GCF_003468995.1 - 5 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_QSJW01000001.1 (Blautia obeum)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	t3nrps-iterative	264,683	307,581

NZ_QSJW01000010.1 (Blautia obeum)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 2.1	ranthipeptide	30,720	52,313

NZ_QSJW01000012.1 (Blautia obeum)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 4.1	lanthipeptide-class-ii	85,438	113,276

NZ_QSJW01000002.1 (Blautia obeum)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 12.1	cyclic-lactone-autoinducer	391,971	412,703

NZ_QSJW01000007.1 (Blautia obeum)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 22.1	terpene-precursor	206,583	227,470

Region	Type	From	To
Region 1.1	t3nrps-iterative	264,683	307,581
Region 2.1	ranthipeptide	30,720	52,313
Region 4.1	lanthipeptide-class-ii	85,438	113,276
Region 12.1	cyclic-lactone-autoinducer	391,971	412,703
Region 22.1	terpene-precursor	206,583	227,470

No secondary metabolite regions were found in these records:: NZ_QSJW01000011.1 (Blautia obeum); NZ_QSJW01000013.1 (Blautia obeum); NZ_QSJW01000014.1 (Blautia obeum); NZ_QSJW01000015.1 (Blautia obeum); NZ_QSJW01000016.1 (Blautia obeum); NZ_QSJW01000017.1 (Blautia obeum); NZ_QSJW01000018.1 (Blautia obeum); NZ_QSJW01000019.1 (Blautia obeum); NZ_QSJW01000020.1 (Blautia obeum); NZ_QSJW01000021.1 (Blautia obeum); NZ_QSJW01000022.1 (Blautia obeum); NZ_QSJW01000023.1 (Blautia obeum); NZ_QSJW01000024.1 (Blautia obeum); NZ_QSJW01000003.1 (Blautia obeum); NZ_QSJW01000004.1 (Blautia obeum); NZ_QSJW01000005.1 (Blautia obeum); NZ_QSJW01000006.1 (Blautia obeum); NZ_QSJW01000008.1 (Blautia obeum); NZ_QSJW01000009.1 (Blautia obeum)

Compact view

NZ_QSJW01000001.1 - Region 1 - t3nrps-iterative

Download region GenBank file

Download region SVG

Location: 264,683 - 307,581 nt. (total: 42,899 nt) Show pHMM detection rules used

t3nrps-iterative: (AMP-binding and PP-binding and (DUF98 or Orn_Arg_deC_N or Orn_DAP_Arg_deC) and not ATP-grasp)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

DW767_RS01245: NADH:flavin oxidoreductase/NADH oxidase

smcogs: SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

Hydrolases: hydrolase

DW767_RS01285: hydrolase

smcogs: SMCOG1179: hydrolase

DW767_RS01365: amidohydrolase

smcogs: SMCOG1244: amidohydrolase

Lyases: decarboxylase

DW767_RS01305: diaminopimelate decarboxylase

smcogs: SMCOG1264: diaminopimelate decarboxylase

Ligases: ligase

DW767_RS01300: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.60	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000307.4	0.60	NRPS	AbT1	Aureobasidium pullulans
BGC0001408.5	0.45	other (other)	xanthoferrin	Xanthomonas oryzae pv. oryzae KACC 10331
BGC0000308.5	0.43	NRPS	aureusimine A, aureusimine B, aureusimine C	Staphylococcus aureus subsp. aureus str. JKD6008
BGC0000885.3	0.42	other (other)	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0000310.5	0.42	NRPS	bacitracin	Bacillus licheniformis
BGC0000527.5	0.42	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0002071.2	0.42	NRPS	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0001733.3	0.41	ribosomal	PcpA	Pleurocapsa sp. PCC 7327
BGC0000550.3	0.41	ribosomal	salivaricin G32	Streptococcus salivarius

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.60	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000307.4	0.60	NRPS	AbT1	Aureobasidium pullulans
BGC0001408.5	0.45	other (other)	xanthoferrin	Xanthomonas oryzae pv. oryzae KACC 10331
BGC0000308.5	0.43	NRPS	aureusimine A, aureusimine B, aureusimine C	Staphylococcus aureus subsp. aureus str. JKD6008
BGC0000885.3	0.42	other (other)	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0000310.5	0.42	NRPS	bacitracin	Bacillus licheniformis
BGC0000527.5	0.42	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0002071.2	0.42	NRPS	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0001733.3	0.41	ribosomal	PcpA	Pleurocapsa sp. PCC 7327
BGC0000550.3	0.41	ribosomal	salivaricin G32	Streptococcus salivarius

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.83 out of 27.78

Confidence: strong

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.60 out of 21.55

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.89 out of 18.16

Confidence: strong

Additional weak hits (6):

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 22.39 out of 28.14

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.42 out of 36.54

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 19.14 out of 22.40

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.45 out of 20.01

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.96 out of 31.73

Confidence: weak

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 20.59 out of 27.18

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

TFBS Finder

NRPS/PKS substrate predictions

DW767_RS01300: X

AMP-binding (10..412): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: FHFAFDVSVKDTIWFFSGEVNLYGPTEITCNCTY
Nearest Stachelhaus code(s):: Ser DVWHFSLVDK (59% 8Å match)
Stachelhaus code match:: 60% (weak)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
ArcA	Repressor of carbon oxidation
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria

NZ_QSJW01000010.1 - Region 1 - ranthipeptide

Download region GenBank file

Download region SVG

Location: 30,720 - 52,313 nt. (total: 21,594 nt) Show pHMM detection rules used

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	ranthipeptide	Similarity score	Type	Compound(s)	Organism
BGC0002306.2		0.47	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842

Reference	Aggregated	Similarity score	Type	Compound(s)	Organism
BGC0002306.2		0.47	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.77 out of 27.78

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.53 out of 20.97

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.71 out of 20.47

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.83 out of 27.78

Confidence: medium

Additional weak hits (2):

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.25 out of 30.97

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.87 out of 33.14

Confidence: weak

RREFinder

TFBS Finder

RRE predictions

: RRE type: Ranthipeptide_rSAM_RRE; Location: 1 - 102; Score: 92.4

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ToxT	Regulator of MSHA biosynthesis
VqsM	Regulator of quorum-sensing signalling systems

NZ_QSJW01000012.1 - Region 1 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 85,438 - 113,276 nt. (total: 27,839 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

DW767_RS16310: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

DW767_RS16355: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.57	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000552.3	0.55	ribosomal	SmbA, SmbB	Streptococcus mutans
BGC0001210.5	0.53	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000516.4	0.51	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000528.5	0.51	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000497.3	0.51	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0002110.3	0.50	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000500.5	0.50	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0001391.3	0.50	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0001229.4	0.50	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.57	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000552.3	0.55	ribosomal	SmbA, SmbB	Streptococcus mutans
BGC0001210.5	0.53	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000516.4	0.51	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000528.5	0.51	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000497.3	0.51	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti
BGC0002110.3	0.50	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000500.5	0.50	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0001391.3	0.50	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0001229.4	0.50	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for DW767_RS16310

DW767_RS16305

Leader:

MKKNYRNPMTRPENFMNPAGNVMKEIKEADLNNFSAGAGEPRVSDGS

Core:

QFCTSTKECNWGTIMFVCC

Core with dehydrations:

QFCysDhbDhaDhbKECysNWGDhbIMFVCysCys

antiSMASH-DB 4.0 matches for DW767_RS16305

100.0%

NZ_CP102267.1and 11 others:

NZ_FMUW01000051.1 Lanthipeptides: BLP57_RS16830_lanthipeptideNZ_JAQDBP010000004.1 Lanthipeptides: PGY07_RS07130_lanthipeptideNZ_JAQEHQ010000024.1 Lanthipeptides: PGR68_RS13915_lanthipeptideNZ_JAQESL010000043.1 Lanthipeptides: PG840_RS15980_lanthipeptideNZ_JAQESS010000001.1 Lanthipeptides: PG808_RS00050_lanthipeptideNZ_LN913006.1 Lanthipeptides: BN3261_RS01470_lanthipeptideNZ_QRPQ01000011.1 Lanthipeptides: DWZ74_RS14610_lanthipeptideNZ_QRZZ01000003.1 Lanthipeptides: DWV87_RS03120_lanthipeptideNZ_QSJW01000012.1 Lanthipeptides: DW767_RS16305_lanthipeptideNZ_QSKF01000004.1 Lanthipeptides: DW740_RS06255_lanthipeptideNZ_QUJJ01000004.1 Lanthipeptides: DW748_RS03580_lanthipeptide

Lanthipeptides: NQ550_RS04155_lanthipeptide

QFCTSTKECNWGTIMFVCC

42.9%

NZ_QRHZ01000008.1and 2 others:

NZ_QSRF01000021.1 Lanthipeptides: DXC87_RS15310_lanthipeptideNZ_QUEQ01000033.1 Lanthipeptides: DXA48_RS19000_lanthipeptide

Lanthipeptides: DW272_RS13830_lanthipeptide

FCTSTKECNWGTIMFVCC

FCTST ECN GT+ CC

FCTSTGECNMGTLNIFCC

40.0%

NZ_JAFCGV010000005.1:

Lanthipeptides: JQI09_RS04275_lanthipeptide

TSTKECNWGTIMFVCC

T+T EC GT FVCC

TATSECYLGTFAFVCC

with 18 more sequence matches

Only the first 10 are displayed here.

40.0%

NZ_WBPF01000002.1:

Lanthipeptides: F8162_RS00195_lanthipeptide

QFCTSTKECNWGT--IMFVCC

QF T + EC+W T +F CC

QFDTISHECHWNTWQFLFTCC

36.0%

NZ_CP045267.1and 1 other:

NZ_CP045267.1 Lanthipeptides: FDZ14_RS00155_lanthipeptide

Lanthipeptides: FDZ14_RS00155_lanthipeptide

TSTKECNWGTIMFVCC

T+T EC GT F CC

TATSECYLGTFAFACC

34.6%

NZ_CP117876.1:

Lanthipeptides: PQ460_RS01735_lanthipeptide

TSTKECNWGTIMFVCC

T+T EC GT+ F+CC

TATSECYLGTVAFICC

33.3%

NZ_CYXV01000003.1:

Lanthipeptides: ARB75_RS04585_lanthipeptide

CTSTKECNWGTIMFVCC

CT T ECN GT + CC

CTLTGECNIGTHIKFCC

29.2%

NC_012470.1and 42 others:

NZ_CAAHGW010000010.1 Lanthipeptides: E9435_RS08895_lanthipeptideNZ_CAAHHE010000002.1 Lanthipeptides: E9499_RS02930_lanthipeptideNZ_CAAHHF010000009.1 Lanthipeptides: E9478_RS08675_lanthipeptideNZ_CAAHHN010000003.1 Lanthipeptides: E9502_RS05705_lanthipeptideNZ_CAAHHU010000009.1 Lanthipeptides: E9510_RS08735_lanthipeptideNZ_CAAHHW010000012.1 Lanthipeptides: E9525_RS08985_lanthipeptideNZ_CAAHIB010000001.1 Lanthipeptides: E9539_RS01075_lanthipeptideNZ_CAAHIV010000024.1 Lanthipeptides: E9612_RS09255_lanthipeptideNZ_CAAHKK010000019.1 Lanthipeptides: E9649_RS08770_lanthipeptideNZ_CAAHKP010000014.1 Lanthipeptides: E9652_RS08920_lanthipeptideNZ_CAAHKQ010000003.1 Lanthipeptides: E9664_RS02160_lanthipeptideNZ_CAAHKY010000014.1 Lanthipeptides: E9668_RS09650_lanthipeptideNZ_CAAHLP010000002.1 Lanthipeptides: E9684_RS03445_lanthipeptideNZ_CAAHQE010000012.1 Lanthipeptides: E9931_RS08815_lanthipeptideNZ_CAAHRY010000002.1 Lanthipeptides: E9986_RS03175_lanthipeptideNZ_CAAIES010000002.1 Lanthipeptides: FAH15_RS02475_lanthipeptideNZ_CAAIIA010000012.1 Lanthipeptides: FAH55_RS08475_lanthipeptideNZ_CAAIJM010000015.1 Lanthipeptides: FAI23_RS09585_lanthipeptideNZ_CAAINV010000013.1 Lanthipeptides: FAI86_RS09025_lanthipeptideNZ_CAAIRS010000012.1 Lanthipeptides: FAK24_RS08485_lanthipeptideNZ_CAAJFI010000013.1 Lanthipeptides: FAP60_RS08495_lanthipeptideNZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS10120_lanthipeptideNZ_CP018188.1 Lanthipeptides: BSR19_RS11185_lanthipeptideNZ_CP029398.1 Lanthipeptides: DF184_RS05190_lanthipeptideNZ_CP035426.1 Lanthipeptides: ETT73_RS02600_lanthipeptideNZ_CP035437.1 Lanthipeptides: ETT62_RS06670_lanthipeptideNZ_CP035443.1 Lanthipeptides: ETT56_RS07260_lanthipeptideNZ_CP066093.1 Lanthipeptides: I6I02_RS07305_lanthipeptideNZ_CP078012.1 Lanthipeptides: KV238_RS09825_lanthipeptideNZ_JAFLMI010000009.1 Lanthipeptides: J0638_RS05340_lanthipeptideNZ_JALDUD010000010.1 Lanthipeptides: M1G10_RS09695_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09305_lanthipeptideNZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09305_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06590_lanthipeptideNZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06590_lanthipeptideNZ_KV832031.1 Lanthipeptides: HMPREF2637_RS10860_lanthipeptideNZ_LR738724.1 Lanthipeptides: GPW69_RS05070_lanthipeptideNZ_LS483425.1 Lanthipeptides: DQN36_RS06745_lanthipeptideNZ_NWMU01000024.1 Lanthipeptides: CO197_RS09155_lanthipeptideNZ_PKIA01000004.1 Lanthipeptides: CYK22_RS04325_lanthipeptideNZ_VMMF01000004.1 Lanthipeptides: HT717_RS01580_lanthipeptideNZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05570_lanthipeptide

Lanthipeptides: SZO_RS10260_lanthipeptide

TSTKECNWGTI--MFVCC

T + EC W ++ +F CC

TISAECRWNSLQAIFTCC

29.2%

NZ_ALSD01000046.1and 5 others:

NZ_CAJHJS010000009.1 Lanthipeptides: JMX87_RS06795_lanthipeptideNZ_CM001076.1 Lanthipeptides: SDD27957_RS10995_lanthipeptideNZ_GL636070.1 Lanthipeptides: HMPREF9171_RS1000000113590_lanthipeptideNZ_LR793258.1 Lanthipeptides: HV369_RS03150_lanthipeptideNZ_LT545678.1 Lanthipeptides: BJR96_RS11590_lanthipeptide

Lanthipeptides: SAG0161_RS1000000124770_lanthipeptide

TSTKECNWGTI--MFVCC

T + EC W ++ +F CC

TISAECRWNSLQAIFSCC

27.6%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06310_lanthipeptide

Lanthipeptides: EG886_RS06310_lanthipeptide

QFCTSTKEC

QFCT TKEC

QFCTLTKEC

26.3%

NZ_CP059557.1:

Lanthipeptides: H2Q94_RS19875_lanthipeptide

KECNWGTIMFVC

+ C+WG + VC

QSCSWGPVTAVC

25.0%

NC_021362.1and 29 others:

NC_021362.1 Lanthipeptides: BALI_RS00925_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptideNZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptideNZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptideNZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptideNZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptideNZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptideNZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptideNZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptideNZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptideNZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptideNZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptideNZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptideNZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptideNZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptideNZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptide

Lanthipeptides: BALI_RS00925_lanthipeptide

QFCTSTKEC

Q+CT TKEC

QWCTLTKEC

24.1%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06305_lanthipeptide

Lanthipeptides: EG886_RS06305_lanthipeptide

QFCTSTKEC

+FCT TKEC

RFCTLTKEC

MIBiG 4.0 matches for DW767_RS16305

26.3%

BGC0000503.5 (cinA):

Lanthipeptide: cinnamycin

KECNWGTIMFVC

+ C++G FVC

QSCSFGPFTFVC

20.0%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

FCTSTKEC

+CT TKEC

WCTLTKEC

17.9%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

FCTSTKEC

+CT T EC

YCTLTVEC

with 3 more sequence matches

13.6%

BGC0000553.3 (SSGG_RS09925):

Lanthipeptide: SRO15-2212

CNWGTIMFVCC

C + ++ V C

CEYSSLSVVLC

12.8%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

CTSTKEC

CT +KEC

CTLSKEC

10.8%

BGC0001229.4 (SBI_06989)and 1 other:

BGC0002110.3 (QKV49894.1) Lanthipeptide: birimositide

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

FCTSTK

FC +TK

FCPTTK

DW767_RS16350

Leader:

MRKFDRTNMKYNNPAGDLLTELEAA

Core:

DLTSNKVDSLASSGVVCTISVECGSIFTLACC

Core with dehydrations:

DLDhbDhaNKVDDhaLADhaDhaGVVCysDhbIDhaVECysGDhaIFDhbLACysCys

antiSMASH-DB 4.0 matches for DW767_RS16350

100.0%

NZ_JAQDBP010000004.1and 18 others:

NZ_JAQDBP010000004.1 Lanthipeptides: PGY07_RS07085_lanthipeptideNZ_JAQEAL010000002.1 Lanthipeptides: PGU65_RS02165_lanthipeptideNZ_JAQESL010000010.1 Lanthipeptides: PG840_RS09145_lanthipeptideNZ_JAQEUC010000007.1 Lanthipeptides: PG788_RS06860_lanthipeptideNZ_QRHW01000005.1 Lanthipeptides: DW641_RS05035_lanthipeptideNZ_QROS01000011.1 Lanthipeptides: DW021_RS13630_lanthipeptideNZ_QRPQ01000001.1 Lanthipeptides: DWZ74_RS02490_lanthipeptideNZ_QRZZ01000003.1 Lanthipeptides: DWV87_RS03165_lanthipeptideNZ_QRZZ01000003.1 Lanthipeptides: DWV87_RS03165_lanthipeptideNZ_QSJW01000012.1 Lanthipeptides: DW767_RS16350_lanthipeptideNZ_QSJW01000012.1 Lanthipeptides: DW767_RS16350_lanthipeptideNZ_QSKF01000004.1 Lanthipeptides: DW740_RS06305_lanthipeptideNZ_QSKF01000004.1 Lanthipeptides: DW740_RS06305_lanthipeptideNZ_QTZB01000014.1 Lanthipeptides: DXC15_RS13895_lanthipeptideNZ_QUCI01000011.1 Lanthipeptides: DW648_RS10830_lanthipeptideNZ_QUJJ01000004.1 Lanthipeptides: DW748_RS03630_lanthipeptideNZ_QUJJ01000004.1 Lanthipeptides: DW748_RS03630_lanthipeptideNZ_QUKU01000006.1 Lanthipeptides: DXC27_RS05470_lanthipeptide

Lanthipeptides: PGY07_RS07085_lanthipeptide

DLTSNKVDSLASSGVVCTISVECGSIFTLACC

62.5%

NZ_CP022413.2and 1 other:

NZ_JAQEYW010000009.1 Lanthipeptides: PG422_RS09400_lanthipeptide

Lanthipeptides: CGC63_RS01420_lanthipeptide

SGVVCTISVECGSIFTLACC

40.6%

NZ_FNUH01000004.1and 1 other:

NZ_FOGM01000011.1 Lanthipeptides: BMX20_RS07220_lanthipeptide

Lanthipeptides: BLU50_RS05815_lanthipeptide

SGVVCTISVEC-----GSIFTLACC

GVV T+S EC SIFT CC

QGVVPTVSYECRMNSWQSIFT--CC

with 122 more sequence matches

Only the first 10 are displayed here.

37.5%

NZ_AUBN01000022.1:

Lanthipeptides: G448_RS16025_lanthipeptide

ASSGVVCTISVECGSIFTLAC

ASSG CT+++ECG+ F AC

ASSGWFCTLTIECGT-FICAC

37.5%

NZ_CP061274.1and 1 other:

NZ_JADKRR010000001.1 Lanthipeptides: ITJ40_RS10085_lanthipeptide

Lanthipeptides: H9X71_RS09850_lanthipeptide

ASSGVVCTISVECGSIFTLAC

ASSG +CT+++ECG+ F AC

ASSGWLCTLTIECGT-FICAC

36.4%

NZ_CP040409.1and 4 others:

NZ_CP040411.1 Lanthipeptides: FE334_RS06825_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS09430_lanthipeptideNZ_JH601103.1 Lanthipeptides: HMPREF9703_RS02710_lanthipeptideNZ_NAQX01000046.1 Lanthipeptides: B8A46_RS06295_lanthipeptide

Lanthipeptides: FE336_RS08590_lanthipeptide

SSGVVCTISVECGSIFTLACC

S G CTI+ EC +FT+ACC

SCGRACTITAEC-PVFTVACC

34.4%

NZ_CP069183.1:

Lanthipeptides: LLNCDO700_RS13730_lanthipeptide

ASSGVVCTISVECG---SIFTLACC

SGV+ TIS EC F CC

GGSGVIHTISHECNMNSWQFVFTCC

34.4%

NZ_CP086242.1and 1 other:

NZ_CP086245.1 Lanthipeptides: LL037_RS25615_lanthipeptide

Lanthipeptides: LL038_RS25355_lanthipeptide

ASSGVVCTISVECGSIFTLACC

ASSG +CT + EC + F+ CC

ASSGAICTATTEC-TYFSAICC

32.4%

NZ_JADNMH010000005.1:

Lanthipeptides: I2E99_RS07105_lanthipeptide

SSGVVCTISVECGSIFTLACC

S G CTI+ EC I T+ CC

SCGRRCTITTEC-PIATVVCC

32.4%

NZ_JAESIP010000017.1and 3 others:

NZ_LT907978.1 Lanthipeptides: EHLA_RS12685_lanthipeptideNZ_QRYY01000029.1 Lanthipeptides: DWW21_RS18370_lanthipeptideNZ_SPFW01000044.1 Lanthipeptides: FGQ81_RS16590_lanthipeptide

Lanthipeptides: JMK14_RS12260_lanthipeptide

ASSGVVCTISVECGSIFTLACC

AS G +CT + EC I T+ CC

ASCGRLCTGTAEC-PIMTIICC

31.2%

NZ_AP025017.1:

Lanthipeptides: MANAM107_RS05920_lanthipeptide

SGVVCTISVECG---SIFTLACC

+GV+ TIS EC F CC

NGVITTISHECHLNTWAFAFTCC

31.2%

NZ_CP034248.1:

Lanthipeptides: EIM92_RS14995_lanthipeptide

ASSGVVCTISVEC

AS GV+CTIS EC

ASGGVICTISHEC

31.2%

NZ_CP114875.1:

Lanthipeptides: O4Z47_RS14375_lanthipeptide

SSGVVCTISVECGSIFTLACC

SSG +CT++ EC + T CC

SSGDICTLTSECDHLATWVCC

MIBiG 4.0 matches for DW767_RS16350

21.9%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

LASSGVVCTISVEC

L + G CT++VEC

LGNKGAYCTLTVEC

18.8%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

DSLASSGVVCTISVEC

++L ++G CT++ EC

NALGNNGGWCTLTKEC

12.8%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

CTISVECGS

CT+S EC

CTLSKECQP

allorf_092199_092297

Leader:

MIRSSIIFFVLNKLQGS

Core:

CQVSVRFLSEKYIIL

Core with dehydrations:

CysQVDhaVRFLDhaEKYIIL

antiSMASH-DB 4.0 matches for allorf_092199_092297

100.0%

NZ_CP102267.1and 7 others:

NZ_JAQDBP010000004.1 Lanthipeptides: allorf_177044_177142_lanthipeptideNZ_JAQEHQ010000024.1 Lanthipeptides: allorf_20164_20253_lanthipeptideNZ_JAQESL010000043.1 Lanthipeptides: allorf_02084_02182_lanthipeptideNZ_JAQESS010000001.1 Lanthipeptides: allorf_017059_017148_lanthipeptideNZ_LN913006.1 Lanthipeptides: allorf_0097924_0098022_lanthipeptideNZ_QRPQ01000011.1 Lanthipeptides: allorf_103379_103477_lanthipeptideNZ_QSJW01000012.1 Lanthipeptides: allorf_092199_092297_lanthipeptide

Lanthipeptides: allorf_0889319_0889417_lanthipeptide

CQVSVRFLSEKYIIL

Lanthipeptide(s) for DW767_RS16355

DW767_RS16350

Leader:

MRKFDRTNMKYNNPAGDLLTELEAA

Core:

DLTSNKVDSLASSGVVCTISVECGSIFTLACC

Core with dehydrations:

DLDhbDhaNKVDDhaLADhaDhaGVVCysDhbIDhaVECysGDhaIFDhbLACysCys

antiSMASH-DB 4.0 matches for DW767_RS16350

100.0%

NZ_JAQDBP010000004.1and 18 others:

Lanthipeptides: PGY07_RS07085_lanthipeptide

DLTSNKVDSLASSGVVCTISVECGSIFTLACC

62.5%

NZ_CP022413.2and 1 other:

NZ_JAQEYW010000009.1 Lanthipeptides: PG422_RS09400_lanthipeptide

Lanthipeptides: CGC63_RS01420_lanthipeptide

SGVVCTISVECGSIFTLACC

40.6%

NZ_FNUH01000004.1and 1 other:

NZ_FOGM01000011.1 Lanthipeptides: BMX20_RS07220_lanthipeptide

Lanthipeptides: BLU50_RS05815_lanthipeptide

SGVVCTISVEC-----GSIFTLACC

GVV T+S EC SIFT CC

QGVVPTVSYECRMNSWQSIFT--CC

with 122 more sequence matches

Only the first 10 are displayed here.

37.5%

NZ_AUBN01000022.1:

Lanthipeptides: G448_RS16025_lanthipeptide

ASSGVVCTISVECGSIFTLAC

ASSG CT+++ECG+ F AC

ASSGWFCTLTIECGT-FICAC

37.5%

NZ_CP061274.1and 1 other:

NZ_JADKRR010000001.1 Lanthipeptides: ITJ40_RS10085_lanthipeptide

Lanthipeptides: H9X71_RS09850_lanthipeptide

ASSGVVCTISVECGSIFTLAC

ASSG +CT+++ECG+ F AC

ASSGWLCTLTIECGT-FICAC

36.4%

NZ_CP040409.1and 4 others:

Lanthipeptides: FE336_RS08590_lanthipeptide

SSGVVCTISVECGSIFTLACC

S G CTI+ EC +FT+ACC

SCGRACTITAEC-PVFTVACC

34.4%

NZ_CP069183.1:

Lanthipeptides: LLNCDO700_RS13730_lanthipeptide

ASSGVVCTISVECG---SIFTLACC

SGV+ TIS EC F CC

GGSGVIHTISHECNMNSWQFVFTCC

34.4%

NZ_CP086242.1and 1 other:

NZ_CP086245.1 Lanthipeptides: LL037_RS25615_lanthipeptide

Lanthipeptides: LL038_RS25355_lanthipeptide

ASSGVVCTISVECGSIFTLACC

ASSG +CT + EC + F+ CC

ASSGAICTATTEC-TYFSAICC

32.4%

NZ_JADNMH010000005.1:

Lanthipeptides: I2E99_RS07105_lanthipeptide

SSGVVCTISVECGSIFTLACC

S G CTI+ EC I T+ CC

SCGRRCTITTEC-PIATVVCC

32.4%

NZ_JAESIP010000017.1and 3 others:

NZ_LT907978.1 Lanthipeptides: EHLA_RS12685_lanthipeptideNZ_QRYY01000029.1 Lanthipeptides: DWW21_RS18370_lanthipeptideNZ_SPFW01000044.1 Lanthipeptides: FGQ81_RS16590_lanthipeptide

Lanthipeptides: JMK14_RS12260_lanthipeptide

ASSGVVCTISVECGSIFTLACC

AS G +CT + EC I T+ CC

ASCGRLCTGTAEC-PIMTIICC

31.2%

NZ_AP025017.1:

Lanthipeptides: MANAM107_RS05920_lanthipeptide

SGVVCTISVECG---SIFTLACC

+GV+ TIS EC F CC

NGVITTISHECHLNTWAFAFTCC

31.2%

NZ_CP034248.1:

Lanthipeptides: EIM92_RS14995_lanthipeptide

ASSGVVCTISVEC

AS GV+CTIS EC

ASGGVICTISHEC

31.2%

NZ_CP114875.1:

Lanthipeptides: O4Z47_RS14375_lanthipeptide

SSGVVCTISVECGSIFTLACC

SSG +CT++ EC + T CC

SSGDICTLTSECDHLATWVCC

MIBiG 4.0 matches for DW767_RS16350

21.9%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

LASSGVVCTISVEC

L + G CT++VEC

LGNKGAYCTLTVEC

18.8%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

DSLASSGVVCTISVEC

++L ++G CT++ EC

NALGNNGGWCTLTKEC

12.8%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

CTISVECGS

CT+S EC

CTLSKECQP

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 24.36 out of 29.25

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.68 out of 27.78

Confidence: medium

Lanthipeptides

TFBS Finder

Core peptide predictions

DW767_RS16350 - Class II

Cleavage pHMM score: -6.00

RODEO score: 0

Monoisotopic mass: 3059.5 Da

Molecular weight: 3061.5 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3079.5 Da N = 1; 3097.5 Da N = 2; 3115.6 Da N = 3; 3133.6 Da N = 4; 3151.6 Da N = 5

DW767_RS16305 - Class II

Cleavage pHMM score: -6.40

RODEO score: 0

Monoisotopic mass: 2127.9 Da

Molecular weight: 2129.5 Da

Number of bridges: 4

DW767_RS16350 - Class II

Cleavage pHMM score: -6.00

RODEO score: 0

Monoisotopic mass: 3059.5 Da

Molecular weight: 3061.5 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3079.5 Da N = 1; 3097.5 Da N = 2; 3115.6 Da N = 3; 3133.6 Da N = 4; 3151.6 Da N = 5

allorf_092199_092297 - Class II

Cleavage pHMM score: -5.20

RODEO score: 0

Monoisotopic mass: 1761.0 Da

Molecular weight: 1762.1 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1780.1 Da N = 1

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
SypG	Regulator of biofilm formation and host colonization

NZ_QSJW01000002.1 - Region 1 - cyclic-lactone-autoinducer

Download region GenBank file

Download region SVG

Location: 391,971 - 412,703 nt. (total: 20,733 nt) Show pHMM detection rules used

Region on contig edge.

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000506.4	0.33	ribosomal	entianin	Bacillus subtilis subsp. spizizenii
BGC0000515.4	0.33	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0000752.3	0.32	saccharide	capsular polysaccharide	Actinobacillus pleuropneumoniae serovar 6 str. Femo
BGC0000527.5	0.32	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0001727.3	0.32	ribosomal	paenilan	Paenibacillus polymyxa E681
BGC0000547.5	0.31	ribosomal	salivaricin 9	Streptococcus salivarius
BGC0000559.4	0.31	ribosomal	subtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000550.3	0.30	ribosomal	salivaricin G32	Streptococcus salivarius
BGC0000188.5	0.30	other (other)	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0000310.5	0.29	NRPS	bacitracin	Bacillus licheniformis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000506.4	0.33	ribosomal	entianin	Bacillus subtilis subsp. spizizenii
BGC0000515.4	0.33	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0000752.3	0.32	saccharide	capsular polysaccharide	Actinobacillus pleuropneumoniae serovar 6 str. Femo
BGC0000527.5	0.32	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0001727.3	0.32	ribosomal	paenilan	Paenibacillus polymyxa E681
BGC0000547.5	0.31	ribosomal	salivaricin 9	Streptococcus salivarius
BGC0000559.4	0.31	ribosomal	subtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000550.3	0.30	ribosomal	salivaricin G32	Streptococcus salivarius
BGC0000188.5	0.30	other (other)	saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2	Cylindrospermopsis raciborskii T3
BGC0000310.5	0.29	NRPS	bacitracin	Bacillus licheniformis

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.96 out of 26.85

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 15.28 out of 18.16

Confidence: strong

Additional weak hits (4):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 20.08 out of 30.22

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 24.57 out of 35.63

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.88 out of 30.98

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.69 out of 29.65

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
RutR	Regulator of the pyrimidine and purine metabolism

NZ_QSJW01000007.1 - Region 1 - terpene-precursor

Download region GenBank file

Download region SVG

Location: 206,583 - 227,470 nt. (total: 20,888 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: PPTase glycosyltransferase

DW767_RS12370: glycosyl transferase group 1

smcogs: SMCOG1045: glycosyl transferase group 1

DW767_RS12480: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: back translocase

DW767_RS12435: GTP-binding protein LepA

smcogs: SMCOG1190: GTP-binding protein LepA

Ligases: synthase synthetase

DW767_RS12405: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

DW767_RS12410: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0000665.5	0.42	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0001605.3	0.40	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001594.3	0.40	other (other)	fischerindole L	Fischerella muscicola UTEX 1829
BGC0000668.5	0.39	other (other), terpene	12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole	Hapalosiphon welwitschii UTEX B 1830
BGC0001604.3	0.39	terpene	gibberellin	Fusarium fujikuroi
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0000665.5	0.42	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0001605.3	0.40	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001594.3	0.40	other (other)	fischerindole L	Fischerella muscicola UTEX 1829
BGC0000668.5	0.39	other (other), terpene	12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole	Hapalosiphon welwitschii UTEX B 1830
BGC0001604.3	0.39	terpene	gibberellin	Fusarium fujikuroi
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

DW767_RS12410: PT_FPPS_like

Domain 1 (32 - 293): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.19 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.66 out of 27.78

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.72 out of 24.78

Confidence: medium

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.15 out of 18.46

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.59 out of 23.05

Confidence: medium

Additional weak hits (3):

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 22.59 out of 30.97

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.27 out of 25.75

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.13 out of 30.25

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 2	Repressor of DNA damage response
RpoN	Regulator of nitrogen assimilation and virulence