GCF_002163735.1 - 7 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP015883.1 (Enterococcus faecalis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1.1	lanthipeptide-class-ii	200,141	223,122	High	cytolysin ClyLl/cytolysin ClyLs	ribosomal:RiPP:Lanthipeptide
Region 1.2	arylpolyene,NRPS	514,732	558,602
Region 1.3	terpene-precursor	889,652	910,533
Region 1.4	RRE-containing	1,250,765	1,271,898
Region 1.5	cyclic-lactone-autoinducer	1,674,786	1,695,514

NZ_CP015884.1 (Enterococcus faecalis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 2.1	RiPP-like	114,557	124,703

NZ_CP015885.1 (Enterococcus faecalis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 3.1	RiPP-like	37,487	49,637	Low	carnobacteriocin XY	ribosomal:RiPP

Compact view

NZ_CP015883.1 - Region 1 - lanthipeptide-class-ii

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Location: 200,141 - 223,122 nt. (total: 22,982 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

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Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: protease

A6B47_RS00860: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase

A6B47_RS00870: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.96	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000500.5	0.53	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000623.3	0.49	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001407.5	0.48	ribosomal	bicereucin	Bacillus cereus SJ1
BGC0000516.4	0.47	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0002698.2	0.47	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0002674.2	0.46	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0001210.5	0.45	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000502.5	0.45	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0001862.4	0.44	ribosomal	pallidocin	Aeribacillus pallidus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000504.5	0.96	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000500.5	0.53	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000623.3	0.49	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001407.5	0.48	ribosomal	bicereucin	Bacillus cereus SJ1
BGC0000516.4	0.47	ribosomal	geobacillin II	Geobacillus thermodenitrificans
BGC0002698.2	0.47	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0002674.2	0.46	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0001210.5	0.45	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000502.5	0.45	ribosomal	cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7	Bacillus cereus
BGC0001862.4	0.44	ribosomal	pallidocin	Aeribacillus pallidus

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for A6B47_RS00870

A6B47_RS00875

Leader:

MLNKENQENYYSNKLELVGPSFEELSLEEMEAIQGS

Core:

GDVQAETTPACFTIGLGVGALFSAKFC

Core with dehydrations:

GDVQAEDhbDhbPACysFDhbIGLGVGALFDhaAKFCys

antiSMASH-DB 4.0 matches for A6B47_RS00875

100.0%

NZ_AP026721.1and 35 others:

NZ_CP015883.1 Lanthipeptides: A6B47_RS00875_lanthipeptideNZ_CP028286.1 Lanthipeptides: CEQ02_RS16115_lanthipeptideNZ_CP028721.1 Lanthipeptides: C7I32_RS15475_lanthipeptideNZ_CP028835.1 Lanthipeptides: C9432_RS02740_lanthipeptideNZ_CP028837.1 Lanthipeptides: C9432_RS15935_lanthipeptideNZ_CP033787.1 Lanthipeptides: EGX75_RS02740_lanthipeptideNZ_CP039296.1 Lanthipeptides: E7T02_RS02755_lanthipeptideNZ_CP045045.1 Lanthipeptides: F9293_RS12755_lanthipeptideNZ_CP075604.2 Lanthipeptides: KKP64_RS02155_lanthipeptideNZ_CP085289.1 Lanthipeptides: LIT95_RS07630_lanthipeptideNZ_CP085291.1 Lanthipeptides: LIT96_RS04335_lanthipeptideNZ_CP085297.1 Lanthipeptides: LIT97_RS14520_lanthipeptideNZ_CP086726.1 Lanthipeptides: LM507_RS03415_lanthipeptideNZ_CP091901.1 Lanthipeptides: L5I17_RS09010_lanthipeptideNZ_CP091905.1 Lanthipeptides: L5I20_RS14940_lanthipeptideNZ_CP091907.1 Lanthipeptides: L5I26_RS13265_lanthipeptideNZ_CP093957.1 Lanthipeptides: MPM64_RS01385_lanthipeptideNZ_CP116962.1 Lanthipeptides: PO880_RS13030_lanthipeptideNZ_JAASJP010000011.1 Lanthipeptides: HCH27_RS13275_lanthipeptideNZ_JAHZNN010000041.1 Lanthipeptides: K0X81_RS16410_lanthipeptideNZ_JAKTAU010000028.1 Lanthipeptides: MKK46_RS14535_lanthipeptideNZ_JALSCL010000035.1 Lanthipeptides: NEI30_RS13375_lanthipeptideNZ_JAQDOF010000024.1 Lanthipeptides: PGP79_RS14595_lanthipeptideNZ_JAQKZU010000014.1 Lanthipeptides: PMV60_RS12615_lanthipeptideNZ_KB932317.1 Lanthipeptides: Q95_RS09840_lanthipeptideNZ_KB932336.1 Lanthipeptides: Q9C_RS13350_lanthipeptideNZ_KB944697.1 Lanthipeptides: WO3_RS18030_lanthipeptideNZ_KB944708.1 Lanthipeptides: WO5_RS05650_lanthipeptideNZ_KB944753.1 Lanthipeptides: WO9_RS06460_lanthipeptideNZ_KB944762.1 Lanthipeptides: WOA_RS17470_lanthipeptideNZ_KB944819.1 Lanthipeptides: WOK_RS14355_lanthipeptideNZ_KB946767.1 Lanthipeptides: UK1_RS12990_lanthipeptideNZ_KB947483.1 Lanthipeptides: WUI_RS10440_lanthipeptideNZ_KZ845881.1 Lanthipeptides: EB41_RS04380_lanthipeptideNZ_NGMY01000001.1 Lanthipeptides: A5862_RS02370_lanthipeptide

Lanthipeptides: PO855_RS02215_lanthipeptide

1

GDVQAETTPACFTIGLGVGALFSAKFC

27

GDVQAETTPACFTIGLGVGALFSAKFC

1

GDVQAETTPACFTIGLGVGALFSAKFC

27

85.2%

NZ_CP011974.1and 2 others:

NZ_CP115914.1 Lanthipeptides: PGN40_RS02040_lanthipeptideNZ_MWSI01000006.1 Lanthipeptides: B1B01_RS20140_lanthipeptide

Lanthipeptides: BEH_RS02100_lanthipeptide

1

GDVQAETTPACFTIGLGVGALFSAKFC

27

GDVQAETTP CFTIGLGVGAL SA C

1

GDVQAETTPVCFTIGLGVGALVSAAGC

27

77.8%

NZ_JH791802.1and 2 others:

NZ_MIFM01000001.1 Lanthipeptides: BHL22_RS00410_lanthipeptideNZ_NINI01000009.1 Lanthipeptides: CEV12_RS07260_lanthipeptide

Lanthipeptides: IKS_RS03655_lanthipeptide

1

GDVQAETTPACFTIGLGVGALFSAKFC

27

GDVQAETTP CFT+GLGVG+L SA C

1

GDVQAETTPVCFTVGLGVGSLVSASVC

27

with 108 more sequence matches

Only the first 10 are displayed here.

74.1%

NZ_JH791802.1and 2 others:

NZ_MIFM01000001.1 Lanthipeptides: BHL22_RS00405_lanthipeptideNZ_NINI01000009.1 Lanthipeptides: CEV12_RS07255_lanthipeptide

Lanthipeptides: IKS_RS03660_lanthipeptide

1

GDVQAETTPACFTIGLGVGALFSAKFC

27

GDVQAETTP CFT+GLG+G+L SA C

1

GDVQAETTPVCFTVGLGIGSLVSASVC

27

71.4%

NZ_KB946334.1:

Lanthipeptides: UC7_RS10230_lanthipeptide

1

GDVQAETTPAC-FTIGLGVGALFSAKFC

27

GDVQ ETTP C FTIG+G+GAL S K+C

1

GDVQPETTPICGFTIGIGIGALASVKWC

28

71.4%

NZ_KB946334.1:

Lanthipeptides: UC7_RS10250_lanthipeptide

1

GDVQAETTPAC-FTIGLGVGALFSAKFC

27

GDVQ ETTP C FTIG+G+GAL S K+C

1

GDVQPETTPLCGFTIGIGIGALVSVKWC

28

70.0%

NZ_NVAW01000030.1and 1 other:

NZ_NVEP01000021.1 Lanthipeptides: COL17_RS24445_lanthipeptide

Lanthipeptides: COK11_RS25885_lanthipeptide

1

GDVQAETTPAC---FTIGLGVGALFSAKFC

27

GDV+ ETTPAC FTIGLG+GAL SA C

1

GDVKPETTPACLAGFTIGLGIGALASAAGC

30

66.7%

NZ_CP025701.1:

Lanthipeptides: C0569_RS26125_lanthipeptide

1

GDVQAETTPAC---FTIGLGVGALFSAKFC

27

GDV+ ETTPAC FT+GLG+GAL SA C

1

GDVKPETTPACLAGFTVGLGIGALASAAGC

30

63.0%

NZ_JACDUU010000003.1:

Lanthipeptides: HNQ85_RS08035_lanthipeptide

1

GDVQAETTPACFTIGLGVGALFSAKFC

27

GDVQ ET+PAC TIG+G+G S FC

1

GDVQPETSPACVTIGIGIGIGISKLFC

27

59.3%

NZ_JAOVZP010000016.1and 3 others:

NZ_NHVL01000036.1 Lanthipeptides: CEU70_RS27720_lanthipeptideNZ_NTYE01000081.1 Lanthipeptides: CN490_RS28165_lanthipeptideNZ_NVMN01000027.1 Lanthipeptides: CON30_RS23205_lanthipeptide

Lanthipeptides: OF830_RS26725_lanthipeptide

1

GDVQAETTPACFTIGLGVGALFSAKFC

27

DVQ ETTPAC T L G +FS K+C

1

SDVQPETTPACVT-ALTTGIIFSIKWC

26

58.6%

NZ_JAOVZP010000016.1and 3 others:

NZ_NHVL01000036.1 Lanthipeptides: CEU70_RS27725_lanthipeptideNZ_NTYE01000081.1 Lanthipeptides: CN490_RS28170_lanthipeptideNZ_NVMN01000027.1 Lanthipeptides: CON30_RS23200_lanthipeptide

Lanthipeptides: OF830_RS26730_lanthipeptide

1

GDVQAETTPAC---FTIGLGVGALFSAKFC

27

DVQ ETTPAC FTIG V +FS + C

1

SDVQPETTPACAVAFTIGATV--IFSVRNC

28

57.1%

NZ_JANFNS010000003.1:

Lanthipeptides: NOM90_RS11325_lanthipeptide

2

DVQAETTPAC-FTIGLGVGALFSAKFC

27

DVQ ETTP C F +G+G+GA+ SA C

2

DVQPETTPVCGFFVGVGIGAIISATAC

28

55.6%

NZ_JACSPU010000002.1:

Lanthipeptides: H9630_RS06775_lanthipeptide

1

GDVQAETTPACFTIGLGVGALFSAKFC

27

DV ETTPAC G LFS KFC

1

SDVAPETTPAC-VAAFATGLLFSIKFC

26

MIBiG 4.0 matches for A6B47_RS00875

27.0%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

7

TTPACFTIGLGVGAL-------FSAKFC

27

T PA + LG+ A+ SA FC

1

TDPAVTGLILGIVAIQAGVAVGVSAAFC

28

11.8%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

8

TPACFT

13

TP C T

8

TPGCKT

13

7.8%

BGC0002120.3 (NQE92413.1):

Lanthipeptide: nocathioamide A

9

PACFTIG

15

PAC T+

38

PACHTLS

44

A6B47_RS00880

Leader:

MENLNVVPSFEELSVEEMEAIQGS

Core:

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

Core with dehydrations:

GDVQAEDhbDhbPVCysAVAADhbAAADhaDhaAACysGWVGGGIFDhbGVDhbVVVDhaLKHCys

antiSMASH-DB 4.0 matches for A6B47_RS00880

100.0%

NZ_AP026721.1and 34 others:

NZ_CP015883.1 Lanthipeptides: A6B47_RS00880_lanthipeptideNZ_CP028286.1 Lanthipeptides: CEQ02_RS16120_lanthipeptideNZ_CP028721.1 Lanthipeptides: C7I32_RS15480_lanthipeptideNZ_CP028835.1 Lanthipeptides: C9432_RS02735_lanthipeptideNZ_CP028837.1 Lanthipeptides: C9432_RS15930_lanthipeptideNZ_CP033787.1 Lanthipeptides: EGX75_RS02745_lanthipeptideNZ_CP039296.1 Lanthipeptides: E7T02_RS02750_lanthipeptideNZ_CP045045.1 Lanthipeptides: F9293_RS12760_lanthipeptideNZ_CP075604.2 Lanthipeptides: KKP64_RS02150_lanthipeptideNZ_CP085289.1 Lanthipeptides: LIT95_RS07625_lanthipeptideNZ_CP085291.1 Lanthipeptides: LIT96_RS04340_lanthipeptideNZ_CP085297.1 Lanthipeptides: LIT97_RS14515_lanthipeptideNZ_CP086726.1 Lanthipeptides: LM507_RS03420_lanthipeptideNZ_CP091901.1 Lanthipeptides: L5I17_RS09015_lanthipeptideNZ_CP091905.1 Lanthipeptides: L5I20_RS14935_lanthipeptideNZ_CP091907.1 Lanthipeptides: L5I26_RS13260_lanthipeptideNZ_CP093957.1 Lanthipeptides: MPM64_RS01390_lanthipeptideNZ_CP116962.1 Lanthipeptides: PO880_RS13035_lanthipeptideNZ_JAASJP010000011.1 Lanthipeptides: HCH27_RS13280_lanthipeptideNZ_JAHZNN010000041.1 Lanthipeptides: K0X81_RS16405_lanthipeptideNZ_JAKTAU010000028.1 Lanthipeptides: MKK46_RS14540_lanthipeptideNZ_JALSCL010000035.1 Lanthipeptides: NEI30_RS13380_lanthipeptideNZ_JAQDOF010000024.1 Lanthipeptides: PGP79_RS14600_lanthipeptideNZ_JAQKZU010000014.1 Lanthipeptides: PMV60_RS12620_lanthipeptideNZ_KB932317.1 Lanthipeptides: Q95_RS09835_lanthipeptideNZ_KB932336.1 Lanthipeptides: Q9C_RS13355_lanthipeptideNZ_KB944697.1 Lanthipeptides: WO3_RS18035_lanthipeptideNZ_KB944708.1 Lanthipeptides: WO5_RS05645_lanthipeptideNZ_KB944753.1 Lanthipeptides: WO9_RS06455_lanthipeptideNZ_KB944762.1 Lanthipeptides: WOA_RS17465_lanthipeptideNZ_KB944819.1 Lanthipeptides: WOK_RS14360_lanthipeptideNZ_KB946767.1 Lanthipeptides: UK1_RS12995_lanthipeptideNZ_KB947483.1 Lanthipeptides: WUI_RS10435_lanthipeptideNZ_KZ845881.1 Lanthipeptides: EB41_RS04385_lanthipeptide

Lanthipeptides: PO855_RS02210_lanthipeptide

1

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

44

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

1

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

44

93.2%

NZ_CP011974.1and 2 others:

NZ_CP115914.1 Lanthipeptides: PGN40_RS02045_lanthipeptideNZ_MWSI01000006.1 Lanthipeptides: B1B01_RS20135_lanthipeptide

Lanthipeptides: BEH_RS02105_lanthipeptide

1

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

44

GDVQAETTPVCA+AATAAASSAACG+VGGGIFTGVTVVVSLK C

1

GDVQAETTPVCAIAATAAASSAACGYVGGGIFTGVTVVVSLKSC

44

90.9%

NZ_CP011974.1and 2 others:

NZ_CP115914.1 Lanthipeptides: PGN40_RS02050_lanthipeptideNZ_MWSI01000006.1 Lanthipeptides: B1B01_RS20130_lanthipeptide

Lanthipeptides: BEH_RS02110_lanthipeptide

1

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

44

GDVQAETTPVCA+AATAAASSAACG+VGGGIFTGVTVVV+LK C

1

GDVQAETTPVCAIAATAAASSAACGYVGGGIFTGVTVVVTLKSC

44

with 107 more sequence matches

Only the first 10 are displayed here.

86.4%

NZ_JH791802.1and 5 others:

NZ_MIFM01000001.1 Lanthipeptides: BHL22_RS00420_lanthipeptideNZ_MIFM01000001.1 Lanthipeptides: BHL22_RS00415_lanthipeptideNZ_NINI01000009.1 Lanthipeptides: CEV12_RS07275_lanthipeptideNZ_NINI01000009.1 Lanthipeptides: CEV12_RS07270_lanthipeptideNZ_NINI01000009.1 Lanthipeptides: CEV12_RS07265_lanthipeptide

Lanthipeptides: IKS_RS30065_lanthipeptide

1

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

44

GDVQAETTPVCA+AAT AASSAACGWVGGGI TGVTVV++LK C

1

GDVQAETTPVCAIAATTAASSAACGWVGGGIATGVTVVITLKSC

44

84.1%

NZ_CP025701.1:

Lanthipeptides: C0569_RS26130_lanthipeptide

1

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

44

GDVQAETTPVCA+AATAAASS C GGGI TGVTVVVSLKHC

1

GDVQAETTPVCAIAATAAASSGICAATGGGIATGVTVVVSLKHC

44

81.8%

NZ_NVAW01000030.1and 1 other:

NZ_NVEP01000021.1 Lanthipeptides: COL17_RS24440_lanthipeptide

Lanthipeptides: COK11_RS25880_lanthipeptide

1

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

44

GDVQAETTPVCAVAATAAASS C G GI TGVTVVVSLK C

1

GDVQAETTPVCAVAATAAASSGVCAATGAGIATGVTVVVSLKSC

44

77.3%

NZ_MIFM01000001.1and 1 other:

NZ_NINI01000009.1 Lanthipeptides: CEV12_RS07280_lanthipeptide

Lanthipeptides: BHL22_RS00425_lanthipeptide

1

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

44

GDVQAETTPVCAV+ SSAACGWV GGI TGVTVVV+LK C

1

GDVQAETTPVCAVSVATMTSSAACGWVAGGIATGVTVVVTLKSC

44

72.7%

NZ_CP062165.1and 5 others:

NZ_CP062165.1 Lanthipeptides: JNUCC31_RS17165_lanthipeptideNZ_QICW01000005.1 Lanthipeptides: DEU73_RS14625_lanthipeptideNZ_QICW01000005.1 Lanthipeptides: DEU73_RS14625_lanthipeptideNZ_QLLI01000007.1 Lanthipeptides: DET54_RS17330_lanthipeptideNZ_QLLI01000007.1 Lanthipeptides: DET54_RS17330_lanthipeptide

Lanthipeptides: JNUCC31_RS17165_lanthipeptide

1

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

44

GDVQ ETTPVCAVAAT AASSA C VGGGI GVT+V+++K C

1

GDVQPETTPVCAVAATVAASSATCAAVGGGIAVGVTIVLTIKSC

44

72.7%

NZ_JANFNS010000003.1:

Lanthipeptides: NOM90_RS11330_lanthipeptide

1

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

44

DVQ ETTPVCAVAAT AASSA C VGGG+ GVTVV++LK C

1

ADVQPETTPVCAVAATVAASSATCAAVGGGVAVGVTVVLTLKTC

44

70.5%

NZ_KB946334.1and 1 other:

NZ_KB946334.1 Lanthipeptides: UC7_RS10235_lanthipeptide

Lanthipeptides: UC7_RS10245_lanthipeptide

1

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

44

GDVQAETTPVCA++AT AASSAAC VG GI TG+T+V++ K C

1

GDVQAETTPVCAISATVAASSAACAGVGAGIGTGITIVLTFKRC

44

68.2%

NZ_KB946334.1:

Lanthipeptides: UC7_RS10240_lanthipeptide

1

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

44

GDVQ ETTPVCA++AT AASSAAC VG GI TG+T+V++ K C

1

GDVQVETTPVCAISATVAASSAACAGVGAGIGTGITIVLTFKRC

44

68.2%

NZ_LN831278.1:

Lanthipeptides: BN1360_RS08835_lanthipeptide

2

DVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

44

DVQ ETTP+CAVAAT AASSA C VGGGI GVT+V+++K C

2

DVQPETTPICAVAATVAASSATCAAVGGGIAVGVTIVLTIKSC

44

65.9%

NC_014098.1:

Lanthipeptides: BTUS_RS14190_lanthipeptide

1

GDVQAETTPVCAVAATAAASSAACGWVGGGIFTGVTVVVSLKHC

44

GDVQAETTP+C AAT ASSAAC VG GI GVT+V+++K C

1

GDVQAETTPICYTAATVTASSAACAGVGAGIVAGVTIVLTIKRC

44

A6B47_RS15575

Leader:

MKEIVVDNFAGG

Core:

GGASTGTEHAIGRSVDVAINHDPDAIAMHEANHPNTKHYCESVWESTREMLPMDGQ

Core with dehydrations:

GGADhaDhbGDhbEHAIGRDhaVDVAINHDPDAIAMHEANHPNDhbKHYCysEDhaVWEDhaDhbREMLPMDGQ

antiSMASH-DB 4.0 matches for A6B47_RS15575

100.0%

NZ_CP015883.1:

Lanthipeptides: A6B47_RS15575_lanthipeptide

1

GGASTGTEHAIGRSVDVAINHDPDAIAMHEANHPNTKHYCESVWESTREMLPMDGQ

56

GGASTGTEHAIGRSVDVAINHDPDAIAMHEANHPNTKHYCESVWESTREMLPMDGQ

1

GGASTGTEHAIGRSVDVAINHDPDAIAMHEANHPNTKHYCESVWESTREMLPMDGQ

56

16.1%

NZ_CP050504.1:

Lanthipeptides: allorf_0161193_0161369_lanthipeptide

1

GGASTGTEHAIGRSVDVAINH

21

G A G EH R D A+ H

12

GTACPGYEHCRARLRDDALLH

32

12.5%

NZ_CP020327.1:

Lanthipeptides: allorf_1389413_1389616_lanthipeptide

34

PNTKHYCESVWESTREMLP

52

P+ K C S +S+ LP

16

PSCKAVCSSACDSSTRFLP

34

with 2 more sequence matches

10.7%

NZ_AXVJ01000055.1and 3 others:

NZ_CP031030.1 Lanthipeptides: DTQ70_RS30930_lanthipeptideNZ_CP031030.1 Lanthipeptides: DTQ70_RS30935_lanthipeptideNZ_JACIBY010000001.1 Lanthipeptides: FHS57_RS00285_lanthipeptide

Lanthipeptides: K339_RS36965_lanthipeptide

32

NHPNTKHYCES

42

++P +KHYC S

9

SNPTSKHYCHS

19

7.1%

NZ_CP014326.1:

Lanthipeptides: AXK38_RS05515_lanthipeptide

38

HYCESVWESTREM

50

YC ++W R +

40

QYCTAIWGIARSL

52

allorf_0205278_0205448

Leader:

METAHLKIHFVKGLSNSFGK

Core:

NKNKNSTIKFVTASINNGCMWNTVFRNIYRCLTPYK

Core with dehydrations:

NKNKNDhaDhbIKFVDhbADhaINNGCysMWNDhbVFRNIYRCysLDhbPYK

antiSMASH-DB 4.0 matches for allorf_0205278_0205448

100.0%

NZ_CP015883.1and 1 other:

NZ_JAASJP010000011.1 Lanthipeptides: allorf_43013_43183_lanthipeptide

Lanthipeptides: allorf_0205278_0205448_lanthipeptide

1

NKNKNSTIKFVTASINNGCMWNTVFRNIYRCLTPYK

36

NKNKNSTIKFVTASINNGCMWNTVFRNIYRCLTPYK

1

NKNKNSTIKFVTASINNGCMWNTVFRNIYRCLTPYK

36

52.8%

NZ_CP091901.1and 5 others:

NZ_KB932317.1 Lanthipeptides: allorf_1274501_1274623_lanthipeptideNZ_KB944819.1 Lanthipeptides: allorf_0835577_0835699_lanthipeptideNZ_KB946767.1 Lanthipeptides: allorf_0873518_0873640_lanthipeptideNZ_KB946767.1 Lanthipeptides: allorf_0869748_0869870_lanthipeptideNZ_KZ845881.1 Lanthipeptides: allorf_0859524_0859646_lanthipeptide

Lanthipeptides: allorf_1827294_1827416_lanthipeptide

1

NKNKNSTIKFVTASINNGCM

20

NKNKNS IKFVTASINNGCM

1

NKNKNSMIKFVTASINNGCM

20

16.7%

NZ_BMSZ01000006.1:

Lanthipeptides: allorf_250966_251172_lanthipeptide

13

ASINNGCMWNTVFR

26

A+ +G +WN+ FR

1

AADGSGKVWNSTFR

14

with 2 more sequence matches

13.9%

NC_011071.1and 41 others:

NZ_AP021867.1 Lassopeptides: GJU96_RS20605_lassopeptideNZ_CP011010.1 Lassopeptides: VN11_RS22530_lassopeptideNZ_CP011305.1 Lassopeptides: YH67_RS21020_lassopeptideNZ_CP015612.1 Lassopeptides: A7326_RS21600_lassopeptideNZ_CP027562.1 Lassopeptides: C6Y55_RS23185_lassopeptideNZ_CP029773.1 Lassopeptides: DM611_RS22725_lassopeptideNZ_CP031058.1 Lassopeptides: DUW70_RS11975_lassopeptideNZ_CP031167.1 Lassopeptides: MG068_RS21080_lassopeptideNZ_CP037858.1 Lassopeptides: EZ304_RS20935_lassopeptideNZ_CP040432.1 Lassopeptides: FEO95_RS22840_lassopeptideNZ_CP040438.1 Lassopeptides: FEO89_RS21625_lassopeptideNZ_CP040439.1 Lassopeptides: FEO88_RS23220_lassopeptideNZ_CP043578.1 Lassopeptides: F0Q13_RS11365_lassopeptideNZ_CP046588.1 Lassopeptides: GOC52_RS10870_lassopeptideNZ_CP047310.1 Lassopeptides: GS396_RS20180_lassopeptideNZ_CP060259.1 Lassopeptides: H7F32_RS11180_lassopeptideNZ_CP067993.1 Lassopeptides: JJL50_RS10815_lassopeptideNZ_CP077679.1 Lassopeptides: KS456_RS10490_lassopeptideNZ_CP080573.1 Lassopeptides: K1516_RS11235_lassopeptideNZ_CP090418.1 Lassopeptides: LYZ64_RS11980_lassopeptideNZ_CP096975.1 Lassopeptides: M1L61_RS12085_lassopeptideNZ_CP104169.1 Lassopeptides: NDR96_RS09175_lassopeptideNZ_CP106759.1 Lassopeptides: N8888_RS09665_lassopeptideNZ_CP120400.1 Lassopeptides: PVE91_RS09960_lassopeptideNZ_JABDRV010000002.1 Lassopeptides: HRL60_RS08285_lassopeptideNZ_JADCQA010000003.1 Lassopeptides: IMX13_RS03920_lassopeptideNZ_JAEDVS010000016.1 Lassopeptides: JAK50_RS09365_lassopeptideNZ_JAEDVW010000040.1 Lassopeptides: JAK53_RS10000_lassopeptideNZ_JAEDWA010000005.1 Lassopeptides: JAK63_RS01795_lassopeptideNZ_JAEDWK010000019.1 Lassopeptides: JAK51_RS11395_lassopeptideNZ_JAEDWU010000002.1 Lassopeptides: JAK37_RS06750_lassopeptideNZ_JAKJQX010000001.1 Lassopeptides: MT466_RS00850_lassopeptideNZ_JAQQGI010000001.1 Lassopeptides: PQS91_RS01155_lassopeptideNZ_JVHP01000037.1 Lassopeptides: ADI44_RS25485_lassopeptideNZ_JVPM01000019.1 Lassopeptides: ADH50_RS20965_lassopeptideNZ_JVUI01000038.1 Lassopeptides: ADG58_RS23065_lassopeptideNZ_OBEE01000001.1 Lassopeptides: CRO53_RS21815_lassopeptideNZ_OU943334.1 Lassopeptides: LNN95_RS11880_lassopeptideNZ_RHPZ01000001.1 Lassopeptides: EGJ03_RS21120_lassopeptideNZ_RHQE01000001.1 Lassopeptides: EGJ89_RS22430_lassopeptideNZ_SOCO01000001.1 Lassopeptides: N440_RS20340_lassopeptide

Lassopeptides: SMAL_RS21110_lassopeptide

16

NNGCMWNTVF

25

N+G +W+ VF

3

NHGTLWDGVF

12

13.9%

NZ_CP069611.1:

Lanthipeptides: allorf_33926_34045_lanthipeptide

27

NIYRCLTPY

35

++YRC +PY

5

SLYRCFSPY

13

allorf_0221021_0221083

Leader:

MRLMGIHEA

Core:

TIAQYTCILCD

Core with dehydrations:

DhbIAQYDhbCysILCysD

antiSMASH-DB 4.0 matches for allorf_0221021_0221083

100.0%

NZ_CP015883.1and 1 other:

NZ_JAASJP010000011.1 Lanthipeptides: allorf_58686_58748_lanthipeptide

Lanthipeptides: allorf_0221021_0221083_lanthipeptide

1

TIAQYTCILCD

11

TIAQYTCILCD

1

TIAQYTCILCD

11

MIBiG 4.0 matches for allorf_0221021_0221083

14.8%

BGC0002144.3 (RCCGEPOP_RS37510):

LAP: phazolicin

6

TCILCD

11

TC CD

2

TCARCD

7

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.29 out of 29.38

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 16.05 out of 18.16

Confidence: strong

Additional weak hits (3):

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.83 out of 26.85

Confidence: weak

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 19.19 out of 29.51

Confidence: weak

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 15.62 out of 18.46

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

A6B47_RS00875 - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 2630.3 Da

Molecular weight: 2632.0 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 2650.0 Da N = 1; 2668.0 Da N = 2

A6B47_RS00880 - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 4017.0 Da

Molecular weight: 4019.5 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 4037.6 Da N = 1; 4055.6 Da N = 2; 4073.6 Da N = 3; 4091.6 Da N = 4; 4109.6 Da N = 5

A6B47_RS15575 - Class II

Cleavage pHMM score: -5.80

RODEO score: 0

Monoisotopic mass: 5924.7 Da

Molecular weight: 5928.4 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 5946.4 Da N = 1; 5964.4 Da N = 2; 5982.4 Da N = 3; 6000.5 Da N = 4; 6018.5 Da N = 5; 6036.5 Da N = 6; 6054.5 Da N = 7

allorf_0205278_0205448 - Class II

Cleavage pHMM score: -6.90

RODEO score: 0

Monoisotopic mass: 4130.1 Da

Molecular weight: 4132.8 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 4150.8 Da N = 1; 4168.8 Da N = 2; 4186.8 Da N = 3; 4204.8 Da N = 4

allorf_0221021_0221083 - Class II

Cleavage pHMM score: -6.00

RODEO score: 0

Monoisotopic mass: 1206.6 Da

Molecular weight: 1207.4 Da

Number of bridges: 2

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
FuR variant 1	Ferric Uptake Regulator

NZ_CP015883.1 - Region 2 - NRPS,arylpolyene

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Location: 514,732 - 558,602 nt. (total: 43,871 nt) Show pHMM detection rules used

arylpolyene: (APE_KS1 or APE_KS2)
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

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KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

A6B47_RS02720: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

A6B47_RS02775: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

Transferases: PPTase

A6B47_RS02675: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Lyases: decarboxylase

A6B47_RS02795: Decarboxylase, pyridoxal-dependent

smcogs: SMCOG1180: Decarboxylase, pyridoxal-dependent

Ligases: ligase synthase

A6B47_RS02745: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

A6B47_RS15745: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Translocases: permease

A6B47_RS02800: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001261.3	0.58	NRPS	AM-toxin	Alternaria alternata
BGC0001166.5	0.57	NRPS	HC-toxin	Alternaria jesenskae
BGC0002286.3	0.54	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002008.3	0.38	other (other)	aryl polyenes	Xenorhabdus doucetiae
BGC0000836.5	0.37	other (other)	APE Ec	Escherichia coli CFT073
BGC0000837.4	0.35	other (other)	APE Vf	Aliivibrio fischeri ES114
BGC0000888.5	0.34	other (other)	bacilysin	Bacillus sp. CS93
BGC0001928.2	0.33	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0002518.3	0.32	NRPS	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0002547.2	0.32	PKS	youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4	Streptomyces youssoufiensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001261.3	0.62	NRPS	AM-toxin	Alternaria alternata
BGC0001166.5	0.62	NRPS	HC-toxin	Alternaria jesenskae
BGC0002286.3	0.61	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002008.3	0.51	other (other)	aryl polyenes	Xenorhabdus doucetiae
BGC0000836.5	0.51	other (other)	APE Ec	Escherichia coli CFT073
BGC0000837.4	0.49	other (other)	APE Vf	Aliivibrio fischeri ES114
BGC0000888.5	0.49	other (other)	bacilysin	Bacillus sp. CS93
BGC0001928.2	0.48	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0002518.3	0.47	NRPS	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0002547.2	0.47	PKS	youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4	Streptomyces youssoufiensis

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.27 out of 26.06

Confidence: strong

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.55 out of 18.46

Confidence: strong

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.93 out of 30.25

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.54 out of 26.06

Confidence: medium

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 29.42 out of 32.74

Confidence: medium

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.37 out of 29.38

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.31 out of 30.25

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.99 out of 30.25

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.28 out of 27.78

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.48 out of 26.06

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 16.78 out of 18.16

Confidence: strong

Additional weak hits (2):

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 19.58 out of 27.18

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 23.73 out of 29.65

Confidence: weak

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 2, location 514731 - 558602:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

A6B47_RS02745: X

AMP-binding (15..416): X

nrpys: Gly, Ala, Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: LGMAFDPSIAQFDIISCGEFNFYGPSECSVYSTV
Nearest Stachelhaus code(s):: Cap DPQDIGIVNK (50% 8Å match)
Stachelhaus code match:: 60% (weak)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ColR	Phenol-responsive regulator
FuR variant 1	Ferric Uptake Regulator
FuR variant 2	Ferric Uptake Regulator
MogR	Repressor of flagellar motility genes
RpoN	Regulator of nitrogen assimilation and virulence

NZ_CP015883.1 - Region 3 - terpene-precursor

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Location: 889,652 - 910,533 nt. (total: 20,882 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: peptidase

A6B47_RS04460: methionine aminopeptidase

smcogs: SMCOG1172: methionine aminopeptidase

Ligases: synthetase

A6B47_RS04495: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002309.2	0.36	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000639.3	0.34	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.34	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0001605.3	0.32	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001075.5	0.31	PKS, terpene	aurachin RE	Rhodococcus erythropolis
BGC0001456.3	0.30	terpene	isorenieratene	Streptomyces argillaceus
BGC0000286.3	0.30	PKS	viguiepinol	Streptomyces sp. KO-3988

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.39	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0002309.2	0.36	terpene	cattleyene	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000639.3	0.34	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000642.3	0.34	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0001605.3	0.32	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001075.5	0.31	PKS, terpene	aurachin RE	Rhodococcus erythropolis
BGC0001456.3	0.30	terpene	isorenieratene	Streptomyces argillaceus
BGC0000286.3	0.30	PKS	viguiepinol	Streptomyces sp. KO-3988

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

A6B47_RS04495: PT_FPPS_like

Domain 1 (29 - 276): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.25 out of 27.78

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.38 out of 27.78

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.87 out of 28.19

Confidence: medium

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
ZuR variant 1	Zinc-responsive repressor

NZ_CP015883.1 - Region 4 - RRE-containing

Download region GenBank file

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Location: 1,250,765 - 1,271,898 nt. (total: 21,134 nt) Show pHMM detection rules used

RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: reductase

A6B47_RS06405: alkyl hydroperoxide reductase subunit

smcogs: SMCOG1176: alkyl hydroperoxide reductase subunit

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000585.5	0.44	ribosomal	microcin C7	Escherichia coli
BGC0000626.3	0.40	ribosomal	thuricin	Bacillus thuringiensis
BGC0000528.5	0.40	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001743.3	0.40	ribosomal	plantaricyclin	Lactobacillus plantarum
BGC0001660.3	0.40	ribosomal	mathermycin	Marinactinospora thermotolerans
BGC0001210.5	0.40	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000616.4	0.39	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0000527.5	0.39	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0001787.3	0.39	ribosomal	suicin 3908	Streptococcus suis
BGC0000521.3	0.38	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000585.5	0.44	ribosomal	microcin C7	Escherichia coli
BGC0000626.3	0.40	ribosomal	thuricin	Bacillus thuringiensis
BGC0000528.5	0.40	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001743.3	0.40	ribosomal	plantaricyclin	Lactobacillus plantarum
BGC0001660.3	0.40	ribosomal	mathermycin	Marinactinospora thermotolerans
BGC0001210.5	0.40	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000616.4	0.39	ribosomal	amylocyclicin	Bacillus velezensis FZB42
BGC0000527.5	0.39	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0001787.3	0.39	ribosomal	suicin 3908	Streptococcus suis
BGC0000521.3	0.38	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 25.18 out of 26.06

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.86 out of 26.06

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.52 out of 26.06

Confidence: medium

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 26.12 out of 26.12

Confidence: strong

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.70 out of 20.97

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.98 out of 27.78

Confidence: medium

Additional weak hits (4):

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.13 out of 26.85

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.90 out of 31.73

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 24.16 out of 35.63

Confidence: weak

HypR

Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.79 out of 22.40

Confidence: weak

RREFinder

TFBS Finder

RRE predictions

: RRE type: Pantocin_Microcin_RRE; Location: 5 - 89; Score: 38.0

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
LuxO	Repressor of luminescence
MogR	Repressor of flagellar motility genes

NZ_CP015883.1 - Region 5 - cyclic-lactone-autoinducer

Download region GenBank file

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Location: 1,674,786 - 1,695,514 nt. (total: 20,729 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001291.3	0.41	ribosomal	enterocin NKR-5-3B	Enterococcus faecium
BGC0001948.3	0.37	other (other)	naseseazine C, C3-aryl pyrroloindolines	Streptomyces sp.
BGC0000046.4	0.35	PKS	depudecin	Alternaria brassicicola
BGC0002227.3	0.31	NRPS	AKML B, AKML D, AKML A, AKML C	Aspergillus luchuensis IFO 4308
BGC0002667.2	0.30	ribosomal	estericin A	Clostridium estertheticum
BGC0000688.4	0.29	terpene	copalyl diphosphate	Diaporthe amygdali
BGC0001954.2	0.28	NRPS, PKS	wortmanamide A, wortmanamide B	Talaromyces wortmannii
BGC0001366.5	0.27	PKS	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2
BGC0002058.3	0.27	NRPS, PKS	mutanocyclin	Streptococcus mutans B04Sm5
BGC0002287.2	0.27	NRPS	mutanocyclin, leuvalin, tyrvalin	Streptococcus mutans

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001291.3	0.41	ribosomal	enterocin NKR-5-3B	Enterococcus faecium
BGC0001948.3	0.37	other (other)	naseseazine C, C3-aryl pyrroloindolines	Streptomyces sp.
BGC0000046.4	0.35	PKS	depudecin	Alternaria brassicicola
BGC0002227.3	0.31	NRPS	AKML B, AKML D, AKML A, AKML C	Aspergillus luchuensis IFO 4308
BGC0002667.2	0.30	ribosomal	estericin A	Clostridium estertheticum
BGC0000688.4	0.29	terpene	copalyl diphosphate	Diaporthe amygdali
BGC0001954.2	0.28	NRPS, PKS	wortmanamide A, wortmanamide B	Talaromyces wortmannii
BGC0001366.5	0.27	PKS	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2
BGC0002058.3	0.27	NRPS, PKS	mutanocyclin	Streptococcus mutans B04Sm5
BGC0002287.2	0.27	NRPS	mutanocyclin, leuvalin, tyrvalin	Streptococcus mutans

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 28.99 out of 30.25

Confidence: strong

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.08 out of 23.79

Confidence: medium

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.55 out of 19.26

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.50 out of 23.79

Confidence: medium

TFBS Finder

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
ColR	Phenol-responsive regulator
IolR	Regulator of the inositol catabolism

NZ_CP015884.1 - Region 1 - RiPP-like

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Location: 114,557 - 124,703 nt. (total: 10,147 nt) Show pHMM detection rules used

Region on contig edge.

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	RiPP-like	Similarity score	Type	Compound(s)	Organism
BGC0000618.3		0.56	ribosomal	enterocin A	Enterococcus faecium DO

Reference	Aggregated	Similarity score	Type	Compound(s)	Organism
BGC0000618.3		0.56	ribosomal	enterocin A	Enterococcus faecium DO

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 15.06 out of 18.16

Confidence: strong

Additional weak hits (2):

LuxO

Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.10 out of 25.88

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator

NZ_CP015885.1 - Region 1 - RiPP-like

Download region GenBank file

Download region SVG

Location: 37,487 - 49,637 nt. (total: 12,151 nt) Show pHMM detection rules used

Region on contig edge.

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002579.2	0.51	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0002577.2	0.48	ribosomal	lactococcin G	Lactococcus lactis
BGC0000617.5	0.44	ribosomal	coagulin	Bacillus coagulans
BGC0000558.5	0.43	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0001862.4	0.41	ribosomal	pallidocin	Aeribacillus pallidus
BGC0002674.2	0.40	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0000484.5	0.39	ribosomal	glycocin F	Lactobacillus plantarum
BGC0001863.4	0.39	ribosomal, terpene	bacillicn CER074	Bacillus mycoides
BGC0001388.3	0.38	ribosomal	gassericin E	Lactobacillus gasseri
BGC0000619.3	0.38	ribosomal	gassericin T	Lactobacillus gasseri

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002579.2	0.51	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0002577.2	0.48	ribosomal	lactococcin G	Lactococcus lactis
BGC0000617.5	0.44	ribosomal	coagulin	Bacillus coagulans
BGC0000558.5	0.43	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0001862.4	0.41	ribosomal	pallidocin	Aeribacillus pallidus
BGC0002674.2	0.40	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0000484.5	0.39	ribosomal	glycocin F	Lactobacillus plantarum
BGC0001863.4	0.39	ribosomal, terpene	bacillicn CER074	Bacillus mycoides
BGC0001388.3	0.38	ribosomal	gassericin E	Lactobacillus gasseri
BGC0000619.3	0.38	ribosomal	gassericin T	Lactobacillus gasseri

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.38 out of 25.88

Confidence: medium

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.01 out of 32.93

Confidence: medium

Additional weak hits (1):

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.01 out of 26.85

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
LexA variant 3	Repressor of DNA damage response
PsrA	Oleic acid responsive regulator