Select genomic region:
Overview
2.1
4.1
16.1
16.2
17.1
31.1
33.1
35.1
64.1
66.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_NUOG01000008.1 (Bacillus sp. AFS033286)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 2.1 | azole-containing-RiPP | 115,391 | 138,898 |

NZ_NUOG01000010.1 (Bacillus sp. AFS033286)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 4.1 | NI-siderophore | 51,562 | 83,276 | High | petrobactin | other:other

NZ_NUOG01000013.1 (Bacillus sp. AFS033286)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 16.1 | betalactone | 1 | 23,483 | Low | fengycin | NRPS:Type I
Region 16.2 | RiPP-like | 220,833 | 231,099 |

NZ_NUOG01000014.1 (Bacillus sp. AFS033286)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 17.1 | terpene | 61,976 | 83,829 | Low | molybdenum cofactor | other:other

NZ_NUOG01000083.1 (Bacillus sp. AFS033286)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 31.1 | lanthipeptide-class-i | 4,243 | 30,729 | Low | penisin | ribosomal:RiPP

NZ_NUOG01000025.1 (Bacillus sp. AFS033286)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 33.1 | terpene-precursor | 487,407 | 508,297 |  |

NZ_NUOG01000086.1 (Bacillus sp. AFS033286)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 35.1 | lassopeptide | 25,018 | 43,921 | High | paeninodin | ribosomal:unmodified

NZ_NUOG01000004.1 (Bacillus sp. AFS033286)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 64.1 | RiPP-like | 38,341 | 48,652 |

NZ_NUOG01000005.1 (Bacillus sp. AFS033286)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 66.1 | lassopeptide,RiPP-like | 3,849 | 30,385 |

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 2.1 | azole-containing-RiPP | 115,391 | 138,898 |
Region 4.1 | NI-siderophore | 51,562 | 83,276 | High | petrobactin | other:other
Region 16.1 | betalactone | 1 | 23,483 | Low | fengycin | NRPS:Type I
Region 16.2 | RiPP-like | 220,833 | 231,099 |
Region 17.1 | terpene | 61,976 | 83,829 | Low | molybdenum cofactor | other:other
Region 31.1 | lanthipeptide-class-i | 4,243 | 30,729 | Low | penisin | ribosomal:RiPP
Region 33.1 | terpene-precursor | 487,407 | 508,297 |  |
Region 35.1 | lassopeptide | 25,018 | 43,921 | High | paeninodin | ribosomal:unmodified
Region 64.1 | RiPP-like | 38,341 | 48,652 |
Region 66.1 | lassopeptide,RiPP-like | 3,849 | 30,385 |

No secondary metabolite regions were found in these records:
  NZ_NUOG01000007.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000009.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000011.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000012.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000015.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000016.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000017.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000018.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000023.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000019.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000020.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000021.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000022.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000026.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000027.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000028.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000029.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000024.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000075.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000076.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000077.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000078.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000079.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000080.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000081.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000082.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000084.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000085.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000087.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000088.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000089.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000090.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000091.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000092.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000093.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000094.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000001.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000030.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000031.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000032.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000033.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000034.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000035.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000036.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000038.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000039.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000002.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000042.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000043.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000044.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000046.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000047.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000049.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000003.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000052.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000058.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000062.1 (Bacillus sp. AFS033286)
  NZ_NUOG01000006.1 (Bacillus sp. AFS033286)

Compact view
NZ_NUOG01000008.1 - Region 1 - azole-containing-RiPP
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 115,391 - 138,898 nt. (total: 23,508 nt) Show pHMM detection rules used
azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Azole RiPPs
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
COE07_RS03065: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

Transferases: methyltransferase
COE07_RS03075: methyltransferase

smcogs
  SMCOG1089: methyltransferase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | azole-containing-RiPP | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001174.4 |  | 0.44 | ribosomal | corynazolicin | Corynebacterium urealyticum DSM 7111
BGC0002013.4 |  | 0.44 | ribosomal | curacozole | Streptomyces curacoi
BGC0000607.5 |  | 0.43 | ribosomal | micrococcin P1 | Macrococcus caseolyticus
BGC0001535.3 |  | 0.43 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0001146.5 |  | 0.41 | ribosomal | cyclothiazomycin C | Streptomyces sp. NRRL WC-3908
BGC0001173.5 |  | 0.41 | ribosomal | plantazolicin | Bacillus pumilus ATCC 7061
BGC0000606.5 |  | 0.39 | ribosomal | lactazole | Streptomyces lactacystinaeus
BGC0001860.4 |  | 0.39 | ribosomal | thiomuracin | Thermobispora bispora DSM 43833
BGC0000613.5 |  | 0.38 | ribosomal | thiomuracin A | Nonomuraea sp. Bp3714-39
BGC0000628.4 |  | 0.38 | ribosomal | lactocillin | Lactobacillus paragasseri JV-V03

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001174.4 |  | 0.44 | ribosomal | corynazolicin | Corynebacterium urealyticum DSM 7111
BGC0002013.4 |  | 0.44 | ribosomal | curacozole | Streptomyces curacoi
BGC0000607.5 |  | 0.43 | ribosomal | micrococcin P1 | Macrococcus caseolyticus
BGC0001535.3 |  | 0.43 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0001146.5 |  | 0.41 | ribosomal | cyclothiazomycin C | Streptomyces sp. NRRL WC-3908
BGC0001173.5 |  | 0.41 | ribosomal | plantazolicin | Bacillus pumilus ATCC 7061
BGC0000606.5 |  | 0.39 | ribosomal | lactazole | Streptomyces lactacystinaeus
BGC0001860.4 |  | 0.39 | ribosomal | thiomuracin | Thermobispora bispora DSM 43833
BGC0000613.5 |  | 0.38 | ribosomal | thiomuracin A | Nonomuraea sp. Bp3714-39
BGC0000628.4 |  | 0.38 | ribosomal | lactocillin | Lactobacillus paragasseri JV-V03

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.43 out of 32.93
Confidence: medium
Additional weak hits (1):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.85 out of 29.38
Confidence: weak
(Thi)azol(in)e containing peptide predictions
Lists the possible core peptides for each biosynthetic enzyme. Predicted tail sequences are also shown, if present.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.
No core peptides found.
RREFinder
TFBS Finder
Azole RiPPs
RRE predictions
RREfinder results sidepanel.

azole-containing-RiPP protocluster (115390...138898)
COE07_RS03090
  RRE type: Heterocycloanthracin_C_RRE
  Location: 0 - 100
  Score: 181.5
  RRE type: Thiopeptide_F_RRE
  Location: 9 - 89
  Score: 39.9

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
LexA variant 3 | Repressor of DNA damage response

Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists its possible molecular weights and the scores for cleavage site prediction and RODEO. If relevant, other features, such as macrocycle and amidation, will also be listed.
No core peptides found.
NZ_NUOG01000010.1 - Region 1 - NI-siderophore
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 51,562 - 83,276 nt. (total: 31,715 nt) Show pHMM detection rules used
NI-siderophore: IucA_IucC

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: aminotransferase
COE07_RS05610: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Hydrolases: deacetylase
COE07_RS05495: polysaccharide deacetylase

smcogs
  SMCOG1235: polysaccharide deacetylase

COE07_RS05545: polysaccharide deacetylase

smcogs
  SMCOG1235: polysaccharide deacetylase

Ligases: ligase synthase
COE07_RS05520: cysteine synthase

smcogs
  SMCOG1081: cysteine synthase

COE07_RS05575: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NI-siderophore | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000942.4 |  | 0.88 | other (other) | petrobactin | Bacillus anthracis str. Ames
BGC0000295.5 |  | 0.53 | NRPS | acinetoferrin | Acinetobacter haemolyticus
BGC0001478.5 |  | 0.51 | other (other) | desferrioxamine E | Streptomyces sp. ID38640
BGC0002692.2 |  | 0.50 | other (other) | speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B | Kribbella speibonae
BGC0002620.2 |  | 0.50 | other (other) | fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4 | Fulvivirga marina
BGC0002305.2 |  | 0.50 | other (other) | legonoxamine A, desferrioxamine B, legonoxamine B | Streptomyces sp.
BGC0001531.5 |  | 0.50 | other (other) | bisucaberin B | Tenacibaculum mesophilum
BGC0002633.2 |  | 0.48 | other (other) | schizokinen | Leptolyngbya sp. PCC 7376
BGC0001498.5 |  | 0.48 | other (other) | aerobactin | Xenorhabdus szentirmaii DSM 16338
BGC0002464.3 |  | 0.48 | other (other) | alcaligin | Bordetella pertussis Tohama I

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000942.4 |  | 0.88 | other (other) | petrobactin | Bacillus anthracis str. Ames
BGC0000295.5 |  | 0.53 | NRPS | acinetoferrin | Acinetobacter haemolyticus
BGC0001478.5 |  | 0.51 | other (other) | desferrioxamine E | Streptomyces sp. ID38640
BGC0002692.2 |  | 0.50 | other (other) | speibonoxamine, desoxy-desferrioxamine D1, desferrioxamine D1, desferrioxamine B, didesoxy-desferrioxamine D1, desoxy-desferrioxamine B, didesoxy-desferrioxamine B | Kribbella speibonae
BGC0002620.2 |  | 0.50 | other (other) | fulvivirgamide A2, fulvivirgamide B2, fulvivirgamide B3, fulvivirgamide B4 | Fulvivirga marina
BGC0002305.2 |  | 0.50 | other (other) | legonoxamine A, desferrioxamine B, legonoxamine B | Streptomyces sp.
BGC0001531.5 |  | 0.50 | other (other) | bisucaberin B | Tenacibaculum mesophilum
BGC0002633.2 |  | 0.48 | other (other) | schizokinen | Leptolyngbya sp. PCC 7376
BGC0001498.5 |  | 0.48 | other (other) | aerobactin | Xenorhabdus szentirmaii DSM 16338
BGC0002464.3 |  | 0.48 | other (other) | alcaligin | Bordetella pertussis Tohama I

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.61 out of 29.38
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.57 out of 18.57
Confidence: strong
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.55 out of 19.26
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.72 out of 29.38
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.18 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.18 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.85 out of 28.19
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 15.13 out of 18.16
Confidence: strong
Additional weak hits (7):
AfsQ1
Description: Two-component system AfsQ1-Q2, activator of antibiotic production
Species: Streptomyces coelicolor
Score: 16.58 out of 19.52
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.23 out of 30.11
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.92 out of 30.11
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.12 out of 29.38
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.91 out of 29.38
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.84 out of 32.74
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.60 out of 36.54
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CRP | Cyclic AMP receptor protein
FuR variant 1 | Ferric Uptake Regulator
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_NUOG01000013.1 - Region 1 - betalactone
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1 - 23,483 nt. (total: 23,483 nt) Show pHMM detection rules used
Region on contig edge.
betalactone: (HMGL-like and AMP-binding)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
COE07_RS08290: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

Transferases: acetyltransferase carboxylase methyltransferase transferase
COE07_RS08295: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

COE07_RS08315: acetyl-CoA carboxylase, carboxyl transferase,

smcogs
  SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

COE07_RS08340: GCN5-related N-acetyltransferase

smcogs
  SMCOG1111: GCN5-related N-acetyltransferase

COE07_RS08380: methyltransferase

smcogs
  SMCOG1248: methyltransferase

Lyases: hydratase
COE07_RS08310: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase
COE07_RS08305: 2-isopropylmalate synthase

smcogs
  SMCOG1271: 2-isopropylmalate synthase

COE07_RS08320: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | betalactone | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002284.3 |  | 0.55 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000131.5 |  | 0.46 | PKS | pyrrolomycin | Streptomyces sp. UC 11065
BGC0000706.3 |  | 0.46 | saccharide | kanamycin | Streptomyces kanamyceticus
BGC0000234.5 |  | 0.43 | PKS | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000623.3 |  | 0.42 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0001226.4 |  | 0.42 | ribosomal | streptocollin | Streptomyces collinus Tu 365
BGC0000563.4 |  | 0.42 | ribosomal | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0001103.5 |  | 0.42 | NRPS, PKS | mycosubtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0002700.2 |  | 0.41 | ribosomal | bacinapeptin | Bacillus nakamurai
BGC0001095.5 |  | 0.41 | NRPS | fengycin | Bacillus velezensis FZB42

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002284.3 |  | 0.55 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000131.5 |  | 0.46 | PKS | pyrrolomycin | Streptomyces sp. UC 11065
BGC0000706.3 |  | 0.46 | saccharide | kanamycin | Streptomyces kanamyceticus
BGC0000234.5 |  | 0.43 | PKS | jadomycin | Streptomyces venezuelae ATCC 10712
BGC0000623.3 |  | 0.42 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0001226.4 |  | 0.42 | ribosomal | streptocollin | Streptomyces collinus Tu 365
BGC0000563.4 |  | 0.42 | ribosomal | venezuelin | Streptomyces venezuelae ATCC 10712
BGC0001103.5 |  | 0.42 | NRPS, PKS | mycosubtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0002700.2 |  | 0.41 | ribosomal | bacinapeptin | Bacillus nakamurai
BGC0001095.5 |  | 0.41 | NRPS | fengycin | Bacillus velezensis FZB42

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.52 out of 25.88
Confidence: medium
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 18.42 out of 20.47
Confidence: medium
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.94 out of 25.31
Confidence: medium
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.67 out of 25.31
Confidence: medium
Additional weak hits (2):
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.13 out of 25.88
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 25.44 out of 36.53
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CatR | H2O2-responsive repressor
PsrA | Oleic acid responsive regulator
VqsM | Regulator of quorum-sensing signalling systems

NZ_NUOG01000013.1 - Region 2 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 220,833 - 231,099 nt. (total: 10,267 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: aminotransferase
COE07_RS09595: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Hydrolases: hydrolase
COE07_RS09565: beta-lactamase

smcogs
  SMCOG1053: beta-lactamase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001994.4 |  | 0.40 | other (other) | β-ethynylserine | Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0001488.3 |  | 0.36 | other (other) | 4-formylaminooxyvinylglycine | Pseudomonas fluorescens WH6
BGC0001964.2 |  | 0.28 | PKS | alkylpyrone-407, alkylpyrone-393 | Cystobacterineae bacterium
BGC0002536.3 |  | 0.28 | NRPS | alazopeptin | Kitasatospora azatica KCTC 9699
BGC0000721.4 |  | 0.26 | saccharide | tobramycin | Streptoalloteichus tenebrarius
BGC0000381.5 |  | 0.26 | NRPS | lichenysin | Bacillus licheniformis DSM 13 = ATCC 14580
BGC0002440.3 |  | 0.24 | NRPS | longicatenamide B, longicatenamide C, longicatenamide A, longicatenamide D | Streptomyces sp.
BGC0000388.5 |  | 0.24 | NRPS | mannopeptimycin | Streptomyces hygroscopicus
BGC0001814.5 |  | 0.23 | NRPS | ulleungmycin | Streptomyces sp. KCB13F003
BGC0001406.5 |  | 0.22 | NRPS | telomycin | Streptomyces canus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001994.4 |  | 0.40 | other (other) | β-ethynylserine | Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0001488.3 |  | 0.36 | other (other) | 4-formylaminooxyvinylglycine | Pseudomonas fluorescens WH6
BGC0001964.2 |  | 0.28 | PKS | alkylpyrone-407, alkylpyrone-393 | Cystobacterineae bacterium
BGC0002536.3 |  | 0.28 | NRPS | alazopeptin | Kitasatospora azatica KCTC 9699
BGC0000721.4 |  | 0.26 | saccharide | tobramycin | Streptoalloteichus tenebrarius
BGC0000381.5 |  | 0.26 | NRPS | lichenysin | Bacillus licheniformis DSM 13 = ATCC 14580
BGC0002440.3 |  | 0.24 | NRPS | longicatenamide B, longicatenamide C, longicatenamide A, longicatenamide D | Streptomyces sp.
BGC0000388.5 |  | 0.24 | NRPS | mannopeptimycin | Streptomyces hygroscopicus
BGC0001814.5 |  | 0.23 | NRPS | ulleungmycin | Streptomyces sp. KCB13F003
BGC0001406.5 |  | 0.22 | NRPS | telomycin | Streptomyces canus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.51 out of 20.97
Confidence: medium
Additional weak hits (2):
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.04 out of 25.88
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 22.00 out of 30.98
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A

NZ_NUOG01000014.1 - Region 1 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 61,976 - 83,829 nt. (total: 21,854 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
COE07_RS10635: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

COE07_RS10640: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Lyases: lyase
COE07_RS10610: argininosuccinate lyase/adenylosuccinate lyase

smcogs
  SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000917.3 |  | 0.52 | other (other) | molybdenum cofactor | Rhodobacter capsulatus
BGC0000888.5 |  | 0.49 | other (other) | bacilysin | Bacillus sp. CS93
BGC0000866.5 |  | 0.46 | other (other) | polyhydroxyalkanoate | Burkholderia sp. DSM 9242
BGC0001928.2 |  | 0.46 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0000916.5 |  | 0.46 | other (other) | molybdenum cofactor | Staphylococcus carnosus
BGC0000812.3 |  | 0.45 | other (other) | huperzine A | Shiraia sp. slf14
BGC0000231.5 |  | 0.42 | PKS | griseusin A, griseusin B | Streptomyces griseus
BGC0001605.3 |  | 0.42 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0001197.5 |  | 0.42 | PKS | frankiamicin | Frankia sp. EAN1pec
BGC0000234.5 |  | 0.41 | PKS | jadomycin | Streptomyces venezuelae ATCC 10712

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000917.3 |  | 0.52 | other (other) | molybdenum cofactor | Rhodobacter capsulatus
BGC0000888.5 |  | 0.49 | other (other) | bacilysin | Bacillus sp. CS93
BGC0000866.5 |  | 0.46 | other (other) | polyhydroxyalkanoate | Burkholderia sp. DSM 9242
BGC0001928.2 |  | 0.46 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0000916.5 |  | 0.46 | other (other) | molybdenum cofactor | Staphylococcus carnosus
BGC0000812.3 |  | 0.45 | other (other) | huperzine A | Shiraia sp. slf14
BGC0000231.5 |  | 0.42 | PKS | griseusin A, griseusin B | Streptomyces griseus
BGC0001605.3 |  | 0.42 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0001197.5 |  | 0.42 | PKS | frankiamicin | Frankia sp. EAN1pec
BGC0000234.5 |  | 0.41 | PKS | jadomycin | Streptomyces venezuelae ATCC 10712

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene | hopanoid |  | C30 | hopanoid skeleton | unknown
triterpene | polypodane |  | C30 | polypodane skeleton | unknown

Genes with terpene domains:
COE07_RS10650: T2TS
Domain 1 (4 - 614): Type 2 terpene synthase
Subtype: Squalene substrate

Reactions:
  squalene → hopanoid
  squalene → polypodane

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
No hits above weak threshold.
Weak hits (1):
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 20.85 out of 30.22
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.
No acronyms to display
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---

NZ_NUOG01000083.1 - Region 1 - lanthipeptide-class-i
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 4,243 - 30,729 nt. (total: 26,487 nt) Show pHMM detection rules used
lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: cyclase dehydratase
COE07_RS24890: Lanthionine synthetase C family protein

smcogs
  SMCOG1140: Lanthionine synthetase C family protein

COE07_RS24900: Lantibiotic dehydratase domain protein

smcogs
  SMCOG1155: Lantibiotic dehydratase domain protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-i | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002576.2 |  | 0.76 | ribosomal | mechercharmycin | Thermoactinomyces sp.
BGC0001289.5 |  | 0.61 | ribosomal | penisin | Paenibacillus ehimensis
BGC0000542.3 |  | 0.57 | ribosomal | paenicidin B | Paenibacillus terrae
BGC0000541.5 |  | 0.57 | ribosomal | paenicidin A | Paenibacillus polymyxa
BGC0000538.3 |  | 0.56 | ribosomal | nisin Z | Lactococcus lactis
BGC0001210.5 |  | 0.55 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000560.5 |  | 0.52 | ribosomal | subtilomycin | Bacillus subtilis
BGC0001727.3 |  | 0.52 | ribosomal | paenilan | Paenibacillus polymyxa E681
BGC0000515.4 |  | 0.52 | ribosomal | geobacillin I | Geobacillus thermodenitrificans NG80-2
BGC0000506.4 |  | 0.49 | ribosomal | entianin | Bacillus subtilis subsp. spizizenii

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002576.2 |  | 0.76 | ribosomal | mechercharmycin | Thermoactinomyces sp.
BGC0001289.5 |  | 0.61 | ribosomal | penisin | Paenibacillus ehimensis
BGC0000542.3 |  | 0.57 | ribosomal | paenicidin B | Paenibacillus terrae
BGC0000541.5 |  | 0.57 | ribosomal | paenicidin A | Paenibacillus polymyxa
BGC0000538.3 |  | 0.56 | ribosomal | nisin Z | Lactococcus lactis
BGC0001210.5 |  | 0.55 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000560.5 |  | 0.52 | ribosomal | subtilomycin | Bacillus subtilis
BGC0001727.3 |  | 0.52 | ribosomal | paenilan | Paenibacillus polymyxa E681
BGC0000515.4 |  | 0.52 | ribosomal | geobacillin I | Geobacillus thermodenitrificans NG80-2
BGC0000506.4 |  | 0.49 | ribosomal | entianin | Bacillus subtilis subsp. spizizenii

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for COE07_RS24900

COE07_RS24905
Leader:
MENNKLFDLDVQVSSNLEEQGGVEPR
Core:
S G I I C T P G T C Q T L C R I T E N W C S L K C S
Core with dehydrations:
Dha G I I Cys Dhb P G Dhb Cys Q Dhb L Cys R I Dhb E N W Cys Dha L K Cys Dha

#### antiSMASH-DB 4.0 matches for COE07_RS24905

100.0%
NZ_NBBB01000022.1 and 1 other:
NZ_NUOG01000083.1 Lanthipeptides: COE07_RS24905_lanthipeptide
Lanthipeptides: B6F67_RS25205_lanthipeptide
1
S G I I C T P G T C Q T L C R I T E N W C S L K C S
26
S G I I C T P G T C Q T L C R I T E N W C S L K C S
1
S G I I C T P G T C Q T L C R I T E N W C S L K C S
26
38.5%
NZ_JAIFIS010000001.1:
Lanthipeptides: K1X09_RS26315_lanthipeptide
1
S G I I C T P G--T C Q T L C R I T E N W C
21
S G+I C T P T C+I+ ++C
1
S G L I C T P S C L T G T L N C K I S L S F C
23
38.5%
NZ_JAKVDC010000001.1:
Lanthipeptides: MKN04_RS02755_lanthipeptide
1
S G I I C T P--G T C Q T L C R I T E N W C
21
S G I I C T P T C+++ ++C
1
S G I I C T P S C A T G T L N C Q V S L S F C
23
with 27 more sequence matches
Only the first 10 are displayed here.
38.5%
NZ_WTWY01000020.1:
Lanthipeptides: GQY55_RS27090_lanthipeptide
1
S G I I C T P G--T C Q T L C R I T E N W C
21
S G I C T P T C+I+ ++C
1
S G F I C T P S C L T G T L N C K I S L S F C
23
37.5%
NZ_NGMO01000003.1 and 3 others:
NZ_NGMO01000003.1 Lanthipeptides: allorf_391705_391890_lanthipeptide NZ_NGMO01000003.1 Lanthipeptides: allorf_392307_392492_lanthipeptide NZ_NGMO01000003.1 Lanthipeptides: allorf_391705_391890_lanthipeptide
Lanthipeptides: allorf_392307_392492_lanthipeptide
3
I I C T P G T C Q T L C R I T E N W C S L K C
25
I C T P G T C + C T C S C
1
I A C T P G T C N S N C P Q T N W L C S N V C
23
36.1%
NZ_CP081833.1 and 1 other:
NZ_CP097053.1 Lanthipeptides: allorf_0094918_0095106_lanthipeptide
Lanthipeptides: allorf_0004055_0004243_lanthipeptide
1
S G I I C T P G T C Q T L C R I T E N W C S L K C
25
S I C T P G T C C T C S C
3
S V I A C T P G T C N N K C P N T N W L C S N V C
27
34.6%
NC_014483.2 and 17 others:
NC_014622.2 Lanthipeptides: PPSC2_RS36205_lanthipeptide NC_017542.1 Lanthipeptides: PPM_RS07465_lanthipeptide NZ_CP006872.1 Lanthipeptides: PPSQR21_RS07740_lanthipeptide NZ_CP023711.1 Lanthipeptides: CPY53_RS22235_lanthipeptide NZ_CP025957.1 Lanthipeptides: C1A50_RS07530_lanthipeptide NZ_CP029370.1 Lanthipeptides: DI243_RS07495_lanthipeptide NZ_CP040829.1 Lanthipeptides: FGY93_RS00500_lanthipeptide NZ_CP049598.1 Lanthipeptides: G7L40_RS00115_lanthipeptide NZ_CP073682.1 Lanthipeptides: KAI36_RS07745_lanthipeptide NZ_CP084033.1 Lanthipeptides: LAZ93_RS07550_lanthipeptide NZ_CP085682.1 Lanthipeptides: LJR53_RS07370_lanthipeptide NZ_CP086373.1 Lanthipeptides: LMH85_RS07780_lanthipeptide NZ_CP092779.1 Lanthipeptides: MJ749_RS07440_lanthipeptide NZ_CP097766.1 Lanthipeptides: MF620_RS07485_lanthipeptide NZ_CP102865.1 Lanthipeptides: NWS42_RS21195_lanthipeptide NZ_JWJJ01000002.1 Lanthipeptides: U707_RS10390_lanthipeptide NZ_POVT01000009.1 Lanthipeptides: C1T20_RS05900_lanthipeptide
Lanthipeptides: PPE_RS07020_lanthipeptide
1
S G I I C T P--G T C Q T L C R I T E N W C
21
S G+I C T P T C+++ ++C
1
S G L I C T P S C A T G T L N C Q V S L S F C
23
33.3%
NZ_GG692670.1:
Lanthipeptides: allorf_0419505_0419693_lanthipeptide
1
S G I I C T P G T C Q T L C R I T E N W C S L K C
25
S + C T P G T C C T C S C
3
S V M A C T P G T C N N K C P N T N W L C S N V C
27
30.8%
NZ_CAAHHN010000001.1 and 1 other:
NZ_CAAHHN010000001.1 Lanthipeptides: E9502_RS00800_lanthipeptide
Lanthipeptides: E9502_RS00800_lanthipeptide
1
S G I I C T P G T C Q T L
13
S +C T P G T C L
3
S R Y L C T P G T C W K L
15
30.8%
NZ_CP013852.1:
Lanthipeptides: RSJ6_RS20525_lanthipeptide
3
I I C T P G T C Q T L C R I T
17
+ C T P G T C C T
4
V Y C T P G T C C A S C Y E T
18
30.6%
NZ_CP073819.1:
Lanthipeptides: KFV12_RS00360_lanthipeptide
5
C T P G T C Q T L C R I T E N W C S L K C
25
C T P G T C C T C S C
7
C T P G T C N K E C P K T N W L C S N V C
27
26.9%
NC_007296.2 and 53 others:
NC_008021.1 Lanthipeptides: MGAS9429_RS04535_lanthipeptide NC_008022.1 Lanthipeptides: MGAS10270_RS04550_lanthipeptide NC_008024.1 Lanthipeptides: MGAS10750_RS04710_lanthipeptide NZ_AP023389.1 Lanthipeptides: H7675_RS05195_lanthipeptide NZ_CAAHHH010000001.1 Lanthipeptides: E9418_RS00985_lanthipeptide NZ_CAAHHX010000004.1 Lanthipeptides: E9506_RS04695_lanthipeptide NZ_CAAHKF010000003.1 Lanthipeptides: E9638_RS04280_lanthipeptide NZ_CAAHKK010000012.1 Lanthipeptides: E9649_RS06980_lanthipeptide NZ_CAAHKP010000001.1 Lanthipeptides: E9652_RS01900_lanthipeptide NZ_CAAHKP010000001.1 Lanthipeptides: E9652_RS01900_lanthipeptide NZ_CAAHKQ010000012.1 Lanthipeptides: E9664_RS06700_lanthipeptide NZ_CAAHKY010000001.1 Lanthipeptides: E9668_RS01390_lanthipeptide NZ_CAAHLP010000001.1 Lanthipeptides: E9684_RS01620_lanthipeptide NZ_CAAHLP010000001.1 Lanthipeptides: E9684_RS01620_lanthipeptide NZ_CAAHPW010000003.1 Lanthipeptides: E9938_RS03915_lanthipeptide NZ_CAAHRY010000001.1 Lanthipeptides: E9986_RS01435_lanthipeptide NZ_CAAISW010000004.1 Lanthipeptides: FAK84_RS04845_lanthipeptide NZ_CAAJDG010000002.1 Lanthipeptides: FAO89_RS02535_lanthipeptide NZ_CAAJFC010000001.1 Lanthipeptides: FAP55_RS00880_lanthipeptide NZ_CP007241.1 Lanthipeptides: STAB904_RS04335_lanthipeptide NZ_CP007560.1 Lanthipeptides: DI45_RS04910_lanthipeptide NZ_CP007561.1 Lanthipeptides: DK92_RS04585_lanthipeptide NZ_CP010449.1 Lanthipeptides: SD89_RS04040_lanthipeptide NZ_CP014278.2 Lanthipeptides: AXK13_RS04705_lanthipeptide NZ_CP014542.1 Lanthipeptides: AYM92_RS04660_lanthipeptide NZ_CP026082.1 Lanthipeptides: C2E46_RS06835_lanthipeptide NZ_CP032699.1 Lanthipeptides: D8S76_RS04455_lanthipeptide NZ_CP033336.1 Lanthipeptides: EB817_RS05220_lanthipeptide NZ_CP035431.1 Lanthipeptides: ETT68_RS04385_lanthipeptide NZ_CP035437.1 Lanthipeptides: ETT62_RS04745_lanthipeptide NZ_CP035440.1 Lanthipeptides: ETT59_RS04870_lanthipeptide NZ_CP035442.1 Lanthipeptides: ETT57_RS04405_lanthipeptide NZ_CP035443.1 Lanthipeptides: ETT56_RS04980_lanthipeptide NZ_CP035446.1 Lanthipeptides: ETT53_RS04795_lanthipeptide NZ_CP035448.1 Lanthipeptides: ETT51_RS04860_lanthipeptide NZ_CP060643.1 Lanthipeptides: H7792_RS04555_lanthipeptide NZ_CP060645.1 Lanthipeptides: H7790_RS04380_lanthipeptide NZ_CP060645.1 Lanthipeptides: H7790_RS04380_lanthipeptide NZ_HG316453.1 Lanthipeptides: SPYH293_RS03955_lanthipeptide NZ_JADPEB010000003.1 Lanthipeptides: I4U26_RS02400_lanthipeptide NZ_JAQCST010000015.1 Lanthipeptides: PGZ09_RS08160_lanthipeptide NZ_KV810616.1 Lanthipeptides: HMPREF2877_RS10480_lanthipeptide NZ_KV832031.1 Lanthipeptides: HMPREF2637_RS10850_lanthipeptide NZ_LRGI01000007.1 Lanthipeptides: AWT85_RS02610_lanthipeptide NZ_LS483330.1 Lanthipeptides: DQL25_RS05435_lanthipeptide NZ_LS483337.1 Lanthipeptides: DQL03_RS04375_lanthipeptide NZ_LS483347.1 Lanthipeptides: DQM50_RS05905_lanthipeptide NZ_LS483347.1 Lanthipeptides: DQM50_RS05905_lanthipeptide NZ_LS483382.1 Lanthipeptides: DQM89_RS04695_lanthipeptide NZ_LS483382.1 Lanthipeptides: DQM89_RS04695_lanthipeptide NZ_LS483389.1 Lanthipeptides: DQM81_RS05230_lanthipeptide NZ_LS483430.1 Lanthipeptides: DQN28_RS04075_lanthipeptide NZ_LT906439.1 Lanthipeptides: CKV83_RS02205_lanthipeptide
Lanthipeptides: M28_RS04095_lanthipeptide
1
S G I I C T P G T C Q T L
13
S +C T P G+C L
3
S R Y L C T P G S C W K L
15
26.9%
NC_023037.2 and 6 others:
NZ_CP017967.2 Lanthipeptides: PPYC1_RS07755_lanthipeptide NZ_CP017968.3 Lanthipeptides: PPYC2_RS08330_lanthipeptide NZ_CP029370.1 Lanthipeptides: DI243_RS07485_lanthipeptide NZ_CP073683.1 Lanthipeptides: KAI37_RS07495_lanthipeptide NZ_FOYG01000001.1 Lanthipeptides: BM358_RS03525_lanthipeptide NZ_PTJM01000020.1 Lanthipeptides: C5G87_RS02825_lanthipeptide
Lanthipeptides: X809_RS07820_lanthipeptide
1
S G I I C T P
7
S G I I C T P
1
S G I I C T P
7

#### MIBiG 4.0 matches for COE07_RS24905

11.8%
BGC0000535.4 (ADJ56352.1):
Lanthipeptide: nisin A
4
I C T P G
8
+C T P G
6
L C T P G
10

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.01 out of 30.25
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 22.59 out of 24.78
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.65 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.54 out of 26.06
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 21.63 out of 24.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.52 out of 26.06
Confidence: medium
Additional weak hits (5):
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 22.01 out of 26.12
Confidence: weak
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 22.23 out of 33.73
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 22.38 out of 29.65
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12
Confidence: weak
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 22.40 out of 36.53
Confidence: weak
Lanthipeptides
RREFinder
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

COE07_RS24905 - Class I
  Cleavage pHMM score: 9.40
  RODEO score: 24
  Monoisotopic mass: 2690.3 Da
  Molecular weight: 2692.2 Da
  Number of bridges: 5
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2710.2 Da N = 1
    2728.2 Da N = 2

RRE predictions
RREfinder results sidepanel.

lanthipeptide-class-i protocluster (4242...30729)
COE07_RS24900
  RRE type: Lanthipeptide_LanB_RRE
  Location: 171 - 268
  Score: 48.1

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ColR | Phenol-responsive regulator
LexA variant 2 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes

NZ_NUOG01000025.1 - Region 1 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 487,407 - 508,297 nt. (total: 20,891 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: carboxylase
COE07_RS17155: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase
COE07_RS17120: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

COE07_RS17125: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002219.2 |  | 0.39 | terpene | (-)-(R)-nephthenol | Stereum hirsutum FP-91666 SS1
BGC0000665.5 |  | 0.38 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0002284.3 |  | 0.38 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000639.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC413

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002219.2 |  | 0.39 | terpene | (-)-(R)-nephthenol | Stereum hirsutum FP-91666 SS1
BGC0000665.5 |  | 0.38 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0002284.3 |  | 0.38 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000639.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC413

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
COE07_RS17125: PT_FPPS_like
Domain 1 (32 - 295): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  IPP, DMAPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.49 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.66 out of 26.06
Confidence: medium
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.32 out of 25.88
Confidence: medium
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.28 out of 26.33
Confidence: medium
Additional weak hits (2):
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 23.10 out of 35.63
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.40 out of 33.14
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MogR | Repressor of flagellar motility genes
PsrA | Oleic acid responsive regulator

NZ_NUOG01000086.1 - Region 1 - lassopeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 25,018 - 43,921 nt. (total: 18,904 nt) Show pHMM detection rules used
Region on contig edge.
lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lasso peptides
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: aminotransferase glycosyltransferase
COE07_RS26175: sugar transferase

smcogs
  SMCOG1146: sugar transferase

COE07_RS26190: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs
  SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

Hydrolases: hydrolase
COE07_RS26195: asparagine synthase (glutamine-hydrolyzing)

smcogs
  SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lassopeptide | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001356.4 |  | 0.69 | ribosomal | paeninodin | Paenibacillus dendritiformis C454
BGC0001634.3 |  | 0.52 | ribosomal | keywimysin | Streptomyces sp. NRRL F-5702
BGC0000571.3 |  | 0.51 | ribosomal | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0002322.3 |  | 0.48 | ribosomal | citrocin | Citrobacter pasteurii
BGC0001410.3 |  | 0.47 | saccharide | polysaccharide A | Bacteroides fragilis
BGC0000868.5 |  | 0.46 | other (other) | teichuronic acid | Bacillus subtilis subsp. subtilis str. 168
BGC0000765.3 |  | 0.46 | saccharide | exopolysaccharide | Lactobacillus johnsonii
BGC0000800.5 |  | 0.45 | saccharide | xanthan | Xanthomonas campestris
BGC0000764.3 |  | 0.45 | saccharide | exopolysaccharide | Lactococcus lactis
BGC0000729.3 |  | 0.44 | saccharide | capsular polysaccharide | Klebsiella pneumoniae

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001356.4 |  | 0.69 | ribosomal | paeninodin | Paenibacillus dendritiformis C454
BGC0001634.3 |  | 0.52 | ribosomal | keywimysin | Streptomyces sp. NRRL F-5702
BGC0000571.3 |  | 0.51 | ribosomal | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0002322.3 |  | 0.48 | ribosomal | citrocin | Citrobacter pasteurii
BGC0001410.3 |  | 0.47 | saccharide | polysaccharide A | Bacteroides fragilis
BGC0000868.5 |  | 0.46 | other (other) | teichuronic acid | Bacillus subtilis subsp. subtilis str. 168
BGC0000765.3 |  | 0.46 | saccharide | exopolysaccharide | Lactobacillus johnsonii
BGC0000800.5 |  | 0.45 | saccharide | xanthan | Xanthomonas campestris
BGC0000764.3 |  | 0.45 | saccharide | exopolysaccharide | Lactococcus lactis
BGC0000729.3 |  | 0.44 | saccharide | capsular polysaccharide | Klebsiella pneumoniae

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lasso peptide predictions
Lists the possible core peptides for each biosynthetic enzyme. Each core peptide shows the leader and core peptide sequences.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.
Lassopeptides - No core peptides found.
Lasso peptides
RREFinder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of disulfide bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.
No core peptides found.
RRE predictions
RREfinder results sidepanel.

lassopeptide protocluster (25017...43921)
COE07_RS26205
  RRE type: Stand_Alone_Lasso_RRE
  Location: 13 - 96
  Score: 89.8

NZ_NUOG01000004.1 - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 38,341 - 48,652 nt. (total: 10,312 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidase
COE07_RS01470: pyruvate oxidase/decarboxylase

smcogs
  SMCOG1055: pyruvate oxidase/decarboxylase

Transferases: methyltransferase
COE07_RS01460: methyltransferase

smcogs
  SMCOG1248: methyltransferase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000841.5 |  | 0.38 | other (non-nrp beta-lactam) | alanylclavam, 2-hydroxymethylclavam, 2-formyloxymethylclavam, clavam-2-carboxylate, clavulanic acid | Streptomyces clavuligerus ATCC 27064
BGC0000495.5 |  | 0.33 | ribosomal | actagardine | Actinoplanes garbadinensis
BGC0001533.5 |  | 0.20 | PKS | borrelidin | Streptomyces rochei
BGC0000031.5 |  | 0.19 | PKS | borrelidin | Streptomyces parvulus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000841.5 |  | 0.38 | other (non-nrp beta-lactam) | alanylclavam, 2-hydroxymethylclavam, 2-formyloxymethylclavam, clavam-2-carboxylate, clavulanic acid | Streptomyces clavuligerus ATCC 27064
BGC0000495.5 |  | 0.33 | ribosomal | actagardine | Actinoplanes garbadinensis
BGC0001533.5 |  | 0.20 | PKS | borrelidin | Streptomyces rochei
BGC0000031.5 |  | 0.19 | PKS | borrelidin | Streptomyces parvulus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.21 out of 30.25
Confidence: medium
Additional weak hits (2):
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.78 out of 26.12
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.30 out of 31.73
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ColR | Phenol-responsive regulator

NZ_NUOG01000005.1 - Region 1 - RiPP-like,lassopeptide
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,849 - 30,385 nt. (total: 26,537 nt) Show pHMM detection rules used
Region on contig edge.
lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lasso peptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: hydrolase
COE07_RS01795: asparagine synthase (glutamine-hydrolyzing)

smcogs
  SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lassopeptide | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0000558.5 |  |  | 0.31 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0000575.5 |  |  | 0.30 | ribosomal | lariatin | Rhodococcus jostii
BGC0001634.3 |  |  | 0.30 | ribosomal | keywimysin | Streptomyces sp. NRRL F-5702
BGC0002306.2 |  |  | 0.28 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0002298.2 |  |  | 0.27 | ribosomal | lassomycin-like peptide | Sanguibacter keddieii DSM 10542
BGC0002825.2 |  |  | 0.25 | ribosomal | nocapeptin A | Nocardia terpenica IFM 0406
BGC0002698.2 |  |  | 0.24 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0001887.3 |  |  | 0.23 | ribosomal | huazacin | Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0000516.4 |  |  | 0.23 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000513.3 |  |  | 0.23 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000619.3 |  | 0.51 | ribosomal | gassericin T | Lactobacillus gasseri
BGC0001602.3 |  | 0.51 | ribosomal | gassericin-T | Lactobacillus gasseri
BGC0001388.3 |  | 0.51 | ribosomal | gassericin E | Lactobacillus gasseri
BGC0000590.5 |  | 0.51 | ribosomal | microcin N | Escherichia coli
BGC0000624.3 |  | 0.50 | ribosomal | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0000575.5 |  | 0.50 | ribosomal | lariatin | Rhodococcus jostii
BGC0001176.4 |  | 0.50 | ribosomal | streptomonomicin | Streptomonospora alba
BGC0001634.3 |  | 0.50 | ribosomal | keywimysin | Streptomyces sp. NRRL F-5702
BGC0000571.3 |  | 0.49 | ribosomal | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0000617.5 |  | 0.49 | ribosomal | coagulin | Bacillus coagulans

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lasso peptide predictions
Lists the possible core peptides for each biosynthetic enzyme. Each core peptide shows the leader and core peptide sequences.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lassopeptide(s) for COE07_RS28155

COE07_RS28155
Leader:
MKLTVGKVKEYGTFMNLTL
Full core:
A K S G K P G D G K H G K G K R G M K K A
Putative macrolactam:
A K S G K P G D

#### antiSMASH-DB 4.0 matches for COE07_RS28155

100.0%
NZ_NBBB01000032.1 and 3 others:
NZ_NBBB01000032.1 Lassopeptides: allorf_05793_05924_lassopeptide NZ_NUOG01000005.1 Lassopeptides: COE07_RS28160_lassopeptide NZ_NUOG01000005.1 Lassopeptides: COE07_RS28155_lassopeptide
Lassopeptides: allorf_06132_06263_lassopeptide
1
A K S G K P G D G K H G K G K R G M K K A
21
A K S G K P G D G K H G K G K R G M K K A
1
A K S G K P G D G K H G K G K R G M K K A
21
57.1%
NC_006322.1 and 72 others:
NC_021362.1 Lassopeptides: allorf_4042225_4042350_lassopeptide NZ_AP023088.1 Lassopeptides: allorf_0594187_0594312_lassopeptide NZ_AP025342.1 Lassopeptides: allorf_0961070_0961195_lassopeptide NZ_CABJBE010000002.1 Lassopeptides: allorf_334120_334245_lassopeptide NZ_CP010524.1 Lassopeptides: allorf_4061825_4061950_lassopeptide NZ_CP020352.1 Lassopeptides: allorf_4018279_4018404_lassopeptide NZ_CP023168.1 Lassopeptides: allorf_4201459_4201584_lassopeptide NZ_CP023665.1 Lassopeptides: allorf_4068832_4068957_lassopeptide NZ_CP033218.1 Lassopeptides: allorf_1613585_1613710_lassopeptide NZ_CP043761.1 Lassopeptides: allorf_6525412_6525540_lassopeptide NZ_CP049698.1 Lassopeptides: allorf_4058516_4058641_lassopeptide NZ_CP059494.1 Lassopeptides: allorf_3371934_3372059_lassopeptide NZ_CP068988.1 Lassopeptides: allorf_4020830_4020955_lassopeptide NZ_CP081825.1 Lassopeptides: allorf_1252758_1252886_lassopeptide NZ_CP083398.1 Lassopeptides: allorf_3088741_3088866_lassopeptide NZ_CP084682.1 Lassopeptides: allorf_4045630_4045755_lassopeptide NZ_CP090312.1 Lassopeptides: allorf_3988101_3988226_lassopeptide NZ_CP104093.1 Lassopeptides: allorf_0574703_0574828_lassopeptide NZ_CP110812.1 Lassopeptides: allorf_3160612_3160737_lassopeptide NZ_CP118744.1 Lassopeptides: allorf_4016420_4016545_lassopeptide NZ_JADNAZ010000003.1 Lassopeptides: allorf_147947_148072_lassopeptide NZ_JADNPI010000003.1 Lassopeptides: allorf_0346926_0347051_lassopeptide NZ_JAGTPZ010000028.1 Lassopeptides: allorf_0719212_0719337_lassopeptide NZ_JAHHXA010000001.1 Lassopeptides: allorf_234114_234239_lassopeptide NZ_JAJBZU010000003.1 Lassopeptides: allorf_0292203_0292328_lassopeptide NZ_JALAJD010000002.1 Lassopeptides: allorf_0333462_0333587_lassopeptide NZ_JALAJH010000002.1 Lassopeptides: allorf_205621_205746_lassopeptide NZ_JALAJI010000002.1 Lassopeptides: allorf_0713530_0713655_lassopeptide NZ_JALAJZ010000001.1 Lassopeptides: allorf_0700787_0700912_lassopeptide NZ_JALAKS010000001.1 Lassopeptides: allorf_053591_053716_lassopeptide NZ_JALALK010000001.1 Lassopeptides: allorf_0710239_0710364_lassopeptide NZ_JALALL010000012.1 Lassopeptides: allorf_159124_159249_lassopeptide NZ_JALALM010000005.1 Lassopeptides: allorf_0698852_0698977_lassopeptide NZ_JALALQ010000004.1 Lassopeptides: allorf_333021_333146_lassopeptide NZ_JALALU010000006.1 Lassopeptides: allorf_0339208_0339333_lassopeptide NZ_JALALZ010000002.1 Lassopeptides: allorf_0332050_0332175_lassopeptide NZ_JALAMC010000001.1 Lassopeptides: allorf_332573_332698_lassopeptide NZ_JALANK010000004.1 Lassopeptides: allorf_410616_410741_lassopeptide NZ_JALANL010000002.1 Lassopeptides: allorf_093009_093134_lassopeptide NZ_JALANM010000001.1 Lassopeptides: allorf_0332993_0333118_lassopeptide NZ_JALANO010000004.1 Lassopeptides: allorf_0347095_0347220_lassopeptide NZ_JALAON010000001.1 Lassopeptides: allorf_379211_379336_lassopeptide NZ_JALAOO010000003.1 Lassopeptides: allorf_069214_069339_lassopeptide NZ_JALAOQ010000004.1 Lassopeptides: allorf_0338021_0338146_lassopeptide NZ_JALAQL010000007.1 Lassopeptides: allorf_229865_229990_lassopeptide NZ_JALARN010000003.1 Lassopeptides: allorf_0700523_0700648_lassopeptide NZ_JALARO010000006.1 Lassopeptides: allorf_233062_233187_lassopeptide NZ_JALASJ010000005.1 Lassopeptides: allorf_0313268_0313393_lassopeptide NZ_JALAXE010000001.1 Lassopeptides: allorf_336072_336197_lassopeptide NZ_JALAXI010000010.1 Lassopeptides: allorf_327187_327312_lassopeptide NZ_JALAXO010000001.1 Lassopeptides: allorf_345480_345605_lassopeptide NZ_JALAXW010000003.1 Lassopeptides: allorf_0337796_0337921_lassopeptide NZ_JALAYB010000003.1 Lassopeptides: allorf_0339260_0339385_lassopeptide NZ_JALAYQ010000005.1 Lassopeptides: allorf_0332651_0332776_lassopeptide NZ_JALAYR010000003.1 Lassopeptides: allorf_0325317_0325442_lassopeptide NZ_JALHKQ010000002.1 Lassopeptides: allorf_0338015_0338140_lassopeptide NZ_KE819960.1 Lassopeptides: allorf_0718627_0718752_lassopeptide NZ_KN125579.1 Lassopeptides: allorf_1553823_1553948_lassopeptide NZ_LQYL01000021.1 Lassopeptides: allorf_340516_340641_lassopeptide NZ_MRBL01000001.1 Lassopeptides: allorf_147911_148036_lassopeptide NZ_MUEI01000002.1 Lassopeptides: allorf_0340674_0340799_lassopeptide NZ_NIJN01000012.1 Lassopeptides: allorf_433741_433866_lassopeptide NZ_NIKH01000013.1 Lassopeptides: allorf_0336426_0336551_lassopeptide NZ_NIKK01000036.1 Lassopeptides: allorf_265538_265663_lassopeptide NZ_NIKT01000037.1 Lassopeptides: allorf_071185_071310_lassopeptide NZ_NIKU01000018.1 Lassopeptides: allorf_0720911_0721036_lassopeptide NZ_NILF01000062.1 Lassopeptides: allorf_345658_345783_lassopeptide NZ_NIMP01000016.1 Lassopeptides: allorf_052906_053031_lassopeptide NZ_NKBC01000013.1 Lassopeptides: allorf_192723_192848_lassopeptide NZ_QXII01000003.1 Lassopeptides: allorf_0338451_0338576_lassopeptide NZ_RSBH01000002.1 Lassopeptides: allorf_192912_193037_lassopeptide NZ_RZIR01000001.1 Lassopeptides: allorf_4050643_4050768_lassopeptide
Lassopeptides: allorf_3863359_3863484_lassopeptide
1
A K S G K P G D G K H G K G-K R G
17
+K K P G D G K G+G K R G
1
S K K S K P G D G K F G R G V K R G
18
52.4%
NZ_CP023481.1 and 1 other:
NZ_JAQCPU010000002.1 Lassopeptides: allorf_328794_328907_lassopeptide
Lassopeptides: allorf_2680773_2680886_lassopeptide
1
A K S G K P G D G K H G K G K R G
17
+K K P G D G K G+G K+G
1
S K K S K P G D G K F G R G K K G
17
with 2 more sequence matches
47.6%
NZ_CP036072.1 and 20 others:
NZ_CP036072.1 Lassopeptides: allorf_073148_073267_lassopeptide NZ_CP036072.1 Lassopeptides: allorf_072992_073111_lassopeptide NZ_CP036072.1 Lassopeptides: allorf_072788_072955_lassopeptide NZ_FMBE01000014.1 Lassopeptides: allorf_124981_125100_lassopeptide NZ_FMBE01000014.1 Lassopeptides: allorf_124825_124944_lassopeptide NZ_FMBE01000014.1 Lassopeptides: allorf_124621_124788_lassopeptide NZ_FMBH01000039.1 Lassopeptides: allorf_21278_21445_lassopeptide NZ_FMBH01000039.1 Lassopeptides: allorf_21122_21241_lassopeptide NZ_FMBH01000039.1 Lassopeptides: allorf_20966_21085_lassopeptide NZ_KB976981.1 Lassopeptides: allorf_264123_264242_lassopeptide NZ_LDJQ01000026.1 Lassopeptides: allorf_16627_16794_lassopeptide NZ_LDJQ01000026.1 Lassopeptides: allorf_16471_16590_lassopeptide NZ_LDJQ01000026.1 Lassopeptides: allorf_16315_16434_lassopeptide NZ_NVLX01000026.1 Lassopeptides: allorf_29907_30074_lassopeptide NZ_NVLX01000026.1 Lassopeptides: allorf_29752_29871_lassopeptide NZ_NVLX01000026.1 Lassopeptides: allorf_29596_29715_lassopeptide NZ_VEFJ01000007.1 Lassopeptides: allorf_022530_022649_lassopeptide NZ_VEFJ01000007.1 Lassopeptides: allorf_022374_022493_lassopeptide NZ_VEFJ01000007.1 Lassopeptides: allorf_022171_022338_lassopeptide NZ_VEJP01000004.1 Lassopeptides: allorf_148376_148543_lassopeptide
Lassopeptides: allorf_073304_073423_lassopeptide
1
A K S G K P G D G K H G K G K R
16
A K K P G D G K G R
1
A K K N K P G D G T R T K G I R
16
47.6%
NZ_CP036072.1 and 6 others:
NZ_FMBE01000014.1 Lassopeptides: allorf_125136_125252_lassopeptide NZ_FMBH01000039.1 Lassopeptides: allorf_20814_20930_lassopeptide NZ_KB976981.1 Lassopeptides: allorf_264278_264394_lassopeptide NZ_LDJQ01000026.1 Lassopeptides: allorf_16163_16279_lassopeptide NZ_NVLX01000026.1 Lassopeptides: allorf_29444_29560_lassopeptide NZ_VEJP01000004.1 Lassopeptides: allorf_148224_148340_lassopeptide
Lassopeptides: allorf_073459_073575_lassopeptide
1
A K S G K P G D G K H G K G K R
16
A K+ K P G D G K G R
1
A K T K K P G D G T R A K G V R
16

#### MIBiG 4.0 matches for COE07_RS28155

52.4%
BGC0002150.2 (MBO0654592.1):
Lasso peptide: triculamin
1
A K S G K P G D G K H G K G K R G
17
+K K P G D G G K G R G
1
S K K S K P G D G I R G K G V R G
17

#### Lassopeptide(s) for COE07_RS28160

COE07_RS28160
Leader:
MKLTVGKVKEYGTFMNLTL
Full core:
A K S G K P G D G K H G K G K R G M K K A
Putative macrolactam:
A K S G K P G D

#### antiSMASH-DB 4.0 matches for COE07_RS28160

100.0%
NZ_NBBB01000032.1 and 3 others:
NZ_NBBB01000032.1 Lassopeptides: allorf_05793_05924_lassopeptide NZ_NUOG01000005.1 Lassopeptides: COE07_RS28160_lassopeptide NZ_NUOG01000005.1 Lassopeptides: COE07_RS28155_lassopeptide
Lassopeptides: allorf_06132_06263_lassopeptide
1
A K S G K P G D G K H G K G K R G M K K A
21
A K S G K P G D G K H G K G K R G M K K A
1
A K S G K P G D G K H G K G K R G M K K A
21
57.1%
NC_006322.1 and 72 others:
NC_021362.1 Lassopeptides: allorf_4042225_4042350_lassopeptide NZ_AP023088.1 Lassopeptides: allorf_0594187_0594312_lassopeptide NZ_AP025342.1 Lassopeptides: allorf_0961070_0961195_lassopeptide NZ_CABJBE010000002.1 Lassopeptides: allorf_334120_334245_lassopeptide NZ_CP010524.1 Lassopeptides: allorf_4061825_4061950_lassopeptide NZ_CP020352.1 Lassopeptides: allorf_4018279_4018404_lassopeptide NZ_CP023168.1 Lassopeptides: allorf_4201459_4201584_lassopeptide NZ_CP023665.1 Lassopeptides: allorf_4068832_4068957_lassopeptide NZ_CP033218.1 Lassopeptides: allorf_1613585_1613710_lassopeptide NZ_CP043761.1 Lassopeptides: allorf_6525412_6525540_lassopeptide NZ_CP049698.1 Lassopeptides: allorf_4058516_4058641_lassopeptide NZ_CP059494.1 Lassopeptides: allorf_3371934_3372059_lassopeptide NZ_CP068988.1 Lassopeptides: allorf_4020830_4020955_lassopeptide NZ_CP081825.1 Lassopeptides: allorf_1252758_1252886_lassopeptide NZ_CP083398.1 Lassopeptides: allorf_3088741_3088866_lassopeptide NZ_CP084682.1 Lassopeptides: allorf_4045630_4045755_lassopeptide NZ_CP090312.1 Lassopeptides: allorf_3988101_3988226_lassopeptide NZ_CP104093.1 Lassopeptides: allorf_0574703_0574828_lassopeptide NZ_CP110812.1 Lassopeptides: allorf_3160612_3160737_lassopeptide NZ_CP118744.1 Lassopeptides: allorf_4016420_4016545_lassopeptide NZ_JADNAZ010000003.1 Lassopeptides: allorf_147947_148072_lassopeptide NZ_JADNPI010000003.1 Lassopeptides: allorf_0346926_0347051_lassopeptide NZ_JAGTPZ010000028.1 Lassopeptides: allorf_0719212_0719337_lassopeptide NZ_JAHHXA010000001.1 Lassopeptides: allorf_234114_234239_lassopeptide NZ_JAJBZU010000003.1 Lassopeptides: allorf_0292203_0292328_lassopeptide NZ_JALAJD010000002.1 Lassopeptides: allorf_0333462_0333587_lassopeptide NZ_JALAJH010000002.1 Lassopeptides: allorf_205621_205746_lassopeptide NZ_JALAJI010000002.1 Lassopeptides: allorf_0713530_0713655_lassopeptide NZ_JALAJZ010000001.1 Lassopeptides: allorf_0700787_0700912_lassopeptide NZ_JALAKS010000001.1 Lassopeptides: allorf_053591_053716_lassopeptide NZ_JALALK010000001.1 Lassopeptides: allorf_0710239_0710364_lassopeptide NZ_JALALL010000012.1 Lassopeptides: allorf_159124_159249_lassopeptide NZ_JALALM010000005.1 Lassopeptides: allorf_0698852_0698977_lassopeptide NZ_JALALQ010000004.1 Lassopeptides: allorf_333021_333146_lassopeptide NZ_JALALU010000006.1 Lassopeptides: allorf_0339208_0339333_lassopeptide NZ_JALALZ010000002.1 Lassopeptides: allorf_0332050_0332175_lassopeptide NZ_JALAMC010000001.1 Lassopeptides: allorf_332573_332698_lassopeptide NZ_JALANK010000004.1 Lassopeptides: allorf_410616_410741_lassopeptide NZ_JALANL010000002.1 Lassopeptides: allorf_093009_093134_lassopeptide NZ_JALANM010000001.1 Lassopeptides: allorf_0332993_0333118_lassopeptide NZ_JALANO010000004.1 Lassopeptides: allorf_0347095_0347220_lassopeptide NZ_JALAON010000001.1 Lassopeptides: allorf_379211_379336_lassopeptide NZ_JALAOO010000003.1 Lassopeptides: allorf_069214_069339_lassopeptide NZ_JALAOQ010000004.1 Lassopeptides: allorf_0338021_0338146_lassopeptide NZ_JALAQL010000007.1 Lassopeptides: allorf_229865_229990_lassopeptide NZ_JALARN010000003.1 Lassopeptides: allorf_0700523_0700648_lassopeptide NZ_JALARO010000006.1 Lassopeptides: allorf_233062_233187_lassopeptide NZ_JALASJ010000005.1 Lassopeptides: allorf_0313268_0313393_lassopeptide NZ_JALAXE010000001.1 Lassopeptides: allorf_336072_336197_lassopeptide NZ_JALAXI010000010.1 Lassopeptides: allorf_327187_327312_lassopeptide NZ_JALAXO010000001.1 Lassopeptides: allorf_345480_345605_lassopeptide NZ_JALAXW010000003.1 Lassopeptides: allorf_0337796_0337921_lassopeptide NZ_JALAYB010000003.1 Lassopeptides: allorf_0339260_0339385_lassopeptide NZ_JALAYQ010000005.1 Lassopeptides: allorf_0332651_0332776_lassopeptide NZ_JALAYR010000003.1 Lassopeptides: allorf_0325317_0325442_lassopeptide NZ_JALHKQ010000002.1 Lassopeptides: allorf_0338015_0338140_lassopeptide NZ_KE819960.1 Lassopeptides: allorf_0718627_0718752_lassopeptide NZ_KN125579.1 Lassopeptides: allorf_1553823_1553948_lassopeptide NZ_LQYL01000021.1 Lassopeptides: allorf_340516_340641_lassopeptide NZ_MRBL01000001.1 Lassopeptides: allorf_147911_148036_lassopeptide NZ_MUEI01000002.1 Lassopeptides: allorf_0340674_0340799_lassopeptide NZ_NIJN01000012.1 Lassopeptides: allorf_433741_433866_lassopeptide NZ_NIKH01000013.1 Lassopeptides: allorf_0336426_0336551_lassopeptide NZ_NIKK01000036.1 Lassopeptides: allorf_265538_265663_lassopeptide NZ_NIKT01000037.1 Lassopeptides: allorf_071185_071310_lassopeptide NZ_NIKU01000018.1 Lassopeptides: allorf_0720911_0721036_lassopeptide NZ_NILF01000062.1 Lassopeptides: allorf_345658_345783_lassopeptide NZ_NIMP01000016.1 Lassopeptides: allorf_052906_053031_lassopeptide NZ_NKBC01000013.1 Lassopeptides: allorf_192723_192848_lassopeptide NZ_QXII01000003.1 Lassopeptides: allorf_0338451_0338576_lassopeptide NZ_RSBH01000002.1 Lassopeptides: allorf_192912_193037_lassopeptide NZ_RZIR01000001.1 Lassopeptides: allorf_4050643_4050768_lassopeptide
Lassopeptides: allorf_3863359_3863484_lassopeptide
1
A K S G K P G D G K H G K G-K R G
17
+K K P G D G K G+G K R G
1
S K K S K P G D G K F G R G V K R G
18
52.4%
NZ_CP023481.1 and 1 other:
NZ_JAQCPU010000002.1 Lassopeptides: allorf_328794_328907_lassopeptide
Lassopeptides: allorf_2680773_2680886_lassopeptide
1
A K S G K P G D G K H G K G K R G
17
+K K P G D G K G+G K+G
1
S K K S K P G D G K F G R G K K G
17
with 2 more sequence matches
47.6%
NZ_CP036072.1 and 20 others:
NZ_CP036072.1 Lassopeptides: allorf_073148_073267_lassopeptide NZ_CP036072.1 Lassopeptides: allorf_072992_073111_lassopeptide NZ_CP036072.1 Lassopeptides: allorf_072788_072955_lassopeptide NZ_FMBE01000014.1 Lassopeptides: allorf_124981_125100_lassopeptide NZ_FMBE01000014.1 Lassopeptides: allorf_124825_124944_lassopeptide NZ_FMBE01000014.1 Lassopeptides: allorf_124621_124788_lassopeptide NZ_FMBH01000039.1 Lassopeptides: allorf_21278_21445_lassopeptide NZ_FMBH01000039.1 Lassopeptides: allorf_21122_21241_lassopeptide NZ_FMBH01000039.1 Lassopeptides: allorf_20966_21085_lassopeptide NZ_KB976981.1 Lassopeptides: allorf_264123_264242_lassopeptide NZ_LDJQ01000026.1 Lassopeptides: allorf_16627_16794_lassopeptide NZ_LDJQ01000026.1 Lassopeptides: allorf_16471_16590_lassopeptide NZ_LDJQ01000026.1 Lassopeptides: allorf_16315_16434_lassopeptide NZ_NVLX01000026.1 Lassopeptides: allorf_29907_30074_lassopeptide NZ_NVLX01000026.1 Lassopeptides: allorf_29752_29871_lassopeptide NZ_NVLX01000026.1 Lassopeptides: allorf_29596_29715_lassopeptide NZ_VEFJ01000007.1 Lassopeptides: allorf_022530_022649_lassopeptide NZ_VEFJ01000007.1 Lassopeptides: allorf_022374_022493_lassopeptide NZ_VEFJ01000007.1 Lassopeptides: allorf_022171_022338_lassopeptide NZ_VEJP01000004.1 Lassopeptides: allorf_148376_148543_lassopeptide
Lassopeptides: allorf_073304_073423_lassopeptide
1
A K S G K P G D G K H G K G K R
16
A K K P G D G K G R
1
A K K N K P G D G T R T K G I R
16
47.6%
NZ_CP036072.1 and 6 others:
NZ_FMBE01000014.1 Lassopeptides: allorf_125136_125252_lassopeptide NZ_FMBH01000039.1 Lassopeptides: allorf_20814_20930_lassopeptide NZ_KB976981.1 Lassopeptides: allorf_264278_264394_lassopeptide NZ_LDJQ01000026.1 Lassopeptides: allorf_16163_16279_lassopeptide NZ_NVLX01000026.1 Lassopeptides: allorf_29444_29560_lassopeptide NZ_VEJP01000004.1 Lassopeptides: allorf_148224_148340_lassopeptide
Lassopeptides: allorf_073459_073575_lassopeptide
1
A K S G K P G D G K H G K G K R
16
A K+ K P G D G K G R
1
A K T K K P G D G T R A K G V R
16

#### MIBiG 4.0 matches for COE07_RS28160

52.4%
BGC0002150.2 (MBO0654592.1):
Lasso peptide: triculamin
1
A K S G K P G D G K H G K G K R G
17
+K K P G D G G K G R G
1
S K K S K P G D G I R G K G V R G
17

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
No hits above weak threshold.
Weak hits (5):
DosR
Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 19.76 out of 29.51
Confidence: weak
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.27 out of 25.75
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.85 out of 33.14
Confidence: weak
CsoR
Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 19.72 out of 32.38
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.79 out of 33.14
Confidence: weak
Lasso peptides
RREFinder
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of disulfide bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

COE07_RS28155 - Class II
  Cleavage pHMM score: -5.20
  RODEO score: 17
  Monoisotopic mass: 2104.2 Da
  Molecular weight: 2105.5 Da
  Number of bridges: 0
COE07_RS28160 - Class II
  Cleavage pHMM score: -5.20
  RODEO score: 16
  Monoisotopic mass: 2104.2 Da
  Molecular weight: 2105.5 Da
  Number of bridges: 0

RRE predictions
RREfinder results sidepanel.

lassopeptide protocluster (3848...26573)
COE07_RS01805
  RRE type: Stand_Alone_Lasso_RRE
  Location: 1 - 86
  Score: 34.6

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
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