Select genomic region:
Overview
3.1
11.1
21.1
26.1
28.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_RKNR01000012.1 (Enterococcus durans)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 3.1 | lanthipeptide-class-ii,cyclic-lactone-autoinducer | 1 | 30,563 | Low | thusin | ribosomal:RiPP

NZ_RKNR01000001.1 (Enterococcus durans)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 11.1 | terpene-precursor | 117,430 | 138,314 |

NZ_RKNR01000002.1 (Enterococcus durans)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 21.1 | T3PKS | 320,563 | 359,668 |

NZ_RKNR01000007.1 (Enterococcus durans)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 26.1 | terpene | 77,036 | 97,926 |

NZ_RKNR01000009.1 (Enterococcus durans)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 28.1 | cyclic-lactone-autoinducer | 1 | 16,627 |

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 3.1 | lanthipeptide-class-ii,cyclic-lactone-autoinducer | 1 | 30,563 | Low | thusin | ribosomal:RiPP
Region 11.1 | terpene-precursor | 117,430 | 138,314 |
Region 21.1 | T3PKS | 320,563 | 359,668 |
Region 26.1 | terpene | 77,036 | 97,926 |
Region 28.1 | cyclic-lactone-autoinducer | 1 | 16,627 |

No secondary metabolite regions were found in these records:
  NZ_RKNR01000010.1 (Enterococcus durans)
  NZ_RKNR01000011.1 (Enterococcus durans)
  NZ_RKNR01000013.1 (Enterococcus durans)
  NZ_RKNR01000014.1 (Enterococcus durans)
  NZ_RKNR01000015.1 (Enterococcus durans)
  NZ_RKNR01000016.1 (Enterococcus durans)
  NZ_RKNR01000017.1 (Enterococcus durans)
  NZ_RKNR01000018.1 (Enterococcus durans)
  NZ_RKNR01000019.1 (Enterococcus durans)
  NZ_RKNR01000020.1 (Enterococcus durans)
  NZ_RKNR01000021.1 (Enterococcus durans)
  NZ_RKNR01000022.1 (Enterococcus durans)
  NZ_RKNR01000023.1 (Enterococcus durans)
  NZ_RKNR01000024.1 (Enterococcus durans)
  NZ_RKNR01000025.1 (Enterococcus durans)
  NZ_RKNR01000026.1 (Enterococcus durans)
  NZ_RKNR01000027.1 (Enterococcus durans)
  NZ_RKNR01000028.1 (Enterococcus durans)
  NZ_RKNR01000003.1 (Enterococcus durans)
  NZ_RKNR01000004.1 (Enterococcus durans)
  NZ_RKNR01000005.1 (Enterococcus durans)
  NZ_RKNR01000006.1 (Enterococcus durans)
  NZ_RKNR01000008.1 (Enterococcus durans)

Compact view
NZ_RKNR01000012.1 - Region 1 - cyclic-lactone-autoinducer,lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 30,563 nt. (total: 30,563 nt) Show pHMM detection rules used
Region on contig edge.
lanthipeptide-class-ii: cds(LANC_like and DUF4135)
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
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Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: cyclase
EGW35_RS11590: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

EGW35_RS11610: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000623.3 |  |  | 0.44 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000525.5 |  |  | 0.42 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0002110.3 |  |  | 0.41 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0000520.5 |  |  | 0.41 | ribosomal | lacticin 3147 A1, lacticin 3147 A2 | Lactococcus lactis
BGC0000539.5 |  |  | 0.40 | ribosomal | nukacin ISK-1 | Staphylococcus warneri
BGC0000555.3 |  |  | 0.39 | ribosomal | staphylococcin C55 α, staphylococcin C55 β | Staphylococcus aureus
BGC0001391.3 |  |  | 0.39 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni
BGC0000500.5 |  |  | 0.39 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0001311.5 |  |  | 0.37 | ribosomal | flavecins | Ruminococcus flavefaciens FD-1
BGC0001229.4 |  |  | 0.37 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002110.3 |  | 0.56 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0000623.3 |  | 0.55 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0000626.3 |  | 0.55 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000500.5 |  | 0.55 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000555.3 |  | 0.55 | ribosomal | staphylococcin C55 α, staphylococcin C55 β | Staphylococcus aureus
BGC0000552.3 |  | 0.55 | ribosomal | SmbA, SmbB | Streptococcus mutans
BGC0000520.5 |  | 0.55 | ribosomal | lacticin 3147 A1, lacticin 3147 A2 | Lactococcus lactis
BGC0001311.5 |  | 0.54 | ribosomal | flavecins | Ruminococcus flavefaciens FD-1
BGC0000539.5 |  | 0.54 | ribosomal | nukacin ISK-1 | Staphylococcus warneri
BGC0000525.5 |  | 0.53 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for EGW35_RS11590

EGW35_RS11615
Leader:
MNKRDAFETYQEKGNLKEMSPMMEEEIMDIETEIQAG
Core:
C T T N T F S L S D Y L G N T G G W C T A T K E C M P S C N
Core with dehydrations:
Cys Dhb Dhb N Dhb F Dha L Dha D Y L G N Dhb G G W Cys Dhb A Dhb K E Cys M P Dha Cys N

#### antiSMASH-DB 4.0 matches for EGW35_RS11615

88.2%
NZ_CP042598.1 and 2 others:
NZ_RKNR01000012.1 Lanthipeptides: EGW35_RS11615_lanthipeptide NZ_RKNR01000012.1 Lanthipeptides: EGW35_RS11615_lanthipeptide
Lanthipeptides: FUT28_RS13825_lanthipeptide
1
C T T N T F S L S D Y L G N T G G W C T A T K E C M P S C N
30
C T T N T F S L S D Y L G N T G G W C T A T K E C M P S C N
5
C T T N T F S L S D Y L G N T G G W C T A T K E C M P S C N
34
85.3%
NZ_JADPDT010000005.1 and 1 other:
NZ_JADPDT010000005.1 Lanthipeptides: I4V19_RS09885_lanthipeptide
Lanthipeptides: I4V19_RS09885_lanthipeptide
1
C T T N T F S L S D Y L G N T G G W C T A T K E C M P S C N
30
C T T N T F S L S D+L G N T G G W C T A T K E C M P S C N
5
C T T N T F S L S D F L G N T G G W C T A T K E C M P S C N
34
83.3%
NZ_BMMP01000005.1 and 3 others:
NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS28370_lanthipeptide NZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptide NZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptide
Lanthipeptides: IEY56_RS28370_lanthipeptide
1
C T T N T F S L S D Y L G N T G G W C T A T K E C M P S C N
30
C T T N T F S L S D L G N T G G W C T T E C P+C N
1
C T T N T F S L S D V L G N T G G W C T L T V E C Q P N C N
30
with 105 more sequence matches
Only the first 10 are displayed here.
83.3%
NZ_BNBV01000031.1 and 1 other:
NZ_BNBV01000031.1 Lanthipeptides: IE286_RS22995_lanthipeptide
Lanthipeptides: IE286_RS22995_lanthipeptide
1
C T T N T F S L S D Y L G N T G G W C T A T K E C M P S C N
30
C T T N T F S L S D L G N+G G W C T T K E C P+C N
1
C T T N T F S L S D A L G N S G G W C T L T K E C Q P N C N
30
83.3%
NZ_CP107567.1 and 3 others:
NZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptide NZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptide NZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptide
Lanthipeptides: OGH68_RS19760_lanthipeptide
1
C T T N T F S L S D Y L G N T G G W C T A T K E C M P S C N
30
C T T N T F S L S D+L G N G G W C T T K E C P+C N
1
C T T N T F S L S D W L G N Q G G W C T L T K E C Q P N C N
30
83.3%
NZ_LT985747.1 and 1 other:
NZ_LT985747.1 Lanthipeptides: C8268_RS00165_lanthipeptide
Lanthipeptides: C8268_RS00165_lanthipeptide
1
C T T N T F S L S D Y L G N T G G W C T A T K E C M P S C N
30
C T T N T F+L S D Y L G N G G W C T T K E C S C N
1
C T T N T F T L S D Y L G N K G G W C T L T K E C Q R S C N
30
80.0%
NZ_AKXV01000031.1 and 4 others:
NZ_AKXV01000031.1 Lanthipeptides: Y19_RS0109895_lanthipeptide NZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13545_lanthipeptide NZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide NZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide
Lanthipeptides: Y19_RS0109895_lanthipeptide
1
C T T N T F S L S D Y L G N T G G W C T A T K E C M P S C N
30
C+T N T F S L S D+L G N G G W C T T K E C P+C N
1
C S T N T F S L S D F L G N Q G G W C T L T K E C Q P N C N
30
80.0%
NZ_BJTV01000004.1 and 1 other:
NZ_BJTV01000004.1 Lanthipeptides: TNCT1_RS10200_lanthipeptide
Lanthipeptides: TNCT1_RS10200_lanthipeptide
1
C T T N T F S L S D Y L G N T G G W C T A T K E C M P S C N
30
C T T N T F S L S D L G N G G W C T T K E C +C N
1
C T T N T F S L S D A L G N H G G W C T L T K E C Q A N C N
30
80.0%
NZ_BNCA01000011.1 and 1 other:
NZ_BNCA01000011.1 Lanthipeptides: IE314_RS15865_lanthipeptide
Lanthipeptides: IE314_RS15865_lanthipeptide
1
C T T N T F S L S D Y L G N T G G W C T A T K E C M P S C N
30
C T T N T F S L S D +G N G G W C T T K E C P+C N
1
C T T N T F S L S D A V G N H G G W C T L T K E C Q P N C N
30
80.0%
NZ_CP016795.1 and 5 others:
NZ_CP016795.1 Lanthipeptides: BC342_RS18360_lanthipeptide NZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptide NZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptide NZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptide NZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptide
Lanthipeptides: BC342_RS18360_lanthipeptide
1
C T T N T F S L S D Y L G N T G G W C T A T K E C M P S C
29
C T T N T F S L S D L G N G G W C T T K E C P+C
1
C T T N T F S L S D A L G N H G G W C T L T K E C Q P N C
29
80.0%
NZ_CP043317.1 and 1 other:
NZ_CP043317.1 Lanthipeptides: FYC74_RS17680_lanthipeptide
Lanthipeptides: FYC74_RS17680_lanthipeptide
1
C T T N T F S L S D Y L G N T G G W C T A T K E C M P S C
29
C T T N T F S L S D L G N G G W C T T K E C P+C
1
C T T N T F S L S D S L G N H G G W C T L T K E C Q P N C
29
80.0%
NZ_CP061868.1 and 1 other:
NZ_CP061868.1 Lanthipeptides: IE339_RS06330_lanthipeptide
Lanthipeptides: IE339_RS06330_lanthipeptide
1
C T T N T F S L S D Y L G N T G G W C T A T K E C M P S C N
30
C T T N T F S L S D Y G N G G W C T A T E C M C
1
C T T N T F S L S D Y W G N K G G W C T A T H E C M S W C K
30
80.0%
NZ_CP084530.1 and 1 other:
NZ_CP084530.1 Lanthipeptides: LDO05_RS02075_lanthipeptide
Lanthipeptides: LDO05_RS02075_lanthipeptide
1
C T T N T F S L S D Y L G N T G G W C T A T K E C M P S C N
30
C T T N T F+L S+Y L G N G G W C T T K E C S C N
1
C T T N T F T L S N Y L G N N G G W C T L T K E C Q R S C N
30

#### MIBiG 4.0 matches for EGW35_RS11615

80.0%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
1
C T T N T F S L S D Y L G N T G G W C T A T K E C M P S C N
30
C T T N T F S L S+ L G N G G W C T T K E C P+C N
1
C T T N T F S L S N A L G N N G G W C T L T K E C Q P N C N
30
50.0%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
6
F S L S D Y L G N T G G W C T A T K E C M P S C N
30
+++S L G N G +C T T E C M P S C N
4
Y N I S C R L G N K G A Y C T L T V E C M P S C N
28
20.5%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
19
C T A T K E C M P S C N
30
C T +K E C P+C N
28
C T L S K E C Q P N C N
39
EGW35_RS11625
Leader:
MFTKNEKFEHNQEEESILEEISESEDTNGG
Core:
T T W A C V A V S T I V D A S I S L C P T T K C T S Q C S
Core with dehydrations:
Dhb Dhb W A Cys V A V Dha Dhb I V D A Dha I Dha L Cys P Dhb Dhb K Cys Dhb Dha Q Cys Dha

#### antiSMASH-DB 4.0 matches for EGW35_RS11625

100.0%
NZ_CP042598.1 and 3 others:
NZ_CP042598.1 Lanthipeptides: FUT28_RS13815_lanthipeptide NZ_RKNR01000012.1 Lanthipeptides: EGW35_RS11625_lanthipeptide NZ_RKNR01000012.1 Lanthipeptides: EGW35_RS11625_lanthipeptide
Lanthipeptides: FUT28_RS13815_lanthipeptide
1
T T W A C V A V S T I V D A S I S L C P T T K C T S Q C S
29
T T W A C V A V S T I V D A S I S L C P T T K C T S Q C S
1
T T W A C V A V S T I V D A S I S L C P T T K C T S Q C S
29
89.7%
NZ_JADPDT010000005.1 and 1 other:
NZ_JADPDT010000005.1 Lanthipeptides: I4V19_RS09875_lanthipeptide
Lanthipeptides: I4V19_RS09875_lanthipeptide
1
T T W A C V A V S T I V D A S I S L C P T T K C T S Q C S
29
T T W A C V A V S T+V+A S I S L C P T T K C T S+C S
1
T T W A C V A V S T V V E A S I S L C P T T K C T S K C S
29
69.0%
NZ_JABBGE010000004.1 and 1 other:
NZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13570_lanthipeptide
Lanthipeptides: HHL19_RS13570_lanthipeptide
1
T T W A C V---A V S T I V D A S I S L C P T T K C T S Q C
28
T T W+C A V+T+V A S C P T T K C T S Q C
1
T T W S C A V V T A V A T L V S A S A--C P T T K C T S Q C
29
with 90 more sequence matches
Only the first 10 are displayed here.
69.0%
NZ_LMEI01000006.1 and 1 other:
NZ_LMEI01000006.1 Lanthipeptides: ASC82_RS30550_lanthipeptide
Lanthipeptides: ASC82_RS30550_lanthipeptide
1
T T W A C V---A V S T I V D A S I S L C P T T K C T S Q C
28
T T W+C A V+T+V A S C P T T K C T S Q C
1
T T W S C A I V T A V A T L V S A S--A C P T T K C T S Q C
29
58.6%
NZ_LT630004.1:
Lanthipeptides: BQ5796_RS18310_lanthipeptide
1
T T W A C V A V S T I V D A S I S L C P T T K C T S Q C
28
T T C V ++ V S+S+C P T T K C T S Q C
2
T T L P C V G I T--V T I S V S M C P T T K C T S Q C
27
48.5%
NZ_QORY01000016.1 and 1 other:
NZ_QORY01000016.1 Lanthipeptides: DT250_RS18265_lanthipeptide
Lanthipeptides: DT250_RS18265_lanthipeptide
1
T T W A C V A V S T I V D A S I S L C P T T K C T S Q C
28
T T W C A+ T I A S + C P T T C+S+C
8
T T W G C-A I F T I--A S A A Q C P T T A C S S K C
32
45.7%
NZ_CM000721.1 and 9 others:
NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptide NZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide
Lanthipeptides: BCERE0010_RS29355_lanthipeptide
7
A V S T I V D A S I----S L C P T T K C T S Q C
28
A T I+ A+I S L C P T T K C T S+C
10
A T P T I I G A T I A V T A S L C P T T K C T S R C
35
45.7%
NZ_CP015591.1 and 15 others:
NZ_CP078085.1 Lanthipeptides: KU891_RS29355_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29350_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29345_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29340_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29335_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptide
Lanthipeptides: A7A70_RS27550_lanthipeptide
7
A V S T I V D A S I----S L C P T T K C T S Q C
28
A T I V+A+I S+C P T T K C T S+C
10
A T P T I V E A T I A A T V S I C P T T K C T S R C
35
45.2%
NC_018499.1 and 5 others:
NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27845_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide
Lanthipeptides: BCK_RS27845_lanthipeptide
7
A V S T I V D A S I S L C P T T K C T S Q C
28
A T I V S+ +C P T T K C T S+C
10
A T P T I V A V S L G I C P T T K C T S K C
31
44.8%
NZ_BIFH01000022.1 and 1 other:
NZ_BIFH01000022.1 Lanthipeptides: EMA17_RS52585_lanthipeptide
Lanthipeptides: EMA17_RS52585_lanthipeptide
1
T T W A C V A V S T I V D A S I S L C P T T K C T S Q C
28
T+ C V A T++ A+ +C P T T C+S+C
3
T S A L C V A T I T L I T A T--M C P T T A C S S K C
28
43.5%
NZ_AKXV01000031.1 and 1 other:
NZ_AKXV01000031.1 Lanthipeptides: Y19_RS44045_lanthipeptide
Lanthipeptides: Y19_RS44045_lanthipeptide
1
T T W A C V---A V S T I V D A S I S L C P T T K C T S Q C
28
T T W+C A V+T+V A S C P T T K C T S Q C
18
T T W S C A I V T A V A T L V S A S A--C P T T K C T S Q C
46
41.4%
NZ_LR134483.1 and 1 other:
NZ_LR134483.1 Lanthipeptides: EL241_RS13590_lanthipeptide
Lanthipeptides: EL241_RS13590_lanthipeptide
12
V D A S I S L C P T T K C T S Q C
28
V S I+L C P T K C T S+C
7
V P L S I A L C P T A K C T S K C
23
41.0%
NZ_CP009280.1 and 1 other:
NZ_CP009280.1 Lanthipeptides: P40081_RS37160_lanthipeptide
Lanthipeptides: P40081_RS37160_lanthipeptide
1
T T W A C V A V S T I V D A S I S L C P T T K C T S Q C
28
++W C V + V D S +L C P T T K C T S+C
14
S S W P C V I G A--V D I S A N L C P T T K C T S K C
39

#### MIBiG 4.0 matches for EGW35_RS11625

31.0%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
18
L C P T T K C T S Q C
28
C P T T K C T S+C
16
F C P T T K C T S K C
26
29.7%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
12
V D A S I S L C P T T K C T S Q C
28
V S + C P T T K C T S+C
21
V G V S A A F C P T T K C T S R C
37
14.7%
BGC0000535.4 (ADJ56352.1):
Lanthipeptide: nisin A
15
S I S L C
19
S I S L C
3
S I S L C
7
allorf_004148_004249
Leader:
MLFPSMYISLMNIYYQ
Core:
K Y Q L F I F F L C T Y V P S L Y
Core with dehydrations:
K Y Q L F I F F L Cys Dhb Y V P Dha L Y

#### antiSMASH-DB 4.0 matches for allorf_004148_004249

100.0%
NZ_RKNR01000012.1:
Lanthipeptides: allorf_004148_004249_lanthipeptide
1
K Y Q L F I F F L C T Y V P S L Y
17
K Y Q L F I F F L C T Y V P S L Y
1
K Y Q L F I F F L C T Y V P S L Y
17
31.6%
NZ_JAHXMW010000012.1 and 2 others:
NZ_JAHXMW010000012.1 Lanthipeptides: allorf_051847_052008_lanthipeptide NZ_VDYW01000008.1 Lanthipeptides: allorf_139136_139297_lanthipeptide
Lanthipeptides: allorf_051847_052008_lanthipeptide
7
F F L C T Y V P S
15
F F L C+Y+ S
1
F F L C S Y I T S
9

#### Lanthipeptide(s) for EGW35_RS11610

EGW35_RS11615
Leader:
MNKRDAFETYQEKGNLKEMSPMMEEEIMDIETEIQAG
Core:
C T T N T F S L S D Y L G N T G G W C T A T K E C M P S C N
Core with dehydrations:
Cys Dhb Dhb N Dhb F Dha L Dha D Y L G N Dhb G G W Cys Dhb A Dhb K E Cys M P Dha Cys N

#### antiSMASH-DB 4.0 matches for EGW35_RS11615

88.2%
NZ_CP042598.1 and 2 others:
NZ_RKNR01000012.1 Lanthipeptides: EGW35_RS11615_lanthipeptide NZ_RKNR01000012.1 Lanthipeptides: EGW35_RS11615_lanthipeptide
Lanthipeptides: FUT28_RS13825_lanthipeptide
1
C T T N T F S L S D Y L G N T G G W C T A T K E C M P S C N
30
C T T N T F S L S D Y L G N T G G W C T A T K E C M P S C N
5
C T T N T F S L S D Y L G N T G G W C T A T K E C M P S C N
34
85.3%
NZ_JADPDT010000005.1 and 1 other:
NZ_JADPDT010000005.1 Lanthipeptides: I4V19_RS09885_lanthipeptide
Lanthipeptides: I4V19_RS09885_lanthipeptide
1
C T T N T F S L S D Y L G N T G G W C T A T K E C M P S C N
30
C T T N T F S L S D+L G N T G G W C T A T K E C M P S C N
5
C T T N T F S L S D F L G N T G G W C T A T K E C M P S C N
34
83.3%
NZ_BMMP01000005.1 and 3 others:
NZ_BMMP01000005.1 Lanthipeptides: IEY56_RS28370_lanthipeptide NZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptide NZ_FMHJ01000003.1 Lanthipeptides: H181DRAFT_RS07545_lanthipeptide
Lanthipeptides: IEY56_RS28370_lanthipeptide
1
C T T N T F S L S D Y L G N T G G W C T A T K E C M P S C N
30
C T T N T F S L S D L G N T G G W C T T E C P+C N
1
C T T N T F S L S D V L G N T G G W C T L T V E C Q P N C N
30
with 105 more sequence matches
Only the first 10 are displayed here.
83.3%
NZ_BNBV01000031.1 and 1 other:
NZ_BNBV01000031.1 Lanthipeptides: IE286_RS22995_lanthipeptide
Lanthipeptides: IE286_RS22995_lanthipeptide
1
C T T N T F S L S D Y L G N T G G W C T A T K E C M P S C N
30
C T T N T F S L S D L G N+G G W C T T K E C P+C N
1
C T T N T F S L S D A L G N S G G W C T L T K E C Q P N C N
30
83.3%
NZ_CP107567.1 and 3 others:
NZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptide NZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptide NZ_CP107567.1 Lanthipeptides: OGH68_RS19760_lanthipeptide
Lanthipeptides: OGH68_RS19760_lanthipeptide
1
C T T N T F S L S D Y L G N T G G W C T A T K E C M P S C N
30
C T T N T F S L S D+L G N G G W C T T K E C P+C N
1
C T T N T F S L S D W L G N Q G G W C T L T K E C Q P N C N
30
83.3%
NZ_LT985747.1 and 1 other:
NZ_LT985747.1 Lanthipeptides: C8268_RS00165_lanthipeptide
Lanthipeptides: C8268_RS00165_lanthipeptide
1
C T T N T F S L S D Y L G N T G G W C T A T K E C M P S C N
30
C T T N T F+L S D Y L G N G G W C T T K E C S C N
1
C T T N T F T L S D Y L G N K G G W C T L T K E C Q R S C N
30
80.0%
NZ_AKXV01000031.1 and 4 others:
NZ_AKXV01000031.1 Lanthipeptides: Y19_RS0109895_lanthipeptide NZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13545_lanthipeptide NZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide NZ_LMEI01000006.1 Lanthipeptides: ASC82_RS06140_lanthipeptide
Lanthipeptides: Y19_RS0109895_lanthipeptide
1
C T T N T F S L S D Y L G N T G G W C T A T K E C M P S C N
30
C+T N T F S L S D+L G N G G W C T T K E C P+C N
1
C S T N T F S L S D F L G N Q G G W C T L T K E C Q P N C N
30
80.0%
NZ_BJTV01000004.1 and 1 other:
NZ_BJTV01000004.1 Lanthipeptides: TNCT1_RS10200_lanthipeptide
Lanthipeptides: TNCT1_RS10200_lanthipeptide
1
C T T N T F S L S D Y L G N T G G W C T A T K E C M P S C N
30
C T T N T F S L S D L G N G G W C T T K E C +C N
1
C T T N T F S L S D A L G N H G G W C T L T K E C Q A N C N
30
80.0%
NZ_BNCA01000011.1 and 1 other:
NZ_BNCA01000011.1 Lanthipeptides: IE314_RS15865_lanthipeptide
Lanthipeptides: IE314_RS15865_lanthipeptide
1
C T T N T F S L S D Y L G N T G G W C T A T K E C M P S C N
30
C T T N T F S L S D +G N G G W C T T K E C P+C N
1
C T T N T F S L S D A V G N H G G W C T L T K E C Q P N C N
30
80.0%
NZ_CP016795.1 and 5 others:
NZ_CP016795.1 Lanthipeptides: BC342_RS18360_lanthipeptide NZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptide NZ_CP036534.1 Lanthipeptides: EZV63_RS18960_lanthipeptide NZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptide NZ_CP094676.1 Lanthipeptides: L6J92_RS01495_lanthipeptide
Lanthipeptides: BC342_RS18360_lanthipeptide
1
C T T N T F S L S D Y L G N T G G W C T A T K E C M P S C
29
C T T N T F S L S D L G N G G W C T T K E C P+C
1
C T T N T F S L S D A L G N H G G W C T L T K E C Q P N C
29
80.0%
NZ_CP043317.1 and 1 other:
NZ_CP043317.1 Lanthipeptides: FYC74_RS17680_lanthipeptide
Lanthipeptides: FYC74_RS17680_lanthipeptide
1
C T T N T F S L S D Y L G N T G G W C T A T K E C M P S C
29
C T T N T F S L S D L G N G G W C T T K E C P+C
1
C T T N T F S L S D S L G N H G G W C T L T K E C Q P N C
29
80.0%
NZ_CP061868.1 and 1 other:
NZ_CP061868.1 Lanthipeptides: IE339_RS06330_lanthipeptide
Lanthipeptides: IE339_RS06330_lanthipeptide
1
C T T N T F S L S D Y L G N T G G W C T A T K E C M P S C N
30
C T T N T F S L S D Y G N G G W C T A T E C M C
1
C T T N T F S L S D Y W G N K G G W C T A T H E C M S W C K
30
80.0%
NZ_CP084530.1 and 1 other:
NZ_CP084530.1 Lanthipeptides: LDO05_RS02075_lanthipeptide
Lanthipeptides: LDO05_RS02075_lanthipeptide
1
C T T N T F S L S D Y L G N T G G W C T A T K E C M P S C N
30
C T T N T F+L S+Y L G N G G W C T T K E C S C N
1
C T T N T F T L S N Y L G N N G G W C T L T K E C Q R S C N
30

#### MIBiG 4.0 matches for EGW35_RS11615

80.0%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
1
C T T N T F S L S D Y L G N T G G W C T A T K E C M P S C N
30
C T T N T F S L S+ L G N G G W C T T K E C P+C N
1
C T T N T F S L S N A L G N N G G W C T L T K E C Q P N C N
30
50.0%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
6
F S L S D Y L G N T G G W C T A T K E C M P S C N
30
+++S L G N G +C T T E C M P S C N
4
Y N I S C R L G N K G A Y C T L T V E C M P S C N
28
20.5%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
19
C T A T K E C M P S C N
30
C T +K E C P+C N
28
C T L S K E C Q P N C N
39
EGW35_RS11625
Leader:
MFTKNEKFEHNQEEESILEEISESEDTNGG
Core:
T T W A C V A V S T I V D A S I S L C P T T K C T S Q C S
Core with dehydrations:
Dhb Dhb W A Cys V A V Dha Dhb I V D A Dha I Dha L Cys P Dhb Dhb K Cys Dhb Dha Q Cys Dha

#### antiSMASH-DB 4.0 matches for EGW35_RS11625

100.0%
NZ_CP042598.1 and 3 others:
NZ_CP042598.1 Lanthipeptides: FUT28_RS13815_lanthipeptide NZ_RKNR01000012.1 Lanthipeptides: EGW35_RS11625_lanthipeptide NZ_RKNR01000012.1 Lanthipeptides: EGW35_RS11625_lanthipeptide
Lanthipeptides: FUT28_RS13815_lanthipeptide
1
T T W A C V A V S T I V D A S I S L C P T T K C T S Q C S
29
T T W A C V A V S T I V D A S I S L C P T T K C T S Q C S
1
T T W A C V A V S T I V D A S I S L C P T T K C T S Q C S
29
89.7%
NZ_JADPDT010000005.1 and 1 other:
NZ_JADPDT010000005.1 Lanthipeptides: I4V19_RS09875_lanthipeptide
Lanthipeptides: I4V19_RS09875_lanthipeptide
1
T T W A C V A V S T I V D A S I S L C P T T K C T S Q C S
29
T T W A C V A V S T+V+A S I S L C P T T K C T S+C S
1
T T W A C V A V S T V V E A S I S L C P T T K C T S K C S
29
69.0%
NZ_JABBGE010000004.1 and 1 other:
NZ_JABBGE010000004.1 Lanthipeptides: HHL19_RS13570_lanthipeptide
Lanthipeptides: HHL19_RS13570_lanthipeptide
1
T T W A C V---A V S T I V D A S I S L C P T T K C T S Q C
28
T T W+C A V+T+V A S C P T T K C T S Q C
1
T T W S C A V V T A V A T L V S A S A--C P T T K C T S Q C
29
with 90 more sequence matches
Only the first 10 are displayed here.
69.0%
NZ_LMEI01000006.1 and 1 other:
NZ_LMEI01000006.1 Lanthipeptides: ASC82_RS30550_lanthipeptide
Lanthipeptides: ASC82_RS30550_lanthipeptide
1
T T W A C V---A V S T I V D A S I S L C P T T K C T S Q C
28
T T W+C A V+T+V A S C P T T K C T S Q C
1
T T W S C A I V T A V A T L V S A S--A C P T T K C T S Q C
29
58.6%
NZ_LT630004.1:
Lanthipeptides: BQ5796_RS18310_lanthipeptide
1
T T W A C V A V S T I V D A S I S L C P T T K C T S Q C
28
T T C V ++ V S+S+C P T T K C T S Q C
2
T T L P C V G I T--V T I S V S M C P T T K C T S Q C
27
48.5%
NZ_QORY01000016.1 and 1 other:
NZ_QORY01000016.1 Lanthipeptides: DT250_RS18265_lanthipeptide
Lanthipeptides: DT250_RS18265_lanthipeptide
1
T T W A C V A V S T I V D A S I S L C P T T K C T S Q C
28
T T W C A+ T I A S + C P T T C+S+C
8
T T W G C-A I F T I--A S A A Q C P T T A C S S K C
32
45.7%
NZ_CM000721.1 and 9 others:
NZ_CP015591.1 Lanthipeptides: A7A70_RS27555_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29360_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29940_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29935_lanthipeptide NZ_NUBO01000052.1 Lanthipeptides: CN575_RS29785_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23040_lanthipeptide
Lanthipeptides: BCERE0010_RS29355_lanthipeptide
7
A V S T I V D A S I----S L C P T T K C T S Q C
28
A T I+ A+I S L C P T T K C T S+C
10
A T P T I I G A T I A V T A S L C P T T K C T S R C
35
45.7%
NZ_CP015591.1 and 15 others:
NZ_CP078085.1 Lanthipeptides: KU891_RS29355_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29350_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29345_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29340_lanthipeptide NZ_CP078085.1 Lanthipeptides: KU891_RS29335_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29930_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29925_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29920_lanthipeptide NZ_CP085411.1 Lanthipeptides: LIT28_RS29910_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptide NZ_QNUC01000031.1 Lanthipeptides: DN396_RS23050_lanthipeptide
Lanthipeptides: A7A70_RS27550_lanthipeptide
7
A V S T I V D A S I----S L C P T T K C T S Q C
28
A T I V+A+I S+C P T T K C T S+C
10
A T P T I V E A T I A A T V S I C P T T K C T S R C
35
45.2%
NC_018499.1 and 5 others:
NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27845_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptide NC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide
Lanthipeptides: BCK_RS27845_lanthipeptide
7
A V S T I V D A S I S L C P T T K C T S Q C
28
A T I V S+ +C P T T K C T S+C
10
A T P T I V A V S L G I C P T T K C T S K C
31
44.8%
NZ_BIFH01000022.1 and 1 other:
NZ_BIFH01000022.1 Lanthipeptides: EMA17_RS52585_lanthipeptide
Lanthipeptides: EMA17_RS52585_lanthipeptide
1
T T W A C V A V S T I V D A S I S L C P T T K C T S Q C
28
T+ C V A T++ A+ +C P T T C+S+C
3
T S A L C V A T I T L I T A T--M C P T T A C S S K C
28
43.5%
NZ_AKXV01000031.1 and 1 other:
NZ_AKXV01000031.1 Lanthipeptides: Y19_RS44045_lanthipeptide
Lanthipeptides: Y19_RS44045_lanthipeptide
1
T T W A C V---A V S T I V D A S I S L C P T T K C T S Q C
28
T T W+C A V+T+V A S C P T T K C T S Q C
18
T T W S C A I V T A V A T L V S A S A--C P T T K C T S Q C
46
41.4%
NZ_LR134483.1 and 1 other:
NZ_LR134483.1 Lanthipeptides: EL241_RS13590_lanthipeptide
Lanthipeptides: EL241_RS13590_lanthipeptide
12
V D A S I S L C P T T K C T S Q C
28
V S I+L C P T K C T S+C
7
V P L S I A L C P T A K C T S K C
23
41.0%
NZ_CP009280.1 and 1 other:
NZ_CP009280.1 Lanthipeptides: P40081_RS37160_lanthipeptide
Lanthipeptides: P40081_RS37160_lanthipeptide
1
T T W A C V A V S T I V D A S I S L C P T T K C T S Q C
28
++W C V + V D S +L C P T T K C T S+C
14
S S W P C V I G A--V D I S A N L C P T T K C T S K C
39

#### MIBiG 4.0 matches for EGW35_RS11625

31.0%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
18
L C P T T K C T S Q C
28
C P T T K C T S+C
16
F C P T T K C T S K C
26
29.7%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
12
V D A S I S L C P T T K C T S Q C
28
V S + C P T T K C T S+C
21
V G V S A A F C P T T K C T S R C
37
14.7%
BGC0000535.4 (ADJ56352.1):
Lanthipeptide: nisin A
15
S I S L C
19
S I S L C
3
S I S L C
7
EGW35_RS11665
Leader:
MKKPRFKNWRSFATLALLGQTISGAIGPMIAFA
Core:
D E I T H P Q T V T V H C D L S H L Y A V E G I
Core with dehydrations:
D E I Dhb H P Q Dhb V Dhb V H Cys D L Dha H L Y A V E G I

#### antiSMASH-DB 4.0 matches for EGW35_RS11665

100.0%
NZ_RKNR01000012.1:
Lanthipeptides: EGW35_RS11665_lanthipeptide
1
D E I T H P Q T V T V H C D L S H L Y A V E G I
24
D E I T H P Q T V T V H C D L S H L Y A V E G I
1
D E I T H P Q T V T V H C D L S H L Y A V E G I
24
16.0%
NZ_QICS01000003.1:
Lanthipeptides: allorf_263557_263733_lanthipeptide
13
C D L S H L Y A V E G I
24
C++ +L+A+ G+
3
C E V P Y L F A L R G V
14
11.8%
NC_021252.1:
Lanthipeptides: allorf_4521129_4521314_lanthipeptide
7
Q T V T V H C D L S H L Y A
20
+ + H C L L Y A
37
R A I G A H C P L W T L Y A
50

#### MIBiG 4.0 matches for EGW35_RS11665

14.3%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
8
T V T V H C
13
T+T V C
18
T L T V E C
23
11.8%
BGC0000535.4 (ADJ56352.1):
Lanthipeptide: nisin A
7
Q T V T V H C D L
15
+T T H C +
22
K T A T C H C S I
30
allorf_004148_004249
Leader:
MLFPSMYISLMNIYYQ
Core:
K Y Q L F I F F L C T Y V P S L Y
Core with dehydrations:
K Y Q L F I F F L Cys Dhb Y V P Dha L Y

#### antiSMASH-DB 4.0 matches for allorf_004148_004249

100.0%
NZ_RKNR01000012.1:
Lanthipeptides: allorf_004148_004249_lanthipeptide
1
K Y Q L F I F F L C T Y V P S L Y
17
K Y Q L F I F F L C T Y V P S L Y
1
K Y Q L F I F F L C T Y V P S L Y
17
31.6%
NZ_JAHXMW010000012.1 and 2 others:
NZ_JAHXMW010000012.1 Lanthipeptides: allorf_051847_052008_lanthipeptide NZ_VDYW01000008.1 Lanthipeptides: allorf_139136_139297_lanthipeptide
Lanthipeptides: allorf_051847_052008_lanthipeptide
7
F F L C T Y V P S
15
F F L C+Y+ S
1
F F L C S Y I T S
9
allorf_023523_023696
Leader:
MTISVVKIGQNLVVSLTA
Core:
N L I R K I P K H L P N L A T F E P E L L K R L T F F K K D K T C T F L L K S
Core with dehydrations:
N L I R K I P K H L P N L A Dhb F E P E L L K R L Dhb F F K K D K Dhb Cys Dhb F L L K Dha

#### antiSMASH-DB 4.0 matches for allorf_023523_023696

100.0%
NZ_RKNR01000012.1:
Lanthipeptides: allorf_023523_023696_lanthipeptide
1
N L I R K I P K H L P N L A T F E P E L L K R L T F F K K D K T C T F L L K S
39
N L I R K I P K H L P N L A T F E P E L L K R L T F F K K D K T C T F L L K S
1
N L I R K I P K H L P N L A T F E P E L L K R L T F F K K D K T C T F L L K S
39
30.8%
NZ_CP095740.1:
Lanthipeptides: allorf_1761125_1761268_lanthipeptide
4
R K I P K H----L P N L A T F E P E L L K R L T F F K K D K T C T F
35
R +P H L + F P L L+R L ++ T F
1
R A L P G H R F V G L S P M H R F L P N L L R R L K S I S C P R S M T F
36
17.5%
NZ_JANHJQ010000013.1:
Lanthipeptides: allorf_146838_147023_lanthipeptide
24
L T F F K K D K T C T F L L K
38
+T F K T C F L++
9
V T F V A K Q G T C A F L M Q
23

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.33 out of 27.78
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.54 out of 26.06
Confidence: medium
Additional weak hits (3):
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.50 out of 39.62
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 24.11 out of 35.63
Confidence: weak
NrdR
Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 20.22 out of 27.18
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

EGW35_RS11615 - Class II
  Cleavage pHMM score: -4.70
  RODEO score: 0
  Monoisotopic mass: 3042.3 Da
  Molecular weight: 3044.4 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3062.4 Da N = 1
    3080.4 Da N = 2
    3098.4 Da N = 3
    3116.4 Da N = 4
    3134.5 Da N = 5
EGW35_RS11625 - Class II
  Cleavage pHMM score: -1.20
  RODEO score: 0
  Monoisotopic mass: 2777.4 Da
  Molecular weight: 2779.2 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2797.2 Da N = 1
    2815.2 Da N = 2
    2833.3 Da N = 3
    2851.3 Da N = 4
    2869.3 Da N = 5
    2887.3 Da N = 6
    2905.3 Da N = 7
EGW35_RS11665 - Class II
  Cleavage pHMM score: -4.80
  RODEO score: 0
  Monoisotopic mass: 2604.3 Da
  Molecular weight: 2605.9 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2623.9 Da N = 1
    2641.9 Da N = 2
    2659.9 Da N = 3
allorf_004148_004249 - Class II
  Cleavage pHMM score: -7.10
  RODEO score: 0
  Monoisotopic mass: 2108.1 Da
  Molecular weight: 2109.5 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2127.5 Da N = 1
allorf_023523_023696 - Class II
  Cleavage pHMM score: -6.30
  RODEO score: 0
  Monoisotopic mass: 4550.7 Da
  Molecular weight: 4553.5 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4571.5 Da N = 1
    4589.5 Da N = 2
    4607.5 Da N = 3
    4625.6 Da N = 4
EGW35_RS11615 - Class II
  Cleavage pHMM score: -4.70
  RODEO score: 0
  Monoisotopic mass: 3042.3 Da
  Molecular weight: 3044.4 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3062.4 Da N = 1
    3080.4 Da N = 2
    3098.4 Da N = 3
    3116.4 Da N = 4
    3134.5 Da N = 5
EGW35_RS11625 - Class II
  Cleavage pHMM score: -1.20
  RODEO score: 0
  Monoisotopic mass: 2777.4 Da
  Molecular weight: 2779.2 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2797.2 Da N = 1
    2815.2 Da N = 2
    2833.3 Da N = 3
    2851.3 Da N = 4
    2869.3 Da N = 5
    2887.3 Da N = 6
    2905.3 Da N = 7
allorf_004148_004249 - Class II
  Cleavage pHMM score: -7.10
  RODEO score: 0
  Monoisotopic mass: 2108.1 Da
  Molecular weight: 2109.5 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2127.5 Da N = 1

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MogR | Repressor of flagellar motility genes

NZ_RKNR01000001.1 - Region 1 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 117,430 - 138,314 nt. (total: 20,885 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: peptidase
EGW35_RS00650: methionine aminopeptidase

smcogs
  SMCOG1172: methionine aminopeptidase

Ligases: synthetase
EGW35_RS00620: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0000639.3 |  | 0.34 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.34 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0001605.3 |  | 0.32 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0000633.3 |  | 0.31 | terpene | carotenoid | Streptomyces avermitilis
BGC0001227.3 |  | 0.31 | terpene | isorenieratene | Streptomyces collinus Tu 365
BGC0000648.3 |  | 0.31 | terpene | carotenoid | Myxococcus xanthus
BGC0002181.3 |  | 0.31 | terpene | pleuromutilin | Rhodocybe pseudopiperita

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0000639.3 |  | 0.34 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.34 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0001605.3 |  | 0.32 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0000633.3 |  | 0.31 | terpene | carotenoid | Streptomyces avermitilis
BGC0001227.3 |  | 0.31 | terpene | isorenieratene | Streptomyces collinus Tu 365
BGC0000648.3 |  | 0.31 | terpene | carotenoid | Myxococcus xanthus
BGC0002181.3 |  | 0.31 | terpene | pleuromutilin | Rhodocybe pseudopiperita

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
EGW35_RS00620: PT_FPPS_like
Domain 1 (30 - 278): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  IPP, DMAPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.69 out of 27.78
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.51 out of 27.78
Confidence: strong
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.31 out of 18.46
Confidence: strong
Additional weak hits (1):
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.88 out of 30.98
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
RpoN | Regulator of nitrogen assimilation and virulence

NZ_RKNR01000002.1 - Region 1 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 320,563 - 359,668 nt. (total: 39,106 nt) Show pHMM detection rules used
Region on contig edge.
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase reductase
EGW35_RS03320: aldo/keto reductase family oxidoreductase

smcogs
  SMCOG1039: aldo/keto reductase family oxidoreductase

EGW35_RS03340: hydroxymethylglutaryl-CoA reductase

smcogs
  SMCOG1187: hydroxymethylglutaryl-CoA reductase

Hydrolases: back translocase hydrolase
EGW35_RS03255: alpha/beta hydrolase fold protein

smcogs
  SMCOG1036: alpha/beta hydrolase fold protein

EGW35_RS03275: GTP-binding protein LepA

smcogs
  SMCOG1190: GTP-binding protein LepA

Ligases: synthase
EGW35_RS03345: hydroxymethylglutaryl-CoA synthase

smcogs
  SMCOG1043: hydroxymethylglutaryl-CoA synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000866.5 |  | 0.51 | other (other) | polyhydroxyalkanoate | Burkholderia sp. DSM 9242
BGC0000867.3 |  | 0.49 | other (other) | polyhydroxyalkanoic acids | Ectothiorhodospira shaposhnikovii
BGC0000255.5 |  | 0.42 | PKS | pederin | Uncultured bacterium
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000616.4 |  | 0.40 | ribosomal | amylocyclicin | Bacillus velezensis FZB42
BGC0002561.3 |  | 0.40 | other (other) | phenazine SA, phenazine SB, phenazine SC | Streptomyces sp.
BGC0001639.3 |  | 0.40 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0000486.4 |  | 0.40 | ribosomal | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0002707.2 |  | 0.39 | terpene | (+)-δ-cadinol | Coniophora puteana RWD-64-598 SS2
BGC0001887.3 |  | 0.38 | ribosomal | huazacin | Bacillus thuringiensis serovar huazhongensis BGSC 4BD1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000866.5 |  | 0.51 | other (other) | polyhydroxyalkanoate | Burkholderia sp. DSM 9242
BGC0000867.3 |  | 0.49 | other (other) | polyhydroxyalkanoic acids | Ectothiorhodospira shaposhnikovii
BGC0000255.5 |  | 0.42 | PKS | pederin | Uncultured bacterium
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000616.4 |  | 0.40 | ribosomal | amylocyclicin | Bacillus velezensis FZB42
BGC0002561.3 |  | 0.40 | other (other) | phenazine SA, phenazine SB, phenazine SC | Streptomyces sp.
BGC0001639.3 |  | 0.40 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0000486.4 |  | 0.40 | ribosomal | butyrivibriocin AR10 | Butyrivibrio fibrisolvens
BGC0002707.2 |  | 0.39 | terpene | (+)-δ-cadinol | Coniophora puteana RWD-64-598 SS2
BGC0001887.3 |  | 0.38 | ribosomal | huazacin | Bacillus thuringiensis serovar huazhongensis BGSC 4BD1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.54 out of 23.79
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.18 out of 20.97
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.37 out of 26.06
Confidence: medium
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.52 out of 25.88
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.02 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.64 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.42 out of 27.78
Confidence: medium
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.39 out of 25.88
Confidence: medium
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.27 out of 26.85
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.75 out of 28.19
Confidence: medium
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.07 out of 32.93
Confidence: medium
Additional weak hits (5):
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 19.95 out of 25.88
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.68 out of 32.74
Confidence: weak
DosR
Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 22.55 out of 29.51
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 26.22 out of 33.14
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 26.23 out of 33.14
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
IolR | Regulator of the inositol catabolism
LexA variant 3 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
PsrA | Oleic acid responsive regulator
RutR | Regulator of the pyrimidine and purine metabolism
ZuR variant 1 | Zinc-responsive repressor

NZ_RKNR01000007.1 - Region 1 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 77,036 - 97,926 nt. (total: 20,891 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
EGW35_RS08475: dehydrogenase

smcogs
  SMCOG1222: dehydrogenase

Transferases: kinase
EGW35_RS08500: glycerol kinase

smcogs
  SMCOG1210: glycerol kinase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000647.3 |  | 0.58 | terpene | carotenoid | Rhodobacter sphaeroides
BGC0001456.3 |  | 0.49 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000664.5 |  | 0.49 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000646.5 |  | 0.49 | terpene | β-carotein | uncultured bacterium
BGC0000645.3 |  | 0.47 | terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0000656.5 |  | 0.47 | terpene | zeaxanthin | Xanthobacter autotrophicus Py2
BGC0000639.3 |  | 0.47 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000640.3 |  | 0.47 | terpene | carotenoid | Enterobacteriaceae bacterium DC404
BGC0000641.3 |  | 0.47 | terpene | carotenoid | Enterobacteriaceae bacterium DC416
BGC0000633.3 |  | 0.46 | terpene | carotenoid | Streptomyces avermitilis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000647.3 |  | 0.58 | terpene | carotenoid | Rhodobacter sphaeroides
BGC0001456.3 |  | 0.49 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000664.5 |  | 0.49 | terpene | isorenieratene | Streptomyces griseus subsp. griseus NBRC 13350
BGC0000646.5 |  | 0.49 | terpene | β-carotein | uncultured bacterium
BGC0000645.3 |  | 0.47 | terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0000656.5 |  | 0.47 | terpene | zeaxanthin | Xanthobacter autotrophicus Py2
BGC0000639.3 |  | 0.47 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000640.3 |  | 0.47 | terpene | carotenoid | Enterobacteriaceae bacterium DC404
BGC0000641.3 |  | 0.47 | terpene | carotenoid | Enterobacteriaceae bacterium DC416
BGC0000633.3 |  | 0.46 | terpene | carotenoid | Streptomyces avermitilis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene | C30 carotenoid | diapophytoene | C30 | acyclic | none

Genes with terpene domains:
EGW35_RS08470: PT_phytoene_like
Domain 1 (14 - 284): Prenyltransferase; Phytoene synthase like
Subtype: Diapophytoene synthase

Reactions:
  FPP → diapophytoene

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.82 out of 18.46
Confidence: medium
Additional weak hits (3):
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.21 out of 27.04
Confidence: weak
DosR
Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 19.86 out of 29.51
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.33 out of 31.73
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
FPP | Farnesyl diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
RpoN | Regulator of nitrogen assimilation and virulence

NZ_RKNR01000009.1 - Region 1 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 16,627 nt. (total: 16,627 nt) Show pHMM detection rules used
Region on contig edge.
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001291.3 |  | 0.41 | ribosomal | enterocin NKR-5-3B | Enterococcus faecium
BGC0000494.5 |  | 0.40 | ribosomal | uberolysin | Streptococcus uberis
BGC0000540.5 |  | 0.32 | ribosomal | paenibacillin | Paenibacillus polymyxa OSY-DF
BGC0002579.2 |  | 0.31 | ribosomal | carnobacteriocin XY | Carnobacterium maltaromaticum
BGC0000624.3 |  | 0.31 | ribosomal | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0002667.2 |  | 0.27 | ribosomal | estericin A | Clostridium estertheticum
BGC0002360.3 |  | 0.18 | NRPS | depsibosamycin B, depsibosamycin C, depsibosamycin D | Streptomyces aurantiacus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001291.3 |  | 0.41 | ribosomal | enterocin NKR-5-3B | Enterococcus faecium
BGC0000494.5 |  | 0.40 | ribosomal | uberolysin | Streptococcus uberis
BGC0000540.5 |  | 0.32 | ribosomal | paenibacillin | Paenibacillus polymyxa OSY-DF
BGC0002579.2 |  | 0.31 | ribosomal | carnobacteriocin XY | Carnobacterium maltaromaticum
BGC0000624.3 |  | 0.31 | ribosomal | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0002667.2 |  | 0.27 | ribosomal | estericin A | Clostridium estertheticum
BGC0002360.3 |  | 0.18 | NRPS | depsibosamycin B, depsibosamycin C, depsibosamycin D | Streptomyces aurantiacus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.21 out of 26.06
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.23 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.78 out of 27.78
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.71 out of 20.97
Confidence: medium
Additional weak hits (2):
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 20.76 out of 27.55
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 24.41 out of 30.97
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis