Select genomic region:
Overview
1.1
2.1
3.1
6.1
9.1
10.1
13.1
21.1
21.2
21.3
21.4
23.1
23.2
25.1
25.2
26.1
26.2
28.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_PVRO01000009.1 (Bacillus velezensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | terpene-precursor,NRP-metallophore,NRPS,RiPP-like | 51,524 | 116,845 | High | bacillibactin | NRPS:Type I

NZ_PVRO01000010.1 (Bacillus velezensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 2.1 | terpene | 48,427 | 70,310 |

NZ_PVRO01000011.1 (Bacillus velezensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 3.1 | NRPS | 1 | 22,631 | Low | plipastatin | NRPS:Type I

NZ_PVRO01000014.1 (Bacillus velezensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 6.1 | NRPS | 33,215 | 59,442 | Low | surfactin | NRPS:Type I

NZ_PVRO01000017.1 (Bacillus velezensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 9.1 | NRPS | 1 | 22,575 | Low | fengycin | NRPS:Type I

NZ_PVRO01000001.1 (Bacillus velezensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 10.1 | other | 324,275 | 365,693 | High | bacilysin | other:other

NZ_PVRO01000020.1 (Bacillus velezensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 13.1 | NRPS | 1 | 10,485 |  |

NZ_PVRO01000002.1 (Bacillus velezensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 21.1 | transAT-PKS | 90,832 | 179,062 | High | macrolactin H | PKS
Region 21.2 | lanthipeptide-class-ii | 330,632 | 359,521 |
Region 21.3 | terpene | 524,118 | 544,858 |
Region 21.4 | PKS-like | 627,553 | 668,797 |  |

NZ_PVRO01000003.1 (Bacillus velezensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 23.1 | terpene-precursor | 135,474 | 156,364 |
Region 23.2 | transAT-PKS | 179,680 | 261,187 | High | difficidin | PKS

NZ_PVRO01000005.1 (Bacillus velezensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 25.1 | transAT-PKS-like,NRPS | 1 | 60,230 | Low | bacillaene | NRPS:Type I+PKS:Type I
Region 25.2 | NRPS,transAT-PKS,betalactone | 115,278 | 203,088 | High | fengycin | NRPS:Type I

NZ_PVRO01000006.1 (Bacillus velezensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 26.1 | NRPS | 1 | 28,131 | Low | surfactin | NRPS:Type I
Region 26.2 | azole-containing-RiPP | 39,485 | 69,221 |

NZ_PVRO01000008.1 (Bacillus velezensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 28.1 | transAT-PKS,T3PKS | 1 | 28,400 | High | bacillaene | NRPS:Type I+PKS:Type I

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | terpene-precursor,NRP-metallophore,NRPS,RiPP-like | 51,524 | 116,845 | High | bacillibactin | NRPS:Type I
Region 2.1 | terpene | 48,427 | 70,310 |
Region 3.1 | NRPS | 1 | 22,631 | Low | plipastatin | NRPS:Type I
Region 6.1 | NRPS | 33,215 | 59,442 | Low | surfactin | NRPS:Type I
Region 9.1 | NRPS | 1 | 22,575 | Low | fengycin | NRPS:Type I
Region 10.1 | other | 324,275 | 365,693 | High | bacilysin | other:other
Region 13.1 | NRPS | 1 | 10,485 |  |
Region 21.1 | transAT-PKS | 90,832 | 179,062 | High | macrolactin H | PKS
Region 21.2 | lanthipeptide-class-ii | 330,632 | 359,521 |
Region 21.3 | terpene | 524,118 | 544,858 |
Region 21.4 | PKS-like | 627,553 | 668,797 |  |
Region 23.1 | terpene-precursor | 135,474 | 156,364 |
Region 23.2 | transAT-PKS | 179,680 | 261,187 | High | difficidin | PKS
Region 25.1 | transAT-PKS-like,NRPS | 1 | 60,230 | Low | bacillaene | NRPS:Type I+PKS:Type I
Region 25.2 | NRPS,transAT-PKS,betalactone | 115,278 | 203,088 | High | fengycin | NRPS:Type I
Region 26.1 | NRPS | 1 | 28,131 | Low | surfactin | NRPS:Type I
Region 26.2 | azole-containing-RiPP | 39,485 | 69,221 |
Region 28.1 | transAT-PKS,T3PKS | 1 | 28,400 | High | bacillaene | NRPS:Type I+PKS:Type I

No secondary metabolite regions were found in these records:
  NZ_PVRO01000012.1 (Bacillus velezensis)
  NZ_PVRO01000013.1 (Bacillus velezensis)
  NZ_PVRO01000015.1 (Bacillus velezensis)
  NZ_PVRO01000016.1 (Bacillus velezensis)
  NZ_PVRO01000018.1 (Bacillus velezensis)
  NZ_PVRO01000019.1 (Bacillus velezensis)
  NZ_PVRO01000021.1 (Bacillus velezensis)
  NZ_PVRO01000022.1 (Bacillus velezensis)
  NZ_PVRO01000023.1 (Bacillus velezensis)
  NZ_PVRO01000024.1 (Bacillus velezensis)
  NZ_PVRO01000025.1 (Bacillus velezensis)
  NZ_PVRO01000026.1 (Bacillus velezensis)
  NZ_PVRO01000027.1 (Bacillus velezensis)
  NZ_PVRO01000028.1 (Bacillus velezensis)
  NZ_PVRO01000004.1 (Bacillus velezensis)
  NZ_PVRO01000007.1 (Bacillus velezensis)

Compact view
NZ_PVRO01000009.1 - Region 1 - NRP-metallophore,NRPS,RiPP-like,terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 51,524 - 116,845 nt. (total: 65,322 nt) Show pHMM detection rules used
Region on contig edge.
terpene-precursor: (PT_FPPS_like and not PT_HPP)
NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
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Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase reductase
C6354_RS15365: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

C6354_RS15440: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

C6354_RS15490: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

C6354_RS15500: alkyl hydroperoxide reductase subunit

smcogs
  SMCOG1176: alkyl hydroperoxide reductase subunit

C6354_RS15545: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acetyltransferase
C6354_RS15540: GCN5-related N-acetyltransferase

smcogs
  SMCOG1111: GCN5-related N-acetyltransferase

Hydrolases: esterase hydrolase
C6354_RS15280: thioesterase superfamily protein

smcogs
  SMCOG1144: thioesterase superfamily protein

C6354_RS15330: isochorismatase

smcogs
  SMCOG1027: isochorismatase

C6354_RS15425: isochorismatase

smcogs
  SMCOG1027: isochorismatase

Isomerases: isomerase
C6354_RS15435: isochorismate synthase

smcogs
  SMCOG1018: isochorismate synthase

Ligases: ligase synthetase
C6354_RS15300: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

C6354_RS15420: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

C6354_RS15430: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | NRP-metallophore | NRPS | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | --- | ---
BGC0000616.4 |  |  |  |  | 2.40 | ribosomal | amylocyclicin | Bacillus velezensis FZB42
BGC0001185.5 |  |  |  |  | 1.60 | NRPS | bacillibactin | Bacillus velezensis FZB42
BGC0000309.5 |  |  |  |  | 1.07 | NRPS | bacillibactin | Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5 |  |  |  |  | 1.04 | NRPS | paenibactin | Paenibacillus elgii B69
BGC0002075.3 |  |  |  |  | 0.87 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0000343.5 |  |  |  |  | 0.86 | NRPS | enterobactin | Pseudomonas sp. J465
BGC0001132.4 |  |  |  |  | 0.77 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  |  |  |  | 0.76 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.4 |  |  |  |  | 0.75 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4 |  |  |  |  | 0.75 | NRPS | xenematide | Xenorhabdus nematophila AN6/1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000616.4 |  | 0.95 | ribosomal | amylocyclicin | Bacillus velezensis FZB42
BGC0001185.5 |  | 0.93 | NRPS | bacillibactin | Bacillus velezensis FZB42
BGC0000309.5 |  | 0.81 | NRPS | bacillibactin | Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5 |  | 0.80 | NRPS | paenibactin | Paenibacillus elgii B69
BGC0002075.3 |  | 0.74 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0000343.5 |  | 0.74 | NRPS | enterobactin | Pseudomonas sp. J465
BGC0001132.4 |  | 0.71 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  | 0.70 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.4 |  | 0.70 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4 |  | 0.70 | NRPS | xenematide | Xenorhabdus nematophila AN6/1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP
diterpene precursor |  | GGPP | C20 | acyclic | PP
sesterterpene precursor |  | GFPP | C25 | acyclic | PP
triterpene precursor |  | HPP | C30 | acyclic | PP

Genes with terpene domains:
C6354_RS15300: PT_FPPS_like
Domain 1 (57 - 285): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: unknown

Reactions:
  IPP, DMAPP → FPP
  IPP, DMAPP → GGPP
  IPP, DMAPP → GFPP
  IPP, DMAPP → HPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 29.38 out of 29.38
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.61 out of 29.38
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 27.15 out of 29.38
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.87 out of 27.78
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.49 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.91 out of 29.38
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.52 out of 27.78
Confidence: medium
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.23 out of 21.55
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.11 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.89 out of 27.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.73 out of 28.19
Confidence: strong
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.18 out of 28.19
Confidence: medium
Additional weak hits (17):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.88 out of 26.06
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.44 out of 31.73
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.84 out of 29.25
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.61 out of 32.74
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.12 out of 29.38
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.52 out of 32.74
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.31 out of 29.38
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.58 out of 26.06
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.44 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.15 out of 26.06
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.10 out of 29.25
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.86 out of 26.06
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.11 out of 33.14
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 21.63 out of 30.12
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
Terpene
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 51523 - 116845:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 65052 - 116789:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
C6354_RS15420: Gly - Thr
Search NORINE for peptide: strict or relaxed
AMP-binding (456..855): Gly
nrpys: Gly

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    gly (Gly)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FSMTFDISGLELQALVGGETNLYGPTETTIWSAA
  Nearest Stachelhaus code(s):
    Gly DILQLGLIWK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1513..1929): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LSTHFDFSVWEGNQIFGGEVNMYGITETTVHVSY
  Nearest Stachelhaus code(s):
    Thr DFWNIGMVHK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

C6354_RS15430: diOH-Bz
Search NORINE for peptide: strict or relaxed
AMP-binding (31..435): diOH-Bz
nrpys: diOH-Bz

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Small clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Single AA prediction:
    dhb (diOH-Bz)

Stachelhaus prediction details:
  Stachelhaus sequence:
    SISLYPLSSPGGALQVGGAQQVFGMAEGLVNYTR
  Nearest Stachelhaus code(s):
    diOH-Bz PLPAQGVVNK (100% 8Å match)
    diOH-Bz or Sal PLPAQGVVNK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
GFPP | Geranylfarnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
HPP | Hexaprenyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArcA | Repressor of carbon oxidation
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1 | Ferric Uptake Regulator
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_PVRO01000010.1 - Region 1 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 48,427 - 70,310 nt. (total: 21,884 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
C6354_RS16000: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

Hydrolases: hydrolase
C6354_RS15975: metallo-beta-lactamase family protein

smcogs
  SMCOG1170: metallo-beta-lactamase family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002173.2 |  | 0.46 | saccharide, terpene | fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol | Aspergillus fumigatus A1163
BGC0001535.3 |  | 0.42 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0000313.4 |  | 0.36 | NRPS | beauvericin | Beauveria bassiana
BGC0002255.3 |  | 0.33 | PKS | lijiquinone | Ascomycota sp. F53
BGC0000663.5 |  | 0.30 | terpene | hopene | Streptomyces coelicolor A3(2)
BGC0000686.3 |  | 0.30 | terpene | helvolic acid | Aspergillus fumigatus Af293
BGC0001575.4 |  | 0.29 | NRPS | PZN5, PZN6, PZN7, PZN9, PZN10, PZN11 | Ruminococcus sp. 5_1_39BFAA
BGC0001338.4 |  | 0.28 | PKS | citrinin | Monascus ruber
BGC0000154.4 |  | 0.28 | PKS | stipitatic acid | Talaromyces stipitatus ATCC 10500
BGC0001739.3 |  | 0.28 | other (other) | phosphonoacetic Acid | Streptomyces sp. NRRL F-525

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002173.2 |  | 0.46 | saccharide, terpene | fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol | Aspergillus fumigatus A1163
BGC0001535.3 |  | 0.42 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0000313.4 |  | 0.36 | NRPS | beauvericin | Beauveria bassiana
BGC0002255.3 |  | 0.33 | PKS | lijiquinone | Ascomycota sp. F53
BGC0000663.5 |  | 0.30 | terpene | hopene | Streptomyces coelicolor A3(2)
BGC0000686.3 |  | 0.30 | terpene | helvolic acid | Aspergillus fumigatus Af293
BGC0001575.4 |  | 0.29 | NRPS | PZN5, PZN6, PZN7, PZN9, PZN10, PZN11 | Ruminococcus sp. 5_1_39BFAA
BGC0001338.4 |  | 0.28 | PKS | citrinin | Monascus ruber
BGC0000154.4 |  | 0.28 | PKS | stipitatic acid | Talaromyces stipitatus ATCC 10500
BGC0001739.3 |  | 0.28 | other (other) | phosphonoacetic Acid | Streptomyces sp. NRRL F-525

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene | hopanoid |  | C30 | hopanoid skeleton | unknown
triterpene | polypodane |  | C30 | polypodane skeleton | unknown

Genes with terpene domains:
C6354_RS15995: T2TS
Domain 1 (5 - 625): Type 2 terpene synthase
Subtype: Squalene substrate

Reactions:
  squalene → hopanoid
  squalene → polypodane

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.53 out of 26.06
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 26.30 out of 27.78
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.86 out of 27.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 28.19
Confidence: medium
Additional weak hits (5):
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.63 out of 25.75
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.14 out of 39.62
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.54 out of 26.06
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.10 out of 29.25
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.62 out of 21.55
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.
No acronyms to display
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_PVRO01000011.1 - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 22,631 nt. (total: 22,631 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Ligases: ligase
C6354_RS16145: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

C6354_RS19450: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.71 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001261.3 |  | 0.70 | NRPS | AM-toxin | Alternaria alternata
BGC0001135.5 |  | 0.69 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001166.5 |  | 0.68 | NRPS | HC-toxin | Alternaria jesenskae
BGC0001132.4 |  | 0.68 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0000342.4 |  | 0.68 | NRPS | enniatin | Fusarium equiseti
BGC0001825.4 |  | 0.68 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001833.4 |  | 0.68 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.4 |  | 0.67 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.67 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.71 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001261.3 |  | 0.70 | NRPS | AM-toxin | Alternaria alternata
BGC0001135.5 |  | 0.69 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001166.5 |  | 0.68 | NRPS | HC-toxin | Alternaria jesenskae
BGC0001132.4 |  | 0.68 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0000342.4 |  | 0.68 | NRPS | enniatin | Fusarium equiseti
BGC0001825.4 |  | 0.68 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001833.4 |  | 0.68 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.4 |  | 0.67 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.67 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.39 out of 27.78
Confidence: medium
Additional weak hits (7):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.41 out of 29.38
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.81 out of 39.62
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.13 out of 30.25
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.50 out of 29.38
Confidence: weak
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.37 out of 25.88
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.46 out of 31.73
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.50 out of 26.06
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 22631:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Glu)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
C6354_RS16145: Glu
Search NORINE for peptide: strict or relaxed
AMP-binding (133..538): Glu
nrpys: Glu

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    glu (Glu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FGMSFDASIWQWHFFAGGEIHGYGPTEATVDAAF
  Nearest Stachelhaus code(s):
    Glu DAWHFGGVDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ToxT | Regulator of MSHA biosynthesis

NZ_PVRO01000014.1 - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 33,215 - 59,442 nt. (total: 26,228 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
C6354_RS17630: oxidoreductase

smcogs
  SMCOG1083: oxidoreductase

Transferases: PPTase aminotransferase
C6354_RS17710: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

C6354_RS17715: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Hydrolases: esterase
C6354_RS17720: thioesterase

smcogs
  SMCOG1004: thioesterase

Ligases: ligase
C6354_RS17725: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

C6354_RS17730: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002075.3 |  | 0.75 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0001833.4 |  | 0.70 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0000426.5 |  | 0.69 | NRPS | sevadicin | Paenibacillus larvae
BGC0001128.4 |  | 0.69 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4 |  | 0.68 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001132.4 |  | 0.67 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002071.2 |  | 0.67 | NRPS | virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D | Pseudomonas sp. QS1027
BGC0002286.3 |  | 0.67 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001133.4 |  | 0.66 | NRPS | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0001758.4 |  | 0.66 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002075.3 |  | 0.75 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0001833.4 |  | 0.70 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0000426.5 |  | 0.69 | NRPS | sevadicin | Paenibacillus larvae
BGC0001128.4 |  | 0.69 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4 |  | 0.68 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001132.4 |  | 0.67 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002071.2 |  | 0.67 | NRPS | virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D | Pseudomonas sp. QS1027
BGC0002286.3 |  | 0.67 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001133.4 |  | 0.66 | NRPS | taxlllaid A | Xenorhabdus bovienii SS-2004
BGC0001758.4 |  | 0.66 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.42 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.88 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.41 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.76 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.50 out of 27.78
Confidence: medium
Additional weak hits (6):
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.88 out of 31.73
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.92 out of 26.06
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.35 out of 30.25
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 21.56 out of 31.73
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.99 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.38 out of 26.06
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 33214 - 59442:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Leu)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
C6354_RS17725: Leu
Search NORINE for peptide: strict or relaxed
AMP-binding (469..867): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LHVSFDAFTFDAFALFGGEINCYGPTEGTVFATA
  Nearest Stachelhaus code(s):
    Leu DAFFLGCVFK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis

NZ_PVRO01000017.1 - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 22,575 nt. (total: 22,575 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Ligases: ligase
C6354_RS18250: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

C6354_RS18255: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

C6354_RS18330: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.68 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0000342.4 |  | 0.68 | NRPS | enniatin | Fusarium equiseti
BGC0001132.4 |  | 0.67 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001261.3 |  | 0.67 | NRPS | AM-toxin | Alternaria alternata
BGC0001135.5 |  | 0.67 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001128.4 |  | 0.66 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4 |  | 0.66 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001758.4 |  | 0.65 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0000307.4 |  | 0.65 | NRPS | AbT1 | Aureobasidium pullulans
BGC0001166.5 |  | 0.65 | NRPS | HC-toxin | Alternaria jesenskae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.68 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0000342.4 |  | 0.68 | NRPS | enniatin | Fusarium equiseti
BGC0001132.4 |  | 0.67 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001261.3 |  | 0.67 | NRPS | AM-toxin | Alternaria alternata
BGC0001135.5 |  | 0.67 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001128.4 |  | 0.66 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001833.4 |  | 0.66 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001758.4 |  | 0.65 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0000307.4 |  | 0.65 | NRPS | AbT1 | Aureobasidium pullulans
BGC0001166.5 |  | 0.65 | NRPS | HC-toxin | Alternaria jesenskae

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.17 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.51 out of 27.78
Confidence: medium
Additional weak hits (4):
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.08 out of 28.14
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.23 out of 33.73
Confidence: weak
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.29 out of 25.75
Confidence: weak
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 20.85 out of 27.04
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 22575:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (D-X) + (Pro)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
C6354_RS18250: Pro - Gln
Search NORINE for peptide: strict or relaxed
AMP-binding (469..866): Pro
nrpys: Pro

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
  Small clusters prediction:
    pro (Pro)
  Single AA prediction:
    pro (Pro)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LDQAFDVCYQESFFITAGEHNHYGPSETHVVSTY
  Nearest Stachelhaus code(s):
    Pro DVQFIAHVVK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1500..1901): Gln
nrpys: Gln

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    glu (Glu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FSLTFDASIWEWHFFAGGETNSYGPTEATVEAAY
  Nearest Stachelhaus code(s):
    Gln DAWHFGSVEK (100% 8Å match)
    Glu DAWHFGSVEK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

C6354_RS18255: X
AMP-binding (1..211): X
nrpys: Ala, Val

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    val (Val)

Stachelhaus prediction details:
  Stachelhaus sequence:
    ----FDVTTFEGWLIIGGEWNGYGPTENTTFSTC
  Nearest Stachelhaus code(s):
    Ala or Val DVFWIGGTFK (85% 8Å match)
    Val DVFWIGGTFK (82% 8Å match)
  Stachelhaus code match:
    100% (strong)

C6354_RS18330: X
AMP-binding (215..385): X
No predictions made
Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria

NZ_PVRO01000001.1 - Region 1 - other
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 324,275 - 365,693 nt. (total: 41,419 nt) Show pHMM detection rules used
other: (Neocarzinostat or bcpB or frbD or mitE or prnB or CaiA or bacilysin or orf2_PTase)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
C6354_RS01710: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

C6354_RS01745: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

C6354_RS01765: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: aminotransferase transferase
C6354_RS01660: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs
  SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

C6354_RS01760: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Lyases: dehydratase lyase
C6354_RS01665: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

C6354_RS01670: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

C6354_RS01750: argininosuccinate lyase/adenylosuccinate lyase

smcogs
  SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Translocases: permease
C6354_RS01720: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

C6354_RS01855: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | other | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001184.4 |  | 0.97 | other (other) | bacilysin | Bacillus velezensis FZB42
BGC0000888.5 |  | 0.97 | other (other) | bacilysin | Bacillus sp. CS93
BGC0000794.5 |  | 0.53 | saccharide | S-layer glycan | Geobacillus stearothermophilus
BGC0000898.5 |  | 0.53 | saccharide | desosamine, pikromycin, neomethymycin, narbomycin | Streptomyces venezuelae
BGC0000790.3 |  | 0.52 | saccharide | O-antigen | Escherichia coli
BGC0000773.3 |  | 0.52 | saccharide | lipopolysaccharide | Escherichia coli
BGC0000791.3 |  | 0.52 | saccharide | O-antigen | Cronobacter sakazakii
BGC0001928.2 |  | 0.51 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0000813.3 |  | 0.51 | other (other) | K-252a | Nonomuraea longicatena
BGC0000899.4 |  | 0.50 | saccharide | desosamine | Streptomyces narbonensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001184.4 |  | 0.97 | other (other) | bacilysin | Bacillus velezensis FZB42
BGC0000888.5 |  | 0.97 | other (other) | bacilysin | Bacillus sp. CS93
BGC0000794.5 |  | 0.53 | saccharide | S-layer glycan | Geobacillus stearothermophilus
BGC0000898.5 |  | 0.53 | saccharide | desosamine, pikromycin, neomethymycin, narbomycin | Streptomyces venezuelae
BGC0000790.3 |  | 0.52 | saccharide | O-antigen | Escherichia coli
BGC0000773.3 |  | 0.52 | saccharide | lipopolysaccharide | Escherichia coli
BGC0000791.3 |  | 0.52 | saccharide | O-antigen | Cronobacter sakazakii
BGC0001928.2 |  | 0.51 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0000813.3 |  | 0.51 | other (other) | K-252a | Nonomuraea longicatena
BGC0000899.4 |  | 0.50 | saccharide | desosamine | Streptomyces narbonensis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Location:
Identifier
Identity
Coverage
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.22 out of 18.46
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.26 out of 29.38
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.49 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.85 out of 27.78
Confidence: medium
Additional weak hits (6):
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 21.66 out of 30.97
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 26.15 out of 36.54
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.29 out of 36.54
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.68 out of 33.14
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.37 out of 20.01
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.89 out of 32.93
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1 | Ferric Uptake Regulator
RpoN | Regulator of nitrogen assimilation and virulence
ToxT | Regulator of MSHA biosynthesis

NZ_PVRO01000020.1 - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 10,485 nt. (total: 10,485 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Ligases: ligase
C6354_RS18520: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.71 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001261.3 |  | 0.71 | NRPS | AM-toxin | Alternaria alternata
BGC0000396.5 |  | 0.70 | NRPS | nodularin | Nostoc sp. 73.1
BGC0001833.4 |  | 0.70 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001050.5 |  | 0.69 | NRPS, PKS | thalassospiramide A | Tistrella bauzanensis
BGC0000342.4 |  | 0.68 | NRPS | enniatin | Fusarium equiseti
BGC0001825.4 |  | 0.68 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001135.5 |  | 0.68 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0002286.3 |  | 0.68 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001166.5 |  | 0.67 | NRPS | HC-toxin | Alternaria jesenskae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.71 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001261.3 |  | 0.71 | NRPS | AM-toxin | Alternaria alternata
BGC0000396.5 |  | 0.70 | NRPS | nodularin | Nostoc sp. 73.1
BGC0001833.4 |  | 0.70 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001050.5 |  | 0.69 | NRPS, PKS | thalassospiramide A | Tistrella bauzanensis
BGC0000342.4 |  | 0.68 | NRPS | enniatin | Fusarium equiseti
BGC0001825.4 |  | 0.68 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001135.5 |  | 0.68 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0002286.3 |  | 0.68 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001166.5 |  | 0.67 | NRPS | HC-toxin | Alternaria jesenskae

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 10485:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Val - Asp)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
C6354_RS19480: Val - Asp
Search NORINE for peptide: strict or relaxed
AMP-binding (470..864): Val
nrpys: Val

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    val (Val)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LHSGFDAGTFEGWLIIGGDWNGYGPTENTTFSTS
  Nearest Stachelhaus code(s):
    Val DAFWIGGTFK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1502..1904): Asp
nrpys: Asp

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asp (Asp)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWFSFDLGYTAPKLVLGGEINHYGPTETTIGAIA
  Nearest Stachelhaus code(s):
    Asp DLTKVGHIGK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
NZ_PVRO01000002.1 - Region 1 - transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 90,832 - 179,062 nt. (total: 88,231 nt) Show pHMM detection rules used
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase
C6354_RS04965: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

C6354_RS04995: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

C6354_RS05005: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

C6354_RS05010: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

C6354_RS05020: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acylase kinase
C6354_RS05025: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

C6354_RS05135: PfkB domain protein

smcogs
  SMCOG1276: PfkB domain protein

Hydrolases: deacetylase deformylase hydrolase phosphatase
C6354_RS04920: inositol monophosphatase

smcogs
  SMCOG1207: inositol monophosphatase

C6354_RS04955: polysaccharide deacetylase

smcogs
  SMCOG1235: polysaccharide deacetylase

C6354_RS04985: beta-lactamase

smcogs
  SMCOG1053: beta-lactamase

C6354_RS04990: alpha/beta hydrolase fold protein

smcogs
  SMCOG1036: alpha/beta hydrolase fold protein

C6354_RS05045: peptide deformylase

smcogs
  SMCOG1275: peptide deformylase

C6354_RS05050: hydrolase

smcogs
  SMCOG1179: hydrolase

Ligases: synthase
C6354_RS04975: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

C6354_RS05015: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | transAT-PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000181.5 |  | 0.89 | PKS | macrolactin H | Bacillus velezensis FZB42
BGC0001383.3 |  | 0.89 | PKS | macrolactin H, macrolactin B, macrolactin 1c, macrolactin E | Jeotgalibacillus marinus
BGC0001534.3 |  | 0.70 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0001276.3 |  | 0.64 | PKS | 6-methylsalicyclic acid | Aspergillus terreus
BGC0001244.3 |  | 0.64 | PKS | (-)-Mellein | Parastagonospora nodorum
BGC0001275.3 |  | 0.64 | PKS | 6-methylsalicyclic acid | Glarea lozoyensis
BGC0001273.3 |  | 0.63 | PKS | asperlactone | Aspergillus ochraceus
BGC0001160.5 |  | 0.63 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0001164.3 |  | 0.63 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0001284.4 |  | 0.63 | PKS | alternariol | Parastagonospora nodorum SN15

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000181.5 |  | 0.89 | PKS | macrolactin H | Bacillus velezensis FZB42
BGC0001383.3 |  | 0.89 | PKS | macrolactin H, macrolactin B, macrolactin 1c, macrolactin E | Jeotgalibacillus marinus
BGC0001534.3 |  | 0.70 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0001276.3 |  | 0.64 | PKS | 6-methylsalicyclic acid | Aspergillus terreus
BGC0001244.3 |  | 0.64 | PKS | (-)-Mellein | Parastagonospora nodorum
BGC0001275.3 |  | 0.64 | PKS | 6-methylsalicyclic acid | Glarea lozoyensis
BGC0001273.3 |  | 0.63 | PKS | asperlactone | Aspergillus ochraceus
BGC0001160.5 |  | 0.63 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0001164.3 |  | 0.63 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0001284.4 |  | 0.63 | PKS | alternariol | Parastagonospora nodorum SN15

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.63 out of 27.78
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.94 out of 21.55
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.16 out of 26.06
Confidence: medium
Additional weak hits (6):
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.35 out of 26.33
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.27 out of 30.22
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.56 out of 29.38
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.30 out of 26.06
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.99 out of 33.14
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.94 out of 29.65
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 90831 - 179062:
Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:
  (ohmal - ccmal - ccmal) + (ccmal) + (ccmal - mal) + (ccmal - mal) + (ohmal) + (ohmal - mal)
Non-colinear ordering:
  C6354_RS05020 + C6354_RS05015 + C6354_RS05010 + C6354_RS05005 + C6354_RS05000 + C6354_RS04995 + C6354_RS04990

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
C6354_RS05025: mal
PKS_AT (4..282): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 75.0%
  inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 92.6
  inactive: 32.0
  Methoxymalonyl-CoA: 28.0
  Methylmalonyl-CoA: 20.8
  Propionyl-CoA: 17.4
  fatty_acid: 13.9
  trans-1,2-CPDA: 0.0
  Isobutyryl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArcA | Repressor of carbon oxidation
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis

NZ_PVRO01000002.1 - Region 2 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 330,632 - 359,521 nt. (total: 28,890 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: cyclase
C6354_RS06015: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

C6354_RS06025: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000554.4 |  | 0.56 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000516.4 |  | 0.53 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000626.3 |  | 0.52 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000528.5 |  | 0.51 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001555.4 |  | 0.51 | ribosomal | colicin V | Escherichia coli chi7122
BGC0001210.5 |  | 0.51 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000590.5 |  | 0.50 | ribosomal | microcin N | Escherichia coli
BGC0001311.5 |  | 0.50 | ribosomal | flavecins | Ruminococcus flavefaciens FD-1
BGC0000539.5 |  | 0.50 | ribosomal | nukacin ISK-1 | Staphylococcus warneri
BGC0000527.5 |  | 0.49 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000554.4 |  | 0.56 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000516.4 |  | 0.53 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000626.3 |  | 0.52 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000528.5 |  | 0.51 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001555.4 |  | 0.51 | ribosomal | colicin V | Escherichia coli chi7122
BGC0001210.5 |  | 0.51 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000590.5 |  | 0.50 | ribosomal | microcin N | Escherichia coli
BGC0001311.5 |  | 0.50 | ribosomal | flavecins | Ruminococcus flavefaciens FD-1
BGC0000539.5 |  | 0.50 | ribosomal | nukacin ISK-1 | Staphylococcus warneri
BGC0000527.5 |  | 0.49 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for C6354_RS06015

C6354_RS18850
Leader:
MCKLCGPKKVIVTETGFGA
Core:
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K A R L D A R V
Core with dehydrations:
V F H P Cys P N Cys K Dhb G Dhb D L Dhb P V I K R L E R M V Q D A K A R L D A R V

#### antiSMASH-DB 4.0 matches for C6354_RS18850

100.0%
NC_023073.1 and 25 others:
NZ_CP010556.1 Lanthipeptides: SB45_RS19805_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19795_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20400_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22075_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS21000_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21480_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19740_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS19585_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20470_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21110_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20035_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16480_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06705_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18975_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06485_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16830_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06200_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12895_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06150_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06335_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11720_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS03045_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19745_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS19365_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18850_lanthipeptide
Lanthipeptides: U722_RS20005_lanthipeptide
1
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K A R L D A R V
36
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K A R L D A R V
1
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K A R L D A R V
36
97.2%
NZ_CP025341.1:
Lanthipeptides: CXR48_RS19565_lanthipeptide
1
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K A R L D A R V
36
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K A R L D R V
1
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K A R L D L R V
36
89.7%
NZ_CP023075.1 and 8 others:
NZ_CP035393.1 Lanthipeptides: ES966_RS21105_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20970_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19665_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17705_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03370_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01895_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00520_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122700_lanthipeptide
Lanthipeptides: CK238_RS20695_lanthipeptide
1
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K A R L D A R V
36
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K R L D A R V
1
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K V R L D A R V
36
with 2 more sequence matches
22.2%
NC_015600.1 and 17 others:
NZ_AP020310.1 Lanthipeptides: SAGCMC97051_RS07300_lanthipeptide NZ_ATVP01000001.1 Lanthipeptides: G574_RS11150_lanthipeptide NZ_BCFB01000042.1 Lanthipeptides: GOZ36_RS07980_lanthipeptide NZ_CP024974.1 Lanthipeptides: CVO91_RS06555_lanthipeptide NZ_CP068708.1 Lanthipeptides: JM964_RS04040_lanthipeptide NZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptide NZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptide NZ_FIKS01000005.1 Lanthipeptides: A0525_RS10015_lanthipeptide NZ_GL636070.1 Lanthipeptides: HMPREF9171_RS106200_lanthipeptide NZ_JADPLU010000018.1 Lanthipeptides: I4V82_RS09545_lanthipeptide NZ_JAIMDQ010000006.1 Lanthipeptides: K6V44_RS04045_lanthipeptide NZ_JAKVIE010000017.1 Lanthipeptides: MK857_RS08340_lanthipeptide NZ_JAMDIB010000004.1 Lanthipeptides: M5P35_RS04030_lanthipeptide NZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptide NZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptide NZ_LR594050.1 Lanthipeptides: FGL20_RS03485_lanthipeptide NZ_SSXN01000004.1 Lanthipeptides: FAJ36_RS04715_lanthipeptide
Lanthipeptides: SGPB_RS10680_lanthipeptide
6
P N C K T G T D L T P V I K
19
P C K T G +T I K
9
P G C K T G I L M T C A I K
22
22.2%
NZ_CP059471.1 and 3 others:
NZ_FNZW01000001.1 Lanthipeptides: BMZ61_RS02110_lanthipeptide NZ_FOYC01000001.1 Lanthipeptides: BMZ88_RS03370_lanthipeptide NZ_KE384124.1 Lanthipeptides: G597_RS0106700_lanthipeptide
Lanthipeptides: H1R75_RS06635_lanthipeptide
6
P N C K T G T D L T P V I K
19
P C K T G +T I K
9
P G C K T G A L M T C P I K
22

#### MIBiG 4.0 matches for C6354_RS18850

13.9%
BGC0000535.4 (ADJ56352.1):
Lanthipeptide: nisin A
6
P N C K T G
11
P C K T G
9
P G C K T G
14
C6354_RS18855
Leader:
MKKDFQALTPMTEEELKNLAGG
Core:
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
Core with dehydrations:
Dha D A Dhb P M Dhb V Dhb P Dhb Dhb I Dhb I P I Dha L A G Cys P Dhb Dhb K Cys A Dha I V Dha P Cys N D

#### antiSMASH-DB 4.0 matches for C6354_RS18855

100.0%
NC_023073.1 and 71 others:
NC_023073.1 Lanthipeptides: U722_RS19995_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide
Lanthipeptides: U722_RS19995_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
97.2%
NC_023073.1 and 71 others:
NC_023073.1 Lanthipeptides: U722_RS19990_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide
Lanthipeptides: U722_RS19990_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S+A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
94.4%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10245_lanthipeptide
Lanthipeptides: J7E20_RS10245_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S D A P M T+T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S D A A P M T I T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
with 60 more sequence matches
Only the first 10 are displayed here.
66.7%
NZ_JAMDLZ010000027.1:
Lanthipeptides: M5W82_RS15520_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T+T I P I S L A G C P T T K C A S I V S P C
8
T P L T V T I P I S L A G C P T T K C A S I V S P C K G
35
63.9%
NZ_WIXN01000006.1 and 1 other:
NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide
Lanthipeptides: GHD25_RS06900_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C
34
D A T P T P T T I I P+S L A C P T T C S S P C
1
E D A T P D T-H P T T I-I P V S L A V C P T T T C R S F S S P C
32
63.2%
NZ_AUCI01000015.1 and 1 other:
NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide
Lanthipeptides: G475_RS0114655_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S D P + T T+T I P I S G C P T T K C A S+V P C N D
3
S D Q Q P A S H P T T T V T I P I S A W G C P T T K C A S V V E P C N D
38
63.2%
NZ_FOXD01000022.1 and 1 other:
NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide
Lanthipeptides: BM124_RS15255_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S D P + T T+T I P I S G C P T T K C A S+V P C N D
3
S D Q Q P A S H P T T T V T I P I S A W G C P T T K C A S V V K P C N D
38
61.1%
NZ_CP063142.1 and 5 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide
Lanthipeptides: HPB58_RS21455_lanthipeptide
12
T I T I P I S L A G C P T T K C A S I V S P C N D
36
T+T I P I S L A C P T T+C A S I V S P C N D
8
T V T I P I S L A A C P T T Q C A S I V S P C N D
32
61.1%
NZ_LT745762.1 and 1 other:
NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide
Lanthipeptides: B2C77_RS21505_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T I I P+S L A C P T T K C A S+V P C N D
7
T P A T I-I P V S L A I C P T T K C A S V V K P C N D
33
58.3%
NZ_BOSN01000007.1 and 3 others:
NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide
Lanthipeptides: KJS43_RS18000_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T I I P+S L A C P T T K C A S+V P C N
7
T P A T I-I P V S L A I C P T T K C A S V V K P C N G
33
58.3%
NZ_BQME02000001.1 and 3 others:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide
Lanthipeptides: MFF31_RS04090_lanthipeptide
12
T I T I P I S L A G C P T T K C A S I V S P C N
35
T I I P I S L A C P T T+C A S I V S P C N
6
T I I I P I S L A A C P T T R C A S I V S P C N
29
55.6%
NZ_BQME02000001.1 and 1 other:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04085_lanthipeptide
Lanthipeptides: MFF31_RS04085_lanthipeptide
12
T I T I P I S L A G C P T T K C A S I V S P C N
35
T I I P I S L A C P T T+C A S I V S C N
6
T I I I P I S L A A C P T T R C A S I V S S C N
29
55.6%
NZ_KQ040792.1 and 1 other:
NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide
Lanthipeptides: WH45_RS23705_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T I I P+S L A C P T T+C A S I V C N
8
T P A T I-I P V S L A I C P T T R C A S I V E S C N G
34

#### MIBiG 4.0 matches for C6354_RS18855

24.3%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
13
I T I P I S L A G C P T T K C A S
29
+ + +S A C P T T K C S
19
V A V G V S A A F C P T T K C T S
35
19.4%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
22
C P T T K C A S
29
C P T T K C S
17
C P T T K C T S
24
C6354_RS18860
Leader:
MKKEFLALELMTEEELKELAGG
Core:
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
Core with dehydrations:
Dha E A Dhb P M Dhb V Dhb P Dhb Dhb I Dhb I P I Dha L A G Cys P Dhb Dhb K Cys A Dha I V Dha P Cys N D

#### antiSMASH-DB 4.0 matches for C6354_RS18860

100.0%
NC_023073.1 and 71 others:
NC_023073.1 Lanthipeptides: U722_RS19990_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide
Lanthipeptides: U722_RS19990_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
97.2%
NC_023073.1 and 71 others:
NC_023073.1 Lanthipeptides: U722_RS19995_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide
Lanthipeptides: U722_RS19995_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S+A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
97.2%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10240_lanthipeptide
Lanthipeptides: J7E20_RS10240_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S E A T P M T+T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S E A T P M T I T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
with 60 more sequence matches
Only the first 10 are displayed here.
91.7%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10245_lanthipeptide
Lanthipeptides: J7E20_RS10245_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S+A P M T+T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S D A A P M T I T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
66.7%
NZ_JAMDLZ010000027.1:
Lanthipeptides: M5W82_RS15520_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T+T I P I S L A G C P T T K C A S I V S P C
8
T P L T V T I P I S L A G C P T T K C A S I V S P C K G
35
63.9%
NZ_KQ040792.1 and 1 other:
NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide
Lanthipeptides: WH45_RS23705_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N
35
+E+T P T P T I I P+S L A C P T T+C A S I V C N
1
A E S T P-N G T P A T I-I P V S L A I C P T T R C A S I V E S C N
33
61.1%
NZ_CP063142.1 and 5 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide
Lanthipeptides: HPB58_RS21455_lanthipeptide
12
T I T I P I S L A G C P T T K C A S I V S P C N D
36
T+T I P I S L A C P T T+C A S I V S P C N D
8
T V T I P I S L A A C P T T Q C A S I V S P C N D
32
61.1%
NZ_LT745762.1 and 1 other:
NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide
Lanthipeptides: B2C77_RS21505_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T I I P+S L A C P T T K C A S+V P C N D
7
T P A T I-I P V S L A I C P T T K C A S V V K P C N D
33
61.1%
NZ_WIXN01000006.1 and 1 other:
NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide
Lanthipeptides: GHD25_RS06900_lanthipeptide
2
E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C
34
+A T P T P T T I I P+S L A C P T T C S S P C
2
D A T P D T-H P T T I-I P V S L A V C P T T T C R S F S S P C
32
60.5%
NZ_AUCI01000015.1 and 1 other:
NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide
Lanthipeptides: G475_RS0114655_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S+ P + T T+T I P I S G C P T T K C A S+V P C N D
3
S D Q Q P A S H P T T T V T I P I S A W G C P T T K C A S V V E P C N D
38
60.5%
NZ_FOXD01000022.1 and 1 other:
NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide
Lanthipeptides: BM124_RS15255_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S+ P + T T+T I P I S G C P T T K C A S+V P C N D
3
S D Q Q P A S H P T T T V T I P I S A W G C P T T K C A S V V K P C N D
38
58.3%
NZ_BOSN01000007.1 and 3 others:
NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide
Lanthipeptides: KJS43_RS18000_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T I I P+S L A C P T T K C A S+V P C N
7
T P A T I-I P V S L A I C P T T K C A S V V K P C N G
33
58.3%
NZ_BQME02000001.1 and 3 others:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide
Lanthipeptides: MFF31_RS04090_lanthipeptide
12
T I T I P I S L A G C P T T K C A S I V S P C N
35
T I I P I S L A C P T T+C A S I V S P C N
6
T I I I P I S L A A C P T T R C A S I V S P C N
29

#### MIBiG 4.0 matches for C6354_RS18860

24.3%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
13
I T I P I S L A G C P T T K C A S
29
+ + +S A C P T T K C S
19
V A V G V S A A F C P T T K C T S
35
19.4%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
22
C P T T K C A S
29
C P T T K C S
17
C P T T K C T S
24
C6354_RS06030
Leader:
MNEKMYRFAGDLREELEEISLS
Core:
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
Core with dehydrations:
E F Dha G G G G A E Q R G I Dha Q G N D G K L Cys Dhb L Dhb W E Cys G L Cys P Dhb H Dhb Cys W Cys

#### antiSMASH-DB 4.0 matches for C6354_RS06030

100.0%
NC_023073.1 and 65 others:
NC_023073.1 Lanthipeptides: U722_RS06170_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptide
Lanthipeptides: U722_RS06170_lanthipeptide
1
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
1
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
97.4%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10220_lanthipeptide
Lanthipeptides: J7E20_RS10220_lanthipeptide
1
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C+C
1
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C F C
38
86.8%
NZ_CP016371.1 and 7 others:
NZ_CP016371.1 Lanthipeptides: A5891_RS06120_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptide
Lanthipeptides: A5891_RS06120_lanthipeptide
6
G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
1
G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
33
with 92 more sequence matches
Only the first 10 are displayed here.
71.1%
NZ_BQME02000001.1 and 1 other:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04105_lanthipeptide
Lanthipeptides: MFF31_RS04105_lanthipeptide
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C-W C
38
A E Q R G I S Q G N D G K C T L T W E C +C P T T C W C
1
A E Q R G I S Q G N D G K Y C T L T W E C S V C P T L T C F W C
32
68.4%
NZ_CP063142.1 and 10 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21475_lanthipeptide NZ_FOXX01000007.1 Lanthipeptides: BM012_RS26100_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptide NZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptide NZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptide
Lanthipeptides: HPB58_RS21475_lanthipeptide
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E Q R G I S Q G N D G C T+T W E C +C P T H T C W C
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
68.4%
NZ_FOXD01000022.1 and 1 other:
NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15270_lanthipeptide
Lanthipeptides: BM124_RS15270_lanthipeptide
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E R G I S Q G N D G C T+T W E C G+C P T H T C W C
3
A E P R G I S Q G N D G D Y C T I T W E C G M C P T H T C W C
33
68.4%
NZ_KQ040792.1 and 1 other:
NZ_KQ040792.1 Lanthipeptides: WH45_RS23330_lanthipeptide
Lanthipeptides: WH45_RS23330_lanthipeptide
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E +G+S Q G N D G K+C T L T W E C G L C P T H T C+C
1
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F C
31
65.8%
NZ_BOSN01000007.1 and 3 others:
NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18005_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptide
Lanthipeptides: KJS43_RS18005_lanthipeptide
7
G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E G I S Q G N D G K C T+T W E C +C P T H T C W C
1
A A E P M G I S Q G N D G K Y C T I T W E C S I C P T H T C W C
32
65.8%
NZ_LT745762.1 and 1 other:
NZ_LT745762.1 Lanthipeptides: B2C77_RS00795_lanthipeptide
Lanthipeptides: B2C77_RS00795_lanthipeptide
7
G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E G I S Q G N D G K C T+T W E C +C P T H T C W C
1
A A E P M G I S Q G N D G K W C T V T W E C S I C P T H T C W C
32
63.2%
NZ_AUCI01000015.1 and 1 other:
NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114640_lanthipeptide
Lanthipeptides: G475_RS0114640_lanthipeptide
6
G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
E R G+S Q G N D G C T+T W E C G+C P T H T C W C
1
A D V E T R G L S Q G N D G D Y C T I T W E C G M C P T H T C W C
33
63.2%
NZ_CP101913.1 and 1 other:
NZ_CP101913.1 Lanthipeptides: NP440_RS09135_lanthipeptide
Lanthipeptides: NP440_RS09135_lanthipeptide
7
G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E G I S+ N D G K C T L T W E C +C P T H T C W C
1
A A E P M G I S E D N D G K Y C T L T W E C S I C P T H T C W C
32
63.2%
NZ_KV917378.1 and 1 other:
NZ_KV917378.1 Lanthipeptides: BK581_RS07320_lanthipeptide
Lanthipeptides: BK581_RS07320_lanthipeptide
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A+ +G I S Q G N D G K C T+T W E C +C P T H T C W C
1
A D V Q G I S Q G N D G K Y C T I T W E C S I C P T H T C W C
31
55.3%
NZ_CP040417.1 and 7 others:
NZ_CP040417.1 Lanthipeptides: FE328_RS09040_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide
Lanthipeptides: FE328_RS09040_lanthipeptide
5
G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W
37
G G R +S+G N G K+C T L T W E C G+C P+H T C+
1
G V G K W I R K L S K G N T G K V C T L T W E C G I C P S H T C F
33

#### MIBiG 4.0 matches for C6354_RS06030

23.7%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
16
G N D G K L C T L T W E C
28
G N G C T L T E C
11
G N K G A Y C T L T V E C
23
23.7%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
16
G N D G K L C T L T W E C
28
G N+G C T L T E C
13
G N N G G W C T L T K E C
25
15.8%
BGC0000580.3 (EGD17355.1):
Lasso peptide: xanthomonin II or xanthomonin I
6
G G A E Q R G I S Q
15
G G G I S Q
10
G G I T T L G I S Q
19
with 1 more sequence matches
12.8%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
22
C T L T W E C
28
C T L+ E C
28
C T L S K E C
34
allorf_330876_330977
Leader:
MSYVCHLEVNRRSQKAARLEAA
Core:
F Y Y R Q S C R R W R
Core with dehydrations:
F Y Y R Q Dha Cys R R W R

#### antiSMASH-DB 4.0 matches for allorf_330876_330977

100.0%
NC_023073.1 and 25 others:
NZ_CP010556.1 Lanthipeptides: allorf_1184096_1184197_lanthipeptide NZ_CP016371.1 Lanthipeptides: allorf_1217185_1217286_lanthipeptide NZ_CP016395.1 Lanthipeptides: allorf_1280116_1280217_lanthipeptide NZ_CP018295.1 Lanthipeptides: allorf_1237649_1237750_lanthipeptide NZ_CP023133.1 Lanthipeptides: allorf_0814210_0814311_lanthipeptide NZ_CP025341.1 Lanthipeptides: allorf_1220484_1220585_lanthipeptide NZ_CP027429.1 Lanthipeptides: allorf_2632526_2632603_lanthipeptide NZ_CP028440.1 Lanthipeptides: allorf_1156108_1156209_lanthipeptide NZ_CP031694.1 Lanthipeptides: allorf_3744466_3744567_lanthipeptide NZ_CP033967.1 Lanthipeptides: allorf_3531374_3531475_lanthipeptide NZ_CP044133.1 Lanthipeptides: allorf_1298847_1298948_lanthipeptide NZ_CP059405.1 Lanthipeptides: allorf_3182941_3183042_lanthipeptide NZ_CP059495.1 Lanthipeptides: allorf_1285088_1285189_lanthipeptide NZ_CP064091.1 Lanthipeptides: allorf_3842801_3842902_lanthipeptide NZ_CP065790.1 Lanthipeptides: allorf_1242067_1242168_lanthipeptide NZ_CP072310.1 Lanthipeptides: allorf_3353378_3353479_lanthipeptide NZ_CP074685.1 Lanthipeptides: allorf_1233992_1234093_lanthipeptide NZ_CP075054.1 Lanthipeptides: allorf_2689692_2689793_lanthipeptide NZ_CP088300.1 Lanthipeptides: allorf_1187843_1187944_lanthipeptide NZ_CP090905.1 Lanthipeptides: allorf_1214408_1214509_lanthipeptide NZ_CP094618.1 Lanthipeptides: allorf_1148352_1148453_lanthipeptide NZ_CP119675.1 Lanthipeptides: allorf_2196063_2196164_lanthipeptide NZ_KN050798.1 Lanthipeptides: allorf_0358200_0358301_lanthipeptide NZ_LN999829.1 Lanthipeptides: allorf_1199095_1199196_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: allorf_330876_330977_lanthipeptide
Lanthipeptides: allorf_1251961_1252062_lanthipeptide
1
F Y Y R Q S C R R W R
11
F Y Y R Q S C R R W R
1
F Y Y R Q S C R R W R
11
5.9%
NZ_FMXV01000022.1:
Lanthipeptides: allorf_002190_002423_lanthipeptide
3
Y R Q S C R R W R
11
+ ++C R W R
57
W E R A C S R W R
65
allorf_335356_335517
Leader:
MNRGARFYIHWSYAAQEVLGG
Core:
Q H G E N S V M M Q K P F L R F K M M T F C R L R F K P A E N R
Core with dehydrations:
Q H G E N Dha V M M Q K P F L R F K M M Dhb F Cys R L R F K P A E N R

#### antiSMASH-DB 4.0 matches for allorf_335356_335517

100.0%
NZ_CP017775.1 and 9 others:
NZ_CP023075.1 Lanthipeptides: allorf_1289301_1289462_lanthipeptide NZ_CP035393.1 Lanthipeptides: allorf_1371482_1371643_lanthipeptide NZ_CP044444.1 Lanthipeptides: allorf_2629421_2629582_lanthipeptide NZ_CP059405.1 Lanthipeptides: allorf_3178400_3178561_lanthipeptide NZ_CP083716.1 Lanthipeptides: allorf_113041_113202_lanthipeptide NZ_CP092110.1 Lanthipeptides: allorf_0702092_0702253_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS03015_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122870_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: allorf_335356_335517_lanthipeptide
Lanthipeptides: allorf_1372345_1372506_lanthipeptide
1
Q H G E N S V M M Q K P F L R F K M M T F C R L R F K P A E N R
32
Q H G E N S V M M Q K P F L R F K M M T F C R L R F K P A E N R
1
Q H G E N S V M M Q K P F L R F K M M T F C R L R F K P A E N R
32
40.6%
NC_023073.1 and 9 others:
NZ_CP016395.1 Lanthipeptides: BBJ33_RS20395_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21475_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19560_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS19590_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20475_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06455_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06170_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06305_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS19360_lanthipeptide
Lanthipeptides: U722_RS20000_lanthipeptide
1
Q H G E N S V M M Q K P F L R
15
Q H G+ S V M M Q K P F L R
1
Q H G D Y S V M M Q K P F L R
15
21.9%
NZ_JXCA02000027.1:
Lanthipeptides: allorf_403131_403280_lanthipeptide
10
Q K P F L R F K M M T F C
22
Q P F L R + F C
12
Q P P F L R E G L C K F C
24
with 1 more sequence matches
15.2%
NZ_KB235948.1:
Lanthipeptides: OSC10802_RS0121020_lanthipeptide
15
R F K M M T F C R L R F K P A E N R
32
R F C+ F P A+ R
11
R F M K A M L C K D S F S P A D R R
28
allorf_337625_337702
Leader:
MRIHSIFIRMQGLYA
Core:
Q V I C P T N A T Y
Core with dehydrations:
Q V I Cys P Dhb N A Dhb Y

#### antiSMASH-DB 4.0 matches for allorf_337625_337702

100.0%
NZ_CP016371.1 and 22 others:
NZ_CP017775.1 Lanthipeptides: allorf_1370160_1370237_lanthipeptide NZ_CP018295.1 Lanthipeptides: allorf_1230930_1231007_lanthipeptide NZ_CP023075.1 Lanthipeptides: allorf_1287116_1287193_lanthipeptide NZ_CP027429.1 Lanthipeptides: allorf_2639262_2639339_lanthipeptide NZ_CP027429.1 Lanthipeptides: allorf_2639262_2639339_lanthipeptide NZ_CP033967.1 Lanthipeptides: allorf_3538116_3538193_lanthipeptide NZ_CP033967.1 Lanthipeptides: allorf_3538116_3538193_lanthipeptide NZ_CP044133.1 Lanthipeptides: allorf_1292127_1292204_lanthipeptide NZ_CP044444.1 Lanthipeptides: allorf_2627237_2627314_lanthipeptide NZ_CP048002.1 Lanthipeptides: allorf_3123788_3123865_lanthipeptide NZ_CP059405.1 Lanthipeptides: allorf_3176215_3176292_lanthipeptide NZ_CP059495.1 Lanthipeptides: allorf_1278377_1278454_lanthipeptide NZ_CP064091.1 Lanthipeptides: allorf_3836090_3836167_lanthipeptide NZ_CP083716.1 Lanthipeptides: allorf_110856_110933_lanthipeptide NZ_CP092110.1 Lanthipeptides: allorf_0704361_0704438_lanthipeptide NZ_CP092110.1 Lanthipeptides: allorf_0704361_0704438_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: allorf_101096_101173_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: allorf_101096_101173_lanthipeptide NZ_KB206086.1 Lanthipeptides: allorf_0474373_0474450_lanthipeptide NZ_KN050798.1 Lanthipeptides: allorf_0351480_0351557_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: allorf_337625_337702_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: allorf_337625_337702_lanthipeptide
Lanthipeptides: allorf_1210473_1210550_lanthipeptide
1
Q V I C P T N A T Y
10
Q V I C P T N A T Y
1
Q V I C P T N A T Y
10
allorf_344018_344200
Leader:
MKGGEIWNMKKNFSALYETSEQELKELVGG
Core:
Q N S V S I T T Y P I T N H I C P T I T V G C A C P Q R Q V
Core with dehydrations:
Q N Dha V Dha I Dhb Dhb Y P I Dhb N H I Cys P Dhb I Dhb V G Cys A Cys P Q R Q V

#### antiSMASH-DB 4.0 matches for allorf_344018_344200

100.0%
NZ_CP016371.1 and 25 others:
NZ_CP017775.1 Lanthipeptides: allorf_1362373_1362555_lanthipeptide NZ_CP018295.1 Lanthipeptides: allorf_1224462_1224620_lanthipeptide NZ_CP023075.1 Lanthipeptides: allorf_1280618_1280800_lanthipeptide NZ_CP027429.1 Lanthipeptides: allorf_2645650_2645832_lanthipeptide NZ_CP027429.1 Lanthipeptides: allorf_2645650_2645832_lanthipeptide NZ_CP033967.1 Lanthipeptides: allorf_3544503_3544661_lanthipeptide NZ_CP033967.1 Lanthipeptides: allorf_3544503_3544661_lanthipeptide NZ_CP035393.1 Lanthipeptides: allorf_1361512_1361694_lanthipeptide NZ_CP044133.1 Lanthipeptides: allorf_1285659_1285817_lanthipeptide NZ_CP044444.1 Lanthipeptides: allorf_2620740_2620922_lanthipeptide NZ_CP048002.1 Lanthipeptides: allorf_3117293_3117475_lanthipeptide NZ_CP059405.1 Lanthipeptides: allorf_3169717_3169899_lanthipeptide NZ_CP059495.1 Lanthipeptides: allorf_1271882_1272064_lanthipeptide NZ_CP064091.1 Lanthipeptides: allorf_3829595_3829777_lanthipeptide NZ_CP083716.1 Lanthipeptides: allorf_104358_104540_lanthipeptide NZ_CP092110.1 Lanthipeptides: allorf_0710754_0710936_lanthipeptide NZ_CP092110.1 Lanthipeptides: allorf_0710754_0710936_lanthipeptide NZ_CP116013.1 Lanthipeptides: allorf_0410910_0411092_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: allorf_107486_107668_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: allorf_107486_107668_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: allorf_050414_050596_lanthipeptide NZ_KB206086.1 Lanthipeptides: allorf_0467875_0468057_lanthipeptide NZ_KN050798.1 Lanthipeptides: allorf_0345012_0345170_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: allorf_344018_344200_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: allorf_344018_344200_lanthipeptide
Lanthipeptides: allorf_1203980_1204162_lanthipeptide
1
Q N S V S I T T Y P I T N H I C P T I T V G C A C P Q R Q V
30
Q N S V S I T T Y P I T N H I C P T I T V G C A C P Q R Q V
1
Q N S V S I T T Y P I T N H I C P T I T V G C A C P Q R Q V
30
93.3%
NC_023073.1 and 18 others:
NZ_CP010556.1 Lanthipeptides: allorf_1170865_1171047_lanthipeptide NZ_CP016395.1 Lanthipeptides: allorf_1266893_1267075_lanthipeptide NZ_CP023133.1 Lanthipeptides: allorf_0800979_0801161_lanthipeptide NZ_CP025341.1 Lanthipeptides: allorf_1207246_1207428_lanthipeptide NZ_CP028440.1 Lanthipeptides: allorf_1169247_1169429_lanthipeptide NZ_CP028440.1 Lanthipeptides: allorf_1169247_1169429_lanthipeptide NZ_CP031694.1 Lanthipeptides: allorf_3757607_3757789_lanthipeptide NZ_CP031694.1 Lanthipeptides: allorf_3757607_3757789_lanthipeptide NZ_CP065790.1 Lanthipeptides: allorf_1228836_1229018_lanthipeptide NZ_CP072310.1 Lanthipeptides: allorf_3340146_3340328_lanthipeptide NZ_CP074685.1 Lanthipeptides: allorf_1220760_1220942_lanthipeptide NZ_CP075054.1 Lanthipeptides: allorf_2702843_2703025_lanthipeptide NZ_CP075054.1 Lanthipeptides: allorf_2702843_2703025_lanthipeptide NZ_CP088300.1 Lanthipeptides: allorf_1174611_1174793_lanthipeptide NZ_CP090905.1 Lanthipeptides: allorf_1201177_1201359_lanthipeptide NZ_CP094618.1 Lanthipeptides: allorf_1135121_1135303_lanthipeptide NZ_CP119675.1 Lanthipeptides: allorf_2182837_2183019_lanthipeptide NZ_LN999829.1 Lanthipeptides: allorf_1186077_1186259_lanthipeptide
Lanthipeptides: allorf_1238739_1238921_lanthipeptide
1
Q N S V S I T T Y P I T N H I C P T I T V G C A C P Q R Q V
30
Q N S V S I T T P I T N H+C P T I T V G C A C P Q R Q V
1
Q N S V S I T T I P I T N H V C P T I T V G C A C P Q R Q V
30
66.7%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10235_lanthipeptide
Lanthipeptides: J7E20_RS10235_lanthipeptide
1
Q N S V S I T T Y P I T N H I C P T I T V G C A C P Q R Q V
30
Q N +S I T T P T H+C T+T V G C A C P Q+Q+
1
Q N L I S I T T I P F T-H L C A T V T V G C A C P Q K Q I
29
with 3 more sequence matches
23.5%
NZ_CP048048.1 and 2 others:
NZ_CP048050.1 Lanthipeptides: GW570_RS15170_lanthipeptide NZ_CP088267.1 Lanthipeptides: LRE50_RS16510_lanthipeptide
Lanthipeptides: GW571_RS15175_lanthipeptide
8
T Y P I T N H I C P T I T V G C A C P Q R Q
29
T+ +T +C T I A C Q
8
T F K L T V K V C R T I I T T T A C G S T Q
29
20.0%
NZ_JANIOB010000033.1:
Lanthipeptides: NQ113_RS28010_lanthipeptide
11
I T N H I C P T I
19
T N +C P T I
15
F T N R L C P T I
23
15.8%
NZ_KB907258.1:
Lanthipeptides: G358_RS0114910_lanthipeptide
2
N S V S I T T Y P I T N H I C P T I T
20
N S+ I+ Y + C P++
6
N S I R I S I Y K C L S L F C P S V A
24

#### MIBiG 4.0 matches for allorf_344018_344200

13.3%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
18
T I T V G C
23
T+T V C
18
T L T V E C
23

#### Lanthipeptide(s) for C6354_RS06025

C6354_RS18855
Leader:
MKKDFQALTPMTEEELKNLAGG
Core:
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
Core with dehydrations:
Dha D A Dhb P M Dhb V Dhb P Dhb Dhb I Dhb I P I Dha L A G Cys P Dhb Dhb K Cys A Dha I V Dha P Cys N D

#### antiSMASH-DB 4.0 matches for C6354_RS18855

100.0%
NC_023073.1 and 71 others:
NC_023073.1 Lanthipeptides: U722_RS19995_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide
Lanthipeptides: U722_RS19995_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
97.2%
NC_023073.1 and 71 others:
NC_023073.1 Lanthipeptides: U722_RS19990_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide
Lanthipeptides: U722_RS19990_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S+A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
94.4%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10245_lanthipeptide
Lanthipeptides: J7E20_RS10245_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S D A P M T+T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S D A A P M T I T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
with 60 more sequence matches
Only the first 10 are displayed here.
66.7%
NZ_JAMDLZ010000027.1:
Lanthipeptides: M5W82_RS15520_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T+T I P I S L A G C P T T K C A S I V S P C
8
T P L T V T I P I S L A G C P T T K C A S I V S P C K G
35
63.9%
NZ_WIXN01000006.1 and 1 other:
NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide
Lanthipeptides: GHD25_RS06900_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C
34
D A T P T P T T I I P+S L A C P T T C S S P C
1
E D A T P D T-H P T T I-I P V S L A V C P T T T C R S F S S P C
32
63.2%
NZ_AUCI01000015.1 and 1 other:
NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide
Lanthipeptides: G475_RS0114655_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S D P + T T+T I P I S G C P T T K C A S+V P C N D
3
S D Q Q P A S H P T T T V T I P I S A W G C P T T K C A S V V E P C N D
38
63.2%
NZ_FOXD01000022.1 and 1 other:
NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide
Lanthipeptides: BM124_RS15255_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S D P + T T+T I P I S G C P T T K C A S+V P C N D
3
S D Q Q P A S H P T T T V T I P I S A W G C P T T K C A S V V K P C N D
38
61.1%
NZ_CP063142.1 and 5 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide
Lanthipeptides: HPB58_RS21455_lanthipeptide
12
T I T I P I S L A G C P T T K C A S I V S P C N D
36
T+T I P I S L A C P T T+C A S I V S P C N D
8
T V T I P I S L A A C P T T Q C A S I V S P C N D
32
61.1%
NZ_LT745762.1 and 1 other:
NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide
Lanthipeptides: B2C77_RS21505_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T I I P+S L A C P T T K C A S+V P C N D
7
T P A T I-I P V S L A I C P T T K C A S V V K P C N D
33
58.3%
NZ_BOSN01000007.1 and 3 others:
NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide
Lanthipeptides: KJS43_RS18000_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T I I P+S L A C P T T K C A S+V P C N
7
T P A T I-I P V S L A I C P T T K C A S V V K P C N G
33
58.3%
NZ_BQME02000001.1 and 3 others:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide
Lanthipeptides: MFF31_RS04090_lanthipeptide
12
T I T I P I S L A G C P T T K C A S I V S P C N
35
T I I P I S L A C P T T+C A S I V S P C N
6
T I I I P I S L A A C P T T R C A S I V S P C N
29
55.6%
NZ_BQME02000001.1 and 1 other:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04085_lanthipeptide
Lanthipeptides: MFF31_RS04085_lanthipeptide
12
T I T I P I S L A G C P T T K C A S I V S P C N
35
T I I P I S L A C P T T+C A S I V S C N
6
T I I I P I S L A A C P T T R C A S I V S S C N
29
55.6%
NZ_KQ040792.1 and 1 other:
NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide
Lanthipeptides: WH45_RS23705_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T I I P+S L A C P T T+C A S I V C N
8
T P A T I-I P V S L A I C P T T R C A S I V E S C N G
34

#### MIBiG 4.0 matches for C6354_RS18855

24.3%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
13
I T I P I S L A G C P T T K C A S
29
+ + +S A C P T T K C S
19
V A V G V S A A F C P T T K C T S
35
19.4%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
22
C P T T K C A S
29
C P T T K C S
17
C P T T K C T S
24
C6354_RS18860
Leader:
MKKEFLALELMTEEELKELAGG
Core:
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
Core with dehydrations:
Dha E A Dhb P M Dhb V Dhb P Dhb Dhb I Dhb I P I Dha L A G Cys P Dhb Dhb K Cys A Dha I V Dha P Cys N D

#### antiSMASH-DB 4.0 matches for C6354_RS18860

100.0%
NC_023073.1 and 71 others:
NC_023073.1 Lanthipeptides: U722_RS19990_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide
Lanthipeptides: U722_RS19990_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
97.2%
NC_023073.1 and 71 others:
NC_023073.1 Lanthipeptides: U722_RS19995_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide
Lanthipeptides: U722_RS19995_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S+A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
97.2%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10240_lanthipeptide
Lanthipeptides: J7E20_RS10240_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S E A T P M T+T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S E A T P M T I T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
with 60 more sequence matches
Only the first 10 are displayed here.
91.7%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10245_lanthipeptide
Lanthipeptides: J7E20_RS10245_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S+A P M T+T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S D A A P M T I T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
66.7%
NZ_JAMDLZ010000027.1:
Lanthipeptides: M5W82_RS15520_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T+T I P I S L A G C P T T K C A S I V S P C
8
T P L T V T I P I S L A G C P T T K C A S I V S P C K G
35
63.9%
NZ_KQ040792.1 and 1 other:
NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide
Lanthipeptides: WH45_RS23705_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N
35
+E+T P T P T I I P+S L A C P T T+C A S I V C N
1
A E S T P-N G T P A T I-I P V S L A I C P T T R C A S I V E S C N
33
61.1%
NZ_CP063142.1 and 5 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide
Lanthipeptides: HPB58_RS21455_lanthipeptide
12
T I T I P I S L A G C P T T K C A S I V S P C N D
36
T+T I P I S L A C P T T+C A S I V S P C N D
8
T V T I P I S L A A C P T T Q C A S I V S P C N D
32
61.1%
NZ_LT745762.1 and 1 other:
NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide
Lanthipeptides: B2C77_RS21505_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T I I P+S L A C P T T K C A S+V P C N D
7
T P A T I-I P V S L A I C P T T K C A S V V K P C N D
33
61.1%
NZ_WIXN01000006.1 and 1 other:
NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide
Lanthipeptides: GHD25_RS06900_lanthipeptide
2
E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C
34
+A T P T P T T I I P+S L A C P T T C S S P C
2
D A T P D T-H P T T I-I P V S L A V C P T T T C R S F S S P C
32
60.5%
NZ_AUCI01000015.1 and 1 other:
NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide
Lanthipeptides: G475_RS0114655_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S+ P + T T+T I P I S G C P T T K C A S+V P C N D
3
S D Q Q P A S H P T T T V T I P I S A W G C P T T K C A S V V E P C N D
38
60.5%
NZ_FOXD01000022.1 and 1 other:
NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide
Lanthipeptides: BM124_RS15255_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S+ P + T T+T I P I S G C P T T K C A S+V P C N D
3
S D Q Q P A S H P T T T V T I P I S A W G C P T T K C A S V V K P C N D
38
58.3%
NZ_BOSN01000007.1 and 3 others:
NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide
Lanthipeptides: KJS43_RS18000_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T I I P+S L A C P T T K C A S+V P C N
7
T P A T I-I P V S L A I C P T T K C A S V V K P C N G
33
58.3%
NZ_BQME02000001.1 and 3 others:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide
Lanthipeptides: MFF31_RS04090_lanthipeptide
12
T I T I P I S L A G C P T T K C A S I V S P C N
35
T I I P I S L A C P T T+C A S I V S P C N
6
T I I I P I S L A A C P T T R C A S I V S P C N
29

#### MIBiG 4.0 matches for C6354_RS18860

24.3%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
13
I T I P I S L A G C P T T K C A S
29
+ + +S A C P T T K C S
19
V A V G V S A A F C P T T K C T S
35
19.4%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
22
C P T T K C A S
29
C P T T K C S
17
C P T T K C T S
24
C6354_RS06030
Leader:
MNEKMYRFAGDLREELEEISLS
Core:
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
Core with dehydrations:
E F Dha G G G G A E Q R G I Dha Q G N D G K L Cys Dhb L Dhb W E Cys G L Cys P Dhb H Dhb Cys W Cys

#### antiSMASH-DB 4.0 matches for C6354_RS06030

100.0%
NC_023073.1 and 65 others:
NC_023073.1 Lanthipeptides: U722_RS06170_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptide
Lanthipeptides: U722_RS06170_lanthipeptide
1
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
1
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
97.4%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10220_lanthipeptide
Lanthipeptides: J7E20_RS10220_lanthipeptide
1
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C+C
1
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C F C
38
86.8%
NZ_CP016371.1 and 7 others:
NZ_CP016371.1 Lanthipeptides: A5891_RS06120_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptide
Lanthipeptides: A5891_RS06120_lanthipeptide
6
G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
1
G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
33
with 92 more sequence matches
Only the first 10 are displayed here.
71.1%
NZ_BQME02000001.1 and 1 other:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04105_lanthipeptide
Lanthipeptides: MFF31_RS04105_lanthipeptide
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C-W C
38
A E Q R G I S Q G N D G K C T L T W E C +C P T T C W C
1
A E Q R G I S Q G N D G K Y C T L T W E C S V C P T L T C F W C
32
68.4%
NZ_CP063142.1 and 10 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21475_lanthipeptide NZ_FOXX01000007.1 Lanthipeptides: BM012_RS26100_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptide NZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptide NZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptide
Lanthipeptides: HPB58_RS21475_lanthipeptide
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E Q R G I S Q G N D G C T+T W E C +C P T H T C W C
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
68.4%
NZ_FOXD01000022.1 and 1 other:
NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15270_lanthipeptide
Lanthipeptides: BM124_RS15270_lanthipeptide
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E R G I S Q G N D G C T+T W E C G+C P T H T C W C
3
A E P R G I S Q G N D G D Y C T I T W E C G M C P T H T C W C
33
68.4%
NZ_KQ040792.1 and 1 other:
NZ_KQ040792.1 Lanthipeptides: WH45_RS23330_lanthipeptide
Lanthipeptides: WH45_RS23330_lanthipeptide
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E +G+S Q G N D G K+C T L T W E C G L C P T H T C+C
1
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F C
31
65.8%
NZ_BOSN01000007.1 and 3 others:
NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18005_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptide
Lanthipeptides: KJS43_RS18005_lanthipeptide
7
G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E G I S Q G N D G K C T+T W E C +C P T H T C W C
1
A A E P M G I S Q G N D G K Y C T I T W E C S I C P T H T C W C
32
65.8%
NZ_LT745762.1 and 1 other:
NZ_LT745762.1 Lanthipeptides: B2C77_RS00795_lanthipeptide
Lanthipeptides: B2C77_RS00795_lanthipeptide
7
G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E G I S Q G N D G K C T+T W E C +C P T H T C W C
1
A A E P M G I S Q G N D G K W C T V T W E C S I C P T H T C W C
32
63.2%
NZ_AUCI01000015.1 and 1 other:
NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114640_lanthipeptide
Lanthipeptides: G475_RS0114640_lanthipeptide
6
G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
E R G+S Q G N D G C T+T W E C G+C P T H T C W C
1
A D V E T R G L S Q G N D G D Y C T I T W E C G M C P T H T C W C
33
63.2%
NZ_CP101913.1 and 1 other:
NZ_CP101913.1 Lanthipeptides: NP440_RS09135_lanthipeptide
Lanthipeptides: NP440_RS09135_lanthipeptide
7
G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E G I S+ N D G K C T L T W E C +C P T H T C W C
1
A A E P M G I S E D N D G K Y C T L T W E C S I C P T H T C W C
32
63.2%
NZ_KV917378.1 and 1 other:
NZ_KV917378.1 Lanthipeptides: BK581_RS07320_lanthipeptide
Lanthipeptides: BK581_RS07320_lanthipeptide
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A+ +G I S Q G N D G K C T+T W E C +C P T H T C W C
1
A D V Q G I S Q G N D G K Y C T I T W E C S I C P T H T C W C
31
55.3%
NZ_CP040417.1 and 7 others:
NZ_CP040417.1 Lanthipeptides: FE328_RS09040_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide
Lanthipeptides: FE328_RS09040_lanthipeptide
5
G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W
37
G G R +S+G N G K+C T L T W E C G+C P+H T C+
1
G V G K W I R K L S K G N T G K V C T L T W E C G I C P S H T C F
33

#### MIBiG 4.0 matches for C6354_RS06030

23.7%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
16
G N D G K L C T L T W E C
28
G N G C T L T E C
11
G N K G A Y C T L T V E C
23
23.7%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
16
G N D G K L C T L T W E C
28
G N+G C T L T E C
13
G N N G G W C T L T K E C
25
15.8%
BGC0000580.3 (EGD17355.1):
Lasso peptide: xanthomonin II or xanthomonin I
6
G G A E Q R G I S Q
15
G G G I S Q
10
G G I T T L G I S Q
19
with 1 more sequence matches
12.8%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
22
C T L T W E C
28
C T L+ E C
28
C T L S K E C
34
allorf_337625_337702
Leader:
MRIHSIFIRMQGLYA
Core:
Q V I C P T N A T Y
Core with dehydrations:
Q V I Cys P Dhb N A Dhb Y

#### antiSMASH-DB 4.0 matches for allorf_337625_337702

100.0%
NZ_CP016371.1 and 22 others:
NZ_CP017775.1 Lanthipeptides: allorf_1370160_1370237_lanthipeptide NZ_CP018295.1 Lanthipeptides: allorf_1230930_1231007_lanthipeptide NZ_CP023075.1 Lanthipeptides: allorf_1287116_1287193_lanthipeptide NZ_CP027429.1 Lanthipeptides: allorf_2639262_2639339_lanthipeptide NZ_CP027429.1 Lanthipeptides: allorf_2639262_2639339_lanthipeptide NZ_CP033967.1 Lanthipeptides: allorf_3538116_3538193_lanthipeptide NZ_CP033967.1 Lanthipeptides: allorf_3538116_3538193_lanthipeptide NZ_CP044133.1 Lanthipeptides: allorf_1292127_1292204_lanthipeptide NZ_CP044444.1 Lanthipeptides: allorf_2627237_2627314_lanthipeptide NZ_CP048002.1 Lanthipeptides: allorf_3123788_3123865_lanthipeptide NZ_CP059405.1 Lanthipeptides: allorf_3176215_3176292_lanthipeptide NZ_CP059495.1 Lanthipeptides: allorf_1278377_1278454_lanthipeptide NZ_CP064091.1 Lanthipeptides: allorf_3836090_3836167_lanthipeptide NZ_CP083716.1 Lanthipeptides: allorf_110856_110933_lanthipeptide NZ_CP092110.1 Lanthipeptides: allorf_0704361_0704438_lanthipeptide NZ_CP092110.1 Lanthipeptides: allorf_0704361_0704438_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: allorf_101096_101173_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: allorf_101096_101173_lanthipeptide NZ_KB206086.1 Lanthipeptides: allorf_0474373_0474450_lanthipeptide NZ_KN050798.1 Lanthipeptides: allorf_0351480_0351557_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: allorf_337625_337702_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: allorf_337625_337702_lanthipeptide
Lanthipeptides: allorf_1210473_1210550_lanthipeptide
1
Q V I C P T N A T Y
10
Q V I C P T N A T Y
1
Q V I C P T N A T Y
10
allorf_344018_344200
Leader:
MKGGEIWNMKKNFSALYETSEQELKELVGG
Core:
Q N S V S I T T Y P I T N H I C P T I T V G C A C P Q R Q V
Core with dehydrations:
Q N Dha V Dha I Dhb Dhb Y P I Dhb N H I Cys P Dhb I Dhb V G Cys A Cys P Q R Q V

#### antiSMASH-DB 4.0 matches for allorf_344018_344200

100.0%
NZ_CP016371.1 and 25 others:
NZ_CP017775.1 Lanthipeptides: allorf_1362373_1362555_lanthipeptide NZ_CP018295.1 Lanthipeptides: allorf_1224462_1224620_lanthipeptide NZ_CP023075.1 Lanthipeptides: allorf_1280618_1280800_lanthipeptide NZ_CP027429.1 Lanthipeptides: allorf_2645650_2645832_lanthipeptide NZ_CP027429.1 Lanthipeptides: allorf_2645650_2645832_lanthipeptide NZ_CP033967.1 Lanthipeptides: allorf_3544503_3544661_lanthipeptide NZ_CP033967.1 Lanthipeptides: allorf_3544503_3544661_lanthipeptide NZ_CP035393.1 Lanthipeptides: allorf_1361512_1361694_lanthipeptide NZ_CP044133.1 Lanthipeptides: allorf_1285659_1285817_lanthipeptide NZ_CP044444.1 Lanthipeptides: allorf_2620740_2620922_lanthipeptide NZ_CP048002.1 Lanthipeptides: allorf_3117293_3117475_lanthipeptide NZ_CP059405.1 Lanthipeptides: allorf_3169717_3169899_lanthipeptide NZ_CP059495.1 Lanthipeptides: allorf_1271882_1272064_lanthipeptide NZ_CP064091.1 Lanthipeptides: allorf_3829595_3829777_lanthipeptide NZ_CP083716.1 Lanthipeptides: allorf_104358_104540_lanthipeptide NZ_CP092110.1 Lanthipeptides: allorf_0710754_0710936_lanthipeptide NZ_CP092110.1 Lanthipeptides: allorf_0710754_0710936_lanthipeptide NZ_CP116013.1 Lanthipeptides: allorf_0410910_0411092_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: allorf_107486_107668_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: allorf_107486_107668_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: allorf_050414_050596_lanthipeptide NZ_KB206086.1 Lanthipeptides: allorf_0467875_0468057_lanthipeptide NZ_KN050798.1 Lanthipeptides: allorf_0345012_0345170_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: allorf_344018_344200_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: allorf_344018_344200_lanthipeptide
Lanthipeptides: allorf_1203980_1204162_lanthipeptide
1
Q N S V S I T T Y P I T N H I C P T I T V G C A C P Q R Q V
30
Q N S V S I T T Y P I T N H I C P T I T V G C A C P Q R Q V
1
Q N S V S I T T Y P I T N H I C P T I T V G C A C P Q R Q V
30
93.3%
NC_023073.1 and 18 others:
NZ_CP010556.1 Lanthipeptides: allorf_1170865_1171047_lanthipeptide NZ_CP016395.1 Lanthipeptides: allorf_1266893_1267075_lanthipeptide NZ_CP023133.1 Lanthipeptides: allorf_0800979_0801161_lanthipeptide NZ_CP025341.1 Lanthipeptides: allorf_1207246_1207428_lanthipeptide NZ_CP028440.1 Lanthipeptides: allorf_1169247_1169429_lanthipeptide NZ_CP028440.1 Lanthipeptides: allorf_1169247_1169429_lanthipeptide NZ_CP031694.1 Lanthipeptides: allorf_3757607_3757789_lanthipeptide NZ_CP031694.1 Lanthipeptides: allorf_3757607_3757789_lanthipeptide NZ_CP065790.1 Lanthipeptides: allorf_1228836_1229018_lanthipeptide NZ_CP072310.1 Lanthipeptides: allorf_3340146_3340328_lanthipeptide NZ_CP074685.1 Lanthipeptides: allorf_1220760_1220942_lanthipeptide NZ_CP075054.1 Lanthipeptides: allorf_2702843_2703025_lanthipeptide NZ_CP075054.1 Lanthipeptides: allorf_2702843_2703025_lanthipeptide NZ_CP088300.1 Lanthipeptides: allorf_1174611_1174793_lanthipeptide NZ_CP090905.1 Lanthipeptides: allorf_1201177_1201359_lanthipeptide NZ_CP094618.1 Lanthipeptides: allorf_1135121_1135303_lanthipeptide NZ_CP119675.1 Lanthipeptides: allorf_2182837_2183019_lanthipeptide NZ_LN999829.1 Lanthipeptides: allorf_1186077_1186259_lanthipeptide
Lanthipeptides: allorf_1238739_1238921_lanthipeptide
1
Q N S V S I T T Y P I T N H I C P T I T V G C A C P Q R Q V
30
Q N S V S I T T P I T N H+C P T I T V G C A C P Q R Q V
1
Q N S V S I T T I P I T N H V C P T I T V G C A C P Q R Q V
30
66.7%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10235_lanthipeptide
Lanthipeptides: J7E20_RS10235_lanthipeptide
1
Q N S V S I T T Y P I T N H I C P T I T V G C A C P Q R Q V
30
Q N +S I T T P T H+C T+T V G C A C P Q+Q+
1
Q N L I S I T T I P F T-H L C A T V T V G C A C P Q K Q I
29
with 3 more sequence matches
23.5%
NZ_CP048048.1 and 2 others:
NZ_CP048050.1 Lanthipeptides: GW570_RS15170_lanthipeptide NZ_CP088267.1 Lanthipeptides: LRE50_RS16510_lanthipeptide
Lanthipeptides: GW571_RS15175_lanthipeptide
8
T Y P I T N H I C P T I T V G C A C P Q R Q
29
T+ +T +C T I A C Q
8
T F K L T V K V C R T I I T T T A C G S T Q
29
20.0%
NZ_JANIOB010000033.1:
Lanthipeptides: NQ113_RS28010_lanthipeptide
11
I T N H I C P T I
19
T N +C P T I
15
F T N R L C P T I
23
15.8%
NZ_KB907258.1:
Lanthipeptides: G358_RS0114910_lanthipeptide
2
N S V S I T T Y P I T N H I C P T I T
20
N S+ I+ Y + C P++
6
N S I R I S I Y K C L S L F C P S V A
24

#### MIBiG 4.0 matches for allorf_344018_344200

13.3%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
18
T I T V G C
23
T+T V C
18
T L T V E C
23

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.38 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.28 out of 27.78
Confidence: strong
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 24.65 out of 24.78
Confidence: strong
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05
Confidence: medium
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.57 out of 20.01
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.27 out of 23.79
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.96 out of 28.19
Confidence: medium
Additional weak hits (4):
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.13 out of 30.22
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 20.85 out of 30.22
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.99 out of 29.65
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.46 out of 30.11
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

C6354_RS18850 - Class II
  Cleavage pHMM score: -7.30
  RODEO score: 0
  Monoisotopic mass: 4023.2 Da
  Molecular weight: 4025.7 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4043.7 Da N = 1
C6354_RS18855 - Class II
  Cleavage pHMM score: 3.30
  RODEO score: 0
  Monoisotopic mass: 3389.7 Da
  Molecular weight: 3391.9 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3409.9 Da N = 1
    3427.9 Da N = 2
    3446.0 Da N = 3
    3464.0 Da N = 4
    3482.0 Da N = 5
    3500.0 Da N = 6
    3518.0 Da N = 7
    3536.1 Da N = 8
    3554.1 Da N = 9
C6354_RS18860 - Class II
  Cleavage pHMM score: 3.30
  RODEO score: 0
  Monoisotopic mass: 3403.7 Da
  Molecular weight: 3405.9 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3423.9 Da N = 1
    3442.0 Da N = 2
    3460.0 Da N = 3
    3478.0 Da N = 4
    3496.0 Da N = 5
    3514.0 Da N = 6
    3532.1 Da N = 7
    3550.1 Da N = 8
    3568.1 Da N = 9
C6354_RS06030 - Class II
  Cleavage pHMM score: -4.60
  RODEO score: 0
  Monoisotopic mass: 3892.7 Da
  Molecular weight: 3895.3 Da
  Number of bridges: 5
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3913.3 Da N = 1
allorf_330876_330977 - Class II
  Cleavage pHMM score: -5.60
  RODEO score: 0
  Monoisotopic mass: 1601.8 Da
  Molecular weight: 1602.8 Da
  Number of bridges: 1
allorf_335356_335517 - Class II
  Cleavage pHMM score: -2.00
  RODEO score: 0
  Monoisotopic mass: 3921.0 Da
  Molecular weight: 3923.7 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3941.7 Da N = 1
allorf_337625_337702 - Class II
  Cleavage pHMM score: -5.60
  RODEO score: 0
  Monoisotopic mass: 1072.5 Da
  Molecular weight: 1073.2 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1091.2 Da N = 1
allorf_344018_344200 - Class II
  Cleavage pHMM score: 2.00
  RODEO score: 0
  Monoisotopic mass: 3117.6 Da
  Molecular weight: 3119.6 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3137.6 Da N = 1
    3155.6 Da N = 2
    3173.6 Da N = 3
    3191.6 Da N = 4
C6354_RS18855 - Class II
  Cleavage pHMM score: 3.30
  RODEO score: 0
  Monoisotopic mass: 3389.7 Da
  Molecular weight: 3391.9 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3409.9 Da N = 1
    3427.9 Da N = 2
    3446.0 Da N = 3
    3464.0 Da N = 4
    3482.0 Da N = 5
    3500.0 Da N = 6
    3518.0 Da N = 7
    3536.1 Da N = 8
    3554.1 Da N = 9
C6354_RS18860 - Class II
  Cleavage pHMM score: 3.30
  RODEO score: 0
  Monoisotopic mass: 3403.7 Da
  Molecular weight: 3405.9 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3423.9 Da N = 1
    3442.0 Da N = 2
    3460.0 Da N = 3
    3478.0 Da N = 4
    3496.0 Da N = 5
    3514.0 Da N = 6
    3532.1 Da N = 7
    3550.1 Da N = 8
    3568.1 Da N = 9
C6354_RS06030 - Class II
  Cleavage pHMM score: -4.60
  RODEO score: 0
  Monoisotopic mass: 3892.7 Da
  Molecular weight: 3895.3 Da
  Number of bridges: 5
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3913.3 Da N = 1
allorf_337625_337702 - Class II
  Cleavage pHMM score: -5.60
  RODEO score: 0
  Monoisotopic mass: 1072.5 Da
  Molecular weight: 1073.2 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    1091.2 Da N = 1
allorf_344018_344200 - Class II
  Cleavage pHMM score: 2.00
  RODEO score: 0
  Monoisotopic mass: 3117.6 Da
  Molecular weight: 3119.6 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3137.6 Da N = 1
    3155.6 Da N = 2
    3173.6 Da N = 3
    3191.6 Da N = 4

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsR | Pleiotropic regulatory for antibiotic production
ArgR | Regulator of arginine biosynthesis genes
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
IolR | Regulator of the inositol catabolism
LexA variant 2 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
ZuR variant 1 | Zinc-responsive repressor

NZ_PVRO01000002.1 - Region 3 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 524,118 - 544,858 nt. (total: 20,741 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
C6354_RS07010: oxidoreductase

smcogs
  SMCOG1079: oxidoreductase

Transferases: aminotransferase
C6354_RS06995: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Hydrolases: hydrolase
C6354_RS07035: asparagine synthase (glutamine-hydrolyzing)

smcogs
  SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002458.3 |  | 0.49 | NRPS | alazopeptin | Streptacidiphilus griseoplanus
BGC0000885.3 |  | 0.47 | other (other) | 4-hydroxy-3-nitrosobenzamide | Streptomyces murayamaensis
BGC0000846.5 |  | 0.44 | other (other) | tabtoxin | Pseudomonas syringae
BGC0001374.5 |  | 0.42 | other (other) | thienodolin | Streptomyces albogriseolus
BGC0001880.3 |  | 0.41 | ribosomal | scytodecamide | Scytonema sp. UIC 10036
BGC0001488.3 |  | 0.38 | other (other) | 4-formylaminooxyvinylglycine | Pseudomonas fluorescens WH6
BGC0000720.3 |  | 0.35 | saccharide | tobramycin | Streptoalloteichus tenebrarius
BGC0002285.2 |  | 0.35 | ribosomal | aborycin | Streptomyces sp. ZS0098
BGC0001810.3 |  | 0.35 | PKS | trehangelin | Polymorphospora rubra
BGC0001735.5 |  | 0.35 | other (other) | pentostatine, vidarabine | Streptomyces antibioticus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002458.3 |  | 0.49 | NRPS | alazopeptin | Streptacidiphilus griseoplanus
BGC0000885.3 |  | 0.47 | other (other) | 4-hydroxy-3-nitrosobenzamide | Streptomyces murayamaensis
BGC0000846.5 |  | 0.44 | other (other) | tabtoxin | Pseudomonas syringae
BGC0001374.5 |  | 0.42 | other (other) | thienodolin | Streptomyces albogriseolus
BGC0001880.3 |  | 0.41 | ribosomal | scytodecamide | Scytonema sp. UIC 10036
BGC0001488.3 |  | 0.38 | other (other) | 4-formylaminooxyvinylglycine | Pseudomonas fluorescens WH6
BGC0000720.3 |  | 0.35 | saccharide | tobramycin | Streptoalloteichus tenebrarius
BGC0002285.2 |  | 0.35 | ribosomal | aborycin | Streptomyces sp. ZS0098
BGC0001810.3 |  | 0.35 | PKS | trehangelin | Polymorphospora rubra
BGC0001735.5 |  | 0.35 | other (other) | pentostatine, vidarabine | Streptomyces antibioticus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene |  | PSPP | C30 | acyclic | PP
triterpene | C30 carotenoid | diapophytoene | C30 | acyclic | none
triterpene |  | squalene | C30 | acyclic | none
tetraterpene | C40 carotenoid | phytoene | C40 | acyclic | none
triterpene |  | hydroxysqualene | C30 | acyclic | OH

Genes with terpene domains:
C6354_RS07030: PT_phytoene_like
Domain 1 (3 - 242): Prenyltransferase; Phytoene synthase like
Subtype: unknown

Reactions:
  FPP → PSPP
  FPP → diapophytoene
  FPP → squalene
  GGPP → phytoene
  PSPP → hydroxysqualene

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 23.16 out of 26.33
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.88 out of 27.78
Confidence: medium
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.10 out of 26.85
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.27 out of 28.19
Confidence: medium
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 26.99 out of 35.63
Confidence: medium
Additional weak hits (6):
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.61 out of 30.22
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.44 out of 31.73
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.16 out of 26.06
Confidence: weak
MexT
Description: Global virulence regulator
Species: Pseudomonas aeruginosa PAO1
Score: 18.38 out of 21.84
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 22.91 out of 32.74
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.48 out of 30.25
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
FPP | Farnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
PP | Diphosphate
PSPP | Presqualene diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
NrtR | NAD synthesis repressor
RutR | Regulator of the pyrimidine and purine metabolism
ZuR variant 1 | Zinc-responsive repressor

NZ_PVRO01000002.1 - Region 4 - PKS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 627,553 - 668,797 nt. (total: 41,245 nt) Show pHMM detection rules used
PKS-like: (t2pks2 or ksIII)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
C6354_RS07680: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acyltransferase aminotransferase
C6354_RS07635: aminotransferase

smcogs
  SMCOG1019: aminotransferase

C6354_RS07650: acyltransferase

smcogs
  SMCOG1141: acyltransferase

Hydrolases: deacetylase
C6354_RS07590: polysaccharide deacetylase

smcogs
  SMCOG1235: polysaccharide deacetylase

Ligases: synthase
C6354_RS07630: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

Translocases: permease
C6354_RS07675: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | PKS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002276.2 |  | 0.52 | NRPS | choline | Aspergillus nidulans FGSC A4
BGC0001928.2 |  | 0.46 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0002294.3 |  | 0.44 | other (other) | streptozotocin | Streptomyces achromogenes subsp. streptozoticus
BGC0000205.3 |  | 0.43 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0002150.2 |  | 0.42 | ribosomal | triculamin | Streptomyces triculaminicus
BGC0002151.2 |  | 0.42 | ribosomal | alboverticillin | Streptomyces griseocarneus
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000623.3 |  | 0.42 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0001206.5 |  | 0.42 | other (other) | indolmycin | Streptomyces griseus subsp. griseus
BGC0000551.5 |  | 0.42 | ribosomal | SapB | Streptomyces coelicolor A3(2)

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002276.2 |  | 0.52 | NRPS | choline | Aspergillus nidulans FGSC A4
BGC0001928.2 |  | 0.46 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0002294.3 |  | 0.44 | other (other) | streptozotocin | Streptomyces achromogenes subsp. streptozoticus
BGC0000205.3 |  | 0.43 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0002150.2 |  | 0.42 | ribosomal | triculamin | Streptomyces triculaminicus
BGC0002151.2 |  | 0.42 | ribosomal | alboverticillin | Streptomyces griseocarneus
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000623.3 |  | 0.42 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0001206.5 |  | 0.42 | other (other) | indolmycin | Streptomyces griseus subsp. griseus
BGC0000551.5 |  | 0.42 | ribosomal | SapB | Streptomyces coelicolor A3(2)

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.49 out of 25.88
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.50 out of 23.79
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.52 out of 26.06
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 25.91 out of 27.55
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.88 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.01 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.81 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.75 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.99 out of 26.06
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.83 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.27 out of 28.19
Confidence: medium
Additional weak hits (13):
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.59 out of 30.11
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.41 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.75 out of 26.06
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.28 out of 28.14
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.34 out of 30.25
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.97 out of 28.14
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.46 out of 26.06
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.28 out of 28.14
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.22 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.15 out of 26.06
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.48 out of 29.38
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.02 out of 28.14
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.32 out of 33.14
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM | Regulator of nitrogen-fixation genes
IolR | Regulator of the inositol catabolism
MogR | Repressor of flagellar motility genes
PsrA | Oleic acid responsive regulator
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_PVRO01000003.1 - Region 1 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 135,474 - 156,364 nt. (total: 20,891 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: carboxylase
C6354_RS09025: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase
C6354_RS09055: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

C6354_RS09060: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002284.3 |  | 0.38 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000639.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0000638.3 |  | 0.37 | terpene | carotenoid | Pantoea ananatis
BGC0000640.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC404

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002284.3 |  | 0.38 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000639.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0000638.3 |  | 0.37 | terpene | carotenoid | Pantoea ananatis
BGC0000640.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC404

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
C6354_RS09055: PT_FPPS_like
Domain 1 (33 - 296): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  DMAPP, IPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.59 out of 30.25
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.14 out of 27.78
Confidence: medium
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.81 out of 29.25
Confidence: medium
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator
SypG | Regulator of biofilm formation and host colonization

NZ_PVRO01000003.1 - Region 2 - transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 179,680 - 261,187 nt. (total: 81,508 nt) Show pHMM detection rules used
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase oxygenase
C6354_RS09275: 3-hydroxyisobutyrate dehydrogenase

smcogs
  SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

C6354_RS09300: NADH:flavin oxidoreductase/NADH oxidase

smcogs
  SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

C6354_RS09345: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

C6354_RS09350: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

C6354_RS09355: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

C6354_RS09365: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs
  SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

C6354_RS09370: cytochrome P450

smcogs
  SMCOG1007: cytochrome P450

C6354_RS09395: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

C6354_RS09475: aldo/keto reductase family oxidoreductase

smcogs
  SMCOG1039: aldo/keto reductase family oxidoreductase

Transferases: acylase transferase
C6354_RS09250: acetyl-CoA carboxylase, carboxyl transferase,

smcogs
  SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

C6354_RS09325: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: deacetylase hydrolase
C6354_RS09255: acetylornithine deacetylase

smcogs
  SMCOG1247: acetylornithine deacetylase

C6354_RS09390: metallo-beta-lactamase family protein

smcogs
  SMCOG1170: metallo-beta-lactamase family protein

Lyases: hydratase
C6354_RS09380: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase
C6354_RS09340: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

C6354_RS09360: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

C6354_RS09375: hydroxymethylglutaryl-CoA synthase

smcogs
  SMCOG1043: hydroxymethylglutaryl-CoA synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | transAT-PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000176.5 |  | 0.73 | PKS | difficidin | Bacillus velezensis FZB42
BGC0001164.3 |  | 0.62 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0001160.5 |  | 0.61 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0001254.3 |  | 0.61 | PKS | ACT-Toxin II | Alternaria alternata
BGC0000174.5 |  | 0.60 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0002056.3 |  | 0.57 | NRPS, PKS | peloruside A | sponge metagenome
BGC0001795.3 |  | 0.53 | PKS | swinholide A | Nostoc sp. UHCC 0450
BGC0000067.5 |  | 0.53 | PKS | geldanamycin | Streptomyces hygroscopicus subsp. duamyceticus
BGC0000205.3 |  | 0.52 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0001201.3 |  | 0.52 | terpene | eremophilene | Sorangium cellulosum So ce56

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000176.5 |  | 0.73 | PKS | difficidin | Bacillus velezensis FZB42
BGC0001164.3 |  | 0.62 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0001160.5 |  | 0.61 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0001254.3 |  | 0.61 | PKS | ACT-Toxin II | Alternaria alternata
BGC0000174.5 |  | 0.60 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0002056.3 |  | 0.57 | NRPS, PKS | peloruside A | sponge metagenome
BGC0001795.3 |  | 0.53 | PKS | swinholide A | Nostoc sp. UHCC 0450
BGC0000067.5 |  | 0.53 | PKS | geldanamycin | Streptomyces hygroscopicus subsp. duamyceticus
BGC0000205.3 |  | 0.52 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0001201.3 |  | 0.52 | terpene | eremophilene | Sorangium cellulosum So ce56

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.22 out of 18.57
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.92 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.19 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.89 out of 27.78
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 23.96 out of 24.78
Confidence: strong
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.30 out of 25.31
Confidence: medium
Additional weak hits (9):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.08 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.45 out of 26.06
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.61 out of 30.25
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 21.46 out of 30.97
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.34 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.26 out of 26.06
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 22.13 out of 30.97
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 26.71 out of 30.97
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.89 out of 32.93
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 179679 - 261187:
Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:
  (Me-ccmal - ccmal - ohmal - ccmal) + (ohmal - mal) + (Me-ccmal) + (mal)
Non-colinear ordering:
  C6354_RS09350 + C6354_RS09355 + C6354_RS09360 + C6354_RS09365

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
C6354_RS09325: mal
PKS_AT (4..281): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 83.3%
  inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 87.7
  inactive: 30.9
  Methoxymalonyl-CoA: 29.3
  Methylmalonyl-CoA: 21.7
  Propionyl-CoA: 16.5
  2-Methylbutyryl-CoA: 15.4
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Isobutyryl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0

C6354_RS09340: X
AMP-binding (15..363): X
nrpys: (unknown)

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    ALLLHIGGINTAPATYGTEKQTYGLTELGIFSTK
  Nearest Stachelhaus code(s):
    2,3-dohHda IGNPTGTIMK (74% 8Å match)
  Stachelhaus code match:
    90% (moderate)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CatR | H2O2-responsive repressor
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 2 | Repressor of DNA damage response
ToxT | Regulator of MSHA biosynthesis

NZ_PVRO01000005.1 - Region 1 - NRPS,transAT-PKS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 60,230 nt. (total: 60,230 nt) Show pHMM detection rules used
Region on contig edge.
transAT-PKS-like: cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS) and not PKS_AT)
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxygenase
C6354_RS11630: cytochrome P450

smcogs
  SMCOG1007: cytochrome P450

Hydrolases: protease
C6354_RS11650: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Ligases: ligase synthase
C6354_RS11615: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

C6354_RS11620: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

C6354_RS11625: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | transAT-PKS-like | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001244.3 |  |  | 0.55 | PKS | (-)-Mellein | Parastagonospora nodorum
BGC0001276.3 |  |  | 0.55 | PKS | 6-methylsalicyclic acid | Aspergillus terreus
BGC0001273.3 |  |  | 0.55 | PKS | asperlactone | Aspergillus ochraceus
BGC0002175.3 |  |  | 0.54 | PKS | YWA1 | Aspergillus oryzae RIB40
BGC0000107.3 |  |  | 0.54 | PKS | naphthopyrone | Aspergillus nidulans FGSC A4
BGC0002191.2 |  |  | 0.54 | PKS | prolipyrone B, gibepyrone D | Fusarium graminearum PH-1
BGC0000041.3 |  |  | 0.54 | PKS | oronofacic acid | Pseudomonas syringae
BGC0002154.2 |  |  | 0.53 | PKS | 1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene | Pyricularia oryzae 70-15
BGC0001257.3 |  |  | 0.53 | PKS | 1,3,6,8-tetrahydroxynaphthalene | Nodulisporium sp. ATCC74245
BGC0001254.3 |  |  | 0.52 | PKS | ACT-Toxin II | Alternaria alternata

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001244.3 |  | 0.61 | PKS | (-)-Mellein | Parastagonospora nodorum
BGC0001276.3 |  | 0.61 | PKS | 6-methylsalicyclic acid | Aspergillus terreus
BGC0001273.3 |  | 0.61 | PKS | asperlactone | Aspergillus ochraceus
BGC0002175.3 |  | 0.61 | PKS | YWA1 | Aspergillus oryzae RIB40
BGC0000107.3 |  | 0.61 | PKS | naphthopyrone | Aspergillus nidulans FGSC A4
BGC0002191.2 |  | 0.61 | PKS | prolipyrone B, gibepyrone D | Fusarium graminearum PH-1
BGC0000041.3 |  | 0.60 | PKS | oronofacic acid | Pseudomonas syringae
BGC0002154.2 |  | 0.60 | PKS | 1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene | Pyricularia oryzae 70-15
BGC0001257.3 |  | 0.60 | PKS | 1,3,6,8-tetrahydroxynaphthalene | Nodulisporium sp. ATCC74245
BGC0001254.3 |  | 0.60 | PKS | ACT-Toxin II | Alternaria alternata

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.47 out of 21.55
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.29 out of 27.78
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 24.10 out of 24.78
Confidence: strong
Additional weak hits (8):
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.04 out of 30.25
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.39 out of 30.25
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.54 out of 36.54
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 20.38 out of 28.14
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.53 out of 30.25
Confidence: weak
RicR
Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.62 out of 32.93
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.08 out of 39.62
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 60230:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (ohmal - mal) + (Ala - ccmal - ccmal - Me-ccmal) + (mal - mal)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
C6354_RS11620: Ala
Search NORINE for peptide: strict or relaxed
AMP-binding (492..896): Ala
nrpys: Ala

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    TFLTFDVSISEGNFMVAGEENIYGPTETSIYAAY
  Nearest Stachelhaus code(s):
    Ala DVSNMAIIYK (88% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArcA | Repressor of carbon oxidation
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 2 | Repressor of DNA damage response
ToxT | Regulator of MSHA biosynthesis

NZ_PVRO01000005.1 - Region 2 - NRPS,betalactone,transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 115,278 - 203,088 nt. (total: 87,811 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxygenase
C6354_RS12125: alcohol dehydrogenase

smcogs
  SMCOG1040: alcohol dehydrogenase

C6354_RS12140: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

C6354_RS12205: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

C6354_RS12225: cytochrome P450

smcogs
  SMCOG1007: cytochrome P450

C6354_RS12300: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

Transferases: acylase aminotransferase carboxylase kinase transferase
C6354_RS12120: PfkB domain protein

smcogs
  SMCOG1276: PfkB domain protein

C6354_RS12200: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

C6354_RS12245: aminotransferase class-III

smcogs
  SMCOG1013: aminotransferase class-III

C6354_RS12260: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs
  SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

C6354_RS12270: acetyl-CoA carboxylase, carboxyl transferase,

smcogs
  SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

C6354_RS12290: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Lyases: hydratase
C6354_RS12275: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase
C6354_RS12185: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

C6354_RS12190: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

C6354_RS12195: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

C6354_RS12240: 8-amino-7-oxononanoate synthase

smcogs
  SMCOG1109: 8-amino-7-oxononanoate synthase

C6354_RS12280: 2-isopropylmalate synthase

smcogs
  SMCOG1271: 2-isopropylmalate synthase

C6354_RS12295: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

C6354_RS12315: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

C6354_RS12320: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | transAT-PKS | NRPS | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | --- | ---
BGC0001090.5 |  |  |  |  | 1.50 | NRPS, PKS | bacillomycin D | Bacillus velezensis FZB42
BGC0001833.4 |  |  |  |  | 1.49 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002135.2 |  |  |  |  | 1.47 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001128.4 |  |  |  |  | 1.45 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4 |  |  |  |  | 1.44 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.4 |  |  |  |  | 1.43 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001098.5 |  |  |  |  | 1.42 | NRPS, PKS | iturin | Bacillus subtilis
BGC0002286.3 |  |  |  |  | 1.42 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  |  |  |  | 1.40 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001135.5 |  |  |  |  | 1.38 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001090.5 |  | 0.88 | NRPS, PKS | bacillomycin D | Bacillus velezensis FZB42
BGC0001098.5 |  | 0.84 | NRPS, PKS | iturin | Bacillus subtilis
BGC0000402.4 |  | 0.80 | NRPS | paenilarvin A, paenilarvin B, paenilarvin C | Paenibacillus larvae subsp. larvae DSM 25430
BGC0001103.5 |  | 0.77 | NRPS, PKS | mycosubtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001095.5 |  | 0.76 | NRPS | fengycin | Bacillus velezensis FZB42
BGC0001833.4 |  | 0.75 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002135.2 |  | 0.75 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001128.4 |  | 0.74 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4 |  | 0.73 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0002075.3 |  | 0.73 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 18.15 out of 18.46
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.21 out of 27.78
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.29 out of 27.55
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 20.32 out of 20.97
Confidence: strong
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 22.20 out of 24.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.82 out of 26.06
Confidence: medium
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.44 out of 32.93
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.67 out of 26.06
Confidence: medium
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.67 out of 20.01
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.83 out of 28.19
Confidence: medium
Additional weak hits (11):
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.61 out of 30.11
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.22 out of 28.14
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.65 out of 26.06
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.06 out of 29.38
Confidence: weak
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.01 out of 24.78
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.15 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.52 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.45 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.46 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.74 out of 26.06
Confidence: weak
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.44 out of 20.47
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 115277 - 203088:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (D-Tyr) + (Ile) + (fatty_acid - mal - Asn - D-Tyr) + (D-Asn - Pro - Glu - D-Ser) + (Thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 115277 - 192527:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (fatty_acid - mal - Asn - D-Tyr) + (D-Asn - Pro - Glu - D-Ser) + (Thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 175442 - 203088:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (D-Tyr) + (Ile)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
C6354_RS12185: Ser - Thr
Search NORINE for peptide: strict or relaxed
AMP-binding (267..674): Ser
nrpys: Ser

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    ser (Ser)
  Single AA prediction:
    ser (Ser)

Stachelhaus prediction details:
  Stachelhaus sequence:
    RWMTFDVSVWEWHFFASGEINLYGPTEATIDVSY
  Nearest Stachelhaus code(s):
    Ser DVWHFSLIDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1789..2188): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LNNHFDFSVWEGNQIFGGEINMYGITETTVHVTY
  Nearest Stachelhaus code(s):
    Thr DFWNIGMVHK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

C6354_RS12190: Tyr - Asn - Pro - Glu
Search NORINE for peptide: strict or relaxed
AMP-binding (268..662): Tyr
nrpys: Tyr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    Polar aromatic ring (Tyr, bOH-Tyr)
  Single AA prediction:
    tyr (Tyr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    SWKYFDAFILNGSTVVGGENNEYGPTENSVVSTF
  Nearest Stachelhaus code(s):
    Tyr DALSVGEVVK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1779..2174): Asn
nrpys: Asn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asn (Asn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWASFDLTVTSTKLIVGGECNEYGPTETVVGCMI
  Nearest Stachelhaus code(s):
    Asn DLTKIGEVGK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (3286..3683): Pro
nrpys: Pro

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
  Small clusters prediction:
    pro (Pro)
  Single AA prediction:
    pro (Pro)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LDQAFDVCYQESFFITAGEHNHYGPSETHVVSTY
  Nearest Stachelhaus code(s):
    Pro DVQFIAHVVK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (4325..4732): Glu
nrpys: Glu

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    gln (Gln)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LGLAFDASVKQADGLIGGETNVYGPTETCVDASV
  Nearest Stachelhaus code(s):
    Glu DAKDLGVVDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

C6354_RS12195: fatty_acid - Asn
Search NORINE for peptide: strict or relaxed
CAL_domain (36..478): fatty_acid
minowa: fatty_acid

Prediction, score:
  fatty_acid: 620.1
  NH2: 18.6
  shikimic_acid: 0.0
  Acetyl-CoA: 0.0
  AHBA: 0.0

AMP-binding (2956..3351): Asn
nrpys: Asn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asn (Asn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWASFDLTVTSTKLIVGGEFNEYGPTEAVVGCMI
  Nearest Stachelhaus code(s):
    Asn DLTKIGEVGK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

C6354_RS12200: mal
PKS_AT (6..290): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 62.5%
  inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 76.9
  inactive: 33.0
  Methoxymalonyl-CoA: 22.5
  Methylmalonyl-CoA: 11.9
  Propionyl-CoA: 10.3
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Isobutyryl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

C6354_RS12295: X
AMP-binding (12..445): X
nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:
  Predicted physicochemical class:
    N/A
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    NNIVF-GCVLGAHGIMAGSTIAYGQTEASPVITQ
  Nearest Stachelhaus code(s):
    Z-ahmohOrn FGLHIASTCK (56% 8Å match)
    Ile DGLFIGIPVK (32% 8Å match)
  Stachelhaus code match:
    60% (weak)

C6354_RS12315: Ile
Search NORINE for peptide: strict or relaxed
AMP-binding (473..866): Ile
nrpys: Ile

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    ile (Ile)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LNSGFDAVTFEGFLYVGGEYNIYGPTENTTFSTF
  Nearest Stachelhaus code(s):
    Ile DAFFYGITFK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

C6354_RS12320: Tyr
Search NORINE for peptide: strict or relaxed
AMP-binding (214..606): Tyr
nrpys: Tyr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    Polar aromatic ring (Tyr, bOH-Tyr)
  Single AA prediction:
    tyr (Tyr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TWRFFDGFVTSTIITLAGEANEYGPTENSVATTA
  Nearest Stachelhaus code(s):
    Tyr DGTITAEVAK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArgR | Regulator of arginine biosynthesis genes
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM | Regulator of nitrogen-fixation genes
LexA variant 2 | Repressor of DNA damage response
LexA variant 3 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
RpoN | Regulator of nitrogen assimilation and virulence
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_PVRO01000006.1 - Region 1 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 28,131 nt. (total: 28,131 nt) Show pHMM detection rules used
Region on contig edge.
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase electron transfer oxidoreductase reductase
C6354_RS12375: alcohol dehydrogenase

smcogs
  SMCOG1040: alcohol dehydrogenase

C6354_RS12390: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

C6354_RS12395: flavodoxin

smcogs
  SMCOG1134: flavodoxin

C6354_RS12400: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

C6354_RS12415: alkyl hydroperoxide reductase subunit

smcogs
  SMCOG1176: alkyl hydroperoxide reductase subunit

Ligases: synthase
C6354_RS12380: cobalamin synthesis protein/P47K family protein

smcogs
  SMCOG1178: cobalamin synthesis protein/P47K family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.71 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001135.5 |  | 0.68 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0000342.4 |  | 0.68 | NRPS | enniatin | Fusarium equiseti
BGC0001825.4 |  | 0.68 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001833.4 |  | 0.68 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001132.4 |  | 0.67 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.4 |  | 0.66 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.66 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  | 0.66 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0000307.4 |  | 0.65 | NRPS | AbT1 | Aureobasidium pullulans

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002135.2 |  | 0.71 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001135.5 |  | 0.68 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0000342.4 |  | 0.68 | NRPS | enniatin | Fusarium equiseti
BGC0001825.4 |  | 0.68 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001833.4 |  | 0.68 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001132.4 |  | 0.67 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001128.4 |  | 0.66 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.66 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  | 0.66 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0000307.4 |  | 0.65 | NRPS | AbT1 | Aureobasidium pullulans

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.40 out of 20.97
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.88 out of 23.79
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.55 out of 29.38
Confidence: medium
Additional weak hits (6):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.84 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.40 out of 26.06
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 23.23 out of 36.54
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.74 out of 32.74
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.89 out of 29.38
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 22.50 out of 35.63
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 1, location 0 - 28131:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Glu - Leu)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
C6354_RS12325: Glu - Leu
Search NORINE for peptide: strict or relaxed
AMP-binding (465..867): Glu
nrpys: Glu

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    gln (Gln)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LSLAFDASVKQADGLIGGETNVYGPTETCVDASV
  Nearest Stachelhaus code(s):
    Glu DAKDLGVVDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1511..1908): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TNTSFDAFMFDGMIMFGGELHMYGPSESTVFATY
  Nearest Stachelhaus code(s):
    Leu DAFMMGMVFK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
FuR variant 1 | Ferric Uptake Regulator
IolR | Regulator of the inositol catabolism

NZ_PVRO01000006.1 - Region 2 - azole-containing-RiPP
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 39,485 - 69,221 nt. (total: 29,737 nt) Show pHMM detection rules used
azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Azole RiPPs
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: glucosidase hydrolase
C6354_RS12580: Alpha-glucosidase

smcogs
  SMCOG1257: Alpha-glucosidase

C6354_RS12595: amidohydrolase

smcogs
  SMCOG1244: amidohydrolase

Lyases: dehydratase
C6354_RS12560: Lantibiotic dehydratase domain protein

smcogs
  SMCOG1155: Lantibiotic dehydratase domain protein

Translocases: permease
C6354_RS12485: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | azole-containing-RiPP | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002311.3 |  | 0.51 | ribosomal | cutimycin | Cutibacterium acnes KPA171202
BGC0001146.5 |  | 0.50 | ribosomal | cyclothiazomycin C | Streptomyces sp. NRRL WC-3908
BGC0000606.5 |  | 0.49 | ribosomal | lactazole | Streptomyces lactacystinaeus
BGC0001174.4 |  | 0.47 | ribosomal | corynazolicin | Corynebacterium urealyticum DSM 7111
BGC0000605.5 |  | 0.46 | ribosomal | GE37468 | Streptomyces sp. ATCC 55365
BGC0000607.5 |  | 0.45 | ribosomal | micrococcin P1 | Macrococcus caseolyticus
BGC0002635.2 |  | 0.44 | ribosomal | daspyromycin A, daspyromycin B | Actinokineospora diospyrosa
BGC0000565.5 |  | 0.44 | ribosomal | goadsporin | Streptomyces sp. TP-A0584
BGC0001640.3 |  | 0.43 | ribosomal | kocurin | Kocuria rosea
BGC0000613.5 |  | 0.43 | ribosomal | thiomuracin A | Nonomuraea sp. Bp3714-39

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002311.3 |  | 0.51 | ribosomal | cutimycin | Cutibacterium acnes KPA171202
BGC0001146.5 |  | 0.50 | ribosomal | cyclothiazomycin C | Streptomyces sp. NRRL WC-3908
BGC0000606.5 |  | 0.49 | ribosomal | lactazole | Streptomyces lactacystinaeus
BGC0001174.4 |  | 0.47 | ribosomal | corynazolicin | Corynebacterium urealyticum DSM 7111
BGC0000605.5 |  | 0.46 | ribosomal | GE37468 | Streptomyces sp. ATCC 55365
BGC0000607.5 |  | 0.45 | ribosomal | micrococcin P1 | Macrococcus caseolyticus
BGC0002635.2 |  | 0.44 | ribosomal | daspyromycin A, daspyromycin B | Actinokineospora diospyrosa
BGC0000565.5 |  | 0.44 | ribosomal | goadsporin | Streptomyces sp. TP-A0584
BGC0001640.3 |  | 0.43 | ribosomal | kocurin | Kocuria rosea
BGC0000613.5 |  | 0.43 | ribosomal | thiomuracin A | Nonomuraea sp. Bp3714-39

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.99 out of 30.25
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.62 out of 26.06
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.26 out of 19.26
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.40 out of 27.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.18 out of 28.19
Confidence: medium
Additional weak hits (2):
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.23 out of 33.73
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 26.34 out of 33.14
Confidence: weak
(Thi)azol(in)e containing peptide predictions
Lists the possible core peptides for each biosynthetic enzyme. Predicted tail sequences are also shown, if present.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.
No core peptides found.
TFBS Finder
Azole RiPPs
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator
MogR | Repressor of flagellar motility genes
ZuR variant 1 | Zinc-responsive repressor

Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its possible molecular weights and the scores for cleavage site prediction and RODEO. If relevant, other features, such as macrocycle and amidation, will also be listed.
No core peptides found.
NZ_PVRO01000008.1 - Region 1 - T3PKS,transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 28,400 nt. (total: 28,400 nt) Show pHMM detection rules used
Region on contig edge.
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
C6354_RS14280: alcohol dehydrogenase

smcogs
  SMCOG1040: alcohol dehydrogenase

Transferases: acylase
C6354_RS14205: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

C6354_RS14210: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: hydrolase
C6354_RS14220: metallo-beta-lactamase family protein

smcogs
  SMCOG1170: metallo-beta-lactamase family protein

C6354_RS14300: beta-lactamase

smcogs
  SMCOG1053: beta-lactamase

Lyases: hydratase
C6354_RS14185: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

C6354_RS14190: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

Ligases: synthase
C6354_RS14175: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

C6354_RS14195: hydroxymethylglutaryl-CoA synthase

smcogs
  SMCOG1043: hydroxymethylglutaryl-CoA synthase

C6354_RS14275: 8-amino-7-oxononanoate synthase

smcogs
  SMCOG1109: 8-amino-7-oxononanoate synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | transAT-PKS | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0002191.2 |  |  | 0.60 | PKS | prolipyrone B, gibepyrone D | Fusarium graminearum PH-1
BGC0001164.3 |  |  | 0.58 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0001257.3 |  |  | 0.57 | PKS | 1,3,6,8-tetrahydroxynaphthalene | Nodulisporium sp. ATCC74245
BGC0000107.3 |  |  | 0.55 | PKS | naphthopyrone | Aspergillus nidulans FGSC A4
BGC0001244.3 |  |  | 0.55 | PKS | (-)-Mellein | Parastagonospora nodorum
BGC0001276.3 |  |  | 0.54 | PKS | 6-methylsalicyclic acid | Aspergillus terreus
BGC0001275.3 |  |  | 0.54 | PKS | 6-methylsalicyclic acid | Glarea lozoyensis
BGC0001273.3 |  |  | 0.54 | PKS | asperlactone | Aspergillus ochraceus
BGC0002175.3 |  |  | 0.54 | PKS | YWA1 | Aspergillus oryzae RIB40
BGC0002154.2 |  |  | 0.53 | PKS | 1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene | Pyricularia oryzae 70-15

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002191.2 |  | 0.64 | PKS | prolipyrone B, gibepyrone D | Fusarium graminearum PH-1
BGC0001164.3 |  | 0.63 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0001257.3 |  | 0.62 | PKS | 1,3,6,8-tetrahydroxynaphthalene | Nodulisporium sp. ATCC74245
BGC0000107.3 |  | 0.61 | PKS | naphthopyrone | Aspergillus nidulans FGSC A4
BGC0001244.3 |  | 0.61 | PKS | (-)-Mellein | Parastagonospora nodorum
BGC0001276.3 |  | 0.61 | PKS | 6-methylsalicyclic acid | Aspergillus terreus
BGC0001275.3 |  | 0.61 | PKS | 6-methylsalicyclic acid | Glarea lozoyensis
BGC0001273.3 |  | 0.61 | PKS | asperlactone | Aspergillus ochraceus
BGC0002175.3 |  | 0.61 | PKS | YWA1 | Aspergillus oryzae RIB40
BGC0002154.2 |  | 0.60 | PKS | 1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene | Pyricularia oryzae 70-15

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.60 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.14 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.62 out of 26.06
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.78 out of 20.97
Confidence: strong
Additional weak hits (8):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.67 out of 26.06
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 26.07 out of 39.62
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.67 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.08 out of 26.06
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.22 out of 28.14
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.16 out of 32.74
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.96 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.51 out of 26.06
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS substrates
TFBS Finder
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
C6354_RS14205: mal
PKS_AT (4..282): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 87.5%
  inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 87.4
  inactive: 28.2
  Methoxymalonyl-CoA: 23.4
  Methylmalonyl-CoA: 10.9
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Propionyl-CoA: 0.0
  Isobutyryl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

C6354_RS14210: mal
PKS_AT (7..293): mal
ATSignature: (unknown)
No matches above 50%
minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 38.6
  inactive: 27.0
  Methoxymalonyl-CoA: 19.2
  Benzoyl-CoA: 11.5
  Methylmalonyl-CoA: 9.7
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Propionyl-CoA: 0.0
  Isobutyryl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis