GCF_002583065.1 - 10 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_NUOG01000008.1 (Bacillus sp. AFS033286)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 2.1	azole-containing-RiPP	115,391	138,898

NZ_NUOG01000010.1 (Bacillus sp. AFS033286)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 4.1	NI-siderophore	51,562	83,276	High	petrobactin	other:other

NZ_NUOG01000013.1 (Bacillus sp. AFS033286)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 16.1	betalactone	1	23,483	Low	fengycin	NRPS:Type I
Region 16.2	RiPP-like	220,833	231,099

NZ_NUOG01000014.1 (Bacillus sp. AFS033286)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 17.1	terpene	61,976	83,829	Low	molybdenum cofactor	other:other

NZ_NUOG01000083.1 (Bacillus sp. AFS033286)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 31.1	lanthipeptide-class-i	4,243	30,729	Low	penisin	ribosomal:RiPP

NZ_NUOG01000025.1 (Bacillus sp. AFS033286)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 33.1	terpene-precursor	487,407	508,297

NZ_NUOG01000086.1 (Bacillus sp. AFS033286)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 35.1	lassopeptide	25,018	43,921	High	paeninodin	ribosomal:unmodified

NZ_NUOG01000004.1 (Bacillus sp. AFS033286)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 64.1	RiPP-like	38,341	48,652

NZ_NUOG01000005.1 (Bacillus sp. AFS033286)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 66.1	lassopeptide,RiPP-like	3,849	30,385

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 2.1	azole-containing-RiPP	115,391	138,898
Region 4.1	NI-siderophore	51,562	83,276	High	petrobactin	other:other
Region 16.1	betalactone	1	23,483	Low	fengycin	NRPS:Type I
Region 16.2	RiPP-like	220,833	231,099
Region 17.1	terpene	61,976	83,829	Low	molybdenum cofactor	other:other
Region 31.1	lanthipeptide-class-i	4,243	30,729	Low	penisin	ribosomal:RiPP
Region 33.1	terpene-precursor	487,407	508,297
Region 35.1	lassopeptide	25,018	43,921	High	paeninodin	ribosomal:unmodified
Region 64.1	RiPP-like	38,341	48,652
Region 66.1	lassopeptide,RiPP-like	3,849	30,385

No secondary metabolite regions were found in these records:: NZ_NUOG01000007.1 (Bacillus sp. AFS033286); NZ_NUOG01000009.1 (Bacillus sp. AFS033286); NZ_NUOG01000011.1 (Bacillus sp. AFS033286); NZ_NUOG01000012.1 (Bacillus sp. AFS033286); NZ_NUOG01000015.1 (Bacillus sp. AFS033286); NZ_NUOG01000016.1 (Bacillus sp. AFS033286); NZ_NUOG01000017.1 (Bacillus sp. AFS033286); NZ_NUOG01000018.1 (Bacillus sp. AFS033286); NZ_NUOG01000023.1 (Bacillus sp. AFS033286); NZ_NUOG01000019.1 (Bacillus sp. AFS033286); NZ_NUOG01000020.1 (Bacillus sp. AFS033286); NZ_NUOG01000021.1 (Bacillus sp. AFS033286); NZ_NUOG01000022.1 (Bacillus sp. AFS033286); NZ_NUOG01000026.1 (Bacillus sp. AFS033286); NZ_NUOG01000027.1 (Bacillus sp. AFS033286); NZ_NUOG01000028.1 (Bacillus sp. AFS033286); NZ_NUOG01000029.1 (Bacillus sp. AFS033286); NZ_NUOG01000024.1 (Bacillus sp. AFS033286); NZ_NUOG01000075.1 (Bacillus sp. AFS033286); NZ_NUOG01000076.1 (Bacillus sp. AFS033286); NZ_NUOG01000077.1 (Bacillus sp. AFS033286); NZ_NUOG01000078.1 (Bacillus sp. AFS033286); NZ_NUOG01000079.1 (Bacillus sp. AFS033286); NZ_NUOG01000080.1 (Bacillus sp. AFS033286); NZ_NUOG01000081.1 (Bacillus sp. AFS033286); NZ_NUOG01000082.1 (Bacillus sp. AFS033286); NZ_NUOG01000084.1 (Bacillus sp. AFS033286); NZ_NUOG01000085.1 (Bacillus sp. AFS033286); NZ_NUOG01000087.1 (Bacillus sp. AFS033286); NZ_NUOG01000088.1 (Bacillus sp. AFS033286); NZ_NUOG01000089.1 (Bacillus sp. AFS033286); NZ_NUOG01000090.1 (Bacillus sp. AFS033286); NZ_NUOG01000091.1 (Bacillus sp. AFS033286); NZ_NUOG01000092.1 (Bacillus sp. AFS033286); NZ_NUOG01000093.1 (Bacillus sp. AFS033286); NZ_NUOG01000094.1 (Bacillus sp. AFS033286); NZ_NUOG01000001.1 (Bacillus sp. AFS033286); NZ_NUOG01000030.1 (Bacillus sp. AFS033286); NZ_NUOG01000031.1 (Bacillus sp. AFS033286); NZ_NUOG01000032.1 (Bacillus sp. AFS033286); NZ_NUOG01000033.1 (Bacillus sp. AFS033286); NZ_NUOG01000034.1 (Bacillus sp. AFS033286); NZ_NUOG01000035.1 (Bacillus sp. AFS033286); NZ_NUOG01000036.1 (Bacillus sp. AFS033286); NZ_NUOG01000038.1 (Bacillus sp. AFS033286); NZ_NUOG01000039.1 (Bacillus sp. AFS033286); NZ_NUOG01000002.1 (Bacillus sp. AFS033286); NZ_NUOG01000042.1 (Bacillus sp. AFS033286); NZ_NUOG01000043.1 (Bacillus sp. AFS033286); NZ_NUOG01000044.1 (Bacillus sp. AFS033286); NZ_NUOG01000046.1 (Bacillus sp. AFS033286); NZ_NUOG01000047.1 (Bacillus sp. AFS033286); NZ_NUOG01000049.1 (Bacillus sp. AFS033286); NZ_NUOG01000003.1 (Bacillus sp. AFS033286); NZ_NUOG01000052.1 (Bacillus sp. AFS033286); NZ_NUOG01000058.1 (Bacillus sp. AFS033286); NZ_NUOG01000062.1 (Bacillus sp. AFS033286); NZ_NUOG01000006.1 (Bacillus sp. AFS033286)

Compact view

NZ_NUOG01000008.1 - Region 1 - azole-containing-RiPP

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Location: 115,391 - 138,898 nt. (total: 23,508 nt) Show pHMM detection rules used

azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Azole RiPPs

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidoreductase

COE07_RS03065: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Transferases: methyltransferase

COE07_RS03075: methyltransferase

smcogs: SMCOG1089: methyltransferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001174.4	0.44	ribosomal	corynazolicin	Corynebacterium urealyticum DSM 7111
BGC0002013.4	0.44	ribosomal	curacozole	Streptomyces curacoi
BGC0000607.5	0.43	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0001535.3	0.43	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001146.5	0.41	ribosomal	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0001173.5	0.41	ribosomal	plantazolicin	Bacillus pumilus ATCC 7061
BGC0000606.5	0.39	ribosomal	lactazole	Streptomyces lactacystinaeus
BGC0001860.4	0.39	ribosomal	thiomuracin	Thermobispora bispora DSM 43833
BGC0000613.5	0.38	ribosomal	thiomuracin A	Nonomuraea sp. Bp3714-39
BGC0000628.4	0.38	ribosomal	lactocillin	Lactobacillus paragasseri JV-V03

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001174.4	0.44	ribosomal	corynazolicin	Corynebacterium urealyticum DSM 7111
BGC0002013.4	0.44	ribosomal	curacozole	Streptomyces curacoi
BGC0000607.5	0.43	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0001535.3	0.43	other (other)	branched-chain fatty acids	Streptomyces filamentosus
BGC0001146.5	0.41	ribosomal	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0001173.5	0.41	ribosomal	plantazolicin	Bacillus pumilus ATCC 7061
BGC0000606.5	0.39	ribosomal	lactazole	Streptomyces lactacystinaeus
BGC0001860.4	0.39	ribosomal	thiomuracin	Thermobispora bispora DSM 43833
BGC0000613.5	0.38	ribosomal	thiomuracin A	Nonomuraea sp. Bp3714-39
BGC0000628.4	0.38	ribosomal	lactocillin	Lactobacillus paragasseri JV-V03

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.43 out of 32.93

Confidence: medium

Additional weak hits (1):

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.85 out of 29.38

Confidence: weak

(Thi)azol(in)e containing peptide predictions

No core peptides found.

RREFinder

TFBS Finder

Azole RiPPs

RRE predictions

: RRE type: Heterocycloanthracin_C_RRE; Location: 0 - 100; Score: 181.5; RRE type: Thiopeptide_F_RRE; Location: 9 - 89; Score: 39.9

TFBS definitions

Regulator	Description
LexA variant 3	Repressor of DNA damage response

Core peptide predictions

No core peptides found.

NZ_NUOG01000010.1 - Region 1 - NI-siderophore

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Location: 51,562 - 83,276 nt. (total: 31,715 nt) Show pHMM detection rules used

NI-siderophore: IucA_IucC

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: aminotransferase

COE07_RS05610: aminotransferase

smcogs: SMCOG1019: aminotransferase

Hydrolases: deacetylase

COE07_RS05495: polysaccharide deacetylase

smcogs: SMCOG1235: polysaccharide deacetylase

COE07_RS05545: polysaccharide deacetylase

smcogs: SMCOG1235: polysaccharide deacetylase

Ligases: ligase synthase

COE07_RS05520: cysteine synthase

smcogs: SMCOG1081: cysteine synthase

COE07_RS05575: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000942.4	0.88	other (other)	petrobactin	Bacillus anthracis str. Ames
BGC0000295.5	0.53	NRPS	acinetoferrin	Acinetobacter haemolyticus
BGC0001478.5	0.51	other (other)	desferrioxamine E	Streptomyces sp. ID38640
BGC0002692.2	0.50	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0002620.2	0.50	other (other)	fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4	Fulvivirga marina
BGC0002305.2	0.50	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0001531.5	0.50	other (other)	bisucaberin B	Tenacibaculum mesophilum
BGC0002633.2	0.48	other (other)	schizokinen	Leptolyngbya sp. PCC 7376
BGC0001498.5	0.48	other (other)	aerobactin	Xenorhabdus szentirmaii DSM 16338
BGC0002464.3	0.48	other (other)	alcaligin	Bordetella pertussis Tohama I

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000942.4	0.88	other (other)	petrobactin	Bacillus anthracis str. Ames
BGC0000295.5	0.53	NRPS	acinetoferrin	Acinetobacter haemolyticus
BGC0001478.5	0.51	other (other)	desferrioxamine E	Streptomyces sp. ID38640
BGC0002692.2	0.50	other (other)	speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B	Kribbella speibonae
BGC0002620.2	0.50	other (other)	fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4	Fulvivirga marina
BGC0002305.2	0.50	other (other)	legonoxamine A, desferrioxamine B, legonoxamine B	Streptomyces sp.
BGC0001531.5	0.50	other (other)	bisucaberin B	Tenacibaculum mesophilum
BGC0002633.2	0.48	other (other)	schizokinen	Leptolyngbya sp. PCC 7376
BGC0001498.5	0.48	other (other)	aerobactin	Xenorhabdus szentirmaii DSM 16338
BGC0002464.3	0.48	other (other)	alcaligin	Bordetella pertussis Tohama I

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.61 out of 29.38

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57

Confidence: strong

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.55 out of 19.26

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.72 out of 29.38

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.18 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.18 out of 28.19

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.85 out of 28.19

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 15.13 out of 18.16

Confidence: strong

Additional weak hits (7):

AfsQ1

Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.58 out of 19.52

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.23 out of 30.11

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.92 out of 30.11

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.12 out of 29.38

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.91 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.84 out of 32.74

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.60 out of 36.54

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CRP	Cyclic AMP receptor protein
FuR variant 1	Ferric Uptake Regulator
ToxT	Regulator of MSHA biosynthesis
ZuR variant 1	Zinc-responsive repressor

NZ_NUOG01000013.1 - Region 1 - betalactone

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Location: 1 - 23,483 nt. (total: 23,483 nt) Show pHMM detection rules used

Region on contig edge.

betalactone: (HMGL-like and AMP-binding)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

COE07_RS08290: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Transferases: acetyltransferase carboxylase methyltransferase transferase

COE07_RS08295: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

COE07_RS08315: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

COE07_RS08340: GCN5-related N-acetyltransferase

smcogs: SMCOG1111: GCN5-related N-acetyltransferase

COE07_RS08380: methyltransferase

smcogs: SMCOG1248: methyltransferase

Lyases: hydratase

COE07_RS08310: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase

COE07_RS08305: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

COE07_RS08320: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002284.3	0.55	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000131.5	0.46	PKS	pyrrolomycin	Streptomyces sp. UC 11065
BGC0000706.3	0.46	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0000234.5	0.43	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000623.3	0.42	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001226.4	0.42	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0000563.4	0.42	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0001103.5	0.42	NRPS, PKS	mycosubtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0002700.2	0.41	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0001095.5	0.41	NRPS	fengycin	Bacillus velezensis FZB42

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002284.3	0.55	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000131.5	0.46	PKS	pyrrolomycin	Streptomyces sp. UC 11065
BGC0000706.3	0.46	saccharide	kanamycin	Streptomyces kanamyceticus
BGC0000234.5	0.43	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000623.3	0.42	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001226.4	0.42	ribosomal	streptocollin	Streptomyces collinus Tu 365
BGC0000563.4	0.42	ribosomal	venezuelin	Streptomyces venezuelae ATCC 10712
BGC0001103.5	0.42	NRPS, PKS	mycosubtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0002700.2	0.41	ribosomal	bacinapeptin	Bacillus nakamurai
BGC0001095.5	0.41	NRPS	fengycin	Bacillus velezensis FZB42

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.52 out of 25.88

Confidence: medium

VqsM

Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.42 out of 20.47

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.94 out of 25.31

Confidence: medium

CatR

Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.67 out of 25.31

Confidence: medium

Additional weak hits (2):

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.13 out of 25.88

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 25.44 out of 36.53

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CatR	H2O2-responsive repressor
PsrA	Oleic acid responsive regulator
VqsM	Regulator of quorum-sensing signalling systems

NZ_NUOG01000013.1 - Region 2 - RiPP-like

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Location: 220,833 - 231,099 nt. (total: 10,267 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: aminotransferase

COE07_RS09595: aminotransferase

smcogs: SMCOG1019: aminotransferase

Hydrolases: hydrolase

COE07_RS09565: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001994.4	0.40	other (other)	β-ethynylserine	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0001488.3	0.36	other (other)	4-formylaminooxyvinylglycine	Pseudomonas fluorescens WH6
BGC0001964.2	0.28	PKS	alkylpyrone-407, alkylpyrone-393	Cystobacterineae bacterium
BGC0002536.3	0.28	NRPS	alazopeptin	Kitasatospora azatica KCTC 9699
BGC0000721.4	0.26	saccharide	tobramycin	Streptoalloteichus tenebrarius
BGC0000381.5	0.26	NRPS	lichenysin	Bacillus licheniformis DSM 13 = ATCC 14580
BGC0002440.3	0.24	NRPS	longicatenamide B, longicatenamide C, longicatenamide A, longicatenamide D	Streptomyces sp.
BGC0000388.5	0.24	NRPS	mannopeptimycin	Streptomyces hygroscopicus
BGC0001814.5	0.23	NRPS	ulleungmycin	Streptomyces sp. KCB13F003
BGC0001406.5	0.22	NRPS	telomycin	Streptomyces canus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001994.4	0.40	other (other)	β-ethynylserine	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0001488.3	0.36	other (other)	4-formylaminooxyvinylglycine	Pseudomonas fluorescens WH6
BGC0001964.2	0.28	PKS	alkylpyrone-407, alkylpyrone-393	Cystobacterineae bacterium
BGC0002536.3	0.28	NRPS	alazopeptin	Kitasatospora azatica KCTC 9699
BGC0000721.4	0.26	saccharide	tobramycin	Streptoalloteichus tenebrarius
BGC0000381.5	0.26	NRPS	lichenysin	Bacillus licheniformis DSM 13 = ATCC 14580
BGC0002440.3	0.24	NRPS	longicatenamide B, longicatenamide C, longicatenamide A, longicatenamide D	Streptomyces sp.
BGC0000388.5	0.24	NRPS	mannopeptimycin	Streptomyces hygroscopicus
BGC0001814.5	0.23	NRPS	ulleungmycin	Streptomyces sp. KCB13F003
BGC0001406.5	0.22	NRPS	telomycin	Streptomyces canus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.51 out of 20.97

Confidence: medium

Additional weak hits (2):

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.04 out of 25.88

Confidence: weak

NuR

Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.00 out of 30.98

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A

NZ_NUOG01000014.1 - Region 1 - terpene

Download region GenBank file

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Location: 61,976 - 83,829 nt. (total: 21,854 nt) Show pHMM detection rules used

terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

COE07_RS10635: aldehyde dehydrogenase

smcogs: SMCOG1017: aldehyde dehydrogenase

COE07_RS10640: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Lyases: lyase

COE07_RS10610: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000917.3	0.52	other (other)	molybdenum cofactor	Rhodobacter capsulatus
BGC0000888.5	0.49	other (other)	bacilysin	Bacillus sp. CS93
BGC0000866.5	0.46	other (other)	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0001928.2	0.46	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000916.5	0.46	other (other)	molybdenum cofactor	Staphylococcus carnosus
BGC0000812.3	0.45	other (other)	huperzine A	Shiraia sp. slf14
BGC0000231.5	0.42	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001605.3	0.42	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001197.5	0.42	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000234.5	0.41	PKS	jadomycin	Streptomyces venezuelae ATCC 10712

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000917.3	0.52	other (other)	molybdenum cofactor	Rhodobacter capsulatus
BGC0000888.5	0.49	other (other)	bacilysin	Bacillus sp. CS93
BGC0000866.5	0.46	other (other)	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0001928.2	0.46	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000916.5	0.46	other (other)	molybdenum cofactor	Staphylococcus carnosus
BGC0000812.3	0.45	other (other)	huperzine A	Shiraia sp. slf14
BGC0000231.5	0.42	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001605.3	0.42	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001197.5	0.42	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000234.5	0.41	PKS	jadomycin	Streptomyces venezuelae ATCC 10712

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
triterpene	hopanoid		C30	hopanoid skeleton	unknown
triterpene	polypodane		C30	polypodane skeleton	unknown

Genes with terpene domains:

COE07_RS10650: T2TS

Domain 1 (4 - 614): Type 2 terpene synthase

Subtype: Squalene substrate

Reactions:: squalene → hopanoid; squalene → polypodane

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (1):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 20.85 out of 30.22

Confidence: weak

Terpene

TFBS Finder

Glossary

No acronyms to display

TFBS definitions

Regulator	Description

NZ_NUOG01000083.1 - Region 1 - lanthipeptide-class-i

Download region GenBank file

Download region SVG

Location: 4,243 - 30,729 nt. (total: 26,487 nt) Show pHMM detection rules used

lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase dehydratase

COE07_RS24890: Lanthionine synthetase C family protein

smcogs: SMCOG1140: Lanthionine synthetase C family protein

COE07_RS24900: Lantibiotic dehydratase domain protein

smcogs: SMCOG1155: Lantibiotic dehydratase domain protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002576.2	0.76	ribosomal	mechercharmycin	Thermoactinomyces sp.
BGC0001289.5	0.61	ribosomal	penisin	Paenibacillus ehimensis
BGC0000542.3	0.57	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000541.5	0.57	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000538.3	0.56	ribosomal	nisin Z	Lactococcus lactis
BGC0001210.5	0.55	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000560.5	0.52	ribosomal	subtilomycin	Bacillus subtilis
BGC0001727.3	0.52	ribosomal	paenilan	Paenibacillus polymyxa E681
BGC0000515.4	0.52	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0000506.4	0.49	ribosomal	entianin	Bacillus subtilis subsp. spizizenii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002576.2	0.76	ribosomal	mechercharmycin	Thermoactinomyces sp.
BGC0001289.5	0.61	ribosomal	penisin	Paenibacillus ehimensis
BGC0000542.3	0.57	ribosomal	paenicidin B	Paenibacillus terrae
BGC0000541.5	0.57	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0000538.3	0.56	ribosomal	nisin Z	Lactococcus lactis
BGC0001210.5	0.55	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000560.5	0.52	ribosomal	subtilomycin	Bacillus subtilis
BGC0001727.3	0.52	ribosomal	paenilan	Paenibacillus polymyxa E681
BGC0000515.4	0.52	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0000506.4	0.49	ribosomal	entianin	Bacillus subtilis subsp. spizizenii

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for COE07_RS24900

COE07_RS24905

Leader:

MENNKLFDLDVQVSSNLEEQGGVEPR

Core:

SGIICTPGTCQTLCRITENWCSLKCS

Core with dehydrations:

DhaGIICysDhbPGDhbCysQDhbLCysRIDhbENWCysDhaLKCysDha

antiSMASH-DB 4.0 matches for COE07_RS24905

100.0%

NZ_NBBB01000022.1and 1 other:

NZ_NUOG01000083.1 Lanthipeptides: COE07_RS24905_lanthipeptide

Lanthipeptides: B6F67_RS25205_lanthipeptide

1

SGIICTPGTCQTLCRITENWCSLKCS

26

SGIICTPGTCQTLCRITENWCSLKCS

1

SGIICTPGTCQTLCRITENWCSLKCS

26

38.5%

NZ_JAIFIS010000001.1:

Lanthipeptides: K1X09_RS26315_lanthipeptide

1

SGIICTPG--TCQTLCRITENWC

21

SG+ICTP T C+I+ ++C

1

SGLICTPSCLTGTLNCKISLSFC

23

38.5%

NZ_JAKVDC010000001.1:

Lanthipeptides: MKN04_RS02755_lanthipeptide

1

SGIICTP--GTCQTLCRITENWC

21

SGIICTP T C+++ ++C

1

SGIICTPSCATGTLNCQVSLSFC

23

with 27 more sequence matches

Only the first 10 are displayed here.

38.5%

NZ_WTWY01000020.1:

Lanthipeptides: GQY55_RS27090_lanthipeptide

1

SGIICTPG--TCQTLCRITENWC

21

SG ICTP T C+I+ ++C

1

SGFICTPSCLTGTLNCKISLSFC

23

37.5%

NZ_NGMO01000003.1and 3 others:

NZ_NGMO01000003.1 Lanthipeptides: allorf_391705_391890_lanthipeptideNZ_NGMO01000003.1 Lanthipeptides: allorf_392307_392492_lanthipeptideNZ_NGMO01000003.1 Lanthipeptides: allorf_391705_391890_lanthipeptide

Lanthipeptides: allorf_392307_392492_lanthipeptide

3

IICTPGTCQTLCRITENWCSLKC

25

I CTPGTC + C T CS C

1

IACTPGTCNSNCPQTNWLCSNVC

23

36.1%

NZ_CP081833.1and 1 other:

NZ_CP097053.1 Lanthipeptides: allorf_0094918_0095106_lanthipeptide

Lanthipeptides: allorf_0004055_0004243_lanthipeptide

1

SGIICTPGTCQTLCRITENWCSLKC

25

S I CTPGTC C T CS C

3

SVIACTPGTCNNKCPNTNWLCSNVC

27

34.6%

NC_014483.2and 17 others:

NC_014622.2 Lanthipeptides: PPSC2_RS36205_lanthipeptideNC_017542.1 Lanthipeptides: PPM_RS07465_lanthipeptideNZ_CP006872.1 Lanthipeptides: PPSQR21_RS07740_lanthipeptideNZ_CP023711.1 Lanthipeptides: CPY53_RS22235_lanthipeptideNZ_CP025957.1 Lanthipeptides: C1A50_RS07530_lanthipeptideNZ_CP029370.1 Lanthipeptides: DI243_RS07495_lanthipeptideNZ_CP040829.1 Lanthipeptides: FGY93_RS00500_lanthipeptideNZ_CP049598.1 Lanthipeptides: G7L40_RS00115_lanthipeptideNZ_CP073682.1 Lanthipeptides: KAI36_RS07745_lanthipeptideNZ_CP084033.1 Lanthipeptides: LAZ93_RS07550_lanthipeptideNZ_CP085682.1 Lanthipeptides: LJR53_RS07370_lanthipeptideNZ_CP086373.1 Lanthipeptides: LMH85_RS07780_lanthipeptideNZ_CP092779.1 Lanthipeptides: MJ749_RS07440_lanthipeptideNZ_CP097766.1 Lanthipeptides: MF620_RS07485_lanthipeptideNZ_CP102865.1 Lanthipeptides: NWS42_RS21195_lanthipeptideNZ_JWJJ01000002.1 Lanthipeptides: U707_RS10390_lanthipeptideNZ_POVT01000009.1 Lanthipeptides: C1T20_RS05900_lanthipeptide

Lanthipeptides: PPE_RS07020_lanthipeptide

1

SGIICTP--GTCQTLCRITENWC

21

SG+ICTP T C+++ ++C

1

SGLICTPSCATGTLNCQVSLSFC

23

33.3%

NZ_GG692670.1:

Lanthipeptides: allorf_0419505_0419693_lanthipeptide

1

SGIICTPGTCQTLCRITENWCSLKC

25

S + CTPGTC C T CS C

3

SVMACTPGTCNNKCPNTNWLCSNVC

27

30.8%

NZ_CAAHHN010000001.1and 1 other:

NZ_CAAHHN010000001.1 Lanthipeptides: E9502_RS00800_lanthipeptide

Lanthipeptides: E9502_RS00800_lanthipeptide

1

SGIICTPGTCQTL

13

S +CTPGTC L

3

SRYLCTPGTCWKL

15

30.8%

NZ_CP013852.1:

Lanthipeptides: RSJ6_RS20525_lanthipeptide

3

IICTPGTCQTLCRIT

17

+ CTPGTC C T

4

VYCTPGTCCASCYET

18

30.6%

NZ_CP073819.1:

Lanthipeptides: KFV12_RS00360_lanthipeptide

5

CTPGTCQTLCRITENWCSLKC

25

CTPGTC C T CS C

7

CTPGTCNKECPKTNWLCSNVC

27

26.9%

NC_007296.2and 53 others:

NC_008021.1 Lanthipeptides: MGAS9429_RS04535_lanthipeptideNC_008022.1 Lanthipeptides: MGAS10270_RS04550_lanthipeptideNC_008024.1 Lanthipeptides: MGAS10750_RS04710_lanthipeptideNZ_AP023389.1 Lanthipeptides: H7675_RS05195_lanthipeptideNZ_CAAHHH010000001.1 Lanthipeptides: E9418_RS00985_lanthipeptideNZ_CAAHHX010000004.1 Lanthipeptides: E9506_RS04695_lanthipeptideNZ_CAAHKF010000003.1 Lanthipeptides: E9638_RS04280_lanthipeptideNZ_CAAHKK010000012.1 Lanthipeptides: E9649_RS06980_lanthipeptideNZ_CAAHKP010000001.1 Lanthipeptides: E9652_RS01900_lanthipeptideNZ_CAAHKP010000001.1 Lanthipeptides: E9652_RS01900_lanthipeptideNZ_CAAHKQ010000012.1 Lanthipeptides: E9664_RS06700_lanthipeptideNZ_CAAHKY010000001.1 Lanthipeptides: E9668_RS01390_lanthipeptideNZ_CAAHLP010000001.1 Lanthipeptides: E9684_RS01620_lanthipeptideNZ_CAAHLP010000001.1 Lanthipeptides: E9684_RS01620_lanthipeptideNZ_CAAHPW010000003.1 Lanthipeptides: E9938_RS03915_lanthipeptideNZ_CAAHRY010000001.1 Lanthipeptides: E9986_RS01435_lanthipeptideNZ_CAAISW010000004.1 Lanthipeptides: FAK84_RS04845_lanthipeptideNZ_CAAJDG010000002.1 Lanthipeptides: FAO89_RS02535_lanthipeptideNZ_CAAJFC010000001.1 Lanthipeptides: FAP55_RS00880_lanthipeptideNZ_CP007241.1 Lanthipeptides: STAB904_RS04335_lanthipeptideNZ_CP007560.1 Lanthipeptides: DI45_RS04910_lanthipeptideNZ_CP007561.1 Lanthipeptides: DK92_RS04585_lanthipeptideNZ_CP010449.1 Lanthipeptides: SD89_RS04040_lanthipeptideNZ_CP014278.2 Lanthipeptides: AXK13_RS04705_lanthipeptideNZ_CP014542.1 Lanthipeptides: AYM92_RS04660_lanthipeptideNZ_CP026082.1 Lanthipeptides: C2E46_RS06835_lanthipeptideNZ_CP032699.1 Lanthipeptides: D8S76_RS04455_lanthipeptideNZ_CP033336.1 Lanthipeptides: EB817_RS05220_lanthipeptideNZ_CP035431.1 Lanthipeptides: ETT68_RS04385_lanthipeptideNZ_CP035437.1 Lanthipeptides: ETT62_RS04745_lanthipeptideNZ_CP035440.1 Lanthipeptides: ETT59_RS04870_lanthipeptideNZ_CP035442.1 Lanthipeptides: ETT57_RS04405_lanthipeptideNZ_CP035443.1 Lanthipeptides: ETT56_RS04980_lanthipeptideNZ_CP035446.1 Lanthipeptides: ETT53_RS04795_lanthipeptideNZ_CP035448.1 Lanthipeptides: ETT51_RS04860_lanthipeptideNZ_CP060643.1 Lanthipeptides: H7792_RS04555_lanthipeptideNZ_CP060645.1 Lanthipeptides: H7790_RS04380_lanthipeptideNZ_CP060645.1 Lanthipeptides: H7790_RS04380_lanthipeptideNZ_HG316453.1 Lanthipeptides: SPYH293_RS03955_lanthipeptideNZ_JADPEB010000003.1 Lanthipeptides: I4U26_RS02400_lanthipeptideNZ_JAQCST010000015.1 Lanthipeptides: PGZ09_RS08160_lanthipeptideNZ_KV810616.1 Lanthipeptides: HMPREF2877_RS10480_lanthipeptideNZ_KV832031.1 Lanthipeptides: HMPREF2637_RS10850_lanthipeptideNZ_LRGI01000007.1 Lanthipeptides: AWT85_RS02610_lanthipeptideNZ_LS483330.1 Lanthipeptides: DQL25_RS05435_lanthipeptideNZ_LS483337.1 Lanthipeptides: DQL03_RS04375_lanthipeptideNZ_LS483347.1 Lanthipeptides: DQM50_RS05905_lanthipeptideNZ_LS483347.1 Lanthipeptides: DQM50_RS05905_lanthipeptideNZ_LS483382.1 Lanthipeptides: DQM89_RS04695_lanthipeptideNZ_LS483382.1 Lanthipeptides: DQM89_RS04695_lanthipeptideNZ_LS483389.1 Lanthipeptides: DQM81_RS05230_lanthipeptideNZ_LS483430.1 Lanthipeptides: DQN28_RS04075_lanthipeptideNZ_LT906439.1 Lanthipeptides: CKV83_RS02205_lanthipeptide

Lanthipeptides: M28_RS04095_lanthipeptide

1

SGIICTPGTCQTL

13

S +CTPG+C L

3

SRYLCTPGSCWKL

15

26.9%

NC_023037.2and 6 others:

NZ_CP017967.2 Lanthipeptides: PPYC1_RS07755_lanthipeptideNZ_CP017968.3 Lanthipeptides: PPYC2_RS08330_lanthipeptideNZ_CP029370.1 Lanthipeptides: DI243_RS07485_lanthipeptideNZ_CP073683.1 Lanthipeptides: KAI37_RS07495_lanthipeptideNZ_FOYG01000001.1 Lanthipeptides: BM358_RS03525_lanthipeptideNZ_PTJM01000020.1 Lanthipeptides: C5G87_RS02825_lanthipeptide

Lanthipeptides: X809_RS07820_lanthipeptide

1

SGIICTP

7

SGIICTP

1

SGIICTP

7

MIBiG 4.0 matches for COE07_RS24905

11.8%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

4

ICTPG

8

+CTPG

6

LCTPG

10

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.01 out of 30.25

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 22.59 out of 24.78

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.65 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.54 out of 26.06

Confidence: medium

LexA variant 2

Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.63 out of 24.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.52 out of 26.06

Confidence: medium

Additional weak hits (5):

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 22.01 out of 26.12

Confidence: weak

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.23 out of 33.73

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.38 out of 29.65

Confidence: weak

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12

Confidence: weak

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.40 out of 36.53

Confidence: weak

Lanthipeptides

RREFinder

TFBS Finder

Core peptide predictions

COE07_RS24905 - Class I

Cleavage pHMM score: 9.40

RODEO score: 24

Monoisotopic mass: 2690.3 Da

Molecular weight: 2692.2 Da

Number of bridges: 5

Alternative weights: (assuming N unmodified Ser/Thr residues); 2710.2 Da N = 1; 2728.2 Da N = 2

RRE predictions

: RRE type: Lanthipeptide_LanB_RRE; Location: 171 - 268; Score: 48.1

TFBS definitions

Regulator	Description
ColR	Phenol-responsive regulator
LexA variant 2	Repressor of DNA damage response
MogR	Repressor of flagellar motility genes

NZ_NUOG01000025.1 - Region 1 - terpene-precursor

Download region GenBank file

Download region SVG

Location: 487,407 - 508,297 nt. (total: 20,891 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: carboxylase

COE07_RS17155: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase

COE07_RS17120: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs: SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

COE07_RS17125: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002219.2	0.39	terpene	(-)-(R)-nephthenol	Stereum hirsutum FP-91666 SS1
BGC0000665.5	0.38	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC413

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.49	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.49	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002219.2	0.39	terpene	(-)-(R)-nephthenol	Stereum hirsutum FP-91666 SS1
BGC0000665.5	0.38	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0002284.3	0.38	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC413

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

COE07_RS17125: PT_FPPS_like

Domain 1 (32 - 295): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: IPP, DMAPP → FPP

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.49 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.66 out of 26.06

Confidence: medium

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.32 out of 25.88

Confidence: medium

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.28 out of 26.33

Confidence: medium

Additional weak hits (2):

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 23.10 out of 35.63

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.40 out of 33.14

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MogR	Repressor of flagellar motility genes
PsrA	Oleic acid responsive regulator

NZ_NUOG01000086.1 - Region 1 - lassopeptide

Download region GenBank file

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Location: 25,018 - 43,921 nt. (total: 18,904 nt) Show pHMM detection rules used

Region on contig edge.

lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lasso peptides

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: aminotransferase glycosyltransferase

COE07_RS26175: sugar transferase

smcogs: SMCOG1146: sugar transferase

COE07_RS26190: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

Hydrolases: hydrolase

COE07_RS26195: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001356.4	0.69	ribosomal	paeninodin	Paenibacillus dendritiformis C454
BGC0001634.3	0.52	ribosomal	keywimysin	Streptomyces sp. NRRL F-5702
BGC0000571.3	0.51	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454
BGC0002322.3	0.48	ribosomal	citrocin	Citrobacter pasteurii
BGC0001410.3	0.47	saccharide	polysaccharide A	Bacteroides fragilis
BGC0000868.5	0.46	other (other)	teichuronic acid	Bacillus subtilis subsp. subtilis str. 168
BGC0000765.3	0.46	saccharide	exopolysaccharide	Lactobacillus johnsonii
BGC0000800.5	0.45	saccharide	xanthan	Xanthomonas campestris
BGC0000764.3	0.45	saccharide	exopolysaccharide	Lactococcus lactis
BGC0000729.3	0.44	saccharide	capsular polysaccharide	Klebsiella pneumoniae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001356.4	0.69	ribosomal	paeninodin	Paenibacillus dendritiformis C454
BGC0001634.3	0.52	ribosomal	keywimysin	Streptomyces sp. NRRL F-5702
BGC0000571.3	0.51	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454
BGC0002322.3	0.48	ribosomal	citrocin	Citrobacter pasteurii
BGC0001410.3	0.47	saccharide	polysaccharide A	Bacteroides fragilis
BGC0000868.5	0.46	other (other)	teichuronic acid	Bacillus subtilis subsp. subtilis str. 168
BGC0000765.3	0.46	saccharide	exopolysaccharide	Lactobacillus johnsonii
BGC0000800.5	0.45	saccharide	xanthan	Xanthomonas campestris
BGC0000764.3	0.45	saccharide	exopolysaccharide	Lactococcus lactis
BGC0000729.3	0.44	saccharide	capsular polysaccharide	Klebsiella pneumoniae

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lasso peptide predictions

Lassopeptides - No core peptides found.

Lasso peptides

RREFinder

Core peptide predictions

No core peptides found.

RRE predictions

: RRE type: Stand_Alone_Lasso_RRE; Location: 13 - 96; Score: 89.8

NZ_NUOG01000004.1 - Region 1 - RiPP-like

Download region GenBank file

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Location: 38,341 - 48,652 nt. (total: 10,312 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidase

COE07_RS01470: pyruvate oxidase/decarboxylase

smcogs: SMCOG1055: pyruvate oxidase/decarboxylase

Transferases: methyltransferase

COE07_RS01460: methyltransferase

smcogs: SMCOG1248: methyltransferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000841.5	0.38	other (non-nrp beta-lactam)	alanylclavam, 2-hydroxymethylclavam, 2-formyloxymethylclavam, clavam-2-carboxylate, clavulanic acid	Streptomyces clavuligerus ATCC 27064
BGC0000495.5	0.33	ribosomal	actagardine	Actinoplanes garbadinensis
BGC0001533.5	0.20	PKS	borrelidin	Streptomyces rochei
BGC0000031.5	0.19	PKS	borrelidin	Streptomyces parvulus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000841.5	0.38	other (non-nrp beta-lactam)	alanylclavam, 2-hydroxymethylclavam, 2-formyloxymethylclavam, clavam-2-carboxylate, clavulanic acid	Streptomyces clavuligerus ATCC 27064
BGC0000495.5	0.33	ribosomal	actagardine	Actinoplanes garbadinensis
BGC0001533.5	0.20	PKS	borrelidin	Streptomyces rochei
BGC0000031.5	0.19	PKS	borrelidin	Streptomyces parvulus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.21 out of 30.25

Confidence: medium

Additional weak hits (2):

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.78 out of 26.12

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.30 out of 31.73

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
ColR	Phenol-responsive regulator

NZ_NUOG01000005.1 - Region 1 - RiPP-like,lassopeptide

Download region GenBank file

Download region SVG

Location: 3,849 - 30,385 nt. (total: 26,537 nt) Show pHMM detection rules used

Region on contig edge.

lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lasso peptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: hydrolase

COE07_RS01795: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000558.5	0.31	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0000575.5	0.30	ribosomal	lariatin	Rhodococcus jostii
BGC0001634.3	0.30	ribosomal	keywimysin	Streptomyces sp. NRRL F-5702
BGC0002306.2	0.28	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0002298.2	0.27	ribosomal	lassomycin-like peptide	Sanguibacter keddieii DSM 10542
BGC0002825.2	0.25	ribosomal	nocapeptin A	Nocardia terpenica IFM 0406
BGC0002698.2	0.24	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0001887.3	0.23	ribosomal	huazacin	Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0000516.4	0.23	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0000513.3	0.23	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000619.3	0.51	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001602.3	0.51	ribosomal	gassericin-T	Lactobacillus gasseri
BGC0001388.3	0.51	ribosomal	gassericin E	Lactobacillus gasseri
BGC0000590.5	0.51	ribosomal	microcin N	Escherichia coli
BGC0000624.3	0.50	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius
BGC0000575.5	0.50	ribosomal	lariatin	Rhodococcus jostii
BGC0001176.4	0.50	ribosomal	streptomonomicin	Streptomonospora alba
BGC0001634.3	0.50	ribosomal	keywimysin	Streptomyces sp. NRRL F-5702
BGC0000571.3	0.49	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454
BGC0000617.5	0.49	ribosomal	coagulin	Bacillus coagulans

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lasso peptide predictions

Lassopeptide(s) for COE07_RS28155

COE07_RS28155

Leader:

MKLTVGKVKEYGTFMNLTL

Full core:

AKSGKPGDGKHGKGKRGMKKA

Putative macrolactam:

AKSGKPGD

antiSMASH-DB 4.0 matches for COE07_RS28155

100.0%

NZ_NBBB01000032.1and 3 others:

NZ_NBBB01000032.1 Lassopeptides: allorf_05793_05924_lassopeptideNZ_NUOG01000005.1 Lassopeptides: COE07_RS28160_lassopeptideNZ_NUOG01000005.1 Lassopeptides: COE07_RS28155_lassopeptide

Lassopeptides: allorf_06132_06263_lassopeptide

1

AKSGKPGDGKHGKGKRGMKKA

21

AKSGKPGDGKHGKGKRGMKKA

1

AKSGKPGDGKHGKGKRGMKKA

21

57.1%

NC_006322.1and 72 others:

NC_021362.1 Lassopeptides: allorf_4042225_4042350_lassopeptideNZ_AP023088.1 Lassopeptides: allorf_0594187_0594312_lassopeptideNZ_AP025342.1 Lassopeptides: allorf_0961070_0961195_lassopeptideNZ_CABJBE010000002.1 Lassopeptides: allorf_334120_334245_lassopeptideNZ_CP010524.1 Lassopeptides: allorf_4061825_4061950_lassopeptideNZ_CP020352.1 Lassopeptides: allorf_4018279_4018404_lassopeptideNZ_CP023168.1 Lassopeptides: allorf_4201459_4201584_lassopeptideNZ_CP023665.1 Lassopeptides: allorf_4068832_4068957_lassopeptideNZ_CP033218.1 Lassopeptides: allorf_1613585_1613710_lassopeptideNZ_CP043761.1 Lassopeptides: allorf_6525412_6525540_lassopeptideNZ_CP049698.1 Lassopeptides: allorf_4058516_4058641_lassopeptideNZ_CP059494.1 Lassopeptides: allorf_3371934_3372059_lassopeptideNZ_CP068988.1 Lassopeptides: allorf_4020830_4020955_lassopeptideNZ_CP081825.1 Lassopeptides: allorf_1252758_1252886_lassopeptideNZ_CP083398.1 Lassopeptides: allorf_3088741_3088866_lassopeptideNZ_CP084682.1 Lassopeptides: allorf_4045630_4045755_lassopeptideNZ_CP090312.1 Lassopeptides: allorf_3988101_3988226_lassopeptideNZ_CP104093.1 Lassopeptides: allorf_0574703_0574828_lassopeptideNZ_CP110812.1 Lassopeptides: allorf_3160612_3160737_lassopeptideNZ_CP118744.1 Lassopeptides: allorf_4016420_4016545_lassopeptideNZ_JADNAZ010000003.1 Lassopeptides: allorf_147947_148072_lassopeptideNZ_JADNPI010000003.1 Lassopeptides: allorf_0346926_0347051_lassopeptideNZ_JAGTPZ010000028.1 Lassopeptides: allorf_0719212_0719337_lassopeptideNZ_JAHHXA010000001.1 Lassopeptides: allorf_234114_234239_lassopeptideNZ_JAJBZU010000003.1 Lassopeptides: allorf_0292203_0292328_lassopeptideNZ_JALAJD010000002.1 Lassopeptides: allorf_0333462_0333587_lassopeptideNZ_JALAJH010000002.1 Lassopeptides: allorf_205621_205746_lassopeptideNZ_JALAJI010000002.1 Lassopeptides: allorf_0713530_0713655_lassopeptideNZ_JALAJZ010000001.1 Lassopeptides: allorf_0700787_0700912_lassopeptideNZ_JALAKS010000001.1 Lassopeptides: allorf_053591_053716_lassopeptideNZ_JALALK010000001.1 Lassopeptides: allorf_0710239_0710364_lassopeptideNZ_JALALL010000012.1 Lassopeptides: allorf_159124_159249_lassopeptideNZ_JALALM010000005.1 Lassopeptides: allorf_0698852_0698977_lassopeptideNZ_JALALQ010000004.1 Lassopeptides: allorf_333021_333146_lassopeptideNZ_JALALU010000006.1 Lassopeptides: allorf_0339208_0339333_lassopeptideNZ_JALALZ010000002.1 Lassopeptides: allorf_0332050_0332175_lassopeptideNZ_JALAMC010000001.1 Lassopeptides: allorf_332573_332698_lassopeptideNZ_JALANK010000004.1 Lassopeptides: allorf_410616_410741_lassopeptideNZ_JALANL010000002.1 Lassopeptides: allorf_093009_093134_lassopeptideNZ_JALANM010000001.1 Lassopeptides: allorf_0332993_0333118_lassopeptideNZ_JALANO010000004.1 Lassopeptides: allorf_0347095_0347220_lassopeptideNZ_JALAON010000001.1 Lassopeptides: allorf_379211_379336_lassopeptideNZ_JALAOO010000003.1 Lassopeptides: allorf_069214_069339_lassopeptideNZ_JALAOQ010000004.1 Lassopeptides: allorf_0338021_0338146_lassopeptideNZ_JALAQL010000007.1 Lassopeptides: allorf_229865_229990_lassopeptideNZ_JALARN010000003.1 Lassopeptides: allorf_0700523_0700648_lassopeptideNZ_JALARO010000006.1 Lassopeptides: allorf_233062_233187_lassopeptideNZ_JALASJ010000005.1 Lassopeptides: allorf_0313268_0313393_lassopeptideNZ_JALAXE010000001.1 Lassopeptides: allorf_336072_336197_lassopeptideNZ_JALAXI010000010.1 Lassopeptides: allorf_327187_327312_lassopeptideNZ_JALAXO010000001.1 Lassopeptides: allorf_345480_345605_lassopeptideNZ_JALAXW010000003.1 Lassopeptides: allorf_0337796_0337921_lassopeptideNZ_JALAYB010000003.1 Lassopeptides: allorf_0339260_0339385_lassopeptideNZ_JALAYQ010000005.1 Lassopeptides: allorf_0332651_0332776_lassopeptideNZ_JALAYR010000003.1 Lassopeptides: allorf_0325317_0325442_lassopeptideNZ_JALHKQ010000002.1 Lassopeptides: allorf_0338015_0338140_lassopeptideNZ_KE819960.1 Lassopeptides: allorf_0718627_0718752_lassopeptideNZ_KN125579.1 Lassopeptides: allorf_1553823_1553948_lassopeptideNZ_LQYL01000021.1 Lassopeptides: allorf_340516_340641_lassopeptideNZ_MRBL01000001.1 Lassopeptides: allorf_147911_148036_lassopeptideNZ_MUEI01000002.1 Lassopeptides: allorf_0340674_0340799_lassopeptideNZ_NIJN01000012.1 Lassopeptides: allorf_433741_433866_lassopeptideNZ_NIKH01000013.1 Lassopeptides: allorf_0336426_0336551_lassopeptideNZ_NIKK01000036.1 Lassopeptides: allorf_265538_265663_lassopeptideNZ_NIKT01000037.1 Lassopeptides: allorf_071185_071310_lassopeptideNZ_NIKU01000018.1 Lassopeptides: allorf_0720911_0721036_lassopeptideNZ_NILF01000062.1 Lassopeptides: allorf_345658_345783_lassopeptideNZ_NIMP01000016.1 Lassopeptides: allorf_052906_053031_lassopeptideNZ_NKBC01000013.1 Lassopeptides: allorf_192723_192848_lassopeptideNZ_QXII01000003.1 Lassopeptides: allorf_0338451_0338576_lassopeptideNZ_RSBH01000002.1 Lassopeptides: allorf_192912_193037_lassopeptideNZ_RZIR01000001.1 Lassopeptides: allorf_4050643_4050768_lassopeptide

Lassopeptides: allorf_3863359_3863484_lassopeptide

1

AKSGKPGDGKHGKG-KRG

17

+K KPGDGK G+G KRG

1

SKKSKPGDGKFGRGVKRG

18

52.4%

NZ_CP023481.1and 1 other:

NZ_JAQCPU010000002.1 Lassopeptides: allorf_328794_328907_lassopeptide

Lassopeptides: allorf_2680773_2680886_lassopeptide

1

AKSGKPGDGKHGKGKRG

17

+K KPGDGK G+GK+G

1

SKKSKPGDGKFGRGKKG

17

with 2 more sequence matches

47.6%

NZ_CP036072.1and 20 others:

NZ_CP036072.1 Lassopeptides: allorf_073148_073267_lassopeptideNZ_CP036072.1 Lassopeptides: allorf_072992_073111_lassopeptideNZ_CP036072.1 Lassopeptides: allorf_072788_072955_lassopeptideNZ_FMBE01000014.1 Lassopeptides: allorf_124981_125100_lassopeptideNZ_FMBE01000014.1 Lassopeptides: allorf_124825_124944_lassopeptideNZ_FMBE01000014.1 Lassopeptides: allorf_124621_124788_lassopeptideNZ_FMBH01000039.1 Lassopeptides: allorf_21278_21445_lassopeptideNZ_FMBH01000039.1 Lassopeptides: allorf_21122_21241_lassopeptideNZ_FMBH01000039.1 Lassopeptides: allorf_20966_21085_lassopeptideNZ_KB976981.1 Lassopeptides: allorf_264123_264242_lassopeptideNZ_LDJQ01000026.1 Lassopeptides: allorf_16627_16794_lassopeptideNZ_LDJQ01000026.1 Lassopeptides: allorf_16471_16590_lassopeptideNZ_LDJQ01000026.1 Lassopeptides: allorf_16315_16434_lassopeptideNZ_NVLX01000026.1 Lassopeptides: allorf_29907_30074_lassopeptideNZ_NVLX01000026.1 Lassopeptides: allorf_29752_29871_lassopeptideNZ_NVLX01000026.1 Lassopeptides: allorf_29596_29715_lassopeptideNZ_VEFJ01000007.1 Lassopeptides: allorf_022530_022649_lassopeptideNZ_VEFJ01000007.1 Lassopeptides: allorf_022374_022493_lassopeptideNZ_VEFJ01000007.1 Lassopeptides: allorf_022171_022338_lassopeptideNZ_VEJP01000004.1 Lassopeptides: allorf_148376_148543_lassopeptide

Lassopeptides: allorf_073304_073423_lassopeptide

1

AKSGKPGDGKHGKGKR

16

AK KPGDG KG R

1

AKKNKPGDGTRTKGIR

16

47.6%

NZ_CP036072.1and 6 others:

NZ_FMBE01000014.1 Lassopeptides: allorf_125136_125252_lassopeptideNZ_FMBH01000039.1 Lassopeptides: allorf_20814_20930_lassopeptideNZ_KB976981.1 Lassopeptides: allorf_264278_264394_lassopeptideNZ_LDJQ01000026.1 Lassopeptides: allorf_16163_16279_lassopeptideNZ_NVLX01000026.1 Lassopeptides: allorf_29444_29560_lassopeptideNZ_VEJP01000004.1 Lassopeptides: allorf_148224_148340_lassopeptide

Lassopeptides: allorf_073459_073575_lassopeptide

1

AKSGKPGDGKHGKGKR

16

AK+ KPGDG KG R

1

AKTKKPGDGTRAKGVR

16

MIBiG 4.0 matches for COE07_RS28155

52.4%

BGC0002150.2 (MBO0654592.1):

Lasso peptide: triculamin

1

AKSGKPGDGKHGKGKRG

17

+K KPGDG GKG RG

1

SKKSKPGDGIRGKGVRG

17

Lassopeptide(s) for COE07_RS28160

COE07_RS28160

Leader:

MKLTVGKVKEYGTFMNLTL

Full core:

AKSGKPGDGKHGKGKRGMKKA

Putative macrolactam:

AKSGKPGD

antiSMASH-DB 4.0 matches for COE07_RS28160

100.0%

NZ_NBBB01000032.1and 3 others:

NZ_NBBB01000032.1 Lassopeptides: allorf_05793_05924_lassopeptideNZ_NUOG01000005.1 Lassopeptides: COE07_RS28160_lassopeptideNZ_NUOG01000005.1 Lassopeptides: COE07_RS28155_lassopeptide

Lassopeptides: allorf_06132_06263_lassopeptide

1

AKSGKPGDGKHGKGKRGMKKA

21

AKSGKPGDGKHGKGKRGMKKA

1

AKSGKPGDGKHGKGKRGMKKA

21

57.1%

NC_006322.1and 72 others:

NC_021362.1 Lassopeptides: allorf_4042225_4042350_lassopeptideNZ_AP023088.1 Lassopeptides: allorf_0594187_0594312_lassopeptideNZ_AP025342.1 Lassopeptides: allorf_0961070_0961195_lassopeptideNZ_CABJBE010000002.1 Lassopeptides: allorf_334120_334245_lassopeptideNZ_CP010524.1 Lassopeptides: allorf_4061825_4061950_lassopeptideNZ_CP020352.1 Lassopeptides: allorf_4018279_4018404_lassopeptideNZ_CP023168.1 Lassopeptides: allorf_4201459_4201584_lassopeptideNZ_CP023665.1 Lassopeptides: allorf_4068832_4068957_lassopeptideNZ_CP033218.1 Lassopeptides: allorf_1613585_1613710_lassopeptideNZ_CP043761.1 Lassopeptides: allorf_6525412_6525540_lassopeptideNZ_CP049698.1 Lassopeptides: allorf_4058516_4058641_lassopeptideNZ_CP059494.1 Lassopeptides: allorf_3371934_3372059_lassopeptideNZ_CP068988.1 Lassopeptides: allorf_4020830_4020955_lassopeptideNZ_CP081825.1 Lassopeptides: allorf_1252758_1252886_lassopeptideNZ_CP083398.1 Lassopeptides: allorf_3088741_3088866_lassopeptideNZ_CP084682.1 Lassopeptides: allorf_4045630_4045755_lassopeptideNZ_CP090312.1 Lassopeptides: allorf_3988101_3988226_lassopeptideNZ_CP104093.1 Lassopeptides: allorf_0574703_0574828_lassopeptideNZ_CP110812.1 Lassopeptides: allorf_3160612_3160737_lassopeptideNZ_CP118744.1 Lassopeptides: allorf_4016420_4016545_lassopeptideNZ_JADNAZ010000003.1 Lassopeptides: allorf_147947_148072_lassopeptideNZ_JADNPI010000003.1 Lassopeptides: allorf_0346926_0347051_lassopeptideNZ_JAGTPZ010000028.1 Lassopeptides: allorf_0719212_0719337_lassopeptideNZ_JAHHXA010000001.1 Lassopeptides: allorf_234114_234239_lassopeptideNZ_JAJBZU010000003.1 Lassopeptides: allorf_0292203_0292328_lassopeptideNZ_JALAJD010000002.1 Lassopeptides: allorf_0333462_0333587_lassopeptideNZ_JALAJH010000002.1 Lassopeptides: allorf_205621_205746_lassopeptideNZ_JALAJI010000002.1 Lassopeptides: allorf_0713530_0713655_lassopeptideNZ_JALAJZ010000001.1 Lassopeptides: allorf_0700787_0700912_lassopeptideNZ_JALAKS010000001.1 Lassopeptides: allorf_053591_053716_lassopeptideNZ_JALALK010000001.1 Lassopeptides: allorf_0710239_0710364_lassopeptideNZ_JALALL010000012.1 Lassopeptides: allorf_159124_159249_lassopeptideNZ_JALALM010000005.1 Lassopeptides: allorf_0698852_0698977_lassopeptideNZ_JALALQ010000004.1 Lassopeptides: allorf_333021_333146_lassopeptideNZ_JALALU010000006.1 Lassopeptides: allorf_0339208_0339333_lassopeptideNZ_JALALZ010000002.1 Lassopeptides: allorf_0332050_0332175_lassopeptideNZ_JALAMC010000001.1 Lassopeptides: allorf_332573_332698_lassopeptideNZ_JALANK010000004.1 Lassopeptides: allorf_410616_410741_lassopeptideNZ_JALANL010000002.1 Lassopeptides: allorf_093009_093134_lassopeptideNZ_JALANM010000001.1 Lassopeptides: allorf_0332993_0333118_lassopeptideNZ_JALANO010000004.1 Lassopeptides: allorf_0347095_0347220_lassopeptideNZ_JALAON010000001.1 Lassopeptides: allorf_379211_379336_lassopeptideNZ_JALAOO010000003.1 Lassopeptides: allorf_069214_069339_lassopeptideNZ_JALAOQ010000004.1 Lassopeptides: allorf_0338021_0338146_lassopeptideNZ_JALAQL010000007.1 Lassopeptides: allorf_229865_229990_lassopeptideNZ_JALARN010000003.1 Lassopeptides: allorf_0700523_0700648_lassopeptideNZ_JALARO010000006.1 Lassopeptides: allorf_233062_233187_lassopeptideNZ_JALASJ010000005.1 Lassopeptides: allorf_0313268_0313393_lassopeptideNZ_JALAXE010000001.1 Lassopeptides: allorf_336072_336197_lassopeptideNZ_JALAXI010000010.1 Lassopeptides: allorf_327187_327312_lassopeptideNZ_JALAXO010000001.1 Lassopeptides: allorf_345480_345605_lassopeptideNZ_JALAXW010000003.1 Lassopeptides: allorf_0337796_0337921_lassopeptideNZ_JALAYB010000003.1 Lassopeptides: allorf_0339260_0339385_lassopeptideNZ_JALAYQ010000005.1 Lassopeptides: allorf_0332651_0332776_lassopeptideNZ_JALAYR010000003.1 Lassopeptides: allorf_0325317_0325442_lassopeptideNZ_JALHKQ010000002.1 Lassopeptides: allorf_0338015_0338140_lassopeptideNZ_KE819960.1 Lassopeptides: allorf_0718627_0718752_lassopeptideNZ_KN125579.1 Lassopeptides: allorf_1553823_1553948_lassopeptideNZ_LQYL01000021.1 Lassopeptides: allorf_340516_340641_lassopeptideNZ_MRBL01000001.1 Lassopeptides: allorf_147911_148036_lassopeptideNZ_MUEI01000002.1 Lassopeptides: allorf_0340674_0340799_lassopeptideNZ_NIJN01000012.1 Lassopeptides: allorf_433741_433866_lassopeptideNZ_NIKH01000013.1 Lassopeptides: allorf_0336426_0336551_lassopeptideNZ_NIKK01000036.1 Lassopeptides: allorf_265538_265663_lassopeptideNZ_NIKT01000037.1 Lassopeptides: allorf_071185_071310_lassopeptideNZ_NIKU01000018.1 Lassopeptides: allorf_0720911_0721036_lassopeptideNZ_NILF01000062.1 Lassopeptides: allorf_345658_345783_lassopeptideNZ_NIMP01000016.1 Lassopeptides: allorf_052906_053031_lassopeptideNZ_NKBC01000013.1 Lassopeptides: allorf_192723_192848_lassopeptideNZ_QXII01000003.1 Lassopeptides: allorf_0338451_0338576_lassopeptideNZ_RSBH01000002.1 Lassopeptides: allorf_192912_193037_lassopeptideNZ_RZIR01000001.1 Lassopeptides: allorf_4050643_4050768_lassopeptide

Lassopeptides: allorf_3863359_3863484_lassopeptide

1

AKSGKPGDGKHGKG-KRG

17

+K KPGDGK G+G KRG

1

SKKSKPGDGKFGRGVKRG

18

52.4%

NZ_CP023481.1and 1 other:

NZ_JAQCPU010000002.1 Lassopeptides: allorf_328794_328907_lassopeptide

Lassopeptides: allorf_2680773_2680886_lassopeptide

1

AKSGKPGDGKHGKGKRG

17

+K KPGDGK G+GK+G

1

SKKSKPGDGKFGRGKKG

17

with 2 more sequence matches

47.6%

NZ_CP036072.1and 20 others:

NZ_CP036072.1 Lassopeptides: allorf_073148_073267_lassopeptideNZ_CP036072.1 Lassopeptides: allorf_072992_073111_lassopeptideNZ_CP036072.1 Lassopeptides: allorf_072788_072955_lassopeptideNZ_FMBE01000014.1 Lassopeptides: allorf_124981_125100_lassopeptideNZ_FMBE01000014.1 Lassopeptides: allorf_124825_124944_lassopeptideNZ_FMBE01000014.1 Lassopeptides: allorf_124621_124788_lassopeptideNZ_FMBH01000039.1 Lassopeptides: allorf_21278_21445_lassopeptideNZ_FMBH01000039.1 Lassopeptides: allorf_21122_21241_lassopeptideNZ_FMBH01000039.1 Lassopeptides: allorf_20966_21085_lassopeptideNZ_KB976981.1 Lassopeptides: allorf_264123_264242_lassopeptideNZ_LDJQ01000026.1 Lassopeptides: allorf_16627_16794_lassopeptideNZ_LDJQ01000026.1 Lassopeptides: allorf_16471_16590_lassopeptideNZ_LDJQ01000026.1 Lassopeptides: allorf_16315_16434_lassopeptideNZ_NVLX01000026.1 Lassopeptides: allorf_29907_30074_lassopeptideNZ_NVLX01000026.1 Lassopeptides: allorf_29752_29871_lassopeptideNZ_NVLX01000026.1 Lassopeptides: allorf_29596_29715_lassopeptideNZ_VEFJ01000007.1 Lassopeptides: allorf_022530_022649_lassopeptideNZ_VEFJ01000007.1 Lassopeptides: allorf_022374_022493_lassopeptideNZ_VEFJ01000007.1 Lassopeptides: allorf_022171_022338_lassopeptideNZ_VEJP01000004.1 Lassopeptides: allorf_148376_148543_lassopeptide

Lassopeptides: allorf_073304_073423_lassopeptide

1

AKSGKPGDGKHGKGKR

16

AK KPGDG KG R

1

AKKNKPGDGTRTKGIR

16

47.6%

NZ_CP036072.1and 6 others:

NZ_FMBE01000014.1 Lassopeptides: allorf_125136_125252_lassopeptideNZ_FMBH01000039.1 Lassopeptides: allorf_20814_20930_lassopeptideNZ_KB976981.1 Lassopeptides: allorf_264278_264394_lassopeptideNZ_LDJQ01000026.1 Lassopeptides: allorf_16163_16279_lassopeptideNZ_NVLX01000026.1 Lassopeptides: allorf_29444_29560_lassopeptideNZ_VEJP01000004.1 Lassopeptides: allorf_148224_148340_lassopeptide

Lassopeptides: allorf_073459_073575_lassopeptide

1

AKSGKPGDGKHGKGKR

16

AK+ KPGDG KG R

1

AKTKKPGDGTRAKGVR

16

MIBiG 4.0 matches for COE07_RS28160

52.4%

BGC0002150.2 (MBO0654592.1):

Lasso peptide: triculamin

1

AKSGKPGDGKHGKGKRG

17

+K KPGDG GKG RG

1

SKKSKPGDGIRGKGVRG

17

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (5):

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 19.76 out of 29.51

Confidence: weak

MatP

Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.27 out of 25.75

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.85 out of 33.14

Confidence: weak

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 19.72 out of 32.38

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.79 out of 33.14

Confidence: weak

Lasso peptides

RREFinder

TFBS Finder

Core peptide predictions

COE07_RS28155 - Class II: Cleavage pHMM score: -5.20; RODEO score: 17; Monoisotopic mass: 2104.2 Da; Molecular weight: 2105.5 Da; Number of bridges: 0
COE07_RS28160 - Class II: Cleavage pHMM score: -5.20; RODEO score: 16; Monoisotopic mass: 2104.2 Da; Molecular weight: 2105.5 Da; Number of bridges: 0

RRE predictions

: RRE type: Stand_Alone_Lasso_RRE; Location: 1 - 86; Score: 34.6

TFBS definitions

Regulator	Description