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Overview
1.1
1.2
1.3
1.4
1.5
2.1
3.1

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP015883.1 (Enterococcus faecalis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | lanthipeptide-class-ii | 200,141 | 223,122 | High | cytolysin ClyLl/cytolysin ClyLs | ribosomal:RiPP:Lanthipeptide
Region 1.2 | arylpolyene,NRPS | 514,732 | 558,602 |
Region 1.3 | terpene-precursor | 889,652 | 910,533 |
Region 1.4 | RRE-containing | 1,250,765 | 1,271,898 |
Region 1.5 | cyclic-lactone-autoinducer | 1,674,786 | 1,695,514 |

NZ_CP015884.1 (Enterococcus faecalis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 2.1 | RiPP-like | 114,557 | 124,703 |

NZ_CP015885.1 (Enterococcus faecalis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 3.1 | RiPP-like | 37,487 | 49,637 | Low | carnobacteriocin XY | ribosomal:RiPP

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1.1 | lanthipeptide-class-ii | 200,141 | 223,122 | High | cytolysin ClyLl/cytolysin ClyLs | ribosomal:RiPP:Lanthipeptide
Region 1.2 | arylpolyene,NRPS | 514,732 | 558,602 |
Region 1.3 | terpene-precursor | 889,652 | 910,533 |
Region 1.4 | RRE-containing | 1,250,765 | 1,271,898 |
Region 1.5 | cyclic-lactone-autoinducer | 1,674,786 | 1,695,514 |
Region 2.1 | RiPP-like | 114,557 | 124,703 |
Region 3.1 | RiPP-like | 37,487 | 49,637 | Low | carnobacteriocin XY | ribosomal:RiPP

Compact view
NZ_CP015883.1 - Region 1 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 200,141 - 223,122 nt. (total: 22,982 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
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Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: protease
A6B47_RS00860: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase
A6B47_RS00870: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000504.5 |  | 0.96 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000500.5 |  | 0.53 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000623.3 |  | 0.49 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0001407.5 |  | 0.48 | ribosomal | bicereucin | Bacillus cereus SJ1
BGC0000516.4 |  | 0.47 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0002698.2 |  | 0.47 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0002674.2 |  | 0.46 | ribosomal | enterocin F4-9 | Enterococcus faecalis
BGC0001210.5 |  | 0.45 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000502.5 |  | 0.45 | ribosomal | cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7 | Bacillus cereus
BGC0001862.4 |  | 0.44 | ribosomal | pallidocin | Aeribacillus pallidus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000504.5 |  | 0.96 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000500.5 |  | 0.53 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000623.3 |  | 0.49 | ribosomal | plantaricin W α, plantaricin W β | Lactobacillus plantarum
BGC0001407.5 |  | 0.48 | ribosomal | bicereucin | Bacillus cereus SJ1
BGC0000516.4 |  | 0.47 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0002698.2 |  | 0.47 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0002674.2 |  | 0.46 | ribosomal | enterocin F4-9 | Enterococcus faecalis
BGC0001210.5 |  | 0.45 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000502.5 |  | 0.45 | ribosomal | cerecidin, cerecidin A1, cerecidin A2, cerecidin A3, cerecidin A4, cerecidin A5, cerecidin A6, cerecidin A7 | Bacillus cereus
BGC0001862.4 |  | 0.44 | ribosomal | pallidocin | Aeribacillus pallidus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for A6B47_RS00870

A6B47_RS00875
Leader:
MLNKENQENYYSNKLELVGPSFEELSLEEMEAIQGS
Core:
G D V Q A E T T P A C F T I G L G V G A L F S A K F C
Core with dehydrations:
G D V Q A E Dhb Dhb P A Cys F Dhb I G L G V G A L F Dha A K F Cys

#### antiSMASH-DB 4.0 matches for A6B47_RS00875

100.0%
NZ_AP026721.1 and 35 others:
NZ_CP015883.1 Lanthipeptides: A6B47_RS00875_lanthipeptide NZ_CP028286.1 Lanthipeptides: CEQ02_RS16115_lanthipeptide NZ_CP028721.1 Lanthipeptides: C7I32_RS15475_lanthipeptide NZ_CP028835.1 Lanthipeptides: C9432_RS02740_lanthipeptide NZ_CP028837.1 Lanthipeptides: C9432_RS15935_lanthipeptide NZ_CP033787.1 Lanthipeptides: EGX75_RS02740_lanthipeptide NZ_CP039296.1 Lanthipeptides: E7T02_RS02755_lanthipeptide NZ_CP045045.1 Lanthipeptides: F9293_RS12755_lanthipeptide NZ_CP075604.2 Lanthipeptides: KKP64_RS02155_lanthipeptide NZ_CP085289.1 Lanthipeptides: LIT95_RS07630_lanthipeptide NZ_CP085291.1 Lanthipeptides: LIT96_RS04335_lanthipeptide NZ_CP085297.1 Lanthipeptides: LIT97_RS14520_lanthipeptide NZ_CP086726.1 Lanthipeptides: LM507_RS03415_lanthipeptide NZ_CP091901.1 Lanthipeptides: L5I17_RS09010_lanthipeptide NZ_CP091905.1 Lanthipeptides: L5I20_RS14940_lanthipeptide NZ_CP091907.1 Lanthipeptides: L5I26_RS13265_lanthipeptide NZ_CP093957.1 Lanthipeptides: MPM64_RS01385_lanthipeptide NZ_CP116962.1 Lanthipeptides: PO880_RS13030_lanthipeptide NZ_JAASJP010000011.1 Lanthipeptides: HCH27_RS13275_lanthipeptide NZ_JAHZNN010000041.1 Lanthipeptides: K0X81_RS16410_lanthipeptide NZ_JAKTAU010000028.1 Lanthipeptides: MKK46_RS14535_lanthipeptide NZ_JALSCL010000035.1 Lanthipeptides: NEI30_RS13375_lanthipeptide NZ_JAQDOF010000024.1 Lanthipeptides: PGP79_RS14595_lanthipeptide NZ_JAQKZU010000014.1 Lanthipeptides: PMV60_RS12615_lanthipeptide NZ_KB932317.1 Lanthipeptides: Q95_RS09840_lanthipeptide NZ_KB932336.1 Lanthipeptides: Q9C_RS13350_lanthipeptide NZ_KB944697.1 Lanthipeptides: WO3_RS18030_lanthipeptide NZ_KB944708.1 Lanthipeptides: WO5_RS05650_lanthipeptide NZ_KB944753.1 Lanthipeptides: WO9_RS06460_lanthipeptide NZ_KB944762.1 Lanthipeptides: WOA_RS17470_lanthipeptide NZ_KB944819.1 Lanthipeptides: WOK_RS14355_lanthipeptide NZ_KB946767.1 Lanthipeptides: UK1_RS12990_lanthipeptide NZ_KB947483.1 Lanthipeptides: WUI_RS10440_lanthipeptide NZ_KZ845881.1 Lanthipeptides: EB41_RS04380_lanthipeptide NZ_NGMY01000001.1 Lanthipeptides: A5862_RS02370_lanthipeptide
Lanthipeptides: PO855_RS02215_lanthipeptide
1
G D V Q A E T T P A C F T I G L G V G A L F S A K F C
27
G D V Q A E T T P A C F T I G L G V G A L F S A K F C
1
G D V Q A E T T P A C F T I G L G V G A L F S A K F C
27
85.2%
NZ_CP011974.1 and 2 others:
NZ_CP115914.1 Lanthipeptides: PGN40_RS02040_lanthipeptide NZ_MWSI01000006.1 Lanthipeptides: B1B01_RS20140_lanthipeptide
Lanthipeptides: BEH_RS02100_lanthipeptide
1
G D V Q A E T T P A C F T I G L G V G A L F S A K F C
27
G D V Q A E T T P C F T I G L G V G A L S A C
1
G D V Q A E T T P V C F T I G L G V G A L V S A A G C
27
77.8%
NZ_JH791802.1 and 2 others:
NZ_MIFM01000001.1 Lanthipeptides: BHL22_RS00410_lanthipeptide NZ_NINI01000009.1 Lanthipeptides: CEV12_RS07260_lanthipeptide
Lanthipeptides: IKS_RS03655_lanthipeptide
1
G D V Q A E T T P A C F T I G L G V G A L F S A K F C
27
G D V Q A E T T P C F T+G L G V G+L S A C
1
G D V Q A E T T P V C F T V G L G V G S L V S A S V C
27
with 108 more sequence matches
Only the first 10 are displayed here.
74.1%
NZ_JH791802.1 and 2 others:
NZ_MIFM01000001.1 Lanthipeptides: BHL22_RS00405_lanthipeptide NZ_NINI01000009.1 Lanthipeptides: CEV12_RS07255_lanthipeptide
Lanthipeptides: IKS_RS03660_lanthipeptide
1
G D V Q A E T T P A C F T I G L G V G A L F S A K F C
27
G D V Q A E T T P C F T+G L G+G+L S A C
1
G D V Q A E T T P V C F T V G L G I G S L V S A S V C
27
71.4%
NZ_KB946334.1:
Lanthipeptides: UC7_RS10230_lanthipeptide
1
G D V Q A E T T P A C-F T I G L G V G A L F S A K F C
27
G D V Q E T T P C F T I G+G+G A L S K+C
1
G D V Q P E T T P I C G F T I G I G I G A L A S V K W C
28
71.4%
NZ_KB946334.1:
Lanthipeptides: UC7_RS10250_lanthipeptide
1
G D V Q A E T T P A C-F T I G L G V G A L F S A K F C
27
G D V Q E T T P C F T I G+G+G A L S K+C
1
G D V Q P E T T P L C G F T I G I G I G A L V S V K W C
28
70.0%
NZ_NVAW01000030.1 and 1 other:
NZ_NVEP01000021.1 Lanthipeptides: COL17_RS24445_lanthipeptide
Lanthipeptides: COK11_RS25885_lanthipeptide
1
G D V Q A E T T P A C---F T I G L G V G A L F S A K F C
27
G D V+ E T T P A C F T I G L G+G A L S A C
1
G D V K P E T T P A C L A G F T I G L G I G A L A S A A G C
30
66.7%
NZ_CP025701.1:
Lanthipeptides: C0569_RS26125_lanthipeptide
1
G D V Q A E T T P A C---F T I G L G V G A L F S A K F C
27
G D V+ E T T P A C F T+G L G+G A L S A C
1
G D V K P E T T P A C L A G F T V G L G I G A L A S A A G C
30
63.0%
NZ_JACDUU010000003.1:
Lanthipeptides: HNQ85_RS08035_lanthipeptide
1
G D V Q A E T T P A C F T I G L G V G A L F S A K F C
27
G D V Q E T+P A C T I G+G+G S F C
1
G D V Q P E T S P A C V T I G I G I G I G I S K L F C
27
59.3%
NZ_JAOVZP010000016.1 and 3 others:
NZ_NHVL01000036.1 Lanthipeptides: CEU70_RS27720_lanthipeptide NZ_NTYE01000081.1 Lanthipeptides: CN490_RS28165_lanthipeptide NZ_NVMN01000027.1 Lanthipeptides: CON30_RS23205_lanthipeptide
Lanthipeptides: OF830_RS26725_lanthipeptide
1
G D V Q A E T T P A C F T I G L G V G A L F S A K F C
27
D V Q E T T P A C T L G +F S K+C
1
S D V Q P E T T P A C V T-A L T T G I I F S I K W C
26
58.6%
NZ_JAOVZP010000016.1 and 3 others:
NZ_NHVL01000036.1 Lanthipeptides: CEU70_RS27725_lanthipeptide NZ_NTYE01000081.1 Lanthipeptides: CN490_RS28170_lanthipeptide NZ_NVMN01000027.1 Lanthipeptides: CON30_RS23200_lanthipeptide
Lanthipeptides: OF830_RS26730_lanthipeptide
1
G D V Q A E T T P A C---F T I G L G V G A L F S A K F C
27
D V Q E T T P A C F T I G V +F S + C
1
S D V Q P E T T P A C A V A F T I G A T V--I F S V R N C
28
57.1%
NZ_JANFNS010000003.1:
Lanthipeptides: NOM90_RS11325_lanthipeptide
2
D V Q A E T T P A C-F T I G L G V G A L F S A K F C
27
D V Q E T T P C F +G+G+G A+ S A C
2
D V Q P E T T P V C G F F V G V G I G A I I S A T A C
28
55.6%
NZ_JACSPU010000002.1:
Lanthipeptides: H9630_RS06775_lanthipeptide
1
G D V Q A E T T P A C F T I G L G V G A L F S A K F C
27
D V E T T P A C G L F S K F C
1
S D V A P E T T P A C-V A A F A T G L L F S I K F C
26

#### MIBiG 4.0 matches for A6B47_RS00875

27.0%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
7
T T P A C F T I G L G V G A L-------F S A K F C
27
T P A + L G+ A+ S A F C
1
T D P A V T G L I L G I V A I Q A G V A V G V S A A F C
28
11.8%
BGC0000535.4 (ADJ56352.1):
Lanthipeptide: nisin A
8
T P A C F T
13
T P C T
8
T P G C K T
13
7.8%
BGC0002120.3 (NQE92413.1):
Lanthipeptide: nocathioamide A
9
P A C F T I G
15
P A C T+
38
P A C H T L S
44
A6B47_RS00880
Leader:
MENLNVVPSFEELSVEEMEAIQGS
Core:
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
Core with dehydrations:
G D V Q A E Dhb Dhb P V Cys A V A A Dhb A A A Dha Dha A A Cys G W V G G G I F Dhb G V Dhb V V V Dha L K H Cys

#### antiSMASH-DB 4.0 matches for A6B47_RS00880

100.0%
NZ_AP026721.1 and 34 others:
NZ_CP015883.1 Lanthipeptides: A6B47_RS00880_lanthipeptide NZ_CP028286.1 Lanthipeptides: CEQ02_RS16120_lanthipeptide NZ_CP028721.1 Lanthipeptides: C7I32_RS15480_lanthipeptide NZ_CP028835.1 Lanthipeptides: C9432_RS02735_lanthipeptide NZ_CP028837.1 Lanthipeptides: C9432_RS15930_lanthipeptide NZ_CP033787.1 Lanthipeptides: EGX75_RS02745_lanthipeptide NZ_CP039296.1 Lanthipeptides: E7T02_RS02750_lanthipeptide NZ_CP045045.1 Lanthipeptides: F9293_RS12760_lanthipeptide NZ_CP075604.2 Lanthipeptides: KKP64_RS02150_lanthipeptide NZ_CP085289.1 Lanthipeptides: LIT95_RS07625_lanthipeptide NZ_CP085291.1 Lanthipeptides: LIT96_RS04340_lanthipeptide NZ_CP085297.1 Lanthipeptides: LIT97_RS14515_lanthipeptide NZ_CP086726.1 Lanthipeptides: LM507_RS03420_lanthipeptide NZ_CP091901.1 Lanthipeptides: L5I17_RS09015_lanthipeptide NZ_CP091905.1 Lanthipeptides: L5I20_RS14935_lanthipeptide NZ_CP091907.1 Lanthipeptides: L5I26_RS13260_lanthipeptide NZ_CP093957.1 Lanthipeptides: MPM64_RS01390_lanthipeptide NZ_CP116962.1 Lanthipeptides: PO880_RS13035_lanthipeptide NZ_JAASJP010000011.1 Lanthipeptides: HCH27_RS13280_lanthipeptide NZ_JAHZNN010000041.1 Lanthipeptides: K0X81_RS16405_lanthipeptide NZ_JAKTAU010000028.1 Lanthipeptides: MKK46_RS14540_lanthipeptide NZ_JALSCL010000035.1 Lanthipeptides: NEI30_RS13380_lanthipeptide NZ_JAQDOF010000024.1 Lanthipeptides: PGP79_RS14600_lanthipeptide NZ_JAQKZU010000014.1 Lanthipeptides: PMV60_RS12620_lanthipeptide NZ_KB932317.1 Lanthipeptides: Q95_RS09835_lanthipeptide NZ_KB932336.1 Lanthipeptides: Q9C_RS13355_lanthipeptide NZ_KB944697.1 Lanthipeptides: WO3_RS18035_lanthipeptide NZ_KB944708.1 Lanthipeptides: WO5_RS05645_lanthipeptide NZ_KB944753.1 Lanthipeptides: WO9_RS06455_lanthipeptide NZ_KB944762.1 Lanthipeptides: WOA_RS17465_lanthipeptide NZ_KB944819.1 Lanthipeptides: WOK_RS14360_lanthipeptide NZ_KB946767.1 Lanthipeptides: UK1_RS12995_lanthipeptide NZ_KB947483.1 Lanthipeptides: WUI_RS10435_lanthipeptide NZ_KZ845881.1 Lanthipeptides: EB41_RS04385_lanthipeptide
Lanthipeptides: PO855_RS02210_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
93.2%
NZ_CP011974.1 and 2 others:
NZ_CP115914.1 Lanthipeptides: PGN40_RS02045_lanthipeptide NZ_MWSI01000006.1 Lanthipeptides: B1B01_RS20135_lanthipeptide
Lanthipeptides: BEH_RS02105_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q A E T T P V C A+A A T A A A S S A A C G+V G G G I F T G V T V V V S L K C
1
G D V Q A E T T P V C A I A A T A A A S S A A C G Y V G G G I F T G V T V V V S L K S C
44
90.9%
NZ_CP011974.1 and 2 others:
NZ_CP115914.1 Lanthipeptides: PGN40_RS02050_lanthipeptide NZ_MWSI01000006.1 Lanthipeptides: B1B01_RS20130_lanthipeptide
Lanthipeptides: BEH_RS02110_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q A E T T P V C A+A A T A A A S S A A C G+V G G G I F T G V T V V V+L K C
1
G D V Q A E T T P V C A I A A T A A A S S A A C G Y V G G G I F T G V T V V V T L K S C
44
with 107 more sequence matches
Only the first 10 are displayed here.
86.4%
NZ_JH791802.1 and 5 others:
NZ_MIFM01000001.1 Lanthipeptides: BHL22_RS00420_lanthipeptide NZ_MIFM01000001.1 Lanthipeptides: BHL22_RS00415_lanthipeptide NZ_NINI01000009.1 Lanthipeptides: CEV12_RS07275_lanthipeptide NZ_NINI01000009.1 Lanthipeptides: CEV12_RS07270_lanthipeptide NZ_NINI01000009.1 Lanthipeptides: CEV12_RS07265_lanthipeptide
Lanthipeptides: IKS_RS30065_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q A E T T P V C A+A A T A A S S A A C G W V G G G I T G V T V V++L K C
1
G D V Q A E T T P V C A I A A T T A A S S A A C G W V G G G I A T G V T V V I T L K S C
44
84.1%
NZ_CP025701.1:
Lanthipeptides: C0569_RS26130_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q A E T T P V C A+A A T A A A S S C G G G I T G V T V V V S L K H C
1
G D V Q A E T T P V C A I A A T A A A S S G I C A A T G G G I A T G V T V V V S L K H C
44
81.8%
NZ_NVAW01000030.1 and 1 other:
NZ_NVEP01000021.1 Lanthipeptides: COL17_RS24440_lanthipeptide
Lanthipeptides: COK11_RS25880_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q A E T T P V C A V A A T A A A S S C G G I T G V T V V V S L K C
1
G D V Q A E T T P V C A V A A T A A A S S G V C A A T G A G I A T G V T V V V S L K S C
44
77.3%
NZ_MIFM01000001.1 and 1 other:
NZ_NINI01000009.1 Lanthipeptides: CEV12_RS07280_lanthipeptide
Lanthipeptides: BHL22_RS00425_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q A E T T P V C A V+ S S A A C G W V G G I T G V T V V V+L K C
1
G D V Q A E T T P V C A V S V A T M T S S A A C G W V A G G I A T G V T V V V T L K S C
44
72.7%
NZ_CP062165.1 and 5 others:
NZ_CP062165.1 Lanthipeptides: JNUCC31_RS17165_lanthipeptide NZ_QICW01000005.1 Lanthipeptides: DEU73_RS14625_lanthipeptide NZ_QICW01000005.1 Lanthipeptides: DEU73_RS14625_lanthipeptide NZ_QLLI01000007.1 Lanthipeptides: DET54_RS17330_lanthipeptide NZ_QLLI01000007.1 Lanthipeptides: DET54_RS17330_lanthipeptide
Lanthipeptides: JNUCC31_RS17165_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q E T T P V C A V A A T A A S S A C V G G G I G V T+V+++K C
1
G D V Q P E T T P V C A V A A T V A A S S A T C A A V G G G I A V G V T I V L T I K S C
44
72.7%
NZ_JANFNS010000003.1:
Lanthipeptides: NOM90_RS11330_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
D V Q E T T P V C A V A A T A A S S A C V G G G+ G V T V V++L K C
1
A D V Q P E T T P V C A V A A T V A A S S A T C A A V G G G V A V G V T V V L T L K T C
44
70.5%
NZ_KB946334.1 and 1 other:
NZ_KB946334.1 Lanthipeptides: UC7_RS10235_lanthipeptide
Lanthipeptides: UC7_RS10245_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q A E T T P V C A++A T A A S S A A C V G G I T G+T+V++ K C
1
G D V Q A E T T P V C A I S A T V A A S S A A C A G V G A G I G T G I T I V L T F K R C
44
68.2%
NZ_KB946334.1:
Lanthipeptides: UC7_RS10240_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q E T T P V C A++A T A A S S A A C V G G I T G+T+V++ K C
1
G D V Q V E T T P V C A I S A T V A A S S A A C A G V G A G I G T G I T I V L T F K R C
44
68.2%
NZ_LN831278.1:
Lanthipeptides: BN1360_RS08835_lanthipeptide
2
D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
D V Q E T T P+C A V A A T A A S S A C V G G G I G V T+V+++K C
2
D V Q P E T T P I C A V A A T V A A S S A T C A A V G G G I A V G V T I V L T I K S C
44
65.9%
NC_014098.1:
Lanthipeptides: BTUS_RS14190_lanthipeptide
1
G D V Q A E T T P V C A V A A T A A A S S A A C G W V G G G I F T G V T V V V S L K H C
44
G D V Q A E T T P+C A A T A S S A A C V G G I G V T+V+++K C
1
G D V Q A E T T P I C Y T A A T V T A S S A A C A G V G A G I V A G V T I V L T I K R C
44
A6B47_RS15575
Leader:
MKEIVVDNFAGG
Core:
G G A S T G T E H A I G R S V D V A I N H D P D A I A M H E A N H P N T K H Y C E S V W E S T R E M L P M D G Q
Core with dehydrations:
G G A Dha Dhb G Dhb E H A I G R Dha V D V A I N H D P D A I A M H E A N H P N Dhb K H Y Cys E Dha V W E Dha Dhb R E M L P M D G Q

#### antiSMASH-DB 4.0 matches for A6B47_RS15575

100.0%
NZ_CP015883.1:
Lanthipeptides: A6B47_RS15575_lanthipeptide
1
G G A S T G T E H A I G R S V D V A I N H D P D A I A M H E A N H P N T K H Y C E S V W E S T R E M L P M D G Q
56
G G A S T G T E H A I G R S V D V A I N H D P D A I A M H E A N H P N T K H Y C E S V W E S T R E M L P M D G Q
1
G G A S T G T E H A I G R S V D V A I N H D P D A I A M H E A N H P N T K H Y C E S V W E S T R E M L P M D G Q
56
16.1%
NZ_CP050504.1:
Lanthipeptides: allorf_0161193_0161369_lanthipeptide
1
G G A S T G T E H A I G R S V D V A I N H
21
G A G E H R D A+ H
12
G T A C P G Y E H C R A R L R D D A L L H
32
12.5%
NZ_CP020327.1:
Lanthipeptides: allorf_1389413_1389616_lanthipeptide
34
P N T K H Y C E S V W E S T R E M L P
52
P+ K C S +S+ L P
16
P S C K A V C S S A C D S S T R F L P
34
with 2 more sequence matches
10.7%
NZ_AXVJ01000055.1 and 3 others:
NZ_CP031030.1 Lanthipeptides: DTQ70_RS30930_lanthipeptide NZ_CP031030.1 Lanthipeptides: DTQ70_RS30935_lanthipeptide NZ_JACIBY010000001.1 Lanthipeptides: FHS57_RS00285_lanthipeptide
Lanthipeptides: K339_RS36965_lanthipeptide
32
N H P N T K H Y C E S
42
++P +K H Y C S
9
S N P T S K H Y C H S
19
7.1%
NZ_CP014326.1:
Lanthipeptides: AXK38_RS05515_lanthipeptide
38
H Y C E S V W E S T R E M
50
Y C ++W R +
40
Q Y C T A I W G I A R S L
52
allorf_0205278_0205448
Leader:
METAHLKIHFVKGLSNSFGK
Core:
N K N K N S T I K F V T A S I N N G C M W N T V F R N I Y R C L T P Y K
Core with dehydrations:
N K N K N Dha Dhb I K F V Dhb A Dha I N N G Cys M W N Dhb V F R N I Y R Cys L Dhb P Y K

#### antiSMASH-DB 4.0 matches for allorf_0205278_0205448

100.0%
NZ_CP015883.1 and 1 other:
NZ_JAASJP010000011.1 Lanthipeptides: allorf_43013_43183_lanthipeptide
Lanthipeptides: allorf_0205278_0205448_lanthipeptide
1
N K N K N S T I K F V T A S I N N G C M W N T V F R N I Y R C L T P Y K
36
N K N K N S T I K F V T A S I N N G C M W N T V F R N I Y R C L T P Y K
1
N K N K N S T I K F V T A S I N N G C M W N T V F R N I Y R C L T P Y K
36
52.8%
NZ_CP091901.1 and 5 others:
NZ_KB932317.1 Lanthipeptides: allorf_1274501_1274623_lanthipeptide NZ_KB944819.1 Lanthipeptides: allorf_0835577_0835699_lanthipeptide NZ_KB946767.1 Lanthipeptides: allorf_0873518_0873640_lanthipeptide NZ_KB946767.1 Lanthipeptides: allorf_0869748_0869870_lanthipeptide NZ_KZ845881.1 Lanthipeptides: allorf_0859524_0859646_lanthipeptide
Lanthipeptides: allorf_1827294_1827416_lanthipeptide
1
N K N K N S T I K F V T A S I N N G C M
20
N K N K N S I K F V T A S I N N G C M
1
N K N K N S M I K F V T A S I N N G C M
20
16.7%
NZ_BMSZ01000006.1:
Lanthipeptides: allorf_250966_251172_lanthipeptide
13
A S I N N G C M W N T V F R
26
A+ +G +W N+ F R
1
A A D G S G K V W N S T F R
14
with 2 more sequence matches
13.9%
NC_011071.1 and 41 others:
NZ_AP021867.1 Lassopeptides: GJU96_RS20605_lassopeptide NZ_CP011010.1 Lassopeptides: VN11_RS22530_lassopeptide NZ_CP011305.1 Lassopeptides: YH67_RS21020_lassopeptide NZ_CP015612.1 Lassopeptides: A7326_RS21600_lassopeptide NZ_CP027562.1 Lassopeptides: C6Y55_RS23185_lassopeptide NZ_CP029773.1 Lassopeptides: DM611_RS22725_lassopeptide NZ_CP031058.1 Lassopeptides: DUW70_RS11975_lassopeptide NZ_CP031167.1 Lassopeptides: MG068_RS21080_lassopeptide NZ_CP037858.1 Lassopeptides: EZ304_RS20935_lassopeptide NZ_CP040432.1 Lassopeptides: FEO95_RS22840_lassopeptide NZ_CP040438.1 Lassopeptides: FEO89_RS21625_lassopeptide NZ_CP040439.1 Lassopeptides: FEO88_RS23220_lassopeptide NZ_CP043578.1 Lassopeptides: F0Q13_RS11365_lassopeptide NZ_CP046588.1 Lassopeptides: GOC52_RS10870_lassopeptide NZ_CP047310.1 Lassopeptides: GS396_RS20180_lassopeptide NZ_CP060259.1 Lassopeptides: H7F32_RS11180_lassopeptide NZ_CP067993.1 Lassopeptides: JJL50_RS10815_lassopeptide NZ_CP077679.1 Lassopeptides: KS456_RS10490_lassopeptide NZ_CP080573.1 Lassopeptides: K1516_RS11235_lassopeptide NZ_CP090418.1 Lassopeptides: LYZ64_RS11980_lassopeptide NZ_CP096975.1 Lassopeptides: M1L61_RS12085_lassopeptide NZ_CP104169.1 Lassopeptides: NDR96_RS09175_lassopeptide NZ_CP106759.1 Lassopeptides: N8888_RS09665_lassopeptide NZ_CP120400.1 Lassopeptides: PVE91_RS09960_lassopeptide NZ_JABDRV010000002.1 Lassopeptides: HRL60_RS08285_lassopeptide NZ_JADCQA010000003.1 Lassopeptides: IMX13_RS03920_lassopeptide NZ_JAEDVS010000016.1 Lassopeptides: JAK50_RS09365_lassopeptide NZ_JAEDVW010000040.1 Lassopeptides: JAK53_RS10000_lassopeptide NZ_JAEDWA010000005.1 Lassopeptides: JAK63_RS01795_lassopeptide NZ_JAEDWK010000019.1 Lassopeptides: JAK51_RS11395_lassopeptide NZ_JAEDWU010000002.1 Lassopeptides: JAK37_RS06750_lassopeptide NZ_JAKJQX010000001.1 Lassopeptides: MT466_RS00850_lassopeptide NZ_JAQQGI010000001.1 Lassopeptides: PQS91_RS01155_lassopeptide NZ_JVHP01000037.1 Lassopeptides: ADI44_RS25485_lassopeptide NZ_JVPM01000019.1 Lassopeptides: ADH50_RS20965_lassopeptide NZ_JVUI01000038.1 Lassopeptides: ADG58_RS23065_lassopeptide NZ_OBEE01000001.1 Lassopeptides: CRO53_RS21815_lassopeptide NZ_OU943334.1 Lassopeptides: LNN95_RS11880_lassopeptide NZ_RHPZ01000001.1 Lassopeptides: EGJ03_RS21120_lassopeptide NZ_RHQE01000001.1 Lassopeptides: EGJ89_RS22430_lassopeptide NZ_SOCO01000001.1 Lassopeptides: N440_RS20340_lassopeptide
Lassopeptides: SMAL_RS21110_lassopeptide
16
N N G C M W N T V F
25
N+G +W+ V F
3
N H G T L W D G V F
12
13.9%
NZ_CP069611.1:
Lanthipeptides: allorf_33926_34045_lanthipeptide
27
N I Y R C L T P Y
35
++Y R C +P Y
5
S L Y R C F S P Y
13
allorf_0221021_0221083
Leader:
MRLMGIHEA
Core:
T I A Q Y T C I L C D
Core with dehydrations:
Dhb I A Q Y Dhb Cys I L Cys D

#### antiSMASH-DB 4.0 matches for allorf_0221021_0221083

100.0%
NZ_CP015883.1 and 1 other:
NZ_JAASJP010000011.1 Lanthipeptides: allorf_58686_58748_lanthipeptide
Lanthipeptides: allorf_0221021_0221083_lanthipeptide
1
T I A Q Y T C I L C D
11
T I A Q Y T C I L C D
1
T I A Q Y T C I L C D
11

#### MIBiG 4.0 matches for allorf_0221021_0221083

14.8%
BGC0002144.3 (RCCGEPOP_RS37510):
LAP: phazolicin
6
T C I L C D
11
T C C D
2
T C A R C D
7

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.29 out of 29.38
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 16.05 out of 18.16
Confidence: strong
Additional weak hits (3):
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.83 out of 26.85
Confidence: weak
DosR
Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 19.19 out of 29.51
Confidence: weak
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 15.62 out of 18.46
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

A6B47_RS00875 - Class II
  Cleavage pHMM score: 2.00
  RODEO score: 0
  Monoisotopic mass: 2630.3 Da
  Molecular weight: 2632.0 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2650.0 Da N = 1
    2668.0 Da N = 2
A6B47_RS00880 - Class II
  Cleavage pHMM score: 2.00
  RODEO score: 0
  Monoisotopic mass: 4017.0 Da
  Molecular weight: 4019.5 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4037.6 Da N = 1
    4055.6 Da N = 2
    4073.6 Da N = 3
    4091.6 Da N = 4
    4109.6 Da N = 5
A6B47_RS15575 - Class II
  Cleavage pHMM score: -5.80
  RODEO score: 0
  Monoisotopic mass: 5924.7 Da
  Molecular weight: 5928.4 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    5946.4 Da N = 1
    5964.4 Da N = 2
    5982.4 Da N = 3
    6000.5 Da N = 4
    6018.5 Da N = 5
    6036.5 Da N = 6
    6054.5 Da N = 7
allorf_0205278_0205448 - Class II
  Cleavage pHMM score: -6.90
  RODEO score: 0
  Monoisotopic mass: 4130.1 Da
  Molecular weight: 4132.8 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4150.8 Da N = 1
    4168.8 Da N = 2
    4186.8 Da N = 3
    4204.8 Da N = 4
allorf_0221021_0221083 - Class II
  Cleavage pHMM score: -6.00
  RODEO score: 0
  Monoisotopic mass: 1206.6 Da
  Molecular weight: 1207.4 Da
  Number of bridges: 2

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
FuR variant 1 | Ferric Uptake Regulator

NZ_CP015883.1 - Region 2 - NRPS,arylpolyene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 514,732 - 558,602 nt. (total: 43,871 nt) Show pHMM detection rules used
arylpolyene: (APE_KS1 or APE_KS2)
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
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Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase
A6B47_RS02720: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

A6B47_RS02775: aldo/keto reductase family oxidoreductase

smcogs
  SMCOG1039: aldo/keto reductase family oxidoreductase

Transferases: PPTase
A6B47_RS02675: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

Lyases: decarboxylase
A6B47_RS02795: Decarboxylase, pyridoxal-dependent

smcogs
  SMCOG1180: Decarboxylase, pyridoxal-dependent

Ligases: ligase synthase
A6B47_RS02745: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

A6B47_RS15745: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

Translocases: permease
A6B47_RS02800: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | arylpolyene | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | ---
BGC0001261.3 |  |  | 0.58 | NRPS | AM-toxin | Alternaria alternata
BGC0001166.5 |  |  | 0.57 | NRPS | HC-toxin | Alternaria jesenskae
BGC0002286.3 |  |  | 0.54 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002008.3 |  |  | 0.38 | other (other) | aryl polyenes | Xenorhabdus doucetiae
BGC0000836.5 |  |  | 0.37 | other (other) | APE Ec | Escherichia coli CFT073
BGC0000837.4 |  |  | 0.35 | other (other) | APE Vf | Aliivibrio fischeri ES114
BGC0000888.5 |  |  | 0.34 | other (other) | bacilysin | Bacillus sp. CS93
BGC0001928.2 |  |  | 0.33 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0002518.3 |  |  | 0.32 | NRPS | syringafactin A, syringafactin C | Pseudomonas sp. SZ57
BGC0002547.2 |  |  | 0.32 | PKS | youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4 | Streptomyces youssoufiensis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001261.3 |  | 0.62 | NRPS | AM-toxin | Alternaria alternata
BGC0001166.5 |  | 0.62 | NRPS | HC-toxin | Alternaria jesenskae
BGC0002286.3 |  | 0.61 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002008.3 |  | 0.51 | other (other) | aryl polyenes | Xenorhabdus doucetiae
BGC0000836.5 |  | 0.51 | other (other) | APE Ec | Escherichia coli CFT073
BGC0000837.4 |  | 0.49 | other (other) | APE Vf | Aliivibrio fischeri ES114
BGC0000888.5 |  | 0.49 | other (other) | bacilysin | Bacillus sp. CS93
BGC0001928.2 |  | 0.48 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0002518.3 |  | 0.47 | NRPS | syringafactin A, syringafactin C | Pseudomonas sp. SZ57
BGC0002547.2 |  | 0.47 | PKS | youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4 | Streptomyces youssoufiensis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.27 out of 26.06
Confidence: strong
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.55 out of 18.46
Confidence: strong
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.93 out of 30.25
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.54 out of 26.06
Confidence: medium
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 29.42 out of 32.74
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.37 out of 29.38
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.31 out of 30.25
Confidence: medium
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.99 out of 30.25
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.28 out of 27.78
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.48 out of 26.06
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 16.78 out of 18.16
Confidence: strong
Additional weak hits (2):
NrdR
Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 19.58 out of 27.18
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 23.73 out of 29.65
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 514731 - 558602:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (X)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
A6B47_RS02745: X
AMP-binding (15..416): X
nrpys: Gly, Ala, Val, Leu, Ile, Abu, Ival

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    LGMAFDPSIAQFDIISCGEFNFYGPSECSVYSTV
  Nearest Stachelhaus code(s):
    Cap DPQDIGIVNK (50% 8Å match)
  Stachelhaus code match:
    60% (weak)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator
FuR variant 1 | Ferric Uptake Regulator
FuR variant 2 | Ferric Uptake Regulator
MogR | Repressor of flagellar motility genes
RpoN | Regulator of nitrogen assimilation and virulence

NZ_CP015883.1 - Region 3 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 889,652 - 910,533 nt. (total: 20,882 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: peptidase
A6B47_RS04460: methionine aminopeptidase

smcogs
  SMCOG1172: methionine aminopeptidase

Ligases: synthetase
A6B47_RS04495: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002309.2 |  | 0.36 | terpene | cattleyene | Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000639.3 |  | 0.34 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.34 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0001605.3 |  | 0.32 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0001075.5 |  | 0.31 | PKS, terpene | aurachin RE | Rhodococcus erythropolis
BGC0001456.3 |  | 0.30 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000286.3 |  | 0.30 | PKS | viguiepinol | Streptomyces sp. KO-3988

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002309.2 |  | 0.36 | terpene | cattleyene | Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0000639.3 |  | 0.34 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.34 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0001605.3 |  | 0.32 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0001075.5 |  | 0.31 | PKS, terpene | aurachin RE | Rhodococcus erythropolis
BGC0001456.3 |  | 0.30 | terpene | isorenieratene | Streptomyces argillaceus
BGC0000286.3 |  | 0.30 | PKS | viguiepinol | Streptomyces sp. KO-3988

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
A6B47_RS04495: PT_FPPS_like
Domain 1 (29 - 276): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  DMAPP, IPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.25 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.38 out of 27.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.87 out of 28.19
Confidence: medium
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ZuR variant 1 | Zinc-responsive repressor

NZ_CP015883.1 - Region 4 - RRE-containing
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,250,765 - 1,271,898 nt. (total: 21,134 nt) Show pHMM detection rules used
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: reductase
A6B47_RS06405: alkyl hydroperoxide reductase subunit

smcogs
  SMCOG1176: alkyl hydroperoxide reductase subunit

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RRE-containing | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000585.5 |  | 0.44 | ribosomal | microcin C7 | Escherichia coli
BGC0000626.3 |  | 0.40 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000528.5 |  | 0.40 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001743.3 |  | 0.40 | ribosomal | plantaricyclin | Lactobacillus plantarum
BGC0001660.3 |  | 0.40 | ribosomal | mathermycin | Marinactinospora thermotolerans
BGC0001210.5 |  | 0.40 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000616.4 |  | 0.39 | ribosomal | amylocyclicin | Bacillus velezensis FZB42
BGC0000527.5 |  | 0.39 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0001787.3 |  | 0.39 | ribosomal | suicin 3908 | Streptococcus suis
BGC0000521.3 |  | 0.38 | ribosomal | lacticin 481 | Lactococcus lactis subsp. lactis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000585.5 |  | 0.44 | ribosomal | microcin C7 | Escherichia coli
BGC0000626.3 |  | 0.40 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000528.5 |  | 0.40 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001743.3 |  | 0.40 | ribosomal | plantaricyclin | Lactobacillus plantarum
BGC0001660.3 |  | 0.40 | ribosomal | mathermycin | Marinactinospora thermotolerans
BGC0001210.5 |  | 0.40 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000616.4 |  | 0.39 | ribosomal | amylocyclicin | Bacillus velezensis FZB42
BGC0000527.5 |  | 0.39 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0001787.3 |  | 0.39 | ribosomal | suicin 3908 | Streptococcus suis
BGC0000521.3 |  | 0.38 | ribosomal | lacticin 481 | Lactococcus lactis subsp. lactis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 25.18 out of 26.06
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.86 out of 26.06
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.52 out of 26.06
Confidence: medium
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 26.12 out of 26.12
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.70 out of 20.97
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.98 out of 27.78
Confidence: medium
Additional weak hits (4):
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.13 out of 26.85
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.90 out of 31.73
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 24.16 out of 35.63
Confidence: weak
HypR
Description: L-hydroxyproline utilization repressor
Species: Streptomyces coelicolor
Score: 18.79 out of 22.40
Confidence: weak
RREFinder
TFBS Finder
RRE predictions
RREfinder results sidepanel.

RRE-containing protocluster (1250764...1271898)
A6B47_RS06360
  RRE type: Pantocin_Microcin_RRE
  Location: 5 - 89
  Score: 38.0

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
LuxO | Repressor of luminescence
MogR | Repressor of flagellar motility genes

NZ_CP015883.1 - Region 5 - cyclic-lactone-autoinducer
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,674,786 - 1,695,514 nt. (total: 20,729 nt) Show pHMM detection rules used
cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | cyclic-lactone-autoinducer | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001291.3 |  | 0.41 | ribosomal | enterocin NKR-5-3B | Enterococcus faecium
BGC0001948.3 |  | 0.37 | other (other) | naseseazine C, C3-aryl pyrroloindolines | Streptomyces sp.
BGC0000046.4 |  | 0.35 | PKS | depudecin | Alternaria brassicicola
BGC0002227.3 |  | 0.31 | NRPS | AKML B, AKML D, AKML A, AKML C | Aspergillus luchuensis IFO 4308
BGC0002667.2 |  | 0.30 | ribosomal | estericin A | Clostridium estertheticum
BGC0000688.4 |  | 0.29 | terpene | copalyl diphosphate | Diaporthe amygdali
BGC0001954.2 |  | 0.28 | NRPS, PKS | wortmanamide A, wortmanamide B | Talaromyces wortmannii
BGC0001366.5 |  | 0.27 | PKS | BE-24566B, zunyimycin A | Streptomyces sp. FJS31-2
BGC0002058.3 |  | 0.27 | NRPS, PKS | mutanocyclin | Streptococcus mutans B04Sm5
BGC0002287.2 |  | 0.27 | NRPS | mutanocyclin, leuvalin, tyrvalin | Streptococcus mutans

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001291.3 |  | 0.41 | ribosomal | enterocin NKR-5-3B | Enterococcus faecium
BGC0001948.3 |  | 0.37 | other (other) | naseseazine C, C3-aryl pyrroloindolines | Streptomyces sp.
BGC0000046.4 |  | 0.35 | PKS | depudecin | Alternaria brassicicola
BGC0002227.3 |  | 0.31 | NRPS | AKML B, AKML D, AKML A, AKML C | Aspergillus luchuensis IFO 4308
BGC0002667.2 |  | 0.30 | ribosomal | estericin A | Clostridium estertheticum
BGC0000688.4 |  | 0.29 | terpene | copalyl diphosphate | Diaporthe amygdali
BGC0001954.2 |  | 0.28 | NRPS, PKS | wortmanamide A, wortmanamide B | Talaromyces wortmannii
BGC0001366.5 |  | 0.27 | PKS | BE-24566B, zunyimycin A | Streptomyces sp. FJS31-2
BGC0002058.3 |  | 0.27 | NRPS, PKS | mutanocyclin | Streptococcus mutans B04Sm5
BGC0002287.2 |  | 0.27 | NRPS | mutanocyclin, leuvalin, tyrvalin | Streptococcus mutans

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 28.99 out of 30.25
Confidence: strong
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.08 out of 23.79
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.55 out of 19.26
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.50 out of 23.79
Confidence: medium
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
ColR | Phenol-responsive regulator
IolR | Regulator of the inositol catabolism

NZ_CP015884.1 - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 114,557 - 124,703 nt. (total: 10,147 nt) Show pHMM detection rules used
Region on contig edge.
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000618.3 |  | 0.56 | ribosomal | enterocin A | Enterococcus faecium DO

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000618.3 |  | 0.56 | ribosomal | enterocin A | Enterococcus faecium DO

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 15.06 out of 18.16
Confidence: strong
Additional weak hits (2):
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 20.68 out of 26.12
Confidence: weak
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.10 out of 25.88
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator

NZ_CP015885.1 - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 37,487 - 49,637 nt. (total: 12,151 nt) Show pHMM detection rules used
Region on contig edge.
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002579.2 |  | 0.51 | ribosomal | carnobacteriocin XY | Carnobacterium maltaromaticum
BGC0002577.2 |  | 0.48 | ribosomal | lactococcin G | Lactococcus lactis
BGC0000617.5 |  | 0.44 | ribosomal | coagulin | Bacillus coagulans
BGC0000558.5 |  | 0.43 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0001862.4 |  | 0.41 | ribosomal | pallidocin | Aeribacillus pallidus
BGC0002674.2 |  | 0.40 | ribosomal | enterocin F4-9 | Enterococcus faecalis
BGC0000484.5 |  | 0.39 | ribosomal | glycocin F | Lactobacillus plantarum
BGC0001863.4 |  | 0.39 | ribosomal, terpene | bacillicn CER074 | Bacillus mycoides
BGC0001388.3 |  | 0.38 | ribosomal | gassericin E | Lactobacillus gasseri
BGC0000619.3 |  | 0.38 | ribosomal | gassericin T | Lactobacillus gasseri

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002579.2 |  | 0.51 | ribosomal | carnobacteriocin XY | Carnobacterium maltaromaticum
BGC0002577.2 |  | 0.48 | ribosomal | lactococcin G | Lactococcus lactis
BGC0000617.5 |  | 0.44 | ribosomal | coagulin | Bacillus coagulans
BGC0000558.5 |  | 0.43 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0001862.4 |  | 0.41 | ribosomal | pallidocin | Aeribacillus pallidus
BGC0002674.2 |  | 0.40 | ribosomal | enterocin F4-9 | Enterococcus faecalis
BGC0000484.5 |  | 0.39 | ribosomal | glycocin F | Lactobacillus plantarum
BGC0001863.4 |  | 0.39 | ribosomal, terpene | bacillicn CER074 | Bacillus mycoides
BGC0001388.3 |  | 0.38 | ribosomal | gassericin E | Lactobacillus gasseri
BGC0000619.3 |  | 0.38 | ribosomal | gassericin T | Lactobacillus gasseri

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.38 out of 25.88
Confidence: medium
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.01 out of 32.93
Confidence: medium
Additional weak hits (1):
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.01 out of 26.85
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
LexA variant 3 | Repressor of DNA damage response
PsrA | Oleic acid responsive regulator