GCF_002798305.1 - 4 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_PCGR01000001.1 (Chryseomicrobium excrementi)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	terpene-precursor	312,586	333,470

NZ_PCGR01000002.1 (Chryseomicrobium excrementi)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 3.1	terpene	17,071	37,874

NZ_PCGR01000003.1 (Chryseomicrobium excrementi)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 4.1	lanthipeptide-class-ii	105,364	133,255	Medium	staphylococcin C55 α/staphylococcin C55 β	ribosomal:RiPP:Lanthipeptide
Region 4.2	terpene	271,934	292,767	Medium	carotenoid	terpene

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	terpene-precursor	312,586	333,470
Region 3.1	terpene	17,071	37,874
Region 4.1	lanthipeptide-class-ii	105,364	133,255	Medium	staphylococcin C55 α/staphylococcin C55 β	ribosomal:RiPP:Lanthipeptide
Region 4.2	terpene	271,934	292,767	Medium	carotenoid	terpene

No secondary metabolite regions were found in these records:: NZ_PCGR01000010.1 (Chryseomicrobium excrementi); NZ_PCGR01000004.1 (Chryseomicrobium excrementi); NZ_PCGR01000005.1 (Chryseomicrobium excrementi); NZ_PCGR01000006.1 (Chryseomicrobium excrementi); NZ_PCGR01000007.1 (Chryseomicrobium excrementi); NZ_PCGR01000008.1 (Chryseomicrobium excrementi); NZ_PCGR01000009.1 (Chryseomicrobium excrementi)

Compact view

NZ_PCGR01000001.1 - Region 1 - terpene-precursor

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Location: 312,586 - 333,470 nt. (total: 20,885 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: carboxylase

CQS04_RS01635: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Hydrolases: peptidase

CQS04_RS01620: methionine aminopeptidase

smcogs: SMCOG1172: methionine aminopeptidase

Ligases: synthase synthetase

CQS04_RS01665: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

CQS04_RS01670: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0000665.5	0.41	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0002284.3	0.40	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000668.5	0.40	other (other), terpene	12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole	Hapalosiphon welwitschii UTEX B 1830
BGC0001594.3	0.39	other (other)	fischerindole L	Fischerella muscicola UTEX 1829
BGC0000666.5	0.38	terpene	xiamycin A	Streptomyces sp. SCSIO 02999
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0000665.5	0.41	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0002284.3	0.40	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000668.5	0.40	other (other), terpene	12-epi-hapalindole C isonitrile, 12-epi-hapalindole E, 12-epi-fischerindole U isonitrile, fischerindole L, 12-epi-fischerindole I isonitrile, welwitindolinone A isonitrile, welwitindolinone B isothiocyanate, welwitindolinone C isothiocyanate, N-methylwelwitindolinone C isothiocyanate, N-methylwelwitinsolinone C isonitrile, 3-epi-welwitindolinone B isothiocyanate, 3-(Z-2'-isocyanoethenyl)-indole	Hapalosiphon welwitschii UTEX B 1830
BGC0001594.3	0.39	other (other)	fischerindole L	Fischerella muscicola UTEX 1829
BGC0000666.5	0.38	terpene	xiamycin A	Streptomyces sp. SCSIO 02999
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

CQS04_RS01665: PT_FPPS_like

Domain 1 (33 - 293): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.59 out of 27.78

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.46 out of 28.19

Confidence: strong

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.67 out of 32.93

Confidence: medium

Additional weak hits (3):

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.94 out of 22.40

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.31 out of 25.75

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 3	Repressor of DNA damage response
ZuR variant 1	Zinc-responsive repressor

NZ_PCGR01000002.1 - Region 1 - terpene

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Location: 17,071 - 37,874 nt. (total: 20,804 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: deacetylase hydrolase

CQS04_RS04655: amidohydrolase

smcogs: SMCOG1244: amidohydrolase

CQS04_RS04725: acetylornithine deacetylase

smcogs: SMCOG1247: acetylornithine deacetylase

Lyases: cyclase

CQS04_RS04680: diguanylate cyclase

smcogs: SMCOG1025: diguanylate cyclase

Isomerases: racemase

CQS04_RS04670: mandelate racemase/muconate lactonizing enzyme

smcogs: SMCOG1268: mandelate racemase/muconate lactonizing enzyme

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002343.3	0.34	other (other), ribosomal	ammosester A, ammosester B, ammosester C, ammosamaic acid cogener	Streptomyces uncialis
BGC0000334.4	0.31	NRPS	cyclosporin A	Tolypocladium inflatum NRRL 8044
BGC0002386.2	0.31	NRPS, PKS	cyclo(n-Me-L-Leu-L-Val), cyclo(n-Me-L-Leu-L-Leu), cyclo(n-Me-L-Leu-L-Ile)	Sorangium cellulosum So0157-2
BGC0000938.5	0.31	other (aminocoumarin)	fosfomycin	Streptomyces fradiae
BGC0001733.3	0.29	ribosomal	PcpA	Pleurocapsa sp. PCC 7327
BGC0000651.5	0.28	terpene	KS-505a	Streptomyces argenteolus
BGC0002026.3	0.27	NRPS, PKS	thaxteramide A1, thaxteramide A2, thaxteramide B1, thaxteramide B2	Jahnella sp. MSr9139
BGC0000367.5	0.27	NRPS	gramicidin	Brevibacillus brevis NBRC 100599
BGC0002126.3	0.27	NRPS	hypeptin	Lysobacter sp. K5869
BGC0002025.4	0.27	NRPS, PKS	thaxteramide C	Jahnella sp. MSr9139

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002343.3	0.34	other (other), ribosomal	ammosester A, ammosester B, ammosester C, ammosamaic acid cogener	Streptomyces uncialis
BGC0000334.4	0.31	NRPS	cyclosporin A	Tolypocladium inflatum NRRL 8044
BGC0002386.2	0.31	NRPS, PKS	cyclo(n-Me-L-Leu-L-Val), cyclo(n-Me-L-Leu-L-Leu), cyclo(n-Me-L-Leu-L-Ile)	Sorangium cellulosum So0157-2
BGC0000938.5	0.31	other (aminocoumarin)	fosfomycin	Streptomyces fradiae
BGC0001733.3	0.29	ribosomal	PcpA	Pleurocapsa sp. PCC 7327
BGC0000651.5	0.28	terpene	KS-505a	Streptomyces argenteolus
BGC0002026.3	0.27	NRPS, PKS	thaxteramide A1, thaxteramide A2, thaxteramide B1, thaxteramide B2	Jahnella sp. MSr9139
BGC0000367.5	0.27	NRPS	gramicidin	Brevibacillus brevis NBRC 100599
BGC0002126.3	0.27	NRPS	hypeptin	Lysobacter sp. K5869
BGC0002025.4	0.27	NRPS, PKS	thaxteramide C	Jahnella sp. MSr9139

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	C30 carotenoid	diapophytoene	C30	acyclic	none
triterpene		squalene	C30	acyclic	none
triterpene		PSPP	C30	acyclic	PP
tetraterpene	C40 carotenoid	phytoene	C40	acyclic	none
triterpene		hydroxysqualene	C30	acyclic	OH

Genes with terpene domains:

CQS04_RS04685: PT_phytoene_like

Domain 1 (3 - 225): Prenyltransferase; Phytoene synthase like

Subtype: unknown

Reactions:: FPP → diapophytoene; FPP → squalene; FPP → PSPP; GGPP → phytoene; PSPP → hydroxysqualene

Transcription Factor Binding Sites

Binding sites found:

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 27.81 out of 29.38

Confidence: strong

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.54 out of 29.38

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 26.44 out of 28.19

Confidence: strong

BldD

Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 20.41 out of 23.43

Confidence: medium

Additional weak hits (3):

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.65 out of 20.01

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.61 out of 32.74

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.31 out of 29.38

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate
GGPP	Geranylgeranyl diphosphate
PP	Diphosphate
PSPP	Presqualene diphosphate

TFBS definitions

Regulator	Description
BldD	Development and antibiotic global regulator
FuR variant 1	Ferric Uptake Regulator
ZuR variant 1	Zinc-responsive repressor

NZ_PCGR01000003.1 - Region 1 - lanthipeptide-class-ii

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Location: 105,364 - 133,255 nt. (total: 27,892 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

CQS04_RS09565: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

CQS04_RS09645: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Lyases: cyclase

CQS04_RS09630: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

CQS04_RS09640: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000520.5	0.80	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0000555.3	0.71	ribosomal	staphylococcin C55 α, staphylococcin C55 β	Staphylococcus aureus
BGC0001229.4	0.63	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0002110.3	0.61	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0002276.2	0.54	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000517.4	0.52	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0000552.3	0.51	ribosomal	SmbA, SmbB	Streptococcus mutans
BGC0001210.5	0.51	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0001391.3	0.50	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000497.3	0.50	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000520.5	0.80	ribosomal	lacticin 3147 A1, lacticin 3147 A2	Lactococcus lactis
BGC0000555.3	0.71	ribosomal	staphylococcin C55 α, staphylococcin C55 β	Staphylococcus aureus
BGC0001229.4	0.63	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0002110.3	0.61	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0002276.2	0.54	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000517.4	0.52	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0000552.3	0.51	ribosomal	SmbA, SmbB	Streptococcus mutans
BGC0001210.5	0.51	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0001391.3	0.50	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000497.3	0.50	ribosomal	BHT-Aα, BHT-Aβ	Streptococcus ratti

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for CQS04_RS09630

CQS04_RS09620

Leader:

MKNELLKQEQVTWFEEVADQQFDDDVFGA

Core:

CTTNTFSLSDYWGNNGNWCTATHECMSWCK

Core with dehydrations:

CysDhbDhbNDhbFDhaLDhaDYWGNNGNWCysDhbADhbHECysMDhaWCysK

antiSMASH-DB 4.0 matches for CQS04_RS09620

100.0%

NZ_PCGR01000003.1and 1 other:

NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09620_lanthipeptide

Lanthipeptides: CQS04_RS09620_lanthipeptide

CTTNTFSLSDYWGNNGNWCTATHECMSWCK

93.3%

NZ_AP026714.1and 21 others:

NZ_AP026714.1 Lanthipeptides: PO853_RS06515_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11265_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11265_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03985_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03985_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09810_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09810_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00085_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00085_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07700_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07700_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03735_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03735_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00120_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00120_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07750_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07750_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04675_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04675_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07990_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07990_lanthipeptide

Lanthipeptides: PO853_RS06515_lanthipeptide

CTTNTFSLSDYWGNNGNWCTATHECMSWCK

CTTNTFSLSDYWGN GNWCTATHECM WCK

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

93.3%

NZ_CP061868.1and 1 other:

NZ_CP061868.1 Lanthipeptides: IE339_RS06330_lanthipeptide

Lanthipeptides: IE339_RS06330_lanthipeptide

CTTNTFSLSDYWGNNGNWCTATHECMSWCK

CTTNTFSLSDYWGN G WCTATHECMSWCK

CTTNTFSLSDYWGNKGGWCTATHECMSWCK

with 104 more sequence matches

Only the first 10 are displayed here.

93.3%

NZ_FMPI01000012.1and 1 other:

NZ_FMPI01000012.1 Lanthipeptides: BJR39_RS08305_lanthipeptide

Lanthipeptides: BJR39_RS08305_lanthipeptide

CTTNTFSLSDYWGNNGNWCTATHECMSWCK

C+TNTFSLSDYWGNNGNWCTA+HECMSWCK

CSTNTFSLSDYWGNNGNWCTASHECMSWCK

90.0%

NZ_BLIS01000009.1and 7 others:

NZ_BLIS01000009.1 Lanthipeptides: GVO03_RS04820_lanthipeptideNZ_LR134317.1 Lanthipeptides: EL136_RS01685_lanthipeptideNZ_LR134317.1 Lanthipeptides: EL136_RS01685_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02620_lanthipeptideNZ_QRWZ01000002.1 Lanthipeptides: DWX18_RS02620_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01935_lanthipeptideNZ_SPGD01000003.1 Lanthipeptides: FGQ50_RS01935_lanthipeptide

Lanthipeptides: GVO03_RS04820_lanthipeptide

CTTNTFSLSDYWGNNGNWCTATHECMSWCK

CTTNTFSLSDYWGN GNWCT THECM+WCK

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

90.0%

NZ_NUIO01000031.1and 1 other:

NZ_NUIO01000031.1 Lanthipeptides: CN977_RS23160_lanthipeptide

Lanthipeptides: CN977_RS23160_lanthipeptide

CTTNTFSLSDYWGNNGNWCTATHECMSWCK

CTTNTFSLSDYWGN+G+WCTATHEC+SWCK

CTTNTFSLSDYWGNDGSWCTATHECLSWCK

86.7%

NZ_CACZYW010000004.1and 1 other:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02825_lanthipeptide

Lanthipeptides: HUF10_RS02825_lanthipeptide

CTTNTFSLSDYWGNNGNWCTATHECMSWCK

C+TNTFSLSDYWGNNGNWCT +HECM+WCK

CSTNTFSLSDYWGNNGNWCTLSHECMAWCK

86.7%

NZ_CP027862.1and 1 other:

NZ_CP027862.1 Lanthipeptides: allorf_0097945_0098112_lanthipeptide

Lanthipeptides: allorf_0097945_0098112_lanthipeptide

CTTNTFSLSDYWGNNGNWCTATHECMSWCK

C+TNTFSLSDYWGN G WCT THECMSWCK

CSTNTFSLSDYWGNRGYWCTLTHECMSWCK

86.7%

NZ_CP051884.1and 2 others:

NZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptide

Lanthipeptides: HGK68_RS15125_lanthipeptide

CTTNTFSLSDYWGNNGNWCTATHECMSWCK

C+TNTFSLSDYWGNNG CT THECMSWCK

CSTNTFSLSDYWGNNGWLCTITHECMSWCK

83.3%

NZ_CP034414.1and 1 other:

NZ_CP034414.1 Lanthipeptides: EI692_RS18440_lanthipeptide

Lanthipeptides: EI692_RS18440_lanthipeptide

CTTNTFSLSDYWGNNGNWCTATHECMSWCK

C+TNTFSLSDYWGN G WCT +HECMSWCK

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

83.3%

NZ_FNHR01000005.1and 1 other:

NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05590_lanthipeptide

Lanthipeptides: BLQ37_RS05590_lanthipeptide

CTTNTFSLSDYWGNNGNWCTATHECMSWCK

C+TNTFSLSDY GNNGNWCT +HECM+WCK

CSTNTFSLSDYMGNNGNWCTISHECMAWCK

83.3%

NZ_MIFN01000022.1and 1 other:

NZ_MIFN01000022.1 Lanthipeptides: BHL26_RS15350_lanthipeptide

Lanthipeptides: BHL26_RS15350_lanthipeptide

CTTNTFSLSDYWGNNGNWCTATHECMSWCK

CTTNTFSLSDYWGN+G+WC+ +HECMSWCK

CTTNTFSLSDYWGNDGSWCSLSHECMSWCK

83.3%

NZ_QGEE01000020.1and 5 others:

NZ_QGEE01000020.1 Lanthipeptides: DKP74_RS06160_lanthipeptideNZ_QGEF01000018.1 Lanthipeptides: DKP75_RS05595_lanthipeptideNZ_QGEF01000018.1 Lanthipeptides: DKP75_RS05595_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05380_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05380_lanthipeptide

Lanthipeptides: DKP74_RS06160_lanthipeptide

CTTNTFSLSDYWGNNGNWCTATHECMSWCK

C+TNTFSLSDYWGN GNWCT +HECM+WCK

CSTNTFSLSDYWGNRGNWCTLSHECMAWCK

MIBiG 4.0 matches for CQS04_RS09620

66.7%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

CTTNTFSLSDYWGNNGNWCTATHECMSWC

CTTNTFSLS+ GNNG WCT T EC C

CTTNTFSLSNALGNNGGWCTLTKECQPNC

36.7%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

FSLSDYWGNNGNWCTATHECMSWC

+++S GN G +CT T ECM C

YNISCRLGNKGAYCTLTVECMPSC

12.8%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

CTATHECMSWC

CT + EC C

CTLSKECQPNC

CQS04_RS09625

Leader:

MHNKSIHENSEKELELGRYLESDMLALTDDEVAGG

Core:

ATPTIVITAITGYISANSCPTTACTRAC

Core with dehydrations:

ADhbPDhbIVIDhbAIDhbGYIDhaANDhaCysPDhbDhbACysDhbRACys

antiSMASH-DB 4.0 matches for CQS04_RS09625

100.0%

NZ_PCGR01000003.1and 1 other:

NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09625_lanthipeptide

Lanthipeptides: CQS04_RS09625_lanthipeptide

ATPTIVITAITGYISANSCPTTACTRAC

82.1%

NZ_CP061868.1and 1 other:

NZ_CP061868.1 Lanthipeptides: IE339_RS06335_lanthipeptide

Lanthipeptides: IE339_RS06335_lanthipeptide

TPTIVITAITGYISANSCPTTACTRAC

TPTIVITA+TGYIS N+CPTT+CTRAC

TPTIVITAVTGYISTNTCPTTSCTRAC

63.3%

NZ_NUIO01000031.1and 1 other:

NZ_NUIO01000031.1 Lanthipeptides: CN977_RS23165_lanthipeptide

Lanthipeptides: CN977_RS23165_lanthipeptide

TPTIVITAITGYISANSCPTTACTRAC

T +I +TA++GYIS+N+CPTTACTRAC

TVSIALTAVSGYISSNTCPTTACTRAC

with 101 more sequence matches

Only the first 10 are displayed here.

60.7%

NZ_CP016767.1and 3 others:

NZ_CP016767.1 Lanthipeptides: BCV50_RS13415_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptide

Lanthipeptides: BCV50_RS13415_lanthipeptide

ITAITGYISANSCPTTACTRAC

++ ITGYIS+N+CPTTACTRAC

LSVITGYISSNTCPTTACTRAC

60.7%

NZ_CP034414.1and 1 other:

NZ_CP034414.1 Lanthipeptides: EI692_RS18435_lanthipeptide

Lanthipeptides: EI692_RS18435_lanthipeptide

TPTIVITAITGYISANSCPTTACTRAC

TP I I ++G+IS N+CP+TACTRAC

TPAISI-LVSGFISTNTCPSTACTRAC

59.4%

NZ_CACZYW010000004.1and 3 others:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide

Lanthipeptides: HUF10_RS02820_lanthipeptide

ATP-TIVITAITGYISANSCPTTACTRAC

ATP T VI A++ Y+S +CPTTACTRAC

ATPATPVIVAVSAYVSDKTCPTTACTRAC

57.6%

NZ_LR134317.1and 1 other:

NZ_LR134317.1 Lanthipeptides: EL136_RS01690_lanthipeptide

Lanthipeptides: EL136_RS01690_lanthipeptide

ATPTIVI--TAITGYISANSCPTTACTRAC

ATP +V A+T +ISAN+CPTT+CTRAC

ATPWLVKASVAVTAFISANTCPTTSCTRAC

57.6%

NZ_MIFN01000022.1and 1 other:

NZ_MIFN01000022.1 Lanthipeptides: BHL26_RS15355_lanthipeptide

Lanthipeptides: BHL26_RS15355_lanthipeptide

TPTIV-----ITAITGYISANSCPTTACTRAC

TPT++ +TA++GYIS+N+CP+TACTRAC

TPTVLATTGALTAVSGYISSNTCPSTACTRAC

57.1%

NZ_KE384533.1and 2 others:

NZ_KE384533.1 Lanthipeptides: K329_RS31315_lanthipeptideNZ_KE384533.1 Lanthipeptides: K329_RS31315_lanthipeptide

Lanthipeptides: K329_RS31315_lanthipeptide

TPTIVITAITGYISANSCPTTACTRAC

TPTIVI+ ++ Y+S N+CPTT+CT C

TPTIVISVVSAYVSTNTCPTTSCTDEC

54.8%

NZ_AP026714.1and 21 others:

NZ_AP026714.1 Lanthipeptides: PO853_RS06520_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11270_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11270_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03990_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03990_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09815_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09815_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00090_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00090_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07695_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07695_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03740_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03740_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00125_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00125_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07745_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07745_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04680_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04680_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07985_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07985_lanthipeptide

Lanthipeptides: PO853_RS06520_lanthipeptide

ATPTIVI---TAITGYISANSCPTTACTRAC

TPTI I A++G+IS +CPT+ CTRAC

GTPTITIPISIAVSGWISDKTCPTSVCTRAC

53.6%

NZ_CP051884.1and 3 others:

NZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptide

Lanthipeptides: HGK68_RS15130_lanthipeptide

ATPTIVITAITGYISANSCPTTACTRAC

TPT+V++ ++ +IS N+CP++ACTRAC

GTPTVVLSIVSAWISNNTCPSSACTRAC

53.6%

NZ_JALAPU010000003.1and 7 others:

NZ_JALAPU010000003.1 Lanthipeptides: MOD17_RS07925_lanthipeptideNZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00585_lanthipeptideNZ_JALATU010000001.1 Lanthipeptides: MOE27_RS00585_lanthipeptideNZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17010_lanthipeptideNZ_JALAUG010000006.1 Lanthipeptides: MOE44_RS17010_lanthipeptideNZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04640_lanthipeptideNZ_JALAVR010000001.1 Lanthipeptides: MOE47_RS04640_lanthipeptide

Lanthipeptides: MOD17_RS07925_lanthipeptide

ITAITGYISANSCPTTACTRAC

++ +T YIS+N+CPTTACTRAC

LSVVTAYISSNTCPTTACTRAC

53.3%

NZ_QGEE01000020.1and 3 others:

NZ_QGEE01000020.1 Lanthipeptides: DKP74_RS06165_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05385_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05385_lanthipeptide

Lanthipeptides: DKP74_RS06165_lanthipeptide

TPTIVITAI--TGYISANSCPTTACTRAC

TP I +A+ +G++S+++CPTTACTRAC

TPVIGYSAVIVSGFVSSHTCPTTACTRAC

MIBiG 4.0 matches for CQS04_RS09625

25.0%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

CPTTACTRAC

CPTT CT C

CPTTKCTSKC

24.3%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

ISANSCPTTACTRAC

+SA CPTT CT C

VSAAFCPTTKCTSRC

Lanthipeptide(s) for CQS04_RS09640

CQS04_RS09620

Leader:

MKNELLKQEQVTWFEEVADQQFDDDVFGA

Core:

CTTNTFSLSDYWGNNGNWCTATHECMSWCK

Core with dehydrations:

CysDhbDhbNDhbFDhaLDhaDYWGNNGNWCysDhbADhbHECysMDhaWCysK

antiSMASH-DB 4.0 matches for CQS04_RS09620

100.0%

NZ_PCGR01000003.1and 1 other:

NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09620_lanthipeptide

Lanthipeptides: CQS04_RS09620_lanthipeptide

CTTNTFSLSDYWGNNGNWCTATHECMSWCK

93.3%

NZ_AP026714.1and 21 others:

Lanthipeptides: PO853_RS06515_lanthipeptide

CTTNTFSLSDYWGNNGNWCTATHECMSWCK

CTTNTFSLSDYWGN GNWCTATHECM WCK

CTTNTFSLSDYWGNKGNWCTATHECMGWCK

93.3%

NZ_CP061868.1and 1 other:

NZ_CP061868.1 Lanthipeptides: IE339_RS06330_lanthipeptide

Lanthipeptides: IE339_RS06330_lanthipeptide

CTTNTFSLSDYWGNNGNWCTATHECMSWCK

CTTNTFSLSDYWGN G WCTATHECMSWCK

CTTNTFSLSDYWGNKGGWCTATHECMSWCK

with 104 more sequence matches

Only the first 10 are displayed here.

93.3%

NZ_FMPI01000012.1and 1 other:

NZ_FMPI01000012.1 Lanthipeptides: BJR39_RS08305_lanthipeptide

Lanthipeptides: BJR39_RS08305_lanthipeptide

CTTNTFSLSDYWGNNGNWCTATHECMSWCK

C+TNTFSLSDYWGNNGNWCTA+HECMSWCK

CSTNTFSLSDYWGNNGNWCTASHECMSWCK

90.0%

NZ_BLIS01000009.1and 7 others:

Lanthipeptides: GVO03_RS04820_lanthipeptide

CTTNTFSLSDYWGNNGNWCTATHECMSWCK

CTTNTFSLSDYWGN GNWCT THECM+WCK

CTTNTFSLSDYWGNKGNWCTLTHECMNWCK

90.0%

NZ_NUIO01000031.1and 1 other:

NZ_NUIO01000031.1 Lanthipeptides: CN977_RS23160_lanthipeptide

Lanthipeptides: CN977_RS23160_lanthipeptide

CTTNTFSLSDYWGNNGNWCTATHECMSWCK

CTTNTFSLSDYWGN+G+WCTATHEC+SWCK

CTTNTFSLSDYWGNDGSWCTATHECLSWCK

86.7%

NZ_CACZYW010000004.1and 1 other:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02825_lanthipeptide

Lanthipeptides: HUF10_RS02825_lanthipeptide

CTTNTFSLSDYWGNNGNWCTATHECMSWCK

C+TNTFSLSDYWGNNGNWCT +HECM+WCK

CSTNTFSLSDYWGNNGNWCTLSHECMAWCK

86.7%

NZ_CP027862.1and 1 other:

NZ_CP027862.1 Lanthipeptides: allorf_0097945_0098112_lanthipeptide

Lanthipeptides: allorf_0097945_0098112_lanthipeptide

CTTNTFSLSDYWGNNGNWCTATHECMSWCK

C+TNTFSLSDYWGN G WCT THECMSWCK

CSTNTFSLSDYWGNRGYWCTLTHECMSWCK

86.7%

NZ_CP051884.1and 2 others:

NZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptide

Lanthipeptides: HGK68_RS15125_lanthipeptide

CTTNTFSLSDYWGNNGNWCTATHECMSWCK

C+TNTFSLSDYWGNNG CT THECMSWCK

CSTNTFSLSDYWGNNGWLCTITHECMSWCK

83.3%

NZ_CP034414.1and 1 other:

NZ_CP034414.1 Lanthipeptides: EI692_RS18440_lanthipeptide

Lanthipeptides: EI692_RS18440_lanthipeptide

CTTNTFSLSDYWGNNGNWCTATHECMSWCK

C+TNTFSLSDYWGN G WCT +HECMSWCK

CSTNTFSLSDYWGNKGGWCTISHECMSWCK

83.3%

NZ_FNHR01000005.1and 1 other:

NZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05590_lanthipeptide

Lanthipeptides: BLQ37_RS05590_lanthipeptide

CTTNTFSLSDYWGNNGNWCTATHECMSWCK

C+TNTFSLSDY GNNGNWCT +HECM+WCK

CSTNTFSLSDYMGNNGNWCTISHECMAWCK

83.3%

NZ_MIFN01000022.1and 1 other:

NZ_MIFN01000022.1 Lanthipeptides: BHL26_RS15350_lanthipeptide

Lanthipeptides: BHL26_RS15350_lanthipeptide

CTTNTFSLSDYWGNNGNWCTATHECMSWCK

CTTNTFSLSDYWGN+G+WC+ +HECMSWCK

CTTNTFSLSDYWGNDGSWCSLSHECMSWCK

83.3%

NZ_QGEE01000020.1and 5 others:

Lanthipeptides: DKP74_RS06160_lanthipeptide

CTTNTFSLSDYWGNNGNWCTATHECMSWCK

C+TNTFSLSDYWGN GNWCT +HECM+WCK

CSTNTFSLSDYWGNRGNWCTLSHECMAWCK

MIBiG 4.0 matches for CQS04_RS09620

66.7%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

CTTNTFSLSDYWGNNGNWCTATHECMSWC

CTTNTFSLS+ GNNG WCT T EC C

CTTNTFSLSNALGNNGGWCTLTKECQPNC

36.7%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

FSLSDYWGNNGNWCTATHECMSWC

+++S GN G +CT T ECM C

YNISCRLGNKGAYCTLTVECMPSC

12.8%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

CTATHECMSWC

CT + EC C

CTLSKECQPNC

CQS04_RS09625

Leader:

MHNKSIHENSEKELELGRYLESDMLALTDDEVAGG

Core:

ATPTIVITAITGYISANSCPTTACTRAC

Core with dehydrations:

ADhbPDhbIVIDhbAIDhbGYIDhaANDhaCysPDhbDhbACysDhbRACys

antiSMASH-DB 4.0 matches for CQS04_RS09625

100.0%

NZ_PCGR01000003.1and 1 other:

NZ_PCGR01000003.1 Lanthipeptides: CQS04_RS09625_lanthipeptide

Lanthipeptides: CQS04_RS09625_lanthipeptide

ATPTIVITAITGYISANSCPTTACTRAC

82.1%

NZ_CP061868.1and 1 other:

NZ_CP061868.1 Lanthipeptides: IE339_RS06335_lanthipeptide

Lanthipeptides: IE339_RS06335_lanthipeptide

TPTIVITAITGYISANSCPTTACTRAC

TPTIVITA+TGYIS N+CPTT+CTRAC

TPTIVITAVTGYISTNTCPTTSCTRAC

63.3%

NZ_NUIO01000031.1and 1 other:

NZ_NUIO01000031.1 Lanthipeptides: CN977_RS23165_lanthipeptide

Lanthipeptides: CN977_RS23165_lanthipeptide

TPTIVITAITGYISANSCPTTACTRAC

T +I +TA++GYIS+N+CPTTACTRAC

TVSIALTAVSGYISSNTCPTTACTRAC

with 101 more sequence matches

Only the first 10 are displayed here.

60.7%

NZ_CP016767.1and 3 others:

NZ_CP016767.1 Lanthipeptides: BCV50_RS13415_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptideNZ_JALAMZ010000009.1 Lanthipeptides: MOC43_RS15330_lanthipeptide

Lanthipeptides: BCV50_RS13415_lanthipeptide

ITAITGYISANSCPTTACTRAC

++ ITGYIS+N+CPTTACTRAC

LSVITGYISSNTCPTTACTRAC

60.7%

NZ_CP034414.1and 1 other:

NZ_CP034414.1 Lanthipeptides: EI692_RS18435_lanthipeptide

Lanthipeptides: EI692_RS18435_lanthipeptide

TPTIVITAITGYISANSCPTTACTRAC

TP I I ++G+IS N+CP+TACTRAC

TPAISI-LVSGFISTNTCPSTACTRAC

59.4%

NZ_CACZYW010000004.1and 3 others:

NZ_CACZYW010000004.1 Lanthipeptides: HUF10_RS02820_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptideNZ_FNHR01000005.1 Lanthipeptides: BLQ37_RS05585_lanthipeptide

Lanthipeptides: HUF10_RS02820_lanthipeptide

ATP-TIVITAITGYISANSCPTTACTRAC

ATP T VI A++ Y+S +CPTTACTRAC

ATPATPVIVAVSAYVSDKTCPTTACTRAC

57.6%

NZ_LR134317.1and 1 other:

NZ_LR134317.1 Lanthipeptides: EL136_RS01690_lanthipeptide

Lanthipeptides: EL136_RS01690_lanthipeptide

ATPTIVI--TAITGYISANSCPTTACTRAC

ATP +V A+T +ISAN+CPTT+CTRAC

ATPWLVKASVAVTAFISANTCPTTSCTRAC

57.6%

NZ_MIFN01000022.1and 1 other:

NZ_MIFN01000022.1 Lanthipeptides: BHL26_RS15355_lanthipeptide

Lanthipeptides: BHL26_RS15355_lanthipeptide

TPTIV-----ITAITGYISANSCPTTACTRAC

TPT++ +TA++GYIS+N+CP+TACTRAC

TPTVLATTGALTAVSGYISSNTCPSTACTRAC

57.1%

NZ_KE384533.1and 2 others:

NZ_KE384533.1 Lanthipeptides: K329_RS31315_lanthipeptideNZ_KE384533.1 Lanthipeptides: K329_RS31315_lanthipeptide

Lanthipeptides: K329_RS31315_lanthipeptide

TPTIVITAITGYISANSCPTTACTRAC

TPTIVI+ ++ Y+S N+CPTT+CT C

TPTIVISVVSAYVSTNTCPTTSCTDEC

54.8%

NZ_AP026714.1and 21 others:

Lanthipeptides: PO853_RS06520_lanthipeptide

ATPTIVI---TAITGYISANSCPTTACTRAC

TPTI I A++G+IS +CPT+ CTRAC

GTPTITIPISIAVSGWISDKTCPTSVCTRAC

53.6%

NZ_CP051884.1and 3 others:

NZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15130_lanthipeptide

Lanthipeptides: HGK68_RS15130_lanthipeptide

ATPTIVITAITGYISANSCPTTACTRAC

TPT+V++ ++ +IS N+CP++ACTRAC

GTPTVVLSIVSAWISNNTCPSSACTRAC

53.6%

NZ_JALAPU010000003.1and 7 others:

Lanthipeptides: MOD17_RS07925_lanthipeptide

ITAITGYISANSCPTTACTRAC

++ +T YIS+N+CPTTACTRAC

LSVVTAYISSNTCPTTACTRAC

53.3%

NZ_QGEE01000020.1and 3 others:

NZ_QGEE01000020.1 Lanthipeptides: DKP74_RS06165_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05385_lanthipeptideNZ_RPFX01000021.1 Lanthipeptides: EHF19_RS05385_lanthipeptide

Lanthipeptides: DKP74_RS06165_lanthipeptide

TPTIVITAI--TGYISANSCPTTACTRAC

TP I +A+ +G++S+++CPTTACTRAC

TPVIGYSAVIVSGFVSSHTCPTTACTRAC

MIBiG 4.0 matches for CQS04_RS09625

25.0%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

CPTTACTRAC

CPTT CT C

CPTTKCTSKC

24.3%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

ISANSCPTTACTRAC

+SA CPTT CT C

VSAAFCPTTKCTSRC

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.93 out of 27.78

Confidence: medium

Additional weak hits (6):

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.13 out of 20.01

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.78 out of 26.12

Confidence: weak

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.94 out of 19.52

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.98 out of 31.73

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.81 out of 31.73

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.00 out of 30.98

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

CQS04_RS09620 - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 3315.4 Da

Molecular weight: 3317.6 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3335.6 Da N = 1; 3353.7 Da N = 2; 3371.7 Da N = 3; 3389.7 Da N = 4

CQS04_RS09625 - Class II

Cleavage pHMM score: 0.60

RODEO score: 0

Monoisotopic mass: 2637.4 Da

Molecular weight: 2639.0 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2657.1 Da N = 1; 2675.1 Da N = 2; 2693.1 Da N = 3; 2711.1 Da N = 4; 2729.1 Da N = 5; 2747.2 Da N = 6

CQS04_RS09620 - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 3315.4 Da

Molecular weight: 3317.6 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3335.6 Da N = 1; 3353.7 Da N = 2; 3371.7 Da N = 3; 3389.7 Da N = 4

CQS04_RS09625 - Class II

Cleavage pHMM score: 0.60

RODEO score: 0

Monoisotopic mass: 2637.4 Da

Molecular weight: 2639.0 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2657.1 Da N = 1; 2675.1 Da N = 2; 2693.1 Da N = 3; 2711.1 Da N = 4; 2729.1 Da N = 5; 2747.2 Da N = 6

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ToxT	Regulator of MSHA biosynthesis

NZ_PCGR01000003.1 - Region 2 - terpene

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Location: 271,934 - 292,767 nt. (total: 20,834 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

CQS04_RS10405: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

CQS04_RS10410: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

CQS04_RS10435: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

Transferases: acyltransferase

CQS04_RS10425: acyltransferase

smcogs: SMCOG1141: acyltransferase

Lyases: dehydratase

CQS04_RS10395: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000645.3	0.70	terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0000647.3	0.69	terpene	carotenoid	Rhodobacter sphaeroides
BGC0000646.5	0.47	terpene	β-carotein	uncultured bacterium
BGC0000648.3	0.44	terpene	carotenoid	Myxococcus xanthus
BGC0000664.5	0.42	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001227.3	0.41	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000633.3	0.41	terpene	carotenoid	Streptomyces avermitilis
BGC0001456.3	0.40	terpene	isorenieratene	Streptomyces argillaceus
BGC0000643.3	0.40	terpene	carotenoid	Brevundimonas vesicularis
BGC0000640.3	0.40	terpene	carotenoid	Enterobacteriaceae bacterium DC404

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000645.3	0.70	terpene	carotenoid	Halobacillus halophilus DSM 2266
BGC0000647.3	0.69	terpene	carotenoid	Rhodobacter sphaeroides
BGC0000646.5	0.47	terpene	β-carotein	uncultured bacterium
BGC0000648.3	0.44	terpene	carotenoid	Myxococcus xanthus
BGC0000664.5	0.42	terpene	isorenieratene	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001227.3	0.41	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000633.3	0.41	terpene	carotenoid	Streptomyces avermitilis
BGC0001456.3	0.40	terpene	isorenieratene	Streptomyces argillaceus
BGC0000643.3	0.40	terpene	carotenoid	Brevundimonas vesicularis
BGC0000640.3	0.40	terpene	carotenoid	Enterobacteriaceae bacterium DC404

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	C30 carotenoid	diapophytoene	C30	acyclic	none

Genes with terpene domains:

CQS04_RS10415: PT_phytoene_like

Domain 1 (4 - 276): Prenyltransferase; Phytoene synthase like

Subtype: Diapophytoene synthase

Reactions:: FPP → diapophytoene

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.87 out of 23.79

Confidence: strong

Additional weak hits (1):

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 20.38 out of 27.18

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
FPP	Farnesyl diphosphate

TFBS definitions

Regulator	Description
IolR	Regulator of the inositol catabolism