Select genomic region:
Overview
1.1
2.1
4.1
12.1
22.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_QSJW01000001.1 (Blautia obeum)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | t3nrps-iterative | 264,683 | 307,581 |

NZ_QSJW01000010.1 (Blautia obeum)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 2.1 | ranthipeptide | 30,720 | 52,313 |

NZ_QSJW01000012.1 (Blautia obeum)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 4.1 | lanthipeptide-class-ii | 85,438 | 113,276 |  |

NZ_QSJW01000002.1 (Blautia obeum)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 12.1 | cyclic-lactone-autoinducer | 391,971 | 412,703 |

NZ_QSJW01000007.1 (Blautia obeum)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 22.1 | terpene-precursor | 206,583 | 227,470 |

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | t3nrps-iterative | 264,683 | 307,581 |
Region 2.1 | ranthipeptide | 30,720 | 52,313 |
Region 4.1 | lanthipeptide-class-ii | 85,438 | 113,276 |  |
Region 12.1 | cyclic-lactone-autoinducer | 391,971 | 412,703 |
Region 22.1 | terpene-precursor | 206,583 | 227,470 |

No secondary metabolite regions were found in these records:
  NZ_QSJW01000011.1 (Blautia obeum)
  NZ_QSJW01000013.1 (Blautia obeum)
  NZ_QSJW01000014.1 (Blautia obeum)
  NZ_QSJW01000015.1 (Blautia obeum)
  NZ_QSJW01000016.1 (Blautia obeum)
  NZ_QSJW01000017.1 (Blautia obeum)
  NZ_QSJW01000018.1 (Blautia obeum)
  NZ_QSJW01000019.1 (Blautia obeum)
  NZ_QSJW01000020.1 (Blautia obeum)
  NZ_QSJW01000021.1 (Blautia obeum)
  NZ_QSJW01000022.1 (Blautia obeum)
  NZ_QSJW01000023.1 (Blautia obeum)
  NZ_QSJW01000024.1 (Blautia obeum)
  NZ_QSJW01000003.1 (Blautia obeum)
  NZ_QSJW01000004.1 (Blautia obeum)
  NZ_QSJW01000005.1 (Blautia obeum)
  NZ_QSJW01000006.1 (Blautia obeum)
  NZ_QSJW01000008.1 (Blautia obeum)
  NZ_QSJW01000009.1 (Blautia obeum)

Compact view
NZ_QSJW01000001.1 - Region 1 - t3nrps-iterative
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 264,683 - 307,581 nt. (total: 42,899 nt) Show pHMM detection rules used
t3nrps-iterative: (AMP-binding and PP-binding and (DUF98 or Orn_Arg_deC_N or Orn_DAP_Arg_deC) and not ATP-grasp)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
DW767_RS01245: NADH:flavin oxidoreductase/NADH oxidase

smcogs
  SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

Hydrolases: hydrolase
DW767_RS01285: hydrolase

smcogs
  SMCOG1179: hydrolase

DW767_RS01365: amidohydrolase

smcogs
  SMCOG1244: amidohydrolase

Lyases: decarboxylase
DW767_RS01305: diaminopimelate decarboxylase

smcogs
  SMCOG1264: diaminopimelate decarboxylase

Ligases: ligase
DW767_RS01300: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | t3nrps-iterative | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.60 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0000307.4 |  | 0.60 | NRPS | AbT1 | Aureobasidium pullulans
BGC0001408.5 |  | 0.45 | other (other) | xanthoferrin | Xanthomonas oryzae pv. oryzae KACC 10331
BGC0000308.5 |  | 0.43 | NRPS | aureusimine A, aureusimine B, aureusimine C | Staphylococcus aureus subsp. aureus str. JKD6008
BGC0000885.3 |  | 0.42 | other (other) | 4-hydroxy-3-nitrosobenzamide | Streptomyces murayamaensis
BGC0000310.5 |  | 0.42 | NRPS | bacitracin | Bacillus licheniformis
BGC0000527.5 |  | 0.42 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0002071.2 |  | 0.42 | NRPS | virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D | Pseudomonas sp. QS1027
BGC0001733.3 |  | 0.41 | ribosomal | PcpA | Pleurocapsa sp. PCC 7327
BGC0000550.3 |  | 0.41 | ribosomal | salivaricin G32 | Streptococcus salivarius

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.60 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0000307.4 |  | 0.60 | NRPS | AbT1 | Aureobasidium pullulans
BGC0001408.5 |  | 0.45 | other (other) | xanthoferrin | Xanthomonas oryzae pv. oryzae KACC 10331
BGC0000308.5 |  | 0.43 | NRPS | aureusimine A, aureusimine B, aureusimine C | Staphylococcus aureus subsp. aureus str. JKD6008
BGC0000885.3 |  | 0.42 | other (other) | 4-hydroxy-3-nitrosobenzamide | Streptomyces murayamaensis
BGC0000310.5 |  | 0.42 | NRPS | bacitracin | Bacillus licheniformis
BGC0000527.5 |  | 0.42 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0002071.2 |  | 0.42 | NRPS | virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D | Pseudomonas sp. QS1027
BGC0001733.3 |  | 0.41 | ribosomal | PcpA | Pleurocapsa sp. PCC 7327
BGC0000550.3 |  | 0.41 | ribosomal | salivaricin G32 | Streptococcus salivarius

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 24.83 out of 27.78
Confidence: strong
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.60 out of 21.55
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.89 out of 18.16
Confidence: strong
Additional weak hits (6):
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 22.39 out of 28.14
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.42 out of 36.54
Confidence: weak
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 19.14 out of 22.40
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.45 out of 20.01
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.96 out of 31.73
Confidence: weak
NrdR
Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 20.59 out of 27.18
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS substrates
TFBS Finder
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
DW767_RS01300: X
AMP-binding (10..412): X
nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    FHFAFDVSVKDTIWFFSGEVNLYGPTEITCNCTY
  Nearest Stachelhaus code(s):
    Ser DVWHFSLVDK (59% 8Å match)
  Stachelhaus code match:
    60% (weak)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
ArcA | Repressor of carbon oxidation
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria

NZ_QSJW01000010.1 - Region 1 - ranthipeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 30,720 - 52,313 nt. (total: 21,594 nt) Show pHMM detection rules used
ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | ranthipeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002306.2 |  | 0.47 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002306.2 |  | 0.47 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.77 out of 27.78
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.53 out of 20.97
Confidence: medium
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.71 out of 20.47
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.83 out of 27.78
Confidence: medium
Additional weak hits (2):
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 23.25 out of 30.97
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.87 out of 33.14
Confidence: weak
RREFinder
TFBS Finder
RRE predictions
RREfinder results sidepanel.

ranthipeptide protocluster (30719...52313)
DW767_RS14485
  RRE type: Ranthipeptide_rSAM_RRE
  Location: 1 - 102
  Score: 92.4

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ToxT | Regulator of MSHA biosynthesis
VqsM | Regulator of quorum-sensing signalling systems

NZ_QSJW01000012.1 - Region 1 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 85,438 - 113,276 nt. (total: 27,839 nt) Show pHMM detection rules used
Region on contig edge.
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: cyclase
DW767_RS16310: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

DW767_RS16355: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000504.5 |  | 0.57 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000552.3 |  | 0.55 | ribosomal | SmbA, SmbB | Streptococcus mutans
BGC0001210.5 |  | 0.53 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000516.4 |  | 0.51 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000528.5 |  | 0.51 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000497.3 |  | 0.51 | ribosomal | BHT-Aα, BHT-Aβ | Streptococcus ratti
BGC0002110.3 |  | 0.50 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0000500.5 |  | 0.50 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0001391.3 |  | 0.50 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni
BGC0001229.4 |  | 0.50 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000504.5 |  | 0.57 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000552.3 |  | 0.55 | ribosomal | SmbA, SmbB | Streptococcus mutans
BGC0001210.5 |  | 0.53 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000516.4 |  | 0.51 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000528.5 |  | 0.51 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000497.3 |  | 0.51 | ribosomal | BHT-Aα, BHT-Aβ | Streptococcus ratti
BGC0002110.3 |  | 0.50 | ribosomal | birimositide | Streptomyces rimosus subsp. rimosus WC-3908
BGC0000500.5 |  | 0.50 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0001391.3 |  | 0.50 | ribosomal | thusin | Bacillus thuringiensis serovar rongseni
BGC0001229.4 |  | 0.50 | ribosomal | SBI-06990 A1, SBI-06989 A2 | Streptomyces bingchenggensis BCW-1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for DW767_RS16310

DW767_RS16305
Leader:
MKKNYRNPMTRPENFMNPAGNVMKEIKEADLNNFSAGAGEPRVSDGS
Core:
Q F C T S T K E C N W G T I M F V C C
Core with dehydrations:
Q F Cys Dhb Dha Dhb K E Cys N W G Dhb I M F V Cys Cys

#### antiSMASH-DB 4.0 matches for DW767_RS16305

100.0%
NZ_CP102267.1 and 11 others:
NZ_FMUW01000051.1 Lanthipeptides: BLP57_RS16830_lanthipeptide NZ_JAQDBP010000004.1 Lanthipeptides: PGY07_RS07130_lanthipeptide NZ_JAQEHQ010000024.1 Lanthipeptides: PGR68_RS13915_lanthipeptide NZ_JAQESL010000043.1 Lanthipeptides: PG840_RS15980_lanthipeptide NZ_JAQESS010000001.1 Lanthipeptides: PG808_RS00050_lanthipeptide NZ_LN913006.1 Lanthipeptides: BN3261_RS01470_lanthipeptide NZ_QRPQ01000011.1 Lanthipeptides: DWZ74_RS14610_lanthipeptide NZ_QRZZ01000003.1 Lanthipeptides: DWV87_RS03120_lanthipeptide NZ_QSJW01000012.1 Lanthipeptides: DW767_RS16305_lanthipeptide NZ_QSKF01000004.1 Lanthipeptides: DW740_RS06255_lanthipeptide NZ_QUJJ01000004.1 Lanthipeptides: DW748_RS03580_lanthipeptide
Lanthipeptides: NQ550_RS04155_lanthipeptide
1
Q F C T S T K E C N W G T I M F V C C
19
Q F C T S T K E C N W G T I M F V C C
1
Q F C T S T K E C N W G T I M F V C C
19
42.9%
NZ_QRHZ01000008.1 and 2 others:
NZ_QSRF01000021.1 Lanthipeptides: DXC87_RS15310_lanthipeptide NZ_QUEQ01000033.1 Lanthipeptides: DXA48_RS19000_lanthipeptide
Lanthipeptides: DW272_RS13830_lanthipeptide
2
F C T S T K E C N W G T I M F V C C
19
F C T S T E C N G T+ C C
11
F C T S T G E C N M G T L N I F C C
28
40.0%
NZ_JAFCGV010000005.1:
Lanthipeptides: JQI09_RS04275_lanthipeptide
4
T S T K E C N W G T I M F V C C
19
T+T E C G T F V C C
7
T A T S E C Y L G T F A F V C C
22
with 18 more sequence matches
Only the first 10 are displayed here.
40.0%
NZ_WBPF01000002.1:
Lanthipeptides: F8162_RS00195_lanthipeptide
1
Q F C T S T K E C N W G T--I M F V C C
19
Q F T + E C+W T +F C C
4
Q F D T I S H E C H W N T W Q F L F T C C
24
36.0%
NZ_CP045267.1 and 1 other:
NZ_CP045267.1 Lanthipeptides: FDZ14_RS00155_lanthipeptide
Lanthipeptides: FDZ14_RS00155_lanthipeptide
4
T S T K E C N W G T I M F V C C
19
T+T E C G T F C C
7
T A T S E C Y L G T F A F A C C
22
34.6%
NZ_CP117876.1:
Lanthipeptides: PQ460_RS01735_lanthipeptide
4
T S T K E C N W G T I M F V C C
19
T+T E C G T+ F+C C
7
T A T S E C Y L G T V A F I C C
22
33.3%
NZ_CYXV01000003.1:
Lanthipeptides: ARB75_RS04585_lanthipeptide
3
C T S T K E C N W G T I M F V C C
19
C T T E C N G T + C C
12
C T L T G E C N I G T H I K F C C
28
29.2%
NC_012470.1 and 42 others:
NZ_CAAHGW010000010.1 Lanthipeptides: E9435_RS08895_lanthipeptide NZ_CAAHHE010000002.1 Lanthipeptides: E9499_RS02930_lanthipeptide NZ_CAAHHF010000009.1 Lanthipeptides: E9478_RS08675_lanthipeptide NZ_CAAHHN010000003.1 Lanthipeptides: E9502_RS05705_lanthipeptide NZ_CAAHHU010000009.1 Lanthipeptides: E9510_RS08735_lanthipeptide NZ_CAAHHW010000012.1 Lanthipeptides: E9525_RS08985_lanthipeptide NZ_CAAHIB010000001.1 Lanthipeptides: E9539_RS01075_lanthipeptide NZ_CAAHIV010000024.1 Lanthipeptides: E9612_RS09255_lanthipeptide NZ_CAAHKK010000019.1 Lanthipeptides: E9649_RS08770_lanthipeptide NZ_CAAHKP010000014.1 Lanthipeptides: E9652_RS08920_lanthipeptide NZ_CAAHKQ010000003.1 Lanthipeptides: E9664_RS02160_lanthipeptide NZ_CAAHKY010000014.1 Lanthipeptides: E9668_RS09650_lanthipeptide NZ_CAAHLP010000002.1 Lanthipeptides: E9684_RS03445_lanthipeptide NZ_CAAHQE010000012.1 Lanthipeptides: E9931_RS08815_lanthipeptide NZ_CAAHRY010000002.1 Lanthipeptides: E9986_RS03175_lanthipeptide NZ_CAAIES010000002.1 Lanthipeptides: FAH15_RS02475_lanthipeptide NZ_CAAIIA010000012.1 Lanthipeptides: FAH55_RS08475_lanthipeptide NZ_CAAIJM010000015.1 Lanthipeptides: FAI23_RS09585_lanthipeptide NZ_CAAINV010000013.1 Lanthipeptides: FAI86_RS09025_lanthipeptide NZ_CAAIRS010000012.1 Lanthipeptides: FAK24_RS08485_lanthipeptide NZ_CAAJFI010000013.1 Lanthipeptides: FAP60_RS08495_lanthipeptide NZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS10120_lanthipeptide NZ_CP018188.1 Lanthipeptides: BSR19_RS11185_lanthipeptide NZ_CP029398.1 Lanthipeptides: DF184_RS05190_lanthipeptide NZ_CP035426.1 Lanthipeptides: ETT73_RS02600_lanthipeptide NZ_CP035437.1 Lanthipeptides: ETT62_RS06670_lanthipeptide NZ_CP035443.1 Lanthipeptides: ETT56_RS07260_lanthipeptide NZ_CP066093.1 Lanthipeptides: I6I02_RS07305_lanthipeptide NZ_CP078012.1 Lanthipeptides: KV238_RS09825_lanthipeptide NZ_JAFLMI010000009.1 Lanthipeptides: J0638_RS05340_lanthipeptide NZ_JALDUD010000010.1 Lanthipeptides: M1G10_RS09695_lanthipeptide NZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09305_lanthipeptide NZ_JAQDVH010000019.1 Lanthipeptides: PGU04_RS09305_lanthipeptide NZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06590_lanthipeptide NZ_JAQMJT010000006.1 Lanthipeptides: PNU26_RS06590_lanthipeptide NZ_KV832031.1 Lanthipeptides: HMPREF2637_RS10860_lanthipeptide NZ_LR738724.1 Lanthipeptides: GPW69_RS05070_lanthipeptide NZ_LS483425.1 Lanthipeptides: DQN36_RS06745_lanthipeptide NZ_NWMU01000024.1 Lanthipeptides: CO197_RS09155_lanthipeptide NZ_PKIA01000004.1 Lanthipeptides: CYK22_RS04325_lanthipeptide NZ_VMMF01000004.1 Lanthipeptides: HT717_RS01580_lanthipeptide NZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05570_lanthipeptide
Lanthipeptides: SZO_RS10260_lanthipeptide
4
T S T K E C N W G T I--M F V C C
19
T + E C W ++ +F C C
7
T I S A E C R W N S L Q A I F T C C
24
29.2%
NZ_ALSD01000046.1 and 5 others:
NZ_CAJHJS010000009.1 Lanthipeptides: JMX87_RS06795_lanthipeptide NZ_CM001076.1 Lanthipeptides: SDD27957_RS10995_lanthipeptide NZ_GL636070.1 Lanthipeptides: HMPREF9171_RS1000000113590_lanthipeptide NZ_LR793258.1 Lanthipeptides: HV369_RS03150_lanthipeptide NZ_LT545678.1 Lanthipeptides: BJR96_RS11590_lanthipeptide
Lanthipeptides: SAG0161_RS1000000124770_lanthipeptide
4
T S T K E C N W G T I--M F V C C
19
T + E C W ++ +F C C
7
T I S A E C R W N S L Q A I F S C C
24
27.6%
NZ_CP034118.1 and 1 other:
NZ_CP034118.1 Lanthipeptides: EG886_RS06310_lanthipeptide
Lanthipeptides: EG886_RS06310_lanthipeptide
1
Q F C T S T K E C
9
Q F C T T K E C
15
Q F C T L T K E C
23
26.3%
NZ_CP059557.1:
Lanthipeptides: H2Q94_RS19875_lanthipeptide
7
K E C N W G T I M F V C
18
+ C+W G + V C
3
Q S C S W G P V T A V C
14
25.0%
NC_021362.1 and 29 others:
NC_021362.1 Lanthipeptides: BALI_RS00925_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptide NZ_AP025342.1 Lanthipeptides: L6430_RS07485_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptide NZ_CABJBE010000012.1 Lanthipeptides: FY264_RS20080_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptide NZ_CP010524.1 Lanthipeptides: SC10_RS00925_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptide NZ_CP020352.1 Lanthipeptides: BLMD_RS01020_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptide NZ_CP023168.1 Lanthipeptides: CK945_RS01020_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptide NZ_CP118744.1 Lanthipeptides: PWG69_RS01020_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptide NZ_JAHHXA010000013.1 Lanthipeptides: KM899_RS20280_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptide NZ_KN125579.1 Lanthipeptides: DJ88_RS03675_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptide NZ_NIKL01000035.1 Lanthipeptides: CHCC20347_RS19035_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptide NZ_NIKT01000033.1 Lanthipeptides: CHCC20333_RS16145_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptide NZ_NILF01000041.1 Lanthipeptides: CHCC15381_RS11915_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptide NZ_NIMP01000010.1 Lanthipeptides: CHCC14566_RS01520_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptide NZ_NKBC01000001.1 Lanthipeptides: CE036_RS00060_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptide NZ_QXII01000007.1 Lanthipeptides: D1791_RS21800_lanthipeptide
Lanthipeptides: BALI_RS00925_lanthipeptide
1
Q F C T S T K E C
9
Q+C T T K E C
15
Q W C T L T K E C
23
24.1%
NZ_CP034118.1 and 1 other:
NZ_CP034118.1 Lanthipeptides: EG886_RS06305_lanthipeptide
Lanthipeptides: EG886_RS06305_lanthipeptide
1
Q F C T S T K E C
9
+F C T T K E C
15
R F C T L T K E C
23

#### MIBiG 4.0 matches for DW767_RS16305

26.3%
BGC0000503.5 (cinA):
Lanthipeptide: cinnamycin
7
K E C N W G T I M F V C
18
+ C++G F V C
3
Q S C S F G P F T F V C
14
20.0%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
2
F C T S T K E C
9
+C T T K E C
18
W C T L T K E C
25
17.9%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
2
F C T S T K E C
9
+C T T E C
16
Y C T L T V E C
23
with 3 more sequence matches
13.6%
BGC0000553.3 (SSGG_RS09925):
Lanthipeptide: SRO15-2212
9
C N W G T I M F V C C
19
C + ++ V C
10
C E Y S S L S V V L C
20
12.8%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
3
C T S T K E C
9
C T +K E C
28
C T L S K E C
34
10.8%
BGC0001229.4 (SBI_06989)and 1 other:
BGC0002110.3 (QKV49894.1) Lanthipeptide: birimositide
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
2
F C T S T K
7
F C +T K
27
F C P T T K
32
DW767_RS16350
Leader:
MRKFDRTNMKYNNPAGDLLTELEAA
Core:
D L T S N K V D S L A S S G V V C T I S V E C G S I F T L A C C
Core with dehydrations:
D L Dhb Dha N K V D Dha L A Dha Dha G V V Cys Dhb I Dha V E Cys G Dha I F Dhb L A Cys Cys

#### antiSMASH-DB 4.0 matches for DW767_RS16350

100.0%
NZ_JAQDBP010000004.1 and 18 others:
NZ_JAQDBP010000004.1 Lanthipeptides: PGY07_RS07085_lanthipeptide NZ_JAQEAL010000002.1 Lanthipeptides: PGU65_RS02165_lanthipeptide NZ_JAQESL010000010.1 Lanthipeptides: PG840_RS09145_lanthipeptide NZ_JAQEUC010000007.1 Lanthipeptides: PG788_RS06860_lanthipeptide NZ_QRHW01000005.1 Lanthipeptides: DW641_RS05035_lanthipeptide NZ_QROS01000011.1 Lanthipeptides: DW021_RS13630_lanthipeptide NZ_QRPQ01000001.1 Lanthipeptides: DWZ74_RS02490_lanthipeptide NZ_QRZZ01000003.1 Lanthipeptides: DWV87_RS03165_lanthipeptide NZ_QRZZ01000003.1 Lanthipeptides: DWV87_RS03165_lanthipeptide NZ_QSJW01000012.1 Lanthipeptides: DW767_RS16350_lanthipeptide NZ_QSJW01000012.1 Lanthipeptides: DW767_RS16350_lanthipeptide NZ_QSKF01000004.1 Lanthipeptides: DW740_RS06305_lanthipeptide NZ_QSKF01000004.1 Lanthipeptides: DW740_RS06305_lanthipeptide NZ_QTZB01000014.1 Lanthipeptides: DXC15_RS13895_lanthipeptide NZ_QUCI01000011.1 Lanthipeptides: DW648_RS10830_lanthipeptide NZ_QUJJ01000004.1 Lanthipeptides: DW748_RS03630_lanthipeptide NZ_QUJJ01000004.1 Lanthipeptides: DW748_RS03630_lanthipeptide NZ_QUKU01000006.1 Lanthipeptides: DXC27_RS05470_lanthipeptide
Lanthipeptides: PGY07_RS07085_lanthipeptide
1
D L T S N K V D S L A S S G V V C T I S V E C G S I F T L A C C
32
D L T S N K V D S L A S S G V V C T I S V E C G S I F T L A C C
1
D L T S N K V D S L A S S G V V C T I S V E C G S I F T L A C C
32
62.5%
NZ_CP022413.2 and 1 other:
NZ_JAQEYW010000009.1 Lanthipeptides: PG422_RS09400_lanthipeptide
Lanthipeptides: CGC63_RS01420_lanthipeptide
13
S G V V C T I S V E C G S I F T L A C C
32
S G V V C T I S V E C G S I F T L A C C
1
S G V V C T I S V E C G S I F T L A C C
20
40.6%
NZ_FNUH01000004.1 and 1 other:
NZ_FOGM01000011.1 Lanthipeptides: BMX20_RS07220_lanthipeptide
Lanthipeptides: BLU50_RS05815_lanthipeptide
13
S G V V C T I S V E C-----G S I F T L A C C
32
G V V T+S E C S I F T C C
5
Q G V V P T V S Y E C R M N S W Q S I F T--C C
27
with 122 more sequence matches
Only the first 10 are displayed here.
37.5%
NZ_AUBN01000022.1:
Lanthipeptides: G448_RS16025_lanthipeptide
11
A S S G V V C T I S V E C G S I F T L A C
31
A S S G C T+++E C G+ F A C
1
A S S G W F C T L T I E C G T-F I C A C
20
37.5%
NZ_CP061274.1 and 1 other:
NZ_JADKRR010000001.1 Lanthipeptides: ITJ40_RS10085_lanthipeptide
Lanthipeptides: H9X71_RS09850_lanthipeptide
11
A S S G V V C T I S V E C G S I F T L A C
31
A S S G +C T+++E C G+ F A C
1
A S S G W L C T L T I E C G T-F I C A C
20
36.4%
NZ_CP040409.1 and 4 others:
NZ_CP040411.1 Lanthipeptides: FE334_RS06825_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS09430_lanthipeptide NZ_JH601103.1 Lanthipeptides: HMPREF9703_RS02710_lanthipeptide NZ_NAQX01000046.1 Lanthipeptides: B8A46_RS06295_lanthipeptide
Lanthipeptides: FE336_RS08590_lanthipeptide
12
S S G V V C T I S V E C G S I F T L A C C
32
S G C T I+ E C +F T+A C C
14
S C G R A C T I T A E C-P V F T V A C C
33
34.4%
NZ_CP069183.1:
Lanthipeptides: LLNCDO700_RS13730_lanthipeptide
11
A S S G V V C T I S V E C G---S I F T L A C C
32
S G V+ T I S E C F C C
2
G G S G V I H T I S H E C N M N S W Q F V F T C C
26
34.4%
NZ_CP086242.1 and 1 other:
NZ_CP086245.1 Lanthipeptides: LL037_RS25615_lanthipeptide
Lanthipeptides: LL038_RS25355_lanthipeptide
11
A S S G V V C T I S V E C G S I F T L A C C
32
A S S G +C T + E C + F+ C C
1
A S S G A I C T A T T E C-T Y F S A I C C
21
32.4%
NZ_JADNMH010000005.1:
Lanthipeptides: I2E99_RS07105_lanthipeptide
12
S S G V V C T I S V E C G S I F T L A C C
32
S G C T I+ E C I T+ C C
15
S C G R R C T I T T E C-P I A T V V C C
34
32.4%
NZ_JAESIP010000017.1 and 3 others:
NZ_LT907978.1 Lanthipeptides: EHLA_RS12685_lanthipeptide NZ_QRYY01000029.1 Lanthipeptides: DWW21_RS18370_lanthipeptide NZ_SPFW01000044.1 Lanthipeptides: FGQ81_RS16590_lanthipeptide
Lanthipeptides: JMK14_RS12260_lanthipeptide
11
A S S G V V C T I S V E C G S I F T L A C C
32
A S G +C T + E C I T+ C C
14
A S C G R L C T G T A E C-P I M T I I C C
34
31.2%
NZ_AP025017.1:
Lanthipeptides: MANAM107_RS05920_lanthipeptide
13
S G V V C T I S V E C G---S I F T L A C C
32
+G V+ T I S E C F C C
1
N G V I T T I S H E C H L N T W A F A F T C C
23
31.2%
NZ_CP034248.1:
Lanthipeptides: EIM92_RS14995_lanthipeptide
11
A S S G V V C T I S V E C
23
A S G V+C T I S E C
5
A S G G V I C T I S H E C
17
31.2%
NZ_CP114875.1:
Lanthipeptides: O4Z47_RS14375_lanthipeptide
12
S S G V V C T I S V E C G S I F T L A C C
32
S S G +C T++ E C + T C C
7
S S G D I C T L T S E C D H L A T W V C C
27

#### MIBiG 4.0 matches for DW767_RS16350

21.9%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
10
L A S S G V V C T I S V E C
23
L + G C T++V E C
10
L G N K G A Y C T L T V E C
23
18.8%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
8
D S L A S S G V V C T I S V E C
23
++L ++G C T++ E C
10
N A L G N N G G W C T L T K E C
25
12.8%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
17
C T I S V E C G S
25
C T+S E C
28
C T L S K E C Q P
36
allorf_092199_092297
Leader:
MIRSSIIFFVLNKLQGS
Core:
C Q V S V R F L S E K Y I I L
Core with dehydrations:
Cys Q V Dha V R F L Dha E K Y I I L

#### antiSMASH-DB 4.0 matches for allorf_092199_092297

100.0%
NZ_CP102267.1 and 7 others:
NZ_JAQDBP010000004.1 Lanthipeptides: allorf_177044_177142_lanthipeptide NZ_JAQEHQ010000024.1 Lanthipeptides: allorf_20164_20253_lanthipeptide NZ_JAQESL010000043.1 Lanthipeptides: allorf_02084_02182_lanthipeptide NZ_JAQESS010000001.1 Lanthipeptides: allorf_017059_017148_lanthipeptide NZ_LN913006.1 Lanthipeptides: allorf_0097924_0098022_lanthipeptide NZ_QRPQ01000011.1 Lanthipeptides: allorf_103379_103477_lanthipeptide NZ_QSJW01000012.1 Lanthipeptides: allorf_092199_092297_lanthipeptide
Lanthipeptides: allorf_0889319_0889417_lanthipeptide
1
C Q V S V R F L S E K Y I I L
15
C Q V S V R F L S E K Y I I L
1
C Q V S V R F L S E K Y I I L
15

#### Lanthipeptide(s) for DW767_RS16355

DW767_RS16350
Leader:
MRKFDRTNMKYNNPAGDLLTELEAA
Core:
D L T S N K V D S L A S S G V V C T I S V E C G S I F T L A C C
Core with dehydrations:
D L Dhb Dha N K V D Dha L A Dha Dha G V V Cys Dhb I Dha V E Cys G Dha I F Dhb L A Cys Cys

#### antiSMASH-DB 4.0 matches for DW767_RS16350

100.0%
NZ_JAQDBP010000004.1 and 18 others:
NZ_JAQDBP010000004.1 Lanthipeptides: PGY07_RS07085_lanthipeptide NZ_JAQEAL010000002.1 Lanthipeptides: PGU65_RS02165_lanthipeptide NZ_JAQESL010000010.1 Lanthipeptides: PG840_RS09145_lanthipeptide NZ_JAQEUC010000007.1 Lanthipeptides: PG788_RS06860_lanthipeptide NZ_QRHW01000005.1 Lanthipeptides: DW641_RS05035_lanthipeptide NZ_QROS01000011.1 Lanthipeptides: DW021_RS13630_lanthipeptide NZ_QRPQ01000001.1 Lanthipeptides: DWZ74_RS02490_lanthipeptide NZ_QRZZ01000003.1 Lanthipeptides: DWV87_RS03165_lanthipeptide NZ_QRZZ01000003.1 Lanthipeptides: DWV87_RS03165_lanthipeptide NZ_QSJW01000012.1 Lanthipeptides: DW767_RS16350_lanthipeptide NZ_QSJW01000012.1 Lanthipeptides: DW767_RS16350_lanthipeptide NZ_QSKF01000004.1 Lanthipeptides: DW740_RS06305_lanthipeptide NZ_QSKF01000004.1 Lanthipeptides: DW740_RS06305_lanthipeptide NZ_QTZB01000014.1 Lanthipeptides: DXC15_RS13895_lanthipeptide NZ_QUCI01000011.1 Lanthipeptides: DW648_RS10830_lanthipeptide NZ_QUJJ01000004.1 Lanthipeptides: DW748_RS03630_lanthipeptide NZ_QUJJ01000004.1 Lanthipeptides: DW748_RS03630_lanthipeptide NZ_QUKU01000006.1 Lanthipeptides: DXC27_RS05470_lanthipeptide
Lanthipeptides: PGY07_RS07085_lanthipeptide
1
D L T S N K V D S L A S S G V V C T I S V E C G S I F T L A C C
32
D L T S N K V D S L A S S G V V C T I S V E C G S I F T L A C C
1
D L T S N K V D S L A S S G V V C T I S V E C G S I F T L A C C
32
62.5%
NZ_CP022413.2 and 1 other:
NZ_JAQEYW010000009.1 Lanthipeptides: PG422_RS09400_lanthipeptide
Lanthipeptides: CGC63_RS01420_lanthipeptide
13
S G V V C T I S V E C G S I F T L A C C
32
S G V V C T I S V E C G S I F T L A C C
1
S G V V C T I S V E C G S I F T L A C C
20
40.6%
NZ_FNUH01000004.1 and 1 other:
NZ_FOGM01000011.1 Lanthipeptides: BMX20_RS07220_lanthipeptide
Lanthipeptides: BLU50_RS05815_lanthipeptide
13
S G V V C T I S V E C-----G S I F T L A C C
32
G V V T+S E C S I F T C C
5
Q G V V P T V S Y E C R M N S W Q S I F T--C C
27
with 122 more sequence matches
Only the first 10 are displayed here.
37.5%
NZ_AUBN01000022.1:
Lanthipeptides: G448_RS16025_lanthipeptide
11
A S S G V V C T I S V E C G S I F T L A C
31
A S S G C T+++E C G+ F A C
1
A S S G W F C T L T I E C G T-F I C A C
20
37.5%
NZ_CP061274.1 and 1 other:
NZ_JADKRR010000001.1 Lanthipeptides: ITJ40_RS10085_lanthipeptide
Lanthipeptides: H9X71_RS09850_lanthipeptide
11
A S S G V V C T I S V E C G S I F T L A C
31
A S S G +C T+++E C G+ F A C
1
A S S G W L C T L T I E C G T-F I C A C
20
36.4%
NZ_CP040409.1 and 4 others:
NZ_CP040411.1 Lanthipeptides: FE334_RS06825_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS09430_lanthipeptide NZ_JH601103.1 Lanthipeptides: HMPREF9703_RS02710_lanthipeptide NZ_NAQX01000046.1 Lanthipeptides: B8A46_RS06295_lanthipeptide
Lanthipeptides: FE336_RS08590_lanthipeptide
12
S S G V V C T I S V E C G S I F T L A C C
32
S G C T I+ E C +F T+A C C
14
S C G R A C T I T A E C-P V F T V A C C
33
34.4%
NZ_CP069183.1:
Lanthipeptides: LLNCDO700_RS13730_lanthipeptide
11
A S S G V V C T I S V E C G---S I F T L A C C
32
S G V+ T I S E C F C C
2
G G S G V I H T I S H E C N M N S W Q F V F T C C
26
34.4%
NZ_CP086242.1 and 1 other:
NZ_CP086245.1 Lanthipeptides: LL037_RS25615_lanthipeptide
Lanthipeptides: LL038_RS25355_lanthipeptide
11
A S S G V V C T I S V E C G S I F T L A C C
32
A S S G +C T + E C + F+ C C
1
A S S G A I C T A T T E C-T Y F S A I C C
21
32.4%
NZ_JADNMH010000005.1:
Lanthipeptides: I2E99_RS07105_lanthipeptide
12
S S G V V C T I S V E C G S I F T L A C C
32
S G C T I+ E C I T+ C C
15
S C G R R C T I T T E C-P I A T V V C C
34
32.4%
NZ_JAESIP010000017.1 and 3 others:
NZ_LT907978.1 Lanthipeptides: EHLA_RS12685_lanthipeptide NZ_QRYY01000029.1 Lanthipeptides: DWW21_RS18370_lanthipeptide NZ_SPFW01000044.1 Lanthipeptides: FGQ81_RS16590_lanthipeptide
Lanthipeptides: JMK14_RS12260_lanthipeptide
11
A S S G V V C T I S V E C G S I F T L A C C
32
A S G +C T + E C I T+ C C
14
A S C G R L C T G T A E C-P I M T I I C C
34
31.2%
NZ_AP025017.1:
Lanthipeptides: MANAM107_RS05920_lanthipeptide
13
S G V V C T I S V E C G---S I F T L A C C
32
+G V+ T I S E C F C C
1
N G V I T T I S H E C H L N T W A F A F T C C
23
31.2%
NZ_CP034248.1:
Lanthipeptides: EIM92_RS14995_lanthipeptide
11
A S S G V V C T I S V E C
23
A S G V+C T I S E C
5
A S G G V I C T I S H E C
17
31.2%
NZ_CP114875.1:
Lanthipeptides: O4Z47_RS14375_lanthipeptide
12
S S G V V C T I S V E C G S I F T L A C C
32
S S G +C T++ E C + T C C
7
S S G D I C T L T S E C D H L A T W V C C
27

#### MIBiG 4.0 matches for DW767_RS16350

21.9%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
10
L A S S G V V C T I S V E C
23
L + G C T++V E C
10
L G N K G A Y C T L T V E C
23
18.8%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
8
D S L A S S G V V C T I S V E C
23
++L ++G C T++ E C
10
N A L G N N G G W C T L T K E C
25
12.8%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
17
C T I S V E C G S
25
C T+S E C
28
C T L S K E C Q P
36

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 24.36 out of 29.25
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.68 out of 27.78
Confidence: medium
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

DW767_RS16350 - Class II
  Cleavage pHMM score: -6.00
  RODEO score: 0
  Monoisotopic mass: 3059.5 Da
  Molecular weight: 3061.5 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3079.5 Da N = 1
    3097.5 Da N = 2
    3115.6 Da N = 3
    3133.6 Da N = 4
    3151.6 Da N = 5
DW767_RS16305 - Class II
  Cleavage pHMM score: -6.40
  RODEO score: 0
  Monoisotopic mass: 2127.9 Da
  Molecular weight: 2129.5 Da
  Number of bridges: 4
DW767_RS16350 - Class II
  Cleavage pHMM score: -6.00
  RODEO score: 0
  Monoisotopic mass: 3059.5 Da
  Molecular weight: 3061.5 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3079.5 Da N = 1
    3097.5 Da N = 2
    3115.6 Da N = 3
    3133.6 Da N = 4
    3151.6 Da N = 5
allorf_092199_092297 - Class II
  Cleavage pHMM score: -5.20
  RODEO score: 0
  Monoisotopic mass: 1761.0 Da
  Molecular weight: 1762.1 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1780.1 Da N = 1

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
SypG | Regulator of biofilm formation and host colonization

NZ_QSJW01000002.1 - Region 1 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 391,971 - 412,703 nt. (total: 20,733 nt) Show pHMM detection rules used
Region on contig edge.
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000506.4 |  | 0.33 | ribosomal | entianin | Bacillus subtilis subsp. spizizenii
BGC0000515.4 |  | 0.33 | ribosomal | geobacillin I | Geobacillus thermodenitrificans NG80-2
BGC0000752.3 |  | 0.32 | saccharide | capsular polysaccharide | Actinobacillus pleuropneumoniae serovar 6 str. Femo
BGC0000527.5 |  | 0.32 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0001727.3 |  | 0.32 | ribosomal | paenilan | Paenibacillus polymyxa E681
BGC0000547.5 |  | 0.31 | ribosomal | salivaricin 9 | Streptococcus salivarius
BGC0000559.4 |  | 0.31 | ribosomal | subtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000550.3 |  | 0.30 | ribosomal | salivaricin G32 | Streptococcus salivarius
BGC0000188.5 |  | 0.30 | other (other) | saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2 | Cylindrospermopsis raciborskii T3
BGC0000310.5 |  | 0.29 | NRPS | bacitracin | Bacillus licheniformis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000506.4 |  | 0.33 | ribosomal | entianin | Bacillus subtilis subsp. spizizenii
BGC0000515.4 |  | 0.33 | ribosomal | geobacillin I | Geobacillus thermodenitrificans NG80-2
BGC0000752.3 |  | 0.32 | saccharide | capsular polysaccharide | Actinobacillus pleuropneumoniae serovar 6 str. Femo
BGC0000527.5 |  | 0.32 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0001727.3 |  | 0.32 | ribosomal | paenilan | Paenibacillus polymyxa E681
BGC0000547.5 |  | 0.31 | ribosomal | salivaricin 9 | Streptococcus salivarius
BGC0000559.4 |  | 0.31 | ribosomal | subtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000550.3 |  | 0.30 | ribosomal | salivaricin G32 | Streptococcus salivarius
BGC0000188.5 |  | 0.30 | other (other) | saxitoxin, neosaxitoxin, decarbamoylsaxitoxin, gonyautoxin 3, gonyautoxin 2 | Cylindrospermopsis raciborskii T3
BGC0000310.5 |  | 0.29 | NRPS | bacitracin | Bacillus licheniformis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.96 out of 26.85
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 15.28 out of 18.16
Confidence: strong
Additional weak hits (4):
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 20.08 out of 30.22
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 24.57 out of 35.63
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.88 out of 30.98
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.69 out of 29.65
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
RutR | Regulator of the pyrimidine and purine metabolism

NZ_QSJW01000007.1 - Region 1 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 206,583 - 227,470 nt. (total: 20,888 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: PPTase glycosyltransferase
DW767_RS12370: glycosyl transferase group 1

smcogs
  SMCOG1045: glycosyl transferase group 1

DW767_RS12480: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: back translocase
DW767_RS12435: GTP-binding protein LepA

smcogs
  SMCOG1190: GTP-binding protein LepA

Ligases: synthase synthetase
DW767_RS12405: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

DW767_RS12410: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0000665.5 |  | 0.42 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0001605.3 |  | 0.40 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0001594.3 |  | 0.40 | other (other) | fischerindole L | Fischerella muscicola UTEX 1829
BGC0000668.5 |  | 0.39 | other (other), terpene | 12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole | Hapalosiphon welwitschii UTEX B 1830
BGC0001604.3 |  | 0.39 | terpene | gibberellin | Fusarium fujikuroi
BGC0002398.2 |  | 0.38 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0000665.5 |  | 0.42 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0001605.3 |  | 0.40 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0001594.3 |  | 0.40 | other (other) | fischerindole L | Fischerella muscicola UTEX 1829
BGC0000668.5 |  | 0.39 | other (other), terpene | 12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole | Hapalosiphon welwitschii UTEX B 1830
BGC0001604.3 |  | 0.39 | terpene | gibberellin | Fusarium fujikuroi
BGC0002398.2 |  | 0.38 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
DW767_RS12410: PT_FPPS_like
Domain 1 (32 - 293): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  DMAPP, IPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.19 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.66 out of 27.78
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.72 out of 24.78
Confidence: medium
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.15 out of 18.46
Confidence: medium
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.59 out of 23.05
Confidence: medium
Additional weak hits (3):
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 22.59 out of 30.97
Confidence: weak
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.27 out of 25.75
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.13 out of 30.25
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsR | Pleiotropic regulatory for antibiotic production
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 2 | Repressor of DNA damage response
RpoN | Regulator of nitrogen assimilation and virulence