T I S N N C
18
T L+T T++G+S T I S N+C
4
W T L L T T L I G T S T I S N S C
20
50.0%
NZ_LN868937.1 and 1 other:
NZ_LN868937.1 Lanthipeptides: BN2144_RS20095_lanthipeptide
Lanthipeptides: BN2144_RS20100_lanthipeptide
1
L L T L I T T I V G S S T I S N N C
18
T+ T T++G+S T I S N N C
4
W Y T I F T T L I G T S T I S N N C
21
45.0%
NZ_JAFFJY010000011.1:
Lanthipeptides: JVX89_RS12320_lanthipeptide
7
T I V G S S T I S N N C
18
T V G S T I S N C
9
T T V G L S T I S N G C
20
40.9%
NZ_LN868937.1:
Lanthipeptides: BN2144_RS19915_lanthipeptide
1
L L T L I T T I V G S S T I S N N C
18
T +T +V +S T I S N+C
5
W F T S V T L L V T T S T I S N H C
22
36.4%
NZ_CP066711.1:
Lanthipeptides: JGZ56_RS07825_lanthipeptide
2
L T L I T T I V G S S T I S N N C
18
L+ + + +G S T I S N+C
6
L S T L L S F L G G S T I S N H C
22
34.8%
NZ_CP035727.2 and 5 others:
NZ_CP035727.2 Lanthipeptides: EVG22_RS16230_lanthipeptide NZ_CP035727.2 Lanthipeptides: EVG22_RS16225_lanthipeptide NZ_CP035727.2 Lanthipeptides: EVG22_RS16220_lanthipeptide NZ_CP035727.2 Lanthipeptides: EVG22_RS16215_lanthipeptide NZ_CP035727.2 Lanthipeptides: EVG22_RS16210_lanthipeptide
Lanthipeptides: EVG22_RS16235_lanthipeptide
9
V G S S T I S N N C
18
V +S T I S N N C
14
V W A S T I S N N C
23
33.3%
NZ_BMVC01000018.1 and 6 others:
NZ_BMVC01000018.1 Lanthipeptides: IE282_RS34445_lanthipeptide NZ_BMVC01000018.1 Lanthipeptides: IE282_RS34455_lanthipeptide NZ_FOHE01000012.1 Lanthipeptides: BMX40_RS20340_lanthipeptide NZ_JALMDK010000006.1 Lanthipeptides: MZC64_RS26320_lanthipeptide NZ_JANBBG010000004.1 Lanthipeptides: allorf_1567890_1567982_lanthipeptide NZ_JANBBG010000004.1 Lanthipeptides: allorf_1567737_1567829_lanthipeptide
Lanthipeptides: IE282_RS34450_lanthipeptide
12
S T I S N N C
18
S T+S N N C
3
S T V S N N C
9
30.8%
NZ_CP003923.1 and 4 others:
NZ_CP042163.1 Lanthipeptides: FPV17_RS21685_lanthipeptide NZ_CP117834.1 Lanthipeptides: PQ477_RS10640_lanthipeptide NZ_KV917380.1 Lanthipeptides: BK583_RS20905_lanthipeptide NZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20340_lanthipeptide
Lanthipeptides: BLEG1_RS21170_lanthipeptide
2
L T L I T T I V G S S T I S N N C
18
+T T++G S T S N+C
10
I T T T R T V I G W S T A S N S C
26
30.4%
NZ_CP014806.1 and 3 others:
NZ_CP014806.1 Lanthipeptides: ATY39_RS17975_lanthipeptide NZ_CP014806.1 Lanthipeptides: ATY39_RS17970_lanthipeptide NZ_CP014806.1 Lanthipeptides: ATY39_RS17965_lanthipeptide
Lanthipeptides: ATY39_RS17980_lanthipeptide
9
V G S S T I S N N C
18
V +S T I S N+C
14
V F A S T I S N H C
23
30.4%
NZ_CP035727.2:
Lanthipeptides: EVG22_RS16240_lanthipeptide
11
S S T I S N N C
18
+S T I S N N C
16
A S T I S N N C
23

#### MIBiG 4.0 matches for D2M30_RS20755

34.8%
BGC0002111.3 (multiple genes):
Lanthipeptide: andalusicin A or andalusicin B
9
V G S S T I S N N C
18
V +S T I S N N C
14
V W A S T I S N N C
23
30.4%
BGC0002111.3 (EVG22_32245):
Lanthipeptide: andalusicin A or andalusicin B
11
S S T I S N N C
18
+S T I S N N C
16
A S T I S N N C
23
D2M30_RS20760
Leader:
MNEVLELQQLSKGSEVE
Core:
T A G W T L L T T L I G T S T I S N S C N K
Core with dehydrations:
Dhb A G W Dhb L L Dhb Dhb L I G Dhb Dha Dhb I Dha N Dha Cys N K

#### antiSMASH-DB 4.0 matches for D2M30_RS20760

100.0%
NC_014551.1 and 13 others:
NC_017188.1 Lanthipeptides: BAMTA208_RS20935_lanthipeptide NZ_CP026010.1 Lanthipeptides: BS11774_RS22080_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20760_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21830_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04855_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03875_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19015_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20390_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21915_lanthipeptide NZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19785_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18870_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19495_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19845_lanthipeptide
Lanthipeptides: BAMF_RS41660_lanthipeptide
1
T A G W T L L T T L I G T S T I S N S C N K
22
T A G W T L L T T L I G T S T I S N S C N K
1
T A G W T L L T T L I G T S T I S N S C N K
22
63.6%
NZ_LN868937.1:
Lanthipeptides: BN2144_RS19915_lanthipeptide
1
T A G W--T L L T T L I G T S T I S N S C
20
T A G W T +T L+ T S T I S N C
1
T A G W W F T S V T L L V T T S T I S N H C
22
60.9%
NZ_LN868937.1:
Lanthipeptides: BN2144_RS20095_lanthipeptide
4
W T L L T T L I G T S T I S N S C N K
22
+T+ T T L I G T S T I S N+C K
5
Y T I F T T L I G T S T I S N N C G K
23
with 10 more sequence matches
59.1%
NZ_LN868937.1:
Lanthipeptides: BN2144_RS20100_lanthipeptide
4
W T L L T T L I G T S T I S N S C
20
+T+ T T L I G T S T I S N+C
5
Y T I F T T L I G T S T I S N N C
21
54.5%
NC_014551.1 and 27 others:
NC_014551.1 Lanthipeptides: BAMF_RS41665_lanthipeptide NC_014551.1 Lanthipeptides: BAMF_RS41670_lanthipeptide NC_017188.1 Lanthipeptides: BAMTA208_RS20950_lanthipeptide NC_017188.1 Lanthipeptides: BAMTA208_RS20940_lanthipeptide NC_017188.1 Lanthipeptides: BAMTA208_RS20945_lanthipeptide NZ_CP026010.1 Lanthipeptides: BS11774_RS22090_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20775_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20765_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20770_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21840_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21835_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04865_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04860_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03890_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03880_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03885_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19010_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19005_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20385_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20380_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18880_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18875_lanthipeptide NZ_JALAUK010000033.1 Lanthipeptides: MOE38_RS18580_lanthipeptide NZ_JALAVZ010000001.1 Lanthipeptides: MOF00_RS00405_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19500_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19860_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19855_lanthipeptide
Lanthipeptides: BAMF_RS41675_lanthipeptide
4
W T L L T T L I G T S T I S N S C
20
T L+T T++G T S T I S N+C
2
L T L I T T V V G T S T I S N N C
18
54.5%
NZ_CP026010.1 and 18 others:
NZ_CP026010.1 Lanthipeptides: BS11774_RS22085_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21825_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21845_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04850_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04870_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19020_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19000_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21910_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21930_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21925_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21920_lanthipeptide NZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19790_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18865_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18885_lanthipeptide NZ_JALAVZ010000001.1 Lanthipeptides: MOF00_RS00410_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19490_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19510_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19505_lanthipeptide
Lanthipeptides: BS11774_RS22075_lanthipeptide
4
W T L L T T L I G T S T I S N S C
20
T L+T T++G T S T I S N+C
2
L T L I T T I V G T S T I S N N C
18
50.0%
NC_014551.1 and 5 others:
NC_017188.1 Lanthipeptides: BAMTA208_RS20930_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20755_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03870_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20395_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19840_lanthipeptide
Lanthipeptides: BAMF_RS41655_lanthipeptide
4
W T L L T T L I G T S T I S N S C
20
T L+T T++G+S T I S N+C
2
L T L I T T I V G S S T I S N N C
18
50.0%
NZ_JAFFJY010000011.1:
Lanthipeptides: JVX89_RS12320_lanthipeptide
3
G W T L L T-T L I G T S T I S N S C
20
G+T T T +G S T I S N C
2
G Y T P T T V T T V G L S T I S N G C
20
40.9%
NZ_CP066711.1:
Lanthipeptides: JGZ56_RS07825_lanthipeptide
3
G W T L L T T L I G T S T I S N S C
20
G + L + +G S T I S N C
5
G L S T L L S F L G G S T I S N H C
22
40.9%
NZ_FOHE01000012.1 and 1 other:
NZ_FOHE01000012.1 Lanthipeptides: BMX40_RS20540_lanthipeptide
Lanthipeptides: BMX40_RS20545_lanthipeptide
3
G W T L L T T L I G T S T I S N S C
20
G W T T+ S T+S N C
2
G W T W T V T I F-L S T V S N H C
18
34.6%
NZ_CP003923.1 and 4 others:
NZ_CP042163.1 Lanthipeptides: FPV17_RS21685_lanthipeptide NZ_CP117834.1 Lanthipeptides: PQ477_RS10640_lanthipeptide NZ_KV917380.1 Lanthipeptides: BK583_RS20905_lanthipeptide NZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20340_lanthipeptide
Lanthipeptides: BLEG1_RS21170_lanthipeptide
9
T L I G T S T I S N S C
20
T+I G S T S N S C
15
T V I G W S T A S N S C
26
33.3%
NZ_CP066711.1:
Lanthipeptides: allorf_1652598_1652744_lanthipeptide
9
T L I G T S T I S N S C N K
22
T+ G S T I S N C N K
14
T V Y G L S T I S N K C N K
27
17.2%
NZ_FOHE01000012.1:
Lanthipeptides: BMX40_RS20340_lanthipeptide
14
S T I S N S C N K
22
S T+S N+C++
19
S T V S N N C D R
27

#### MIBiG 4.0 matches for D2M30_RS20760

31.8%
BGC0000563.4 (AEA03263.1):
Lanthipeptide: venezuelin
7
L T T L I G T S T I S N S C
20
L T L+ T I S C
8
L L T L L N T V C I G I S C
21
26.1%
BGC0002111.3 (EVG22_32245):
Lanthipeptide: andalusicin A or andalusicin B
13
T S T I S N S C
20
S T I S N+C
16
A S T I S N N C
23
26.1%
BGC0002111.3 (multiple genes):
Lanthipeptide: andalusicin A or andalusicin B
14
S T I S N S C
20
S T I S N+C
17
S T I S N N C
23
D2M30_RS20765
Leader:
MRDVLELQQLNEGTEVEASKGKGG
D2M30_RS20775
Leader:
MKDVLELQQLNEGTEVEASKGKGG
Shared core:
L L T L I T T V V G T S T I S N N C G
Core with dehydrations:
L L Dhb L I Dhb Dhb V V G Dhb Dha Dhb I Dha N N Cys G

#### antiSMASH-DB 4.0 matches for D2M30_RS20765

100.0%
NC_014551.1 and 21 others:
NC_014551.1 Lanthipeptides: BAMF_RS41665_lanthipeptide NC_017188.1 Lanthipeptides: BAMTA208_RS20950_lanthipeptide NC_017188.1 Lanthipeptides: BAMTA208_RS20940_lanthipeptide NZ_CP026010.1 Lanthipeptides: BS11774_RS22090_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20775_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20765_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21840_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21835_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04865_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04860_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03890_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03880_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19010_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19005_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20385_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18880_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18875_lanthipeptide NZ_JALAVZ010000001.1 Lanthipeptides: MOF00_RS00405_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19500_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19860_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19855_lanthipeptide
Lanthipeptides: BAMF_RS41675_lanthipeptide
1
L L T L I T T V V G T S T I S N N C G
19
L L T L I T T V V G T S T I S N N C G
1
L L T L I T T V V G T S T I S N N C G
19
94.7%
NC_014551.1 and 5 others:
NC_017188.1 Lanthipeptides: BAMTA208_RS20945_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20770_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03885_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20380_lanthipeptide NZ_JALAUK010000033.1 Lanthipeptides: MOE38_RS18580_lanthipeptide
Lanthipeptides: BAMF_RS41670_lanthipeptide
1
L L T L I T T V V G T S T I S N N C
18
L L T L I T T V V G T S T I S N N C
1
L L T L I T T V V G T S T I S N N C
18
94.7%
NZ_CP026010.1 and 9 others:
NZ_CP054584.1 Lanthipeptides: HT135_RS21845_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04870_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19000_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21930_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21925_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21920_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18885_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19510_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19505_lanthipeptide
Lanthipeptides: BS11774_RS22085_lanthipeptide
1
L L T L I T T V V G T S T I S N N C G
19
L L T L I T T+V G T S T I S N N C G
1
L L T L I T T I V G T S T I S N N C G
19
with 22 more sequence matches
Only the first 10 are displayed here.
89.5%
NZ_CP026010.1 and 8 others:
NZ_CP054584.1 Lanthipeptides: HT135_RS21825_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04850_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19020_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21910_lanthipeptide NZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19790_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18865_lanthipeptide NZ_JALAVZ010000001.1 Lanthipeptides: MOF00_RS00410_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19490_lanthipeptide
Lanthipeptides: BS11774_RS22075_lanthipeptide
1
L L T L I T T V V G T S T I S N N C
18
L L T L I T T+V G T S T I S N N C
1
L L T L I T T I V G T S T I S N N C
18
84.2%
NC_014551.1 and 5 others:
NC_017188.1 Lanthipeptides: BAMTA208_RS20930_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20755_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03870_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20395_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19840_lanthipeptide
Lanthipeptides: BAMF_RS41655_lanthipeptide
1
L L T L I T T V V G T S T I S N N C
18
L L T L I T T+V G+S T I S N N C
1
L L T L I T T I V G S S T I S N N C
18
56.5%
NZ_LN868937.1:
Lanthipeptides: BN2144_RS20095_lanthipeptide
1
L L T L I T T V V G T S T I S N N C G
19
T+ T T++G T S T I S N N C G
4
W Y T I F T T L I G T S T I S N N C G
22
54.5%
NC_014551.1 and 13 others:
NC_017188.1 Lanthipeptides: BAMTA208_RS20935_lanthipeptide NZ_CP026010.1 Lanthipeptides: BS11774_RS22080_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20760_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21830_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04855_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03875_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19015_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20390_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21915_lanthipeptide NZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19785_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18870_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19495_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19845_lanthipeptide
Lanthipeptides: BAMF_RS41660_lanthipeptide
2
L T L I T T V V G T S T I S N N C
18
T L+T T++G T S T I S N+C
4
W T L L T T L I G T S T I S N S C
20
54.5%
NZ_LN868937.1:
Lanthipeptides: BN2144_RS20100_lanthipeptide
1
L L T L I T T V V G T S T I S N N C
18
T+ T T++G T S T I S N N C
4
W Y T I F T T L I G T S T I S N N C
21
45.5%
NZ_LN868937.1:
Lanthipeptides: BN2144_RS19915_lanthipeptide
1
L L T L I T T V V G T S T I S N N C
18
T +T +V T S T I S N+C
5
W F T S V T L L V T T S T I S N H C
22
45.0%
NZ_JAFFJY010000011.1:
Lanthipeptides: JVX89_RS12320_lanthipeptide
7
T V V G T S T I S N N C
18
T V G S T I S N C
9
T T V G L S T I S N G C
20
36.8%
NC_016109.1 and 5 others:
NC_016109.1 Lanthipeptides: KSE_RS43700_lanthipeptide NZ_CP068437.1 Lanthipeptides: JK628_RS03400_lanthipeptide NZ_CP068437.1 Lanthipeptides: JK628_RS03395_lanthipeptide NZ_CP068437.1 Lanthipeptides: allorf_0778008_0778106_lanthipeptide NZ_CP068437.1 Lanthipeptides: JK628_RS03405_lanthipeptide
Lanthipeptides: KSE_RS43695_lanthipeptide
12
S T I S N N C G
19
S T I S N+C G
2
S T I S N H C G
9
36.8%
NC_016109.1:
Lanthipeptides: KSE_RS43705_lanthipeptide
12
S T I S N N C G
19
S T I S N C G
2
S T I S N Y C G
9
36.8%
NZ_BMVC01000018.1 and 1 other:
NZ_BMVC01000018.1 Lanthipeptides: IE282_RS34445_lanthipeptide
Lanthipeptides: IE282_RS34450_lanthipeptide
12
S T I S N N C G
19
S T+S N N C G
3
S T V S N N C G
10

#### MIBiG 4.0 matches for D2M30_RS20765

34.8%
BGC0002111.3 (multiple genes):
Lanthipeptide: andalusicin A or andalusicin B
9
V G T S T I S N N C
18
V S T I S N N C
14
V W A S T I S N N C
23
30.4%
BGC0002111.3 (EVG22_32245):
Lanthipeptide: andalusicin A or andalusicin B
11
T S T I S N N C
18
S T I S N N C
16
A S T I S N N C
23
D2M30_RS20770
Leader:
MRDVLELQQLNEGTEVEASKGKGG
Core:
L L T L I T T V V G T S T I S N N C
Core with dehydrations:
L L Dhb L I Dhb Dhb V V G Dhb Dha Dhb I Dha N N Cys

#### antiSMASH-DB 4.0 matches for D2M30_RS20770

100.0%
NC_014551.1 and 27 others:
NC_014551.1 Lanthipeptides: BAMF_RS41675_lanthipeptide NC_014551.1 Lanthipeptides: BAMF_RS41665_lanthipeptide NC_017188.1 Lanthipeptides: BAMTA208_RS20945_lanthipeptide NC_017188.1 Lanthipeptides: BAMTA208_RS20950_lanthipeptide NC_017188.1 Lanthipeptides: BAMTA208_RS20940_lanthipeptide NZ_CP026010.1 Lanthipeptides: BS11774_RS22090_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20770_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20775_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20765_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21840_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21835_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04865_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04860_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03885_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03890_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03880_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19010_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19005_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20380_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20385_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18880_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18875_lanthipeptide NZ_JALAUK010000033.1 Lanthipeptides: MOE38_RS18580_lanthipeptide NZ_JALAVZ010000001.1 Lanthipeptides: MOF00_RS00405_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19500_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19860_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19855_lanthipeptide
Lanthipeptides: BAMF_RS41670_lanthipeptide
1
L L T L I T T V V G T S T I S N N C
18
L L T L I T T V V G T S T I S N N C
1
L L T L I T T V V G T S T I S N N C
18
89.5%
NZ_CP026010.1 and 18 others:
NZ_CP026010.1 Lanthipeptides: BS11774_RS22075_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21845_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21825_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04870_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04850_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19000_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19020_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21930_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21925_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21920_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21910_lanthipeptide NZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19790_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18885_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18865_lanthipeptide NZ_JALAVZ010000001.1 Lanthipeptides: MOF00_RS00410_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19510_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19505_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19490_lanthipeptide
Lanthipeptides: BS11774_RS22085_lanthipeptide
1
L L T L I T T V V G T S T I S N N C
18
L L T L I T T+V G T S T I S N N C
1
L L T L I T T I V G T S T I S N N C
18
88.9%
NC_014551.1 and 5 others:
NC_017188.1 Lanthipeptides: BAMTA208_RS20930_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20755_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03870_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20395_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19840_lanthipeptide
Lanthipeptides: BAMF_RS41655_lanthipeptide
1
L L T L I T T V V G T S T I S N N C
18
L L T L I T T+V G+S T I S N N C
1
L L T L I T T I V G S S T I S N N C
18
with 13 more sequence matches
Only the first 10 are displayed here.
54.5%
NC_014551.1 and 13 others:
NC_017188.1 Lanthipeptides: BAMTA208_RS20935_lanthipeptide NZ_CP026010.1 Lanthipeptides: BS11774_RS22080_lanthipeptide NZ_CP032146.1 Lanthipeptides: D2M30_RS20760_lanthipeptide NZ_CP054584.1 Lanthipeptides: HT135_RS21830_lanthipeptide NZ_CP061284.1 Lanthipeptides: ICJ61_RS04855_lanthipeptide NZ_CP062984.1 Lanthipeptides: IL989_RS03875_lanthipeptide NZ_CP065858.1 Lanthipeptides: I7X10_RS19015_lanthipeptide NZ_DF836084.1 Lanthipeptides: CMW1_RS20390_lanthipeptide NZ_JAHVOC010000011.1 Lanthipeptides: KXD37_RS21915_lanthipeptide NZ_JALAPV010000012.1 Lanthipeptides: MOC91_RS19785_lanthipeptide NZ_JALAQA010000009.1 Lanthipeptides: MOD07_RS18870_lanthipeptide NZ_JANDGG010000010.1 Lanthipeptides: NKU38_RS19495_lanthipeptide NZ_KQ236689.1 Lanthipeptides: AD710_RS19845_lanthipeptide
Lanthipeptides: BAMF_RS41660_lanthipeptide
2
L T L I T T V V G T S T I S N N C
18
T L+T T++G T S T I S N+C
4
W T L L T T L I G T S T I S N S C
20
52.2%
NZ_LN868937.1 and 1 other:
NZ_LN868937.1 Lanthipeptides: BN2144_RS20100_lanthipeptide
Lanthipeptides: BN2144_RS20095_lanthipeptide
1
L L T L I T T V V G T S T I S N N C
18
T+ T T++G T S T I S N N C
4
W Y T I F T T L I G T S T I S N N C
21
45.5%
NZ_LN868937.1:
Lanthipeptides: BN2144_RS19915_lanthipeptide
1
L L T L I T T V V G T S T I S N N C
18
T +T +V T S T I S N+C
5
W F T S V T L L V T T S T I S N H C
22
45.0%
NZ_JAFFJY010000011.1:
Lanthipeptides: JVX89_RS12320_lanthipeptide
7
T V V G T S T I S N N C
18
T V G S T I S N C
9
T T V G L S T I S N G C
20
36.4%
NZ_CP066711.1:
Lanthipeptides: JGZ56_RS07825_lanthipeptide
2
L T L I T T V V G T S T I S N N C
18
L+ + + +G S T I S N+C
6
L S T L L S F L G G S T I S N H C
22
34.8%
NZ_CP035727.2 and 5 others:
NZ_CP035727.2 Lanthipeptides: EVG22_RS16230_lanthipeptide NZ_CP035727.2 Lanthipeptides: EVG22_RS16225_lanthipeptide NZ_CP035727.2 Lanthipeptides: EVG22_RS16220_lanthipeptide NZ_CP035727.2 Lanthipeptides: EVG22_RS16215_lanthipeptide NZ_CP035727.2 Lanthipeptides: EVG22_RS16210_lanthipeptide
Lanthipeptides: EVG22_RS16235_lanthipeptide
9
V G T S T I S N N C
18
V S T I S N N C
14
V W A S T I S N N C
23
34.6%
NZ_CP003923.1 and 4 others:
NZ_CP042163.1 Lanthipeptides: FPV17_RS21685_lanthipeptide NZ_CP117834.1 Lanthipeptides: PQ477_RS10640_lanthipeptide NZ_KV917380.1 Lanthipeptides: BK583_RS20905_lanthipeptide NZ_SNUX01000002.1 Lanthipeptides: E2L03_RS20340_lanthipeptide
Lanthipeptides: BLEG1_RS21170_lanthipeptide
2
L T L I T T V V G T S T I S N N C
18
+T T V+G S T S N+C
10
I T T T R T V I G W S T A S N S C
26
33.3%
NZ_BMVC01000018.1 and 6 others:
NZ_BMVC01000018.1 Lanthipeptides: IE282_RS34445_lanthipeptide NZ_BMVC01000018.1 Lanthipeptides: IE282_RS34455_lanthipeptide NZ_FOHE01000012.1 Lanthipeptides: BMX40_RS20340_lanthipeptide NZ_JALMDK010000006.1 Lanthipeptides: MZC64_RS26320_lanthipeptide NZ_JANBBG010000004.1 Lanthipeptides: allorf_1567890_1567982_lanthipeptide NZ_JANBBG010000004.1 Lanthipeptides: allorf_1567737_1567829_lanthipeptide
Lanthipeptides: IE282_RS34450_lanthipeptide
12
S T I S N N C
18
S T+S N N C
3
S T V S N N C
9
33.3%
NZ_CP068437.1 and 1 other:
NZ_CP068437.1 Lanthipeptides: JK628_RS03395_lanthipeptide
Lanthipeptides: JK628_RS03400_lanthipeptide
12
S T I S N N C
18
S T I S N+C
5
S T I S N H C
11
31.6%
NZ_CP014222.1:
Lanthipeptides: VN23_RS10390_lanthipeptide
7
T V V G T S T I S N N C
18
V S T+S N+C
2
Q V A D W S T V S N H C
13

#### MIBiG 4.0 matches for D2M30_RS20770

34.8%
BGC0002111.3 (multiple genes):
Lanthipeptide: andalusicin A or andalusicin B
9
V G T S T I S N N C
18
V S T I S N N C
14
V W A S T I S N N C
23
30.4%
BGC0002111.3 (EVG22_32245):
Lanthipeptide: andalusicin A or andalusicin B
11
T S T I S N N C
18
S T I S N N C
16
A S T I S N N C
23

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 18.25 out of 18.46
Confidence: strong
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.33 out of 30.25
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.90 out of 28.19
Confidence: medium
Additional weak hits (2):
BldD
Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.23 out of 23.43
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.73 out of 29.38
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

D2M30_RS20755 - Class III
  Cleavage pHMM score: 0.00
  RODEO score: 0
  Monoisotopic mass: 1723.0 Da
  Molecular weight: 1724.0 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1742.0 Da N = 1
    1760.0 Da N = 2
    1778.1 Da N = 3
    1796.1 Da N = 4
    1814.1 Da N = 5
    1832.1 Da N = 6
D2M30_RS20760 - Class III
  Cleavage pHMM score: -1.30
  RODEO score: 0
  Monoisotopic mass: 2119.2 Da
  Molecular weight: 2120.4 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2138.4 Da N = 1
    2156.4 Da N = 2
    2174.4 Da N = 3
    2192.5 Da N = 4
    2210.5 Da N = 5
    2228.5 Da N = 6
    2246.5 Da N = 7
    2264.5 Da N = 8
D2M30_RS20765 - Class III
  Cleavage pHMM score: 0.00
  RODEO score: 0
  Monoisotopic mass: 1780.0 Da
  Molecular weight: 1781.1 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1799.1 Da N = 1
    1817.1 Da N = 2
    1835.1 Da N = 3
    1853.1 Da N = 4
    1871.2 Da N = 5
    1889.2 Da N = 6
D2M30_RS20770 - Class III
  Cleavage pHMM score: 0.00
  RODEO score: 0
  Monoisotopic mass: 1723.0 Da
  Molecular weight: 1724.0 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1742.0 Da N = 1
    1760.0 Da N = 2
    1778.1 Da N = 3
    1796.1 Da N = 4
    1814.1 Da N = 5
    1832.1 Da N = 6
D2M30_RS20775 - Class III
  Cleavage pHMM score: 0.00
  RODEO score: 0
  Monoisotopic mass: 1780.0 Da
  Molecular weight: 1781.1 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1799.1 Da N = 1
    1817.1 Da N = 2
    1835.1 Da N = 3
    1853.1 Da N = 4
    1871.2 Da N = 5
    1889.2 Da N = 6

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ColR | Phenol-responsive regulator
RpoN | Regulator of nitrogen assimilation and virulence
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_CP032146.1 - Region 4 - PKS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 915,929 - 957,173 nt. (total: 41,245 nt) Show pHMM detection rules used
PKS-like: (t2pks2 or ksIII)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
D2M30_RS04755: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acyltransferase aminotransferase
D2M30_RS04785: acyltransferase

smcogs
  SMCOG1141: acyltransferase

D2M30_RS04800: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Hydrolases: deacetylase
D2M30_RS04845: polysaccharide deacetylase

smcogs
  SMCOG1235: polysaccharide deacetylase

Ligases: synthase
D2M30_RS04805: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

Translocases: permease
D2M30_RS04760: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | PKS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002276.2 |  | 0.55 | NRPS | choline | Aspergillus nidulans FGSC A4
BGC0002404.2 |  | 0.45 | other (other) | falcarindiol | Solanum lycopersicum
BGC0002294.3 |  | 0.43 | other (other) | streptozotocin | Streptomyces achromogenes subsp. streptozoticus
BGC0000205.3 |  | 0.43 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0001292.5 |  | 0.42 | other (other) | A33853 | Streptomyces sp. NRRL 12068
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0002150.2 |  | 0.42 | ribosomal | triculamin | Streptomyces triculaminicus
BGC0002151.2 |  | 0.42 | ribosomal | alboverticillin | Streptomyces griseocarneus
BGC0000623.3 |  | 0.42 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0001485.4 |  | 0.42 | other (other) | chuangxinmycin | Actinoplanes tsinanensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002276.2 |  | 0.55 | NRPS | choline | Aspergillus nidulans FGSC A4
BGC0002404.2 |  | 0.45 | other (other) | falcarindiol | Solanum lycopersicum
BGC0002294.3 |  | 0.43 | other (other) | streptozotocin | Streptomyces achromogenes subsp. streptozoticus
BGC0000205.3 |  | 0.43 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0001292.5 |  | 0.42 | other (other) | A33853 | Streptomyces sp. NRRL 12068
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0002150.2 |  | 0.42 | ribosomal | triculamin | Streptomyces triculaminicus
BGC0002151.2 |  | 0.42 | ribosomal | alboverticillin | Streptomyces griseocarneus
BGC0000623.3 |  | 0.42 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0001485.4 |  | 0.42 | other (other) | chuangxinmycin | Actinoplanes tsinanensis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.44 out of 30.25
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.75 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.91 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.88 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.01 out of 26.06
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 24.11 out of 27.55
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.52 out of 26.06
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.44 out of 30.25
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.50 out of 23.79
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.28 out of 26.06
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.02 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.27 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.83 out of 28.19
Confidence: medium
Additional weak hits (13):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.48 out of 29.38
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.02 out of 28.14
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.37 out of 30.25
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.46 out of 29.38
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.28 out of 28.14
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.97 out of 28.14
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 19.83 out of 26.12
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.75 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.41 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.47 out of 26.06
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.63 out of 33.14
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.32 out of 33.14
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.59 out of 30.11
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator
GnfM | Regulator of nitrogen-fixation genes
IolR | Regulator of the inositol catabolism
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_CP032146.1 - Region 5 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,041,867 - 1,062,610 nt. (total: 20,744 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
D2M30_RS05415: oxidoreductase

smcogs
  SMCOG1079: oxidoreductase

Transferases: aminotransferase
D2M30_RS05430: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Hydrolases: hydrolase
D2M30_RS05390: asparagine synthase (glutamine-hydrolyzing)

smcogs
  SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002458.3 |  | 0.49 | NRPS | alazopeptin | Streptacidiphilus griseoplanus
BGC0000885.3 |  | 0.47 | other (other) | 4-hydroxy-3-nitrosobenzamide | Streptomyces murayamaensis
BGC0000846.5 |  | 0.44 | other (other) | tabtoxin | Pseudomonas syringae
BGC0001880.3 |  | 0.43 | ribosomal | scytodecamide | Scytonema sp. UIC 10036
BGC0001374.5 |  | 0.43 | other (other) | thienodolin | Streptomyces albogriseolus
BGC0000502.5 |  | 0.39 | ribosomal | cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7 | Bacillus cereus
BGC0001488.3 |  | 0.39 | other (other) | 4-formylaminooxyvinylglycine | Pseudomonas fluorescens WH6
BGC0000720.3 |  | 0.37 | saccharide | tobramycin | Streptoalloteichus tenebrarius
BGC0001810.3 |  | 0.37 | PKS | trehangelin | Polymorphospora rubra
BGC0001735.5 |  | 0.37 | other (other) | pentostatine, vidarabine | Streptomyces antibioticus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002458.3 |  | 0.49 | NRPS | alazopeptin | Streptacidiphilus griseoplanus
BGC0000885.3 |  | 0.47 | other (other) | 4-hydroxy-3-nitrosobenzamide | Streptomyces murayamaensis
BGC0000846.5 |  | 0.44 | other (other) | tabtoxin | Pseudomonas syringae
BGC0001880.3 |  | 0.43 | ribosomal | scytodecamide | Scytonema sp. UIC 10036
BGC0001374.5 |  | 0.43 | other (other) | thienodolin | Streptomyces albogriseolus
BGC0000502.5 |  | 0.39 | ribosomal | cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7 | Bacillus cereus
BGC0001488.3 |  | 0.39 | other (other) | 4-formylaminooxyvinylglycine | Pseudomonas fluorescens WH6
BGC0000720.3 |  | 0.37 | saccharide | tobramycin | Streptoalloteichus tenebrarius
BGC0001810.3 |  | 0.37 | PKS | trehangelin | Polymorphospora rubra
BGC0001735.5 |  | 0.37 | other (other) | pentostatine, vidarabine | Streptomyces antibioticus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene |  | squalene | C30 | acyclic | none
triterpene | C30 carotenoid | diapophytoene | C30 | acyclic | none
triterpene |  | PSPP | C30 | acyclic | PP
tetraterpene | C40 carotenoid | phytoene | C40 | acyclic | none
triterpene |  | hydroxysqualene | C30 | acyclic | OH

Genes with terpene domains:
D2M30_RS05395: PT_phytoene_like
Domain 1 (4 - 244): Prenyltransferase; Phytoene synthase like
Subtype: unknown

Reactions:
  FPP → squalene
  FPP → diapophytoene
  FPP → PSPP
  GGPP → phytoene
  PSPP → hydroxysqualene

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 23.16 out of 26.33
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.02 out of 26.06
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.27 out of 28.19
Confidence: medium
Additional weak hits (6):
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.05 out of 31.73
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.16 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.08 out of 26.06
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.61 out of 30.22
Confidence: weak
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.99 out of 27.55
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 23.54 out of 35.63
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
FPP | Farnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
PP | Diphosphate
PSPP | Presqualene diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_CP032146.1 - Region 6 - transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,384,092 - 1,472,296 nt. (total: 88,205 nt) Show pHMM detection rules used
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase
D2M30_RS07395: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

D2M30_RS07410: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

D2M30_RS07420: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

D2M30_RS07450: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Transferases: acylase kinase
D2M30_RS07275: PfkB domain protein

smcogs
  SMCOG1276: PfkB domain protein

D2M30_RS07390: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: deacetylase deformylase hydrolase
D2M30_RS07365: hydrolase

smcogs
  SMCOG1179: hydrolase

D2M30_RS07370: peptide deformylase

smcogs
  SMCOG1275: peptide deformylase

D2M30_RS07425: alpha/beta hydrolase fold protein

smcogs
  SMCOG1036: alpha/beta hydrolase fold protein

D2M30_RS07430: beta-lactamase

smcogs
  SMCOG1053: beta-lactamase

D2M30_RS07460: polysaccharide deacetylase

smcogs
  SMCOG1235: polysaccharide deacetylase

Ligases: synthase
D2M30_RS07400: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

D2M30_RS07440: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

D2M30_RS20910: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | transAT-PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000181.5 |  | 0.87 | PKS | macrolactin H | Bacillus velezensis FZB42
BGC0001383.3 |  | 0.86 | PKS | macrolactin H, macrolactin B, macrolactin 1c, macrolactin E | Jeotgalibacillus marinus
BGC0001534.3 |  | 0.70 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0001276.3 |  | 0.64 | PKS | 6-methylsalicyclic acid | Aspergillus terreus
BGC0001164.3 |  | 0.64 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0001275.3 |  | 0.64 | PKS | 6-methylsalicyclic acid | Glarea lozoyensis
BGC0001244.3 |  | 0.64 | PKS | (-)-Mellein | Parastagonospora nodorum
BGC0001160.5 |  | 0.64 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0001273.3 |  | 0.63 | PKS | asperlactone | Aspergillus ochraceus
BGC0001284.4 |  | 0.63 | PKS | alternariol | Parastagonospora nodorum SN15

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000181.5 |  | 0.87 | PKS | macrolactin H | Bacillus velezensis FZB42
BGC0001383.3 |  | 0.86 | PKS | macrolactin H, macrolactin B, macrolactin 1c, macrolactin E | Jeotgalibacillus marinus
BGC0001534.3 |  | 0.70 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0001276.3 |  | 0.64 | PKS | 6-methylsalicyclic acid | Aspergillus terreus
BGC0001164.3 |  | 0.64 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0001275.3 |  | 0.64 | PKS | 6-methylsalicyclic acid | Glarea lozoyensis
BGC0001244.3 |  | 0.64 | PKS | (-)-Mellein | Parastagonospora nodorum
BGC0001160.5 |  | 0.64 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0001273.3 |  | 0.63 | PKS | asperlactone | Aspergillus ochraceus
BGC0001284.4 |  | 0.63 | PKS | alternariol | Parastagonospora nodorum SN15

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.02 out of 27.78
Confidence: medium
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.94 out of 21.55
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.13 out of 20.97
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.45 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.34 out of 26.06
Confidence: medium
Additional weak hits (12):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.30 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.44 out of 26.06
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.27 out of 30.22
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.65 out of 29.25
Confidence: weak
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.35 out of 26.33
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.39 out of 31.73
Confidence: weak
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.49 out of 25.75
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.88 out of 26.12
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.49 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.99 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.18 out of 26.06
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.99 out of 33.14
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 6, location 1384091 - 1472296:
Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:
  (ohmal - ccmal - ccmal) + (ccmal) + (mal) + (ccmal - mal) + (ohmal) + (ohmal - mal)
Non-colinear ordering:
  D2M30_RS07395 + D2M30_RS07400 + D2M30_RS20905 + D2M30_RS20910 + D2M30_RS07410 + D2M30_RS07415 + D2M30_RS07420 + D2M30_RS07425

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
D2M30_RS07390: mal
PKS_AT (4..282): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 75.0%
  inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 82.2
  Methoxymalonyl-CoA: 28.9
  inactive: 28.3
  Methylmalonyl-CoA: 19.0
  Propionyl-CoA: 13.6
  fatty_acid: 11.1
  trans-1,2-CPDA: 0.0
  Isobutyryl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArcA | Repressor of carbon oxidation
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MogR | Repressor of flagellar motility genes

NZ_CP032146.1 - Region 7 - NRPS,T3PKS,transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,690,216 - 1,800,340 nt. (total: 110,125 nt) Show pHMM detection rules used
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxygenase
D2M30_RS08635: alcohol dehydrogenase

smcogs
  SMCOG1040: alcohol dehydrogenase

D2M30_RS08715: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

D2M30_RS08735: cytochrome P450

smcogs
  SMCOG1007: cytochrome P450

Transferases: acylase
D2M30_RS08675: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

D2M30_RS08680: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

D2M30_RS08685: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: hydrolase protease
D2M30_RS08615: beta-lactamase

smcogs
  SMCOG1053: beta-lactamase

D2M30_RS08670: metallo-beta-lactamase family protein

smcogs
  SMCOG1170: metallo-beta-lactamase family protein

D2M30_RS08755: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Lyases: hydratase
D2M30_RS08700: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

D2M30_RS08705: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase
D2M30_RS08640: 8-amino-7-oxononanoate synthase

smcogs
  SMCOG1109: 8-amino-7-oxononanoate synthase

D2M30_RS08695: hydroxymethylglutaryl-CoA synthase

smcogs
  SMCOG1043: hydroxymethylglutaryl-CoA synthase

D2M30_RS08710: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

D2M30_RS08720: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

D2M30_RS08725: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

D2M30_RS08730: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | transAT-PKS | T3PKS | NRPS | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | --- | ---
BGC0001089.5 |  |  |  |  | 1.48 | NRPS, PKS | bacillaene | Bacillus velezensis FZB42
BGC0001160.5 |  |  |  |  | 1.03 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0002135.2 |  |  |  |  | 1.02 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001164.3 |  |  |  |  | 1.01 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0001135.5 |  |  |  |  | 0.97 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001132.4 |  |  |  |  | 0.97 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.4 |  |  |  |  | 0.96 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001833.4 |  |  |  |  | 0.96 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.4 |  |  |  |  | 0.94 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  |  |  |  | 0.94 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001089.5 |  | 0.87 | NRPS, PKS | bacillaene | Bacillus velezensis FZB42
BGC0002135.2 |  | 0.69 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001132.4 |  | 0.69 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.4 |  | 0.69 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001833.4 |  | 0.68 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.4 |  | 0.68 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.67 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  | 0.67 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001758.4 |  | 0.66 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001641.4 |  | 0.65 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.50 out of 27.78
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.78 out of 20.97
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.85 out of 20.97
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.62 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.60 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.29 out of 27.78
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.30 out of 24.78
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.92 out of 24.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.95 out of 28.19
Confidence: medium
Additional weak hits (21):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.51 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.96 out of 26.06
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.16 out of 32.74
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.22 out of 28.14
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.08 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.45 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.06 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.67 out of 26.06
Confidence: weak
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.62 out of 25.75
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.41 out of 30.25
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.04 out of 30.25
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.58 out of 21.55
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.73 out of 30.25
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.61 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.03 out of 26.06
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.39 out of 30.25
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.54 out of 36.54
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 20.38 out of 28.14
Confidence: weak
RicR
Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.62 out of 32.93
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.08 out of 39.62
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 7, location 1690215 - 1800340:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (fatty_acid - Gly - ccmal - ohmal - mal) + (ccmal - mal - ohmal - mal) + (Me-ccmal - ohmal) + (Ala - ccmal - ccmal - Me-ccmal) + (mal - mal)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
D2M30_RS08675: mal
PKS_AT (4..285): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 87.5%
  inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 98.2
  inactive: 43.3
  Methoxymalonyl-CoA: 36.6
  Methylmalonyl-CoA: 24.6
  Propionyl-CoA: 24.5
  2-Methylbutyryl-CoA: 5.7
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Isobutyryl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0

D2M30_RS08680: mal
PKS_AT (7..293): mal
ATSignature: (unknown)
No matches above 50%
minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 29.5
  inactive: 17.0
  Methoxymalonyl-CoA: 11.3
  Benzoyl-CoA: 9.4
  Isobutyryl-CoA: 8.6
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Propionyl-CoA: 0.0
  Methylmalonyl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

D2M30_RS08685: mal
PKS_AT (4..282): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 91.7%
  inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 98.6
  inactive: 30.6
  Methoxymalonyl-CoA: 27.3
  Methylmalonyl-CoA: 14.0
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Propionyl-CoA: 0.0
  Isobutyryl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

D2M30_RS08710: fatty_acid - Gly
Search NORINE for peptide: strict or relaxed
CAL_domain (74..476): fatty_acid
minowa: fatty_acid

Prediction, score:
  fatty_acid: 22.2
  shikimic_acid: 0.0
  NH2: 0.0
  Acetyl-CoA: 0.0
  AHBA: 0.0

AMP-binding (1145..1540): Gly
nrpys: Gly

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    gly (Gly)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FSMTFDIAALELQALCGGEWNMFGPTETTIWSAV
  Nearest Stachelhaus code(s):
    Gly DILQLGMIWK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

D2M30_RS08725: Ala
Search NORINE for peptide: strict or relaxed
AMP-binding (494..898): Ala
nrpys: Ala

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    TFLTFDVSISEGNFMVAGEENIYGPTETSIYAAY
  Nearest Stachelhaus code(s):
    Ala DVSNMAIIYK (88% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 2 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_CP032146.1 - Region 8 - NRPS,betalactone,transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,850,564 - 1,987,202 nt. (total: 136,639 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxygenase
D2M30_RS09270: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

D2M30_RS09285: cytochrome P450

smcogs
  SMCOG1007: cytochrome P450

D2M30_RS09360: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

D2M30_RS09495: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs
  SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: acylase aminotransferase carboxylase transferase
D2M30_RS09260: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

D2M30_RS09305: aminotransferase class-III

smcogs
  SMCOG1013: aminotransferase class-III

D2M30_RS09320: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs
  SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

D2M30_RS09330: acetyl-CoA carboxylase, carboxyl transferase,

smcogs
  SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

D2M30_RS09350: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Hydrolases: peptidase
D2M30_RS09470: gamma-glutamyltranspeptidase

smcogs
  SMCOG1274: gamma-glutamyltranspeptidase

Lyases: hydratase
D2M30_RS09335: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase
D2M30_RS09245: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

D2M30_RS09250: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

D2M30_RS09255: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

D2M30_RS09300: 8-amino-7-oxononanoate synthase

smcogs
  SMCOG1109: 8-amino-7-oxononanoate synthase

D2M30_RS09340: 2-isopropylmalate synthase

smcogs
  SMCOG1271: 2-isopropylmalate synthase

D2M30_RS09355: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

D2M30_RS09375: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

D2M30_RS09380: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

D2M30_RS09385: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

D2M30_RS09390: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

D2M30_RS09395: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | transAT-PKS | NRPS | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | --- | ---
BGC0001833.4 |  |  |  |  | 1.59 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002135.2 |  |  |  |  | 1.58 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001128.4 |  |  |  |  | 1.50 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4 |  |  |  |  | 1.49 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.4 |  |  |  |  | 1.49 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0002286.3 |  |  |  |  | 1.49 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  |  |  |  | 1.47 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001135.5 |  |  |  |  | 1.46 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001095.5 |  |  |  |  | 1.45 | NRPS | fengycin | Bacillus velezensis FZB42
BGC0000402.4 |  |  |  |  | 1.40 | NRPS | paenilarvin A, paenilarvin B, paenilarvin C | Paenibacillus larvae subsp. larvae DSM 25430

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001095.5 |  | 0.89 | NRPS | fengycin | Bacillus velezensis FZB42
BGC0000407.5 |  | 0.81 | NRPS | plipastatin | Bacillus subtilis subsp. subtilis
BGC0000402.4 |  | 0.81 | NRPS | paenilarvin A, paenilarvin B, paenilarvin C | Paenibacillus larvae subsp. larvae DSM 25430
BGC0001090.5 |  | 0.80 | NRPS, PKS | bacillomycin D | Bacillus velezensis FZB42
BGC0001103.5 |  | 0.79 | NRPS, PKS | mycosubtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001098.5 |  | 0.77 | NRPS, PKS | iturin | Bacillus subtilis
BGC0001833.4 |  | 0.75 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001758.4 |  | 0.75 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0002135.2 |  | 0.74 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0002075.3 |  | 0.73 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.21 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.82 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.27 out of 27.78
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.12 out of 23.79
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 20.32 out of 20.97
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.95 out of 27.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 26.66 out of 28.19
Confidence: strong
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 22.20 out of 24.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.30 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.83 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.10 out of 28.19
Confidence: medium
Additional weak hits (17):
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.53 out of 30.25
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.22 out of 28.14
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.65 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.75 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.42 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.65 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.15 out of 26.06
Confidence: weak
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.44 out of 20.47
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.35 out of 26.06
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.41 out of 29.38
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 22.75 out of 35.63
Confidence: weak
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.74 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.51 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.53 out of 26.06
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.12 out of 33.14
Confidence: weak
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 19.67 out of 24.78
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 8, location 1850563 - 1987202:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Glu - D-Orn) + (Tyr - D-Thr) + (Glu - D-X) + (Pro - Gln - D-Tyr) + (Ile) + (fatty_acid - mal - Asn - D-Tyr) + (D-Asn - Gln - Pro - D-Asn) + (Ser)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 9, location 1850563 - 1927809:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (fatty_acid - mal - Asn - D-Tyr) + (D-Asn - Gln - Pro - D-Asn) + (Ser)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 10, location 1909534 - 1987202:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Glu - D-Orn) + (Tyr - D-Thr) + (Glu - D-X) + (Pro - Gln - D-Tyr) + (Ile)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
D2M30_RS09245: Asn - Ser
Search NORINE for peptide: strict or relaxed
AMP-binding (268..663): Asn
nrpys: Asn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asn (Asn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWASFDLTVTSTKLIVGGDFNEYGPTETVVGCMI
  Nearest Stachelhaus code(s):
    Asn DLTKIGEVGK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1778..2185): Ser
nrpys: Ser

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    ser (Ser)
  Single AA prediction:
    ser (Ser)

Stachelhaus prediction details:
  Stachelhaus sequence:
    RWMTFDVSVWEWHFFASGEINLYGPTEATIDVSY
  Nearest Stachelhaus code(s):
    Ser DVWHFSLIDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

D2M30_RS09250: Tyr - Asn - Gln - Pro
Search NORINE for peptide: strict or relaxed
AMP-binding (268..662): Tyr
nrpys: Tyr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    Polar aromatic ring (Tyr, bOH-Tyr)
  Single AA prediction:
    tyr (Tyr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    SWKYFDAFILNGSTVVGGENNEYGPTENSVVSTF
  Nearest Stachelhaus code(s):
    Tyr DALSVGEVVK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1778..2173): Asn
nrpys: Asn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asn (Asn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWASFDLTVTSTKLIVGGECNEYGPTETVVGCMI
  Nearest Stachelhaus code(s):
    Asn DLTKIGEVGK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (3287..3692): Gln
nrpys: Gln

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    gln (Gln)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LGLAFDASVQQADGLIGGETNVYGPTETCVDASL
  Nearest Stachelhaus code(s):
    Gln DAQDLGVVDK (100% 8Å match)
    Ile DAQDLGVVDK (74% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (4334..4730): Pro
nrpys: Pro

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
  Small clusters prediction:
    pro (Pro)
  Single AA prediction:
    pro (Pro)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LYEAFDVCYQESFLIAAGEHNHYGPSETHVVTMY
  Nearest Stachelhaus code(s):
    Pro DVQFIAHVVK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

D2M30_RS09255: fatty_acid - Asn
Search NORINE for peptide: strict or relaxed
CAL_domain (36..478): fatty_acid
minowa: fatty_acid

Prediction, score:
  fatty_acid: 614.1
  NH2: 18.8
  shikimic_acid: 0.0
  Acetyl-CoA: 0.0
  AHBA: 0.0

AMP-binding (2956..3351): Asn
nrpys: Asn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asn (Asn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWASFDLTVTSTKLIVGGEFNEYGPTETVVGCMI
  Nearest Stachelhaus code(s):
    Asn DLTKIGEVGK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

D2M30_RS09260: mal
PKS_AT (6..291): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 62.5%
  inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 71.0
  inactive: 30.7
  Methoxymalonyl-CoA: 18.6
  Propionyl-CoA: 10.2
  Methylmalonyl-CoA: 10.0
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Isobutyryl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

D2M30_RS09355: X
AMP-binding (12..445): X
nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:
  Predicted physicochemical class:
    N/A
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    NNIVF-GCVLGAHGIMAGSTIAYGQTEASPVITQ
  Nearest Stachelhaus code(s):
    Z-ahmohOrn FGLHIASTCK (56% 8Å match)
    Ile DGLFIGIPVK (32% 8Å match)
  Stachelhaus code match:
    60% (weak)

D2M30_RS09375: Ile
Search NORINE for peptide: strict or relaxed
AMP-binding (473..866): Ile
nrpys: Ile

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    ile (Ile)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LNSGFDAVTFEGFLYVGGEYNIYGPTENTTFSTF
  Nearest Stachelhaus code(s):
    Ile DAFFYGITFK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

D2M30_RS09380: Pro - Gln - Tyr
Search NORINE for peptide: strict or relaxed
AMP-binding (469..866): Pro
nrpys: Pro

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
  Small clusters prediction:
    pro (Pro)
  Single AA prediction:
    pro (Pro)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LDQAFDVCYQESFFITAGEHNHYGPSETHVVSTY
  Nearest Stachelhaus code(s):
    Pro DVQFIAHVVK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1500..1901): Gln
nrpys: Gln

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    glu (Glu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FSLTFDASIWEWHFFAGGETNSYGPTEATVEAAY
  Nearest Stachelhaus code(s):
    Gln DAWHFGSVEK (100% 8Å match)
    Glu DAWHFGSVEK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (2532..2924): Tyr
nrpys: Tyr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    Polar aromatic ring (Tyr, bOH-Tyr)
  Single AA prediction:
    tyr (Tyr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TWRFFDGFVTSTIITLAGEANEYGPTENSVATTA
  Nearest Stachelhaus code(s):
    Tyr DGTITAEVAK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

D2M30_RS09385: Glu - X
Search NORINE for peptide: strict or relaxed
AMP-binding (469..873): Glu
nrpys: Glu

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    glu (Glu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FGMSFDASIWQWHFFAGGEIHGYGPTEATVDAAF
  Nearest Stachelhaus code(s):
    Glu DAWHFGGVDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1505..1898): X
nrpys: Ala, Val

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    val (Val)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LNSSFDVTTFEGWLIIGGEWNGYGPTENTTFSTC
  Nearest Stachelhaus code(s):
    Ala or Val DVFWIGGTFK (97% 8Å match)
    Val DVFWIGGTFK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

D2M30_RS09390: Tyr - Thr
Search NORINE for peptide: strict or relaxed
AMP-binding (473..866): Tyr
nrpys: Tyr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    Polar aromatic ring (Tyr, bOH-Tyr)
  Single AA prediction:
    tyr (Tyr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TWRFFDGSLTSTLITFAGELNEYGPTENSVATTI
  Nearest Stachelhaus code(s):
    Tyr DGTLTAEVAK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1508..1904): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LHKHFDFSVWEGNQIFGGEVNMYGITETTVHVTC
  Nearest Stachelhaus code(s):
    Thr DFWNIGMVHK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

D2M30_RS09395: Glu - Orn
Search NORINE for peptide: strict or relaxed
AMP-binding (464..868): Glu
nrpys: Glu

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    glu (Glu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FGMSFDASIWQWHFFAGGEIHGYGPTEATVDAAF
  Nearest Stachelhaus code(s):
    Glu DAWHFGGVDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1500..1905): Orn
nrpys: Orn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Long positively charged side chain (Orn, Lys, Arg)
  Small clusters prediction:
    Orn and hydroxy-Orn specific (Orn, OH-Orn)
  Single AA prediction:
    orn (Orn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    AAWAFDVFSGDRESVLGSDINSYGVTEATIDSSY
  Nearest Stachelhaus code(s):
    Orn DVGEVGSIDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
IolR | Regulator of the inositol catabolism
LexA variant 2 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_CP032146.1 - Region 9 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,020,975 - 2,042,858 nt. (total: 21,884 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
D2M30_RS09745: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

Hydrolases: hydrolase
D2M30_RS09770: metallo-beta-lactamase family protein

smcogs
  SMCOG1170: metallo-beta-lactamase family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002173.2 |  | 0.47 | saccharide, terpene | fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol | Aspergillus fumigatus A1163
BGC0001535.3 |  | 0.42 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0000313.4 |  | 0.36 | NRPS | beauvericin | Beauveria bassiana
BGC0002255.3 |  | 0.33 | PKS | lijiquinone | Ascomycota sp. F53
BGC0000663.5 |  | 0.30 | terpene | hopene | Streptomyces coelicolor A3(2)
BGC0000686.3 |  | 0.30 | terpene | helvolic acid | Aspergillus fumigatus Af293
BGC0001575.4 |  | 0.29 | NRPS | PZN5, PZN6, PZN7, PZN9, PZN10, PZN11 | Ruminococcus sp. 5_1_39BFAA
BGC0001338.4 |  | 0.28 | PKS | citrinin | Monascus ruber
BGC0000154.4 |  | 0.28 | PKS | stipitatic acid | Talaromyces stipitatus ATCC 10500
BGC0001739.3 |  | 0.28 | other (other) | phosphonoacetic Acid | Streptomyces sp. NRRL F-525

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002173.2 |  | 0.47 | saccharide, terpene | fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol | Aspergillus fumigatus A1163
BGC0001535.3 |  | 0.42 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0000313.4 |  | 0.36 | NRPS | beauvericin | Beauveria bassiana
BGC0002255.3 |  | 0.33 | PKS | lijiquinone | Ascomycota sp. F53
BGC0000663.5 |  | 0.30 | terpene | hopene | Streptomyces coelicolor A3(2)
BGC0000686.3 |  | 0.30 | terpene | helvolic acid | Aspergillus fumigatus Af293
BGC0001575.4 |  | 0.29 | NRPS | PZN5, PZN6, PZN7, PZN9, PZN10, PZN11 | Ruminococcus sp. 5_1_39BFAA
BGC0001338.4 |  | 0.28 | PKS | citrinin | Monascus ruber
BGC0000154.4 |  | 0.28 | PKS | stipitatic acid | Talaromyces stipitatus ATCC 10500
BGC0001739.3 |  | 0.28 | other (other) | phosphonoacetic Acid | Streptomyces sp. NRRL F-525

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene | hopanoid |  | C30 | hopanoid skeleton | unknown
triterpene | polypodane |  | C30 | polypodane skeleton | unknown

Genes with terpene domains:
D2M30_RS09750: T2TS
Domain 1 (5 - 624): Type 2 terpene synthase
Subtype: Squalene substrate

Reactions:
  squalene → hopanoid
  squalene → polypodane

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.14 out of 18.16
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.53 out of 26.06
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.26 out of 27.78
Confidence: medium
Additional weak hits (4):
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.62 out of 21.55
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.67 out of 26.06
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.10 out of 29.25
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.14 out of 39.62
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.
No acronyms to display
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis

NZ_CP032146.1 - Region 10 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,097,950 - 2,139,050 nt. (total: 41,101 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: acetyltransferase methyltransferase
D2M30_RS10275: isoprenylcysteine carboxyl methyltransferase

smcogs
  SMCOG1150: isoprenylcysteine carboxyl methyltransferase

D2M30_RS10285: GCN5-related N-acetyltransferase

smcogs
  SMCOG1111: GCN5-related N-acetyltransferase

Ligases: synthase
D2M30_RS10280: chalcone and stilbene synthase domain protein

smcogs
  SMCOG1024: chalcone and stilbene synthase domain protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000282.3 |  | 0.55 | PKS | 2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3 |  | 0.51 | PKS | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0002332.2 |  | 0.44 | PKS | 4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A | Candidatus Entotheonella sp.
BGC0001475.4 |  | 0.43 | terpene | aspterric acid | Aspergillus terreus NIH2624
BGC0001289.5 |  | 0.35 | ribosomal | penisin | Paenibacillus ehimensis
BGC0001647.3 |  | 0.34 | PKS | lagunapyrone A, lagunapyrone B, lagunapyrone C | Streptomyces sp. MP131-18
BGC0001928.2 |  | 0.32 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0001964.2 |  | 0.32 | PKS | alkylpyrone-407, alkylpyrone-393 | Cystobacterineae bacterium
BGC0002254.3 |  | 0.31 | PKS | notoamide F, (+)-semivioxanthin, waikikiamide B, waikikiamide C, notoamide A, waikikiamide A | Aspergillus sp. FM242
BGC0001663.3 |  | 0.30 | PKS | merocyclophane C, merocyclophane D | Nostoc sp. UIC 10110

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000282.3 |  | 0.55 | PKS | 2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3 |  | 0.51 | PKS | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0002332.2 |  | 0.44 | PKS | 4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A | Candidatus Entotheonella sp.
BGC0001475.4 |  | 0.43 | terpene | aspterric acid | Aspergillus terreus NIH2624
BGC0001289.5 |  | 0.35 | ribosomal | penisin | Paenibacillus ehimensis
BGC0001647.3 |  | 0.34 | PKS | lagunapyrone A, lagunapyrone B, lagunapyrone C | Streptomyces sp. MP131-18
BGC0001928.2 |  | 0.32 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0001964.2 |  | 0.32 | PKS | alkylpyrone-407, alkylpyrone-393 | Cystobacterineae bacterium
BGC0002254.3 |  | 0.31 | PKS | notoamide F, (+)-semivioxanthin, waikikiamide B, waikikiamide C, notoamide A, waikikiamide A | Aspergillus sp. FM242
BGC0001663.3 |  | 0.30 | PKS | merocyclophane C, merocyclophane D | Nostoc sp. UIC 10110

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 27.26 out of 29.38
Confidence: strong
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.48 out of 23.79
Confidence: strong
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.67 out of 21.55
Confidence: medium
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.26 out of 21.55
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 25.16 out of 28.19
Confidence: strong
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.73 out of 28.19
Confidence: strong
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.47 out of 20.01
Confidence: medium
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.57 out of 25.31
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.38 out of 26.06
Confidence: medium
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.73 out of 29.25
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.84 out of 29.38
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.21 out of 30.25
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.89 out of 18.16
Confidence: strong
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.38 out of 24.78
Confidence: medium
Additional weak hits (6):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.23 out of 29.38
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.58 out of 29.38
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 26.01 out of 32.74
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.09 out of 30.25
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.03 out of 30.25
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.02 out of 29.65
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
ArcA | Repressor of carbon oxidation
ArgR | Regulator of arginine biosynthesis genes
CatR | H2O2-responsive repressor
ColR | Phenol-responsive regulator
FuR variant 1 | Ferric Uptake Regulator
IolR | Regulator of the inositol catabolism
LexA variant 2 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
SypG | Regulator of biofilm formation and host colonization
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_CP032146.1 - Region 11 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,456,995 - 2,477,885 nt. (total: 20,891 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: carboxylase
D2M30_RS12385: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase
D2M30_RS12350: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

D2M30_RS12355: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002284.3 |  | 0.38 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000639.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0000638.3 |  | 0.37 | terpene | carotenoid | Pantoea ananatis
BGC0000640.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC404

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002284.3 |  | 0.38 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000639.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0000638.3 |  | 0.37 | terpene | carotenoid | Pantoea ananatis
BGC0000640.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC404

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
D2M30_RS12355: PT_FPPS_like
Domain 1 (33 - 296): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  DMAPP, IPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.14 out of 27.78
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.59 out of 30.25
Confidence: medium
Additional weak hits (1):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.48 out of 26.06
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator

NZ_CP032146.1 - Region 12 - NRP-metallophore,NRPS,terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,068,972 - 3,134,235 nt. (total: 65,264 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)
NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase reductase
D2M30_RS15750: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

D2M30_RS15825: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

D2M30_RS15875: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

D2M30_RS15885: alkyl hydroperoxide reductase subunit

smcogs
  SMCOG1176: alkyl hydroperoxide reductase subunit

D2M30_RS15900: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

D2M30_RS15925: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Hydrolases: esterase hydrolase
D2M30_RS15665: thioesterase superfamily protein

smcogs
  SMCOG1144: thioesterase superfamily protein

D2M30_RS15715: isochorismatase

smcogs
  SMCOG1027: isochorismatase

D2M30_RS15810: isochorismatase

smcogs
  SMCOG1027: isochorismatase

Isomerases: isomerase
D2M30_RS15820: isochorismate synthase

smcogs
  SMCOG1018: isochorismate synthase

Ligases: ligase synthetase
D2M30_RS15685: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

D2M30_RS15805: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

D2M30_RS15815: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | NRP-metallophore | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | ---
BGC0001185.5 |  |  |  | 1.40 | NRPS | bacillibactin | Bacillus velezensis FZB42
BGC0000309.5 |  |  |  | 1.05 | NRPS | bacillibactin | Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5 |  |  |  | 1.04 | NRPS | paenibactin | Paenibacillus elgii B69
BGC0002075.3 |  |  |  | 0.87 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0000343.5 |  |  |  | 0.86 | NRPS | enterobactin | Pseudomonas sp. J465
BGC0001132.4 |  |  |  | 0.77 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  |  |  | 0.76 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  |  |  | 0.75 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001128.4 |  |  |  | 0.73 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  |  |  | 0.73 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001185.5 |  | 0.89 | NRPS | bacillibactin | Bacillus velezensis FZB42
BGC0000309.5 |  | 0.80 | NRPS | bacillibactin | Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5 |  | 0.80 | NRPS | paenibactin | Paenibacillus elgii B69
BGC0002075.3 |  | 0.74 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0000343.5 |  | 0.74 | NRPS | enterobactin | Pseudomonas sp. J465
BGC0001132.4 |  | 0.71 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  | 0.70 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  | 0.70 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001128.4 |  | 0.69 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  | 0.69 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP
diterpene precursor |  | GGPP | C20 | acyclic | PP
sesterterpene precursor |  | GFPP | C25 | acyclic | PP
triterpene precursor |  | HPP | C30 | acyclic | PP

Genes with terpene domains:
D2M30_RS15685: PT_FPPS_like
Domain 1 (43 - 297): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: unknown

Reactions:
  IPP, DMAPP → FPP
  IPP, DMAPP → GGPP
  IPP, DMAPP → GFPP
  IPP, DMAPP → HPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 29.38 out of 29.38
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.61 out of 29.38
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 27.15 out of 29.38
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.49 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.52 out of 27.78
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.49 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.91 out of 29.38
Confidence: medium
NtrC
Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 23.25 out of 29.72
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.52 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.97 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.08 out of 26.06
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.73 out of 28.19
Confidence: strong
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.18 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.81 out of 28.19
Confidence: medium
Additional weak hits (22):
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.98 out of 27.55
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.88 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.45 out of 26.06
Confidence: weak
DosR
Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 22.13 out of 29.51
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.39 out of 31.73
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.44 out of 31.73
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.84 out of 29.25
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.61 out of 32.74
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.12 out of 29.38
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.52 out of 32.74
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.31 out of 29.38
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.58 out of 26.06
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 21.95 out of 31.73
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.64 out of 31.73
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.85 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.41 out of 26.06
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.11 out of 33.14
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 21.63 out of 30.12
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.56 out of 33.14
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
Terpene
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 14, location 3068971 - 3134235:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 16, location 3082507 - 3134235:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
D2M30_RS15805: Gly - Thr
Search NORINE for peptide: strict or relaxed
AMP-binding (456..855): Gly
nrpys: Gly

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    gly (Gly)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FSMTFDISGLELQALVGGETNLYGPTETTIWSAA
  Nearest Stachelhaus code(s):
    Gly DILQLGLIWK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1513..1929): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LSTHFDFSVWEGNQIFGGEVNMYGITETTVHVSY
  Nearest Stachelhaus code(s):
    Thr DFWNIGMVHK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

D2M30_RS15815: diOH-Bz
Search NORINE for peptide: strict or relaxed
AMP-binding (31..435): diOH-Bz
nrpys: diOH-Bz

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Small clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Single AA prediction:
    dhb (diOH-Bz)

Stachelhaus prediction details:
  Stachelhaus sequence:
    SLSLYPLSSPGGALQVGGAQQVFGMAEGLVNYTR
  Nearest Stachelhaus code(s):
    diOH-Bz PLPAQGVVNK (97% 8Å match)
    diOH-Bz or Sal PLPAQGVVNK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
GFPP | Geranylfarnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
HPP | Hexaprenyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1 | Ferric Uptake Regulator
MogR | Repressor of flagellar motility genes
NtrC | Nitrogen regulatory protein C
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_CP032146.1 - Region 13 - other
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,642,979 - 3,684,397 nt. (total: 41,419 nt) Show pHMM detection rules used
other: (Neocarzinostat or bcpB or frbD or mitE or prnB or CaiA or bacilysin or orf2_PTase)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
D2M30_RS18685: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

D2M30_RS18705: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: aminotransferase transferase
D2M30_RS18690: aminotransferase

smcogs
  SMCOG1019: aminotransferase

D2M30_RS18770: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs
  SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

D2M30_RS18795: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs
  SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

Lyases: dehydratase lyase
D2M30_RS18700: argininosuccinate lyase/adenylosuccinate lyase

smcogs
  SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

D2M30_RS18760: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

D2M30_RS18765: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

Translocases: permease
D2M30_RS18595: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

D2M30_RS18730: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | other | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000888.5 |  | 0.94 | other (other) | bacilysin | Bacillus sp. CS93
BGC0001184.4 |  | 0.94 | other (other) | bacilysin | Bacillus velezensis FZB42
BGC0000898.5 |  | 0.56 | saccharide | desosamine, pikromycin, neomethymycin, narbomycin | Streptomyces venezuelae
BGC0000790.3 |  | 0.55 | saccharide | O-antigen | Escherichia coli
BGC0000773.3 |  | 0.55 | saccharide | lipopolysaccharide | Escherichia coli
BGC0000791.3 |  | 0.54 | saccharide | O-antigen | Cronobacter sakazakii
BGC0000794.5 |  | 0.53 | saccharide | S-layer glycan | Geobacillus stearothermophilus
BGC0000795.3 |  | 0.52 | saccharide | S-layer glycan | Aneurinibacillus thermoaerophilus
BGC0001817.5 |  | 0.52 | other (other) | vancosamine | Streptomyces sp. WAC2288
BGC0000899.4 |  | 0.52 | saccharide | desosamine | Streptomyces narbonensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000888.5 |  | 0.94 | other (other) | bacilysin | Bacillus sp. CS93
BGC0001184.4 |  | 0.94 | other (other) | bacilysin | Bacillus velezensis FZB42
BGC0000898.5 |  | 0.56 | saccharide | desosamine, pikromycin, neomethymycin, narbomycin | Streptomyces venezuelae
BGC0000790.3 |  | 0.55 | saccharide | O-antigen | Escherichia coli
BGC0000773.3 |  | 0.55 | saccharide | lipopolysaccharide | Escherichia coli
BGC0000791.3 |  | 0.54 | saccharide | O-antigen | Cronobacter sakazakii
BGC0000794.5 |  | 0.53 | saccharide | S-layer glycan | Geobacillus stearothermophilus
BGC0000795.3 |  | 0.52 | saccharide | S-layer glycan | Aneurinibacillus thermoaerophilus
BGC0001817.5 |  | 0.52 | other (other) | vancosamine | Streptomyces sp. WAC2288
BGC0000899.4 |  | 0.52 | saccharide | desosamine | Streptomyces narbonensis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Location:
Identifier
Identity
Coverage
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.22 out of 18.46
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.67 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.85 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.67 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.62 out of 27.78
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.12 out of 30.25
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.63 out of 27.78
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.12 out of 23.79
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.75 out of 29.38
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.45 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.75 out of 28.19
Confidence: medium
Additional weak hits (7):
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.37 out of 20.01
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 21.90 out of 31.73
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.67 out of 26.06
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.91 out of 28.14
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.32 out of 26.06
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.37 out of 39.62
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.68 out of 33.14
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator
FuR variant 1 | Ferric Uptake Regulator
IolR | Regulator of the inositol catabolism
MogR | Repressor of flagellar motility genes
RpoN | Regulator of nitrogen assimilation and virulence
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor