GCF_002998885.1 - 18 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_PVRO01000009.1 (Bacillus velezensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	terpene-precursor,NRP-metallophore,NRPS,RiPP-like	51,524	116,845	High	bacillibactin	NRPS:Type I

NZ_PVRO01000010.1 (Bacillus velezensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 2.1	terpene	48,427	70,310

NZ_PVRO01000011.1 (Bacillus velezensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 3.1	NRPS	1	22,631	Low	plipastatin	NRPS:Type I

NZ_PVRO01000014.1 (Bacillus velezensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 6.1	NRPS	33,215	59,442	Low	surfactin	NRPS:Type I

NZ_PVRO01000017.1 (Bacillus velezensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 9.1	NRPS	1	22,575	Low	fengycin	NRPS:Type I

NZ_PVRO01000001.1 (Bacillus velezensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 10.1	other	324,275	365,693	High	bacilysin	other:other

NZ_PVRO01000020.1 (Bacillus velezensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 13.1	NRPS	1	10,485

NZ_PVRO01000002.1 (Bacillus velezensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 21.1	transAT-PKS	90,832	179,062	High	macrolactin H	PKS
Region 21.2	lanthipeptide-class-ii	330,632	359,521
Region 21.3	terpene	524,118	544,858
Region 21.4	PKS-like	627,553	668,797

NZ_PVRO01000003.1 (Bacillus velezensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 23.1	terpene-precursor	135,474	156,364
Region 23.2	transAT-PKS	179,680	261,187	High	difficidin	PKS

NZ_PVRO01000005.1 (Bacillus velezensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 25.1	transAT-PKS-like,NRPS	1	60,230	Low	bacillaene	NRPS:Type I+PKS:Type I
Region 25.2	NRPS,transAT-PKS,betalactone	115,278	203,088	High	fengycin	NRPS:Type I

NZ_PVRO01000006.1 (Bacillus velezensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 26.1	NRPS	1	28,131	Low	surfactin	NRPS:Type I
Region 26.2	azole-containing-RiPP	39,485	69,221

NZ_PVRO01000008.1 (Bacillus velezensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 28.1	transAT-PKS,T3PKS	1	28,400	High	bacillaene	NRPS:Type I+PKS:Type I

No secondary metabolite regions were found in these records:: NZ_PVRO01000012.1 (Bacillus velezensis); NZ_PVRO01000013.1 (Bacillus velezensis); NZ_PVRO01000015.1 (Bacillus velezensis); NZ_PVRO01000016.1 (Bacillus velezensis); NZ_PVRO01000018.1 (Bacillus velezensis); NZ_PVRO01000019.1 (Bacillus velezensis); NZ_PVRO01000021.1 (Bacillus velezensis); NZ_PVRO01000022.1 (Bacillus velezensis); NZ_PVRO01000023.1 (Bacillus velezensis); NZ_PVRO01000024.1 (Bacillus velezensis); NZ_PVRO01000025.1 (Bacillus velezensis); NZ_PVRO01000026.1 (Bacillus velezensis); NZ_PVRO01000027.1 (Bacillus velezensis); NZ_PVRO01000028.1 (Bacillus velezensis); NZ_PVRO01000004.1 (Bacillus velezensis); NZ_PVRO01000007.1 (Bacillus velezensis)

Compact view

NZ_PVRO01000009.1 - Region 1 - NRP-metallophore,NRPS,RiPP-like,terpene-precursor

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Location: 51,524 - 116,845 nt. (total: 65,322 nt) Show pHMM detection rules used

Region on contig edge.

terpene-precursor: (PT_FPPS_like and not PT_HPP)
NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase reductase

C6354_RS15365: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

C6354_RS15440: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

C6354_RS15490: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

C6354_RS15500: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

C6354_RS15545: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acetyltransferase

C6354_RS15540: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

Hydrolases: esterase hydrolase

C6354_RS15280: thioesterase superfamily protein

smcogs: SMCOG1144: thioesterase superfamily protein

C6354_RS15330: isochorismatase

smcogs: SMCOG1027: isochorismatase

C6354_RS15425: isochorismatase

smcogs: SMCOG1027: isochorismatase

Isomerases: isomerase

C6354_RS15435: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: ligase synthetase

C6354_RS15300: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

C6354_RS15420: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

C6354_RS15430: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000616.4	2.40	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0001185.5	1.60	NRPS	bacillibactin	Bacillus velezensis FZB42
BGC0000309.5	1.07	NRPS	bacillibactin	Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5	1.04	NRPS	paenibactin	Paenibacillus elgii B69
BGC0002075.3	0.87	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0000343.5	0.86	NRPS	enterobactin	Pseudomonas sp. J465
BGC0001132.4	0.77	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.76	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.75	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.75	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000616.4	0.95	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0001185.5	0.93	NRPS	bacillibactin	Bacillus velezensis FZB42
BGC0000309.5	0.81	NRPS	bacillibactin	Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5	0.80	NRPS	paenibactin	Paenibacillus elgii B69
BGC0002075.3	0.74	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0000343.5	0.74	NRPS	enterobactin	Pseudomonas sp. J465
BGC0001132.4	0.71	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001833.4	0.70	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.70	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.70	NRPS	xenematide	Xenorhabdus nematophila AN6/1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor	FPP	C15	acyclic	PP
diterpene precursor	GGPP	C20	acyclic	PP
sesterterpene precursor	GFPP	C25	acyclic	PP
triterpene precursor	HPP	C30	acyclic	PP

Genes with terpene domains:

C6354_RS15300: PT_FPPS_like

Domain 1 (57 - 285): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: unknown

Reactions:: IPP, DMAPP → FPP; IPP, DMAPP → GGPP; IPP, DMAPP → GFPP; IPP, DMAPP → HPP

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 29.38 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.61 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 27.15 out of 29.38

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.87 out of 27.78

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.49 out of 29.38

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.91 out of 29.38

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.52 out of 27.78

Confidence: medium

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.23 out of 21.55

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.11 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.89 out of 27.78

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.73 out of 28.19

Confidence: strong

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.18 out of 28.19

Confidence: medium

Additional weak hits (17):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.88 out of 26.06

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.44 out of 31.73

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.84 out of 29.25

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.61 out of 32.74

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.12 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.52 out of 32.74

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.31 out of 29.38

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.58 out of 26.06

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.44 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.15 out of 26.06

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.10 out of 29.25

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.86 out of 26.06

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.11 out of 33.14

Confidence: weak

OsdR

Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 21.63 out of 30.12

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Terpene

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 51523 - 116845:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 65052 - 116789:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

C6354_RS15420: Gly - Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (456..855): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: FSMTFDISGLELQALVGGETNLYGPTETTIWSAA
Nearest Stachelhaus code(s):: Gly DILQLGLIWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1513..1929): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LSTHFDFSVWEGNQIFGGEVNMYGITETTVHVSY
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

C6354_RS15430: diOH-Bz

Search NORINE for peptide: strict or relaxed

AMP-binding (31..435): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: SISLYPLSSPGGALQVGGAQQVFGMAEGLVNYTR
Nearest Stachelhaus code(s):: diOH-Bz PLPAQGVVNK (100% 8Å match); diOH-Bz or Sal PLPAQGVVNK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
GFPP	Geranylfarnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
HPP	Hexaprenyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1	Ferric Uptake Regulator
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_PVRO01000010.1 - Region 1 - terpene

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Location: 48,427 - 70,310 nt. (total: 21,884 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

C6354_RS16000: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

Hydrolases: hydrolase

C6354_RS15975: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002173.2	0.46	saccharide, terpene	fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol	Aspergillus fumigatus A1163
BGC0001535.3	0.42	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0000313.4	0.36	NRPS	beauvericin	Beauveria bassiana
BGC0002255.3	0.33	PKS	lijiquinone	Ascomycota sp. F53
BGC0000663.5	0.30	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0000686.3	0.30	terpene	helvolic acid	Aspergillus fumigatus Af293
BGC0001575.4	0.29	NRPS	PZN5, PZN6, PZN7, PZN9, PZN10, PZN11	Ruminococcus sp. 5_1_39BFAA
BGC0001338.4	0.28	PKS	citrinin	Monascus ruber
BGC0000154.4	0.28	PKS	stipitatic acid	Talaromyces stipitatus ATCC 10500
BGC0001739.3	0.28	other (other)	phosphonoacetic Acid	Streptomyces sp. NRRL F-525

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002173.2	0.46	saccharide, terpene	fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol	Aspergillus fumigatus A1163
BGC0001535.3	0.42	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0000313.4	0.36	NRPS	beauvericin	Beauveria bassiana
BGC0002255.3	0.33	PKS	lijiquinone	Ascomycota sp. F53
BGC0000663.5	0.30	terpene	hopene	Streptomyces coelicolor A3(2)
BGC0000686.3	0.30	terpene	helvolic acid	Aspergillus fumigatus Af293
BGC0001575.4	0.29	NRPS	PZN5, PZN6, PZN7, PZN9, PZN10, PZN11	Ruminococcus sp. 5_1_39BFAA
BGC0001338.4	0.28	PKS	citrinin	Monascus ruber
BGC0000154.4	0.28	PKS	stipitatic acid	Talaromyces stipitatus ATCC 10500
BGC0001739.3	0.28	other (other)	phosphonoacetic Acid	Streptomyces sp. NRRL F-525

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	hopanoid		C30	hopanoid skeleton	unknown
triterpene	polypodane		C30	polypodane skeleton	unknown

Genes with terpene domains:

C6354_RS15995: T2TS

Domain 1 (5 - 625): Type 2 terpene synthase

Subtype: Squalene substrate

Reactions:: squalene → hopanoid; squalene → polypodane

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.53 out of 26.06

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 26.30 out of 27.78

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.86 out of 27.78

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 28.19

Confidence: medium

Additional weak hits (5):

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.63 out of 25.75

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.14 out of 39.62

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.54 out of 26.06

Confidence: weak

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.10 out of 29.25

Confidence: weak

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.62 out of 21.55

Confidence: weak

Terpene

TFBS Finder

Glossary

No acronyms to display

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_PVRO01000011.1 - Region 1 - NRPS

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Location: 1 - 22,631 nt. (total: 22,631 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: ligase

C6354_RS16145: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

C6354_RS19450: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.71	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001261.3	0.70	NRPS	AM-toxin	Alternaria alternata
BGC0001135.5	0.69	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001166.5	0.68	NRPS	HC-toxin	Alternaria jesenskae
BGC0001132.4	0.68	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000342.4	0.68	NRPS	enniatin	Fusarium equiseti
BGC0001825.4	0.68	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001833.4	0.68	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.67	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.67	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.71	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001261.3	0.70	NRPS	AM-toxin	Alternaria alternata
BGC0001135.5	0.69	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001166.5	0.68	NRPS	HC-toxin	Alternaria jesenskae
BGC0001132.4	0.68	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0000342.4	0.68	NRPS	enniatin	Fusarium equiseti
BGC0001825.4	0.68	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001833.4	0.68	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.67	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.67	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.39 out of 27.78

Confidence: medium

Additional weak hits (7):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.41 out of 29.38

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.81 out of 39.62

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.13 out of 30.25

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.50 out of 29.38

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.37 out of 25.88

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.46 out of 31.73

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.50 out of 26.06

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 22631:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Glu)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

C6354_RS16145: Glu

Search NORINE for peptide: strict or relaxed

AMP-binding (133..538): Glu

nrpys: Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: glu (Glu)

Stachelhaus prediction details:

Stachelhaus sequence:: FGMSFDASIWQWHFFAGGEIHGYGPTEATVDAAF
Nearest Stachelhaus code(s):: Glu DAWHFGGVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ToxT	Regulator of MSHA biosynthesis

NZ_PVRO01000014.1 - Region 1 - NRPS

Download region GenBank file

Download region SVG

Location: 33,215 - 59,442 nt. (total: 26,228 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

C6354_RS17630: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

Transferases: PPTase aminotransferase

C6354_RS17710: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

C6354_RS17715: aminotransferase

smcogs: SMCOG1019: aminotransferase

Hydrolases: esterase

C6354_RS17720: thioesterase

smcogs: SMCOG1004: thioesterase

Ligases: ligase

C6354_RS17725: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

C6354_RS17730: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002075.3	0.75	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001833.4	0.70	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0000426.5	0.69	NRPS	sevadicin	Paenibacillus larvae
BGC0001128.4	0.69	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.68	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001132.4	0.67	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002071.2	0.67	NRPS	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0002286.3	0.67	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001133.4	0.66	NRPS	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0001758.4	0.66	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002075.3	0.75	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0001833.4	0.70	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0000426.5	0.69	NRPS	sevadicin	Paenibacillus larvae
BGC0001128.4	0.69	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.68	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001132.4	0.67	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002071.2	0.67	NRPS	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0002286.3	0.67	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001133.4	0.66	NRPS	taxlllaid A	Xenorhabdus bovienii SS-2004
BGC0001758.4	0.66	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.42 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.88 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.41 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.76 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.50 out of 27.78

Confidence: medium

Additional weak hits (6):

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.88 out of 31.73

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.92 out of 26.06

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.35 out of 30.25

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 21.56 out of 31.73

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.99 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.38 out of 26.06

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 33214 - 59442:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Leu)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

C6354_RS17725: Leu

Search NORINE for peptide: strict or relaxed

AMP-binding (469..867): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: LHVSFDAFTFDAFALFGGEINCYGPTEGTVFATA
Nearest Stachelhaus code(s):: Leu DAFFLGCVFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis

NZ_PVRO01000017.1 - Region 1 - NRPS

Download region GenBank file

Download region SVG

Location: 1 - 22,575 nt. (total: 22,575 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: ligase

C6354_RS18250: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

C6354_RS18255: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

C6354_RS18330: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.68	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000342.4	0.68	NRPS	enniatin	Fusarium equiseti
BGC0001132.4	0.67	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001261.3	0.67	NRPS	AM-toxin	Alternaria alternata
BGC0001135.5	0.67	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001128.4	0.66	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.66	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001758.4	0.65	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0000307.4	0.65	NRPS	AbT1	Aureobasidium pullulans
BGC0001166.5	0.65	NRPS	HC-toxin	Alternaria jesenskae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.68	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000342.4	0.68	NRPS	enniatin	Fusarium equiseti
BGC0001132.4	0.67	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001261.3	0.67	NRPS	AM-toxin	Alternaria alternata
BGC0001135.5	0.67	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001128.4	0.66	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4	0.66	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001758.4	0.65	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0000307.4	0.65	NRPS	AbT1	Aureobasidium pullulans
BGC0001166.5	0.65	NRPS	HC-toxin	Alternaria jesenskae

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.17 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.51 out of 27.78

Confidence: medium

Additional weak hits (4):

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.08 out of 28.14

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.23 out of 33.73

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.29 out of 25.75

Confidence: weak

DasR

Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.85 out of 27.04

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 22575:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-X) + (Pro)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

C6354_RS18250: Pro - Gln

Search NORINE for peptide: strict or relaxed

AMP-binding (469..866): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: LDQAFDVCYQESFFITAGEHNHYGPSETHVVSTY
Nearest Stachelhaus code(s):: Pro DVQFIAHVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1500..1901): Gln

nrpys: Gln

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: glu (Glu)

Stachelhaus prediction details:

Stachelhaus sequence:: FSLTFDASIWEWHFFAGGETNSYGPTEATVEAAY
Nearest Stachelhaus code(s):: Gln DAWHFGSVEK (100% 8Å match); Glu DAWHFGSVEK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

C6354_RS18255: X

AMP-binding (1..211): X

nrpys: Ala, Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: ----FDVTTFEGWLIIGGEWNGYGPTENTTFSTC
Nearest Stachelhaus code(s):: Ala or Val DVFWIGGTFK (85% 8Å match); Val DVFWIGGTFK (82% 8Å match)
Stachelhaus code match:: 100% (strong)

C6354_RS18330: X

AMP-binding (215..385): X

No predictions made

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria

NZ_PVRO01000001.1 - Region 1 - other

Download region GenBank file

Download region SVG

Location: 324,275 - 365,693 nt. (total: 41,419 nt) Show pHMM detection rules used

other: (Neocarzinostat or bcpB or frbD or mitE or prnB or CaiA or bacilysin or orf2_PTase)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

C6354_RS01710: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

C6354_RS01745: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

C6354_RS01765: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: aminotransferase transferase

C6354_RS01660: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

C6354_RS01760: aminotransferase

smcogs: SMCOG1019: aminotransferase

Lyases: dehydratase lyase

C6354_RS01665: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

C6354_RS01670: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

C6354_RS01750: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Translocases: permease

C6354_RS01720: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

C6354_RS01855: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001184.4	0.97	other (other)	bacilysin	Bacillus velezensis FZB42
BGC0000888.5	0.97	other (other)	bacilysin	Bacillus sp. CS93
BGC0000794.5	0.53	saccharide	S-layer glycan	Geobacillus stearothermophilus
BGC0000898.5	0.53	saccharide	desosamine, pikromycin, neomethymycin, narbomycin	Streptomyces venezuelae
BGC0000790.3	0.52	saccharide	O-antigen	Escherichia coli
BGC0000773.3	0.52	saccharide	lipopolysaccharide	Escherichia coli
BGC0000791.3	0.52	saccharide	O-antigen	Cronobacter sakazakii
BGC0001928.2	0.51	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000813.3	0.51	other (other)	K-252a	Nonomuraea longicatena
BGC0000899.4	0.50	saccharide	desosamine	Streptomyces narbonensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001184.4	0.97	other (other)	bacilysin	Bacillus velezensis FZB42
BGC0000888.5	0.97	other (other)	bacilysin	Bacillus sp. CS93
BGC0000794.5	0.53	saccharide	S-layer glycan	Geobacillus stearothermophilus
BGC0000898.5	0.53	saccharide	desosamine, pikromycin, neomethymycin, narbomycin	Streptomyces venezuelae
BGC0000790.3	0.52	saccharide	O-antigen	Escherichia coli
BGC0000773.3	0.52	saccharide	lipopolysaccharide	Escherichia coli
BGC0000791.3	0.52	saccharide	O-antigen	Cronobacter sakazakii
BGC0001928.2	0.51	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000813.3	0.51	other (other)	K-252a	Nonomuraea longicatena
BGC0000899.4	0.50	saccharide	desosamine	Streptomyces narbonensis

Similar known clusters from MIBiG 4.0

Similar subclusters

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.22 out of 18.46

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.26 out of 29.38

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.49 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.85 out of 27.78

Confidence: medium

Additional weak hits (6):

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 21.66 out of 30.97

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 26.15 out of 36.54

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.29 out of 36.54

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.68 out of 33.14

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.37 out of 20.01

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.89 out of 32.93

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1	Ferric Uptake Regulator
RpoN	Regulator of nitrogen assimilation and virulence
ToxT	Regulator of MSHA biosynthesis

NZ_PVRO01000020.1 - Region 1 - NRPS

Download region GenBank file

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Location: 1 - 10,485 nt. (total: 10,485 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: ligase

C6354_RS18520: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.71	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001261.3	0.71	NRPS	AM-toxin	Alternaria alternata
BGC0000396.5	0.70	NRPS	nodularin	Nostoc sp. 73.1
BGC0001833.4	0.70	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001050.5	0.69	NRPS, PKS	thalassospiramide A	Tistrella bauzanensis
BGC0000342.4	0.68	NRPS	enniatin	Fusarium equiseti
BGC0001825.4	0.68	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001135.5	0.68	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002286.3	0.68	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001166.5	0.67	NRPS	HC-toxin	Alternaria jesenskae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.71	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001261.3	0.71	NRPS	AM-toxin	Alternaria alternata
BGC0000396.5	0.70	NRPS	nodularin	Nostoc sp. 73.1
BGC0001833.4	0.70	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001050.5	0.69	NRPS, PKS	thalassospiramide A	Tistrella bauzanensis
BGC0000342.4	0.68	NRPS	enniatin	Fusarium equiseti
BGC0001825.4	0.68	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001135.5	0.68	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0002286.3	0.68	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001166.5	0.67	NRPS	HC-toxin	Alternaria jesenskae

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 10485:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Val - Asp)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

C6354_RS19480: Val - Asp

Search NORINE for peptide: strict or relaxed

AMP-binding (470..864): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: LHSGFDAGTFEGWLIIGGDWNGYGPTENTTFSTS
Nearest Stachelhaus code(s):: Val DAFWIGGTFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1502..1904): Asp

nrpys: Asp

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asp (Asp)

Stachelhaus prediction details:

Stachelhaus sequence:: YWFSFDLGYTAPKLVLGGEINHYGPTETTIGAIA
Nearest Stachelhaus code(s):: Asp DLTKVGHIGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

NZ_PVRO01000002.1 - Region 1 - transAT-PKS

Download region GenBank file

Download region SVG

Location: 90,832 - 179,062 nt. (total: 88,231 nt) Show pHMM detection rules used

transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

C6354_RS04965: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

C6354_RS04995: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

C6354_RS05005: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

C6354_RS05010: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

C6354_RS05020: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acylase kinase

C6354_RS05025: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

C6354_RS05135: PfkB domain protein

smcogs: SMCOG1276: PfkB domain protein

Hydrolases: deacetylase deformylase hydrolase phosphatase

C6354_RS04920: inositol monophosphatase

smcogs: SMCOG1207: inositol monophosphatase

C6354_RS04955: polysaccharide deacetylase

smcogs: SMCOG1235: polysaccharide deacetylase

C6354_RS04985: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

C6354_RS04990: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

C6354_RS05045: peptide deformylase

smcogs: SMCOG1275: peptide deformylase

C6354_RS05050: hydrolase

smcogs: SMCOG1179: hydrolase

Ligases: synthase

C6354_RS04975: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

C6354_RS05015: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000181.5	0.89	PKS	macrolactin H	Bacillus velezensis FZB42
BGC0001383.3	0.89	PKS	macrolactin H, macrolactin B, macrolactin 1c, macrolactin E	Jeotgalibacillus marinus
BGC0001534.3	0.70	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001276.3	0.64	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.64	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001275.3	0.64	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0001160.5	0.63	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.63	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001284.4	0.63	PKS	alternariol	Parastagonospora nodorum SN15

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000181.5	0.89	PKS	macrolactin H	Bacillus velezensis FZB42
BGC0001383.3	0.89	PKS	macrolactin H, macrolactin B, macrolactin 1c, macrolactin E	Jeotgalibacillus marinus
BGC0001534.3	0.70	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001276.3	0.64	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.64	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001275.3	0.64	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0001160.5	0.63	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.63	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001284.4	0.63	PKS	alternariol	Parastagonospora nodorum SN15

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.63 out of 27.78

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.94 out of 21.55

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.16 out of 26.06

Confidence: medium

Additional weak hits (6):

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.35 out of 26.33

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.27 out of 30.22

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.56 out of 29.38

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.30 out of 26.06

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.99 out of 33.14

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.94 out of 29.65

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 90831 - 179062:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (ohmal - ccmal - ccmal) + (ccmal) + (ccmal - mal) + (ccmal - mal) + (ohmal) + (ohmal - mal)
Non-colinear ordering:: C6354_RS05020 + C6354_RS05015 + C6354_RS05010 + C6354_RS05005 + C6354_RS05000 + C6354_RS04995 + C6354_RS04990

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

C6354_RS05025: mal

PKS_AT (4..282): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 92.6
inactive: 32.0
Methoxymalonyl-CoA: 28.0
Methylmalonyl-CoA: 20.8
Propionyl-CoA: 17.4
fatty_acid: 13.9
trans-1,2-CPDA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis

NZ_PVRO01000002.1 - Region 2 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 330,632 - 359,521 nt. (total: 28,890 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

C6354_RS06015: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

C6354_RS06025: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000554.4	0.56	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000516.4	0.53	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000626.3	0.52	ribosomal	thuricin	Bacillus thuringiensis
BGC0000528.5	0.51	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001555.4	0.51	ribosomal	colicin V	Escherichia coli chi7122
BGC0001210.5	0.51	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000590.5	0.50	ribosomal	microcin N	Escherichia coli
BGC0001311.5	0.50	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0000539.5	0.50	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0000527.5	0.49	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000554.4	0.56	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000516.4	0.53	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000626.3	0.52	ribosomal	thuricin	Bacillus thuringiensis
BGC0000528.5	0.51	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001555.4	0.51	ribosomal	colicin V	Escherichia coli chi7122
BGC0001210.5	0.51	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000590.5	0.50	ribosomal	microcin N	Escherichia coli
BGC0001311.5	0.50	ribosomal	flavecins	Ruminococcus flavefaciens FD-1
BGC0000539.5	0.50	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0000527.5	0.49	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for C6354_RS06015

C6354_RS18850

Leader:

MCKLCGPKKVIVTETGFGA

Core:

VFHPCPNCKTGTDLTPVIKRLERMVQDAKARLDARV

Core with dehydrations:

VFHPCysPNCysKDhbGDhbDLDhbPVIKRLERMVQDAKARLDARV

antiSMASH-DB 4.0 matches for C6354_RS18850

100.0%

NC_023073.1and 25 others:

NZ_CP010556.1 Lanthipeptides: SB45_RS19805_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19795_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20400_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22075_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS21000_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21480_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19740_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19585_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20470_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21110_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20035_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16480_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06705_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18975_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06485_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16830_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06200_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12895_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06150_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06335_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11720_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS03045_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19745_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19365_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18850_lanthipeptide

Lanthipeptides: U722_RS20005_lanthipeptide

1

VFHPCPNCKTGTDLTPVIKRLERMVQDAKARLDARV

36

VFHPCPNCKTGTDLTPVIKRLERMVQDAKARLDARV

1

VFHPCPNCKTGTDLTPVIKRLERMVQDAKARLDARV

36

97.2%

NZ_CP025341.1:

Lanthipeptides: CXR48_RS19565_lanthipeptide

1

VFHPCPNCKTGTDLTPVIKRLERMVQDAKARLDARV

36

VFHPCPNCKTGTDLTPVIKRLERMVQDAKARLD RV

1

VFHPCPNCKTGTDLTPVIKRLERMVQDAKARLDLRV

36

89.7%

NZ_CP023075.1and 8 others:

NZ_CP035393.1 Lanthipeptides: ES966_RS21105_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20970_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19665_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17705_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03370_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01895_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00520_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122700_lanthipeptide

Lanthipeptides: CK238_RS20695_lanthipeptide

1

VFHPCPNCKTGTDLTPVIKRLERMVQDAKARLDARV

36

VFHPCPNCKTGTDLTPVIKRLERMVQDAK RLDARV

1

VFHPCPNCKTGTDLTPVIKRLERMVQDAKVRLDARV

36

with 2 more sequence matches

22.2%

NC_015600.1and 17 others:

NZ_AP020310.1 Lanthipeptides: SAGCMC97051_RS07300_lanthipeptideNZ_ATVP01000001.1 Lanthipeptides: G574_RS11150_lanthipeptideNZ_BCFB01000042.1 Lanthipeptides: GOZ36_RS07980_lanthipeptideNZ_CP024974.1 Lanthipeptides: CVO91_RS06555_lanthipeptideNZ_CP068708.1 Lanthipeptides: JM964_RS04040_lanthipeptideNZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptideNZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptideNZ_FIKS01000005.1 Lanthipeptides: A0525_RS10015_lanthipeptideNZ_GL636070.1 Lanthipeptides: HMPREF9171_RS106200_lanthipeptideNZ_JADPLU010000018.1 Lanthipeptides: I4V82_RS09545_lanthipeptideNZ_JAIMDQ010000006.1 Lanthipeptides: K6V44_RS04045_lanthipeptideNZ_JAKVIE010000017.1 Lanthipeptides: MK857_RS08340_lanthipeptideNZ_JAMDIB010000004.1 Lanthipeptides: M5P35_RS04030_lanthipeptideNZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptideNZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptideNZ_LR594050.1 Lanthipeptides: FGL20_RS03485_lanthipeptideNZ_SSXN01000004.1 Lanthipeptides: FAJ36_RS04715_lanthipeptide

Lanthipeptides: SGPB_RS10680_lanthipeptide

6

PNCKTGTDLTPVIK

19

P CKTG +T IK

9

PGCKTGILMTCAIK

22

22.2%

NZ_CP059471.1and 3 others:

NZ_FNZW01000001.1 Lanthipeptides: BMZ61_RS02110_lanthipeptideNZ_FOYC01000001.1 Lanthipeptides: BMZ88_RS03370_lanthipeptideNZ_KE384124.1 Lanthipeptides: G597_RS0106700_lanthipeptide

Lanthipeptides: H1R75_RS06635_lanthipeptide

6

PNCKTGTDLTPVIK

19

P CKTG +T IK

9

PGCKTGALMTCPIK

22

MIBiG 4.0 matches for C6354_RS18850

13.9%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

6

PNCKTG

11

P CKTG

9

PGCKTG

14

C6354_RS18855

Leader:

MKKDFQALTPMTEEELKNLAGG

Core:

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

Core with dehydrations:

DhaDADhbPMDhbVDhbPDhbDhbIDhbIPIDhaLAGCysPDhbDhbKCysADhaIVDhaPCysND

antiSMASH-DB 4.0 matches for C6354_RS18855

100.0%

NC_023073.1and 71 others:

NC_023073.1 Lanthipeptides: U722_RS19995_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide

Lanthipeptides: U722_RS19995_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

97.2%

NC_023073.1and 71 others:

NC_023073.1 Lanthipeptides: U722_RS19990_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide

Lanthipeptides: U722_RS19990_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

S+ATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

94.4%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10245_lanthipeptide

Lanthipeptides: J7E20_RS10245_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SDA PMT+TPTTITIPISLAGCPTTKCASIVSPCND

1

SDAAPMTITPTTITIPISLAGCPTTKCASIVSPCND

36

with 60 more sequence matches

Only the first 10 are displayed here.

66.7%

NZ_JAMDLZ010000027.1:

Lanthipeptides: M5W82_RS15520_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP T+TIPISLAGCPTTKCASIVSPC

8

TPLTVTIPISLAGCPTTKCASIVSPCKG

35

63.9%

NZ_WIXN01000006.1and 1 other:

NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide

Lanthipeptides: GHD25_RS06900_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPC

34

DATP T PTTI IP+SLA CPTT C S SPC

1

EDATPDT-HPTTI-IPVSLAVCPTTTCRSFSSPC

32

63.2%

NZ_AUCI01000015.1and 1 other:

NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide

Lanthipeptides: G475_RS0114655_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SD P + TT+TIPIS GCPTTKCAS+V PCND

3

SDQQPASHPTTTVTIPISAWGCPTTKCASVVEPCND

38

63.2%

NZ_FOXD01000022.1and 1 other:

NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide

Lanthipeptides: BM124_RS15255_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SD P + TT+TIPIS GCPTTKCAS+V PCND

3

SDQQPASHPTTTVTIPISAWGCPTTKCASVVKPCND

38

61.1%

NZ_CP063142.1and 5 others:

NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide

Lanthipeptides: HPB58_RS21455_lanthipeptide

12

TITIPISLAGCPTTKCASIVSPCND

36

T+TIPISLA CPTT+CASIVSPCND

8

TVTIPISLAACPTTQCASIVSPCND

32

61.1%

NZ_LT745762.1and 1 other:

NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide

Lanthipeptides: B2C77_RS21505_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP TI IP+SLA CPTTKCAS+V PCND

7

TPATI-IPVSLAICPTTKCASVVKPCND

33

58.3%

NZ_BOSN01000007.1and 3 others:

NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide

Lanthipeptides: KJS43_RS18000_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP TI IP+SLA CPTTKCAS+V PCN

7

TPATI-IPVSLAICPTTKCASVVKPCNG

33

58.3%

NZ_BQME02000001.1and 3 others:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide

Lanthipeptides: MFF31_RS04090_lanthipeptide

12

TITIPISLAGCPTTKCASIVSPCN

35

TI IPISLA CPTT+CASIVSPCN

6

TIIIPISLAACPTTRCASIVSPCN

29

55.6%

NZ_BQME02000001.1and 1 other:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04085_lanthipeptide

Lanthipeptides: MFF31_RS04085_lanthipeptide

12

TITIPISLAGCPTTKCASIVSPCN

35

TI IPISLA CPTT+CASIVS CN

6

TIIIPISLAACPTTRCASIVSSCN

29

55.6%

NZ_KQ040792.1and 1 other:

NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide

Lanthipeptides: WH45_RS23705_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP TI IP+SLA CPTT+CASIV CN

8

TPATI-IPVSLAICPTTRCASIVESCNG

34

MIBiG 4.0 matches for C6354_RS18855

24.3%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

13

ITIPISLAGCPTTKCAS

29

+ + +S A CPTTKC S

19

VAVGVSAAFCPTTKCTS

35

19.4%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

22

CPTTKCAS

29

CPTTKC S

17

CPTTKCTS

24

C6354_RS18860

Leader:

MKKEFLALELMTEEELKELAGG

Core:

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

Core with dehydrations:

DhaEADhbPMDhbVDhbPDhbDhbIDhbIPIDhaLAGCysPDhbDhbKCysADhaIVDhaPCysND

antiSMASH-DB 4.0 matches for C6354_RS18860

100.0%

NC_023073.1and 71 others:

NC_023073.1 Lanthipeptides: U722_RS19990_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide

Lanthipeptides: U722_RS19990_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

97.2%

NC_023073.1and 71 others:

NC_023073.1 Lanthipeptides: U722_RS19995_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide

Lanthipeptides: U722_RS19995_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

S+ATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

97.2%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10240_lanthipeptide

Lanthipeptides: J7E20_RS10240_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SEATPMT+TPTTITIPISLAGCPTTKCASIVSPCND

1

SEATPMTITPTTITIPISLAGCPTTKCASIVSPCND

36

with 60 more sequence matches

Only the first 10 are displayed here.

91.7%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10245_lanthipeptide

Lanthipeptides: J7E20_RS10245_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

S+A PMT+TPTTITIPISLAGCPTTKCASIVSPCND

1

SDAAPMTITPTTITIPISLAGCPTTKCASIVSPCND

36

66.7%

NZ_JAMDLZ010000027.1:

Lanthipeptides: M5W82_RS15520_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP T+TIPISLAGCPTTKCASIVSPC

8

TPLTVTIPISLAGCPTTKCASIVSPCKG

35

63.9%

NZ_KQ040792.1and 1 other:

NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide

Lanthipeptides: WH45_RS23705_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCN

35

+E+TP TP TI IP+SLA CPTT+CASIV CN

1

AESTP-NGTPATI-IPVSLAICPTTRCASIVESCN

33

61.1%

NZ_CP063142.1and 5 others:

NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide

Lanthipeptides: HPB58_RS21455_lanthipeptide

12

TITIPISLAGCPTTKCASIVSPCND

36

T+TIPISLA CPTT+CASIVSPCND

8

TVTIPISLAACPTTQCASIVSPCND

32

61.1%

NZ_LT745762.1and 1 other:

NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide

Lanthipeptides: B2C77_RS21505_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP TI IP+SLA CPTTKCAS+V PCND

7

TPATI-IPVSLAICPTTKCASVVKPCND

33

61.1%

NZ_WIXN01000006.1and 1 other:

NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide

Lanthipeptides: GHD25_RS06900_lanthipeptide

2

EATPMTVTPTTITIPISLAGCPTTKCASIVSPC

34

+ATP T PTTI IP+SLA CPTT C S SPC

2

DATPDT-HPTTI-IPVSLAVCPTTTCRSFSSPC

32

60.5%

NZ_AUCI01000015.1and 1 other:

NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide

Lanthipeptides: G475_RS0114655_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

S+ P + TT+TIPIS GCPTTKCAS+V PCND

3

SDQQPASHPTTTVTIPISAWGCPTTKCASVVEPCND

38

60.5%

NZ_FOXD01000022.1and 1 other:

NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide

Lanthipeptides: BM124_RS15255_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

S+ P + TT+TIPIS GCPTTKCAS+V PCND

3

SDQQPASHPTTTVTIPISAWGCPTTKCASVVKPCND

38

58.3%

NZ_BOSN01000007.1and 3 others:

NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide

Lanthipeptides: KJS43_RS18000_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP TI IP+SLA CPTTKCAS+V PCN

7

TPATI-IPVSLAICPTTKCASVVKPCNG

33

58.3%

NZ_BQME02000001.1and 3 others:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide

Lanthipeptides: MFF31_RS04090_lanthipeptide

12

TITIPISLAGCPTTKCASIVSPCN

35

TI IPISLA CPTT+CASIVSPCN

6

TIIIPISLAACPTTRCASIVSPCN

29

MIBiG 4.0 matches for C6354_RS18860

24.3%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

13

ITIPISLAGCPTTKCAS

29

+ + +S A CPTTKC S

19

VAVGVSAAFCPTTKCTS

35

19.4%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

22

CPTTKCAS

29

CPTTKC S

17

CPTTKCTS

24

C6354_RS06030

Leader:

MNEKMYRFAGDLREELEEISLS

Core:

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

Core with dehydrations:

EFDhaGGGGAEQRGIDhaQGNDGKLCysDhbLDhbWECysGLCysPDhbHDhbCysWCys

antiSMASH-DB 4.0 matches for C6354_RS06030

100.0%

NC_023073.1and 65 others:

NC_023073.1 Lanthipeptides: U722_RS06170_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptide

Lanthipeptides: U722_RS06170_lanthipeptide

1

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

1

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

97.4%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10220_lanthipeptide

Lanthipeptides: J7E20_RS10220_lanthipeptide

1

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTC+C

1

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCFC

38

86.8%

NZ_CP016371.1and 7 others:

NZ_CP016371.1 Lanthipeptides: A5891_RS06120_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptide

Lanthipeptides: A5891_RS06120_lanthipeptide

6

GGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

GGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

1

GGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

33

with 92 more sequence matches

Only the first 10 are displayed here.

71.1%

NZ_BQME02000001.1and 1 other:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04105_lanthipeptide

Lanthipeptides: MFF31_RS04105_lanthipeptide

8

AEQRGISQGNDGKLCTLTWECGLCPTHTC-WC

38

AEQRGISQGNDGK CTLTWEC +CPT TC WC

1

AEQRGISQGNDGKYCTLTWECSVCPTLTCFWC

32

68.4%

NZ_CP063142.1and 10 others:

NZ_CP063142.1 Lanthipeptides: HPB58_RS21475_lanthipeptideNZ_FOXX01000007.1 Lanthipeptides: BM012_RS26100_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptideNZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptideNZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptideNZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptideNZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptide

Lanthipeptides: HPB58_RS21475_lanthipeptide

8

AEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AEQRGISQGNDG CT+TWEC +CPTHTCWC

1

AEQRGISQGNDGHQCTITWECSICPTHTCWC

31

68.4%

NZ_FOXD01000022.1and 1 other:

NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15270_lanthipeptide

Lanthipeptides: BM124_RS15270_lanthipeptide

8

AEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AE RGISQGNDG CT+TWECG+CPTHTCWC

3

AEPRGISQGNDGDYCTITWECGMCPTHTCWC

33

68.4%

NZ_KQ040792.1and 1 other:

NZ_KQ040792.1 Lanthipeptides: WH45_RS23330_lanthipeptide

Lanthipeptides: WH45_RS23330_lanthipeptide

8

AEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AE +G+SQGNDGK+CTLTWECGLCPTHTC+C

1

AEVQGLSQGNDGKVCTLTWECGLCPTHTCFC

31

65.8%

NZ_BOSN01000007.1and 3 others:

NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18005_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptide

Lanthipeptides: KJS43_RS18005_lanthipeptide

7

GAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AE GISQGNDGK CT+TWEC +CPTHTCWC

1

AAEPMGISQGNDGKYCTITWECSICPTHTCWC

32

65.8%

NZ_LT745762.1and 1 other:

NZ_LT745762.1 Lanthipeptides: B2C77_RS00795_lanthipeptide

Lanthipeptides: B2C77_RS00795_lanthipeptide

7

GAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AE GISQGNDGK CT+TWEC +CPTHTCWC

1

AAEPMGISQGNDGKWCTVTWECSICPTHTCWC

32

63.2%

NZ_AUCI01000015.1and 1 other:

NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114640_lanthipeptide

Lanthipeptides: G475_RS0114640_lanthipeptide

6

GGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

E RG+SQGNDG CT+TWECG+CPTHTCWC

1

ADVETRGLSQGNDGDYCTITWECGMCPTHTCWC

33

63.2%

NZ_CP101913.1and 1 other:

NZ_CP101913.1 Lanthipeptides: NP440_RS09135_lanthipeptide

Lanthipeptides: NP440_RS09135_lanthipeptide

7

GAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AE GIS+ NDGK CTLTWEC +CPTHTCWC

1

AAEPMGISEDNDGKYCTLTWECSICPTHTCWC

32

63.2%

NZ_KV917378.1and 1 other:

NZ_KV917378.1 Lanthipeptides: BK581_RS07320_lanthipeptide

Lanthipeptides: BK581_RS07320_lanthipeptide

8

AEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

A+ +GISQGNDGK CT+TWEC +CPTHTCWC

1

ADVQGISQGNDGKYCTITWECSICPTHTCWC

31

55.3%

NZ_CP040417.1and 7 others:

NZ_CP040417.1 Lanthipeptides: FE328_RS09040_lanthipeptideNZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptideNZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptideNZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptideNZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide

Lanthipeptides: FE328_RS09040_lanthipeptide

5

GGGAEQRGISQGNDGKLCTLTWECGLCPTHTCW

37

G G R +S+GN GK+CTLTWECG+CP+HTC+

1

GVGKWIRKLSKGNTGKVCTLTWECGICPSHTCF

33

MIBiG 4.0 matches for C6354_RS06030

23.7%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

16

GNDGKLCTLTWEC

28

GN G CTLT EC

11

GNKGAYCTLTVEC

23

23.7%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

16

GNDGKLCTLTWEC

28

GN+G CTLT EC

13

GNNGGWCTLTKEC

25

15.8%

BGC0000580.3 (EGD17355.1):

Lasso peptide: xanthomonin II or xanthomonin I

6

GGAEQRGISQ

15

GG GISQ

10

GGITTLGISQ

19

with 1 more sequence matches

12.8%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

22

CTLTWEC

28

CTL+ EC

28

CTLSKEC

34

allorf_330876_330977

Leader:

MSYVCHLEVNRRSQKAARLEAA

Core:

FYYRQSCRRWR

Core with dehydrations:

FYYRQDhaCysRRWR

antiSMASH-DB 4.0 matches for allorf_330876_330977

100.0%

NC_023073.1and 25 others:

NZ_CP010556.1 Lanthipeptides: allorf_1184096_1184197_lanthipeptideNZ_CP016371.1 Lanthipeptides: allorf_1217185_1217286_lanthipeptideNZ_CP016395.1 Lanthipeptides: allorf_1280116_1280217_lanthipeptideNZ_CP018295.1 Lanthipeptides: allorf_1237649_1237750_lanthipeptideNZ_CP023133.1 Lanthipeptides: allorf_0814210_0814311_lanthipeptideNZ_CP025341.1 Lanthipeptides: allorf_1220484_1220585_lanthipeptideNZ_CP027429.1 Lanthipeptides: allorf_2632526_2632603_lanthipeptideNZ_CP028440.1 Lanthipeptides: allorf_1156108_1156209_lanthipeptideNZ_CP031694.1 Lanthipeptides: allorf_3744466_3744567_lanthipeptideNZ_CP033967.1 Lanthipeptides: allorf_3531374_3531475_lanthipeptideNZ_CP044133.1 Lanthipeptides: allorf_1298847_1298948_lanthipeptideNZ_CP059405.1 Lanthipeptides: allorf_3182941_3183042_lanthipeptideNZ_CP059495.1 Lanthipeptides: allorf_1285088_1285189_lanthipeptideNZ_CP064091.1 Lanthipeptides: allorf_3842801_3842902_lanthipeptideNZ_CP065790.1 Lanthipeptides: allorf_1242067_1242168_lanthipeptideNZ_CP072310.1 Lanthipeptides: allorf_3353378_3353479_lanthipeptideNZ_CP074685.1 Lanthipeptides: allorf_1233992_1234093_lanthipeptideNZ_CP075054.1 Lanthipeptides: allorf_2689692_2689793_lanthipeptideNZ_CP088300.1 Lanthipeptides: allorf_1187843_1187944_lanthipeptideNZ_CP090905.1 Lanthipeptides: allorf_1214408_1214509_lanthipeptideNZ_CP094618.1 Lanthipeptides: allorf_1148352_1148453_lanthipeptideNZ_CP119675.1 Lanthipeptides: allorf_2196063_2196164_lanthipeptideNZ_KN050798.1 Lanthipeptides: allorf_0358200_0358301_lanthipeptideNZ_LN999829.1 Lanthipeptides: allorf_1199095_1199196_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: allorf_330876_330977_lanthipeptide

Lanthipeptides: allorf_1251961_1252062_lanthipeptide

1

FYYRQSCRRWR

11

FYYRQSCRRWR

1

FYYRQSCRRWR

11

5.9%

NZ_FMXV01000022.1:

Lanthipeptides: allorf_002190_002423_lanthipeptide

3

YRQSCRRWR

11

+ ++C RWR

57

WERACSRWR

65

allorf_335356_335517

Leader:

MNRGARFYIHWSYAAQEVLGG

Core:

QHGENSVMMQKPFLRFKMMTFCRLRFKPAENR

Core with dehydrations:

QHGENDhaVMMQKPFLRFKMMDhbFCysRLRFKPAENR

antiSMASH-DB 4.0 matches for allorf_335356_335517

100.0%

NZ_CP017775.1and 9 others:

NZ_CP023075.1 Lanthipeptides: allorf_1289301_1289462_lanthipeptideNZ_CP035393.1 Lanthipeptides: allorf_1371482_1371643_lanthipeptideNZ_CP044444.1 Lanthipeptides: allorf_2629421_2629582_lanthipeptideNZ_CP059405.1 Lanthipeptides: allorf_3178400_3178561_lanthipeptideNZ_CP083716.1 Lanthipeptides: allorf_113041_113202_lanthipeptideNZ_CP092110.1 Lanthipeptides: allorf_0702092_0702253_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS03015_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122870_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: allorf_335356_335517_lanthipeptide

Lanthipeptides: allorf_1372345_1372506_lanthipeptide

1

QHGENSVMMQKPFLRFKMMTFCRLRFKPAENR

32

QHGENSVMMQKPFLRFKMMTFCRLRFKPAENR

1

QHGENSVMMQKPFLRFKMMTFCRLRFKPAENR

32

40.6%

NC_023073.1and 9 others:

NZ_CP016395.1 Lanthipeptides: BBJ33_RS20395_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21475_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19560_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19590_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20475_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06455_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06170_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06305_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19360_lanthipeptide

Lanthipeptides: U722_RS20000_lanthipeptide

1

QHGENSVMMQKPFLR

15

QHG+ SVMMQKPFLR

1

QHGDYSVMMQKPFLR

15

21.9%

NZ_JXCA02000027.1:

Lanthipeptides: allorf_403131_403280_lanthipeptide

10

QKPFLRFKMMTFC

22

Q PFLR + FC

12

QPPFLREGLCKFC

24

with 1 more sequence matches

15.2%

NZ_KB235948.1:

Lanthipeptides: OSC10802_RS0121020_lanthipeptide

15

RFKMMTFCRLRFKPAENR

32

RF C+ F PA+ R

11

RFMKAMLCKDSFSPADRR

28

allorf_337625_337702

Leader:

MRIHSIFIRMQGLYA

Core:

QVICPTNATY

Core with dehydrations:

QVICysPDhbNADhbY

antiSMASH-DB 4.0 matches for allorf_337625_337702

100.0%

NZ_CP016371.1and 22 others:

NZ_CP017775.1 Lanthipeptides: allorf_1370160_1370237_lanthipeptideNZ_CP018295.1 Lanthipeptides: allorf_1230930_1231007_lanthipeptideNZ_CP023075.1 Lanthipeptides: allorf_1287116_1287193_lanthipeptideNZ_CP027429.1 Lanthipeptides: allorf_2639262_2639339_lanthipeptideNZ_CP027429.1 Lanthipeptides: allorf_2639262_2639339_lanthipeptideNZ_CP033967.1 Lanthipeptides: allorf_3538116_3538193_lanthipeptideNZ_CP033967.1 Lanthipeptides: allorf_3538116_3538193_lanthipeptideNZ_CP044133.1 Lanthipeptides: allorf_1292127_1292204_lanthipeptideNZ_CP044444.1 Lanthipeptides: allorf_2627237_2627314_lanthipeptideNZ_CP048002.1 Lanthipeptides: allorf_3123788_3123865_lanthipeptideNZ_CP059405.1 Lanthipeptides: allorf_3176215_3176292_lanthipeptideNZ_CP059495.1 Lanthipeptides: allorf_1278377_1278454_lanthipeptideNZ_CP064091.1 Lanthipeptides: allorf_3836090_3836167_lanthipeptideNZ_CP083716.1 Lanthipeptides: allorf_110856_110933_lanthipeptideNZ_CP092110.1 Lanthipeptides: allorf_0704361_0704438_lanthipeptideNZ_CP092110.1 Lanthipeptides: allorf_0704361_0704438_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: allorf_101096_101173_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: allorf_101096_101173_lanthipeptideNZ_KB206086.1 Lanthipeptides: allorf_0474373_0474450_lanthipeptideNZ_KN050798.1 Lanthipeptides: allorf_0351480_0351557_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: allorf_337625_337702_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: allorf_337625_337702_lanthipeptide

Lanthipeptides: allorf_1210473_1210550_lanthipeptide

1

QVICPTNATY

10

QVICPTNATY

1

QVICPTNATY

10

allorf_344018_344200

Leader:

MKGGEIWNMKKNFSALYETSEQELKELVGG

Core:

QNSVSITTYPITNHICPTITVGCACPQRQV

Core with dehydrations:

QNDhaVDhaIDhbDhbYPIDhbNHICysPDhbIDhbVGCysACysPQRQV

antiSMASH-DB 4.0 matches for allorf_344018_344200

100.0%

NZ_CP016371.1and 25 others:

NZ_CP017775.1 Lanthipeptides: allorf_1362373_1362555_lanthipeptideNZ_CP018295.1 Lanthipeptides: allorf_1224462_1224620_lanthipeptideNZ_CP023075.1 Lanthipeptides: allorf_1280618_1280800_lanthipeptideNZ_CP027429.1 Lanthipeptides: allorf_2645650_2645832_lanthipeptideNZ_CP027429.1 Lanthipeptides: allorf_2645650_2645832_lanthipeptideNZ_CP033967.1 Lanthipeptides: allorf_3544503_3544661_lanthipeptideNZ_CP033967.1 Lanthipeptides: allorf_3544503_3544661_lanthipeptideNZ_CP035393.1 Lanthipeptides: allorf_1361512_1361694_lanthipeptideNZ_CP044133.1 Lanthipeptides: allorf_1285659_1285817_lanthipeptideNZ_CP044444.1 Lanthipeptides: allorf_2620740_2620922_lanthipeptideNZ_CP048002.1 Lanthipeptides: allorf_3117293_3117475_lanthipeptideNZ_CP059405.1 Lanthipeptides: allorf_3169717_3169899_lanthipeptideNZ_CP059495.1 Lanthipeptides: allorf_1271882_1272064_lanthipeptideNZ_CP064091.1 Lanthipeptides: allorf_3829595_3829777_lanthipeptideNZ_CP083716.1 Lanthipeptides: allorf_104358_104540_lanthipeptideNZ_CP092110.1 Lanthipeptides: allorf_0710754_0710936_lanthipeptideNZ_CP092110.1 Lanthipeptides: allorf_0710754_0710936_lanthipeptideNZ_CP116013.1 Lanthipeptides: allorf_0410910_0411092_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: allorf_107486_107668_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: allorf_107486_107668_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: allorf_050414_050596_lanthipeptideNZ_KB206086.1 Lanthipeptides: allorf_0467875_0468057_lanthipeptideNZ_KN050798.1 Lanthipeptides: allorf_0345012_0345170_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: allorf_344018_344200_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: allorf_344018_344200_lanthipeptide

Lanthipeptides: allorf_1203980_1204162_lanthipeptide

1

QNSVSITTYPITNHICPTITVGCACPQRQV

30

QNSVSITTYPITNHICPTITVGCACPQRQV

1

QNSVSITTYPITNHICPTITVGCACPQRQV

30

93.3%

NC_023073.1and 18 others:

NZ_CP010556.1 Lanthipeptides: allorf_1170865_1171047_lanthipeptideNZ_CP016395.1 Lanthipeptides: allorf_1266893_1267075_lanthipeptideNZ_CP023133.1 Lanthipeptides: allorf_0800979_0801161_lanthipeptideNZ_CP025341.1 Lanthipeptides: allorf_1207246_1207428_lanthipeptideNZ_CP028440.1 Lanthipeptides: allorf_1169247_1169429_lanthipeptideNZ_CP028440.1 Lanthipeptides: allorf_1169247_1169429_lanthipeptideNZ_CP031694.1 Lanthipeptides: allorf_3757607_3757789_lanthipeptideNZ_CP031694.1 Lanthipeptides: allorf_3757607_3757789_lanthipeptideNZ_CP065790.1 Lanthipeptides: allorf_1228836_1229018_lanthipeptideNZ_CP072310.1 Lanthipeptides: allorf_3340146_3340328_lanthipeptideNZ_CP074685.1 Lanthipeptides: allorf_1220760_1220942_lanthipeptideNZ_CP075054.1 Lanthipeptides: allorf_2702843_2703025_lanthipeptideNZ_CP075054.1 Lanthipeptides: allorf_2702843_2703025_lanthipeptideNZ_CP088300.1 Lanthipeptides: allorf_1174611_1174793_lanthipeptideNZ_CP090905.1 Lanthipeptides: allorf_1201177_1201359_lanthipeptideNZ_CP094618.1 Lanthipeptides: allorf_1135121_1135303_lanthipeptideNZ_CP119675.1 Lanthipeptides: allorf_2182837_2183019_lanthipeptideNZ_LN999829.1 Lanthipeptides: allorf_1186077_1186259_lanthipeptide

Lanthipeptides: allorf_1238739_1238921_lanthipeptide

1

QNSVSITTYPITNHICPTITVGCACPQRQV

30

QNSVSITT PITNH+CPTITVGCACPQRQV

1

QNSVSITTIPITNHVCPTITVGCACPQRQV

30

66.7%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10235_lanthipeptide

Lanthipeptides: J7E20_RS10235_lanthipeptide

1

QNSVSITTYPITNHICPTITVGCACPQRQV

30

QN +SITT P T H+C T+TVGCACPQ+Q+

1

QNLISITTIPFT-HLCATVTVGCACPQKQI

29

with 3 more sequence matches

23.5%

NZ_CP048048.1and 2 others:

NZ_CP048050.1 Lanthipeptides: GW570_RS15170_lanthipeptideNZ_CP088267.1 Lanthipeptides: LRE50_RS16510_lanthipeptide

Lanthipeptides: GW571_RS15175_lanthipeptide

8

TYPITNHICPTITVGCACPQRQ

29

T+ +T +C TI AC Q

8

TFKLTVKVCRTIITTTACGSTQ

29

20.0%

NZ_JANIOB010000033.1:

Lanthipeptides: NQ113_RS28010_lanthipeptide

11

ITNHICPTI

19

TN +CPTI

15

FTNRLCPTI

23

15.8%

NZ_KB907258.1:

Lanthipeptides: G358_RS0114910_lanthipeptide

2

NSVSITTYPITNHICPTIT

20

NS+ I+ Y + CP++

6

NSIRISIYKCLSLFCPSVA

24

MIBiG 4.0 matches for allorf_344018_344200

13.3%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

18

TITVGC

23

T+TV C

18

TLTVEC

23

Lanthipeptide(s) for C6354_RS06025

C6354_RS18855

Leader:

MKKDFQALTPMTEEELKNLAGG

Core:

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

Core with dehydrations:

DhaDADhbPMDhbVDhbPDhbDhbIDhbIPIDhaLAGCysPDhbDhbKCysADhaIVDhaPCysND

antiSMASH-DB 4.0 matches for C6354_RS18855

100.0%

NC_023073.1and 71 others:

NC_023073.1 Lanthipeptides: U722_RS19995_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide

Lanthipeptides: U722_RS19995_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

97.2%

NC_023073.1and 71 others:

NC_023073.1 Lanthipeptides: U722_RS19990_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide

Lanthipeptides: U722_RS19990_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

S+ATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

94.4%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10245_lanthipeptide

Lanthipeptides: J7E20_RS10245_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SDA PMT+TPTTITIPISLAGCPTTKCASIVSPCND

1

SDAAPMTITPTTITIPISLAGCPTTKCASIVSPCND

36

with 60 more sequence matches

Only the first 10 are displayed here.

66.7%

NZ_JAMDLZ010000027.1:

Lanthipeptides: M5W82_RS15520_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP T+TIPISLAGCPTTKCASIVSPC

8

TPLTVTIPISLAGCPTTKCASIVSPCKG

35

63.9%

NZ_WIXN01000006.1and 1 other:

NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide

Lanthipeptides: GHD25_RS06900_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPC

34

DATP T PTTI IP+SLA CPTT C S SPC

1

EDATPDT-HPTTI-IPVSLAVCPTTTCRSFSSPC

32

63.2%

NZ_AUCI01000015.1and 1 other:

NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide

Lanthipeptides: G475_RS0114655_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SD P + TT+TIPIS GCPTTKCAS+V PCND

3

SDQQPASHPTTTVTIPISAWGCPTTKCASVVEPCND

38

63.2%

NZ_FOXD01000022.1and 1 other:

NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide

Lanthipeptides: BM124_RS15255_lanthipeptide

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SD P + TT+TIPIS GCPTTKCAS+V PCND

3

SDQQPASHPTTTVTIPISAWGCPTTKCASVVKPCND

38

61.1%

NZ_CP063142.1and 5 others:

NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide

Lanthipeptides: HPB58_RS21455_lanthipeptide

12

TITIPISLAGCPTTKCASIVSPCND

36

T+TIPISLA CPTT+CASIVSPCND

8

TVTIPISLAACPTTQCASIVSPCND

32

61.1%

NZ_LT745762.1and 1 other:

NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide

Lanthipeptides: B2C77_RS21505_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP TI IP+SLA CPTTKCAS+V PCND

7

TPATI-IPVSLAICPTTKCASVVKPCND

33

58.3%

NZ_BOSN01000007.1and 3 others:

NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide

Lanthipeptides: KJS43_RS18000_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP TI IP+SLA CPTTKCAS+V PCN

7

TPATI-IPVSLAICPTTKCASVVKPCNG

33

58.3%

NZ_BQME02000001.1and 3 others:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide

Lanthipeptides: MFF31_RS04090_lanthipeptide

12

TITIPISLAGCPTTKCASIVSPCN

35

TI IPISLA CPTT+CASIVSPCN

6

TIIIPISLAACPTTRCASIVSPCN

29

55.6%

NZ_BQME02000001.1and 1 other:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04085_lanthipeptide

Lanthipeptides: MFF31_RS04085_lanthipeptide

12

TITIPISLAGCPTTKCASIVSPCN

35

TI IPISLA CPTT+CASIVS CN

6

TIIIPISLAACPTTRCASIVSSCN

29

55.6%

NZ_KQ040792.1and 1 other:

NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide

Lanthipeptides: WH45_RS23705_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP TI IP+SLA CPTT+CASIV CN

8

TPATI-IPVSLAICPTTRCASIVESCNG

34

MIBiG 4.0 matches for C6354_RS18855

24.3%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

13

ITIPISLAGCPTTKCAS

29

+ + +S A CPTTKC S

19

VAVGVSAAFCPTTKCTS

35

19.4%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

22

CPTTKCAS

29

CPTTKC S

17

CPTTKCTS

24

C6354_RS18860

Leader:

MKKEFLALELMTEEELKELAGG

Core:

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

Core with dehydrations:

DhaEADhbPMDhbVDhbPDhbDhbIDhbIPIDhaLAGCysPDhbDhbKCysADhaIVDhaPCysND

antiSMASH-DB 4.0 matches for C6354_RS18860

100.0%

NC_023073.1and 71 others:

NC_023073.1 Lanthipeptides: U722_RS19990_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide

Lanthipeptides: U722_RS19990_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

97.2%

NC_023073.1and 71 others:

NC_023073.1 Lanthipeptides: U722_RS19995_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide

Lanthipeptides: U722_RS19995_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

S+ATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

1

SDATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

97.2%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10240_lanthipeptide

Lanthipeptides: J7E20_RS10240_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

SEATPMT+TPTTITIPISLAGCPTTKCASIVSPCND

1

SEATPMTITPTTITIPISLAGCPTTKCASIVSPCND

36

with 60 more sequence matches

Only the first 10 are displayed here.

91.7%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10245_lanthipeptide

Lanthipeptides: J7E20_RS10245_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

S+A PMT+TPTTITIPISLAGCPTTKCASIVSPCND

1

SDAAPMTITPTTITIPISLAGCPTTKCASIVSPCND

36

66.7%

NZ_JAMDLZ010000027.1:

Lanthipeptides: M5W82_RS15520_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP T+TIPISLAGCPTTKCASIVSPC

8

TPLTVTIPISLAGCPTTKCASIVSPCKG

35

63.9%

NZ_KQ040792.1and 1 other:

NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide

Lanthipeptides: WH45_RS23705_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCN

35

+E+TP TP TI IP+SLA CPTT+CASIV CN

1

AESTP-NGTPATI-IPVSLAICPTTRCASIVESCN

33

61.1%

NZ_CP063142.1and 5 others:

NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide

Lanthipeptides: HPB58_RS21455_lanthipeptide

12

TITIPISLAGCPTTKCASIVSPCND

36

T+TIPISLA CPTT+CASIVSPCND

8

TVTIPISLAACPTTQCASIVSPCND

32

61.1%

NZ_LT745762.1and 1 other:

NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide

Lanthipeptides: B2C77_RS21505_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP TI IP+SLA CPTTKCAS+V PCND

7

TPATI-IPVSLAICPTTKCASVVKPCND

33

61.1%

NZ_WIXN01000006.1and 1 other:

NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide

Lanthipeptides: GHD25_RS06900_lanthipeptide

2

EATPMTVTPTTITIPISLAGCPTTKCASIVSPC

34

+ATP T PTTI IP+SLA CPTT C S SPC

2

DATPDT-HPTTI-IPVSLAVCPTTTCRSFSSPC

32

60.5%

NZ_AUCI01000015.1and 1 other:

NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide

Lanthipeptides: G475_RS0114655_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

S+ P + TT+TIPIS GCPTTKCAS+V PCND

3

SDQQPASHPTTTVTIPISAWGCPTTKCASVVEPCND

38

60.5%

NZ_FOXD01000022.1and 1 other:

NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide

Lanthipeptides: BM124_RS15255_lanthipeptide

1

SEATPMTVTPTTITIPISLAGCPTTKCASIVSPCND

36

S+ P + TT+TIPIS GCPTTKCAS+V PCND

3

SDQQPASHPTTTVTIPISAWGCPTTKCASVVKPCND

38

58.3%

NZ_BOSN01000007.1and 3 others:

NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide

Lanthipeptides: KJS43_RS18000_lanthipeptide

9

TPTTITIPISLAGCPTTKCASIVSPCND

36

TP TI IP+SLA CPTTKCAS+V PCN

7

TPATI-IPVSLAICPTTKCASVVKPCNG

33

58.3%

NZ_BQME02000001.1and 3 others:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide

Lanthipeptides: MFF31_RS04090_lanthipeptide

12

TITIPISLAGCPTTKCASIVSPCN

35

TI IPISLA CPTT+CASIVSPCN

6

TIIIPISLAACPTTRCASIVSPCN

29

MIBiG 4.0 matches for C6354_RS18860

24.3%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

13

ITIPISLAGCPTTKCAS

29

+ + +S A CPTTKC S

19

VAVGVSAAFCPTTKCTS

35

19.4%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

22

CPTTKCAS

29

CPTTKC S

17

CPTTKCTS

24

C6354_RS06030

Leader:

MNEKMYRFAGDLREELEEISLS

Core:

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

Core with dehydrations:

EFDhaGGGGAEQRGIDhaQGNDGKLCysDhbLDhbWECysGLCysPDhbHDhbCysWCys

antiSMASH-DB 4.0 matches for C6354_RS06030

100.0%

NC_023073.1and 65 others:

NC_023073.1 Lanthipeptides: U722_RS06170_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptide

Lanthipeptides: U722_RS06170_lanthipeptide

1

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

1

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

97.4%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10220_lanthipeptide

Lanthipeptides: J7E20_RS10220_lanthipeptide

1

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTC+C

1

EFSGGGGAEQRGISQGNDGKLCTLTWECGLCPTHTCFC

38

86.8%

NZ_CP016371.1and 7 others:

NZ_CP016371.1 Lanthipeptides: A5891_RS06120_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptide

Lanthipeptides: A5891_RS06120_lanthipeptide

6

GGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

GGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

1

GGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

33

with 92 more sequence matches

Only the first 10 are displayed here.

71.1%

NZ_BQME02000001.1and 1 other:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04105_lanthipeptide

Lanthipeptides: MFF31_RS04105_lanthipeptide

8

AEQRGISQGNDGKLCTLTWECGLCPTHTC-WC

38

AEQRGISQGNDGK CTLTWEC +CPT TC WC

1

AEQRGISQGNDGKYCTLTWECSVCPTLTCFWC

32

68.4%

NZ_CP063142.1and 10 others:

NZ_CP063142.1 Lanthipeptides: HPB58_RS21475_lanthipeptideNZ_FOXX01000007.1 Lanthipeptides: BM012_RS26100_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptideNZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptideNZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptideNZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptideNZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptide

Lanthipeptides: HPB58_RS21475_lanthipeptide

8

AEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AEQRGISQGNDG CT+TWEC +CPTHTCWC

1

AEQRGISQGNDGHQCTITWECSICPTHTCWC

31

68.4%

NZ_FOXD01000022.1and 1 other:

NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15270_lanthipeptide

Lanthipeptides: BM124_RS15270_lanthipeptide

8

AEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AE RGISQGNDG CT+TWECG+CPTHTCWC

3

AEPRGISQGNDGDYCTITWECGMCPTHTCWC

33

68.4%

NZ_KQ040792.1and 1 other:

NZ_KQ040792.1 Lanthipeptides: WH45_RS23330_lanthipeptide

Lanthipeptides: WH45_RS23330_lanthipeptide

8

AEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AE +G+SQGNDGK+CTLTWECGLCPTHTC+C

1

AEVQGLSQGNDGKVCTLTWECGLCPTHTCFC

31

65.8%

NZ_BOSN01000007.1and 3 others:

NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18005_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptide

Lanthipeptides: KJS43_RS18005_lanthipeptide

7

GAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AE GISQGNDGK CT+TWEC +CPTHTCWC

1

AAEPMGISQGNDGKYCTITWECSICPTHTCWC

32

65.8%

NZ_LT745762.1and 1 other:

NZ_LT745762.1 Lanthipeptides: B2C77_RS00795_lanthipeptide

Lanthipeptides: B2C77_RS00795_lanthipeptide

7

GAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AE GISQGNDGK CT+TWEC +CPTHTCWC

1

AAEPMGISQGNDGKWCTVTWECSICPTHTCWC

32

63.2%

NZ_AUCI01000015.1and 1 other:

NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114640_lanthipeptide

Lanthipeptides: G475_RS0114640_lanthipeptide

6

GGAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

E RG+SQGNDG CT+TWECG+CPTHTCWC

1

ADVETRGLSQGNDGDYCTITWECGMCPTHTCWC

33

63.2%

NZ_CP101913.1and 1 other:

NZ_CP101913.1 Lanthipeptides: NP440_RS09135_lanthipeptide

Lanthipeptides: NP440_RS09135_lanthipeptide

7

GAEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

AE GIS+ NDGK CTLTWEC +CPTHTCWC

1

AAEPMGISEDNDGKYCTLTWECSICPTHTCWC

32

63.2%

NZ_KV917378.1and 1 other:

NZ_KV917378.1 Lanthipeptides: BK581_RS07320_lanthipeptide

Lanthipeptides: BK581_RS07320_lanthipeptide

8

AEQRGISQGNDGKLCTLTWECGLCPTHTCWC

38

A+ +GISQGNDGK CT+TWEC +CPTHTCWC

1

ADVQGISQGNDGKYCTITWECSICPTHTCWC

31

55.3%

NZ_CP040417.1and 7 others:

NZ_CP040417.1 Lanthipeptides: FE328_RS09040_lanthipeptideNZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptideNZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptideNZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptideNZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide

Lanthipeptides: FE328_RS09040_lanthipeptide

5

GGGAEQRGISQGNDGKLCTLTWECGLCPTHTCW

37

G G R +S+GN GK+CTLTWECG+CP+HTC+

1

GVGKWIRKLSKGNTGKVCTLTWECGICPSHTCF

33

MIBiG 4.0 matches for C6354_RS06030

23.7%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

16

GNDGKLCTLTWEC

28

GN G CTLT EC

11

GNKGAYCTLTVEC

23

23.7%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

16

GNDGKLCTLTWEC

28

GN+G CTLT EC

13

GNNGGWCTLTKEC

25

15.8%

BGC0000580.3 (EGD17355.1):

Lasso peptide: xanthomonin II or xanthomonin I

6

GGAEQRGISQ

15

GG GISQ

10

GGITTLGISQ

19

with 1 more sequence matches

12.8%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

22

CTLTWEC

28

CTL+ EC

28

CTLSKEC

34

allorf_337625_337702

Leader:

MRIHSIFIRMQGLYA

Core:

QVICPTNATY

Core with dehydrations:

QVICysPDhbNADhbY

antiSMASH-DB 4.0 matches for allorf_337625_337702

100.0%

NZ_CP016371.1and 22 others:

NZ_CP017775.1 Lanthipeptides: allorf_1370160_1370237_lanthipeptideNZ_CP018295.1 Lanthipeptides: allorf_1230930_1231007_lanthipeptideNZ_CP023075.1 Lanthipeptides: allorf_1287116_1287193_lanthipeptideNZ_CP027429.1 Lanthipeptides: allorf_2639262_2639339_lanthipeptideNZ_CP027429.1 Lanthipeptides: allorf_2639262_2639339_lanthipeptideNZ_CP033967.1 Lanthipeptides: allorf_3538116_3538193_lanthipeptideNZ_CP033967.1 Lanthipeptides: allorf_3538116_3538193_lanthipeptideNZ_CP044133.1 Lanthipeptides: allorf_1292127_1292204_lanthipeptideNZ_CP044444.1 Lanthipeptides: allorf_2627237_2627314_lanthipeptideNZ_CP048002.1 Lanthipeptides: allorf_3123788_3123865_lanthipeptideNZ_CP059405.1 Lanthipeptides: allorf_3176215_3176292_lanthipeptideNZ_CP059495.1 Lanthipeptides: allorf_1278377_1278454_lanthipeptideNZ_CP064091.1 Lanthipeptides: allorf_3836090_3836167_lanthipeptideNZ_CP083716.1 Lanthipeptides: allorf_110856_110933_lanthipeptideNZ_CP092110.1 Lanthipeptides: allorf_0704361_0704438_lanthipeptideNZ_CP092110.1 Lanthipeptides: allorf_0704361_0704438_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: allorf_101096_101173_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: allorf_101096_101173_lanthipeptideNZ_KB206086.1 Lanthipeptides: allorf_0474373_0474450_lanthipeptideNZ_KN050798.1 Lanthipeptides: allorf_0351480_0351557_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: allorf_337625_337702_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: allorf_337625_337702_lanthipeptide

Lanthipeptides: allorf_1210473_1210550_lanthipeptide

1

QVICPTNATY

10

QVICPTNATY

1

QVICPTNATY

10

allorf_344018_344200

Leader:

MKGGEIWNMKKNFSALYETSEQELKELVGG

Core:

QNSVSITTYPITNHICPTITVGCACPQRQV

Core with dehydrations:

QNDhaVDhaIDhbDhbYPIDhbNHICysPDhbIDhbVGCysACysPQRQV

antiSMASH-DB 4.0 matches for allorf_344018_344200

100.0%

NZ_CP016371.1and 25 others:

NZ_CP017775.1 Lanthipeptides: allorf_1362373_1362555_lanthipeptideNZ_CP018295.1 Lanthipeptides: allorf_1224462_1224620_lanthipeptideNZ_CP023075.1 Lanthipeptides: allorf_1280618_1280800_lanthipeptideNZ_CP027429.1 Lanthipeptides: allorf_2645650_2645832_lanthipeptideNZ_CP027429.1 Lanthipeptides: allorf_2645650_2645832_lanthipeptideNZ_CP033967.1 Lanthipeptides: allorf_3544503_3544661_lanthipeptideNZ_CP033967.1 Lanthipeptides: allorf_3544503_3544661_lanthipeptideNZ_CP035393.1 Lanthipeptides: allorf_1361512_1361694_lanthipeptideNZ_CP044133.1 Lanthipeptides: allorf_1285659_1285817_lanthipeptideNZ_CP044444.1 Lanthipeptides: allorf_2620740_2620922_lanthipeptideNZ_CP048002.1 Lanthipeptides: allorf_3117293_3117475_lanthipeptideNZ_CP059405.1 Lanthipeptides: allorf_3169717_3169899_lanthipeptideNZ_CP059495.1 Lanthipeptides: allorf_1271882_1272064_lanthipeptideNZ_CP064091.1 Lanthipeptides: allorf_3829595_3829777_lanthipeptideNZ_CP083716.1 Lanthipeptides: allorf_104358_104540_lanthipeptideNZ_CP092110.1 Lanthipeptides: allorf_0710754_0710936_lanthipeptideNZ_CP092110.1 Lanthipeptides: allorf_0710754_0710936_lanthipeptideNZ_CP116013.1 Lanthipeptides: allorf_0410910_0411092_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: allorf_107486_107668_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: allorf_107486_107668_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: allorf_050414_050596_lanthipeptideNZ_KB206086.1 Lanthipeptides: allorf_0467875_0468057_lanthipeptideNZ_KN050798.1 Lanthipeptides: allorf_0345012_0345170_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: allorf_344018_344200_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: allorf_344018_344200_lanthipeptide

Lanthipeptides: allorf_1203980_1204162_lanthipeptide

1

QNSVSITTYPITNHICPTITVGCACPQRQV

30

QNSVSITTYPITNHICPTITVGCACPQRQV

1

QNSVSITTYPITNHICPTITVGCACPQRQV

30

93.3%

NC_023073.1and 18 others:

NZ_CP010556.1 Lanthipeptides: allorf_1170865_1171047_lanthipeptideNZ_CP016395.1 Lanthipeptides: allorf_1266893_1267075_lanthipeptideNZ_CP023133.1 Lanthipeptides: allorf_0800979_0801161_lanthipeptideNZ_CP025341.1 Lanthipeptides: allorf_1207246_1207428_lanthipeptideNZ_CP028440.1 Lanthipeptides: allorf_1169247_1169429_lanthipeptideNZ_CP028440.1 Lanthipeptides: allorf_1169247_1169429_lanthipeptideNZ_CP031694.1 Lanthipeptides: allorf_3757607_3757789_lanthipeptideNZ_CP031694.1 Lanthipeptides: allorf_3757607_3757789_lanthipeptideNZ_CP065790.1 Lanthipeptides: allorf_1228836_1229018_lanthipeptideNZ_CP072310.1 Lanthipeptides: allorf_3340146_3340328_lanthipeptideNZ_CP074685.1 Lanthipeptides: allorf_1220760_1220942_lanthipeptideNZ_CP075054.1 Lanthipeptides: allorf_2702843_2703025_lanthipeptideNZ_CP075054.1 Lanthipeptides: allorf_2702843_2703025_lanthipeptideNZ_CP088300.1 Lanthipeptides: allorf_1174611_1174793_lanthipeptideNZ_CP090905.1 Lanthipeptides: allorf_1201177_1201359_lanthipeptideNZ_CP094618.1 Lanthipeptides: allorf_1135121_1135303_lanthipeptideNZ_CP119675.1 Lanthipeptides: allorf_2182837_2183019_lanthipeptideNZ_LN999829.1 Lanthipeptides: allorf_1186077_1186259_lanthipeptide

Lanthipeptides: allorf_1238739_1238921_lanthipeptide

1

QNSVSITTYPITNHICPTITVGCACPQRQV

30

QNSVSITT PITNH+CPTITVGCACPQRQV

1

QNSVSITTIPITNHVCPTITVGCACPQRQV

30

66.7%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10235_lanthipeptide

Lanthipeptides: J7E20_RS10235_lanthipeptide

1

QNSVSITTYPITNHICPTITVGCACPQRQV

30

QN +SITT P T H+C T+TVGCACPQ+Q+

1

QNLISITTIPFT-HLCATVTVGCACPQKQI

29

with 3 more sequence matches

23.5%

NZ_CP048048.1and 2 others:

NZ_CP048050.1 Lanthipeptides: GW570_RS15170_lanthipeptideNZ_CP088267.1 Lanthipeptides: LRE50_RS16510_lanthipeptide

Lanthipeptides: GW571_RS15175_lanthipeptide

8

TYPITNHICPTITVGCACPQRQ

29

T+ +T +C TI AC Q

8

TFKLTVKVCRTIITTTACGSTQ

29

20.0%

NZ_JANIOB010000033.1:

Lanthipeptides: NQ113_RS28010_lanthipeptide

11

ITNHICPTI

19

TN +CPTI

15

FTNRLCPTI

23

15.8%

NZ_KB907258.1:

Lanthipeptides: G358_RS0114910_lanthipeptide

2

NSVSITTYPITNHICPTIT

20

NS+ I+ Y + CP++

6

NSIRISIYKCLSLFCPSVA

24

MIBiG 4.0 matches for allorf_344018_344200

13.3%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

18

TITVGC

23

T+TV C

18

TLTVEC

23

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.38 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.28 out of 27.78

Confidence: strong

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 24.65 out of 24.78

Confidence: strong

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05

Confidence: medium

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.57 out of 20.01

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.27 out of 23.79

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.96 out of 28.19

Confidence: medium

Additional weak hits (4):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.13 out of 30.22

Confidence: weak

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 20.85 out of 30.22

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.99 out of 29.65

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.46 out of 30.11

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

C6354_RS18850 - Class II

Cleavage pHMM score: -7.30

RODEO score: 0

Monoisotopic mass: 4023.2 Da

Molecular weight: 4025.7 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 4043.7 Da N = 1

C6354_RS18855 - Class II

Cleavage pHMM score: 3.30

RODEO score: 0

Monoisotopic mass: 3389.7 Da

Molecular weight: 3391.9 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3409.9 Da N = 1; 3427.9 Da N = 2; 3446.0 Da N = 3; 3464.0 Da N = 4; 3482.0 Da N = 5; 3500.0 Da N = 6; 3518.0 Da N = 7; 3536.1 Da N = 8; 3554.1 Da N = 9

C6354_RS18860 - Class II

Cleavage pHMM score: 3.30

RODEO score: 0

Monoisotopic mass: 3403.7 Da

Molecular weight: 3405.9 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3423.9 Da N = 1; 3442.0 Da N = 2; 3460.0 Da N = 3; 3478.0 Da N = 4; 3496.0 Da N = 5; 3514.0 Da N = 6; 3532.1 Da N = 7; 3550.1 Da N = 8; 3568.1 Da N = 9

C6354_RS06030 - Class II

Cleavage pHMM score: -4.60

RODEO score: 0

Monoisotopic mass: 3892.7 Da

Molecular weight: 3895.3 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 3913.3 Da N = 1

allorf_330876_330977 - Class II

Cleavage pHMM score: -5.60

RODEO score: 0

Monoisotopic mass: 1601.8 Da

Molecular weight: 1602.8 Da

Number of bridges: 1

allorf_335356_335517 - Class II

Cleavage pHMM score: -2.00

RODEO score: 0

Monoisotopic mass: 3921.0 Da

Molecular weight: 3923.7 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3941.7 Da N = 1

allorf_337625_337702 - Class II

Cleavage pHMM score: -5.60

RODEO score: 0

Monoisotopic mass: 1072.5 Da

Molecular weight: 1073.2 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1091.2 Da N = 1

allorf_344018_344200 - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 3117.6 Da

Molecular weight: 3119.6 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3137.6 Da N = 1; 3155.6 Da N = 2; 3173.6 Da N = 3; 3191.6 Da N = 4

C6354_RS18855 - Class II

Cleavage pHMM score: 3.30

RODEO score: 0

Monoisotopic mass: 3389.7 Da

Molecular weight: 3391.9 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3409.9 Da N = 1; 3427.9 Da N = 2; 3446.0 Da N = 3; 3464.0 Da N = 4; 3482.0 Da N = 5; 3500.0 Da N = 6; 3518.0 Da N = 7; 3536.1 Da N = 8; 3554.1 Da N = 9

C6354_RS18860 - Class II

Cleavage pHMM score: 3.30

RODEO score: 0

Monoisotopic mass: 3403.7 Da

Molecular weight: 3405.9 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3423.9 Da N = 1; 3442.0 Da N = 2; 3460.0 Da N = 3; 3478.0 Da N = 4; 3496.0 Da N = 5; 3514.0 Da N = 6; 3532.1 Da N = 7; 3550.1 Da N = 8; 3568.1 Da N = 9

C6354_RS06030 - Class II

Cleavage pHMM score: -4.60

RODEO score: 0

Monoisotopic mass: 3892.7 Da

Molecular weight: 3895.3 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 3913.3 Da N = 1

allorf_337625_337702 - Class II

Cleavage pHMM score: -5.60

RODEO score: 0

Monoisotopic mass: 1072.5 Da

Molecular weight: 1073.2 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 1091.2 Da N = 1

allorf_344018_344200 - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 3117.6 Da

Molecular weight: 3119.6 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3137.6 Da N = 1; 3155.6 Da N = 2; 3173.6 Da N = 3; 3191.6 Da N = 4

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
ArgR	Regulator of arginine biosynthesis genes
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
IolR	Regulator of the inositol catabolism
LexA variant 2	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
ZuR variant 1	Zinc-responsive repressor

NZ_PVRO01000002.1 - Region 3 - terpene

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Location: 524,118 - 544,858 nt. (total: 20,741 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

C6354_RS07010: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

Transferases: aminotransferase

C6354_RS06995: aminotransferase

smcogs: SMCOG1019: aminotransferase

Hydrolases: hydrolase

C6354_RS07035: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002458.3	0.49	NRPS	alazopeptin	Streptacidiphilus griseoplanus
BGC0000885.3	0.47	other (other)	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0000846.5	0.44	other (other)	tabtoxin	Pseudomonas syringae
BGC0001374.5	0.42	other (other)	thienodolin	Streptomyces albogriseolus
BGC0001880.3	0.41	ribosomal	scytodecamide	Scytonema sp. UIC 10036
BGC0001488.3	0.38	other (other)	4-formylaminooxyvinylglycine	Pseudomonas fluorescens WH6
BGC0000720.3	0.35	saccharide	tobramycin	Streptoalloteichus tenebrarius
BGC0002285.2	0.35	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0001810.3	0.35	PKS	trehangelin	Polymorphospora rubra
BGC0001735.5	0.35	other (other)	pentostatine, vidarabine	Streptomyces antibioticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002458.3	0.49	NRPS	alazopeptin	Streptacidiphilus griseoplanus
BGC0000885.3	0.47	other (other)	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0000846.5	0.44	other (other)	tabtoxin	Pseudomonas syringae
BGC0001374.5	0.42	other (other)	thienodolin	Streptomyces albogriseolus
BGC0001880.3	0.41	ribosomal	scytodecamide	Scytonema sp. UIC 10036
BGC0001488.3	0.38	other (other)	4-formylaminooxyvinylglycine	Pseudomonas fluorescens WH6
BGC0000720.3	0.35	saccharide	tobramycin	Streptoalloteichus tenebrarius
BGC0002285.2	0.35	ribosomal	aborycin	Streptomyces sp. ZS0098
BGC0001810.3	0.35	PKS	trehangelin	Polymorphospora rubra
BGC0001735.5	0.35	other (other)	pentostatine, vidarabine	Streptomyces antibioticus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene		PSPP	C30	acyclic	PP
triterpene	C30 carotenoid	diapophytoene	C30	acyclic	none
triterpene		squalene	C30	acyclic	none
tetraterpene	C40 carotenoid	phytoene	C40	acyclic	none
triterpene		hydroxysqualene	C30	acyclic	OH

Genes with terpene domains:

C6354_RS07030: PT_phytoene_like

Domain 1 (3 - 242): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → PSPP; FPP → diapophytoene; FPP → squalene; GGPP → phytoene; PSPP → hydroxysqualene

Transcription Factor Binding Sites

Binding sites found:

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 23.16 out of 26.33

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.88 out of 27.78

Confidence: medium

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.10 out of 26.85

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.27 out of 28.19

Confidence: medium

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 26.99 out of 35.63

Confidence: medium

Additional weak hits (6):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.61 out of 30.22

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.44 out of 31.73

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.16 out of 26.06

Confidence: weak

MexT

Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.38 out of 21.84

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.91 out of 32.74

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.48 out of 30.25

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
PP	Diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
NrtR	NAD synthesis repressor
RutR	Regulator of the pyrimidine and purine metabolism
ZuR variant 1	Zinc-responsive repressor

NZ_PVRO01000002.1 - Region 4 - PKS-like

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Location: 627,553 - 668,797 nt. (total: 41,245 nt) Show pHMM detection rules used

PKS-like: (t2pks2 or ksIII)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

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KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

C6354_RS07680: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acyltransferase aminotransferase

C6354_RS07635: aminotransferase

smcogs: SMCOG1019: aminotransferase

C6354_RS07650: acyltransferase

smcogs: SMCOG1141: acyltransferase

Hydrolases: deacetylase

C6354_RS07590: polysaccharide deacetylase

smcogs: SMCOG1235: polysaccharide deacetylase

Ligases: synthase

C6354_RS07630: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Translocases: permease

C6354_RS07675: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002276.2	0.52	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001928.2	0.46	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0002294.3	0.44	other (other)	streptozotocin	Streptomyces achromogenes subsp. streptozoticus
BGC0000205.3	0.43	PKS	bryostatin	Candidatus Endobugula sertula
BGC0002150.2	0.42	ribosomal	triculamin	Streptomyces triculaminicus
BGC0002151.2	0.42	ribosomal	alboverticillin	Streptomyces griseocarneus
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000623.3	0.42	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001206.5	0.42	other (other)	indolmycin	Streptomyces griseus subsp. griseus
BGC0000551.5	0.42	ribosomal	SapB	Streptomyces coelicolor A3(2)

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002276.2	0.52	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001928.2	0.46	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0002294.3	0.44	other (other)	streptozotocin	Streptomyces achromogenes subsp. streptozoticus
BGC0000205.3	0.43	PKS	bryostatin	Candidatus Endobugula sertula
BGC0002150.2	0.42	ribosomal	triculamin	Streptomyces triculaminicus
BGC0002151.2	0.42	ribosomal	alboverticillin	Streptomyces griseocarneus
BGC0002306.2	0.42	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000623.3	0.42	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001206.5	0.42	other (other)	indolmycin	Streptomyces griseus subsp. griseus
BGC0000551.5	0.42	ribosomal	SapB	Streptomyces coelicolor A3(2)

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.49 out of 25.88

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.50 out of 23.79

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.52 out of 26.06

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 25.91 out of 27.55

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.88 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.01 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.81 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.75 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.99 out of 26.06

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.83 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.27 out of 28.19

Confidence: medium

Additional weak hits (13):

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.59 out of 30.11

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.41 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.75 out of 26.06

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.28 out of 28.14

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.34 out of 30.25

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.97 out of 28.14

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.46 out of 26.06

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.28 out of 28.14

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.22 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.15 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.48 out of 29.38

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.02 out of 28.14

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.32 out of 33.14

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

TFBS Finder

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM	Regulator of nitrogen-fixation genes
IolR	Regulator of the inositol catabolism
MogR	Repressor of flagellar motility genes
PsrA	Oleic acid responsive regulator
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_PVRO01000003.1 - Region 1 - terpene-precursor

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Location: 135,474 - 156,364 nt. (total: 20,891 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: carboxylase

C6354_RS09025: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase

C6354_RS09055: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

C6354_RS09060: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0000638.3	0.37	terpene	carotenoid	Pantoea ananatis
BGC0000640.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC404

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0000638.3	0.37	terpene	carotenoid	Pantoea ananatis
BGC0000640.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC404

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

C6354_RS09055: PT_FPPS_like

Domain 1 (33 - 296): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.59 out of 30.25

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.14 out of 27.78

Confidence: medium

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.81 out of 29.25

Confidence: medium

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
SypG	Regulator of biofilm formation and host colonization

NZ_PVRO01000003.1 - Region 2 - transAT-PKS

Download region GenBank file

Download region SVG

Location: 179,680 - 261,187 nt. (total: 81,508 nt) Show pHMM detection rules used

transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

C6354_RS09275: 3-hydroxyisobutyrate dehydrogenase

smcogs: SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

C6354_RS09300: NADH:flavin oxidoreductase/NADH oxidase

smcogs: SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

C6354_RS09345: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

C6354_RS09350: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

C6354_RS09355: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

C6354_RS09365: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

C6354_RS09370: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

C6354_RS09395: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

C6354_RS09475: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

Transferases: acylase transferase

C6354_RS09250: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

C6354_RS09325: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: deacetylase hydrolase

C6354_RS09255: acetylornithine deacetylase

smcogs: SMCOG1247: acetylornithine deacetylase

C6354_RS09390: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

Lyases: hydratase

C6354_RS09380: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase

C6354_RS09340: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

C6354_RS09360: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

C6354_RS09375: hydroxymethylglutaryl-CoA synthase

smcogs: SMCOG1043: hydroxymethylglutaryl-CoA synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000176.5	0.73	PKS	difficidin	Bacillus velezensis FZB42
BGC0001164.3	0.62	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.61	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001254.3	0.61	PKS	ACT-Toxin II	Alternaria alternata
BGC0000174.5	0.60	PKS	bryostatin	Candidatus Endobugula sertula
BGC0002056.3	0.57	NRPS, PKS	peloruside A	sponge metagenome
BGC0001795.3	0.53	PKS	swinholide A	Nostoc sp. UHCC 0450
BGC0000067.5	0.53	PKS	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000205.3	0.52	PKS	bryostatin	Candidatus Endobugula sertula
BGC0001201.3	0.52	terpene	eremophilene	Sorangium cellulosum So ce56

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000176.5	0.73	PKS	difficidin	Bacillus velezensis FZB42
BGC0001164.3	0.62	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.61	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001254.3	0.61	PKS	ACT-Toxin II	Alternaria alternata
BGC0000174.5	0.60	PKS	bryostatin	Candidatus Endobugula sertula
BGC0002056.3	0.57	NRPS, PKS	peloruside A	sponge metagenome
BGC0001795.3	0.53	PKS	swinholide A	Nostoc sp. UHCC 0450
BGC0000067.5	0.53	PKS	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000205.3	0.52	PKS	bryostatin	Candidatus Endobugula sertula
BGC0001201.3	0.52	terpene	eremophilene	Sorangium cellulosum So ce56

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.22 out of 18.57

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.92 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.19 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.89 out of 27.78

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 23.96 out of 24.78

Confidence: strong

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.30 out of 25.31

Confidence: medium

Additional weak hits (9):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.08 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.45 out of 26.06

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.61 out of 30.25

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 21.46 out of 30.97

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.34 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.26 out of 26.06

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 22.13 out of 30.97

Confidence: weak

CopR

Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 26.71 out of 30.97

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.89 out of 32.93

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 2, location 179679 - 261187:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-ccmal - ccmal - ohmal - ccmal) + (ohmal - mal) + (Me-ccmal) + (mal)
Non-colinear ordering:: C6354_RS09350 + C6354_RS09355 + C6354_RS09360 + C6354_RS09365

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

C6354_RS09325: mal

PKS_AT (4..281): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 87.7
inactive: 30.9
Methoxymalonyl-CoA: 29.3
Methylmalonyl-CoA: 21.7
Propionyl-CoA: 16.5
2-Methylbutyryl-CoA: 15.4
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

C6354_RS09340: X

AMP-binding (15..363): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: ALLLHIGGINTAPATYGTEKQTYGLTELGIFSTK
Nearest Stachelhaus code(s):: 2,3-dohHda IGNPTGTIMK (74% 8Å match)
Stachelhaus code match:: 90% (moderate)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CatR	H2O2-responsive repressor
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 2	Repressor of DNA damage response
ToxT	Regulator of MSHA biosynthesis

NZ_PVRO01000005.1 - Region 1 - NRPS,transAT-PKS-like

Download region GenBank file

Download region SVG

Location: 1 - 60,230 nt. (total: 60,230 nt) Show pHMM detection rules used

Region on contig edge.

transAT-PKS-like: cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS) and not PKS_AT)
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxygenase

C6354_RS11630: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Hydrolases: protease

C6354_RS11650: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Ligases: ligase synthase

C6354_RS11615: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

C6354_RS11620: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

C6354_RS11625: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001244.3	0.55	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001276.3	0.55	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.3	0.55	PKS	asperlactone	Aspergillus ochraceus
BGC0002175.3	0.54	PKS	YWA1	Aspergillus oryzae RIB40
BGC0000107.3	0.54	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002191.2	0.54	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0000041.3	0.54	PKS	oronofacic acid	Pseudomonas syringae
BGC0002154.2	0.53	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.53	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001254.3	0.52	PKS	ACT-Toxin II	Alternaria alternata

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001244.3	0.61	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001276.3	0.61	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.3	0.61	PKS	asperlactone	Aspergillus ochraceus
BGC0002175.3	0.61	PKS	YWA1	Aspergillus oryzae RIB40
BGC0000107.3	0.61	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002191.2	0.61	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0000041.3	0.60	PKS	oronofacic acid	Pseudomonas syringae
BGC0002154.2	0.60	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.60	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001254.3	0.60	PKS	ACT-Toxin II	Alternaria alternata

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.47 out of 21.55

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.29 out of 27.78

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 24.10 out of 24.78

Confidence: strong

Additional weak hits (8):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.04 out of 30.25

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.39 out of 30.25

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.54 out of 36.54

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 20.38 out of 28.14

Confidence: weak

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.53 out of 30.25

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.62 out of 32.93

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.08 out of 39.62

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 60230:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (ohmal - mal) + (Ala - ccmal - ccmal - Me-ccmal) + (mal - mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

C6354_RS11620: Ala

Search NORINE for peptide: strict or relaxed

AMP-binding (492..896): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: TFLTFDVSISEGNFMVAGEENIYGPTETSIYAAY
Nearest Stachelhaus code(s):: Ala DVSNMAIIYK (88% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 2	Repressor of DNA damage response
ToxT	Regulator of MSHA biosynthesis

NZ_PVRO01000005.1 - Region 2 - NRPS,betalactone,transAT-PKS

Download region GenBank file

Download region SVG

Location: 115,278 - 203,088 nt. (total: 87,811 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
betalactone: (HMGL-like and AMP-binding)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

C6354_RS12125: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

C6354_RS12140: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

C6354_RS12205: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

C6354_RS12225: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

C6354_RS12300: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Transferases: acylase aminotransferase carboxylase kinase transferase

C6354_RS12120: PfkB domain protein

smcogs: SMCOG1276: PfkB domain protein

C6354_RS12200: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

C6354_RS12245: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

C6354_RS12260: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

C6354_RS12270: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

C6354_RS12290: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Lyases: hydratase

C6354_RS12275: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase

C6354_RS12185: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

C6354_RS12190: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

C6354_RS12195: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

C6354_RS12240: 8-amino-7-oxononanoate synthase

smcogs: SMCOG1109: 8-amino-7-oxononanoate synthase

C6354_RS12280: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

C6354_RS12295: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

C6354_RS12315: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

C6354_RS12320: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001090.5	1.50	NRPS, PKS	bacillomycin D	Bacillus velezensis FZB42
BGC0001833.4	1.49	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	1.47	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001128.4	1.45	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	1.44	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001825.4	1.43	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001098.5	1.42	NRPS, PKS	iturin	Bacillus subtilis
BGC0002286.3	1.42	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	1.40	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0001135.5	1.38	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001090.5	0.88	NRPS, PKS	bacillomycin D	Bacillus velezensis FZB42
BGC0001098.5	0.84	NRPS, PKS	iturin	Bacillus subtilis
BGC0000402.4	0.80	NRPS	paenilarvin A, paenilarvin B, paenilarvin C	Paenibacillus larvae subsp. larvae DSM 25430
BGC0001103.5	0.77	NRPS, PKS	mycosubtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001095.5	0.76	NRPS	fengycin	Bacillus velezensis FZB42
BGC0001833.4	0.75	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0002135.2	0.75	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001128.4	0.74	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4	0.73	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0002075.3	0.73	NRPS	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 18.15 out of 18.46

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.21 out of 27.78

Confidence: medium

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.29 out of 27.55

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 20.32 out of 20.97

Confidence: strong

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 22.20 out of 24.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.82 out of 26.06

Confidence: medium

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.44 out of 32.93

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.67 out of 26.06

Confidence: medium

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.67 out of 20.01

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.83 out of 28.19

Confidence: medium

Additional weak hits (11):

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.61 out of 30.11

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.22 out of 28.14

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.65 out of 26.06

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.06 out of 29.38

Confidence: weak

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.01 out of 24.78

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.15 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.52 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.45 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.46 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.74 out of 26.06

Confidence: weak

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.44 out of 20.47

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 2, location 115277 - 203088:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Tyr) + (Ile) + (fatty_acid - mal - Asn - D-Tyr) + (D-Asn - Pro - Glu - D-Ser) + (Thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 115277 - 192527:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (fatty_acid - mal - Asn - D-Tyr) + (D-Asn - Pro - Glu - D-Ser) + (Thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 175442 - 203088:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Tyr) + (Ile)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

C6354_RS12185: Ser - Thr

Search NORINE for peptide: strict or relaxed

AMP-binding (267..674): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: RWMTFDVSVWEWHFFASGEINLYGPTEATIDVSY
Nearest Stachelhaus code(s):: Ser DVWHFSLIDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1789..2188): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: LNNHFDFSVWEGNQIFGGEINMYGITETTVHVTY
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

C6354_RS12190: Tyr - Asn - Pro - Glu

Search NORINE for peptide: strict or relaxed

AMP-binding (268..662): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: SWKYFDAFILNGSTVVGGENNEYGPTENSVVSTF
Nearest Stachelhaus code(s):: Tyr DALSVGEVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1779..2174): Asn

nrpys: Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: YWASFDLTVTSTKLIVGGECNEYGPTETVVGCMI
Nearest Stachelhaus code(s):: Asn DLTKIGEVGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3286..3683): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: LDQAFDVCYQESFFITAGEHNHYGPSETHVVSTY
Nearest Stachelhaus code(s):: Pro DVQFIAHVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (4325..4732): Glu

nrpys: Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: gln (Gln)

Stachelhaus prediction details:

Stachelhaus sequence:: LGLAFDASVKQADGLIGGETNVYGPTETCVDASV
Nearest Stachelhaus code(s):: Glu DAKDLGVVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

C6354_RS12195: fatty_acid - Asn

Search NORINE for peptide: strict or relaxed

CAL_domain (36..478): fatty_acid

minowa: fatty_acid

Prediction, score:

fatty_acid: 620.1
NH2: 18.6
shikimic_acid: 0.0
Acetyl-CoA: 0.0
AHBA: 0.0

AMP-binding (2956..3351): Asn

nrpys: Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)

Stachelhaus prediction details:

Stachelhaus sequence:: YWASFDLTVTSTKLIVGGEFNEYGPTEAVVGCMI
Nearest Stachelhaus code(s):: Asn DLTKIGEVGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

C6354_RS12200: mal

PKS_AT (6..290): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 76.9
inactive: 33.0
Methoxymalonyl-CoA: 22.5
Methylmalonyl-CoA: 11.9
Propionyl-CoA: 10.3
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

C6354_RS12295: X

AMP-binding (12..445): X

nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: NNIVF-GCVLGAHGIMAGSTIAYGQTEASPVITQ
Nearest Stachelhaus code(s):: Z-ahmohOrn FGLHIASTCK (56% 8Å match); Ile DGLFIGIPVK (32% 8Å match)
Stachelhaus code match:: 60% (weak)

C6354_RS12315: Ile

Search NORINE for peptide: strict or relaxed

AMP-binding (473..866): Ile

nrpys: Ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: ile (Ile)

Stachelhaus prediction details:

Stachelhaus sequence:: LNSGFDAVTFEGFLYVGGEYNIYGPTENTTFSTF
Nearest Stachelhaus code(s):: Ile DAFFYGITFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

C6354_RS12320: Tyr

Search NORINE for peptide: strict or relaxed

AMP-binding (214..606): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: TWRFFDGFVTSTIITLAGEANEYGPTENSVATTA
Nearest Stachelhaus code(s):: Tyr DGTITAEVAK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
ArgR	Regulator of arginine biosynthesis genes
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM	Regulator of nitrogen-fixation genes
LexA variant 2	Repressor of DNA damage response
LexA variant 3	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes
RpoN	Regulator of nitrogen assimilation and virulence
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_PVRO01000006.1 - Region 1 - NRPS

Download region GenBank file

Download region SVG

Location: 1 - 28,131 nt. (total: 28,131 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase electron transfer oxidoreductase reductase

C6354_RS12375: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

C6354_RS12390: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

C6354_RS12395: flavodoxin

smcogs: SMCOG1134: flavodoxin

C6354_RS12400: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

C6354_RS12415: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

Ligases: synthase

C6354_RS12380: cobalamin synthesis protein/P47K family protein

smcogs: SMCOG1178: cobalamin synthesis protein/P47K family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.71	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.68	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0000342.4	0.68	NRPS	enniatin	Fusarium equiseti
BGC0001825.4	0.68	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001833.4	0.68	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.4	0.67	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.66	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.66	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.66	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0000307.4	0.65	NRPS	AbT1	Aureobasidium pullulans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002135.2	0.71	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0001135.5	0.68	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0000342.4	0.68	NRPS	enniatin	Fusarium equiseti
BGC0001825.4	0.68	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001833.4	0.68	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001132.4	0.67	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001128.4	0.66	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.66	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4	0.66	NRPS	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0000307.4	0.65	NRPS	AbT1	Aureobasidium pullulans

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.40 out of 20.97

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.88 out of 23.79

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.55 out of 29.38

Confidence: medium

Additional weak hits (6):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.84 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.40 out of 26.06

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 23.23 out of 36.54

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.74 out of 32.74

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.89 out of 29.38

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 22.50 out of 35.63

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 1, location 0 - 28131:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Glu - Leu)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

C6354_RS12325: Glu - Leu

Search NORINE for peptide: strict or relaxed

AMP-binding (465..867): Glu

nrpys: Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: gln (Gln)

Stachelhaus prediction details:

Stachelhaus sequence:: LSLAFDASVKQADGLIGGETNVYGPTETCVDASV
Nearest Stachelhaus code(s):: Glu DAKDLGVVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1511..1908): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: TNTSFDAFMFDGMIMFGGELHMYGPSESTVFATY
Nearest Stachelhaus code(s):: Leu DAFMMGMVFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
FuR variant 1	Ferric Uptake Regulator
IolR	Regulator of the inositol catabolism

NZ_PVRO01000006.1 - Region 2 - azole-containing-RiPP

Download region GenBank file

Download region SVG

Location: 39,485 - 69,221 nt. (total: 29,737 nt) Show pHMM detection rules used

azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Azole RiPPs

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: glucosidase hydrolase

C6354_RS12580: Alpha-glucosidase

smcogs: SMCOG1257: Alpha-glucosidase

C6354_RS12595: amidohydrolase

smcogs: SMCOG1244: amidohydrolase

Lyases: dehydratase

C6354_RS12560: Lantibiotic dehydratase domain protein

smcogs: SMCOG1155: Lantibiotic dehydratase domain protein

Translocases: permease

C6354_RS12485: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002311.3	0.51	ribosomal	cutimycin	Cutibacterium acnes KPA171202
BGC0001146.5	0.50	ribosomal	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0000606.5	0.49	ribosomal	lactazole	Streptomyces lactacystinaeus
BGC0001174.4	0.47	ribosomal	corynazolicin	Corynebacterium urealyticum DSM 7111
BGC0000605.5	0.46	ribosomal	GE37468	Streptomyces sp. ATCC 55365
BGC0000607.5	0.45	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0002635.2	0.44	ribosomal	daspyromycin A, daspyromycin B	Actinokineospora diospyrosa
BGC0000565.5	0.44	ribosomal	goadsporin	Streptomyces sp. TP-A0584
BGC0001640.3	0.43	ribosomal	kocurin	Kocuria rosea
BGC0000613.5	0.43	ribosomal	thiomuracin A	Nonomuraea sp. Bp3714-39

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002311.3	0.51	ribosomal	cutimycin	Cutibacterium acnes KPA171202
BGC0001146.5	0.50	ribosomal	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0000606.5	0.49	ribosomal	lactazole	Streptomyces lactacystinaeus
BGC0001174.4	0.47	ribosomal	corynazolicin	Corynebacterium urealyticum DSM 7111
BGC0000605.5	0.46	ribosomal	GE37468	Streptomyces sp. ATCC 55365
BGC0000607.5	0.45	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0002635.2	0.44	ribosomal	daspyromycin A, daspyromycin B	Actinokineospora diospyrosa
BGC0000565.5	0.44	ribosomal	goadsporin	Streptomyces sp. TP-A0584
BGC0001640.3	0.43	ribosomal	kocurin	Kocuria rosea
BGC0000613.5	0.43	ribosomal	thiomuracin A	Nonomuraea sp. Bp3714-39

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.99 out of 30.25

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.62 out of 26.06

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.26 out of 19.26

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.40 out of 27.78

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.18 out of 28.19

Confidence: medium

Additional weak hits (2):

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.23 out of 33.73

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 26.34 out of 33.14

Confidence: weak

(Thi)azol(in)e containing peptide predictions

No core peptides found.

TFBS Finder

Azole RiPPs

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
MogR	Repressor of flagellar motility genes
ZuR variant 1	Zinc-responsive repressor

Core peptide predictions

No core peptides found.

NZ_PVRO01000008.1 - Region 1 - T3PKS,transAT-PKS

Download region GenBank file

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Location: 1 - 28,400 nt. (total: 28,400 nt) Show pHMM detection rules used

Region on contig edge.

transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

C6354_RS14280: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

Transferases: acylase

C6354_RS14205: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

C6354_RS14210: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: hydrolase

C6354_RS14220: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

C6354_RS14300: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

Lyases: hydratase

C6354_RS14185: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

C6354_RS14190: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: synthase

C6354_RS14175: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

C6354_RS14195: hydroxymethylglutaryl-CoA synthase

smcogs: SMCOG1043: hydroxymethylglutaryl-CoA synthase

C6354_RS14275: 8-amino-7-oxononanoate synthase

smcogs: SMCOG1109: 8-amino-7-oxononanoate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002191.2	0.60	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001164.3	0.58	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001257.3	0.57	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0000107.3	0.55	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001244.3	0.55	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001276.3	0.54	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.54	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.54	PKS	asperlactone	Aspergillus ochraceus
BGC0002175.3	0.54	PKS	YWA1	Aspergillus oryzae RIB40
BGC0002154.2	0.53	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002191.2	0.64	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001164.3	0.63	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001257.3	0.62	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0000107.3	0.61	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001244.3	0.61	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001276.3	0.61	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.61	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.61	PKS	asperlactone	Aspergillus ochraceus
BGC0002175.3	0.61	PKS	YWA1	Aspergillus oryzae RIB40
BGC0002154.2	0.60	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.60 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.14 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.62 out of 26.06

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.78 out of 20.97

Confidence: strong

Additional weak hits (8):

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.67 out of 26.06

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 26.07 out of 39.62

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.67 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.08 out of 26.06

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.22 out of 28.14

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.16 out of 32.74

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.96 out of 26.06

Confidence: weak

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.51 out of 26.06

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

TFBS Finder

NRPS/PKS substrate predictions

C6354_RS14205: mal

PKS_AT (4..282): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 87.4
inactive: 28.2
Methoxymalonyl-CoA: 23.4
Methylmalonyl-CoA: 10.9
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

C6354_RS14210: mal

PKS_AT (7..293): mal

ATSignature: (unknown)

No matches above 50%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 38.6
inactive: 27.0
Methoxymalonyl-CoA: 19.2
Benzoyl-CoA: 11.5
Methylmalonyl-CoA: 9.7
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MogR	Repressor of flagellar motility genes
ToxT	Regulator of MSHA biosynthesis