GCF_003796805.1 - 5 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_RKNR01000012.1 (Enterococcus durans)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 3.1	lanthipeptide-class-ii,cyclic-lactone-autoinducer	1	30,563	Low	thusin	ribosomal:RiPP

NZ_RKNR01000001.1 (Enterococcus durans)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 11.1	terpene-precursor	117,430	138,314

NZ_RKNR01000002.1 (Enterococcus durans)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 21.1	T3PKS	320,563	359,668

NZ_RKNR01000007.1 (Enterococcus durans)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 26.1	terpene	77,036	97,926

NZ_RKNR01000009.1 (Enterococcus durans)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 28.1	cyclic-lactone-autoinducer	1	16,627

No secondary metabolite regions were found in these records:: NZ_RKNR01000010.1 (Enterococcus durans); NZ_RKNR01000011.1 (Enterococcus durans); NZ_RKNR01000013.1 (Enterococcus durans); NZ_RKNR01000014.1 (Enterococcus durans); NZ_RKNR01000015.1 (Enterococcus durans); NZ_RKNR01000016.1 (Enterococcus durans); NZ_RKNR01000017.1 (Enterococcus durans); NZ_RKNR01000018.1 (Enterococcus durans); NZ_RKNR01000019.1 (Enterococcus durans); NZ_RKNR01000020.1 (Enterococcus durans); NZ_RKNR01000021.1 (Enterococcus durans); NZ_RKNR01000022.1 (Enterococcus durans); NZ_RKNR01000023.1 (Enterococcus durans); NZ_RKNR01000024.1 (Enterococcus durans); NZ_RKNR01000025.1 (Enterococcus durans); NZ_RKNR01000026.1 (Enterococcus durans); NZ_RKNR01000027.1 (Enterococcus durans); NZ_RKNR01000028.1 (Enterococcus durans); NZ_RKNR01000003.1 (Enterococcus durans); NZ_RKNR01000004.1 (Enterococcus durans); NZ_RKNR01000005.1 (Enterococcus durans); NZ_RKNR01000006.1 (Enterococcus durans); NZ_RKNR01000008.1 (Enterococcus durans)

Compact view

NZ_RKNR01000012.1 - Region 1 - cyclic-lactone-autoinducer,lanthipeptide-class-ii

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Location: 1 - 30,563 nt. (total: 30,563 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

EGW35_RS11590: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

EGW35_RS11610: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000623.3	0.44	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000525.5	0.42	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0002110.3	0.41	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000520.5	0.41	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0000539.5	0.40	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0000555.3	0.39	ribosomal	staphylococcin C55 α, staphylococcin C55 β	Staphylococcus aureus
BGC0001391.3	0.39	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000500.5	0.39	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0001311.5	0.37	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0001229.4	0.37	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002110.3	0.56	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000623.3	0.55	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000626.3	0.55	ribosomal	thuricin	Bacillus thuringiensis
BGC0000500.5	0.55	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000555.3	0.55	ribosomal	staphylococcin C55 α, staphylococcin C55 β	Staphylococcus aureus
BGC0000552.3	0.55	ribosomal	SmbA, SmbB	Streptococcus mutans
BGC0000520.5	0.55	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0001311.5	0.54	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0000539.5	0.54	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0000525.5	0.53	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for EGW35_RS11590

EGW35_RS11615

Leader:

MNKRDAFETYQEKGNLKEMSPMMEEEIMDIETEIQAG

Core:

CTTNTFSLSDYLGNTGGWCTATKECMPSCN

Core with dehydrations:

CysDhbDhbNDhbFDhaLDhaDYLGNDhbGGWCysDhbADhbKECysMPDhaCysN

antiSMASH-DB 4.0 matches for EGW35_RS11615

88.2%

NZ_CP042598.1and 2 others:

NZ_RKNR01000012.1 Lanthipeptides: EGW35_RS11615_lanthipeptideNZ_RKNR01000012.1 Lanthipeptides: EGW35_RS11615_lanthipeptide

Lanthipeptides: FUT28_RS13825_lanthipeptide

CTTNTFSLSDYLGNTGGWCTATKECMPSCN

85.3%

NZ_JADPDT010000005.1and 1 other:

NZ_JADPDT010000005.1 Lanthipeptides: I4V19_RS09885_lanthipeptide

Lanthipeptides: I4V19_RS09885_lanthipeptide

CTTNTFSLSDYLGNTGGWCTATKECMPSCN

CTTNTFSLSD+LGNTGGWCTATKECMPSCN

CTTNTFSLSDFLGNTGGWCTATKECMPSCN

83.3%

NZ_BMMP01000005.1and 3 others:

NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS28370_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptide

Lanthipeptides: IEY56_RS28370_lanthipeptide

CTTNTFSLSDYLGNTGGWCTATKECMPSCN

CTTNTFSLSD LGNTGGWCT T EC P+CN

CTTNTFSLSDVLGNTGGWCTLTVECQPNCN

with 105 more sequence matches

Only the first 10 are displayed here.

83.3%

NZ_BNBV01000031.1and 1 other:

NZ_BNBV01000031.1 Lanthipeptides: IE286_RS22995_lanthipeptide

Lanthipeptides: IE286_RS22995_lanthipeptide

CTTNTFSLSDYLGNTGGWCTATKECMPSCN

CTTNTFSLSD LGN+GGWCT TKEC P+CN

CTTNTFSLSDALGNSGGWCTLTKECQPNCN

83.3%

NZ_CP107567.1and 3 others:

NZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptide

Lanthipeptides: OGH68_RS19760_lanthipeptide

CTTNTFSLSDYLGNTGGWCTATKECMPSCN

CTTNTFSLSD+LGN GGWCT TKEC P+CN

CTTNTFSLSDWLGNQGGWCTLTKECQPNCN

83.3%

NZ_LT985747.1and 1 other:

NZ_LT985747.1 Lanthipeptides: C8268_RS00165_lanthipeptide

Lanthipeptides: C8268_RS00165_lanthipeptide

CTTNTFSLSDYLGNTGGWCTATKECMPSCN

CTTNTF+LSDYLGN GGWCT TKEC SCN

CTTNTFTLSDYLGNKGGWCTLTKECQRSCN

80.0%

NZ_AKXV01000031.1and 4 others:

NZ_AKXV01000031.1 Lanthipeptides: Y19_RS0109895_lanthipeptideNZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13545_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptideNZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide

Lanthipeptides: Y19_RS0109895_lanthipeptide

CTTNTFSLSDYLGNTGGWCTATKECMPSCN

C+TNTFSLSD+LGN GGWCT TKEC P+CN

CSTNTFSLSDFLGNQGGWCTLTKECQPNCN

80.0%

NZ_BJTV01000004.1and 1 other:

NZ_BJTV01000004.1 Lanthipeptides: TNCT1_RS10200_lanthipeptide

Lanthipeptides: TNCT1_RS10200_lanthipeptide

CTTNTFSLSDYLGNTGGWCTATKECMPSCN

CTTNTFSLSD LGN GGWCT TKEC +CN

CTTNTFSLSDALGNHGGWCTLTKECQANCN

80.0%

NZ_BNCA01000011.1and 1 other:

NZ_BNCA01000011.1 Lanthipeptides: IE314_RS15865_lanthipeptide

Lanthipeptides: IE314_RS15865_lanthipeptide

CTTNTFSLSDYLGNTGGWCTATKECMPSCN

CTTNTFSLSD +GN GGWCT TKEC P+CN

CTTNTFSLSDAVGNHGGWCTLTKECQPNCN

80.0%

NZ_CP016795.1and 5 others:

NZ_CP016795.1 Lanthipeptides: BC342_RS18360_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptideNZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptideNZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptide

Lanthipeptides: BC342_RS18360_lanthipeptide

CTTNTFSLSDYLGNTGGWCTATKECMPSC

CTTNTFSLSD LGN GGWCT TKEC P+C

CTTNTFSLSDALGNHGGWCTLTKECQPNC

80.0%

NZ_CP043317.1and 1 other:

NZ_CP043317.1 Lanthipeptides: FYC74_RS17680_lanthipeptide

Lanthipeptides: FYC74_RS17680_lanthipeptide

CTTNTFSLSDYLGNTGGWCTATKECMPSC

CTTNTFSLSD LGN GGWCT TKEC P+C

CTTNTFSLSDSLGNHGGWCTLTKECQPNC

80.0%

NZ_CP061868.1and 1 other:

NZ_CP061868.1 Lanthipeptides: IE339_RS06330_lanthipeptide

Lanthipeptides: IE339_RS06330_lanthipeptide

CTTNTFSLSDYLGNTGGWCTATKECMPSCN

CTTNTFSLSDY GN GGWCTAT ECM C

CTTNTFSLSDYWGNKGGWCTATHECMSWCK

80.0%

NZ_CP084530.1and 1 other:

NZ_CP084530.1 Lanthipeptides: LDO05_RS02075_lanthipeptide

Lanthipeptides: LDO05_RS02075_lanthipeptide

CTTNTFSLSDYLGNTGGWCTATKECMPSCN

CTTNTF+LS+YLGN GGWCT TKEC SCN

CTTNTFTLSNYLGNNGGWCTLTKECQRSCN

MIBiG 4.0 matches for EGW35_RS11615

80.0%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

CTTNTFSLSDYLGNTGGWCTATKECMPSCN

CTTNTFSLS+ LGN GGWCT TKEC P+CN

CTTNTFSLSNALGNNGGWCTLTKECQPNCN

50.0%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

FSLSDYLGNTGGWCTATKECMPSCN

+++S LGN G +CT T ECMPSCN

YNISCRLGNKGAYCTLTVECMPSCN

20.5%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

CTATKECMPSCN

CT +KEC P+CN

CTLSKECQPNCN

EGW35_RS11625

Leader:

MFTKNEKFEHNQEEESILEEISESEDTNGG

Core:

TTWACVAVSTIVDASISLCPTTKCTSQCS

Core with dehydrations:

DhbDhbWACysVAVDhaDhbIVDADhaIDhaLCysPDhbDhbKCysDhbDhaQCysDha

antiSMASH-DB 4.0 matches for EGW35_RS11625

100.0%

NZ_CP042598.1and 3 others:

NZ_CP042598.1 Lanthipeptides: FUT28_RS13815_lanthipeptideNZ_RKNR01000012.1 Lanthipeptides: EGW35_RS11625_lanthipeptideNZ_RKNR01000012.1 Lanthipeptides: EGW35_RS11625_lanthipeptide

Lanthipeptides: FUT28_RS13815_lanthipeptide

TTWACVAVSTIVDASISLCPTTKCTSQCS

89.7%

NZ_JADPDT010000005.1and 1 other:

NZ_JADPDT010000005.1 Lanthipeptides: I4V19_RS09875_lanthipeptide

Lanthipeptides: I4V19_RS09875_lanthipeptide

TTWACVAVSTIVDASISLCPTTKCTSQCS

TTWACVAVST+V+ASISLCPTTKCTS+CS

TTWACVAVSTVVEASISLCPTTKCTSKCS

69.0%

NZ_JABBGE010000004.1and 1 other:

NZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13570_lanthipeptide

Lanthipeptides: HHL19_RS13570_lanthipeptide

TTWACV---AVSTIVDASISLCPTTKCTSQC

TTW+C AV+T+V AS CPTTKCTSQC

TTWSCAVVTAVATLVSASA--CPTTKCTSQC

with 90 more sequence matches

Only the first 10 are displayed here.

69.0%

NZ_LMEI01000006.1and 1 other:

NZ_LMEI01000006.1 Lanthipeptides: ASC82_RS30550_lanthipeptide

Lanthipeptides: ASC82_RS30550_lanthipeptide

TTWACV---AVSTIVDASISLCPTTKCTSQC

TTW+C AV+T+V AS CPTTKCTSQC

TTWSCAIVTAVATLVSAS--ACPTTKCTSQC

58.6%

NZ_LT630004.1:

Lanthipeptides: BQ5796_RS18310_lanthipeptide

TTWACVAVSTIVDASISLCPTTKCTSQC

TT CV ++ V S+S+CPTTKCTSQC

TTLPCVGIT--VTISVSMCPTTKCTSQC

48.5%

NZ_QORY01000016.1and 1 other:

NZ_QORY01000016.1 Lanthipeptides: DT250_RS18265_lanthipeptide

Lanthipeptides: DT250_RS18265_lanthipeptide

TTWACVAVSTIVDASISLCPTTKCTSQC

TTW C A+ TI AS + CPTT C+S+C

TTWGC-AIFTI--ASAAQCPTTACSSKC

45.7%

NZ_CM000721.1and 9 others:

NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptideNZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide

Lanthipeptides: BCERE0010_RS29355_lanthipeptide

AVSTIVDASI----SLCPTTKCTSQC

A TI+ A+I SLCPTTKCTS+C

ATPTIIGATIAVTASLCPTTKCTSRC

45.7%

NZ_CP015591.1and 15 others:

NZ_CP078085.1 Lanthipeptides: KU891_RS29355_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29350_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29345_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29340_lanthipeptideNZ_CP078085.1 Lanthipeptides: KU891_RS29335_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptideNZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptideNZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptide

Lanthipeptides: A7A70_RS27550_lanthipeptide

AVSTIVDASI----SLCPTTKCTSQC

A TIV+A+I S+CPTTKCTS+C

ATPTIVEATIAATVSICPTTKCTSRC

45.2%

NC_018499.1and 5 others:

NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27845_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide

Lanthipeptides: BCK_RS27845_lanthipeptide

AVSTIVDASISLCPTTKCTSQC

A TIV S+ +CPTTKCTS+C

ATPTIVAVSLGICPTTKCTSKC

44.8%

NZ_BIFH01000022.1and 1 other:

NZ_BIFH01000022.1 Lanthipeptides: EMA17_RS52585_lanthipeptide

Lanthipeptides: EMA17_RS52585_lanthipeptide

TTWACVAVSTIVDASISLCPTTKCTSQC

T+ CVA T++ A+ +CPTT C+S+C

TSALCVATITLITAT--MCPTTACSSKC

43.5%

NZ_AKXV01000031.1and 1 other:

NZ_AKXV01000031.1 Lanthipeptides: Y19_RS44045_lanthipeptide

Lanthipeptides: Y19_RS44045_lanthipeptide

TTWACV---AVSTIVDASISLCPTTKCTSQC

TTW+C AV+T+V AS CPTTKCTSQC

TTWSCAIVTAVATLVSASA--CPTTKCTSQC

41.4%

NZ_LR134483.1and 1 other:

NZ_LR134483.1 Lanthipeptides: EL241_RS13590_lanthipeptide

Lanthipeptides: EL241_RS13590_lanthipeptide

VDASISLCPTTKCTSQC

V SI+LCPT KCTS+C

VPLSIALCPTAKCTSKC

41.0%

NZ_CP009280.1and 1 other:

NZ_CP009280.1 Lanthipeptides: P40081_RS37160_lanthipeptide

Lanthipeptides: P40081_RS37160_lanthipeptide

TTWACVAVSTIVDASISLCPTTKCTSQC

++W CV + VD S +LCPTTKCTS+C

SSWPCVIGA--VDISANLCPTTKCTSKC

MIBiG 4.0 matches for EGW35_RS11625

31.0%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

LCPTTKCTSQC

CPTTKCTS+C

FCPTTKCTSKC

29.7%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

VDASISLCPTTKCTSQC

V S + CPTTKCTS+C

VGVSAAFCPTTKCTSRC

14.7%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

SISLC

allorf_004148_004249

Leader:

MLFPSMYISLMNIYYQ

Core:

KYQLFIFFLCTYVPSLY

Core with dehydrations:

KYQLFIFFLCysDhbYVPDhaLY

antiSMASH-DB 4.0 matches for allorf_004148_004249

100.0%

NZ_RKNR01000012.1:

Lanthipeptides: allorf_004148_004249_lanthipeptide

KYQLFIFFLCTYVPSLY

31.6%

NZ_JAHXMW010000012.1and 2 others:

NZ_JAHXMW010000012.1 Lanthipeptides: allorf_051847_052008_lanthipeptideNZ_VDYW01000008.1 Lanthipeptides: allorf_139136_139297_lanthipeptide

Lanthipeptides: allorf_051847_052008_lanthipeptide

FFLCTYVPS

FFLC+Y+ S

FFLCSYITS

Lanthipeptide(s) for EGW35_RS11610

EGW35_RS11615

Leader:

MNKRDAFETYQEKGNLKEMSPMMEEEIMDIETEIQAG

Core:

CTTNTFSLSDYLGNTGGWCTATKECMPSCN

Core with dehydrations:

CysDhbDhbNDhbFDhaLDhaDYLGNDhbGGWCysDhbADhbKECysMPDhaCysN

antiSMASH-DB 4.0 matches for EGW35_RS11615

88.2%

NZ_CP042598.1and 2 others:

NZ_RKNR01000012.1 Lanthipeptides: EGW35_RS11615_lanthipeptideNZ_RKNR01000012.1 Lanthipeptides: EGW35_RS11615_lanthipeptide

Lanthipeptides: FUT28_RS13825_lanthipeptide

CTTNTFSLSDYLGNTGGWCTATKECMPSCN

85.3%

NZ_JADPDT010000005.1and 1 other:

NZ_JADPDT010000005.1 Lanthipeptides: I4V19_RS09885_lanthipeptide

Lanthipeptides: I4V19_RS09885_lanthipeptide

CTTNTFSLSDYLGNTGGWCTATKECMPSCN

CTTNTFSLSD+LGNTGGWCTATKECMPSCN

CTTNTFSLSDFLGNTGGWCTATKECMPSCN

83.3%

NZ_BMMP01000005.1and 3 others:

NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS28370_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptideNZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptide

Lanthipeptides: IEY56_RS28370_lanthipeptide

CTTNTFSLSDYLGNTGGWCTATKECMPSCN

CTTNTFSLSD LGNTGGWCT T EC P+CN

CTTNTFSLSDVLGNTGGWCTLTVECQPNCN

with 105 more sequence matches

Only the first 10 are displayed here.

83.3%

NZ_BNBV01000031.1and 1 other:

NZ_BNBV01000031.1 Lanthipeptides: IE286_RS22995_lanthipeptide

Lanthipeptides: IE286_RS22995_lanthipeptide

CTTNTFSLSDYLGNTGGWCTATKECMPSCN

CTTNTFSLSD LGN+GGWCT TKEC P+CN

CTTNTFSLSDALGNSGGWCTLTKECQPNCN

83.3%

NZ_CP107567.1and 3 others:

NZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptideNZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptide

Lanthipeptides: OGH68_RS19760_lanthipeptide

CTTNTFSLSDYLGNTGGWCTATKECMPSCN

CTTNTFSLSD+LGN GGWCT TKEC P+CN

CTTNTFSLSDWLGNQGGWCTLTKECQPNCN

83.3%

NZ_LT985747.1and 1 other:

NZ_LT985747.1 Lanthipeptides: C8268_RS00165_lanthipeptide

Lanthipeptides: C8268_RS00165_lanthipeptide

CTTNTFSLSDYLGNTGGWCTATKECMPSCN

CTTNTF+LSDYLGN GGWCT TKEC SCN

CTTNTFTLSDYLGNKGGWCTLTKECQRSCN

80.0%

NZ_AKXV01000031.1and 4 others:

Lanthipeptides: Y19_RS0109895_lanthipeptide

CTTNTFSLSDYLGNTGGWCTATKECMPSCN

C+TNTFSLSD+LGN GGWCT TKEC P+CN

CSTNTFSLSDFLGNQGGWCTLTKECQPNCN

80.0%

NZ_BJTV01000004.1and 1 other:

NZ_BJTV01000004.1 Lanthipeptides: TNCT1_RS10200_lanthipeptide

Lanthipeptides: TNCT1_RS10200_lanthipeptide

CTTNTFSLSDYLGNTGGWCTATKECMPSCN

CTTNTFSLSD LGN GGWCT TKEC +CN

CTTNTFSLSDALGNHGGWCTLTKECQANCN

80.0%

NZ_BNCA01000011.1and 1 other:

NZ_BNCA01000011.1 Lanthipeptides: IE314_RS15865_lanthipeptide

Lanthipeptides: IE314_RS15865_lanthipeptide

CTTNTFSLSDYLGNTGGWCTATKECMPSCN

CTTNTFSLSD +GN GGWCT TKEC P+CN

CTTNTFSLSDAVGNHGGWCTLTKECQPNCN

80.0%

NZ_CP016795.1and 5 others:

Lanthipeptides: BC342_RS18360_lanthipeptide

CTTNTFSLSDYLGNTGGWCTATKECMPSC

CTTNTFSLSD LGN GGWCT TKEC P+C

CTTNTFSLSDALGNHGGWCTLTKECQPNC

80.0%

NZ_CP043317.1and 1 other:

NZ_CP043317.1 Lanthipeptides: FYC74_RS17680_lanthipeptide

Lanthipeptides: FYC74_RS17680_lanthipeptide

CTTNTFSLSDYLGNTGGWCTATKECMPSC

CTTNTFSLSD LGN GGWCT TKEC P+C

CTTNTFSLSDSLGNHGGWCTLTKECQPNC

80.0%

NZ_CP061868.1and 1 other:

NZ_CP061868.1 Lanthipeptides: IE339_RS06330_lanthipeptide

Lanthipeptides: IE339_RS06330_lanthipeptide

CTTNTFSLSDYLGNTGGWCTATKECMPSCN

CTTNTFSLSDY GN GGWCTAT ECM C

CTTNTFSLSDYWGNKGGWCTATHECMSWCK

80.0%

NZ_CP084530.1and 1 other:

NZ_CP084530.1 Lanthipeptides: LDO05_RS02075_lanthipeptide

Lanthipeptides: LDO05_RS02075_lanthipeptide

CTTNTFSLSDYLGNTGGWCTATKECMPSCN

CTTNTF+LS+YLGN GGWCT TKEC SCN

CTTNTFTLSNYLGNNGGWCTLTKECQRSCN

MIBiG 4.0 matches for EGW35_RS11615

80.0%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

CTTNTFSLSDYLGNTGGWCTATKECMPSCN

CTTNTFSLS+ LGN GGWCT TKEC P+CN

CTTNTFSLSNALGNNGGWCTLTKECQPNCN

50.0%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

FSLSDYLGNTGGWCTATKECMPSCN

+++S LGN G +CT T ECMPSCN

YNISCRLGNKGAYCTLTVECMPSCN

20.5%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

CTATKECMPSCN

CT +KEC P+CN

CTLSKECQPNCN

EGW35_RS11625

Leader:

MFTKNEKFEHNQEEESILEEISESEDTNGG

Core:

TTWACVAVSTIVDASISLCPTTKCTSQCS

Core with dehydrations:

DhbDhbWACysVAVDhaDhbIVDADhaIDhaLCysPDhbDhbKCysDhbDhaQCysDha

antiSMASH-DB 4.0 matches for EGW35_RS11625

100.0%

NZ_CP042598.1and 3 others:

NZ_CP042598.1 Lanthipeptides: FUT28_RS13815_lanthipeptideNZ_RKNR01000012.1 Lanthipeptides: EGW35_RS11625_lanthipeptideNZ_RKNR01000012.1 Lanthipeptides: EGW35_RS11625_lanthipeptide

Lanthipeptides: FUT28_RS13815_lanthipeptide

TTWACVAVSTIVDASISLCPTTKCTSQCS

89.7%

NZ_JADPDT010000005.1and 1 other:

NZ_JADPDT010000005.1 Lanthipeptides: I4V19_RS09875_lanthipeptide

Lanthipeptides: I4V19_RS09875_lanthipeptide

TTWACVAVSTIVDASISLCPTTKCTSQCS

TTWACVAVST+V+ASISLCPTTKCTS+CS

TTWACVAVSTVVEASISLCPTTKCTSKCS

69.0%

NZ_JABBGE010000004.1and 1 other:

NZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13570_lanthipeptide

Lanthipeptides: HHL19_RS13570_lanthipeptide

TTWACV---AVSTIVDASISLCPTTKCTSQC

TTW+C AV+T+V AS CPTTKCTSQC

TTWSCAVVTAVATLVSASA--CPTTKCTSQC

with 90 more sequence matches

Only the first 10 are displayed here.

69.0%

NZ_LMEI01000006.1and 1 other:

NZ_LMEI01000006.1 Lanthipeptides: ASC82_RS30550_lanthipeptide

Lanthipeptides: ASC82_RS30550_lanthipeptide

TTWACV---AVSTIVDASISLCPTTKCTSQC

TTW+C AV+T+V AS CPTTKCTSQC

TTWSCAIVTAVATLVSAS--ACPTTKCTSQC

58.6%

NZ_LT630004.1:

Lanthipeptides: BQ5796_RS18310_lanthipeptide

TTWACVAVSTIVDASISLCPTTKCTSQC

TT CV ++ V S+S+CPTTKCTSQC

TTLPCVGIT--VTISVSMCPTTKCTSQC

48.5%

NZ_QORY01000016.1and 1 other:

NZ_QORY01000016.1 Lanthipeptides: DT250_RS18265_lanthipeptide

Lanthipeptides: DT250_RS18265_lanthipeptide

TTWACVAVSTIVDASISLCPTTKCTSQC

TTW C A+ TI AS + CPTT C+S+C

TTWGC-AIFTI--ASAAQCPTTACSSKC

45.7%

NZ_CM000721.1and 9 others:

Lanthipeptides: BCERE0010_RS29355_lanthipeptide

AVSTIVDASI----SLCPTTKCTSQC

A TI+ A+I SLCPTTKCTS+C

ATPTIIGATIAVTASLCPTTKCTSRC

45.7%

NZ_CP015591.1and 15 others:

Lanthipeptides: A7A70_RS27550_lanthipeptide

AVSTIVDASI----SLCPTTKCTSQC

A TIV+A+I S+CPTTKCTS+C

ATPTIVEATIAATVSICPTTKCTSRC

45.2%

NC_018499.1and 5 others:

Lanthipeptides: BCK_RS27845_lanthipeptide

AVSTIVDASISLCPTTKCTSQC

A TIV S+ +CPTTKCTS+C

ATPTIVAVSLGICPTTKCTSKC

44.8%

NZ_BIFH01000022.1and 1 other:

NZ_BIFH01000022.1 Lanthipeptides: EMA17_RS52585_lanthipeptide

Lanthipeptides: EMA17_RS52585_lanthipeptide

TTWACVAVSTIVDASISLCPTTKCTSQC

T+ CVA T++ A+ +CPTT C+S+C

TSALCVATITLITAT--MCPTTACSSKC

43.5%

NZ_AKXV01000031.1and 1 other:

NZ_AKXV01000031.1 Lanthipeptides: Y19_RS44045_lanthipeptide

Lanthipeptides: Y19_RS44045_lanthipeptide

TTWACV---AVSTIVDASISLCPTTKCTSQC

TTW+C AV+T+V AS CPTTKCTSQC

TTWSCAIVTAVATLVSASA--CPTTKCTSQC

41.4%

NZ_LR134483.1and 1 other:

NZ_LR134483.1 Lanthipeptides: EL241_RS13590_lanthipeptide

Lanthipeptides: EL241_RS13590_lanthipeptide

VDASISLCPTTKCTSQC

V SI+LCPT KCTS+C

VPLSIALCPTAKCTSKC

41.0%

NZ_CP009280.1and 1 other:

NZ_CP009280.1 Lanthipeptides: P40081_RS37160_lanthipeptide

Lanthipeptides: P40081_RS37160_lanthipeptide

TTWACVAVSTIVDASISLCPTTKCTSQC

++W CV + VD S +LCPTTKCTS+C

SSWPCVIGA--VDISANLCPTTKCTSKC

MIBiG 4.0 matches for EGW35_RS11625

31.0%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

LCPTTKCTSQC

CPTTKCTS+C

FCPTTKCTSKC

29.7%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

VDASISLCPTTKCTSQC

V S + CPTTKCTS+C

VGVSAAFCPTTKCTSRC

14.7%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

SISLC

EGW35_RS11665

Leader:

MKKPRFKNWRSFATLALLGQTISGAIGPMIAFA

Core:

DEITHPQTVTVHCDLSHLYAVEGI

Core with dehydrations:

DEIDhbHPQDhbVDhbVHCysDLDhaHLYAVEGI

antiSMASH-DB 4.0 matches for EGW35_RS11665

100.0%

NZ_RKNR01000012.1:

Lanthipeptides: EGW35_RS11665_lanthipeptide

DEITHPQTVTVHCDLSHLYAVEGI

16.0%

NZ_QICS01000003.1:

Lanthipeptides: allorf_263557_263733_lanthipeptide

CDLSHLYAVEGI

C++ +L+A+ G+

CEVPYLFALRGV

11.8%

NC_021252.1:

Lanthipeptides: allorf_4521129_4521314_lanthipeptide

QTVTVHCDLSHLYA

+ + HC L LYA

RAIGAHCPLWTLYA

MIBiG 4.0 matches for EGW35_RS11665

14.3%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

TVTVHC

T+TV C

TLTVEC

11.8%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

QTVTVHCDL

+T T HC +

KTATCHCSI

allorf_004148_004249

Leader:

MLFPSMYISLMNIYYQ

Core:

KYQLFIFFLCTYVPSLY

Core with dehydrations:

KYQLFIFFLCysDhbYVPDhaLY

antiSMASH-DB 4.0 matches for allorf_004148_004249

100.0%

NZ_RKNR01000012.1:

Lanthipeptides: allorf_004148_004249_lanthipeptide

KYQLFIFFLCTYVPSLY

31.6%

NZ_JAHXMW010000012.1and 2 others:

NZ_JAHXMW010000012.1 Lanthipeptides: allorf_051847_052008_lanthipeptideNZ_VDYW01000008.1 Lanthipeptides: allorf_139136_139297_lanthipeptide

Lanthipeptides: allorf_051847_052008_lanthipeptide

FFLCTYVPS

FFLC+Y+ S

FFLCSYITS

allorf_023523_023696

Leader:

MTISVVKIGQNLVVSLTA

Core:

NLIRKIPKHLPNLATFEPELLKRLTFFKKDKTCTFLLKS

Core with dehydrations:

NLIRKIPKHLPNLADhbFEPELLKRLDhbFFKKDKDhbCysDhbFLLKDha

antiSMASH-DB 4.0 matches for allorf_023523_023696

100.0%

NZ_RKNR01000012.1:

Lanthipeptides: allorf_023523_023696_lanthipeptide

NLIRKIPKHLPNLATFEPELLKRLTFFKKDKTCTFLLKS

30.8%

NZ_CP095740.1:

Lanthipeptides: allorf_1761125_1761268_lanthipeptide

RKIPKH----LPNLATFEPELLKRLTFFKKDKTCTF

R +P H L + F P LL+RL ++ TF

RALPGHRFVGLSPMHRFLPNLLRRLKSISCPRSMTF

17.5%

NZ_JANHJQ010000013.1:

Lanthipeptides: allorf_146838_147023_lanthipeptide

LTFFKKDKTCTFLLK

+TF K TC FL++

VTFVAKQGTCAFLMQ

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.33 out of 27.78

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.54 out of 26.06

Confidence: medium

Additional weak hits (3):

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.50 out of 39.62

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 24.11 out of 35.63

Confidence: weak

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 20.22 out of 27.18

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

EGW35_RS11615 - Class II

Cleavage pHMM score: -4.70

RODEO score: 0

Monoisotopic mass: 3042.3 Da

Molecular weight: 3044.4 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3062.4 Da N = 1; 3080.4 Da N = 2; 3098.4 Da N = 3; 3116.4 Da N = 4; 3134.5 Da N = 5

EGW35_RS11625 - Class II

Cleavage pHMM score: -1.20

RODEO score: 0

Monoisotopic mass: 2777.4 Da

Molecular weight: 2779.2 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 2797.2 Da N = 1; 2815.2 Da N = 2; 2833.3 Da N = 3; 2851.3 Da N = 4; 2869.3 Da N = 5; 2887.3 Da N = 6; 2905.3 Da N = 7

EGW35_RS11665 - Class II

Cleavage pHMM score: -4.80

RODEO score: 0

Monoisotopic mass: 2604.3 Da

Molecular weight: 2605.9 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2623.9 Da N = 1; 2641.9 Da N = 2; 2659.9 Da N = 3

allorf_004148_004249 - Class II

Cleavage pHMM score: -7.10

RODEO score: 0

Monoisotopic mass: 2108.1 Da

Molecular weight: 2109.5 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2127.5 Da N = 1

allorf_023523_023696 - Class II

Cleavage pHMM score: -6.30

RODEO score: 0

Monoisotopic mass: 4550.7 Da

Molecular weight: 4553.5 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 4571.5 Da N = 1; 4589.5 Da N = 2; 4607.5 Da N = 3; 4625.6 Da N = 4

EGW35_RS11615 - Class II

Cleavage pHMM score: -4.70

RODEO score: 0

Monoisotopic mass: 3042.3 Da

Molecular weight: 3044.4 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3062.4 Da N = 1; 3080.4 Da N = 2; 3098.4 Da N = 3; 3116.4 Da N = 4; 3134.5 Da N = 5

EGW35_RS11625 - Class II

Cleavage pHMM score: -1.20

RODEO score: 0

Monoisotopic mass: 2777.4 Da

Molecular weight: 2779.2 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 2797.2 Da N = 1; 2815.2 Da N = 2; 2833.3 Da N = 3; 2851.3 Da N = 4; 2869.3 Da N = 5; 2887.3 Da N = 6; 2905.3 Da N = 7

allorf_004148_004249 - Class II

Cleavage pHMM score: -7.10

RODEO score: 0

Monoisotopic mass: 2108.1 Da

Molecular weight: 2109.5 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2127.5 Da N = 1

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MogR	Repressor of flagellar motility genes

NZ_RKNR01000001.1 - Region 1 - terpene-precursor

Download region GenBank file

Download region SVG

Location: 117,430 - 138,314 nt. (total: 20,885 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: peptidase

EGW35_RS00650: methionine aminopeptidase

smcogs: SMCOG1172: methionine aminopeptidase

Ligases: synthetase

EGW35_RS00620: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000639.3	0.34	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.34	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0001605.3	0.32	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0000633.3	0.31	terpene	carotenoid	Streptomyces avermitilis
BGC0001227.3	0.31	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000648.3	0.31	terpene	carotenoid	Myxococcus xanthus
BGC0002181.3	0.31	terpene	pleuromutilin	Rhodocybe pseudopiperita

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000639.3	0.34	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.34	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0001605.3	0.32	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0000633.3	0.31	terpene	carotenoid	Streptomyces avermitilis
BGC0001227.3	0.31	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000648.3	0.31	terpene	carotenoid	Myxococcus xanthus
BGC0002181.3	0.31	terpene	pleuromutilin	Rhodocybe pseudopiperita

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

EGW35_RS00620: PT_FPPS_like

Domain 1 (30 - 278): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: IPP, DMAPP → FPP

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.69 out of 27.78

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.51 out of 27.78

Confidence: strong

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.31 out of 18.46

Confidence: strong

Additional weak hits (1):

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.88 out of 30.98

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
RpoN	Regulator of nitrogen assimilation and virulence

NZ_RKNR01000002.1 - Region 1 - T3PKS

Download region GenBank file

Download region SVG

Location: 320,563 - 359,668 nt. (total: 39,106 nt) Show pHMM detection rules used

Region on contig edge.

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase reductase

EGW35_RS03320: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

EGW35_RS03340: hydroxymethylglutaryl-CoA reductase

smcogs: SMCOG1187: hydroxymethylglutaryl-CoA reductase

Hydrolases: back translocase hydrolase

EGW35_RS03255: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

EGW35_RS03275: GTP-binding protein LepA

smcogs: SMCOG1190: GTP-binding protein LepA

Ligases: synthase

EGW35_RS03345: hydroxymethylglutaryl-CoA synthase

smcogs: SMCOG1043: hydroxymethylglutaryl-CoA synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000866.5	0.51	other (other)	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0000867.3	0.49	other (other)	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0000255.5	0.42	PKS	pederin	Uncultured bacterium
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000616.4	0.40	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0002561.3	0.40	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0001639.3	0.40	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0000486.4	0.40	ribosomal	butyrivibriocin AR10	Butyrivibrio fibrisolvens
BGC0002707.2	0.39	terpene	(+)-δ-cadinol	Coniophora puteana RWD-64-598 SS2
BGC0001887.3	0.38	ribosomal	huazacin	Bacillus thuringiensis serovar huazhongensis BGSC 4BD1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000866.5	0.51	other (other)	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0000867.3	0.49	other (other)	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0000255.5	0.42	PKS	pederin	Uncultured bacterium
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000616.4	0.40	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0002561.3	0.40	other (other)	phenazine SA, phenazine SB, phenazine SC	Streptomyces sp.
BGC0001639.3	0.40	ribosomal	klebsidin	Klebsiella pneumoniae
BGC0000486.4	0.40	ribosomal	butyrivibriocin AR10	Butyrivibrio fibrisolvens
BGC0002707.2	0.39	terpene	(+)-δ-cadinol	Coniophora puteana RWD-64-598 SS2
BGC0001887.3	0.38	ribosomal	huazacin	Bacillus thuringiensis serovar huazhongensis BGSC 4BD1

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.54 out of 23.79

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.18 out of 20.97

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.37 out of 26.06

Confidence: medium

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.52 out of 25.88

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.02 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.64 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.42 out of 27.78

Confidence: medium

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.39 out of 25.88

Confidence: medium

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.27 out of 26.85

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.75 out of 28.19

Confidence: medium

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.07 out of 32.93

Confidence: medium

Additional weak hits (5):

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 19.95 out of 25.88

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.68 out of 32.74

Confidence: weak

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 22.55 out of 29.51

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 26.22 out of 33.14

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 26.23 out of 33.14

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
IolR	Regulator of the inositol catabolism
LexA variant 3	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
PsrA	Oleic acid responsive regulator
RutR	Regulator of the pyrimidine and purine metabolism
ZuR variant 1	Zinc-responsive repressor

NZ_RKNR01000007.1 - Region 1 - terpene

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Location: 77,036 - 97,926 nt. (total: 20,891 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

EGW35_RS08475: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

Transferases: kinase

EGW35_RS08500: glycerol kinase

smcogs: SMCOG1210: glycerol kinase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000647.3	0.58	terpene	carotenoid	Rhodobacter sphaeroides
BGC0001456.3	0.49	terpene	isorenieratene	Streptomyces argillaceus
BGC0000664.5	0.49	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000646.5	0.49	terpene	β-carotein	uncultured bacterium
BGC0000645.3	0.47	terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0000656.5	0.47	terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0000639.3	0.47	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000640.3	0.47	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0000641.3	0.47	terpene	carotenoid	Enterobacteriaceae bacterium DC416
BGC0000633.3	0.46	terpene	carotenoid	Streptomyces avermitilis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000647.3	0.58	terpene	carotenoid	Rhodobacter sphaeroides
BGC0001456.3	0.49	terpene	isorenieratene	Streptomyces argillaceus
BGC0000664.5	0.49	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0000646.5	0.49	terpene	β-carotein	uncultured bacterium
BGC0000645.3	0.47	terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0000656.5	0.47	terpene	zeaxanthin	Xanthobacter autotrophicus Py2
BGC0000639.3	0.47	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000640.3	0.47	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0000641.3	0.47	terpene	carotenoid	Enterobacteriaceae bacterium DC416
BGC0000633.3	0.46	terpene	carotenoid	Streptomyces avermitilis

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	C30 carotenoid	diapophytoene	C30	acyclic	none

Genes with terpene domains:

EGW35_RS08470: PT_phytoene_like

Domain 1 (14 - 284): Prenyltransferase; Phytoene synthase like

Subtype: Diapophytoene synthase

Reactions:: FPP → diapophytoene

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.82 out of 18.46

Confidence: medium

Additional weak hits (3):

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.21 out of 27.04

Confidence: weak

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 19.86 out of 29.51

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.33 out of 31.73

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate

TFBS definitions

Regulator	Description
RpoN	Regulator of nitrogen assimilation and virulence

NZ_RKNR01000009.1 - Region 1 - cyclic-lactone-autoinducer

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Location: 1 - 16,627 nt. (total: 16,627 nt) Show pHMM detection rules used

Region on contig edge.

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001291.3	0.41	ribosomal	enterocin NKR-5-3B	Enterococcus faecium
BGC0000494.5	0.40	ribosomal	uberolysin	Streptococcus uberis
BGC0000540.5	0.32	ribosomal	paenibacillin	Paenibacillus polymyxa OSY-DF
BGC0002579.2	0.31	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0000624.3	0.31	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0002667.2	0.27	ribosomal	estericin A	Clostridium estertheticum
BGC0002360.3	0.18	NRPS	depsibosamycin B, depsibosamycin C, depsibosamycin D	Streptomyces aurantiacus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001291.3	0.41	ribosomal	enterocin NKR-5-3B	Enterococcus faecium
BGC0000494.5	0.40	ribosomal	uberolysin	Streptococcus uberis
BGC0000540.5	0.32	ribosomal	paenibacillin	Paenibacillus polymyxa OSY-DF
BGC0002579.2	0.31	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0000624.3	0.31	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0002667.2	0.27	ribosomal	estericin A	Clostridium estertheticum
BGC0002360.3	0.18	NRPS	depsibosamycin B, depsibosamycin C, depsibosamycin D	Streptomyces aurantiacus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.21 out of 26.06

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.23 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.78 out of 27.78

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.71 out of 20.97

Confidence: medium

Additional weak hits (2):

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.76 out of 27.55

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 24.41 out of 30.97

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis